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English Abstract
A vaccine for the immunocontraception of mammals is described. The vaccine consists of zona pellucida antigens and an
adjuvant encapsulated in a liposome delivery system. The liposome delivery system allows for the slow release of antigen resulting
in a prolonged immune response. In particular, after a single injection of the vaccine, levels of anti-zona pellucida antibodies
were detected for up to 22 months. Thus, the vaccine according to the present invention is effective after a single dose and is
therefore very useful in immunocontraceptive protocols.
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