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Patent Summary
| (12) Patent: | (11) CA 2210924 |
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| (54) English Title: | PACLITAXEL ANALOGS, PREPARATION AND USE AS ANTITUMOR AGENTS |
| (54) French Title: | ANALOGUES DU PACLITAXEL, LEUR PREPARATION ET LEUR UTILISATION EN TANT QU'AGENTS CONTRE LES TUMEURS |
Abstract
The present invention provides novel paclitaxel
analogs, specifically 2", 3" side-chain halogenated
cephalomannine of the formula
Image
wherein,
I. (2"R,3"S)-dihalocephalomannine
Image
II. (2"S,3"R)-dihalocephalomannine
Image
III. (2"R,3"S)-dihalo-7-epi-cephalomannine
Image
IV. (2"S,3"R)-dihalo-7-epi-cephalomannine
Image
(2"y 3"S)-dihalocephalomannine
Image R1=H R2=OH
(2" R~3"R)-dihalocepha~omannine
R ' Image Rt=OH Ri=H
(2"'S~3"S)-dihalo-7-epi-cephalomannine
Rl-H RZnOH
Image
(2"R,3"R)-dihalo-7-epi-cephalomannine
R _ R~=H Ri=OH
Image
and X = halogen, which show strong in vitro and in vivo
paclitaxel-like efficacy in a variety of tumors.
Note: Data on abstracts and claims is shown in the official language in which it was submitted.
Patent Details
| (51) International Patent Classification (IPC): |
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| (72) Inventors (Country): |
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| (73) Owners (Country): |
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| (71) Applicants (Country): |
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| (74) Agent: | BERESKIN & PARR |
| (45) Issued: | 2004-03-02 |
| (86) PCT Filing Date: | 1996-12-13 |
| (87) PCT Publication Date: | 1997-08-14 |
| Examination requested: | 1999-12-22 |
| (30) Availability of licence: | N/A |
| (30) Language of filing: | English |
| Patent Cooperation Treaty (PCT): | Yes |
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| (86) PCT Filing Number: | PCT/US1996/019676 |
| (87) International Publication Number: | WO1997/029098 |
| (85) National Entry: | 1997-07-21 |
| (30) Application Priority Data: | |||||||||||||
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| View Patent Image | Download Patent Image in PDF Format | Size of Image (KB) | Number of Pages |
|---|---|---|---|
| Cover Page | Cover Page | 42 | 1 |
| Abstract | Abstract | 30 | 3 |
| Claims | Claims | 324 | 16 |
| Description | Description | 2,577 | 89 |
| Drawings | Drawings | 686 | 46 |
| Representative Drawing | Representative Drawing | 6 | 1 |
