Canadian Patents Database / Patent 2355168 Summary

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(12) Patent Application: (11) CA 2355168
(54) English Title: EGG ANTI-INFLAMMATORY COMPOSITION AND METHOD OF TREATING AND PREVENTING INFLAMMATION
(54) French Title: COMPOSITION ANTI-INFLAMMATOIRE A BASE D'OEUF ET METHODE DE TRAITEMENT ET DE PREVENTION DE L'INFLAMMATION
(51) International Patent Classification (IPC):
  • A61K 35/54 (2006.01)
  • A61P 29/00 (2006.01)
(72) Inventors (Country):
  • FITZPATRICK-MCELLIGOTT, SANDRA (United States of America)
  • LEE, YOUNG-ZOON (United States of America)
  • BECK, LEE R. (United States of America)
  • ADALSTEINSSON, ORN (United States of America)
  • DALEY, MICHAEL J. (United States of America)
  • XING, RUYE (United States of America)
  • IYER, SUBRAMANIAN (United States of America)
  • HUNCHAR, JEFFREY G. (United States of America)
  • GREENBLATT, HELLEN CHAYA (United States of America)
(73) Owners (Country):
  • ARKION LIFE SCIENCES (United States of America)
(71) Applicants (Country):
  • DCV, INC. (United States of America)
(74) Agent: DIMOCK STRATTON LLP
(45) Issued:
(86) PCT Filing Date: 1999-12-28
(87) PCT Publication Date: 2000-07-27
(30) Availability of licence: N/A
(30) Language of filing: English

(30) Application Priority Data:
Application No. Country Date
09/233,379 United States of America 1999-01-19

English Abstract




The invention is directed to a composition and method for the treatment and
prevention of inflammation in general. The composition is an egg product
obtained from an avian which has been hyperimmunized with no immunogenic
mixture. The invention is further directed to an anti-inflammatory composition
which has been partially purified from a hyperimmunized egg. The partially
purified anti-inflammatory composition, when administered to a subject animal
is effective in treating and preventing inflammation.


French Abstract

L'invention concerne une composition et une méthode de traitement et de prévention de l'inflammation en général. Ladite composition est un produit de l'oeuf, provenant d'un oiseau ayant été hyperimmunisé à l'aide d'un mélange immunogène. L'invention porte également sur une composition anti-inflammatoire ayant été partiellement purifiée, provenant d'un oeuf immunisé. La composition anti-inflammatoire partiellement purifiée, lorsqu'elle est administrée à un sujet animal, est efficace dans le traitement et la prévention de l'inflammation.


Note: Claims are shown in the official language in which they were submitted.




CLAIMS


WE CLAIM

1. An anti-inflammatory composition in partially purified form, wherein said
anti-inflammatory composition comprises the following characteristics:
a) being present in whole egg, egg white and egg yolk of an egg produced by
an egg-producing animal;
b) having a molecular weight of less than approximately 3000 daltons;
c) being heat stable;
d) being orally active; and
e) being resistant to degradation by digestive enzymes.
2. The anti-inflammatory composition of claim 1 wherein the egg-producing
animal has been hyperimmunized with an immunogenic or genetic vaccine.
3. The anti-inflammatory composition of claim 2 wherein the immunogenic
vaccine comprises at least one antigen selected from the group consisting of
bacterial, viral, protozoan, fungal and cellular immunogens and mixtures
thereof.
4. The anti-inflammatory composition of claim 2 wherein the genetic vaccine
comprises at least one immunogen coding DNA construct selected from the
group consisting of fragments of naked DNA, plasmid DNA, viral DNA,
bacterial DNA, DNA expression libraries, DNA-RNA immunogens, DNA-
protein conjugates and DNA liposome conjugates, and mixtures thereof.



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5. The anti-inflammatory composition of claim 1 wherein the ante-inflammatory
composition is partially purified by the method comprising:
a) defatting the whole egg, egg yolk or egg white;
b) isolating a water soluble fraction from the de-fatted whole egg, egg yolk
or
egg white;
c) separating a less than approximately 3000 dalton permeate from the water
soluble fraction; and
d) fractionating said less than approximately 3000 dalton permeate to recover
said partially purified anti-inflammatory composition.
6. A method for treating and preventing inflammation in a subject animal
suffering from or susceptable to inflammation, the method comprising
administering to the subject animal an effective amount of an egg product.
7. The method of claim 6 wherein the egg product is selected from the group
consisting of whole egg, egg yolk, egg white and any fraction thereof.
8. The method of claim 7 wherein the egg product is obtained from an egg-
producing animal which has been hyperimmunized with an immunogenic or
genetic vaccine.
9. The method of claim 8 wherein the immunogenic vaccine comprises at least
one antigen selected from the group consisting of bacterial, viral, protozoan,
fungal and cellular immunogens and mixtures thereof.
10. The method of claim 8 wherein the genetic vaccine comprises at least one
immunogen coding DNA construct selected from the group consisting of
fragments of naked DNA, plasmid DNA, viral DNA, bacterial DNA, DNA
expression libraries, DNA-RNA immunogens, DNA-protein conjugates and
DNA liposome conjugates, and mixtures thereof.
11. The method of claim 7 wherein the egg product further comprises an anti-
inflammatory composition.



51




12. The method of claim 11 wherein the anti-inflammatory composition is
partially purified and comprises the following characteristics:
a) being present in whole egg, egg white and egg yolk of an egg produced by
an egg-producing animal;
b) having a molecular weight of less than approximately 3000 daltons;
c) being heat stable;
d) being orally active; and
e) being resistant to degradation by digestive enzymes.
13. The method of claim 12 wherein the anti-inflammatory composition is
partially purified by the method comprising:
e) defatting the whole egg, egg yolk or egg white;
f) isolating a water soluble fraction from the de-fatted whole egg, egg yolk
or
egg white;
g) separating a less than approximately 3000 dalton permeate from the water
soluble fraction; and
h) fractionating said less than approximately 3000 dalton permeate to recover
said partially purified anti-inflammatory composition.
14. The method of claim 6 wherein the inflammation comprises arthritis.
15. The method of claim 7 wherein the effective amount of egg product
administered is between approximately 100 milligrams and 10 grams of whole
egg per kilogram of subject weight, or the equivalent thereof for a fraction
of
the whole egg.
16. The method of claim 12 wherein the effective amount of partially purified
anti-inflammatory composition administered is between approximately 1
microgram and 400 milligrams per kilogram of subject weight.



52



17. A method of treating an autoimmune disease in a subject animal suffering
from or susceptable to said autoimmune disease, the method comprising
administering to the subject animal an effective amount of an egg product.
18. The method of claim 17 wherein the egg product is obtained from an egg-
producing animal which has been hyperimmunized with an immunogenic or
genetic vaccine.
19. The method of claim 18 wherein the egg product further comprises an anti-
inflammatory composition.
20. The method of claim 19 wherein the anti-inflammatory composition is
partially purified and comprises the following characteristics:
a) being present in whole egg, egg white and egg yolk of an egg produced by
an egg-producing animal;
b) having a molecular weight of less than approximately 3000 daltons;
c) being heat stable;
d) being orally active; and
e) being resistant to degradation by digestive enzymes.



53


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Admin Status

Title Date
(86) PCT Filing Date 1999-12-28
(87) PCT Publication Date 2000-07-27
(85) National Entry 2001-06-13
Dead Application 2005-12-28

Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Filing $300.00 2001-06-13
Maintenance Fee - Application - New Act 2 2001-12-28 $100.00 2001-06-13
Registration of Documents $100.00 2002-02-20
Registration of Documents $50.00 2002-07-12
Maintenance Fee - Application - New Act 3 2002-12-30 $100.00 2002-09-27
Maintenance Fee - Application - New Act 4 2003-12-29 $100.00 2003-09-23
Maintenance Fee - Application - New Act 5 2004-12-28 $200.00 2004-10-05
Maintenance Fee - Application - New Act 6 2005-12-28 $200.00 2005-12-28

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Document
Description
Date
(yyyy-mm-dd)
Number of pages Size of Image (KB)
Cover Page 2001-10-11 2 37
Abstract 2001-06-13 1 59
Description 2001-06-13 49 2,336
Claims 2001-06-13 4 136
Drawings 2001-06-13 6 111
Correspondence 2001-09-05 1 25
PCT 2001-06-13 13 445
Fees 2003-09-23 1 37
Fees 2002-09-27 1 39
Fees 2004-10-05 1 35
Fees 2005-12-28 1 37