Canadian Patents Database / Patent 2378478 Summary

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(12) Patent Application: (11) CA 2378478
(54) English Title: FERTILITY IMPAIRING VACCINE CONTAINING AVIAN ZONA PELLUCIDA PROTEIN AND METHOD OF USE
(54) French Title: VACCIN ANTI-FECONDITE CONTENANT UNE PROTEINE DE MEMBRANE PELLUCIDE AVIAIRE ET PROCEDE D'UTILISATION
(51) International Patent Classification (IPC):
  • A61K 38/17 (2006.01)
  • A61P 15/18 (2006.01)
(72) Inventors (Country):
  • FAYRER-HOSKEN, RICHARD (United States of America)
  • RITCHIE, BRANSON W. (United States of America)
(73) Owners (Country):
  • THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (United States of America)
(71) Applicants (Country):
  • THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (United States of America)
(74) Agent: SMART & BIGGAR
(45) Issued:
(86) PCT Filing Date: 2000-06-30
(87) PCT Publication Date: 2001-01-11
Examination requested: 2005-06-21
(30) Availability of licence: N/A
(30) Language of filing: English

(30) Application Priority Data:
Application No. Country Date
60/141,929 United States of America 1999-07-01
60/162,984 United States of America 1999-11-02

English Abstract




A vaccine comprising an immunogen derived from an avian zona pellucida protein
is useful for immunocontraception and immunosterilization of animals.


French Abstract

L'invention se rapporte à un vaccin comportant un immunogène dérivé d'une protéine de membrane pellucide aviaire. Ce vaccin s'avère utile pour l'immunocontraception et l'immunostérilisation d'animaux.


Note: Claims are shown in the official language in which they were submitted.


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WHAT IS CLAIMED IS:

1. A fertility impairing vaccine comprising at least one component selected
from the group consisting of (a) a polypeptide comprising an avian zona
pellucida protein or an immunogenic fragment thereof and (b) a polynucleotide
comprising a nucleotide sequence encoding a polypeptide comprising an avian
zona pellucida protein or an immunogenic fragment thereof.
2. The fertility impairing vaccine of claim 1 wherein the avian zona pellucida
protein is a glycoprotein.
3. The fertility impairing vaccine of claim 1 wherein the avian zona pellucida
protein is a naturally occurring protein.
4. The fertility impairing vaccine of claim 1 wherein the avian zona pellucida
protein is a recombinant protein.
5. The fertility impairing vaccine of claim 1 wherein the avian zona pellucida
protein is a chemically or enzymatically synthesized protein.
6. The fertility impairing vaccine of claim 1 further comprising an
immunological adjuvant.
7. The fertility impairing vaccine of claim 6 wherein the immunological
adjuvant comprises synthetic trehalose dicorynomycolate.
8. The fertility impairing vaccine of claim 1 further comprising squalene oil.
9. The fertility impairing vaccine of claim 1 wherein the polypeptide further
comprises at least one epitope selected from the group consisting of a T cell
epitope, a helper T cell epitope and a B cell epitope.


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10. The fertility impairing vaccine of claim 1 which is an immunosterilant
vaccine.
11. The fertility impairing vaccine of claim 1 which is an immunocontraceptive
vaccine.
12. The fertility impairing vaccine of claim 1 wherein the polynucleotide
comprises a vector.
13. The fertility impairing vaccine of claim 12 wherein the vector is a
plasmid.
14. The fertility impairing vaccine of claim 12 wherein the vector is a viral
vector.
15. The fertility impairing vaccine of claim 1 wherein the polynucleotide
further comprises a regulatory sequence operably linked to the nucleotide
sequence encoding the polypeptide comprising the avian zona pellucida protein
or immunogenic fragment thereof.
16. The fertility impairing vaccine of claim 1 wherein the polynucleotide
further
comprises an immunostimulatory sequence.
17. A method for impairing the fertility of an animal comprising administering
to the animal a fertility impairing vaccine of any of the preceding claims
wherein the vaccine is administered in a manner and an amount effective to
cause fertility impairment in the animal.
18. The method of claim 17 wherein the vaccine causes temporary, reversible
infertility in the animal.
19. The method of claim 17 wherein the vaccine causes permanent, irreversible
infertility in the animal.


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20. The method of claim 17 wherein the animal is a mammal.
21. The method of claim 20 wherein the mammal is selected from the group
consisting a horse, a deer, an elephant, a rat, a mouse, a rabbit, a ferret, a
dog
and a cat.
22. The method of claim 21 wherein the animal is a dog.
23. The method of claim 21 wherein the animal is a cat.
24. The method of claim 17 wherein the animal is a bird.
25. The method of claims 17-24 wherein the fertility impairing vaccine further
comprises at least one component selected from the group consisting of (a) a
polypeptide comprising a porcine zona pellucida protein or an immunogenic
fragment thereof and (b) a polynucleotide comprising a nucleotide sequence
encoding a polypeptide comprising a porcine zona pellucida protein or an
immunogenic fragment thereof.
26. The method of claim 25 wherein the fertility impairing vaccine is a
polypeptide vaccine, and wherein the ratio (aZP:pZP) of avian zona pellucida
protein (aZP) to porcine zona pellucida protein (pZP) is about 100:1 to about
1:100.
27. The fertility impairing vaccine of claims 1-16 further comprising at least
one component selected from the group consisting of (a) a polypeptide
comprising a porcine zona pellucida protein or an immunogenic fragment
thereof and (b) a polynucleotide comprising a nucleotide sequence encoding a
polypeptide comprising a porcine zona pellucida protein or an immunogenic
fragment thereof.


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28. The fertility impairing vaccine of claim 27 which is a polypeptide vaccine
wherein the ratio (aZP:pZP) of avian zona pellucida protein (aZP) to porcine
zona pellucida protein (pZP) is about 100:1 to about 1:100.


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Admin Status

Title Date
(86) PCT Filing Date 2000-06-30
(87) PCT Publication Date 2001-01-11
(85) National Entry 2001-12-28
Examination Requested 2005-06-21
Dead Application 2007-07-03

Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Registration of Documents $100.00 2001-12-28
Filing $300.00 2001-12-28
Maintenance Fee - Application - New Act 2 2002-07-02 $100.00 2002-06-28
Maintenance Fee - Application - New Act 3 2003-06-30 $100.00 2003-06-25
Maintenance Fee - Application - New Act 4 2004-06-30 $100.00 2004-06-18
Maintenance Fee - Application - New Act 5 2005-06-30 $200.00 2005-06-20
Request for Examination $800.00 2005-06-21

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Description
Date
(yyyy-mm-dd)
Number of pages Size of Image (KB)
Abstract 2001-12-28 1 49
Claims 2001-12-28 4 104
Description 2001-12-28 18 911
Cover Page 2002-06-26 1 27
PCT 2001-12-28 12 454
Prosecution-Amendment 2001-12-28 1 18
Prosecution-Amendment 2005-06-21 1 38