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Patent Summary

(12) Patent Application: (11) CA 2395693
(54) English Title: NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES
(54) French Title: ACIDES NUCLEIQUES, PROTEINES ET ANTICORPS

Abstracts

English Abstract




The present invention relates to novel excretory system related
polynucleotides and the polypeptides encoded by these polynucleotides herein
collectively known as "excretory system antigens", and the use of such
excretory system antigens for detecting disorders of the excretory system,
particularly the presence of cancer of excretory system tissues and cancer
metastases. More specifically, isolated excretory system associated nucleic
acid molecules are provided encoding novel excretory system associated
polypeptides. Novel excretory system polypeptides and antibodies that bind to
these polypeptides are provided. Also provided are vectors, host cells, and
recombinant and synthetic methods for producing human excretory system
associated polynucleotides and/or polypeptides. The invention further relates
to diagnostic and therapeutic methods useful for diagnosing, treating,
preventing and/or prognosing disorders related to the excretory system,
including cancer of excretory system tissues, and therapeutic methods for
treating such disorders. The invention further relates to screening methods
for identifying agonists and antagonists of polynucleotides and polypeptides
of the invention. The present invention further relates to methods and/or
compositions for inhibiting the production and function of the polypeptides of
the present invention.


French Abstract

La présente invention se rapporte à de nouveaux polynucléotides associés au système excrétoire et aux polypeptides codés par ces polynucléotides, désignés ci-après collectivement sous le nom "d'antigènes du système excrétoire", et à l'utilisation de ces antigènes du système excrétoire pour détecter des troubles du système excrétoire, et notamment la présence d'un cancer des tissus et de métastases cancéreuses. Plus spécifiquement, l'invention se rapporte à des molécules d'acides nucléiques isolées, associées au système excrétoire, qui codent de nouveaux polypeptides associés au système excrétoire. Elle se rapporte à de nouveaux polypeptides du système excrétoire et à des anticorps qui se lient à ces polypeptides. Elle se rapporte également à des vecteurs, à des cellules hôtes et à des procédés de synthèse et de recombinaison pour la production de polynucléotides et/ou de polypeptides associés au système excrétoire humain. Cette invention se rapporte également à des méthodes diagnostiques et thérapeutiques permettant de diagnostiquer, traiter, prévenir et/ou pronostiquer des troubles liés au système excrétoire, et notamment un cancer des tissus du système excrétoire, ainsi qu'à des méthodes thérapeutiques permettant de traiter de tels troubles. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes des polynucléotides et des polypeptides décrits ci-dessus. Elle se rapporte enfin à des procédés et/ou à des compositions permettant d'inhiber la production et la fonction desdits polypeptides.



Patent Details

(51) International Patent Classification (IPC):
  • C12N 15/00 (2006.01)
  • C07K 1/00 (2006.01)
  • C07K 14/47 (2006.01)
  • C07K 14/705 (2006.01)
  • C07K 16/18 (2006.01)
  • C12N 9/00 (2006.01)
  • C12N 9/64 (2006.01)
  • C12Q 1/68 (2006.01)
  • A61K 38/00 (2006.01)
  • A61K 48/00 (2006.01)
(72) Inventors (Country):
  • ROSEN, CRAIG A. (United States of America)
  • BARASH, STEVEN C. (United States of America)
  • RUBEN, STEVEN M. (United States of America)
(73) Owners (Country):
  • ROSEN, CRAIG A. (Not Available)
  • BARASH, STEVEN C. (Not Available)
  • RUBEN, STEVEN M. (Not Available)
(71) Applicants (Country):
  • HUMAN GENOME SCIENCES, INC. (United States of America)
(74) Agent: MBM & CO.
(45) Issued:
(86) PCT Filing Date: 2001-01-17
(87) PCT Publication Date: 2001-08-02
(30) Availability of licence: N/A
(30) Language of filing: English

(30) Application Priority Data:
Application No. Country Date
60/179,065 United States of America 2000-01-31
60/214,886 United States of America 2000-06-28
60/246,613 United States of America 2000-11-08
60/246,609 United States of America 2000-11-08
60/246,478 United States of America 2000-11-08
60/246,524 United States of America 2000-11-08
60/246,523 United States of America 2000-11-08
60/249,299 United States of America 2000-11-17
60/249,210 United States of America 2000-11-17
60/249,216 United States of America 2000-11-17
60/249,217 United States of America 2000-11-17
60/249,211 United States of America 2000-11-17
60/215,135 United States of America 2000-06-30
60/249,215 United States of America 2000-11-17
60/249,218 United States of America 2000-11-17
60/249,208 United States of America 2000-11-17
60/249,213 United States of America 2000-11-17
60/249,212 United States of America 2000-11-17
60/249,207 United States of America 2000-11-17
60/249,245 United States of America 2000-11-17
60/249,244 United States of America 2000-11-17
60/249,297 United States of America 2000-11-17
60/249,214 United States of America 2000-11-17
60/216,647 United States of America 2000-07-07
60/249,264 United States of America 2000-11-17
60/249,209 United States of America 2000-11-17
60/249,300 United States of America 2000-11-17
60/249,265 United States of America 2000-11-17
60/250,391 United States of America 2000-12-01
60/250,160 United States of America 2000-12-01
60/256,719 United States of America 2000-12-05
60/251,030 United States of America 2000-12-05
60/251,988 United States of America 2000-12-05
60/251,479 United States of America 2000-12-06
60/216,880 United States of America 2000-07-07
60/251,869 United States of America 2000-12-08
60/251,856 United States of America 2000-12-08
60/251,868 United States of America 2000-12-08
60/251,990 United States of America 2000-12-08
60/251,989 United States of America 2000-12-08
60/254,097 United States of America 2000-12-11
60/259,678 United States of America 2001-01-05
60/217,487 United States of America 2000-07-11
60/217,496 United States of America 2000-07-11
60/218,290 United States of America 2000-07-14
60/220,963 United States of America 2000-07-26
60/220,964 United States of America 2000-07-26
60/225,757 United States of America 2000-08-14
60/180,628 United States of America 2000-02-04
60/225,270 United States of America 2000-08-14
60/225,447 United States of America 2000-08-14
60/225,267 United States of America 2000-08-14
60/225,758 United States of America 2000-08-14
60/225,268 United States of America 2000-08-14
60/224,518 United States of America 2000-08-14
60/224,519 United States of America 2000-08-14
60/225,759 United States of America 2000-08-14
60/225,213 United States of America 2000-08-14
60/225,266 United States of America 2000-08-14
60/184,664 United States of America 2000-02-24
60/225,214 United States of America 2000-08-14
60/226,279 United States of America 2000-08-18
60/226,868 United States of America 2000-08-22
60/227,182 United States of America 2000-08-22
60/226,681 United States of America 2000-08-22
60/227,009 United States of America 2000-08-23
60/228,924 United States of America 2000-08-30
60/229,344 United States of America 2000-09-01
60/229,343 United States of America 2000-09-01
60/229,287 United States of America 2000-09-01
60/186,350 United States of America 2000-03-02
60/229,345 United States of America 2000-09-01
60/229,513 United States of America 2000-09-05
60/229,509 United States of America 2000-09-05
60/230,438 United States of America 2000-09-06
60/230,437 United States of America 2000-09-06
60/231,413 United States of America 2000-09-08
60/232,080 United States of America 2000-09-08
60/231,414 United States of America 2000-09-08
60/231,244 United States of America 2000-09-08
60/232,081 United States of America 2000-09-08
60/189,874 United States of America 2000-03-16
60/231,242 United States of America 2000-09-08
60/231,243 United States of America 2000-09-08
60/231,968 United States of America 2000-09-12
60/232,401 United States of America 2000-09-14
60/232,399 United States of America 2000-09-14
60/232,400 United States of America 2000-09-14
60/232,397 United States of America 2000-09-14
60/233,063 United States of America 2000-09-14
60/233,064 United States of America 2000-09-14
60/233,065 United States of America 2000-09-14
60/190,076 United States of America 2000-03-17
60/232,398 United States of America 2000-09-14
60/234,223 United States of America 2000-09-21
60/234,274 United States of America 2000-09-21
60/234,997 United States of America 2000-09-25
60/234,998 United States of America 2000-09-25
60/235,484 United States of America 2000-09-26
60/235,834 United States of America 2000-09-27
60/235,836 United States of America 2000-09-27
60/236,369 United States of America 2000-09-29
60/236,327 United States of America 2000-09-29
60/198,123 United States of America 2000-04-18
60/236,370 United States of America 2000-09-29
60/236,368 United States of America 2000-09-29
60/236,367 United States of America 2000-09-29
60/237,039 United States of America 2000-10-02
60/237,038 United States of America 2000-10-02
60/237,040 United States of America 2000-10-02
60/237,037 United States of America 2000-10-02
60/236,802 United States of America 2000-10-02
60/239,937 United States of America 2000-10-13
60/239,935 United States of America 2000-10-13
60/205,515 United States of America 2000-05-19
60/241,785 United States of America 2000-10-20
60/241,809 United States of America 2000-10-20
60/240,960 United States of America 2000-10-20
60/241,787 United States of America 2000-10-20
60/241,808 United States of America 2000-10-20
60/241,221 United States of America 2000-10-20
60/241,786 United States of America 2000-10-20
60/241,826 United States of America 2000-10-20
60/244,617 United States of America 2000-11-01
60/246,474 United States of America 2000-11-08
60/209,467 United States of America 2000-06-07
60/246,532 United States of America 2000-11-08
60/246,476 United States of America 2000-11-08
60/246,526 United States of America 2000-11-08
60/246,475 United States of America 2000-11-08
60/246,525 United States of America 2000-11-08
60/246,528 United States of America 2000-11-08
60/246,527 United States of America 2000-11-08
60/246,477 United States of America 2000-11-08
60/246,611 United States of America 2000-11-08
60/246,610 United States of America 2000-11-08

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Cover Page Cover Page 118 2
Abstract Abstract 296 4
Claims Claims 165 5
Description Description 15,343 277
Drawings Drawings N/A N/A
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