Canadian Patents Database / Patent 2623964 Summary
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|(12) Patent:||(11) CA 2623964|
|(54) English Title:||USING METAL AQUACOMPLEXES FOR PREPARATION PURE AMINO ACID CHELATES FOR HUMAN AND VETERINARY USE|
|(54) French Title:||HYDROCOMPLEXES METALLIQUES SERVANT A PREPARER DES CHELATES D'AMINO-ACIDES PURS A USAGES HUMAIN ET VETERINAIRE|
|(51) International Patent Classification (IPC):||
|(72) Inventors (Country):||
|(73) Owners (Country):||
|(71) Applicants (Country):||
|(22) Filed Date:||2008-03-14|
|(41) Open to Public Inspection:||2009-09-14|
|(30) Availability of licence:||Yes|
|(30) Language of filing:||English|
A one-pot method for preparing water-soluble pure metal amino acid chelates in
chelate compositions using metal aquacomplexes is disclosed and described. The
obtained are free from other organic and inorganic additives including acids,
salts, and ions and
have high solubility and stability in aqueous solution. The pH of aqueous
solutions of chelates is
optimized for intestinal absorption by using different combinations of amino
acids as ligands.
The present invention establishes a process for providing a recommended level
of intake of
essential metals and essential amino acids by humans and animals by using
nutritional supplements or pharmaceutical applications.
Dans l'invention, on divulgue et décrit une méthode permettant de préparer des chélates hydrosolubles purs composés d'acides aminés et de métaux de composition variable à l'aide d'hydrocomplexes métalliques dans un récipient unique. Les chélates obtenus ont exempts d'autres additifs organiques et inorganiques, y compris d'acides, de sels et d'ions, et présentent une très bonne solubilité et stabilité en solution aqueuse. Le pH des solutions aqueuses de chélates a été optimalisé pour une absorption intestinale maximale à l'aide de différentes combinations d'acides aminés en tant que ligands. La présente invention établit une méthode permettant de recommander la concentration des métaux essentiels et des acides aminés essentiels aux humains et aux animaux en utilisant les chélates dans les suppléments nutritionnels ou les compositions pharmaceutiques.
What is claimed is:
1. A one-pot method for preparing pure metal amino acid chelates that are
water soluble and
stable in a range of pH of between about 3.8 and 9.7 and are free from
inorganic salts, inorganic or
organic acids, interfering ions in inner as well as in outer complex spheres,
consisting of these steps:
a) formation of non-water-soluble metal oxohydroxides, metal aquahydroxides
for di- and
trivalent metals, and carbonates or basic carbonates of divalent metals;
b) transformation of metal oxohydroxides, metal aquahydroxides of di- and
and carbonates or basic carbonates of divalent metals into aquaoxohydroxometal-
.alpha.-amino acid or
aquahydroximetal-.alpha.-amino acid by reaction in an aqueous solution with
.alpha.-amino acids with pI< 3.5,
while for copper it is also possible to use amino acids with pI >7.0;
c) subsequent exchange of molecules of water and hydroxyl groups in the inner
amino acids wherein the metal amino acid chelate has a ligand to metal molar
ratio of about 2:1, 3:1
d) evaporation of the aqueous solution of the amino acid chelate formed under
pressure and by drying of the obtained chelate.
2. A method as in claim 1 wherein the metal of the metal oxohydroxide and the
metal of the
metal aquahydroxides is selected from the group consisting of calcium,
chromium, cobalt, copper,
iron, magnesium, manganese, molybdenum, nickel, vanadium, and zinc.
3. A method as in claim 1 wherein said .alpha.-amino acid is selected from the
group consisting of
alanine, arginine, aspartic acid, asparagine, valine, glycine, histidine,
glutamic acid, glutamine,
isoleucine, leucine, lysine, proline, serine, methionine, threonine,
tryptophan, tyrosine, cysteine,
phenylalanine, and combinations thereof.
4. A method as in claim 1 wherein amino acid chelates of metals whose ions are
atmospheric oxygen are prepared under reduced pressure or in a nitrogen
5. A method as in claim 1 wherein amino acid chelates of metals whose ions
bonds with carbonate ions are prepared under reduced pressure or in a nitrogen
protect ions of the metals from contact with atmospheric carbon dioxide.
6. A method as in claim 1 wherein calcium is selected as the metal and the pH
of the final
amino acid chelate solution is less than 7.4, steps in claim 1(b) and 1(c) are
carried out in open air
conditions, while when the pH of the final amino acid chelate solution is
greater than 7.4, steps in
claim 1(b) and 1(c) are carried out under reduced pressure to protect the
reaction mixture from
contact with atmospheric carbon dioxide.
7. A method as in claim 1 wherein ligand exchange reactions for metals whose
aquacomplexes form hydroxo or oxo-hydroxo complexes by deprotonation of their
proceed in acidic solution to achieve pH < 5.7 by using only amino acids to
avoid formation of by-
8. A method as in claim 1 wherein the desired pH of aqueous solutions of amino
chelates is manipulated by using different combinations of amino acids as
ligands to create amino
acid chelates with high solubility and stability in aqueous solution in the
range of pH for optimal
intestinal absorption in humans and other warm-blooded animals.
9. A method as in claim 1 wherein the aqueous solutions of all amino acid
chelates having a
ligand to metal molar ratio of about 2:1 and 3:1, except in calcium chelate
solutions with pH > 7.4,
and calcium amino acid chelates having a ligand to metal ratio of about 5:2
are stable aqueous
10. A method as in claim 1 wherein a rate of the subsequent exchange of water
and the hydroxyl groups in the inner sphere by amino acids increases at the
temperature range of
from about 40° C to 80° C.
11. A method as in claim 1 wherein the metal amino acid chelates are used in
fields: food production, pharmaceutical and veterinary use.
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|(41) Open to Public Inspection||2009-09-14|
|Next Payment if small entity fee||2018-03-14||$125.00|
|Next Payment if standard fee||2018-03-14||$250.00|
Note : If the full payment has not been received on or before the date indicated, a further fee may be required which may be one of the following
- the reinstatement fee set out in Item 7 of Schedule II of the Patent Rules;
- the late payment fee set out in Item 22.1 of Schedule II of the Patent Rules; or
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|Fee Type||Anniversary Year||Due Date||Amount Paid||Paid Date|
|Request for Examination||$400.00||2008-05-02|
|Maintenance Fee - Application - New Act||2||2010-03-15||$50.00||2010-02-05|
|Maintenance Fee - Application - New Act||3||2011-03-14||$50.00||2011-01-04|
|Maintenance Fee - Patent - New Act||4||2012-03-14||$50.00||2012-01-13|
|Maintenance Fee - Patent - New Act||5||2013-03-14||$100.00||2013-03-05|
|Maintenance Fee - Patent - New Act||6||2014-03-14||$100.00||2014-02-27|
|Maintenance Fee - Patent - New Act||7||2015-03-16||$100.00||2015-02-09|
|Maintenance Fee - Patent - New Act||8||2016-03-14||$100.00||2016-02-11|
|Maintenance Fee - Patent - New Act||9||2017-03-14||$100.00||2017-02-09|