METHOD FOR MANUFACTURING A STABLE POWDER CONTAINING A VERY HYGROSCOPIC ACTIVE PRODUCT

PROCEDE POUR L'OBTENTION D'UNE POUDRE STABLE, CONTENANT UN PRODUIT A ACTIVITE HYGROSCOPIQUE TRES ELEVEE

English Abstract

ABSTRACT OF THE DISCLOSURE
In a method for manufacturing a stable powder from
a substance which contains in its molecule a rather precise
number of water molecules making the powder deliquescent
and unsuitable for distribution in hard capsules or in bags,
the step of crushing the substance is performed in the
presence of a finely pulverulent dry organic powder in order
to produce finely pulverulent homogeneous products which are
stable and able to he easily put in hard capsules or in bags.

Claims

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
l. A method for manufacturing a stable powder from a
substance which contains in its molecule a rather precise
number of water molecules making the powder deliquescent
and unsuitable for distribution in hard capsules or in
bags, comprising the step of crushing the substance,
characterized in that the crushing step is performed
in the presence of a finely pulverulent dry organic
powder in order to give finely pulverulent homogeneous
products which are stable and able to be easily put in
hard capsules or in bags.
2. Method according to claim l, characterized in that
the substance containing in its molecule a rather precise
number of water molecules and the organic powder are within
a ratio of 15:1 and a ratio of 2:1 by weight.
3. Method according to claim 1, characterized in that
there is used 12 parts by weight of crystallized hydroscopic
product which is finely crushed in the presence of l part by
weight of dry yeast of a very fine particle size.
4. Method according to claim 2, characterized in that
there is used 12 parts by weight of crystallized hydroscopic
product which is finely crushed in the presence of 1 part by
weight of dry yeast of a very fine particle size.
5. Method according to claim 1, characterized in that
3 parts by weight of the hydroscopic product in crystallized
form is finely crushed in the presence of 1 part by weight
of dry yeast of a very fine particle size.
6. Method according to claim 2, characterized in that
3 parts by weight of the hydroscopic product in crystallized
form is finely crushed in the presence of 1 part by weight
of dry yeast of a very fine particle size.
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7. Method according to claim 1, characterized in that
the organic powder is selected from the group consisting of
dry yeast, non-viable germs, flour, milk powder, meat
powder, fish powder and any other alimentary, dietetic,
medicamentous and cosmetic organic powder.
8. Method according to claim 2, characterized in that
the organic powder is selected from the group consisting
of dry yeast, non-viable germs, flour, milk powder, meat
powder, fish powder and any other alimentary, dietetic,
medicamentous and cosmetic organic powder.
9. Method according to claim 3, characterized in that
the organic powder is selected from the group consisting
of dry yeast, non-viable germs, flour, milk powder, meat
powder, fish powder and any other alimentary, dietetic,
medicamentous and cosmetic organic powder.
10. Method according to claim 4, characterized in that
the organic powder is selected from the group consisting of
dry yeast, non-viable terms, flour, milk powder, meat
powder, fish powder and any other alimentary, dietetic,
medicamentous and cosmetic organic powder.
11. Method according to claim 5, characterized in that
the organic powder is selected from the group consisting of
dry yeast, non-viable germs, flour, milk powder, meat
powder, fish powder and any other alimentary, dietetic,
medieamentous and cosmetic organic powder.
12. Method according to claim 6, characterized in that
the organic powder is selected from the group consisting of
dry yeast, non-viable terms, flour, milk powder, meat
powder, fish powder, and any other alimentary, dietetic,
medicamentous and cosmetic organic powder.
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Description

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-- 1 --
As known, some pharmaceutical products incorporate
substances which contain in their molecule a rather precise
number of water molecules, whieh makes them very difficult
to be kept for a long time due to the fact it i5 not
possible to include them in hard capsules or in bags.
Thus, their life in jars is very much reduced, particularly
in very humid countries, such as temperate countries or
countries in the equatorial areas.
Thus, in the past there has been used mechanical
means, such as vacuum wrapping means, but the cost is then
very high, and this increase in the price of the wrapping
means restrains the sale of the medicament itself which is,
generally, o~ an extremely low cost.
This is particularly the case when the medicament
contains hydrated calcium chloxide C12Ca, 6H2O or hyd:rated
magn~sium sulfate SO4~1g, 7H2O. Actually, these substances
are very hygroscopic in the open air and, if they are placed
without any partieular proteetion in hard eapsules, the
substance is modified and the capsule becomes soft, thus
requiring destruction of the medicament which is no longer
ingestible.
It has thus been proposed to introduce a dryinq or
desiccative powder in the active product which contains
water moleeules, and for this purpose there has been used
talcum powder or the like, but these substances have two
principal drawbacks, namely introduction of a mineral
material which is not without action on the gastric or
intestinal pH of the human system and also absorption of
the active substanee by the dryina or dessieeative powder
which makes it less available for the human system.
Accordingly, it is a general object of the present
invention to provide a novel and useful method for
manufacturing a stable powder containing a product with

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very great hygroscopic activity, in which the above described
disadvantages have been overcome. According to the present
invention there is provided a method for manufacturing a
stable powder from a substance which contains in its mole-
cule a rather precise number of water molecules making thepowder deliquescent and unsuitable for distribution in hard
capsules or in ba~s, comprising the step of crushing the
substance, characterized in that the crushin~ step is
performed in the presence of a finely pulverulent dry
organic powder, such as for example yeast, in order to give
finely pulverulent homogeneous products which are stable
and able to be easily put in hard capsules or in bags.
According to a preferred embodiment of the invention
there is used 12 parts by wei~ht of crystallized hygroscopic
product which is finely crushed in the presence of 1 part
by weight of dry yeast of a very fine particle size.
According to a further preferred embodiment of the
invention, 3 parts by weight o~ hy~roscopic product in
crystallized form is finely crushed in the presence of 1
part by weight of dry yeast of a very fine particle size.
Other objects and further features o the present
invention will be apparent from the following detailed
description.
As it has been stated above, the invention relates
to a method in which a substance containing in its molecule
a rat~er precise number of water molecules is reduced in a
fine powder in the presence of an anhydrous dry and finely
pulverized powder which can for example be a dry yeast, non-
viable germs, a flour, a milk powder, a meat powder, a fish
powder or any other alimentary, dietetic, medicamentous or
cosmetic organic powder.
Dry yeast is an alimentary organic material which
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is rich in vitamins and biological products useful to the
human system.
Experiments have shown that the ra-tio between the
hygroscopic product and the organic powder may be between
15:1 and 2:1.
Non 1imitative examples of the manufacturing method
1. 120 kg of crystalli7ed SO4PIg, 7H2O is finely crushed in
the presence of 10 kg of dry yeast of a very fine
particle size (i.e~, in a ratio of 12:1 by weight).
The mixture which is thus obtained can perfectly be
distributed in hard capsules and may be kept for years
in blister packs or in pill boxes.
2. 120 kg of crystallized C12 Ca, 6H2O is finely crushed
in the presence o 40 kq of drv yeast of a very fine
particle size (i.e., in a ratio of 3:1 by weight). The
mixture which is thus obtained can perfectly be
distributed in hard capsules and may be kept for years
in blister packs or in pill boxes.
The crushing step is performed by any suitable means
normally used in the art.