Note: Descriptions are shown in the official language in which they were submitted.
g~91'
This invention relates to a dentifrice which provides
effective stain removal.
; Some dentifrices are known which provide excellent foaming
with the use of the nonionic surface active agent block copolymer of
polyoxyethylene-polyoxypropylene with xanthan as gelling or binding
agent in which resinous poly~ethylene oxide) may also be present. The
dentifrice thereof typically contains a dentally acceptable polishing
agent such as a siliceous material; for instance, colloidal silica or
synthetic alkali metal aluminosilicate complex, that is, material in
which silica contains combined alumina.
Based upon prior art considerations, as disclosed in
United States Patent 3,020,230 to Smith, wherein silica material is
stated to coagulate or flocculate in the presence of resinous poly-
~ethylene oxide) in order to precipitate it from a liquid sus-
pension, one skilled in the dentifrice art would not have been
~ led to use silica materials in a dentifrice containing resinous
`~ - 1-
~ L7~'31
po~y(ethylene oxide). Indeed, in U. S. Patent 2,991,229 to
Ivlson, polishing a~entc or abrasivcs d1BC1OSed ln ~ tootll~astc
containing poly(ethylene oxlde) were "tricalcium phosphate, di-
cslcium phosphate and c~lclum carbonate and the llke"; but not`
sillca materialS-
It is an advantage of the present lnvention that a denti-
frice ls provided with lmproved stain removal which has'accept-
able cosmetic rheology and dentln abrasion characteristics.
It i5 a further advantage that deslrable foaming is achieved
with inclusion of polyoxyethylene-poly oxypropylene block copoly-
mer and xanthan in the dentifrice.
Further advaneages will be apparent from consideration of
the following dlsclosure.
In accordance with certain of lts aspects, this invention
relates to a dentifrice comprising about 20-80% by weight of a
liquid humectant vehicle, about 5-50% by welght of a siliceous
polishing material and about 0'.05-5X-by weight of a reslnous
poly(ethylene oxide), ~aid dentifrice containing florculated
partlcles of said ~iliceous polishing agent in the presence of
said poly(ethylene oxlde).
The proportion of the siliceous poli6hing agent content is
in the range rom 5% to 50% by weight of the dentifrice, prefera
bly f:rom 10% to'30% such a~ from 10% ~o 25X. One such polishing
sgent ls a complex alkali metal aluminosilicate having a re-
fractive lndex of from 1,44 to 1.47 and contalning at~least 70%
sllica, up to 10% alumina, such as about 0.1-10% e.g. about 0.1-
3%, preferably up to about 20% of moisture, ~uch as about 0.5-
10%; and up to Abo~t 107, of alkali metal ox-ide.- Typically, this
~aterial has a particle size in the range fram 1 to 35 mlcrons,
peferably from 2 to 20 mlcrons, e.g. 2 to 4 microns. The pre-
ferred moisturc content is from 10% to 20% measured by i~nition
at 1000C and the typlcal content of alkall metal oxide i8 from
5% to 10% ~!1
' I :L1S~1791
Generally, the polishing agent has a loose bulk density of up to
0.2g/cc, such as from 0.07 to 0.12g/cc. ~nothcr suitablc typc
of pollshing a8ent i3 porous amorphotls silicic anhydridc llnvlng
an average particle si~e preferably below 20 microns and above
l micron, a surface area of at least 200.m2/g, preferably at
least 300 m2/g, and a bulk density of at least 0.15 g/cm3,
preferably at least 0.30 g/cm3, such as a dehydrated sllica
hydrogel (i.e. a xerogel), preferably of ~he well known regular
density or lntermedlate density type. Examples af such amorphous
sillclc ~nhydrlde pollshing agents are "Syloid 63", "SyloId 72",
and "Syloid 74" ~SYLOID is a trade mark) which are described in
"The Davlson Family of Syloid Silicas" published by their.manu-
facturer, Grace9 Davison Chemical Company. "Santocel lOO" of
Monsanto (SANTOCEL ls a trade mark), is also a sultable dental
abrasive. "Syloid 77" has ~average particle size of about ~
microns, a surface area of about 340 m2/g bulk density of about
1.77 g/cm3. For "Syloid 63" the corresponding fi~ures are about
9 microns, about 675 m2/g and about 0.4 g/ ~3. A grade of
"Santocel lOO" has a surface area of about 239 m2/g and a bulk
density of about 0.24 g/cm3. These amorphous silicic anhydrides
may be used singly or in mixtures.
Resinous poly(ethylene oxide) has been disclosed as a denti-
frice gelling or b~nding agent in U. S. Patent 2,991,229 to
Ivison. Its prasence smoothed the texture of the dentifrice; -
indeed, the dentifrice of the present lnvention has a smooth
texture even thougn flocculated partlcles from the siliceous
polislling mncerlnl are prcsent.
The poly(ethylene oxides) employcd in thls invention are
~olid, colorlcss, wnter-~cluble reslns. Thcy nppear to form
homogeneous systems in water ln all proportions, although the
1~9~
relatively higher molecular weight ethylene oxide polymers merely swell
on the addition of small amounts of water. On the addition of greater
amounts of water, the polymers pass into solution. The water solutions
are viscous, the viscosity increasing both with the concentration of
the polymer in the solution and the reduced viscosity of the polymer.
The ethylene oxide polymers employed in this invention show little
change in melting point with reduced viscosity (an indication of
increased molecular weight) and the melting point, as measured by
change in stiffness with temperature, was found to be about 65 + 2C
throughout the range of reduced viscosities of from about 1.0 to about
10, and greater. These polymers, upon X-ray examination, disclose a
crystalline structure similar to that exhibited by polyethylene. The
crystallization temperature, as determined from measuring the break
in the cooling curve, is about 55C. To facilitate the understanding
of the instant invention, various terms will be defined. At the out-
set it should be noted that the word "poly~ethylene oxide)" as used
throughout the specification and claims refers to ethylene oxide poly-
mers which have a reduced viscosity in acetonitrile of at least 0.5 and
upwards to 75, and higher.
Unless otherwise stated, by the term "reduced viscosity",
as used herein, is meant a value obtained by dividing the specific
viscosity by the concentration of the ethylene oxide polymer in the
solution, the concentration being measured in grams of polymer per 100
milliliters of solvent at a given temperature, and is regarded as a mea-
sure of molecular weight. The specific viscosity is obtained by divid-
ing the difference between the viscosity of the solution and the viscosity
of the solvent by the viscosity of the solvent. The reduced viscosities
herein referred to are measured at a concentration of 0.2 grams of poly
(ethylene oxide) in 100 milliliters of acetonitrile at 30C (unless
stated otherwise).
Granular poly(etllylene oxi~c) rcsults from the suspcn~ion
polymerization of an agltated reactlon mixture comprising
ethylene oxide in contsct with a polymerizatlon catalyst therefor
and in the presence of an inert organic diluen~, e.g., heptane,
in which ethylene oxide is soluble and the resulting poly(ethy-
lene oxide) is insoluble. Granular poly(ethylene oxide) thus
produced is obtained i~ a finely-divided solld particle state
and resembles finely-divlded san~ ln particle size. Unlike the
granular poly(ethylene oxide) resul~ing from the suspension poly-
merization process, the bulk and solutlon polymerizatlon processes
yield a polymer whichis.asubst2ntially homogeneous mass either
conforming to the shape of the reaction vessel or, after drlv~ng
ofEthe org~nic medium, for example, by mechanical extrusion, e.g.
Marshall ~Sill (undar vaccum and at sl.ightly elevated temperatures) .
resembles l~yers or sheets. This polymer subsequently can be
reduced in particle size, for example, by dicing or the like.
The term "granular" rPfers to the particle size of the
ethylene oxide polymers prepared by suspension polymeri~ation.
A granular product is one whlch is ln a free-flowing statP and
comprlses partlcles averaglng les~ than 5 mesh in size (U. S.
St~ndard Sl~e Sieve).
The poly(ethylene oxide) comprises ahout 0.05-5% by weight
of the dentifrlce, prefersbly 8bout 0.1 - 1.5X.
In the dentlfrice, the ~iliceou8 polishlng agent flocculntcs
in itu in the presence of the poly(ethylene oxi~e). Thc
~loccula~e~ particles typical.l~y may agglomcrate with each othcr
have apparent pnrtlcle slzcs Up to about 250 micron~ or morc,
typlcally nhollt 44 to ~77 n-icron~; ln o~her words, ~he flocculnte(l
particles typically pass through a screen of U' S. Sleve No. 80
and nre retained on a screen of U. S. Sleve No. 325.
31
In spite of the presence of the flocculated particles the
dentifrice is readily formulated to have a desirable appearance
¦and a rheological texture without an undue "lumpy" appearance or
"gritty" feel.
The liquid vehicle of the dentifrice comprises water,
humectant or mixtures thereof in amount of about 20-80%, prefera-
bly about 30-60%. When a substantially visually clear gel ls
desired, water is generally not present in amount abo~e about
10% typically about 2-5%. When the dentifrice is opacified,
greater amounts of water may be present. Typical humec~ants
include sorbitol (as 70% aqueous solution), glycerine, maltitol,
xylitol, polyethylene glycol ~00 and polyethylene glycol 600.
Most preferably the dentifrice contains about 25-50% maltitol.
Maltitol may assist ln improving stain removal when present in th
dentifrice of the invention. It is noted that maltitol is disclo
sed as a dentifrlce ingredient in Japanese Patent Publications
73110241 and 65/15120.
The liquid ~ehicle and gelling agent including resinous
poly(ethylene oxide) and other components of the dentifrice are
proportioned to form a cream or gel mass of desired consistency
which is extrudible from an aerosol or pump container or a col-
lapsible tube (for example aluminum, lead or plastic~.
In addition to the resinous poly(ethylene oxide), further
gelling or binding agent such as sodium carboxymethyl cellulose,
Irish moss, xanthan and the like may be present in amount of
about 0.5-7%. Xanthan is preferred. The total amount of gelling
or binding agent in the dentlfrice can be about 0.1-12~ by weight
~ nthan gum i8 a fermentation product prepared by action of
the bacteria of the genus Xanthomonas upon carbohydrates. Four
epecle6 of Xa l monos, viz. X. cam~etrl:. X. ~ li, X.
~6- .
, ' ,' I
. ~L~gi~79~
malvocenrum, ancl . carotne are rcportccl in thc literaturc to be
the most eEficicnt gum producers. ~lthou&ll the exnct chem~cul
~tructure is not determined, it is generally accepted to be a
heteropolysaccharide with a molecular weight of several million.
It contains D-glucose, D-mannose and D-glucoronic acid in molar
ratlo of 2.8:3:2Ø The molecule contalns 4.7% acetyl and about
3% pyruvate. The proposed chemical structure configuatlon can
be found in McNe21y and Kang, Industrial Gums, ~d, R. L. Whistler
Ch XXI, 2nd Edition, New York, 1973. The procedure for growin~,
isolating and purifylng the xanthan gum is found in ~anufacturing
Chemist, May 1960, pages 206-208 (inculding mention at page 20~
of potential use o gums therein described ~or formulating toor.h-
pastes).
Use of special grades of xanthan gum, such as describPd in
U. S. Patent No. 4,263,399 are withi~ the scope of this lnvention
A grade described in U. S. Patent 4,263,399 i5 A xanthan gum in
which up to about 1,6% of the carbo~yl groups are bound to cal-
cium and tlle remaining carbo~yl groups are bound to sodium,
potassium, a mixture of sodium and potassium or other non-calcium
catlons.
The dentlfrice may contain an anionic, nonionic> cationic
or amphoterlc surface active agent to achleve incrcased prophy-
lactic DCtiOn, assist in acllievin~ thorough an~ complete dis-
persion o~ the instant compositions in the oral cavlty and
ren~er tl~o ;nstant compositions more cosmctlc;llly ucceptal-le.
A pre~erred sur~nce actlve ngellt i~ u nolllolllc block cvpo~y-
mer containing po1.yoxyethylene anll polyoxypropylelle. Such block
co~olymerR nre nvni]nble from Wyan(lotte ~:hclllicAls Corp. under
the trade mark "P]uronic". They mny be iqui-l, paste, or solid
and are g~nerally chemically defined in terms of the molecular
weight of the polyoxypropylene hydrophob~c moiety and the percen
by welght of the polyoxyethylene hydrophilic moiety.
_~_
L91791
The following block copolymers are available from Wyandotte:
PLURONIC Pl~YSICAl. MOl.. Wl`.
NUMBER CHARACTER HYDROPHIL HYDROPHOBE .
L 121 LIQUID 10 4000
L 101 LIQUID 10 3250
L 81 LIQ~ID 10 2250
L 61 LIQUID 10 1750
L 31 ~I~UID 10 950
L 122 LIQUID 20 4000
L 92 LIQUID 20 2750
L 72 LIQUID 20 2~5~
L 52 LIQUID 20 1750
L 42 LIQUI~ 20 1200
P 123 PASTE 30 4000
P 103 PASTE 30 3250
L 63 LIQUID 30 1750
L 43 LIQUID 30 1200
P 104 PAST~ 40 3250
P 94 PASTE 40 2750
P 84 PASTE 40 2250
L 64 LIQUID 40 1750
L 44 LIQUID 40 1200
P 105 PASTE 50 3250
P 85 PASTE 50 2250
P 75 PASTE 50 2050
P 65 PASTE 50 175n
L 35 LIQUID 50 950
F 127 SOLID 70 4000
F 87 SOLID 70 2250
F 77 SOLID 70 2050
F 108 SOLID 80 3250
F 98 SOLID 80 2750
F 88 SOLID 80 2250
F 68 SOLID 80 175
F 38 SOLID 80 950
. .
The preferred ncnionic block copolymers are solid (or flake)
materials and the mo~t preferrdd are Pluronic 108 (80YD polyoxy- ` .
ethylene: 3250 molecular weight polyoxypropylene~ and F 87 (70%
polyoxyethylene: 2250 molecular weight polyoxypropylene).
Othor noniolllc ~nrfnee actlvc tl~ l`ll~S Whl.('ll IlI;ly ~ OyCd
include condensates of sorbitan monofiterate w~th flpproximately
20 ~olés of ethylene-oxide. Amphoteric agents include qu~terni~ed
imidazole derivatives which are available under the trademark
"Miranol" such as Mira'nol C2M.
::'
. -8-
19~L7'11
Suitable types vf anionlc detergents are water-soluble salts of
higher fatty acid monoglyceride monosulphates, 9~1Ch as the sodium
salt of the monosulphated monoglyceride of hydrogenated coconut
oil fatty acids, higher alkyl sulphates, such as sodium lauryl
sulphate, alkyl aryl sulphonates, such as sodium dodecyl benzene
sulphonate, olefin sulphonates, such as sodium olefin sulphonate
in which the olefin group contains 12-~1 carbon atoms, higher
alkyl sulphoacetates, higher fatty acid ester of 1,2-dihydroxy
propane sulphonates, and the substantially saturated higher
aliphatic acyl amides of lower aliphatic amino carboxylic acid
compounds, such as those having 12 _16 carbons in the fa~ty acid,
alkyl or acyl radicals, and the like~ Examples of the last men-
tioned amides are N-lauroyl sarcosine and the sodium, potassium,
and ethanolamine salts of N-lauroyl, N-myristoyl or N-palmitoyl
sarcosine, which could be substantially free from soap or similar
higher fatty acid material whic~ tends to substantlally reduce
the effect of these compounds. The use of these sarcosine
compounds in dentifrice compositions of the present invention
is particularly advantageous since these materials exhibit a
prolonged and marked effect in the inhibition of acid formation
in the oral cavity due to carbohydrates bre~kdown in addition to
exerting some reduction in the solubility of tooth enamel in
acid solution.
Cationic surface active germicides and antibacterial com-
pounds such as di-isobutylphenoxyethoxyetllyl dimethyl benzyl
ammonium chloride, benzyl dimethyl stearyl ammonium chloride,
tertiary amines having one fatty alkyl group (of from 12-18
carbon atoms) and two (poly) oxyethylene group~ attached to the
nitrogen (typically containing a total of from about 2 to 50
ethanoxy groups per molecule) and salts thereof with acids, and
-~ 1~1791
and compounds of the structure.
(~1~12CH20) 1~ /(C112C1120)"11
R-N-CH2CH2CH2N (cH2cH2o)yH .
where R is a fatty alkyl group containing from about 12 to 18
carbon atoms, and x, y and z total 3 or higher, as well as salts
thereof with mineral or organic acids, may also be used. It is
preferred to use from about 0.05 to 5% by welght of the foregoing
surface-active materials in the instant dentifrlce.
An alkali metal fluorine-providing compound may be employed
in the dentifrice of the invention. The alkali metal fluorine-
providing compound includes-sodium fluorlde, potassium fluoride,
lithium fluoride, ammonium fluoride and complex fluorldes, par-
ticularly alkali metal monofluorophosphates. These compounds
I exhibit satisfactory retentions of soluble fluoride in denti-
fri.ces of the instant invention. In particular, the level of
retention of monofluorophosphate ion as fluoride with the alkali
metal monofluarophosphates is quite high. The fluorine-containing
compound is employed in amount which provides an effective non-
toxic amount of fluorine-containing ion to the dentlfrice typicall
ab~ut 0.01-1% by weight pre$erably about 0.1% fluorine. Thus,
sodium fluoride i~ typically employed in-amount of about 0.02-2%
by weight, preferably about 0.7%, and sodium monofluorophosphate,
Na2P03F, in amount of about 0,1-7.6% by weight, preferably about
0.76%.
The alkali metal monofluorophosphates which may be employed
include sodium monofluorophosphate, lithium monofluorophosphate,
potassium monofluorophosphate and ammonium monofluorophoisphate.
The preferred salt is sodlum monofluorophosphate, Na2P03F, whicl
. ' ,. Il
~ i -10- ,- i
.j j . .
,.~
119179~ 1
..
.
as commercially avallable, may vary considerably in purity. It
may be used in any suitable purity provided that any impurities
do not substantially adversely affect the desired properties. In
general, the purity is desirably at lease about 80%. For best
results, it should be at least 85%, and preferably at least 9070
by weight of sodium monofluorophosphate with the balance being
primarily impuritiPs or by-products of manufacture such as sodium ¦
fluoride, water;soluble sodium phosphate salt, and the like. I
Expressed in another way, the sodium monofluorophosphate employed¦
should ~a~e a tot~l fluorlde content of above 12%9 preferably
12.7%; a content of not more than 1.5%, preferably not more than ¦
1.2% of free sodium fluoride; and a sodium monofluorophosphate conl-
tent of at least 12%, preferably at least 12.1%, all calculated
as fluorine.
Other monofluorophosphate salts which may be used in the
instant invention include monofluoropolyphosphates such as
Na4P309F, K4P309F, (NH4)4P30gF, Na3KP309F, (NH4)3NaP30gF and
Li4P30gF-
. I
:.~ . . I
~ ~ l
1~L9~7~1
Antibacterial agents may also be employed in the oral pre-
parations of tlle instant invention to provlde a total content of
such agents of up to about 5~ by welght. Typical antibacterial
agents lnclude
Nl-(4-chlorobenzyl)-N5-(2,4-dichlorobenzyl) blguanide;
p-chlorophenyl biguanlde;
4-chlorobenzyhydryl blguanide;
4-chlorobenzyhydrylguanylurea;
. N-3-lauroxypropyl-N5-p-chlorobenzylbiguanlde;
l-(lauryldimethylammonlum)-8-(p-chlorobenzyldlmethylammonlum)
octane dichloride;
5,6-dichloro-2-gunnldinobcnzlmldnzole;
N -p-chlorophenyl blguDnldohcxanc;
. 1,6-bis~2-ethylhexyl blguanldo) hex~ne;
5-a=ino- , -bl~(Z-e ehy lhexyl)- 5-e ethylhctahy~r~pyr(ml~ c;
-
.
.
.
-12-
l~
~ 791
.
and their non-toxic acid addltion fialts~
Synthetic finely divided pyrogenic silica such as those
sold under the trademarks Cab 0-Sil M-5, Syloid 244, Syloid 266
and Aerosil D-200 may also be employed in amounts of about 1-5%
by weight to promote tbickening or gelling of the dentifrice.
The taste of the new compositions may be modified by
employing suitable flavoring or sweeten$ng materials. Examples
of suitable flavoring constituents include the flavoring oils,
e.g. oils of spearmint, peppermint, wintergreen, sassafras, clove9
sage, eucalyptus, marJoram, cinnamon, lemon and orange as well as
methylsalicylate. Suitable sweetening ager.ts include sucrose,
lactose, maltose, sorbitol, sodium cyclamate, perlllartine, and
saccharine. Suitable flavor agent may comprise from about 0.01
to 5% or more of the compositions particularly when anionic
surface active agent is present ~n the instant invention.
Various other materials may be incorporated in the dentifric
formulations of this invention. Examples thereof are coloring or
whitening agents or dyestuffs, preservatives, silicones, chloro-
phyll compounds, ammoniated materials such as urea, diammonium-
phosphate and mlxtures thereof, and other constituents. Thcse
ad~uvants are incorporated in the instant compositlons in amounts
which do not substantially adversely effect the properties and
characteristic6 are deslred and selected and used in proper amoun
depending upon the partlcular type of~preparation involved.
'1`11~ 1 r r ~ 1 V ~ n ~ r~lc~ic~ f~-r ~ . A
~oderaeely acid to alkaline pH is preferred.
The following specific examples are further i]]ustrativ~-of
the nature of the present invention but is understood that the in-
vention is not limited thereto. Dentifrice formulations are pre-
pared in the usual manner and provide in situ flocculation of the
siliceous polishing material~ and all amounts and
` ~91'791
proportions are by weight except as otherwise indicated.
EXAMPLE 1
The following opacified gel dentifrices are prepared:
PARTS
A B
Maltitol (75% solution) 40.00 40.00
Sodium aluminosilicate ~silica
containing about 1% combined
alumina - Zeo 49B-Huber~ 18.00 18.00
Pluronic F 108 Block Copolymer 3.00 3.00
Xanthan 1.70 1.70
Polyox WSR 301 ~Union Carbide) 0.20
Titanium dioxide 0.40 0.40
Flavor 0.50 0.50
Sodium saccharin 0.20 0.20
Deionized water Q.S. T0 100 Q.S. T0 100
Polyox WSR-301 is available from Union Carbide Corp. as
granules of water soluble poly(ethylene oxide) resin having a
molecular weight of about 4,000,000 and a Brookfield viscosity of
1650-3850 cps. ~25C, spindle 1, speed 2 rpm) when in water at 1% by
weight. Likewise, similar foam and feel is attained when other
; 10 water-soluble poly~ethylene oxide) resins available from Union
Carbide Corp. as Polyox WSR-N-10, WSR-N-80, WSR-N-750, WSR-N-3000,
WSR-205 and WSR 1105 replace Polyox WSR-301~ in different concen-
trations. Polyox is a trademark.
Both dentifrices provide stable full-bodied foam with
good mouth feel; the mouth feel of dentifrice A being particularly
satisfactory.
When compared for ability to remove dental stain and in
dentin abrasion, dentifrice A containing the Polyox material removes
more stain with less dentin abrasion than dentifrice B, without Polyox
material. In dentifrice A, flocculated particles of sodium alumino-
silicate form in situ.
- 14 -
,
Thc rcsults nrc n3 follows:
" rl.R('.l.~lT RADlOACTIVli.
DENTIFRIC~ STAIN Rl.~OVAI. DENTI~l Al~l~ASTON
A 35 14
22 39
In a stain removal test, sectlons of human dental enamel are
etched with 0.1N~lCl for 2 minutes, rinsed wltil water, then wet
with a dilute solutlon of stannous fluorlde, wiped dry, and
finally exposed to a stream of hydro~cn sulfldc ~ns whi~ rcYiults
ln the deposlelon of a brown deposit of stannous sulfldc. Thc
amount of stain on the surface ls measured with a Gi3rdner Auto-
matlc Color Dlfference meter. The surface is then brushed wlth
a ~echanlcal br~shlng machine for 5 reciprocal strokes wlth
a slurry of a dentlfrice and the residual staln measured with
the meter. Finally, the stain which remains is completely removed
wieh dental pumice and the reflectance of this surface is read.
The ability of a dentifrice to remove-the stain is expressed by
the following equatlon.
Percent stain removed = (Rd500 strbkes ~ Rdinitial) loO
pumiced ~ Rdinitial
where Rdinitlal, Rd500 strokes, and Rdpumlced are respcct1vely
the re1ectance vslues me~sured on the inltially Yitained surfaces
~; after brushlng for 5'. seclprocnl strokes and after removing the
resldual stnin by pumicing.
~he RDA values are obtained by a procedure base~ on a radio-
i acti~e technlque descrlbed ln the llterature; Seookey, C. K. and
Muhlcr, J. C., J. I)cntal Rcucnrcll ~7 524 -538 (19fiB); Hefferren,-
J. J.,J. Denta ese~rch 55 56~-573 (1976).
. ' ,,i ..
~ -15-
, ~
~ -- ~L9~791
` EXANrLE 2
: The followln~ dQntlfrlces ~re prcpared:
PARTS .
MaltitDl (75% solution)40.00 40.00
Sodiu~ alumlnosll~cate (sllica con-
taining combined about lZ combined
alumlna-~eo 49B - Huber)18.00 18.00
Calcined alumina 5.00 S.00
. Pluronic F-108 3.00 3.00
: Xanthan 1.70 1.70
: Polyox WSR 301 t~nion Carbide~ 0.20 -- .
Titanium dioxide 0.40 0.40
Flavor 0.50 0.50
Sodium saccharin 0.10 0.10
: Deionized water ,Q.S. to 100 Q.S. to 100
.
Both dentifrices provide stable full-bodied foam with good
mouth feel; the mouth feel of dentifrice A being particularly
sa~isfactory.
The followlng stain removal and radioactlve dentin abrasion
results were obtained with dentlfrices A and B, evidencing
superiority for dentifrice A, cont~lnin~ tl)e Polyox matcrlDl wlth
~: ~ rc~ard to higher st~ln removal ~ltll simil~r dcntin. abr~s.ion.
. . .
~` DENTIFRICE PERCENT STAIN RE~IOVAL R~A
1~7 4
-16-
. , '' .
,'
1~ 1191791
EXAMPLES 3-4
The Eollowlng opaclfied gel dentlfrlccs are prepare~I:
EX~MPLES
3 4
Glycerlne 10.01~.0
Maltitol 15.015.0
Sodium aluminosilicate (silica
combined with about 1%
combincd alumlaa) Zeo 49B
~luber) 18.0l~.n
Pluronic 108 block copolymer -- 3.0
Sodlum lauryl sulfate 1.0 --
Xanthan 2.02.0
Polyox WSR 301 0.20.2
Sodlum monofluorophosphate 0.76 0.76
Titanlum dioxide 0.40.4
Low menthol flavor -- 0~5
Peppermint oil flavor 0.5 -- ~
Sodium saccharin 0.2 -- j
Color solution (lX5 0.05 0.05
Water Q.S. to 100 Q.S. to 100
The dentifrice of E~ample 3 wlth sodium lauryl sulfate has ¦
deslrable Eoam character. The dentifrlce of Example 4 also has
very good stable full-bodied foam character even though no
anlonic surface actlve ag`ent 18 employed. The foam remnlns I
throughout the oral cavity, wl~h deslr~ble mouth fecl, when thc
~entiErice i8 bru6lIe~ onto tlle teeth. Morcover, lt has no bltter
note even though low menthol f-lavor is present and no sweetener
l~ add~d. The dentlfrices have fine smooth ~exture and arpe~rnnc
effectlvely remove staln and have acceptable dentin abrasion
character. They contain flocculated particles of sodium alumino
sllicate. ~ ;
.. . : . . ~ .. . .
~l ll9~L791
: Although this invention ha~ been described wlth regnrd to
ill~lstrative examples, it will be apparent to one ~killed in the
art that variou~ modification~ may be made thereto which fall
within its scope.
-18-
.. . . . : : . .
