Note: Descriptions are shown in the official language in which they were submitted.
CA 02015079 1999-08-OS
TITLE OF THE INVENTION
Chemical Disinfectant and Sterilant
PRIOR ART PATENTS
3,915,877 10/1975 - Ware - 252/106
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4,208,404 06/1980 - Cowan - 424/153
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4,469,614 09/1984 - Martin - 514/705
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4,654,374 05/1987 - Martin - 514/698
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BACKGROUND AND SUMMARY OF THE INVENTION
This invention is an improvement over the chemical disinfectant and sterilant
composition disclosed in my U.S. Letters Patent No. 4,469,614 and U.S. Patent
No.
4,654,374.
This invention relates to antiseptic and germicidal compositions and in
particular to
disinfectants and sterilants. Specifically, it relates to chemical
compositions for use as
disinfectants and sterilants.
There have been many compositions, developed for antiseptic and germicidal
cleaning
purposes, but each in the prior art has had some limitations as to the
applications. For some,
the limitation has been the extent to which they could successfully disinfect.
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For others the limitation has been the extent to which
they could consistently sterilize. Still others were limited
because of the toxic effect on the skin or other organs of the
user. Other compositions were limited because of their
corroding effect on metal, such as spotting or tarnishing.
The present invention has been developed to avoid or
overcome these prior art limitations especially in the general
use solutions of the disinfectant and sterilant. This is
particularly so when used as a disinfectant and sterilant for
inanimate objects.
The present invention has many uses for disinfecting or
sterilizing hard surfaces, such as counter tops, laboratory
tables, laboratory equipment, hospital walls, and other such
hard surface items or areas in medical, surgical or dental
environments as well as for industrial, commercial, and
agricultural purposes and uses.
The disinfectant and sterilant of the present invention
is specifically intended as a means of fighting organisms that
cause disease and have industrial products. The disinfectant
and sterilant may be used in laboratories, operating rooms,
patient-care rooms or areas, and other similar places in
public or private facilities such as schools, hospitals,
homes, factories, and similar locations.
The disinfectant and sterilant is intended for use to
eliminate bacteria. that is found on hard surfaces as
aforementioned. The use of the present invention may be for
application by spraying, wiping, rinsing, dipping, brushing,
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or by other methods of application.
The basic ingredients of the formula for the disinfectant
and sterilant composition, which is delineated in detail
hereinafter, is composad of glutaraldehyde, ortho phenyl
phenol, paratertiaryamylpher.ol, sodium arylalkylsulfonate, and
citric acid. The plurality of chemicals is mixed as a
solution.
The disinfectant and sterilant is provided as a stock
solution, thereafter, in activated form, it is diluted with
water ir. various proportions or ratios depe~:ding upon t'..~.e
level necessary to achiave a specified a~.d result. This is
discussed in detail hereinafter.
Of aarticular r_ota is the fact that in the prior art the
use of glutaralde;yde has usually been in the alkaline for:,,
whereas iz the present invention the use of glutaraldehyd~ is
in the acid form. Previous acid forms pol~-merize and therefor
lose effectiveness.
Th= prior art disinfectants in the zlkaline solutions
tend to leave a residue in the more concentrated forms. This
cauld be an irritant. Several rinses may be required to
remove the slippery residua.
The present invention is primarily for use as a
disinfectant and starilant on inanimate surfaces for
' disinfection and sterilization of contaminated areas. For
example, on dental or surgical instruments that are
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contaminated.
As a secondary use, the present invention may be used in .
a milder form, by dilution, as a hand disinfectant in health
case offices, laboratories, and treatment rooms, or in more
concentrated form.
The normal pH range for the disinfecta_-:t and sterilant of
this invention is 3.0-3.5, however, under controlled
circumstance s the range may be 2.5-7.0; as the disinfectant
and sterilant must be acidic, it cannot b~ over pH 7Ø
As noted, the present invention uses the glutarald'hydes
in t?~° acidic form. In the prior art the glutaraldehydes in
the al~cal?re form present certain disadvantages. Some of
these disadvar.tagas are: it needs ar. activator of a sp=cial
solution or powder to make it active: once activated, it tzen
has a li::!it~d lifa oa one to four :~.eeks and mist be disposed
of entirely; the composition, ~.ahic~: is normally activated in
approximate amounts of a lire r, is uneconomical if not used
because it is dated at time of activation and rust be
discarded; th= solution yellows the skin due to a tanning
action; it has a disagreeable odor; it is corrosive and acids
polymerize and lose potency.
In the present invention, the acid foz-m of the
glutaraldehyde needs no activation and has a morn or less
indefinite shelf life of close to one year. The solution of
the present invention permits mixing and diluting just the
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amount needed, thereby preserving the stock solution which
makes it more economical. In this manner it does not need
dating, for the mixture being used is only what is needed.
In the prior art the corrosion of instruments (~nhen used
for dental and surgical instrument disinfection or
sterilization), the tanning effect on the skin, irritation of
the skin and allergic dermatitis to the skin, its noxious
odor, general toxicity, and the tarnishing of carbon steel
instruments were all undesirable problems. The present
invention overcomes these problems.
The pr=sent invention has a much wider and universal use
than the disinfectants and sterilants of the prior art which
were limited because of the prior a=t problems. The present
invention may be used on and for all hard surfaces tha~ are
non-porous. Hard surface items include catheters, scalpels,
trays, bowls, dental mirrors, lights, and other similar
equipment. Even cotton. swabs may be soaked in it and then
used t~o disinfect.
The formation of the present invention can be used in
industrial areas, such as oil industry recovery, for iron and
steel cleaning, for damuliszfection, degreasing an,3 janitorial
work.
In 3eneral use the present invention may be used for
instrument immersion, wiping surfaces and instruments,
dipping, and spraying (by pump or aerosol means).
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The present invention may also be used by placing
instruments in a tray containing the disinfectants and
sterilar.t in diluted solution form. This includes all medical
and other health care arrangements, including veterinary,
podiatry, hospital, nursing, and other health care facilities
or laboratories. Cages for laboratory animals and the
laboratory areas may be disin~~cted with the present
iw~entio~. In household use the present inve-:tion may be used
where ordinary sprays are used, such as in toilet bowls,
animal areas, and kitchen areas. The present invention is
effecti-Ye or. ite:;~s t::at cannot be heated or autoclaved, and
includes rubber and plastics items.
It is to be noted that the corrosion: of iron and steel in
th2 iOr.:~ Of. StOra7e tonkS, p?p21 ineS, p'1~p5, dnd Ot:'ler
systems by sulfate reduci.~.g bas;,teri a and pseudor~onas type
bacteria particularly is a serious problem faced by the
petroleum industry. These bacteria also cause impede the
secondary recovery ofpetroleum. Several general measures
hava bezn t3'.K?n by the industry to prevent these effects.
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One method has been to employ biocides to kill the
bacteria. However success has been variable. The biocide can
be incorporated in the oil formulation or the end use may be
diluted down to suit a particular need. It usually has taken
several hours for the biocide to work in the wells or tanks.
This is a severe down time problem and it has been found
that the biocides wire not completely effective being unable
to get beneath a sludge level to attack the sessile organisms.
The problem of penetration of the sludge biofilm inhibits
present biocides. The use of a biocide to disrupt the biofilm
and kill the bacteria as well as prevent reattac ~~ent is the
important factor to reduce this problem.
The new formulation of 25~ glutaraladehyde plus the dual
synergistic phenols are sufficie~.t based upon testing to equal
the benchark biocide, which is a 50o concentration oT
glutaraldeh,,~de. The solution of this invention coupled with
the special surfactant/detergent/solubizer component enables
the biofilm to be penetrated and removed thus allowing a less
toxic formulation to penetrate, attack, and kill the
particular organisms present.
Therefore the invention of this formulation acts as both
a cleanser and disinfectant, thus combining two key attributes
into or.e product and is morn effective than the higher
concentrations of single components. This biocide is stable,
at selected temperatures and starts to polymerize at high
temperatures, shortening its life but increasing its killing
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effectiveness.
In one of the milder forms, the present invention may be
used in soaps for degerming the hands or as a presurgical
lotion as a hand degerming agent.
It is, therefore, an object of this invention to provide
a disinfectant and sterilant that is a chemical composition.
Another object of this invention is to provide a
formulation that can be effectively used in industrial,
commercial, and agricultural areas to kill sulfate reducing
bacteria that are specific to corrosion proble,s in the oil
producing business.
Another object is to product a formulation which will
clean as ~~:ell as disinT'ct the wall head and holding tanks and
reservoirs and will main=ain itself in the field and will not
polymerize leading to premature loss of activity, all due to
the low pH of the formula_ion.
It 's another object of this invention to provide an
invention that can be used in industrial situations requiring
cleaning and disinfecting at a higher concentration.
It is another object of this invention to provide a
disinfectant and sterilant that may be used on had sur~ace
inanimate obj=cts.
It is also an object of this invention to provide a
disinfectant and sterilant that may be used on living tissue.
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It is yet another object of this invention to provide a
disinfectant and sterilant that fights organisms that cause
disease, and industrial destruction.
It is still another object of this invention to provide a
disinfectant and sterilant that uses glutaraldehyde in acid
form.
Further objects and advantages of the invention will
become more apparent in light of the following description of
the preferred embodiments.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The formula of the present invention for a chemical
disinfectant and sterilant is as follows:
s
glutaraldehyde (acidic) 57.06%
orthophenyl phenol 1.32
paratertiaryamylphenol 0.27$
sodium arylalkylsulfonate 0.16$
citric acid 0.10$
water 41.09$
TOTAL (By Weight) 100.00%
The above formulation is the base stock solution and when
used, as hereinafter described, it is diluted and/or
concentrated. The base stock solution is the concentrated
form and it is further diluted or a higher concentration with
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water for clinical or general use. The percentages are by
weight of the ingredients to the total weight of the mixture.
It is to be noted that the aforementioned stock solution
is shown as a liquid solution, however it is to be understood
that the reduction or trans'ormation to a dry powder state as
a dry base stoc'.~c che:~ical compound, for subsequent dissolving
in wate r or other suitable solvent to form the base stock
solutio:~, is within the scope and intent of this invention.
It is also to be understood that the mixing of the
formula without the ;~;ater contEnt as a liquid base stock
chemical compound, for subsecuent addition of tha water
conte:~t to ferm the base stoci: solution; is also within ti~.e
scope and intent of this irver_ti or..
The for:r.slation o~ the aforementioned chemical
disinfectant and sterilant in a dry base stock che-t'cal
compound a:~d in a liquid base stock chemical conpound are
means by which economical storage and shipment can be obtai.ed
in relation to the aforementioned base stock solution which is
of groaLer volume.
T:~e glutaraldehyde in tha formula is in acid form with a
preferred pH range of 3.0-3.5. however, a pH range of 2.5-7.0
is possible and useable un3~r controlled conditions. The
glutaraldehyde for this invention must be acidic and,
therefore, must not exceed a pH of 7.0 in that regard the
range slightly below the pH of 7.0 is desirable, say S0~ to
10%.
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The glutaraldehyde has 258 concentration
chemical
compound, mixed into the formulation in weights, or
percentages of the total weight, as noted ereinbefore.
h The
formulation given previously es of the total
by percentag
weight for each ingredient, by actual weight
are shown below
of each ingredient for the formulation:
Ingredient Weight Percent of
(grams) Total Weight
glutaraladehyde (acidic) 2156.25 57.06
orthophenyl phenol 50.00 1.32
paratertiaryamylphenol 10.00 0.27
sodium arylalkylsulfonate 6.00 0.16
citric acid 3.80 0.10
water 1553.00 41.09
TOTAL 3779.05 100.00
The citric acid removes a noxious odor and provides
additional acidification.
The concentration of glutaraldehyde which can be used in
the basic formula ranges between 10~ and 50~ glutaraladehyde.
Thus, the range of concentration of the active ingredients can
be from two times the concentration listed to one half the
concentration of the active ingredients: Acid
glutaraladehyde, orthophenyl phenol and
paratertiaryamylphenol. The rest of the ingredients follow
the same usage as in my U. S. Patent No. 4,654,374 issued May
31, 1987. This formula omits benzotriazole.
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To activate the chemical disinfectant and sterilant for
use, the base stock solution is diluted in controlled ratios
with water. The range of the solution can be 50o glut to 10~
glut. A strong solution would be 25$ glut ar.d a weak solution
10~ glut.
The determination of the ratio to use may be determined
by test for the wide plurality of applications which exist.
The sodiun arylalkysulfonate acts as a surfactant and
corrosion inhibitor.
The weights for each ir.gredier.t, and thei_ corresponding
oerce~taces of tze total wei7ht of the r.ix=ure, are for the
optimal formula and ore'erred e;:,bodimer.t of the invention of a
cremical disinfectant and sterilant. iiocae~.~er, it is to be
under rood tzar vari~tior.s from this optical formula of up to
plus or minus ten percent of each weight are ~.~oricabla and sre
:aithia the scope and intent of this invention, any difference
in tote l weight being adjusted in the water content; the
percentages by weight being adjusted accordingly. Thus, the
formula ~'13s a range of weight for each ingredient with the
optima l and preferred embodiment being as specifically listed.
The rarga for phenols hatches the ratio as glutaraldehyde
increases or decreases.
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This improvement is made possible by the fact that the
disinfecting and sterilant agent glutaraldehyde is enhanced by
the synergistic action of the two phenols (orthophenyl phenol
and pa=atertiaryamyl phenol) which are interactive and
additive, making the sum greater than any of the parts.
As can be readily understood from the foregoing
description of the invention, the present structured
formulation of a chemical disinfectant and sterilant can be
further structured in different modes of formulation to
provide an ability to disinfect and sterilize objects.
Accordingly, modifications and variations to which the
inve:tio=, is susceptible may be practiced withost d?parting
from the scope and intent of the appended claims.
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