Note: Descriptions are shown in the official language in which they were submitted.
21645~2
- ~A ~vice and Me~hod for Suction-~ressure,Iniect'Ion-'
- - inc-lud'ing a System of -its AFjply
The invention relates to the medical technique, dealing
especially wit~h the treatment of diabetics with insulin.
First, the invention is founded or, the o~7er p~essure or
jet injection which came into fashion in 70's and was
keept until 1983 for mass inoculation practice.
On the ore hand the irritations of the skin through repiti-
tive use was caused by tissue lacerations, because the in-
lG jection nozzle WGS pressed against the skin in a tissueccm,cressing manner.
In the Patent Application DE P 37 30 469.0 this need
was f~lfilled. The present application shall ~emove a
further cause of violent skin irritation: That is, the
remains of drug and desinfectant residues in the
i~jection channel of the skin.
Until the glucose measuring by means of laser rays
through the skin is practically realized -which could
p~ofit by t~ blood emptiness in the s~ction cup- the
purpose of cl measurement through~the eye ccrnea is still
er,riched by the inventive improvement of performing such
measurements by means of a special spectacles, which
places the measuring arrangement in the depth of the or-
bi,t a~tomatically. Even there gaining of singular meas-
ured values during the day is ccnsidered as burdensomefor the patient as the permanent body ccntact of a meas-
uring device. Such metabolism measured values there are
understood to be offered (generally cable less) to
the ccmputer in the injector for evaluation and registra-
3~ tion to guarantee the tctality of the therapeutic system.The more sluggisch metabolism in the eye chamber gives
the inducement to watch for other pcssibilities of an
injury-less metabolism control as supplementation.
The habituation on a d~ily urin sampling ccn be stimulat-
ed by suitable a~xiliary means. But also the supplemen-
tation of ar: injection by a separated injection of a kind
of sensor bristle, m~inly inside of a suction cup, cculd
be useful. _ 3 _
C~ 2164582
The production of sensor cannulas, that is to say, of can-
nulas inside of which a sensor thread is shoved under the
skin, is comparatively expensive, mainly exclusively for
measuring purpose. Additionally, the sensor thread must
be held particularly thin, because the cannula shaft or
cover destines the diameter ard this even could be lower-
ed to a diameter of 0,32 mn,. The main purpose for the
treatment remains a painless and minimum invasive intro-
duction of the sensor.
With this application, the functions of a suction injector
s~ould be automatized sc far as possible. As arother unre-
nuncable scope is set that one to open the lid over the in-
jection nczzle which has an air tightened seat first imme-
diately before the drug administering. Otherwise, drug fluid
s~!ould be able to be sucked dc,wnward through the injection
nozzle still before the injection into the suction cup space
under the influence of negative air pressure ir the suction
cup. In SUC}I a manner not only the metering could be incor-
rect, but also air cc,uld enter from the suction cup space,
inspite of the weak vacuum there-, into the injection cylin-
der space. That cculd possibly interrupt the inection beam.
The necessity of a ccntainer as well for the thinning fluid
ac for water for the cleansing causes an enlargement of
the apparatus, for w~iat which encountering was
necessary by space saving on other places in all functional
fields.
-- 4
~ 216~582
Prior Art
Propcsal was made to measure t~le glucose ccntent before
the eye lens through the ccrnea by the application of a
special contact lens (March, Wayne Front, P 22 38 9&5;
U'; 3,958,560 M~y 25,1976).
The "device fcr the destination of the surface centre of
an illuminated hc,le" refers remotly to the pIoposal
for focusing spectacles. (Digital Systems Inc.Arc.Cal.
Ind.William Marautelte, DE 25 36 380). Nils Kayser
(P 26 06 991, Febr.20,1976) has filed laser measur-
ements including of glucose through a tongue spatula.
Arno Mueller attempted it through the lobe of the ear.
Wire less transmission of dcsages and vices found on
Prestek K.and Franzeski M.(DE 30 35 670) as well as by
Fishel and Ellentuch (P.32 47 233). Also to be mentioned
are the numberous jet stream injectors, as DE P 30 30 671
filed by Hoechst and Mc Kinnon, Charles Neal (Bioject.
Inc.Euro Publ.0 427457A2), which is supplemented in this
2G invention with the suction cup and a step syringe, and
means for cleansing of the injection channel.
In addition to the over pressure or jet stream injec-
tion within a suction cup which I filed in DE 37 30
469.0, proposals for a kind of sensor bristle or capil-
lary in a puncture grip are made in Euro Pat.Appl. Nr.
0 301165 (published Febr.1,1989). But these sensor ele-
ments were introduced into the bcdy by an accompanying
lancet or car.nula, which should dilate the injury un-
der the skin by swinging mc,vements or rotations for a
blood sampling, whereby in a special case, the measuring
zone was tIansferred to the lancet shaft itself (Fig.59,
12). A skin squeezing mechanism is demonstrated in Fig.
61. The efficient introduction of a small s~nsor between
the skin and muzzles, also in a humide area, is inten-
ded with the invention now presented at nearly any bcdypart.
~ 216g~82
Summary Of The Invention
The proposed task is sc:lved in an example by the emptying
of separated piston-cylinder pumps through a common noz-
zle. Caused by an electrical circuit contact, the pres-
sure donator, here, a cclenoid or pressure spring,
for the second piston in the cylinder with the skin af-
finitive or friendly fluid, is tr-iggered shortly be-
fore the first cylinder with the drug is emptied, so as
lG the pressure beam is not interrupted.
The task of the determination of the triggering of the
point of time can also be solved by a ccmputer oriented
from the a~;ount of drug which is administered to the
first cylinder. According tc metering one is fallen back,
only for example, to the step syringe (the "pen" sy-
stem), to avoid detours w~ich are not customary in the
trade.
Du.ring the storage period and during the drug apply in-
to the cylinder, the nczzle is closed by a lid which
2G has a sealing ring toward the ar~a of the nozzle and
incandescent wire loop, which is embedded in ceramics,
the heating of which by current application causes the
evaporation of the water residues or. the area of the
nozzle. This lid also prevents the air eccaping through
ore of the two cannulas after the pa.ssage of a flap
for each of the t~o mounted toward the metering (or injec-
tion) chamber on the end of the cylinder, bu.t which
takes place after the rinsing out of said air by means
of tissue friendly fluid. Thereby the sa.id lid, of course,
serves for prevention ar.d killing of pathological
germ settlement. The c~-linders are closed toward the
pressure dc,nator by a sealing membrane between the pump
rod ar;d the cylinder ledge or rim for the infection pre-
vention.
In the second example, two pi.stons are arranged or.e be-
hind the other inside of a ccmmune cylinder. The drug is
placed b~fore the first piston, as the rule twc scrts
-- 6 --
21~82
of drugs are used, namely immediately working or regular
insulin and depot insulin in different dosages. But skin
friendly flaid is also still filled-in before the drug ap-
plication until the piston ledge openings are disappeared
above in the cylinder and therewith sealed. The space bet-
ween the two pistons is filled up with tissue friendly
fluid through the pcsterior piston. When the pressure
dcnator is activated (it could also be a sc;lenoid
as in the first example), the first piston, subsequent
to the drug, is driven toward the nczzle by the main
a~ount of the tissue friendly fluid. As soon as the pi-
ston ledge openings are free, tissue friendly fluid pene-
trates exceptionally from the interpiston space into the
interstice before the nozzle, which is left, finally,
nc. mc,re by drug. A chamber-nozzle cleansing is provided
at last after each use by means of an injection (or
better:ejection) stroke with clean water. The change be-
tween tissue friendly fluid and clean water is achieved
by valve or three-way-cock.
The second example fell back upon the mechanique as it
WG~S derivated from a toy auto ard described in f~rther
details in DE P 39 25 940.4.
The demonstration of the power way from the electric motor
through different rigid and flexible shafts and toothed
wheels on detail was therefore dispensed with, because
that would be possible to ary skilled expert withcut
difficulty.
Because the scope of the invention, of ccurse, is a
pocket pcrtable flat shape, the drug e~;pelling cylinder is
hcrizontally mounted and the nczzle is deflected on the
end of the cylinder about 9O degrees from the c~-linder
axis. It is also possible to stratify dr-ug ard tissue
friendly fluid inside of a hoselet without separation
in a ~cinner as today chemical substances are portioned
ir the laboratory -even though separated by air bubbles.
If that is dc,ne quiet immediately before the injection,
the mixing through of both fluids will be a desired in-
-- 7
216~82
~,
cc,mplete or.e; also a strong p~essure donator (perhaps a
piezzoelectric one) can reach the effect of a rinsing
out of the skin.
The proposed task of ar avoiding of suction influence to-
ward the nczzle is solved by assigning a ~echanism forthe opening of the lid over the injection nozzle immedia-
tely inside the space with negative air pressure in the
suction cup.
This lid favorably clings a klind-like kind of leaf spring
lG to the erd of the injection cylinder. This can be dis-
placed now as well in a vertical motion as in a radial ore
out from the area of the injection nozzle by means of a
wedge slantily by a lever or directly -as by a bowden wi-
re. B~t a ccrresponding drug passage opening in the blind
cam provided is brought in a cGincident position with the
injection rozzle shortly before its function. A nozzle
which frontaly leads out from the injector c~-linder, if
nczzle and blind axis lay excentrically or a sectoral gap,
exists in the blind.
2G A kind of sector blind can also-be turned past the nczzle
by
an axis in the suction cup roof. The a~ditional tasks pro-
duce special difficulties: namely, to keep the nozzle
clean by means of a heating device after the injection;
2~ but mainly the necessity of an optical control of the skin
with regard to the aptitude for the puncture and this just
or. an area where the skin clings. The jet beam can thereby
also be led obliquely inside of the skin knob, because it
however depends or the lengthening of the distance, the in-
3G jection produces a nearly hcrizontal projection from thesuction cup edge; in such a manner a particularly near and
secured skin contact takes place~ but slight pressure
staggerings can do nothing against this.
To keep the area of the nczzle clean with heating, a kind
of second blind can be fitted over the just decribed one,
which contains heating wires. The advantage of such a
~unctional division is that the second blind or cover can
-- 8
- 2164~2
be thicker shaped and can yet be turned or lifted out of
the functional area before the skin is drawn up.
The optical survey can still occur in the raising place of
the skin. In particular if a higher capacity of the ccm-
puter of the electric and electronic control unit is in-
stalled. In this case the natural skin field structure
or patterns can be used as a kind of scale and the re-
flexion quality (the reproduction of brightness) of the
skin area, as it can be ascertained perhaps on a window in
the suction cup edge, can be converted to the area which
lies before the nozzle. With such a computer analysis,
spotted skin cclouring (perhaps with freckles) can be ccn-
sidered. The duration and velocity of the skin pattern mo-
tion are q~oted acurately for such a (arithmetical) con-
versionEven a pigment poor zone of the skin can be steered for
the injection over an electronic ccntrol of a ventilation
throttle for the suction cup, without the need to break
off before the process of sucking of the skin and without
need tc repeat it.
The minimum demand to an optical skin control is reached
with the comparison of the brightness of the injection
area and ar adjacent or,e, still suitably by the proceed-
ing uce of device. (Thereby one can be placed on the op-
tical glucometer as customary in the tr-ades). In a special
solution, the light ray is projected from the suction cup
rocf to a kind of mirror nose on the nc,zzle blind. After
the reflexion on the skin, the ray path leads back to the
sensor. The mirror ncse is moved away from the nozzle be-
fore the injection. The measuring can also occur by alight ray w~iich projects from a light ccnductor end
near the nczzle. In this case, the measuring and the ela-
bcration of the result must be effected in the intervall
between the blind opening and the injection.
Further features of the invention relate to the sort of
pr-essure donator for the injection rod, the injection cy-
linder, and injection piston shape for avoidance of pol-
g
C 216~582
lution in a permanent operation of the device, and the mech-
anical gear cc,ntrol as well as the container shape.
Besides the treatment of diabetics, the device can be
used for the administering of other drugs. It should be men-
tioned here the periodical heparin injection for the aim of
thrombosis prevention. The insulin cartridges were chosen as
metering device, as they are broadly customary in the trade
with so-called pen-systems, but one could use also any other
metering systems. Stack ccntainers in row, that are folded
bellows, are described as alternative for the employment of
ste~ syringes. The cannula, which serves for the cc,mmunica-
tion to the next cc~ntainer, can be removed. A folded meter-
ing chamber or, the foremost ccntainer, which is connected
with the drug inlet opening into the injection cylinder, de-
ivers the drua in the total of single dc,sages. For that,
the metering chamber is impulse-like, ccmpressed by an ec-
centric gear or solenoid.
A water container was to schedule, because the metering pi-
ston and (metering) cylinder as well as the nc,zzle had to
be cleaned after each injection fro~ the salt of the thin-
ning fluid (shortly: thinner). Thinner and water are suitab-
ly stored in high elastic containers and cGmbined in an ex-
change-container unit. Because also in this case no amount
of air should enter into the closed fluid system during the
container exchange, these elastic cGntainers must be beared
in a further rigid cc,ntainer and must be exchanged in the
said one. The inner ccntainer are suitably set under gas
pressure in a further ccntainer of the device. This is orly
allowed for the short period of the filling u~ of the in-
jection cylinder or of the cylinders; in any case, such a
timely limitation seems to be suitable for the purpose of -
keeping the valve ecluipment simply.
-- 10 --
~_; 216458~
Preferred fittings of the thinner and water cGntainers
consist of tw~ folded bellows, which are separated one from
other inside of a plastic or pasteboard cylinder by the pcr-
tion wall of the latter. Therefore, a kind projecting collar
5 edge ir the middle of the pasteboard cylinder is pressed
against a ccntainer seal. The two afflux connnecting pieces
for gas are firmly installed in the device container w~ll.
The derivation of thinner respective water takes place from
the folded bellows through cannulas which are connected with
10 hoses. The former pierce the stopper membranes in the centre
of the cGver cap, which can be screwed on, and from the cen-
tre of the bottom of the uptaking device ccntainer. The se-
curity of the injection cylinder or the c~-linders on the in-
troduction side of the piston against pollution is effected
15 by a roofing over with a membrane or a folded bellows.
The filling UE of water or other fluid in the interstite
between protective membrane or folded bellows and the rear
piston face is a new procedure to prevent the injection spa-
ce against ar er.trance of air. For an er.abling to diminish
20 the a~ounts of auxiliary fluid (thlnner) and water, if smal-
lest drug dosages are used, a amount or dc.sage limitation is
introduced also for these. The limitation is approximately
ccnversly proportional to the drug dosage. (A too frequent
necessity for a cGntainer exchange or too big a volume load
25 of the device wculd otherwise be the consequence). The dos-
age limitatior is preferably brought about here over a screw,
which activat~s after the back mc,vement (or lifting) of the
metering pistcns, and this is done through the roof of the
protective folded bellows ard thightened to that.
30 When the cGntrol gear, in the here preferred linear arrang-
ment, returns after the injection, the dcsage limitating
screws are sunk again into their injection cylinders.
(The gear should not work to the screw the insulin car-
tridges, as long as they are nct yet emptied or should be ex-
35 changed).
-- 11 --
~ 21C4582
In nearly each case, thinner is mixed to the c~-linder space,
destined for the drug, so as the smallest dosages still can
be turned into an injection beam.
A pressure gas source can be used as pressure donator in one
S example for each injection cylinder of the device. Two strong
pressure springs, one for each injection cylinder of the de-
vice (namely one spring for the drug thinner mixture and the
other for thinner which washes the skin out), serve for a
pocket portable device dealed with here. The pressure springs
are lifted to produce a strong but slow mction mcment through
one or t~o wedge slides into their stop catch. The latter is
bolted by a release fork. The release fork again is shot up
by means of an auxiliary spring.
In an examplarv solution the shortening (or lengthening) of
the switching distance in a Bowden cable opens the blind
before the nc,zzle still before both metering pistons with
ccnnecting straps between p~essure spring and injection cy-
linder are released. The injection distance for both cylin-
der can be adjusted by a slide (bar) which partially cGvers
2C! a release slot or the release fork, w~ereby this operation
is coupled with the metering and adapted to the filling
a~ount in the ~njection cylinder. Another solution uses
three solenoids for direct stroke for the triggering of the
three functions. But all three and further functions can also
be operated by ore solenoid only by means of a rotation
mechanism for a drum with ccnducting grooves (a thrust-tor-
sion-mechanismj which causes a partial rotation with each
stroke. The sw tching periods can still be essentially
shortened by tensioning a tension spring during the stroke
in a certain angled position of the hammer (connected with
the rod of the solenoid). A rotating disk with sectorally
radial passage can free the hook on the cross bar of
the tension spring at ary desired functional phase for
switching purposes.
- 12 -
21fi4~2
The activation delay of the sclenoid can be under bitten
in such a way. (Frequently smelts with rotation mechanism in
ball
pens for the blocking of the w~-iting lead to a similar ex-
planation).A gas jet pump is used for the negative pressure production
in the suction cup. For the handy device, manual pressure
is exerted against four pressure springs, guided in four
tube sockets at the housing corners toward a kag which lies
behind a separated ccver sheet. The produced over-pressure
is transmitted through a valve to the container for the fol-
ded bellows wi~h thinner and water during the drug metering.
Because the bag is broadly cGnnected as well with the lid
as with the cover sheet of the hcusing of the device,
its reexpansion produces a suction after the stop release
of the four pressure springs, the suction being effective
through the before mentioned valve in the suction cup.
The functional security pcstulates a short switching period
between the raising of the skin in the suction cup and the
injection release. When this was not produced by a special
sc;lenoid, this task was solved by attaching the release c~
s-;ction and injection to the same operation wheel. The
latter still works against a spring during the suction re-
lease in twc examples. This period remains up to the over-
2~ ccming the pressure pcint, that is sudden change of the mO-
ximum spring tension for the decision for the injection on
the electronic control unit or part -according to the infor-
mation o~-er the skin contact by cGntact-switches immediately
ncar the nozzle, and according to a foavourable result of
the optical skin control. The spring accelerates then the
phase of the injection release. But the release operation
can still be interrupted before the turning over of the
pressure over the pressure or summit point.
- 13 -
~ 2164~B 2
A centrifugal switch for the switching over comes intoquestion for two separated functional blocks - for a series
of special operations- anyone of the ccnsiderable number of
variations for the ccntrol gears.
5 A roll which has a switching pin (or slide) in a radial bore
is driven by an electrical mctor. It depends or. its velo-
city during the first rotations if the pin or sleeve is
fixed or the inner axis-up to the er.d of a spiral inner
groove-by a spring or by permanent magnets.
lGwith a high velocity, the switch pin or sleeve er.ters, out-
side the roller, the worm formed groove guidance of the outer
cylinder which surrounds the roller. The mctor power is trans-
ferred then (in the related wcrking direction) either to
the inner axis or to the outer cylinder, the rotation of
15W~iCh is mediated to separated functional blocks.
As an alternative, a three gear unit is demonstrated. Ter-
minal thrust mctions, produced by a screw, are thereby
t~ansferred to a control pinion of each functional block
by means of a bar. The driving wheel or ccntrol pinion is
2Gshifted along the square motor axis -tracing the trans-
mission toothed wheels for the reduction of the number of
revolutions- one after another into the mesh with three
operation wheels for the functional blocks.
This shifting ~cvement is rendered possibly over an over-
25bridging sleeve of the control pinion axle as a prolongationof the motor axis. It is limited in each case by- a cross cam
peg inside of a switching sleeve stationary to the shifting
direction, the cam peg being guided in a slanting inner
groove of the sleeve. The groove has nctches which corres-
3C~pcnd to its meshing position between control pinion andoperation wheel, which hinder the cam mc,tion. Thè latter
falls in a counter notch w~.ich hinders the return into its
exit position with a slight rotation by the slanting of
this ccunter notch under the influence of a pressure spring
35which counteracts to the cam movement.
- 14 -
216~82
'_
The cam is shoved i~to the next higher stop notch with anrenewed sliding mc~vement of the bar by the carriage of the
last cc,nnected functional block in the final wcrking phase.
After t~o such shiftings, the cam falls back over a steep
flange of the groove with following longitudinal groove
in the switching sleeve into the exit position. The shift-
ing mc,ment of the bar is maintained to reach the proper ef-
fectiveness of the carriage movement of the next functional
block by an additional toothed wheel which is shoved up to
the bar and ccntrol pinion on the ccntrol pinion axle, sepa-
rated from the control pinion by a pressure spring. This too-
thed wheel has naps toward the ccntrol pinion which ~lesh with
naps of the w~:ile ore touches the other, and the toothed
wheel rotates freely around the axle. The additional tooth-
ec wheel is t~en taken, by the pinion. If the pressure fromthe bar releases, the additional toothed wheel, which trans-
itory enlarges the pinion functionally, leaves its nap mesh-
ing with the pinion by working of the leaf (or pressure)
spring between the additional toothed w~eel and the pinion
2G until a new bar shifting by the carriage of the next func-
tional block in its final phase is produced.
The transport of the bar by the carriage -finally also the
motor driven screw- takes place, for example, by leaf spring
with wave pro-ile, on which the cross stay of the carriage
temporarly rests durlng its passing over.
Another sclution allows a springing pin to mesh on a carriage
between the teeth of a toothed w~eel (if only moving in
ore direction of a ratched wheel) and effects a partial ro-
tation of the latter during its passing over.
Both devices can also serve for the release of lid stops,
tension stops for a squeezing device etc., over levers
and tow lines. Especially, release operations can be also
produced electrically by ore or mc,re solenoids in their re-
spective traction functions.
The function ccntrol of the mechanical gear unit results
electrically ~:ver ccntacts
- 15 -
216~582
mainly or. the toothed wheels for the electronic control unit.
Thereby, additional contact tracts arranged along to a slid-
ing screw way can induce the mctor to running in staccato,
to combine an altogether quick thrust mction with precision
of the choice for the final point, perhaps in metering.
This acceleration of the running up is of i~portance mainly
then, if the filling of the injection cylinder with the
drug occurs fi-st during the skin contact. This can be suit-
akly done for an alteration of the dcsage in the last second,
lG but on the other hand a trace of thinning fluid can be de-
livered out of the nozzle toward the passing past skin
with the aim to reach an airless metering of the insulin
w~:ich is now admixtured.
In other words. the dislocation of the injection or
e,ection nozzle into the area of the suction cup edge is
very advantageous. The injection distance without tissue
ccntact is particularly long but without the choice of an
oval o~tline for the suction cup along the injection direc-
tion. Such an arrangement even can save an opening mechanism
2G for the lid blend which ccvers the nozzle or it can simpli-
fy this. (The blind cGnsists, in an inventive example, of
a ring which is shoved u~ward by the skin itself and on
which the opti-~al control device also terminates).
Wher the nozzle lies already in the level of the damming
up or upsettin~ area of the skin, then it is already closed
up by the skin before the negative p~essure works in the suc-
tion cup; during the suction, the skin passes the nczzle per-
manently sealing the same. This process can be observed by
means of a special window by light measurement. Light c~n
3C~ be projected thereby from an angular or bent las or trans-
parent plastic surface to the skin, b~tt especially
it c~n be reflected in a radial projection to the nozzle and
from there transmitted to the sensor for measurement or
ascertainment.
- 16 -
~_ 216~5~2
The electronic control unit, respectively the computer is
abled to attach the okserved skin parties with the nczzle
in respect tc its pcsition according to the skin patterns
. ar;d to put it in relation to adjacent or ealier stored
measuring results of the skin surface by comparing the
brightness. But the pcsition of the skin before the nozzle
can be shoved by influencing a nozzle or valve between the
suction cup and the outer air in such a manner as to avoid
ar injection into skin areas with suspected reflexion valu-
10 es. If a "leak" of the suction cup space is planned-in from
the beginning -but bcfore the reventilation- the selection
of the injected skin area is effected by the choice of the
mc,ment of injection. The same arrangement (e~-entually also
additionally) can be made for the skin selection for measur-
15 ing use, because measured values can be transmitted to theinjector nc,t or.ly through cables, electromagnetic or acous-
tic waves from outside -perhaps as glucose measurements by
laser through the skin from outside-, but such measurements
can also take place inside the s~ction cup.
20 The registration of functional dates is nearly sufficient
ard ensues again suitably in connection with the charging
device for the battery from the mains.
With regard to the programming of the device one cc,mes back
to the sc;lutio~ ways as they are given in PCT/DE85/00113.
25 The rings, which serve for program adjusting and w~ich
were rowed one akove other are now replaced by knobs which
are rowed side by sede along one device edge (better:
wall). A locking up knob is here also scheduled to release
the allowed decisions of the user in steps.
30 An improvment in the direction of an increase of liberty for
the live style consists of rendering possibly to sui-
table users, to adapt also the dosages of depot insulin to
the respective ccurse of day, that means a daily new pro-
gramming. A screen raster of sensor contacts on a housing
35 broadside is therefore provided, supplemented by an -eventu-
ally interrupted- fluid display ledge, which demarcates about
a half or full day interval starting from the actual clock
- 17 -
216~82
time. The patient is ncw able to indicate his intendedfood uptake also with regard to the glucose contents re-
spectively in triangle shape by means of spreading the
sensor contacts classed with the intended time interval.
Illuminated diodes are suitably classed therefore to ma.ke
the choice visible. The glucose contents cc.rresponds then
to the breadth of the above standing t~iangle base, to the
distance of the triangle pcint below the velocity of the
glucose resorFtion. The extent of bodily activity is ex-
10 pressed in la~eral rectangles time cc.ordinated in watt.Exceeding from actually measured glucose tissue levels and
with cGnsideration of the input of individual working con-
stants of insulin, the height and the mixture relation of
the insulins are now made coincidently and are administered
15 by the cGmputer, unless it is not necessary to warn aqainst
absurdities.
During the contact of the device with the charging device
from the mains, the installed printer reproduces meas-
ured values, patient inputs and delivered dosages in numkers
20 and graphics, and it permits the control.
The optical skin control can be er.sued also through a mi.rror
over the nozzl.e or. a blind which is then drawn off. A heating
spiral is alsc suitable for the environment of the nozzle,
the former being eventually cGnnected with the blind and
25 capable of being shoved away before the injection.
An optical skin ccntrol is also important at the device
before puncture. It can be directed, for example, from the
suction cup roof through a mi.rror toward the injection
area, but can also be effected through light ccnducting fi-
30 bers, nearly parallel, near the cannula shaft (her: -
nczzle).
Mainly advantageously the o~tical skin ccntrol is under-
taken by a kind of blind visor with a central hole near
a suction cup edge, so that the suction has still enough
35 elasticity to enter into this hc,le and to build a little
buble against the pu.ncture area, where a light beam runs
tangentially through the smal skin bubble to the sensor.
- 18 -
2164~8~
The customar~7 urine sugar control causes a~ inconveniencemainly in the form of the day profile (or sampling), be~
cause a large collecting ccntainer must be carried along
everywhere. For that we recommend to urinate into a little
folded sack directly over the toilet. The sack is then ccr
corded up above and hung on a spring-balance, w~;ich can be
integrated in the device, transferring the respectively as-
certained weights, as approximate urine volume data di-
rectly to the computer and data store. A customary test
10 strip is ins--rted then into the sack bcttom~manufactured),
SG that its free end can be grasped from outside. The sack
is opened below by tension on a prolongated belt or this
free end of the test strip after a clock alarm; the sack is
thereby emptied into the toilet. The test strip can be tied
15 off from the sack through a draining sheath, and a~ optical
brightness ccntrol in the device can be directly transmit-
ted to the cGmputer.
Eventual sugar contents of the single urine sample are cal-
culated, but also the averidge sugar contents of all samp-
les after the last meal, input by the patient, and the su-
gar concentration of the urine from 12 resp.24 hours.
An addition~l test strip parameter, perhaps for urea, can
be employed for the ccntrol of the correctness of the
sampling.
But a sensor bristle, resp.a sensor thread, can be shot ~
through the s~in ~r~ the sl~ction cup ec~ge for ~ '_isC~le
sugar measurement, which consists of material w~,ich can be
reabsorbed. The bristle or thread can then be shoved fur-
ther along into the subcutaneous tissue. (The entrance of
the sensor bristle is rendered possible by a high initial
speed similar to fluid just also for a flexible material).
At first, the thread must be embedded into a kind of chuck
similar to a drill, with the aim to be able to pusch it
with the chuck in the longitudinal direction without a
_ 19 _
216~582
~"
lateral evasion of the thread. But the sensor thread can
bc likewise produced as a drill with helical threads or.
its front end and can be led under the skin through a skin
pore with rotation by means of such a drill chuck,
perhaps by a weak rubber tube (end) with big walls, which
is ccmpressed. For a further thrust, either the thread
reserve is beared inside of a folded bellows on a kind
of cross cdisks or or. supporting struts which project from
wall segments of a longitudinal slotted plastic sleeve
nearly touching one another. The latter are driven
asunder with the wal 1 segments of the sleeve one after
other by ccne. The point of the cone is connected with the
end of the sensor thread, while the cc.ne base has a kcwl
or nap for uptaking the gLiding pin for the thread thrust.
Because a cannula wall is saved, if a sensor bristle is
used, the latter can be produced scmewhat thicker by meet-
ing with the endowing of chemicals for influencing of the
current and with the apply of a o~tern protective sheat
against a diffusion of the c~emicals into the body. (The
2G skin which is thinned by the strétching during of its
raising, eventually supported by adhesive or squeezing
means, reduces moreover the extent of the scar by the
injury). The arrangement for the introduction of a sensor
bristle can be suitably coupled with the eguipment with a
nozzle for the pressure or jet injection in one suction
Material which can be reabsorbed are preferred, there-
fore, because the breaking uc of a sensor thread can ne-
vermore be excluded before by technical distubances before
the retreat of the thread. The use of polymerizated tere-
3CI phthale acid ard polylactacid is proposed to w~ich themeasuring active substances (as NPD-GCD-Perid for the
active ard sepharose-convaline-A for the passive electri-
cal sensor) can be bc,und. Mainly, the pclylactacid has
distinct hygroscopic properties, which is important for
the uptake cf tissue fluid. The threads or filamenta of
the molecule can be turned as a drill before they are
ccated with a protective film (perhaps with polycarbona-
- 20 -
~_ 2164~82
te). In this way a kind of drill cculd be produced.An introduction of measuring substances into the body
could be avoided, if a ~easuring thread which is not en-
dowed with such substances cculd be shoved under the skin
(a thread perhaps of silk, which is hardened for short
time by formaldehyde of 2 to 5 per cent). The thread can
be retrieved, if it is saturated with (body) fluid, into
the hose end, and the ccntained glukose can be brought in
reaction with the measuring layer, which is
inlet in the bore of the hose er.d.
Threads which are endowed with a measuring layer contact
a metallic ccat inside of the hose end after being
retrivied therein. The current ccnduction to the measuring
instrument is performed by the respective wires. If there
are twc ccnductive zones longitudinally separated,
the hose end must be secured against rotation because
of the closing of electrical contacts (perhaps by deri-
vations of the diameter from the circular shape).
The device for the introduction of a sensor bristle can be
operated also with a ~as pressure-capsule. For the driv-
ing of the sensor thread or bristle under the skin by the
gas pressure beam, the bristle er.d must be enlarged and
stopped at a narrowness on the end of the supporting slee-
ve. The current measurements can also be done outside of
the (supporting) sleeve between piled UF, stacking sheets
after the sensor thread is drawn back from the skin. (This
can be done but also here inside of the sleeve if the re-
spective metallic coating interior is present with contact
derivation outwards).
If a ~etabolism measurement (of any interesting substance,
as glucose, kut also cholesterol ar,d others)
is chosen by the reflex optical way with use of colour
changing agents, two very s~;all cylinders c~n be punched
out of two different reaction surface sorts customary to
test strips. Two of these respective cylinders are then
stuck together in such a way, that bcth colcjur reactive
~ - ?~1 -
2164~82
layers bound the total cylinder each or. or.e side. Thetotal cylinder consists mainly of hygroscopic material
(ac kieselguhr or silicagel). Such a reaction cylin-
der can be firmly stayed onto a carrier thread or pin and
still even pricked into the skin, w~!ereby the thick car-
rier works like the disk o a drawing-pin. The metabolism
measurement is performed after the input of the carrier
thread by laser scanning on both ends; on the carrier side
suitably through a (central) bore or channel of that.
The arrangement for the introduction of a sensor bristle
can be suitably ccupled with the e~uipment for the pres-
sure injection in one suction cup, those fittings facing
then one with other. When the period for the saturization
with tissue liquid can be held shortly enough, an additio-
nal squeezing device, perhaps by means of two slides resi-
lient one against other, can be saved. The pressure injec-
tion otherwise ensues with a new sucking on after the me-
tabolism measurement is completed. But the diagnosis with
the sensor thread can also be transferred into a separat-
ed device hc~using. If pulver inj2ction of solid drugs(perhaps in crystalized ccndition) is applied, pressure
gas replaces the "washing out" fluid for the injection
channel .
A measuring cannula can also be introduced ur!der the skin
into the liquid sea over the muscle skins or fascia.
The cannula consists of a capillary which is drilled in
or shot in. Such a capillary can be also endowed outside
or inside with a measuring layer for metabolism measure-
ments and it can also serve for the injection of fluids
(after the measurement). But the capillary wall can be
punched ard serve the drainage of tissue liquid toward
a measuring zone in the sleeve for the capillary; additio-
nally, of ccurse, to the injection of the drug or medication.
- 22 -
~_ 2l64~82
- The mentioned chuck for the mc~tion of the thin sensor brist- lqor thread consists perhaps of a thick walled soft rubber
tube or hcse end which is compressed by pressure in a longi-
tudinal direction. For the further advance, the thread re-
serve is stored either inside of a folded bellows or' a kind
of cross disks between the fold depressions or on support-
irg stays, which nearly meet in the center and project from
the wall segments of a longitudinally slotted plastic
sleeve. The supporting stays are driven asunder, one af-
ter the other, with the wall segments of the sleeve bya cGne.
The point of the cone is connected with the end of the
sensor thread, whilst the cone base has a bowl or nap for
the uptake of the guiding pin for the thrust in advance.
15 Because the Wa11 of the cannula is omitted, if a sensor
bristle is used, the latter can be produced slightly
thicker, what is opportunely for the endowing with
chemicals for the influencing of current ard to the coat-
ing with ar outer protective layer against the diffussion of
chemicals into the body. (The skin,-thinned during its
raising eventually also with adhesive or squeezing
means, anyhow makes the remaining scqr¢s smaller).
Material, which can be reabsorbed, deserves the preference,
because a breaking off (of the sensor thread) can never-
25 more be totally excluded.The device for the introduction of the sensor bristle
can be also operated with a pressurized gas capsule. If
the gas pressure beam drives the sensor thread or brist-
le under the skin, the erd of the bristle must be en-
larged and ~rrested at a narrowness or. the end of thebearing sleeve. The current measurements can be perform-
ed between piled up stacking sheets outside of the suppor-
ting (or bearing) sleeve, after the sensor thread is
pulled out of the skin. (But this can be done also
inside the sleeves, if these are appropriately coated
with metal interior with contact derivation outwards).
- 23 -
~- 216~82
The threads which are endowed with the measuring layer
contact, after they are drawn back into the hose end,
therein witn a metallic layer over which the current con-
duction is performed through the appropriate wires or
leads to the measuring instrument. There are preferrably
two conducting are separated longitudinally by an insu-
lating zone, resp.twc insulating zones.
If the period of saturisation with tissue fluid in the
sensor thread can be held shortly, an additional squeez-
ing device (perhaps by means of two slides or platesunder the suction cup edge springy one against the
other) can he saved, when a suction cup is used.
In other cases, the p~essure or jet injection through a
nozzle occurs after the metabolism measurement, interrup-
ted by a renewed sucking-on of the skin.
But the dia~Jnosis with a sensor bristle can also be
transferred in a separate device housing. If pulver of a
solid drug is injected (perhaps in a crystalline shape),
pressurized gas replaces the "washing-out" or thinning
fluid for the pcint of entry into the injection channel.
But a measuring "cannula" can also be introduced under
the skin into the liquid lake over the m~scle skins or
fascia which consists of a drilled or shot-in capillary.
Such a capiLlary can be, inside or outside, endowed with
a measuring layer for metabolism measurements and it can
also serve for the injection of fluid (after the meas-
urement). But the capillary wall can also be punched
through (wi-h finest holes) and can serve to the
drainage of tissue fluid into a measuring zone in the
sleeve or capillary; additionally, of course, the capil-
lary of such a t~pe can also serve for the drug injec-
tion.
If a double-sided colour measured cylinder is used, the
measuring is achieved by laser scanning in bcth ends of
the cylinder ; on the side of the carrier suitably
through a kor of it. Instead of a laser beam, a light
beam can be used for the oFtical reflex measurement with
- 24 -
2164582
ancillary lens (also by use of light ccnducting fibres,
preferably with the method of optical soupling with
crossing ard punctually welded fibres).
Mzinly advantageous is the fixation of a minute colour-
changing sensor cylinder or. its tube-like carrier by
shoving its one end irto the end of the carrier tube
with a sealed connection (sticking or welding) of both
portions. A Pen-like instrument with such a "drawing-
pin sensor" needs not an optical skin ccntrol and has
a round end around the nozzle for the shot-in of the
sensor cylinder. Such a instrument can be pressed against
ary skin parties with elastic subcutaneous conditions.
- 25 -
2164~82
'_
Short description of the drawings
Fig.l is a schematical reprentation of a jet injector with
suction cup in longitudinal section in a scale of about
2 : l with pco~c~e lid for the suction cup inclusive the
nc,zzle.and with a dcuble injection cylinder and two sole-
ncids as pressure donators.
Fig.2 shows in longitudinal section in a scale about 3 : l
a ~et injector with suction cup with one dc,uble piston
cylinder ard water cleansing device, driven by spring
pc,wer, but indirectly by an electrical motor. Belo~- a val-
ve disk for fluid in cross section.
Fig.3 shows in a plan view in a scale 2 : l a valve (circ-
le) with ar ~lant lever. The latter is shifted between
two lock pins with a frame with slot along a bar.
Fig.4 shows in longitudinal section in natural size a
motor driven control gear for several operation. Above, to
the left a cross section of three gear wheels with shiftab-
le special housing.
2~ Fig.5 shows in a longitudinal section in a scale 2 : l
a sFecial type of a double piston cylinder with an
inner valve.
Fig.6 gives a jet injector with s~ction c~p in a longitu-
dinal section in naturale size. Over the tublet~8) is
drug filled into the anterior portion of a hc,se
end. The latt~r is emptied by a sGlenoid stroke or a term-
inal folded bcllows.
Fig.7 shows an injection cylinder with rectangularly de-
flected nczzle in relation to a suction cup, to the left
3G in a longitudinal, to right in cross section, both in
a ratural size.
Fig.8 gives a block diagram over an er.tire device as
therapeutic s~stem with oFtical skin ccnrol in a suction
cup ard wire-less connections between the electronic cc.n-
trol unit of the device and separated transmitter-emit-
ter pc,rtions, one of these on a kind of watch-bracelet.
- 26 -
216~82
'_
Fig.9 gives irl longitudinal section an overview over the
mcin device connection of the single pcrtions of the de-
vice, w~ereby the largest length is shortened about to 70
percent and the suction cup is respectively diminished.
Above in a detail with a special arrangement of the suppor-
ting cclumns for the strong pressure springs as pressure
donator. Above, to thè left, the lock pin for the auxilia-
ry slide for the release of the twc pressure donators
in cross section.
lQ Fig.lO shows the detail of a ccntrol gear for a jet injec-
tor in longitudinal section in a natural size. To the
right, the ro~ing up of the inner groove of the tube socket
(786, in the longitudinal section) is shown in a scale of
2 : l.
~5 Fig.ll shows the variant of a centrifugaly operated switch
in longitudinal section in a scale of 2 : l.
Fig.12 gives Ihe example of a lever thrust transfer to
t~o release functions with a trigger slag m~chanism
in a cross section and a scale of 3 : l.
Fig.13 shows details of a power transfer from a motor(not
shown) to operating functions(not shown) in a natural size
and a longitudinal section. Below, in a cross section and
a scale of 3 : l a ratched toothed wheel with a partial
breaking off to the left.
Fig.14 shows in a natural size, akove and in the middle in
a side view pcwer translating tcothed wheel of the device
according to Fig.9. Above the large toothed w~ieel for the
sliding screw, which tighten the strong pressure springs
as p~essure dcnators for the fluid ejection. Under that,
3Q in the middle a projection of pcwer transfer to the opera-
tion w~,eels (for example for metering) in different sec-
tion levels. To the right, a longitudinal section through
the detail of any toothed w~eel (from the side view)
are shown, cluite below an sideward (vertical) overview
to demonstrate the overlapping of the toothed wheels.
Fig.15 shows in longitudinal section on a scale of 2 : l
t~c exchangeable fluid ccntainer unit for water and thin-
- 27 -
21~4582
- ning f]uid. Below, to the left and tc the right, preferred
variations o~ the terminal pcrtions of the cGntainer as-
sembly from ;~1bove is illustrated.
Fig.16 gives below, to the left, a partial longitudinal
section through the pressure dcnator of the Fig.9, il-
lustrating the power transfer from the outern strong pres-
sure springs to each of the two injection c~linders.
Abcve, to the right, a cross sectional view is given to
demonstrate the joining together of the injection cylinders
into the common nc,zzle and the valve flaps behind the fluid
supply tubes (not shown) into these cylinders.
Below a single piston injection cylinder is shown (in the
middle) in the cross section with the mechanism for the
metered infl~lx of thinning fluid and the folded bellows
with a insulating fluid for the protection against pollu-
tion. A~cve the detail of two beveled wheels as alterna-
tive rotation transfer. Below, to the right a longitudinal
section throu;3h the t~o injection cylinders in the level
of the valve ~laps with the influx tubes for two drugs and
the thinning fluid (dashed drawn).
Fig.17 shows to the left in vertical or cross section
a detail of a pressure spring block or basket with a
space ccmpensation through a slot o~tside over the housing
wall during the release of the pressure donator.
Above, to the right, in a hcrizontal or longitudinal sec-
tion the function of bcth release slides(268) for the pres-
sure dc.nators are illustrated (c.p.Fig.9).
In the middle, above the possibility of a locking device
for a inner and outer pressure spring is explained during
3CI the spring release. Under that, the stage of pressure ccm-
pression is s~!own, all that in vertical or cross section.
To the left of the just described b]ocks or baskets,
a side view is given toward ore of the release slive with
the mechanism for an adjusting of the release interval
35 - between the two pressure donators. (Under the upper
release slide vertical section through the latter along dif-
ferent section lines).
- 28 -
2164~382
I_
B) Below, to the left, a schma~ic vertical or cross sec-
tion the variation of a pressure dc.nator with lever trans-
fer of spring tensioning by a wedge slide is shown.
C) Below, to the right a further variation of the pres-
sure dcnator bzsket is schematically shown with a shorten-
ing of the heighth by a clamF-like frame, to the right
pzrtially in different functional stages.
Fig.18 shows above, to the right, a further detail of the
pressure donator basket (c.p.Fig.9) in a cc~pressed (above)
ard relaxed (~elow) condition with the wedge slide for
for t~.e press~re tightening and a partial view of the
bag(257,c.p.Fig.21) for the s~ction production.
Abcve, to the left, a slant lattice net is illustrated for
the support of the p~essure springs (or dc.nators) in a ver-
plan view.In the middle, a hcrizontal or longitudinal section is
given through the lowest portion of the strong pressure
springs and a plan view toward the wedge slides and the
roller bearings for the lattice net on the former.
Below, to the left, the transversal section through the
functional divided wedge slides along the section line
A - B of the horizontal section.
Below, in the ~iddle, again a the mechanism for a delaying
of the release of the inner strong pressure spring is shown
on a vertical or cross section.
Below, to the right, a sketch is given of as pressure do-
nator release by an articulated support, which ccn be
tilded.
Fig.l9 describes, above in a vertical section, in the mid-
3C~ dle and below in vertical sections the cc,nfiguration ofa valve control for fluid and air, if a bag (Fig.21) is
used for the production of as s~ction for the skin fold
ard ar overpressure for the flashing out of fluids.
Fig.20 demonstrates in a kind of block diagram the
distribution o~ s~ction and overpressure from the bag
and the c~ange between the transport of thinning fluid or
water into the injection cylinders.
- 29 -
216~82
Fig.21 shows a vertical section throug a device according
to Fig.9 with the illustration of the bipartite bag fcr
the manual producktion of suction and overpressure between
a firm ccver sheet of the device ard a lid which is movable
acainst four pressure springs (from wich two are shown by
the section line near the side wall of the hcusing.
The locking and release device for the mentioned pressure
springs is s~ill demonstrated (Above to the right a
tlansversal section through the detail of the locking car-
riage over that). Above the detail of a connectionbetween the bag and the lid rep. ccver sheet of the device.
Fig.22 shows schematically three sGlenoids working against
three release f~nction: above for the auxiliary slide
for the pressure dc,nator release; in the mlddle, for the
expansion of the suction producing bag; below, for the re-
lease of the drug ard fluid ejection stroke.
To the left the detail of the end of an injection cylinder
with sectorally slotted blind for the opening of the noz-
zle be the wedge slant of the release slide.
Fig.23 gives a ~crinzontal section through a double working
solenoid Wit`l a thrust-rotation device for the the opera-
tion of any functions one after the other. Below a trans-
versal section along the section line A - B of the horizon-
tal section.Fig.24 shows an er.larged the electrical cur-
rent transfer o~-er a enlarged toothed wheel with sliding
contacts for the message to the electronic control unit.
Tc the left a transversal section is given, to the right a
hc,rizontal section.
Fig.25 shows, above in a vertical section, a suction cup
with a dcuble blind for the injection nczzle ard a
octical skin control device. Below a hc,rizontal section
through the details of the t~c blinds is given~enlarged).
Fig.26 shows an enlarged vertical section t~!rough a
suction cup (and a side view toward an injection c~linder)
with ar.other nozzle blind and an alternative for the opti-
cal skin con~rol. Below, to the left a partial hcrizontal
section is given, to the right a further enlarged detail
- 30 -
'_ 216~582
of the blind area.
Fig.27 shows ar er.larged vertical section through a suctior.
cup with ar annular blind w~ich raises, when the skin is
sucked up. The optical skin control device is mounted on
the blind, which is shown to the left in an elevated, to
the right (half) in the lowerd stage. Below a plan view to
the b~ind.
Fig.28 shows vertical section near an injection cylinder,
w~!ich is laterally installed, through a suction cup.
lC The optical skin control by a p~oto emitter ard sensor oc-
curs here or, a window, which is as an enlarged detail
represented below.
Fig.29 is a plan view to a control pannel of a device
according to Fig.9 and another devices. The adjusting
15 w~ieel are sectioned, through the breaking of near the
suction cup two injection c~linders. (The sleeves with
sensor threads an small folded bellows on a c~ain belongs
to a device a~ in the Fig.47-54). To the right a the vir-
tual image of a computer calculation with the programme
inputs for planned meals and work capacity in relation to
a metabolic e~fect by insulin.
Fi~.30 shows the enlarged detail f~ the program key
ar;d its arest~ng ledges according to a control panel as
decribed in Fig.29, akove in a vertical section, under that
in a hc,rizontal section. Below a side view in the direc-
t~on of the arrow.
Fig.31 gives a schematical side view of a device composi-
tion on a reduced scale. To the left the hcusing of a jet
injector in wire-less ccnection with a hc,using with the
*is shown electronic control unit ard the stacked on
additoninal recording eqipment in a wire connection with
t~le electrica~ charging device with recorder.
Fig.32 is ano~her functional block diagram of a device
cGmplex compr~sing an suction injector with skin squeezing
mechanism, a metabolism measuring device with changeable
sleeve with sensor thread (c.p.Fig.47-54) and the respecti-
ve electroniC control unit or p3rlogramme control-
2164~82
Fig.33 is a horizontal section through a jet injector forsingle drug cartriges using a suction c~p. Below, to
the left~ a pressurized gas stream pum~ for suction pro-
duction. Above, to the right, the detail with cartridges
for a pulver jet injection in serie. Below, tc the right,
a detail of the locking mechanism~for switching over to
rew injection, if a step *is shown syringe for multip-
le dosages is used; this is dc,ne in an enlarged vertical
section alon~ the carriage(9lO) with the hinged locking
t~ pulledbY the tow line(gl2)
Fig.34 shows spectacles for diagnosis by laser investiga-
tion of the anterior eye chamber. Abcve, the frontal view
against such spectacles on a face is demonstrated, in the
the longitudinal section of the right half of the device
on the level of the head-band with the singularity of
schematic f~ontal section through the left eye with photo
enitter and photo sensor ledges. Below, to the left, a
partial plan view under the longitudinal section in the
level of the blind visor, quite below a~ tc the right
cross sections through the respective adjusting wheel are
shown. To the right, a much enlarged eyeball with a
lateral ligh~ projection ard evaluation for the adjusting
of the light ledge for the metabolism measurement,
from wich below the left or.e is shown in further er.large-
ment, both i~ a frontal view.Fig.36 schematically shows the detail of two laying pres-
sure springs as pressure donators for twc injection cylin-
ders on a hc,rizontal or longitudinal section with operatio-
nal details.
Fig.36 shows, akove, in an enlarged detail on a horizontal
or l~ngitudinal section a two chamber injection cylinder,
which is e~!pt:ied by means of a piston driven by pressuriz-
ed gas.
Below, in a partial horizontal section, arother variation
of the tw~-plston-cylinder is shown and quite below, t
the right, a similar sc;lution.
Quite below, to the left, a solution is given, in which
the two piston are replaced by folded bellows.
- 32 -
~ 2164~82
-
Fig.37 gives an alternative and and cc.mpletion of a mecha-
nical ccntrol gear in a hc,rizontal section.
The enlarged wheel in cross section, below to the right,
belonges to the control of a fluid valve. In the middle a
variant of an iniection cylinder is showen with ar influx
control for thinning fluid (to the right in a vertical sec-
tion). To the left, in a hcrizontal section in the level
of the conne~tive strap, the mechanism of the swivelling
of the latter is shown over the folded bellows and away
from it. Below, to the left, a hc,se or tube brake is il-
lustrated, above in a~ enlarged horizontal, under that in
an enlarged vertical section. Below, to the right, a trans-
versal projection of the tccthed wheels is given. (The
latter was above shown in a tipping up).
Fig.38 shows very enlarged in a hcrizontal section a solu-
tion for a bolting of a cperation wheel (or function)
in a fixed position.
Fig.38 shows in a hcrizontal section a special ccntrol
gear with an additional intermediate gear for a speed
reduction.
Fig.39 shows a separated metering device driven by two
s~all solenoids, w~!ich works agaist wedges of a respective
wheel (shown in a rolling up), to transform the thust mo-
tion in a rotation for thc metering screw. (To the left
through an additional intermediate gear for larger a~ounts
of drugs).
Fig.41 shows in an enlargeded and schematic hc,rizontal sec-
tion with a pressure spring and a lever t~ansfer toward
the pressore donator.
Fig.42 shows very enlarged a piece of a tape for the
data registering with printed o~,t input and measured date
and other e~sential calculatated data.
Fig.43 shows a table for a schematic calculation of ne-
cessary insulin quantities by a computer relating to
input data (Information page)
Fig.44 supp'ements the Fig.43 with input data.
Fig.45 supplements the Fig.43 ar~d 44 by calculation data.
- 33 -
~, 2l6q~82
- Fig.46 gives a principle set up of an optical skin ccntrol
using the reflex photometry.
With Fig.47 begins the demcnstration of an supplementing
device for providing of a jet injector with metabolism
measured values, especially with tissue sugar values.
This is done on a somewhat reduced scale in a rolling up
on a hc,rizontal or longitudinal sectional view. A~cve,
tc the left the top of a sensor bristle bearing sleeve at
a naturale size. Below, to the left, an enlarged vertical
or cross section for a locking device against the retreat
of the br-istle, laterally with a partial side view.
Fig.48 is a schematic vertical or cross section through
the device of Fig.47. Below, a hc.rizontal or longitudinal
section is shown through the detail of the pressure dona-
tcr support.
Fig.49 shows in ar, enlarged detail two functional stage
of a special oush-rotation mechanism fcr device according
tc Fig.48 on a horizontal or longitudinal section.
Below, to the left, the four switching positions(A-D) are
schematically detailled projected-in a side view.
Fig.50 schematically illustrates a much erlarged sensor
capillary and its o~eration in a hcrizontal or longitudi-
nal section by hand activated syringes.
Fig.51 gives much enlarged a special sleeve for a sensor
bristle ar~d an additional device for the injecting of it
in a hc,rizontal or longitudinal section. Above, to the
left, a shortened detail of the sleeve in the stage of
being broken c~ff. Quite to the left, a vertical or cross
section is shown through this sleeve.
Fig.52 shows on similar conditions as Fig.50 the variation
of a jet injection of the bristle by pressurized
ga~. Above in a cross section stacking sheets~for the elec-
trical ccntact with the bristle in two stages. *are shown
Fig.52 shows ~he variation for the introduction of the
bristle (enlarged details above to the right) as a drill.
Fig.54 to the left a ~ristle device a a carrier for a s~;all
measuring cylinder, to the right, enlarged the reflex opti-
c~l e~-aluation. Fig.55 gives a auxiliary device for urin
sampling, Fig.56 an alarm device against low nightly sugar.
- 34 -
21~4~2
Detailed description of drawings - '
Figure 1 is a schematic representation of an injector in
the longitudinal section at a scale about of 2: 1 (where-
by the nozzle and drug channels are further er.larged). The
closing stopper(2) is shoved into the suction cup(l). The
area of the nozzle(3) is closed by the china socket with
the incandesce~lt wire~4) by means of the sealing ring(5).
The leads(6), ~ymbolized with dashed lines, lead to ar
electric plug and then to the current transformer (not
shown). The tissue friendly fluid is also filled into a
step syringe(7' as customary in the trades and can be
metered by a pressure button (nct shown). The screw cap
for the cannula of the step syringe is connected with the
cylinder(9) under the piston(10) through the rigid tublet
(8). The valve flap(ll) is demonstrated during the filling
up of the cylinder to make it more visible.
The connecting hose(l2) over the back valve(l3) in the
wall of the suction cup is diverted to the folded bellows
2û (14), again for a better representation, The latter
is fastened on the hcusing(l6) with the bottom sheet(l5);
the head sheet(l7) of the folded bellows
is enlarged by the solenoid(l8) working by drawing and
serving the sucking on of the skin. The anchor or rod
(19) of the belonging solenoid is shown as pressure donator
for the piston in the drug cylinder. The pressure spring
(20) symbolizes the backward motion of the anchor or rod.
The hammer(21) for the plunger of the piston(10) is bent,
because the pertaining solenoid lays covered as well as
that of the folded bellows. The dashed lines(22) toward
the plug for the cc,ntrol device or unit (nct shown)
represent all wires of the solenoids.
Figure 2 shows a injection device in a schematically
longitudinal s~ction at a scale about of 3 : 1 .
The inner cylinder(24) with the longitudinal millings on
its end is shoved into the outer cylinder(23) with the
-- 35 --
2164~82
nc.zzle(3). The lower piston with the annular edge mi.lling
(25) above glides in the inner cylinder around the central
plunger with the erd ledge(26, cross section bellow).
The plunger can not be drawn out of the central bore(27)
of the uE~per piston in such a way, but it can be shoved
i~. From both rotation (or disk) valves(28, see Fig.3)
orly this is shown in the uF~per piston, which leads over
the hose(29) to the folded bellows with clean water.
A branch of the w~ter ccnducting hc,se flows together with
the c~annel for the drug, over the rotation or disk valve
into the anterior cylinder space. The folded bellows tc
the right with the tissue friendly fluid inside of the
supply cylinder(31) is correspondingly fitted with hoses
and valves. Pressurized gas bclster(31) with compressed
CO2 promote the e~ptying of the folded bellows. The
strong pressure spring(32) serves as pressure donator
for the upper piston, which is supported upwardly
against th~ rcof of the housing(l6) and downwardly to the
piston bowl, shiftable in the housing and bearing cen-
trally the pct(33) which is cu~ out to the left.The belt(35), which is fastened in the centre of the
hc,using roof, is led thrcugh a central bcre in the pi.ston
bowl and serves for the stabilization (or guiding stabi-
lization) during the motion of the latter. The guiding
pin(37), which pro~ectes from the piston bcwl, prevents
the axis rotation in the housing slot(36). The piston
bowl is lifted for the compression of the strong pres-
sure spring by means of the screw(38), which is guided
in the screw of the cross stay(39).
A toothed wheel is fastened on the lower end of the
screw, in which the wheel is driven by the pinion(40).
The latter is shiftable along to the square operation
shaft and s held into mesh with the toothed wheel by a
kind cf g~~ding disks.
After the release bolt(41) is turned through the
pinion(42), which works to its toothed wheel, under the
2164582
edge of the piston bcwl, the screw is now turned downwards
again in its exit position, to allow the relaxation of the
strong p~essure spring(32).
After the retreat of the release bclt(41), the cut out pct
(33) strokes tc the upper piston plunger(34), the piston
of which is driven dc.wnwards and herewith toward the noz-
zle. The pcwer transfer to the lower piston is achieved
o~-er the fluid (tissue friendly or water) between bcth
pistons. When the fluid between the lower piston and the
nozzle is expelled to a greater extent, the fluid from
the inter-piston space can be emptied through the ann~lar
edge or marginal milling(25) on the upper piston and late-
rally through the lower longitudinal millings on the
inner cylinder(24) over the the chamber before the upper
piston and the nozzle without an interruption of the beam.
After each injection, a maximum chamber respective cylin-
der filling is effected after a ccrresponding opening pc-
sition of the disk-shaped three-way ccck over the flexible
shaft(43), so as the clean water is filled, near the noz-
zle, into the lower cylinder by tne influence of the pres-
surized gas bolster(31) and bcth pistons are lifted. After
the three-way ccck is closed, the disk valve(28) in the
upper piston is opened and the space between the pistons
is filled up. (The piston strokes are additionally actively
lifted in the derivated application examples). The moment
of release of the syringe emptying by the screw bolt(41)
can be determined by the user. During the preparation for
injection, the chamber behind the nozzle is filled up, whi-
le it is closed by a lid or closing stopper(see 2,Fig.l)
from the folded bellows with the tissue friendly fluid (per-
haps~physiok~ical salt sclution), first, urtil the lower
chamber or. th~e inner cylinder is closed by the lower piston,
perhaps relation to the the illustrated position. The drug
is transported out of the cartridge through the cannulas or
rigid tublets(8) into the space behind the nozzle by the
rctation of the micrometer screw(44). The inter-piston
chamber is filled up in an analogue manrer as the clean
- 37 -
21G~582
water (or drug) after the opening of the disk valve (45,below in the cross section). The sucking of the skin
over the suction hose(46) preceeds each injection. (In
this case by a larger injection syringe, not shown). As
soon as the skin knob touches the three contacts lateral
to the nozzle exit -one of these is shown in Fig.8- the
operation of the release bolt(41) is activated.
The mechanical mction transfer -as it perhaps occurs bet-
ween the flexible shaft and the toothed wheel(47) for the
drug meterin~ and the cross shaft in gear m~sh with the
former- is omitted and a box(48) for the electric mc,tor
and the ccntrol gear (which are minimally calculated)
is drawn in. From the numberous electric ccntrol contacts,
orly the counter pin(49) and the correlated cc.ntact spring
t50) on the hcusing are indicated, which ccntrol the drug
metering.
Figure 3 shows ir a plan view on a scale of 2 : 1 a valve
(circle) with ar slant lever(~ine). The latter is shifted
*(313) betwen two lock pins(314,315) with a frame(316)
with a slot along the bar. (The Fig. demonstrates a
possibility of fluid cGntrol in a device according to
Fig.l and 2).
Figure 4 schematically shows on natural size the control
gear of the invention according to Fig.2. A free change
between the functions ard functional periods have been pro-
vided in ccmparison with the solution in DE P 59 25 940.4.
The task was solved by operating the work driver for the
cc,r.trol pinion between the different operational w~ieels by
a chaine whiich acts on occasion of a pcle c~ange of the
mc,tor, shifting against the wcrking phase of the pinion
axis. The driving direction is only counteracting on the
pinion axis(~l) and the mc,tor axis(53) in each case.
The rotation direction of axis and chain is respectively
inverted or. 'he final phase of the pinion shifting similar
as by a tape of a typewriter. The ccupling for the change
in the switching pcsition is transferred into the axis.
The reduction of the rotation speed occurs from the motor
- 38 -
2164~82
axis(53) through the translation toothed wheels(54). Thecpupling is effected for the switching over of the motion
direction between the main operation wheel(55) and the
large toothed wheel(56) through the distance ccupled pa-
rallelly shiftable pair of toothed wheels(57) or -for an
inversion of motion- over the derivation toothed wheel
triade(58).
The latter is demonstrated in its special housing(59),
which is shown above in a cross section. The hatching
might replace the representation in the depth planes (or
cutting). The diagonally hatched wheel halfs show the pla-
ne onto mesh which is destinated for the drive of the lar-
ge wneel(56). The transverse hatched half indicates a mid-
dle tocthed w~:eel which reaches with its perpendicularly
hatched half the toothed w;:eel which is destinated to mesh
with the main operation wheel. The special hc,using is
slided along tc the sqare bar(6C;).
The switching hook(61, in dash-and-dot lines) is taken
with with its fork ends or. the final phase of the motio
of the cc,ntr~l pinion. The motor is driven staccato and
e~7entually charged with c~rrent under pole changing until
control contacts (not shown) record the f~711 meshing of
the teeth.
The ratchet -coothed wl-.eel are simplificated by the hookes
with axle fastening; the belonging ring of ratchet teeth
was only indicated. One thoothed wheel is driven from each
of both switching aggregates, which bcth mc,ves the trans-
pcrt wheels of the control cnain(52) by a cross drive with
toothed (or beveled) wheels. A counter acting ratchet and
pawl mechanism, but also here, provides the necessary tun-
ing. The axis of the ccnrol pinion has a cross pin inside
of the large toothed wheel(56) which is cushioned against
both sides and shiftably by lateral pressure influence.
The cross pin meshes with a projecting driver edge inside
of the bushing bore cf the large toothed wheel. The cross-
pin rotates freely, after the axis is laterally shifted,
because the large toothed wheel is secured against lateral
- 39 -
216~8
~,
- shifting by a fork(65). In such a WG'Y a coupling effect
occurs. The row of the operational wheels is o~!itted, to
which the control pinion meshes, to one after other; just
as little the common axis parallel to the axis(51) of
the control pinion is nc,t shown.
Figure 5 shows a cylinder with double piston for the in-
jection similar to that in Fig.2 in the longitudinal sec-
tion at a scale about of 1 : 2 (with an exaggeration of
the nozzle diameter). The cannulas or rigid tublets(8)
terminate from both step syringes (with drug an body fri-
endly fluid) near the nozzle in the c~-linder(67). The
orifice into the cylinder chamber is closed by the valve
flap(ll) each to the other. Tissue friendly fluid is also
filled into the inter-piston space through the upper pi-
ston over a hose and the disk valve(28). The valve disk
(68), which closes the central bcre of the lower piston,
is closed by the tension spring(69), that is, pulled near
the piston. The valve rod can not be drawn out of the in-
ncr bcre(70) in the upper piston (as in Fig.2). The valvedisk or cone(68) shows below an insected star-shaped~pro-
file for the fluid passage. The lower chamber with the-~~~
drug is emptied, first, if the upper piston plunger is
stroked with pressure by the pressure donator. The plunger
over the valve disk(68) on the end of the inner bore(70)
finds then resistance or! the end of the inner bcre(70) of
the upper pi,ton and the valve disk lets the fluid pas-
sage central 'L y free.
Figure 6 shows a solution without valve mechanism between
the drug a~d the bcdy friendly fluid for the overpressure
injection in an about naturale size in the longitudinal
section.
Folded bellows and hose end(71) are replaceable pcrtions
which are filled with body pleaceable fluid. After a cover
cap on the hose end(nct shown), the latter was introduced
in the screwing on tube(72). A small lateral opening in
- 4C -
216~82
the hc,se wa~ made coinciding with the drug admitting can-
nula, while following to a marking. The cap(73) is fasten-
ed or the screwing-cn tube by means of a bayonet clamp.
The tension sheet(75) is in an adhesive ccnnection with
the adjusting screw(74) The latter is screwed back relat-
ing to the dosage, while hollow space, produced by the
metering, is filled up from the step syringe which is part-
ially shown. The piezzoelectric sclenoid as pressure dcna-
tor is approached along the slotted ledge(77) to the cap
(73) and then loaded with current. The folded bellows is
e~ptied through the nc,zzle by the three pressure pins(78),
the drug first.
Figure 7 shows,in natural size the preferred position
of the nc,zzle, to the left, in longitudinal section and to
the right in cross section. This nozzle(3) lies on
the end of the cylinder and laterally in it, so that more
space is disposable for the pressure dc,nator which is also
laterally positioned, in this case a strong p~essure
spring(32), in a pocket portable~and flat shaped housing.
Figure 8 is a kind of flow chart of an injection device
in its totality as a therapeutic system.
The injector, which is mainly symbolized by the suction
cup(l) is fitted with an optical cc,ntrol device for the
aptitude of ;~he puncture area tc exclud pathological skin
areas. The l-ght beam which is projected from a light scur-
ce(LED) through fibre bundles is subdivided into t~o projec-
tion areas and two measuring areas. The one of beam(78)
projects against the puncture area, the second(79) to an
adjacent area. The comparison of bcth brightness values -
eventually compared with measured values of the proceeding
use- speak for the aptitude of the skin if they are near-
ly corresponding. The pressure donator(81) is activated
over the control part or unit(80). The metering of the
drug was taken before with the keys of the ccntrol unit
under display control. Pin and cc,ntact spring(49,50)
- 41 -
2164~82
transmit th~ related ccntrol values with the rotation ofthe mircrometer screw. Dosages can be input as well from
a ~ire-less transmission part or unit as such or other da-
ta can be tLansmitted from the injector to the transmis-
sion-receiver part or unit(83). From there or or the de-
vice, glucose measured values can also be input, in such a
~anner in w~;ich a programmed ccrrrection of the drug amounts,
which
should be ir.jected, is pcssible.
10 The drug dosages ard other dates can be time proportional-
ly documented mainly by the occasion of the battery charg-
ing on the m2ins.
/The optical skin control is suitably repeated after
the injection. In case the fluid beam has not pene-
15 trated the s~in or not completely, the measured lightbrightness values differ very from those before the injec-
tiuon caused by fluid reflexes. This lack is reported and
registers should the occasion arise. If this lack re-
peately occurs, the injector is blocked in its function by
20 means of the control part or unit.
The arrangement of the three cc,ntacts for the "earth cir-
cuitry" with the skin is shown in Fig.7.
Figure 9 gives in the longitudinal section an overview
over the principal device cc.nnection of the singular por-
25 tions of the invention, whereby the greatest length isshortened to 70 percent and thereby the suction cup is
also accordingly diminished. Above, a correspondingly
scaled detail is s~own with the representation of the
screw(l25,c.p.Fig.13) for the thrust of the plunger in-
30 side of the drug or insulin c~rtridge(ll3). Just aboveto the right, the detail of the stop krob(270) of the re-
lease stop is still shown in the natural size. The latter
is operated by a tow-line from the ccntrol gear (see
Fig.12), to release the mc,vement of the release slide
35 (268,below) asainst the pressure spring(269).
T~le latter ii displaced by influence of the pressure
spring(260) nd becomes free, shortly one after the
- 42 -
216458~
other, the locking blocks(847,848) for the pressure donator or
springs(261,262) of the cylinder(9) for the injection of drug-
thinner mixture and of the cylinder for the injection of the
thinner(c.p.Fig.17).
5 The release slide and the locking blocks are daubly installed
symmetrically as any other functional pcrtions.
B~t the same is valid for the sliding screw(352), which is
turned out of the screw sleeve(850) by the strong toothed
wheel on the screw sleeve. A wedge slide(850) is shoved
10 under the pressure danators on the roller rail(852) by means
of the slide carriage(851), so that the pressure donator
springs are lifted and tiahtened(c.p.Fio,.17,10). The vigor-
ously constructed control gear(279,c.p.Fig.14 in the frontal
section) becomes its motion mcment over the smaller toothed
15 wheel(853). The latter is driven from the pinion of the con-
trol aear(c.p.Fig.10) over the tIanslation toothed wheels(54)
from the motor axis(53). The switching over from the func-
tional block A to the functional block B takes place over
the shifting of the switching bar(789) at the last phase
20 without a further lifting function of the wedge slides; that
serves to the purpose to drive the screw(121) for the in-
sulin metering and additional auxiliary functions (c.p.Fig.
12,13). The already described release functions fall in the
initial phase of the functional block A.
25 Also in the detail above, the support column(854) is arrang-
ed outside of the pressure donators and serves
with tow analoguous columns to take up the spring pressure
inside of a special frame(c.p.855,Fig.9 below). The connec-
tion strap(856, strong lined) serves to the equal power
30 transfer from the outer pressure donator(261) to the injec-
tion cylinder(9). Two of these three connection straps(266,
267 below) lead, under the iust described connection straps,
from the screws for the limitation of the metering plunger
or piston movement.
35 The supplying of t;he syringe (or iniection) cylinder with
drug or thinner -after each injection also with weter for
_ 43 -
,i 2164~82
cleansing- ensues from the folded bellows for thinner and water
(90,190), which are skoved into cylinder, which again on
their part are finally connected with an uptake cylinder(858)
c.p.Fig.7). The supply of the folded bellows with the over
5pressure and the suction production are performed from a bag
(263) when the lid(260,Fig.13) is lowered. The four tube
socket(258) for the uptake of the pressure springs(259) are
drawn in. An oval shape of the suction cup (c.p.the detail
above) is chosen a~ variation.
lC The battery(155) and the electronic control unit(80) are
still positioned inside the bcx-like housing whereby the
wires and hcse ccnnections are omitted for lucidity. Only the
housing ring(202) is described from the valve for the control
of pressurized air and fluids. Ccnstruction and function are
15 described more exactly in Fig.11 and 12.
Figure 10 shows in natural size, the longitudinal section
of another solution for the switching between functional
blockes. Because in this case a switching happens in
20 three different operation wheels, a siiding switch is
not necessary for the spooling back of the metering
screws. The metering screws are positioned for forward
and back motion for functional block B or C, respectiv-
ely. The free turning toothed wheel with the leaf spring
25 (785) may approach to the pinion(351) through the switch-
ing bar(789) -on the final stage of the sliding function
of the block A(c.p.Fig.13)- by tightening the pressure
spring(495). The forementioned toothed wheel lies in
front of the pinion(351) on the mctor axle of ccurse,
30 in close connexion with the gear transmission or reduc-
tion gear. This g~ar drives with sliding seal on the
axis the oFerating gear wheel(293) for the block A
Because the cam(733) moves into related recess, the pre-
ceeding toothed wheel is rotated by the pinion. This
drives the operation gear(293) when the pinion is shoved
to the right toward the operation gear(790) for the
- 44 -
,
2164582
switching or functional block B. The cross pin(788) ofthe motor axis is maved and mounted in the (also rotat-
ing) flanged sGcket(786), inside of the coiled groove
(787) with three recesses correspanding to the switch
position. Each recess offers support, first, against
shifting to the right of the mator axis and in the oppo-
site direction after the shifting motion is released.
The last backward movement to the left is achieved by
the tension spring(784) between the cross stay(791) and
the hausing wall. As shown in the detail to the left at
a scale of about 3 : 1, the cross pin is restored to a
position corresponding to the functional block A after
the functional stage B.
The pressure spring(495) is relaxed by releasing the
pressure on the switching bar(789). The leaf spring(785)
in the recess of the toothed wheel creates a division of
the forementioned toothed wheels, so that the nap(783)
leaves the pinion. Halding plates(124) can secure connec-
tion to further toothed wheels for the transfer of opera-
tional functio~s. The sliding sleeve inside of the motoraxis is nc,t drawn.
For variation, the flanged socket(789) can be secured
against rotation. The mc,tor power is then transferred to
the pinion from a parallel axis through a gear wheel
which is lead with the pinion in a holding plate connec-
tion. Thus the pinion(351) like the operating wheel
turns freely around the axis.
Figure 11 reproduces, in a longitudinal section at a scale
3C~ of about 2 : 1, the detail of a centrifugally operated
switch as described already in Fig.9. The ratched gear
wheels in pairs(703,702) and (707,706) were shifted to the
left on the sl,~ding switch(717;c.p.Fig.29); thus the me-
tering screws ~an be spooled back this way. The direction
of the motor chooses one of the two. Over a toothed wheel
to the roll(69~) the drive runs from the oear transmis-
sion wheels(54` after the mc,tor over a toothed wheel to
_ 45 -
~ 2164~8~
the roll(699). The slide(606) which is formed as pin de-
termines the choice of the functional block, as the case
may be either in the worm guidance (shaft) of the inner
axle(715) -as drawn-
or in the worm groove of the outercylinder(699).
The slide(606) qontains a portion which is permanently mcg-
nctic and is he~d in the roll in a more centripedal pc,si-
tion by permanent magnets. With centrifugal pcwer it is
pushed with th0 motor rotating speedily outward into the
worm groove guictance of the outer cylinder, in order to
rotate the outer cylinder when the end of groove is reach-
ed. (During the continuation of the rotation direction,
the speed of rotation no longer makes a difference for
switching function). The switching situation shown would
transfer, with rotations against the worm groove, the pow-
er over the inner axle(715) and the toothed wheels and the
free-turning axle sleeve(781) over the switching chain(52)
to the functional block A for the cannula retreat.
If the direction of the motor is changed, it would solely
alter the direction speed for switching chain slightly.
(The motor retardation can be reached through electrical
resistance or through an interrupted staccato current sup-
ply). With a more speedy run, a pcwer transmission is ach-
ieved through the outer cylinder and the wider gear wheelto the gear wheel(701). The c,lear wheel rotates its axis
and, through the axle sleeve(781), the ratchet wheel
(703). The bevel gear wheel(704) is driven over the gear
wheel(782) and another gear wheel rotating on the same
axle. Thus the bevel gear(709) is driven on the cross axis
toward the corresponding mctering screw (functional stage
B). This happens through a border toothing of the bevel
gear(704). The r~tchet wheel(702) goes out of function be-
cause its cam(783) has left its counterpart on the turn-
ing bevel gear on its axle. The mc,tor turning in oppo-
site direction is transferred by the ratchet wheel(707)
in mesh with the toothed wheel(708) over the tube seg-
- 46 -
~ 2164~82
ment to the other metering screw. (The thread directionof the metering screws are suitably coordinated against
each other in s-;ch a way nc, switching over is necessary
on the centrifugally operated switch for changes of meter-
ing). With the manual operation of the sliding switch(717),the ratchet wheel(706) is pushed to the left over an annnu-
lar groove into the axle and has thereby lost its axle mesh.
The symmetric between the periphery of the wheel and the
lG device wall expanded tension spring(796) can produce a
kind of release point, that is, a delay between the relea-
se functions which can be used for the optical skin control.
The leaf spring(797) on a cam of the driving bolt(798) in
a bore of the slide presses the release bolt against the
tooting of the wheel segment. The latter shows there a
locking effect for the influence of the bolt in one direc-
tion; the backward movement is brought about then over
power mc,ments of another mechanism (not reffe,~ed to here)
which is eventually classed with another functional
2G block.
Figure 13 shows in about natural size, in a longitu-
dinal section, the detail of a power transfer to a func-
tional block from a mc,tor (not drawn) and an operation
wheel. The operation wheel(792) chosen is specially large
and lies under the pinion(80û) which is driven from the
former. In the demonstrated functional stage, the lateral
naps(783) of the pinion approache likewise naps of the
toothed wheel(802) firmly ccnnected to the screw(8G1)
about which the pinion can rotate. This is done to rotate
said toothed wheel(802) ard therewith the screw.
Hclding plates(124) prevent the toothed wheel(8û ) -which
without transfer function can also be a disk- from
shifting laterally. The toothed wheel(803), is like a
toothed wheel(804), connected with the screw(801) but able
to rc,tate about that. The screwed sleeve(8C4), in which
- 47 -
~ 216~582
the screw(805) projects, is firmly connected with the
toothed wheel(803), The plunger for the thrust of the pis-
ton in the drug cartridge can be moved directly over the
5 bar(806) which is connected with the screw(8û5).
Opposite working ratchet wheels(702,703) can overtake the
transfer functions for the drive of a metering screw(c.p.
Fig.9 in connection with Fig.14) in tooth meshing with
the toothed wheels(803,801) for example over flexible
10 shaft5.
(The coupling of the latter t~o with the metering screw is
then effected over separated toothed wheels which lay on a
common toothed wheel around the metering screw radially
offset to their common drive axis as well as the ratchet
wheels(707,706). If the pinion(800) is shifted on its
screw(801) totally to the right, after the mc,tor has chang-
ed its running direction, the naps(792) of the screw(801)
mesh with one such on the toothed wheel(803). The latter
and therewith the screwed sleeve(804) is rotated now. The
2C!screw(805) is now shifted to the right with its rota-
tion preventing linkage(808). The~thrust motion of the
pinion(802) is transferred over the bifurcated rod(809)
of the switching bar(789) while its cross pin(811) en-
geges the corrugated leaf spring(810). The latter, with
2sits bar in the pierced socket .is therefore shiftable and
jointwise connected with the switching bar(789) which hes
n;~ng axle stationary on the housing. The pick-off of an
additional ratchet wheel rotation is to prevent the
transfer of mc,tion functions in the position of the pinion
30(8CO) meshed ~ith the toothed wheel(802). The function,
which in any ~ase, is secured over the corrugate profil of
the thread wheel(814) pressed or, by a pressure spring
against a rotation locking of the former, is coupled off
b~ pulling of the nap disks(815,816) asunder. The nap disk
35(815, or the nap wheel) is in axle mesh laterally shiftab-
le to the ratchet wheel. The nap disk(816) turns free or
the axis and stands in axis ccntact with the wheel with
- 4~ -
~ 2164S82
corrugated profil preceeding the toothed wheel(814) overthe flexible shaft. (The corrugated profil is drawn
again below).
Figure 14 gives, above, a frontal sectional view imme-
diately b~hind the housing wall near the motor of device
according to Fig.9. The large toothed wheel translation
(279) which is driven from the motor through the small
toothed wheel(853) causes the analogue sliding screw to
the left, in comparison with this to the left, having to
be fitted with a counter running thread for this space
distribution.
Urder that, to the left in the middle, and to the right
of this in a longitudinal section, but below in a cross
SE ction, a detail is reproduced of the power transfer
from the motor axis(51) through the operation wheels(790,
703;707,706) ard other propulsion elements.
Figure 15 shows in the longitudinal section in a scale
of 2 : 1 a container with folded bellows for thinner
(90) and water(190) as a preferred type. The package
cylinder has a partition(196,Fig. ) which can b~ shov-
ed with its edge socket against the sealing ring(381)
of the lower partion(382) of the container housing.
The edge socket is pressed firmly by the pressure of
the middle cylinder(393), which again is tightened by
the sEaling ring(391) against the lid cap(390) which is
tightening pressed on by means of the bayonet catch(388).
; The thinner afflux occurs through a hose with the can-
nula(385) on the end of the bottom lid(383), which is
tightened against the lower partion(382) by the sealing
ring(384). The cannula(385) is sealed toward the folded
bellows by the elastic plug(394) which is suitably a
portion of the folded bellows. The package cylinder(395,
detail bellows to the left) for the uptake of the folded
bellows (90,190) has around the plug(394) a gap or near
- 49 -
216A~82
the plug a hole(396) for the gas pressure exchange.
The lid cap is screwed on by means of the catch hinge
(392) as customary in the trade, which deflects out
of its longitudinal axis about 90 degrees b~ spring
power ard bends laterally.
If the socket(397) with outer thread is added around a
central recess as shown in a detail below to the right,
the annular plate(398) can be stored in this recess on
the annular seal(399). The inner edge of the lid ring
(400) presses against the sealing ring(401) on the an-
nular plate. For this inner thread of the lid ring
meshes with the outer thread on the socket(397). The
sealing rings(384 391) can be omitted in this suitable
ccnstruction. The bottom lid(383) and the lower pcrtion
(382) are then melted into one single portion as
is also done with the middle cylinder(893) and the lid
cap(390).
The gas apply to the folded bellows occurs separately
through the gas afflux sockets(387,388), the fluid is
applied through the cannulas.
The lid cap(390) is screwed off by means of the catch
hinge(392) for the exchange of the package cylinder
halves. A calibration difference of the inner cross
section (perhaps hexogonal profile in the lower portion
with adaptation also of the package cylinder halves)
serves to avoid an incorrect supply of thinning fluid
and water to the derivation hoses. The adhesive cover
foil(404) which protects the hc,le(396) and the plug
(394) against pollution is to drawn up before use.
If, as shown in the detail below to the right, a socket
(397) with outern thread is set up at the bottom lid
(383) t-len the annular plate(398) can be left in the
annular seal(399) of this depression. The inner edge of
the lid ring(400) presses against the sealing ring(401)
on the annular plate. An inner thread of the lid ring
meshes for this with the outer thread of the socket
(397). The sealing rings(384,391) can be omitted for
- 50 -
~ 216~582
this suitable construction. Bottom lid(383) and lower
portion(382) are then fused to one single partion, as
with the m~ddle cylinder(8g3) and the lid cap(390).
The gas supply to the folded bellows occurs separa-
tely through the gas admission sockets(387,388), the
fluid supply through the cannulas.
For an exchange of the package cylinder, the lid cap
(390) is screwed off b~ means of the catch hinge(392)
and the drawn out package cylinder, which has left the
cannula, is pushed away from the cannula(404). The new
pzckage cylinder is pushed into the lower portion(382).
A sudden calibre charge between bath half of the pack-
age cylinder or suitable differences of the inner diame-
ter (perhaps hexonal profil in the ]ower portion with
adaption also of the halfs of the package cylinder)
serve to avoid a false supply of thinning fluid ard
water into the derivation hoses.
Before use, one pulls off the adhesive or sticking pro-
tective foil(4C2), which protec~s the hcle(396) and
plug(394) against pollution.
Figure 16 consists of details which explain the ccm-
; position of the injection cylinder. The half of the
horizontal section demonstrates the positional rela-
tions in the closing area of the injection cylinder(9)
with the connecting stap(267) toward the screw sleeve
(857). In the variation, which is shown in the vertical
section below of the horizontal section, the screw
sleeve does nc,t proiect up to the roof of the injection
cylinder, but it is firmly ccnnected with the latter.
The screw(~97) is lifted and depressed b~ the rotation
of the flexible shaft(863) and therewith the piston
(10) which is connected through a rod with the plate
against which the folded bellows or the sealing mem-
brane is screwed together air-tight.
- 51 -
2164~82
- Water or another fluid is filled-in between the folded
bellows and the piston, which ccmpensates the volume
displacement in co]laboration with the folds of the
folded bellows, that is, if the piston is moved and
this for a protection of the space under the piston
against pollution and entrance of air. (A rinsin~
socket for temporary cleansing the inside of the fol-
ded bellows is omitted). The connective strap(267)
mcshes with the thread of the screw(357). As the lower
lû end of the cylinder(9), the opened valve(11) is drawn
in with the supply hose for water(29) below it.
The connective strap(856) serves the power transmis-
sion to the pressure spring(261, detailed in the
horizontal section above), for the expulsion of wa-
ter or the drug injection. The crossed beveled gear
wheels, meshing with one another, indicate that the
flexible shaft(863) can also be driven-on otherwise.
The flap valve(11), which can be also replaced by the
customary valve ball, is skown iust below in detail in
the horizontal section; for the opening of this, the
rigid tublet(8) from the drug cartridge and a supply
hose for water(29), in both cases lead in this direc-
tion to meet there.
The detail just above to the right is a vertical sec-
tion along the section line of the horizontal section
detail tr) the left under that. It shows the joining
together of the drug exit out of both adjacent injec-
tion cylinders(9,67) in the injection trow(865), the
nozzle of which is directed into the suction cup (not
shown)-
Figure 17 serves, with series A to C, the schema-
tical representation of solutions for the blocking of
the pressure springs(261,262) as pressure donators for
the injection.
In serie A, the detail around and inside of the pressu-
- 52 -
-
~ 21~
re springs(261,262) is rectangularly rotated against
the representation in Fig.1 and a sleeve is shiftable
along the support cc,lumn(854). But the stop bolt
(104), here in peirs, reaches a nctch in a support co-
lumn through the bore of a sleeve for arresting.
The support column is clearly or both vertical sections,
in the middle, from which the upper or.e corresponds to
t~e sta4~ with detented springs, but the lower stage
to that is tightened. (The tension takes place by
shifting under one or any thightened springs clearly
visible in Fig.10). To the left of the fore-
mentioned images, ore of the release slides
(268), which exist in a peir, is shown. The small sli-
de(273) or this can be adjusted with its working slant
through a screw of the control gear(c.p.Fig.5 above to
the right). The hatched rectangle on the release slide
represents the respective ccntact with the edge pro-
jection on the edge (also hatched) of the bridge(866)
toward the sleeve with the slidable cross bolt(35).
When the edge projection is de~ressed during the moving
past of the release slide, the bridge(8~6) is also low-
ered and the bolt releases the depression of the in-
ner bridge arm(867).
The inner ?ressure spring(262) is propped to the lat-
ter. But the bolt(35) can leave the annular natch of
the inner .support column(868) by making a way in the
support cclumn of the outern bridge(866). (The functio-
nal stages are better read from the representation in
;h~- m~ddle below toward the middle above). The profile
of the release slide is evident from the row of hatch-
ed cross sections alono the respective section lines.
To the right on the pressure spring baskets, the stop
bolt(104) for the outer pressure spring(261) is marked
in. The corresponding distance of the release slide has
a wedge formed profiled narrowness (c.p.also the small
detail above) for the blocking of the bolt.
- 53 -
~ 2164$82
Above to the left, a variant is shown for the blocking of
the inner pressure spring(262), analogously to the so-
lution (just described) for the outer oressure spring.
It is evident from the dashed drawing of the bridge(866)
toward the support ring for the pressure spring(262)
that this bridge can rise over the latter like a loop,
when the springs are tightened and the device lid is
closed (c.p.Fig.13).
The series B/C more schematically clarifies pos-
sibiities for sclution with simply lined sketches forholding, as small as possible, the height of the device
in the cross section. For this, the pressure springs
(261,262), from which only one is outlined, must be
tightened ard the device lid must be bolted in a lowered
condition. The representation is given for A in the
middle in the vertical section in about natural size.
The cage or the frame(855) nominates structural
strenghtenings totally around the pressure springs in
connection with the injection cylinder, from which on-
ly cylinder(9) here is is skown, and to the suctioncup(1), from which roughly half was outlined. The
clamp(870) permits the shortening of the height, which
corresponds to the lowering of the lid.
The wedge slide(274) -with is again mounted in pairs-
is laterally installed in the lid to B. The bag (257,Fig.13) must respectively be made smaller for this. The
wedge slide is shoved away on the tongue formed ledge,
which projects downward through a slot in the lid plate
of the de~ice housing to the carriaye of the sliding
screw. The latter has depressed functional
stage the end of the hook of the lever(872) and
therewith the pressure spring in the shown functional
stage. The final bowl of the lever(872) is raised over
the knob-like end of the folded bellows of the injec-
tion cylinder ard is fixed by the stop bclt(104),whereby the countermotion is arrested by a locking
device (symbolized by a triangle).
- 54 -
'~ 216458Z
(The exact locality of the stop can also be determinedelsewhere)~
On the end of the support column(854), the lever(872)
can be tilted on a pivotal axle a~ainst the injection cy-
linder and simultaneously shiftable in the pivotal axle.
The lid of the device can ncw be depressed inside of the
free clearance of the clamp(870). When the lid is lifted
whilst creating suction on the skin in the suction
cup, the stop bolt(104) can be subsequently retrieves.
~ 10 The pressure spring(261) relaxes during the reduction
of the folded bellows above the injection cylinder, that
is to say, in operation of that.
The wedge slide(274) is arranged (according to C) on the
device bottom. Inside the frame(855), the wedge slide
lifts, wher, slidinq. to the right, the pressure spring
(261) into the locking device (not shown). The clamp(870)
remains thereby stretched out; the connective st.rap is
lifted together with the support ring(869) while the lid
(260) is opened.
2G In the middle representation, the lid was depressed, but
also again the connective strap(856); the clamp was push-
ed together and shortended thereby. (The lowest level of
the device is reached therewith).
In the partial stage to the ri~ht, the lid was lifted for
the suction production and the clamp was tired apart, so
that the u~,per frame portion with the pressure springs
was also l~fted. First now, but while the skin is sucked
on, the filling up the in~ection cylinder can take
place. If not a additional overcoming latch is mounted
between the connective strap(856) and the connective
strap(267,Fig.8). After the pressure springs are releas-
ed, the functional circulation is again closed to the
stage which is closed to the stage which is shown to
to the left.
The double intermediate slide(876), which consists of
ledges in ccntact with the spring basket with the ball
- 55 -
~_ 216~582
bearings(87F), extends over the cross bar(877) to theleft in the Fig.) in its portion, which runs beneath
the release slide. The cross bar(777) is connected with
the broad intermediate slide(273). The tow line(978), the
5 middle of three, runs from the bolts(980,9~1) over the
circulation roll(979) to the control gear, so that the
intermediate slide, as to the same time also the the
outer slide(274) through the other tow lines, can be
ccupled off-from the double intermediate ledge(876).
1~ The mechanism for the cc,ntrol of the release delaying for
the pressure springs(262) in shown in the vertical or
cross section through the final portion of the release
ledge(269) and the lateral projection of the intermediate
ledge(269; below in the middle).
15 The small slide(273) is shiftably on the intermediate
slide by a turning screw on the intermediate slide with
the follower pin(879). The latter is taken with by the
ledge proiection(880) of the release slide. Its movement
occurs by means of the pressure spring(881) after the re-
20 lease stop(760) is activated by the cantrol gear.One can see from the frontal section (below to the left)
in the section direction A - B of the longitudinal or ho-
rizontal section, that the resilient bolt(832) permit the
retreat of the release and intermediate ledge, whilst the
2~ sliding screw(352) takes the wedge slides(274,275) with,
because the former has a rigid connection with the wedge
slides.
On the sketch (below to the ria,ht) one cen see, in a ver-
tica] or cross section, in which a manner the hinged sup-
30 ports(883), which can be hinged in a flexible ,iointagainst a erecting spring, absorb the pI essure of the
pressure spring(261) and transfer is to the release led-
ge (what is drawn also in the longitudinal section).
The release ledge is, about to the half, drawn back to
35 the left. (But the ledges have a wedge slant on their
ends). After the bolts are released, the wedge slides are
- 56 -
216~%~
then retrieved out from ~he proiection of the pressuresprings, which occurs by the s]iding screw.
The sLpports are pushed sidewards by the respective leaf
spring(884) on the ledge for the eiection or iniection.
5 The analogous fitting of the inner Pressure spring(261)
was omitted.
With the described device, it is taken into account, that
the pressure donator for the injection cylinders broadly
~ exceeds in power the pressure spring(881) for the
; lG release slide. An alternative is described in Fig.35 also
with an horizontally laying mountin~ of the pressure
springs(261,262). The operational expendidure can be fur-
ther reduced by a two-chamber injection cylinder adjusted
to the load of the device size.
Figure 18 schematically shows in both upper figures the
raising of the pressure donators for the iniection cylin-
ders and their relation to the lid area in a cross or
vertical section. Above to the left, an example is drawn
20 for the closing of the pressure spring basket through an
oblique lattice net, on which the rolls of the wedges
slides find slight resistance.
The lid(260) is lifted by influence of the pressure
springs(not shown; 259,FiQ.21) in a vertical section
25 through the detail above. The bag(257) for the suction
production with the aim to ]iftina uF the skin is enfold-
ed. The pressure sprin~s(261,262) are also released. The
wedge slide;274) with the s~iding rolls(874) still stands
outside of the pressure dcnators for the injection cylin-
30 ders. The stop bolt(104) lays drawn back in the releaseslide(268), the inner pressure spring(262) is shown to
the left, the one for the outer spring(262) to the right.
Below the vertical section skows the stage after the wed-
ge slide is mcved to the right and the pressuere springs
35 are tightened. The stop bolts are now urged in the re-
spective arressting notches and locked by the release
slide, which is drawn back before. The lid is lowered and
- 57 -
`- 216~82
the bzg is compressed under it.
A corresponding representation of a variation of the re-
lease of the pressure donators b~ the wedge slides is
given under this detail image in a longitudinal or hori-
5 zc,ntal section. The wedge slide(273) for the outer pres-
sure spring(261) is bipartite and surrounds the wedge
slide(274) for the inner pressure spring(262). But the
above described lattice net is respectively divisioned,so
that outer stripes extend bEtween segments of the outer
(spring) and the middle stripe leans on a bow segment of
the inner pIessure sprincl. The release slide lies ledge
formed outcide (in pairs),parallelly to the wedge slides.
Figure 19 describes the cQnstruction and the function of
~ v~lve control for ~luids to a scale about of 2 : 1.
This is done above in a vertical section, .in the middle
and below in a horizontal section.
To the left in the vertical sEction, the segment axis(201)
is connected with the base ring(885) and can be rotated
20 around the housing ring(202), nQt shown, which is firmly
mounted on the housin~cl. The latter ccntaines the fitting
sccket of the supply and derivation lines or hoses, the
latters from which are drawn in dashed lines. The supply
hc,ses are introduced from the back in the szme level as
25 that of thE derivation hoses.
On the stage of the left vertical sEction, the pressuriz-
ed air stream is set free in the direction of the folded
bellows with the thinning fluid or the thinner(90). The
thinner correspondingly flows through the valve bcre in
30 the direction of the injection cylinders(9,67).
The discharge for the water is locked in the direction of
the injection cylinder. The stage, which is representated
to the right, shows the ccnditions after the turning of
the segment axis at ar angle of about 180 degrees. The
35 pressurized air is ncw able to flow toward the folded bel-
- 58 -
~ 216 ~82
lows(190) with weter and the water stream through the
lower fluid valve toward the shunt for the rinsing of
the injection cylinder.
Under this in the lon~itudinal section, two oFposite facing
insections are shown in the base disk or the base ring. The
contacts(207,2û8) for the signal to the electronic ccntrol
unit are drawn-in on the deepest location which contacts
with the rounded spring tongue (drawn to the right) stabi-
lizing the rotation stage. The base ring is rotated by a nap
10 pf the saw tooth ledge(886). The latter is moved there and
back by a bar in connection with the related functional
block (B and C resp.B or C) steered by the control unit.
The type of the tooth shaping determines in which
running direction the segment axle is turned.
The lower representation shows a simplificating alternative
of the mechanical power transfer (c.p.also Fia.5 )
The bar is replaced by a leaf spring(887) with rounded nap,
which engages in insertions of the base ring. The valve seg-
ment to the left is cut in a higher level ard illustrates
2û together the course of the valve bores whereby quarter
circle switching turnings are assigned with the possibility
of permanent rotation in one direction.
To the right, a pendulum running is assigned. The fluid
stream to the iniection cylinder(9) through the valve flap
(11) is achieved, as shown to the right, by the pressurized
9S out of the bag of the lid, this stream being introduced
there behind tue very reduced folded bellows for thinner
(90). The spring biased back valve(888) prevents a damming
up up of pressure and essentially facilitates the clos-
ing of the lid.The pressure toward the valve flap(ll) from the fluids is
regulated by the motor velocity, the throttling perhaps by
staccato or chopped electrical current supply, in such a
manner that the stronger pressure from the drug cartrid-
ges hinders the afflux or supply of thinner in case ofbigger drua amounts.
- 5~--
216~582
Fiqure 20 ~ives a kind of block diagramm or flow chart on
the functions of a valve, accordin~ to Fig.1~, to clarify
the air and fluid stream.
During the valve stage A, the bag(257) under the lid of
5 the device is compressed. The overpressure through the con-
nective hose(l2) closes the back valve(13)
in front of the suction cup(1), in comparison with this,
the back valve(286) was closed. The position of the valve
segments, which regulate the supply toward the injection cy-
10 cylinders, on the extent of the relieve of the air stream
; toward the folded bellows for water(190) and the streamin~
in the hose(25) for water. But because the pressure relief,
by the ventilation with valve switching over to the func-
tional sta~e A, these lines or hoses are pressure-less.
(The same purpose can be reached, b~ omitting the back
valve(286), if the filling procedure in the iniection cy-
linders is iust finished during ]id depression). The
pressure regulation through the back valve(888,Fig.~9) is
- si~nificant in this case.
Figure 21 shows in a cross section along the section
line C - D of the lonqitudinal section of Fig.9 the
arresting mechanism of the device lid in natural size.
The device serves to the air compression for the expulsion
of fluids and for suction production for sucking the skin.
The attachment of the bag(257) above on the lid(260) and
below on the covering plate(283) is achieved over a longi-
tudinal ripe profile of the bag in a parallel arrange-
ment, which is shoved in corresponding grooves of the at-
tachment s~:rfaces. The profile is drawn at a distance, to~h~ le~t, in the form of a dovetail, to the right, meander
like. Or. the base or socket st.anding on the bottom of the
device, the carriage(288) is slidable along the rail(289).
The tension spring(290) prevents that the flanged nozzle
(258) can b~ aepressed and with it the lid(260), connec-
ted with the ~ozzle. The cGrd(291) must be pulled first
~ 216~82
by the control gear (functional block A) over the roll
(292; flanged nczzle to the left). When the flanged noz-
zle is depressed against the pIessure spring(287; to the
right), the border ring(778) of the flanges nazzle hc,oks
onto the carriage(288). The latter is represented with
its rail guidance below in detail in a frontal section.
A rubber elastic mounting of the plates of the flanged
nczzle on the lid represents a lid of kesser-mount(780);
in this way a pawer safety lid closure is renc'ered pos-
sible by unequally (in time) pressing down the flangednozzles.
Figure ~'Lshows three solenoids in longitudinal section
and in a sc~ematical composition for functional release.
Their functional organes come in approximate natural
size as an alternative solution. The prolon~qation of the
anchor or rod(19) of the pushing solenoid(556) demon-
strates its operational direction with dashed lines.
The lid mechanism for the suction production was released
by the pulling back of the carriage(288) by means of the
ccrd(291) oYer the roll(292). Th'ereby the pressure sprinq
(287) was effective after the movement of the flanqe noz-
zle(258) wa~ released. The tension spring(290) has already
brought back the carriage again in its lockin~ pasition.
When a border ring(778) is used as in Fig.21, an inadverte
lid sinkin~ is not prevented with reventilation of the
suction cup.
The solenoid(555) has nat yet released the release stop
(760) between the front slive and a ledge of the injection
carria~qe(731) and therewith the skin squeezing is nct
yet achieved. Opposite the sc.lenoid(556) the detail about
the fixation of the tension and pressure sprin~(8,732) is
repeated from Fig.4. The classed with lock(765) is ac-
tually activated after the release stop(760, above) and it
should be in an er~aged position for the leanina on the
tensioned sl;ring. (The latter are h~re in a released con-
dition befo~e the activation of the solenoid(556).
21645~2
Figure 23 sh`ows in a scale atout of 2 : 1 in a longitudi-
nal section a double working solenoid(563) for several sep-
arated release functions.
The guiding cam(564) serves herefore, which is fastened
5 through the hook(568) with the retaining beam(566) for the
partial rotation of the rotary iack(567). The rod of the
latter is activated by the argle piece(569) on the cross
stay(570) against a spring-loaded power transfer (nct
skown) to a operation organ. The annular sleeve(571) is
10 moved under the cross stay on the prolongated anchor or
rod(19) with the sclenoid activity. The up and down motion
is simultaneously turned over in a partial rotation of the
annular sleeve through a zig-zag groove on the inside of
the annular sleeve by the guiding pin(542) on the prolon-
15 gated sclenoid rod. The ring (plate) with the small(574)and large(575) sector slot is fastened on the annular
sleeve. The small sector slot can pass along the argle of
the angle piece(569), if the respective return position is
reached. A further rotation lockes the return of the cross
20 stay urder the influence of the t-ansion spring(572) on the
cross beam(573). As soon as the large sector slot permits
the angle to pess, a releas function is operated by the
tow line(303`. Further operating bars(576,577) can be ac-
tivated, one after the other, by the partial sectors under
25 the annular sleeve. Pushing functions are possible as well
through a swiveling angle piece resp. a cross pin on the
rotation iack(567) as tension functions (by the cross pin
on the rotary iack or the grasping through the sector
slots(574,575)). The slots can be adjusted in such a m~n-
3C.ner, that the release of the return of the angle piece(569) by its tension spring occurs in a shorter interval
after an operation stroke by the solenoid as a second
stroke of the latter (because of its response latency).
3sFigure 24 shows at a scale 2 : 1 a toothed wheel with
electrical record and a clearance of motion, as it can be
used mainly for operation gear wheels, the oFeration
- 62 -
-
~164~82
function Gf which works or.ly to one direction. The insu-
- lin metering is an example of this. The axle(223) is
surrounded from the electrical noconducting isolating
ring(224). The drive pin(225) projects from the axle
sleeve(230) and pushes against the stop pin(226) which
is roofed by the spring tongue(227).
To the right of the frontal section, a longitudinal sect-
tion is shown in the section line A - B. The toothed
wheel comes between the leaf springs(228,229) on shifting
lG laterally. The spring tongue(227) is suitable then, when
drive peg iS adjacent to the toothed wheel; the side,
turned to the latter, of the drive pin must be isolated
then (c.p.cross section B - C above). The current flow
over the axle toward the leaf springs(228,229) can be tap-
ped. As suitable a tooth or any teeth either can bc iso-
lated or not; the no-isolated allows ccntact with one
or both leaf springs(228,229) that the number of rota-
tions are ccntrolled. The current conduction over the
drive pin perhaps to one or any no-isolated teeth(231) on
the counter side of the drive pin allows the free clea-
rance of the gear, perhaps on a function less passage of
the contrel toothed wheel or pinion to the other operat-
ing wheels.
Figure 25 shows, above in a vertical section to a scale
of 2 : 1 and below in cross section in a scale of 1 : 1,
two lid blinds for the nczzle, which, positioned or their
own radia, are moved past the nozzle through the suction
cup roof.
(Below in the cross section, the pressure donator(81) and
the iniection cylinder(9) are omitted, but also the suc-
tion cup(1) with the edge rounded for sliding past the
skin, the i~ack valve(13) and the throttle valve(57B) in
the ventilation channnel ard the skin, which is raised
up under the influence of suction and drawn with dashed-
ard-dotted lines.
- 63 -
~_ 216~582
The segment like skaped covering sleeve(337) with the heat-
ing wire for the germs killing at the area of nozzle is yet
drawn away (below in the horizontal section) from its posi-
tion over and behind the lid blind(309, above in the verti-
cal section) by the toothed wheel(582) and the inner axle
through the suction cup roof. The follower pin(586), which
; proiects from the toothed wheel, now strokes (as shown in
the vertical section above) against the radial slide and has
tightened the tension spring(588) between the fastening ang-
10 le(590) on the ratation disk(589) and the radial slide. The
rotation disk ~s connected with the swivel arm(584) for the
segment of the lid b].ind(309) through the axle sleeve(585).
(The axle sleeve is ti~htened in the bore of the suction cup
roof ard toward the axis(591) for the swivel arm(584). The
15 sectoral shifting of the se~ment o~the cover sleeve(337) has
taken place immediately before the suction is introduced in
the suction cup. The tightening of the tension spring(588)
is increased immediately before the injection to such an ex-
tent, that the ball stop(592), which is resilient against
20 the suction cup roof, breaks out of-a stop notch.
The segment of the lid blind(309), which is not turned away
from the nozzle, now activates the injection procedure.
(The injection beam into the suction cup is shown with fine
dashed lines above in the vertical section).
25 For reventilation, the air escape can be activated later-
ally urder the beck valve throuah the o,aening of the
throttle valve(578) by a lateral air channel(593).
Figure 26 gives an alternative solution for nozzle cav-
30 erinq outside of injection of drugs or ejection of wæter
for cleansing. These covers are thereby lifted
before the pressure dc,nator is activated.
Abave, a vertical section through the suction cup is skown
to a cale 2 : 1 of, under this to the left, a horizontal
35 section to the scale of 1 : 1 in the level A - B (also in
the level of the beam) of the vertical section as a detail
of the ervirons of the iniection cylinder.Below to the right,
- 64 -
'_ 216458~
the surroundings of the nozzle is mc,re illustrated ina scale about of 3 : 1.
The cross stay(554) is l~fted along the grooved rail(595)
by the skin, which raises under the influence of suction.
5The sectoral like cover sleeve(337) with its heating wire
loop together with the leads is also thereby lifted with
photo emitter ard photo sensor with leads from the suction
cup roof. (In the detail below to the right, it is in each
case or,ly one lead end dEmonstrated and the ccurse of the
lOleads inside of the suction cup in the longitudinal section
above). The light beam which controls the skin condition,
for example, projects perpendicularly on the inside of the
sector of the 'id blind(597).
The cover sleeve(337) has the passage(597) for leading
15past of the mirror nose and the light passage. The equip-
ment for the reventilation corresponds to that of Fig.27.
The photo emitter(580) and the photo sensor(581) is drawn-in
with its laser ray connection for the injury free metabolism
measurement, mainly for glucose, without lead ccnnections
20and the respective analytic apparatus. Relating procedures
were filed to the patent in the Federal Republic, first,
from Nils Kais~r (Untergarching) and Arnold Mueller (Ulm).
As alternative for the heating wire(239) in the blind (be-
low), the heating wire was p~t around the nozzle above.
25(The latters can be otserved on the dashed-dotted drawn
fluid beam). As alternative for the optical ccntrol, light
ccnducting fibres(982,983) are drawn-in below near the nozz-
lefrom the emitter to the sensor.
The wedge(334) on the release bar effects, if it is de-
30 pressed (or in other cases, if it is lifted),a shifting ofthe strap of the lid blind on the guiding slot(558) and
therewith the release of nozzle (3, which is outsized).
Figure 27 repr~duces, atove in a vertical section, below in
3sthe longitudinal section te a scale 2 : 1 a suction cup
with a blind(889) for the nozzle(3), which is shoved uFIwards
- 65 -
2164582
by the skin itself while it enters into the suction cup.The exit of the injection beam out of the nozzle of the in-
jection cylinder(9) is marked with dashed-and-dotted lines.The
annular blind(8~9) has bent hooked pro~jections(890) toward
the skin ard a weak replacement sprin~q, which works as a
pressure spring (that is to say at least three on the
circle circumference), supporting the laying of the blind on
~he suction cup edge.
lG As shown in Fig.26, the blind ring can have a perpendicular
rail ccnduction in the suction cup; it can receive photo
measuring devices. But also an electrical lead can ccnduct
to the heating wire(239), to liberate the blind i.tself and
the suction cup ec'ge again and again from pathological
germs. The material of the blind must be chosen with appro-
pIiate heat resistant quality; perhaps coated here
ard there with teflon. The ring contact with the suction cup
edge can be intensified by magnet inlets. But also the form
and the m2terial shaping can be useful to promote the sudden
2C! jerking of the blind, if the suction cup is pressed
against the sk;n. But the resistance of the hc,ok proiections
dLring the raising of the skin by suction can also support
such an effect that the nozzle is quickly closed by the skin.
The blind ring can be ccnstructed smaller than it is drawn
ard be additionally supported in its raising by cross *can
~ys(594). The air derivation occurs through the ccnnecti-
ve hose(12) to the vaccuum source.
3û Fi~ure 28 shows an optical skin control mechanism inside
of the suction cup (atove in a natural size) with (even-
tually) controllable nozzle valve(378).
The in~jection r.ylinder(9) projects under the pressure do-
nator(81, in deshed line bccause it lays behind) into
the suction cup(1) being sectioned-on behind).
The transparent glass or plastic measuring window(579)
lies immediate~y under the nozzle(3). Beside, -for exam-
_ 66 -
~ 21B~582
- ple, the area of the suction cup rim,- the light measur-
ing arrangement with light emitter(580) and light receiv-
er(581) are shown.
Below the detail of the optical control device is repeat-
ed at a scale of 5 : 1. The skin fields or pattern are
lattice like drawn under the window(579), additionally
the light beam from the light emitter (or transmitter, as
from a LED or laser) through the window, there reflected
from a concave ec'ge against the skin back over its ccn-
cave edge into the light receiver. From the cable connec-
tions are reproduced in each case only t~o on its final
segment. During the raising of the skin, the skin pat-
terns are drawn past the window. The computer classifies,
after the stand-still of this motion out of the stored
~5 skin portion measuring fields the over the nozzle resp.
over the diaphragm the area of the nazzle (or cannula if
used) laying measuring field with the cc,rresponding light
exstinctions considering the speed of skin raising. (A
task which is performed today by any PC-CAD-programme ana-
logously). It cen bc determined in such a manner by thebreaking off of the functional running without injection
before the lid diaphragma is opened (or a cannula is
pierced, if any). In the cEse of mc,re imparts of pig-
ments or in other kinds of imparts from comparatively
normalskin, deviatin~ skin area -at a spotted su:rface p~t-
tern (perhaps with akne or with freckles)- the skin knob
can be lowered slightly by the opening of the narrowly
placed nozzle valve(578) and the puncture can be perfor-
mcd at the moment in which a probable healthy skin area
lies over the (iniection) nczzle (or cannula if used).
Figure 29 shows a plan view of the preferred form of the
device (c.p.Flg.9) after the arrangement of the inner
mechanical eq~ipment is concised. The position of the
suction cup(1) and the insulin cartridges(113,114) as
well as of an~ cannulas (or sleeves with sensor threads,
Fig.47-54) is shown through the break off, above which
- 67 -
~ 2164~82
the subsequent described surface equipment
is continued. A sensor ccntact(817) corresponds to each
circle on the rows of the device surface, with said sen-
sor ccntact(817) reporting the finger contact,in the kind
of eerth fault to the control unit, ard activates a
shitch. The tcuching is suitably confirmed over a li~ht
sc;urce, which makes the touchina pcint ]uminous. For this
aim, a pin with flasky cclour face can be but roofed at
the end by a transparent pot(818) which is depressed
rl against a sprina and catches with an edge ring behind the
ledge(819),1ightening up the colour field during its ~ix-
- ing. (Detail atove to the right in a frontal section).
The ledge(8~9j has regular edges recesses, as the cross
clears urder the detail. Suches ledges can extend ncw
along in each a row and can be operated, mounted at a ccm-
mc,n spring resilient frame, so that all pots are released
for the upward movement. A similar (perhaps inverse func-
- tioning) device renders possible the reading out of in-
puts also tc, the blind. Display windows -perhaps as a
fluid display~ ccntain a time scal~ w~ich mc,ves from abo-
ve to below. The patient ins now able to report, coordi-
nated to the intended meal, also with regard to ites glu-
cc,se ccntent, to the control unit by means of the in-
fluence of the pressure against the sensor contacts.
2~ Because the ~lucose content of the food is reduced during
the progress of the digestion, an approximate triangle fi-
gure with a large base be~low comes up to this operation.
The basis breadth should be indicated on a larger record-
ing tape thereby with hi~her glucose ard starch content of
the food. The precision of this programming can be auxi-
liarily improved b~ ccmputer, but essentially that can be
exercised mainly with the control of the results indi-
cated on a recording tape(see below). The extent of plan-
ned body activities is expressed, time related, in Watts
on lateral rectangles by contact oFeration. Exiting from
the actual measured glucose tissue level and consider-
ing the input of personal insulin working constants ard
_ 68 -
;
216~8
'_
the working profiles of the used insulins, the height andthe mixing relation of the insulins is nc,w explored by
the computer and the decreasing triangle of these is
brought about in ccncruence with that, wl~ich the patient
5 has drawn in; if it is necessary to warn against absurdi-
ties of the programming, the injection is performed accor-
ding the dc,sage. For example, ar input of the food and
labour charge is drawn-in in dzsh-and-dot lines, formed a~
two triangle-s and two rectangles betweeh the sensor cc,n-
tacts. To the right, the virtual imaoe of the derivated
computer operation is shown, The programme inputs are
drawn in dashed lines, whereas the computing results are
reproduced in dash-and-dot lines. Dangerous outline break-
downs(821) induce the computer to warnin~ signals while it
15 marks the date in case the gape can be closed
only with disproportionate dosage alterations. The pa-
tient shall then cc,mplete the food or take a measurement
at the questionable date.
This extension of the possibilities for programming ex-
ceeding the condition of PCT/DE85/00313 on 1985, now
allows dcsage adaption also of the depot insulin adjust-
ed to the planned routines of the day by the p~tient and,
therewith, a rrore independent life style.
The dosage intending special program blocks adapted to
the course of day (sport or bureau day) and the fixa-
tion for laying down of steps for emancipation of the
p~tient related to his cooperation are, of course,
the further fundament.
One of any given example for a trial ar;d error defini-
tion of the constant or multiplication factor for a
dosage of immediatiely working insulin, may be propos-
ed: 60 rr.in. after a meal with 3 BE (bread units)and 90 min.
after the in-.ection of 10 Units insulin the meas-
ured value <100 mg% may stand for K = 0,5, <120 mg%
for K = 1;<140 mg% for k = 2;<160mg% for K = 3;<180rrg%
K = 4. For this aim (of programming) the hand switch
wheels(822) are arranged along the device well(16) to
- 69 -
~- 2164~82
ac~just, correlated to their scales, sensivity cc~nstants
~t ~th-~or warning) point with regard of the gluco-
se content and correcting frame as well as program
blocks. It shall still be mentioned that the device
could be used also only for diagnostic aim (also with-
out injection), perhaps for the control of substances
excreted b~ the kidneys. But the device could serve ex-
ceptionally for injection use, when accordin~c~ly simp-
lified, for example, for the application of heparine.
The sliding switch(717) on its rail guidance is st.ill
drawn-in above (c.p.Fi~.9).
Figure 3G gives a detail of the programmin~ board on the
broadside of the device at a scale 2 : 1 atove in a ver-
tical ~ection along the alongside of the device and below
in a corresponding hc,rizontal section. The example makes
more precise the sc;lution to Fig.29 and is a refinement
of that. Over the cover plate(283) a further lid
(219) is mounted on the side wall of the device detach-
atle wi.th its marginal ledge. The plu9(220) stands in
rcws with ccrresponding holes Gr. t~e lid(21)) into which
th~ pegs project. The hole is sc; large, that the trans-
parent cap or pc,t(818) on the peg(220) is downwardly
shiftable against the wire or leaf spring(22~). On account
of the leaf sprina(222) between the acjacent led~es(819)
the latter makes way for the slant of the arnular collar
on the end of the cap or pct(818) and the latter on the
steep f~ank of their annular collar in a depressed posi-
tion. A flashy (perhaps green) colour coat on the upper-
side of the peg(220) is visible thIough the pot. In
3C, case ~;he input with pressure up on the pot(818) is
cancel.led, the key(293) must be pressed there-
fore against the pressure spring in the guide clamp(294)
of the lid border or rim. The ledges(819) have regularly
spaced incisions or notches(295), so that all caps or
- 35 pots of the row return upwardly to the 0-position by
mcans of tneir wire ore leaf sprincJs(221) if the key is
- 70 -
~` 216458~
pressed. The movement of the ledges is made possible by
their recess(296,above). Each ledge is secured against
rotation by the profil nose(297). The profil nose sur-
passes the key sheet and can be turned between both pins
(298,299). After the glock-wise rotation up to the stop,
the profil nose can disappear in the slot(313) of the lid
rlm.
Figure 31 s~ows schematically, in a side view to a scale
lû about of 1 : 4, a device complex consisting of the hous
ing of a pressure iet suction injector with the battery
supply(255) and the space for the installation of the
chip equipment as the electrical control unit(80) for
mass production. For small series, the flat stacking en-
casement is plugged into corresponding sockets of thehousing by means of the contact and coupling pins(679)
with electronic equipment, perhaps a micro processor
with the related storing elements.
To the right of the iniector h~using, the encasement of
a charging device(677) is shown with its double plug to
the mains and the lead connections to the socket(682)
in the ercasement of the eiectronic control unit, the
The course in the functional blocks of a device according
to Fig.l -13 can correlate to the approximate following
scheme. (Thereby +++ indicates the rotation or shifting
to the right, and --- the same effect to the left):
I ++++ suction+eiection release/tightening of the springs
for the pressure donator/tightening of
the release spring
---- switching to II + piston retreat dosage 2/
release of the springs for the release slide
/delaying slide back to 0/switching to II
3~ II++++screwing back of dosage l--idling++additional thinnin~q/
metering dosage~
---- idling/ delaying slide/ switching to I]I
- 71 -
2164~82
III ++++ idling -- idling ++ additional thinning/dosage 2
---- fluid switching (between thinner and water) /
delaying slide / switching to I
Figure 32 is a schematical functional set-up of the elec-
tric circuit control. The operation of the hand switch
If the three sensor contacts on the rim of the suction
cup(1) report earth fault(301), fed from the battery
lG (255), effects the current to interrogate in the electro-
nic control unit (e.c.u.300), if a locking or prohi-
bition is programmed there. Influencing is only pos-
sible then over a hand switch wheel(822) or over the key
board on the lid(219). The next interrogation relates to
the presence of a cannula before the funnel of the suc-
tion cup.
The sleeves(691) for cannulas are suitably coated with
metal so that the solenoid(155) on the groove before
the funnel to the suction cup can escape. The conductive
bridge, which connects the spring clamps(152) between
the cannula on the groove and the ~eighbouring one(691)
is tapped over the contact on the groove and the con-
tact spring for that. The current stream between the
groove and the contact spring confirm the presence of a
sleeve with cannula. The counter or computer is able to
ascertain from the total amount of cannulas and from the
distance of each cannula from the spring clamps, which
close the chain, and from the frequence of use, if a
cann~la is yet an unused one. From the e.c.u.(300), the
command starts for the opening of the seat valve(134).
After this, the question ensues over the light emitter
(580) and the light receiver(581), rather the skin, is on
the suction cup rim from inside. Light source and sensor
can be directly mounted in the funnel of the suction cup;
but they also can admit there light conducting fibres
and receive the latters(c.p.Fig.54). The measuring sig-
nals are measured at least on two adjacent skin areas
- 72 -
216~58
(-
(spots) and the grey-values can be compared one with oth-
er, as Fig.46 demonstrates.
The squeezing mechanism for the skin is released then.
The sliding sheets(9) have a slight deflection of their
5 edges downwardly to the skin. They have a sharp bottom
edges and a cross rippling of the edge region. One may
eventually renounce the application of suction before the
squeezing of the skin.
Before the suction release in the functional stage B of
the hammer(121~ the release of the stage A is due
to change a used cannula and to seal the funnel to the
suction cup with a new one.
The interrogation from the light emitter and sensor takes
place again by the e.c.u.(300) to cantrol the scheduled
prick-in area. If the differences of measured values are
too high, a command from the e.c.u.(3ûO) to the motor
shall be emitted to produce suction again for a itinera-
tion of the measurements while the skin is yet slightly
drawn back.
Figure 33 gives a horizontal section through a device for
injection, which can be operated with single drug car-
tridges and can be used by several persons without the
denger of tra~sferring infection transfer. The scale is 1
: 1 . Below ta, the left, the appropriate gas iet pump
(442) is represented.
The gas jet cr beam pump stands in connection with the
pressure control throttle after a pressurized gas cap-
sule, perhaps with nitrogen, carbonic acid, or oxygen,
through the supply hose(499) as well as the pressurized
gas hose(893,894). The iniector itself is held together
from a ledge frame(895). This pertains to the base plate
(15) with the cylinders for the battery(255, not shown),
which are distributed in two single pieces, surrounding
the traction solenoid(555) up to the base plate(8g6)
which is a little shortened and therefore drawn as if
broken off. In the middle of the edge to the left of
this base plate, a tube formed sc.cket(897) for the in-
_ 73 -
2164~82
jection cylinder is inserted. The in-
jection cylinder builds a detachable portion together with
the suction cup(1), the gas jet pump(442) and the electronic
control unit(80) which are closed together by the bridges
(898,899,900). But this portion remains in a certain loose
unit with the base plate through the hose cannections and
the dashed drawn electrical wires between the control unit
and the battery, respectively the solenoid. The drug or in-
sulin cartridge(113) itself has the nozzle(3) for the injec-
tion on its free end. The cartridge can be grasped on its
edge which surrounds the injection cylinder, and whereby the
cartridge is bolted in both bayonet catches(901,902) from
which the first is mainly essential and works against the
sealing ring toward the suction cup. The base plate is in-
terrupted by slanted profile slot(903), the edge of which
is designed step-like , the reverse edge of the profile
glot ha~n~ ~ ~ec~st9n~) f~c;nn to each step level.
Between the base plate(15) and the slidina ]edge(905), the
folded bellows is inserted, again in pairs. As pressure
dcnator this is preferably a metal folded bellows. The
sliding ledge can be moved in the interstice between the
base plate(896) in front and the ledge frame(895), and
behind together with the plunger(906), which is fastened
~nto t~e ~liding ledge. This mcment is impeded by the peg
~907~. whi~h leans against the step of the profile slot and
which can be shoved with the carriage(910) on the rail(906)
of the sliding ledge cross to the motion direction of the
latter by the knob(909). The carriage can be impeded in
this shifting by the edge of a tongue, which is connected
with the carriage through the hinge(911). This happens if
the tow line(912) is shortened against a resilient spring
by the rod of the traction solenoid(555), because one end
of the tow line is fixed on the mentioned tongue. The suc-
t;cn rup, the gas ~et pump, and the electronic control
unit are connected with the ledge frame by the clamps which
are sketched with 913,914.
The handle(915) is elevated from the base plate with circu-
lar cross section ar,d bends then as if on a trowel to the
- 74 -
2~ 8~
solenoid. It can be clasped with four fin0ers, while thethumb shifts the knob(9C9). The carriage under the knob
is partially drawn below in the vertical section to a
scale of 2 : 1 .
5 On the detail below to the left, the construction of a gas
jet pump is shown to about natural size in a vertical
section. The gas stream runs frùm the supply hose(449) of
the pressure control throttle throu~h the exit openings
~j:
or, the point of the hi~h valve cone(505) into the nczzle
chamber (50Q). Air is dragged along out from the sucking-
chamber(502) and thereby air is sucked on from the
cc,nnective hose(12) to the suction cup(1), at the dist-
arce to the ertrance into the funnel(505). The resilient
back valve(13) prevents the air from ertering into the
~5 suction cup, after the jet pump is turned off. The latter
is fitted with a suction switch to interrupt the gas ad-
mission stream, when sufficient negative pressure exists.
This occurs after an appropriate negative pressure is
dammed up behind the elastic membrane(503) throu~h the
2G suction lead(506) in connection with the connective hose
(~2) from the sucking-on chamber.
A central pin is connected with the valve cone through
the pierced support wall(504). If the suction essen-
tially exceeds the intensity which is needed for the
~5 sucking of the skin the elastic membrane(503) and rais-
es with it the valve cone. The latter closes at its end
the lateral gas inlet openings and halts thereby the gas
supply to the nozzle chamber(500). As a variant, the
cone pin, which projects from the membrane can also
reach up beyond the nozzle chamber, and it can
stop the gas beam there (not shown). The suction dam-
ming up inside the suction cup can be recorded by the
appropriate contacts, which are moved by suction, to
the control unit(80) and from there a signal can be re-
leased. The s3me is practical, if the optical controldevice for the skin confirms from the segment of the
_ 75 -
2164~8~
ccver sleeve(337) unobjectionably anatomical condi-
tions on the injection area. (As described in Fig.
25-28,53,54) the ccntrol unit releases the injection
nc,zzle free.
A small folded bellows(916) is beared forward to the
piston(10) with the tissue friendly rinsing fluid or
thinner. The latter is pressed against a annular edge
behind the nozzle opening and has a prepared breaking
zone. When the knob(9~9), caused by the gas supply into
the folded bellows(432), is moved downwards and release
the mction of the plunger(906), the rinsing fluid is
pressed through the skin (after the drug and the
destruction of the prepared breaking zone) without
interruption of the beam.
If the drug ampule or cartridge is destined for use as
a step syringe, the small folded bellows(916) with
rinsing fluid is omitted. The knob(909) is then moved
upwards (that would mean in the drawing: to the right)
and delivers the appropriate partial quantity of the
drug through the nozzle(3), which runs ot,liquely in
this case, into the upper skin with the formation of
a skin bladder or lump there.
The suction cup is thereby placed on anew for each bladder.
The heating of an incandescent wire around the suction cup
must be recommended for the germ extermination before
changing to another user.
Above to the left, rectangularly turned toward the inJec-
tion device in the middle, the detail of a variant for
the powder injection is shown in the horizontal section.
The drug powder(984) is stored inside the cartridge(985),
protected by protective membranes(986,987) against the
skin(986) and behind (987) it. The cartridge is tied past
in a chain with thread connection before the suction cup
(1). The membrane(986) is destroyed in the trough or nap
depression(988) with the heated pin. When the cartridge
is fur~her transported to the funnel, it is pressed
tnd sealed by the pressure tube(989) into the funnel.
_ 76 -
2164~8Z
After the posterior membrane is destroyed by heating,
the appropriate powder is shot throu~h the skin by a
gas stroke. An addition of dosages with or without dis-
placement of the skin is possible, while the funnel ori-
fice into the suction cup is tightened intermittently
by the cover sleeves(337).
Figure 34 demonstrates spectacles for diagnosis, as they
10 are suitable ~or metabolism measurement, preferably for
the measurement of glucose in the anterior eye chamber.
Above, a frontal view is shown, in a scale about of 1 : 1
after the carrier beam(929) in which the device appears
over forehead, nose, and ears, and it seems to be set up
15 around the eyes. Below the left eye, the arrangement of
emitters and sensors resp. of the mirror ledge is shown
with dashed drawn light ray way to the cornea dome, which
is protuberant in the center, and to the eyeball curve
whereby the eyelids are omitted.
2~ To the left, in the middle, a horizontal section in the
level of the handle-like carrier beam(928) is drawn.
Below still further details are described. (Pro~jections
lines for the attachment of the different portions for the
different views are given dashed-and-dotted).
25 The spectacles are installed here for measurement on the
right eye. The overlapping of the pcrtions of the head-band
(9JO) and its spring clamp are not shown, because this
e~uipment is known from every support device for medical
frontal specula. The bows, which project up to behind the
3Cl eyes allow an additional fixation on the heighth, the nose
bridge(931) securs against a lateral shifting. The elec-
trical motor(478) lies inside of the electronic control
unit(80) on the bow toward the ear to the right, the bat-
tery(255) lies on the bcw to the left ear. The adjusting
3~ wheels(932,933,934) are fastened by projecting an~les.
From them, the distance screws are adjusted in the depth
_ 77 -
~l6g~82
through flexible shafts (which are only drawn in itsinitial portions) and through the cannective strap of
the carrier beam(928, in the middle). Balsters(938) can
be shoved UF to its curved knobs. The support of the
S bolster(937) on the end of the distance screw(935) bet-
ween the frontal bone and the eyeball on the upperlid
ccrresponds to the adjusting of the adJusting wheel
(939). The ad~justing screw serves also to the support by
means of the bo~ster(938) on the lower lid between the
cheek-bone and the eyball. (The belonging distance
screw lies below the distance screw(935) and is therefore
not shown). It is driven by a threat on the adiustina wheel
(933) through the toothed wheel(944) and has also a cc,unt-
er running thread against the distance screw(935).
The distance screw(936) is oFerated on the ad~justing screw
(933) and the position of the bolster(939) between the cor-
ner of the eye, the nose bane, and the frontal bone is
therewith destined. (Under the distance screw(935), the
eyeball is drawn, and this dashed for its always not visib-
le portion. It corresponds (that is to say: their standingfor) to the springs and the distance screws, that the
rounded end of those, or which these pressure springs lean,
are carried from the respective inner pin and is pro~jected
in such a mcnner against the face; this singularity is
omitted in the drawing). The distance screw(932) promo-
tes the curved bolster(940), which is put against the
bow of the cheek-bone bow from outwards.
The distance screw(941) is driven through the screw sleeve
(942) and the ~;ransmission toothed wheels(54) by the mator
3û axis(53). This distance screw(941) brings the frame(944) in
a different distance from the eye by means of the angle bar
(949)with the rail below the outer carrier beam(928). The
inner rail(945) extends on and under the parallel portion
of the carrier beam(929) into the direction of the headband5 (c.p.the lower detail in a horizontal section). The blind
_ 78 -
215~2
visor(947) is tipped up between the double hinged ioin(946) before the metabolism measurement.
Both light ledges(951,952) are thereby erected toward the
eyeball. A light scurce (not shown) is directed against the
5 eye through the central hole of the blind visor as assist-
ance for fixation. The adjusting wheel(949) on the frame
(944) permits an ad.justing in the heighth of the blind
visor, the adiusting wheel(949) being therefore coupled
through a flexible shaft to the adiusting wheel(950)
(c.p. the detail of the adiusting wheel(948) in the fron-
tal section, below, quite to the left, and the detail of
th~ ting wheel(950), iust to the right).
The light ledges, w~ich are shown under the left eye,
are again stressed below in its position toward the eye-
~-5 ball in a scale of 2 : 1. The light ledge(952) might serve
as a broadly and drawn with dashed lines radiating light
source (the light is her drawn as dark hatching). If one
has looked towsrd the fixation light of the blind visor,
the cornea projects a shadow to the light ledge(951),
2û along the length of which sensors~are distributed.
The optimal depth adjusting for the metabolism measure-
ment can be adjusted by rotation on the electrical mo-
tor(478) according to the distribution of the measured
values which are recorded from the electronic control
unit.
If a second such light ledge arrangement is present,
turned about a right angle, the adjusting of the frame
(944) on the ~djusting screws(948,950,953) can be per-
formed automatically with the help of the computer and
the mctor, and with the interpolation of a respective
control gear. During the putting on of the spectacles
for diagnosis, the blind visor and the light ledges
suitable are still held in distance from the eye, and
they are carefully approached to the latter.
Just to the left, the light ledge(951) is drawn again in
scale of 4 : ~ from above, to demonstrate the example of
- 79 -
~ 2164582
a glucose measurement. A light beam might be projected fromthe photo emitter(580) to the opposite positioned light
ledge tnot shown) and it might be reflected by a small mir-
ror(955) to a mirror of the light ledge(580). This proce-
5dure can be repetite along the light ledge, but also on asingle measuring straigth line, then proportionally to the
duration of the light flash. The photo receiver(581) is
able to ascertaine the contents of glucose on the basis of
standard comparisons of the differences of the measured
10 values. One can utilize either the alteration of the pola-
rization plane by sugar or the alteration of the dispersion
angle of laser light or other known methods. Of course, the
spectacles for diagnosis can also abe installed exchangeab-
le for the other eye or can be elaborated for both eyes.
~5 The electrical-electronic control unit(80), suitably con-
taining a recording device, an alarm -clock or flashes-,
a memory for the ascertained measured values, and a trans-
mitter which works in the directiuon to the injector or
to the common or system recording device, which unit is,
20 as the rule, connected with the charg~`ng device (on the
mains). The electrical wires between the control unit(80),
the light source on the blind visor(947) and to the bat-
tery(255) are drawn not resp. interrupted.
25 Fip~re 35 shows schematically the detail of two pressure do-
nators by means of laying pressure springs(261,262), which
are parallel to the device. (The other functional
portions are omitted; a broadening of the injector could
be the result of this solution in its total conception).
30 Nevertheless, the pressure sprin~s(261,262) can be connec-
ted with auxiliary spring segments(962,963) through cross
stays(960,961), which are fastened on rigid connective bars,
so as the vacant spaces in the device can be used.(The au-
xiliary spring segments were diminished to about 8 : 1 be-
35 cause of the need for space). This connection of sprinosin row can be productive for this, because the level or ex-
- 80 -
216~C~8~
tent of the piston(10) stroke figures at between 10 and 20mm totally.
The power transfer occurs through both angle bars(964,965),
to which final plates the pressure springs(261,262) support
respective to which final plates the connective bars(958,
959) are fastened. The counter bearing of the pressure
springs(261,262) is built by appropriate strengthening
of the housing wall(16).
The pressure syringes are tightened completely through the
sliding screws(352) by the rotation of the screw sleeve(850).
Both solutions ~or the injection cylinder(9) are analogously
valid for the iniection cylinder(87). The locking of the bars
occurs by the release slide(268), which is urged away from
the cam(966) on its roof-like wedge slant(961) in the des-
cribed functional stage.
The annular grooves as locking insertions on the angle bars
are shifted to the left relating to the piston lowering.
The release wheel(968) therefore operates an eccentric l.ever
2Gwhich brings the release slide again -in a locking position
toward the angle bars with the annular grooves, which are
shoved to the right. This happens over that cam(966) and the
forementioned wedge slant on the counter side of the release
25slide. Tension springs and tension spring segments in row
are also able to serve as a pressure donator for the iniec-
tion cylinders, if the power transferring elements are cor-
respondingly adapted. (The small stop fork to the left of
the release wheel(966), which is operated by a tow line,
3c,wcrks against the eccentric fastening axis of the eccen-
tric lever, if its spring serves as releacing power). The
symmetrically arranged springs and spring elements can be
ccnnected with a common angle bar, if a single injection
cylinder with a two-chamber system is chosen as describ-
ed in Fig.36. In this case the order of symmetry of the
distribution of spring pcwer is invalid.
- 8~ -
,_, 2~6q~B~
Figure 36 shows in a horizontal section, through the detailof an injection cylinder according to the two-chamber sys-
tem, an alternative for the sclution of the problem of the
cleansing of the injection channel by thinning fluid on a
5 scale 2 : 1 .
An oval or square housing(431) with partition(430) for the
clinging of the folded bellows(432) serves as pressure dona-
tors for the double piston arrangement inside the injection
cylinder. The folded bellows(432) centrally contains a pas-
10 sage for the screw(435), the thread-less portions in the ham-
mer bcre(70), which does not completely continues. The lat-
ter belongs to the upper piston and has a disk-like erlar-
gement or collar on its end. The screw is driven by a pin-
ion in the thread of the partition(430) by means of the
15 toothed wheel(438). The pinion les over this in a sheet
connection and is driven along by the screw, if the this
is depressed.
The latter is connected with the pair of toothed wheels(441,
; 442) through the flexible shaft(439). The pair of toothed
2~heels, runinng indepently, is also rot~ted by the operating
toothed wheels for the metering of both insulin sorts. But
this occurs in both rotational directions of the pinion by
mens of an speclal operating toothed wheel(441).
(The toothed wheel(443) is a portion of the ccntrol gear,
nct further discussed here). The stored pressure in the
folded bellows(432) is introduced throu~h channel connec-
tions (to the left only indicated with a circle) from a
; pressurized gas bottle through the pressure st.orage con-
tainer(457). The bolt or inner slide(472) is slanted
asainst the edge pro~jection(459) and stands under the in-
fluence of a strong pressure spring, which is surmoun-
ted, finally, by the gas store pressure.
Thereby the small bolt is activated by the bowden cable
(462) and taken into the slot on the box bottom(448).
Thereby a blind hefore the nozzle(3) inside the suction
cup(1) is also shoved away (c.p.337,Fig.14).
- 82 -
~,. 216q582
The elastic protective membrane(445) is stretched outover the piston(10) between the hammer sleeve(436) and
the thinner. The upper piston(970) takes this in account
with slight conical taping. Longitudinal srooves(971),
~.~ich terminate blind downwards to the nozzle in the pis-
ton(10) during the ejection are coincident with correspon-
ding longitudinal(971) and bottom(973) s,rooves of the in-
jection cylinder, so that the thinner can be expelled by
t~,e nozzle.
lG ~he filling up of the chambers takes place, bElow through
the flap valve(11) for the insulins and the thinner, re-
spective water, and through the connective hose(449) for
thinner resp. water.
Below in the middle, the detail of a two-chamber cylinder
is reproduced in which the elastic protective membrane i.s
replaced by the folded bellows(445,c.p.Fig.16). The con-
nective hose(449) for thinner is cciled, conducted in-
side the folded bellows through the piston(970) to the
valve flap in tha space above the piston(10).
The variant, below to the left, dispenses with both pis-
tons inside of the injection cylinder(9) and replaces
these by a folded bellows, which is compressed in the
middle a little by the annular spring(974). The fluids
are filled-in on both sides through the connective hose
(449) resp. the valve flap into the folded bellows(975).
During the emptying by pressure from the side of the pres-
sure dcnator, the spring ring(975) already oFens and
is held open by the entrance of the acutely locking or
opening pin(976), which is centrally inserted on the bot-
tom of the cylinder(9), so that finally then thinner
alone is urged ts the nozzle(3) instead of the drug.
In a variant, below to the right, the elastic protective
membrane is replaced by the folded bellows(455), which
extends from the side of the rod of the piston(970) to5 the ec'ge of the cylinder(9), The rod has a thread, in
- 83 -
~ 2164582
which the rotation by the nut activates the piston mc,tion.This nut is secured against a lateral shifting and has an
outer screw that is driven on.
In all cases, water or other clean fluid can be filled
5between the wall of the cylinder(9) ard the protective
membrane or folded bellows, which is not replaced bet-
ween the single uses.
In the case of an exclusively elastic membrane over the
frontal surface of the piston(970), a second sealing
lG membrane is necessary between cylinder and the backside
of the piston.
Figure ~ deals with an alternative to the mechanical
control gear. Abave to the left, the detail of a valve
15 segment is repeated in a horizontal section to a scale
about of 2 : 1 (c.p.Fig.l9).
Below to the left, a valve is shown as a kind of hase
or tube brake, above harizontally, below vertica]ly cut,
to demonstrate possibilities of diminishinpJ the
2G streaming of fluid into the iniect.on cylinder, if higher
insulin dosages are applied.
To the right in the middle, the detail of an injection
cylinder is pJiven in a vertical section ~simplified by
one iniection piston, c.p.Fig.16).
25 Above over .he breadth of the page, a horizontal section
is shown through the entire gear, below still special as-
pects.
The power flow runs from the motor axis(53) through the
transmission toothed wheels(54) to the toothed wheel
(643), then to the toothed wheel(642) on the square axis
(627). On the latter the toothed wheel(630) is resilient
in a bush ar,d shiftable with this and connected with the
sliding socket on the square rod(644) by connecting
sheets. The square rod directs a wedge against the spring
35 tongue on the pinion(80C, detail below in the middle).
Below to the left, the projection of ary toothed wheels
- 84 -
2164582
UF to the drive of a toothed wheel(645) for the meteringscrew is representad in a frontal section.
Above in the horizontal section, a upwards folding of
the axles was executed, to clarify the function. From
the four operating toothed wheels (above in the horizon-
tal section) both outers are destined for the drive
of the forerunning thinner into the injection cy-
linder. The derivation from the operation wheel to the
left was conducted.
In connexion with the ratched toothed wheel(702) on the
same axis follows the punched disk(446) with the bent
slot, in which the cam peg runs for nearly for one rota-
tion urtil it transfers its rotation to the toothed wheel
(648) for the operation of the hose brake (detail below
to the left) through the translation toothed wheels(54,
atove to the right). The coupling for the idling between
an operation function and the gear is omitted here; it
was dealed in Fig.13 (814,815,816). The resilient
brake(998) against the operation wheels should be
superfluous. The metered forrunning, that is to say the
elevation of the ccnnective strap(267), also occurs
through the axis of the ratched toothed wheel(702) by
the screw(357) in a thread bush, which is fastened on-
to the injection cylinder (9) over the flexible shaft.
The connective strap is here not connected with the pis-
ton(10, detail to the right in the middle), but it stops
the upwards movement of the piston inside the folded bel-
lows(445) which is filled with fluid. The combination of
the lifting of the piston with the hose throttling or
s~ueezing with the ccrresponding coordination of both
functions can te still more favourable. Whilst space is
permitted for the piston lifting because of a low drug
dosage, the hose valve slowly opens for the thinner
stream into the in~jection cylinder.
The construction above the third o~eration wheel termin-
ates in a ratched toothed wheel with postponed punched
; disk for the valve cycle (c.p.Fig.19,20) durin~ the other
- 85 -
216~582
metering screw (c.p.121,122, detail above, Fig.9) can be
operated by the adjacent middle (second) operation wheel.
The toothed wheel(645) serves with its flexible shaft to
the lifting, which occurs proportionally to the mctering,
5 of the connective strap(267) by means of the screw(649),
the thread bush of which is lifted, pick-a-back, by the
screw(357) and which is correspondingly connected with
the upper bush of the screw(357), the former being ad-
justable in the height. The connective strap can be
rotated.
The ccnnective strap is rotable around the end of the
screw(649) and is formed of a dcuble of the fork piece
(650) with a wedge on edge, adapted to the forerunning of the
stroke of the pressure dcnator (nc,t shown). The fork
pieces are held together by a spring-suspension (here as
tension and pressure springs) above the folded bellows
(445) with the effect to imped the latter. The flitting
down of the pressure donator urges the fork piece side-
wards by the wedges on edge, before it depresses the
folded bellows and therewith the pist~n(10) for the ejec-
tion. (The double point-and-dash lines for the demonstra-
tion with arrows refer to the connectedness of the vertical
and the horizontal section through the in~ection cylinder(9)
ard, that is to say, of the plan view toward the altered
region of the connective strap).
The swivelling away of the connective strap can also be
achieved through a lateral tow line or a rod, one of bcth
being activated before the pressure donator has toached
the folded bellows(445) or its strengthening plate.
3~ The solution in Fig.16 needs the rail guidance of the
thread bush or screw sleeve(857) along the cylinder wall
inclusive the spr-ng braking as resistance against the
pressure of the fluid which streams into the injection
cylinder, what weakens the impact of the pressure dcna-
35 tor
- 86 -
~, 216~$~2
The construction of the valve as tube-type brake, below
to the left, principally corresponds to that as customary
in the trade for drug infusions or approximately to the
hose pumps in the blood transfusion matters and in the
laboratories. The hase is led within and out throuoh bor-
es (which lay behind the section plane in the vertical
section) in the valve pot, whereby the hose segment is
stored at the edge. The hose is gradually narrowed on a
radial partial sector and the fluid stream is throttled
because an expansion of the pot wall (in the horizontal
section sickle-shaped) through a cross sleeve which is
introduced from the turnable lid (here spring biased).
The fluid v~ , above to the left, is suitably driven
as a double pump which is arranged as a store, one
over the other, by the same axis. The supply of water or
thinner to the injection cylinder can be completely
hindered by them. The leaf spring(654) serves to the sta-
bilization of the respective valve position; the leaf
spring(887) serves to the transformation of a thrust mo-
vement into the sectoral turning by carrying along with
it an excentric cam. (If the rotation of a toothed wheel
is translated to the rotation center through a flexibel
shaft or similar one, the leaf spring can be omitted).
The motor rotation is transferred not only from the
toothed wheel(643) to the toothed wheel(642) and there-
with to the square axis(629) with the pinion(8ûO) for
the function of the control qear. The rotation of a
~ toothed wheel which is positioned under the toothed
wheel(643) is simultaneously transferred to the tooth-
ed wheel(630), which can be shifted along a further
square axis and which permanently meshes with the pinion
(800) by the connective or holding plates(124) with the
toothed wheel, and which is slided along with the latter
as a driving e]ement for the pinion.
The representa~ion, above the toothed wheel projection
in a frontal section, relates to the carrying with or
transport of the pinion(800) by means of an elastic
- 87 -
~_ 216~82
spring or tongue and is a clapping dowm for the explica-
tion of the conditions around the square rod(644),
which are above merely drawn in the total representation
with irregularly dotted line. The springy wire bow(655)
on its dEvice base ledge is shoved more upwards and erec-
ted and supports the stabilization of the position of the
toothed wheel(630) meshing with an operation wheel in each
case. The springy wire bow exists also quadruple in a stag-
gered arrangement.
lG When the motor is activated, the pinion(800) shifts, for
example, to the right on the screw(8nl). Its spring
tongue transports the sliding socket or sleeve on the
square rod(644) as long as that meshes with the first
operation wheel, a circumstance which is recorded through
electrical contacts (not shown) to the electronic control
unit. By pole change, its rotation direction is now al-
tered, and the pinion(800) is lifted to the left as far
as it corresponds to the programmed operation function
through the operation wheel and the ,ioined toothed
wheels. The intermediately ratchet tnothed wheels ar ncw
able to let through the motor rotations during the shift-
ing of the pinion to the left without function. They
transfer then the operation function during the return of
the pinion(800) to the concerning operation wheel after
the motor poling is once more changed to the right until
the pinion contacts with the respective operation wheel.
A further shifting of the pinion to the right leads the
tocthed wheel(644) up to the contact with the second op-
eration wheel by the thrust of the sliding socket.
But the second operation wheel can also be passed over
by bringing, of course, the toothed wheel(630) into mesh
with the second operation wheel by use of the spring
; means cross to the motion axis of the toothed wheel(630),
but the former being then further immediately shifted to
the right (still in the tolerance field of the idling
- 88 -
216458~
of the punched disk). (A short chopped or staccato poleor direction chance at the motor is suitably to support
the clearance from the operation drive during the passage
of the operat~on wheel. When the pinion(800) reaches the
toothed wheel~803), the sliding socket before receives
resistance with its stroke, and the spring tongue of the
pinion crosses the wedye nose of the sliding socket. The
toothed wheel(803) is activated in the mesh of its lat-
eral naps(783) with the naps of the pinion, and there-
lG with, through the toothed wheel(793), the control gearup to the screw sleeve(850), the sliding screw(352) for
the sprinas of the pressure donator,
The pinion(8aO) must be led back under the passage of the
toothed wheel(630) through all operations wheels to the
toothed wheel(802) for the return of the sliding screw
t332). This is done with the aim,to rotate them together
with the screw(801) in the counter direction (to that of
the toothed w~,eel(803)). During this backward motion of
the pinion(800) to the left, it is possible to command
2G dosage corrections by the control onit according to the
above mentioned filtered pendulum method; but also the
return of the screw(649, detail o the injection cylin-
der) is possible. Two ratchet toothed wheels(as 656)
can be radially displaced arranged in a counter running
2~ working double for the exchange of the druy cartridges.
They can be used against a spring back stop for the
change of the effective direction through a fork bar
(dashed-and-dotted indicated under the screw(801)) on the
! slide switch(717,c,p.Fig.29).
As the ends of the fork of the drawn or outlined bar in-
dicate, an automatic sliding by the pinion(800) is also
discussed. For that, a stationary relisient roller(348)
is used on a roof slant(156) which is shved past under
that by a bar.
But two additional operations wheels with opposite work-
ing ratchet toothed wheels can be used for this purpose.
- 89 -
2164S82
Because the metering process does not occure simultaneous-
ly, the necessity of additional fluid valves arises.
It is derivated also from the hitherto described practice
to employ the way of the pinion, which is indeed already
destinated, for functions, which are fixed relating to the
number of rotations or the extent of sliding distances,
and from the practice, to use the screw rotations for in-
determined functions. The high translation for the slid-
ing screw of the pressure donator but could then have
the consequence of an overlenght of the screw or the
necessity, to activate, also in this case, the sliding
screw only intermittently in strokes by pendulum motions
of the pinion and the ratchet toothed wheel.
Figure 38 continues with a detail in the horizontal sec-
tion in a scale of 4 : 1 the task and its solution of
Fig.12. Mainly, where separate drives are used for the
metering(c.p.Fig.38,39), for the main drive for the tens-
ioning of the spring of the pressure donator, the prob-
lem is given, to arrest sliding mavements activated bythe bolt.
,, If the wedge slide(274,Fig.18) is moved by means of the
sliding screw(352,Fig.9,28) both final extents remain
avalaibly for other operation functions after the lifting of
the pressure springs. In comparison with it, an addi-
tional sliding device would require an overcoming
latch, if the sliding screw lead pressure springs(261,
262,~ig.35) in a lock. After the screwing back of the
tension device for the pressure springs, remains an eli-
3Q gible extent for a switching function with highly posi-
tional stability. The fixation of a connective strap
(267,Fig.37, detail of the injection cylinder without the
screws(649), against the fluid pressure in the injec-
tion cylinder, requires, for example, such a stop.
The wheel segment(794) is rotatable together with the
eliptical disk segment(667) around the axis(795, which
is transferred upwards into the arrow direction). In a
radial slot of the wheel segment, the rectangular tube
- 90 -
~16 158~
,
socket with the cross bar(666) is mounted against a
pressure spring. The cross bar was inside led past along
the stationary bent ledge(665) with undular profile, when
the wheel segment is turned on the cam(663) by means of
the thrust rcd(661) by the sliding screw (not shown) to
the left. Therefore, this cross bar is locked about in
the middle of this ledge(665). Further pressure from the
thrust rod has allowed, that the latter mc,ves over the
curved end of the cam(663). Thereby the disk segment
(667) was shifted away so far, that it leans from the
inside with its larger extent of the ellips~to the cross
bar(666) and fixes it on the curved groove of the ledge
(665) with the result of a locking of the motion.
The release of the stop happens, if the thrust rod(661)
overcomes the cams(663,668) and transportes again the
cam(668) back to the right.
A further cam(669, indicated with a dashed line) can be
mounted on the disk segment, against which the thrust rod
pushes during its mcvement back, resp. to the right, and
whereby it pulls the projecting e~ge of the ellipse away
_ from the cross bar. But the lever is fastened on this
for the activation of the operation function.
Figure 39 shows in a longitudinal section on a scale of
2 : 1 a small solenoid(478) with high speed, whereby
the motor axis(53) transfers its rotation through the
intermediate control or reduction gear(9g7) to the trans-
lation toothe-~ wheels(54).
3Q Figure 40 shows in the longitudinal section on a scale
2 : 1 a metering mechanism(c.p.121;Fig.9). TWG solenoids
(554,555) are joined together to the aim of metering
screw. The sGlenoid anchors or bolts wcrk against small
wedged teeth of a gear wheel (shown in a partially roll-
ing-up) with its spherical end. The gear wheel(637) is
-- 9 1
2164~82
rotated by the solenoid to the left(554) over a ratched
wheel, said gear wheel driving the metering screw(157;
Fig.33). The action of the s~lenoid(554) happens respec-
tively, but the rotation effect is increased by the inter-
5 mediate gear(997). The ratched gear wheels arranged to
run in opposite direction effect one with other the rota-
tion of the geasr wheel(637) or at ].east not hinder one
the other. Coarse and fine metering and therewith the
total metering can be effected quickly in such a manner.
lG The rotation and the arresting of the wheels shown in a
rolling-up are secured by disks with wave profil in which
the leaf spring(654) engages respectively with arresting
effect as shown to the right on a vertical view of such
a disk with spring. The leaf spring suitably touches elec-
15 tric contacts inside of the notches of the disk and
thereby reports to the electronic ccntrol unit the posi-
tion of a perhaps connected metering screw and the number of
its rotations. To turn back again the metering screw
out of the insulin cartridge after the drug is emptied,
" 20 the angled bar(163) projects from the bolt of the sole-noid, the end of which meshes to the wheel(161) with wed-
ged teeth (shown again in a rolling-up), if the latter is
approximated to the angled bar over the sliding bar(162)
on the cover plate of the hcusing. The operation gear
25 thereby takes the sliding bar with parallel axles from
the mesh with the laterally fixed gear wheel(160) which
had driven the :netering screw over a shaft with gear
wheel. The operation gear wheel(260) is brought into mesh
for this with the toothed wheel(637) over the sliding bar
30 (the springing along the axles being not shown), the for-
mer driving the metering screw over the shaft (not shown)
with toothed wheel. This is done correspondingly to the
other wedge tooth position in an opposite direction.
Figure 41 shows a schematical longitudinal section to
35 demonstrate the possibility of an combination of different
working way distances between the strong pressure spring
(261) and the trust rod(661) by the localisation of the
_ 92 -
-- 216~582
rotation axis(660) which destinates the effect of the
lever(872). The latter is joined with the spring(261)
ard the thrust rod(661) with hinges (drawn with circ-
les).
Reporting to the Fig.32 and the Fig.47-54 the following
can be understood, whereby the hammer(121) stays for an
guiding pin of sensor elements:
In the case the measuring differences are still to
high, the alarm(304) is activated.
The button(306;Fig. ) can be pulled then over the tow-
line(305) emerging from the seat valve(134) over the roll
(307) on the cover plate, to ventilate the suction cup,
in case the commands to the mc,tor for a tensioning of
the tension springs(729;Fig. ) was not yet succesful.
After suitable skin condition has been confirmed, the so-
lenoid with the hammer(121) is operated at the functional
stage B and thereby the cannula is pricked into the skin
and the sensor thread pushed under the skin. The solenoid
remains activated for 2 - 4 seconds resp. for the time
~ for saturation of the sensor thread with tissue liquid,
then the sensor thread is retired.
The current, derivated from the sensor thread, is admit-
ted to an amplifier to the measuring instrument and the
measured values signals to the e.c.u.(300). After the
measured values are ccmpared with the metering programme,
the solenoid(554) and the metering mechanism(125) re-
ceive, if need be, impulses for the injection.
The injection amount is counted and controlled on the
contacts(654). After the injection is completed, the
sGlenoid with the hammer(121) is activated again by the
e.c.u.(30C) at the stage D and-thereby the sleeve(691) is
retired and the suction cup ventilated and the retreat of
of the sliding sheets(9) by the tension of tension
springs(729;Fig. ) is initiated with impulse to the
motor.
The device can be used advatageously at night for pro-
tection against low sugar levels during sleeping. For this,
_ 9~ _
~_ 2164~82
this fastening rings or loops on the housing are provided
through which retaining webs are drawn. The device can
be fastened now with the suction cup against the skin of
arm or leg. The three point contact on the suction cup
with the skin activates the measuring function and
falling short of a determined measured value causes the
alarm to be activated. Because the sleeper is in the
habit of turning, the device usually comes out of
place always to new skin areas.
P r o g r a m m i n g
According to the dosage programming of at least t~o sorts
of insulin, be advisec' of the suggestions in WC 86/
01728 (In,jection device with sensor, PCT/DE 85/00313).
One proceeds there, first with the processin,q customary
in medical practice, whereby different insulin,sensivity
is considered with correcting factors on programming.
2G The advanded computer technique wit~ chips also for spe-
cial single problems today allow further improvements
for patients cooperative.
Thanks to the ~mplifications described in Fi,q. , one can
discern, for the future, between alterations of the basal
2~ secretion or the level of the basis rate of insulin
(set forth with page 95)
- 94 -
216~58~
and the individual sensitivity for insuli~. Additional to
- a timed input of planned meals with triangles and of
working energy with a stronger ccmbustion of carbon hy-
drates in rectangles, a one point input is made always
by push-button in the centre of the panel or key board be-
longing to the planned date of the next meal.
The computer compares now the fed planes -triangles for
the carbon hydrates ingestion(supply) narrowed at the
margins by rectangles for the energy ccnsumation- to the
rhombes -relating to the working insulin resorption-
which are altered by the individual correcting factors,
and tries a surface masking first for immediately working
insulin. If the chosen date for the next injection lies
out of the duration of effect of immediately working in-
sulin, the computer shall attempt a correspondance of the
surface with depot insulin, which it supplements with im-
mediately working insulin for the initial hours. If the
planned date for the next injection lies in too great a
distance from a still sufficient effect of depot insulin,
the ccmputer activates the alarm function and indicates an
earliér date for injection. In the case that the patient
uses the injector earlier as planned, the computer ccn-
siders the supposed effective rest surface caused by the
antecedent injection for the new programming. By effec-
tiveness checkings of the insulin after determined test
meals with a step-like increased load with carbon hydra-
tes, an eventual decrease of the insulin effectiveness
can be ascertained. It can be placed to account for the
existence of an estimable basal secretion. On this
base the insulin treatment is essentially improved in
the future.
The patient shall alternate timed notices of meals by in-
put with the key(top,c.p.Fig.15), if he took up other car-
bon hydrates a~ounts as planned originally, that is ear-
lier. The computer shall take into consideration these
corrections while calculating the next insulin amounts. Aswell as for the input of planned meals as for their sup-
_ g~_
216~5~2
plementary correction -of course also according to the
date- the patient can use the auxilary means of a food-
stuff table Otl the underside of the device. Pressure to
the respect:ve symbol or picture for quality and quantity
(bread or roli, egg, glass of milk a.s.o.) effects the
data exposition of bread units (b.u.) on the display
-perhaps on a sidewall of the device classsed with a re-
spective number of the key board or panel similar to a
grid square of a map, on the condition that the patient,
before he compiles his bill of fare, signifies the corre-
sponding period of input with the coordinated key (or
top) to the left, with which the computer classes the
point coordinaion. Of course the informations or inputs
relating to the planned body stress shall also be correc-
ted past and considered from the computer.
The plans as well as the corrections, as arbitrary addi-
tional dosage;, glucose measuring results, the allowed
play and the use of this as planned and administered in-
sulin amounts are made visible on time or topically, pre-
ferably on the cargo device in c~n~tact with the mains
but also in battery operation of the recording device.
The characterLstic lines -traced=fully executed;
dashed=planned; dash-and-dot lined=ccrrected- of the re-
cording facilitates the interpretation of this:
Laying or prostrate triangles again for the carbon hy-
drates feed, prostrate rectangles for power (output) whe-
reby the under ledge of the strip can also be used as
centre line. 'rhe glucose value of the blood or tissue
liquid are suitably printed up in columnes raising from
the lower str~p margin, the insulin metering in hanging
downward columns from the upper recording stripe margin.
The recording tool is peferably mounted across the
paper stripe ~r tape transport. Differences between ex-
pected (calcu~ated) and measured values can be clarified
by hatching. But the calculated insulin resorption sur-
faces are slgnified together with their composition of
different insulin sorts. (All this is demonstrated on
Fig.56) - ~6 -
~ 2164582
Figure 42 shows a segment of a recording tape of a recor-
ding device(80;Fig.31) with minimal indices belonging
to said device which are described on page 89. The standing
column with 150 mg% identifies the ascertained tissue glu-
cose level, the hanging columnes with 40E and 80E depot,the administered insulin amounts. The dashed triangle
(the half of this one which has, been input into the
panel) stands for a carbon hydrate load of 3 bread units,
the triangle with dash-and-dot lines m~rks the, a little
1~ later admittedly eaten 5 breath units. Above in the
quadrangle, the planned work achievement of 120 Watt is
drawn-in, inside of quadrangle and next to it the ad-
mittedly from 120 Watt to 90 Watt reduced, and a little
shortended and time-shifted achievement. The planned next
time (dashed circle) has been postponed until later (lined
circle). The glucose level was banked with 210 mg and
ccrrespondingly banked insulin amounts have been admini-
stered. The calculated deviations of sugar values and
insulin metering from the earlier exspected values,and
flashed the with signal connected warning with the pro-
posual to the pa',ient of an advanced later (next) control
time (circle wit~ dash-and-dot lines) are shown.
The time grid has bEen omitted.
Figure 43 sbows a tabular calculation of the insulin
dosages in consequence of the imput loads with meals and
achievements b~ the patient. A PC was used with the pro-
gramme QUATTR0 PR0 5,0 from Borland for a simplified
form and a an atypical case.
3c, To the left column, a time scale is shown with time date
to which 6 hours should be added. The column for the
sugar values follows with still underlaying insulin ef-
fect of earlier insulin treatment. Alway read from left
to right, three programm column succeed with planned
meals for 3 bread units(BU), 1 BU, 6 BE and 5 BE for the
- - 97 -
'- 2164~8~
lth.,3th.,and 13.th hour (real time 7, 9, 13, 19 o clock).
One supposes that the effect of immediately working
b~ginns first after 30 minutes and its working decreases
in 3 hours (whereby the sugar increases in 20mg% per BU).
The 4.th (broad) program column shows the influence of
a work achievement of 50 Watts for 3 hours, which ifluen-
ce decreases therethrough in further 2 hours
(16 to 18 o clock). Just to the right, the column re-
presentates the insulin levels, as added with the data
by the computer, which increase again because a
outsized dinner.
Figure 44 takes the over the calculation results of the
last column of the table Fig.57. One assumes, that imme-
diately wcrkung insulin depresses the sugar level about4 mg% per unit inside of an influence period of 2 hours.
The values for depot insulin amount to 2 mc% in 12 hours.
At the 1th operative column, the computer calculate the
the difference to 160 mg~ as the upper desirable value,
a~d then at the 2th column the ~alue accumulation
out of the tolerance limit, whereby 180 mo% are
defined as ~he upperst tolerance value and 80 mg% as
the lower limit. It results the recommendation for 28
unit an 33 unit of immediately working insulin for 12,30
o'clock and 18,30 o clock. The sugar level column as
intermediate value is now ifluenced by the apply of depot
insulin, as the subsequent column elucidate.
At ~Idsll (difference sugar) are in each calculation 10
tolerance windows are ccmbined, so that the injection
3û of 35 unit depot insulin at 17 o'clock is recommended
to be sure with a warning because of low sugar level.
According to the countin~ rangel 5 tolerance windows
were combined for immediately workin insulin.
Figure 45 diagrammes a statistic variance function for
the ascertainment of the time points for the in~jections
- 98 -
~ ~16~82,
using a time scale of 2,5 hours for immediately workinginsulin and a such of 5 hours for depot insulin.
(setting forth with next page)
Figure 46 shows a schematical set up of a device
for a skin control to the aptitude for a puncture.
A circuit leads from the battery (volt) to the light
source, the light through a lens to the test area of
the skin, and is reflected through a second lens to
lû a photo-diode a~ receiver. From there a circuit leads
to the amplier and voltage meter als measuring device.
Additionally to Fig.29 shall be noted, that the tri-
angles and rectangles, which the patient is adviced to
~5 input to a panel, shall serve, mainly, to the cleari-
ty. It may be suitable in the reality (because the re-
stricted nunber of possible keys on the panel) that
as well loads with carbon hydrates as thus with work
achievement are input by respectively two points in a
distance of a zero-line or by numbers. The computer
is able to make visible on the display as well the
differences of the chosen dimensions by the
relating latice reproduction ac the input straight
lines as Figures, perhaps beside the calculated planes
which relate to the decay quote of the insulins. The
patient is enabled to make running back the time quan-
tization on the p~nel. The computer can calculatory
dislocate the input triangle base or the exit point of
the loading straigt line for carbon hydrates accor-
3C ding to the resorbtion delay to a later time line.
But actually, the linear functions may be transferred
in such being exponential with increased experience
and further functions may be comprised into the
program processing.
_ 99 _
2164~82
Figure 47 demonstrates in the horizontal or longitudinal
section, and in a natural size (in a lateral rolling-up
of the functional portions), a device for the injecting
of a sensor bIistle into a skin fold. To the left, the
wedge slide for the retreat of the sensor to a scale
2 : 1 is shown. Above, a special configuration of the
sleeve cap is demonstrated, the same below to the
right to a scale of 3 : 1.
The movement runs from the motor axis(53) through the
translating toothed wheels(54) for the reduction of the
velocity on the square axis(627), then through the slid-
ing socket(125) and the square bar(644) to the catching
follower sheet(126) for the turnable slide(127). The
toothed wheel(128) is mounted above the follower sheet
on the square bore and meshes permanently with the pi-
nion(800) by means of jutting and connection disks. The
pinion is shoved along the screw, has lateral naps, and
meshes with the toothed wheel(803), which has, on this
place, only the function to rotate the screw in one di-
rection. The rotation is permanently transferred through
the toothed wheel(802) to the intermediate gear(129) ard
from there to the nut(130).
The sleeve(691) was still maved against the conical bore
in the suction cup(1), and both strong pressure springs
(261,262) were tightened against their four support
columns(854).
The relaxing of the springs is prevented by the bolt
(472) which ccrresponds in construction approximately
to those behind stop knob(270). But the sliding ledge
(134) is depressed with the sinking of the grooved sli-
de(132) by the fork(133). The sliding ledge is fixed
by the stop knob(270) against its tension spring then.
This is possible first then, if the tension spring(235)
is released and depressed on the end of the bcwden cab-
~ 35 le toward the grooved slide. (The small pressure spring
- behind the the stop knob stores the stopping moment).
The leaf spring(136) is in reality turned about 90 de-
- 100 -
,_ 21C4~82
grees around the axis of the groovec' slide and secures
the stability in the height of the latter. The bowden
line(135) between the grooved slide(132) and the wedge
slide(137), again with pawer storing in a spring, ef-
fects the lowering of the latter. (To the left, the lat-
eral view of the slide frame elucidates the function of
the thrust effect toward the collar(139) during its de-
pression). The bowden cable(140) lifts the elastic pis-
ton(91), which bears the sensor bristle and has an exca-
vation for a spherical end of that cable. This happensthrough the central bore in the screw bolt(352) whilst
the folded bellows with high elastic septa between the
fold depressions -into which the sensor bristle is stor-
ed- is compressed.
~5 The enlarged detail above to the left shows, t,hat the
sensor bristle is surrounded by the rubber hose end(92), `~
which itself is surrounded from the sleeve(691) after an
air gap. The sleeve cap(111) projects with inner proiec-
tions through slots in the sleeve(691) toward the rubber
; 20 hc~se end and tolerates a certain pressure, exerted from
the sleeve sufficiently to narrow the channel of the rub-
ber hose end around the sensor bristle with the purpose,
of pushing the latter with high speed through the skin,
which is drawn up into the suction cup(1).
The detail below to the right shows the rubber hase end
; (92)directly laying onto the sleeve(691). The sleeve cap
is downward enlarged and has inside naps which corres~ -
pond to such outside naps on the sleeve(991). The projec-
tior;s which reach through slots below in the sleeve(691)
to the rubber hose end(92) czn be fitted above with ton-
gues to cover the slots against slipping out rubber.
The annular ~leeve(577) goes in a thrust-torsion-device
which effects an axis rotation about of 90 degrees with
the turnable slide(127) after each lowering, and which
respectively brings the pro~jecting tongues(93) in ccntact
either with the grooved slide(132) or with both grooved
slides(94,95) for the release of both strong pressure
springs through the bowden lines(96), of which only one
- 101 -
~ 2 1 6~ 58 2
is shawn(c.p.Fig.48) The thrust-torsion mechanism is more
described in Fig. 0. The sleeve(691) is PUt into the groo-
ve(151) by hand and is drawn away again after consumption.
But the invention aims, of course, toward the fitting of
automatic sleeve or grip change analogously described in
Fig.9 to 36 of the European Patent Application No.0 301
165 (published on Febr.2th.89), though for the vertical
grip or shell storing.
Figure 48 gives a cross or vertical section through the de-
vice according to Fig.47 in the level above, of both bolts(472) and in a natural size. Below the detail of the
bearing of the strong pressure springs(261,262) is shown
on the support columns(472).
The housing wall(16) is there drawn-in and the space for
the battery(255) and the electronic control unit(80) is
nominated. Between the stop knob(270) and the tension
spring(235) the release for the sliding ledge(134) is
positioned with the tension spring for the rapid retreat
of the sensor bristle out of the skin.
For this the fork(133) embraces the bcwden line(138) and
is dislocated by the grooved slide(132). The latter is
shifted, as well as also the grooved slides(94,95) in an-
other switching position, by means of one of the opposite
tangues(93) in both directions, whilst it is taken by
the tongue insertions between the follower sheet(126,
Fig. 1) and the toothed wheel, and whilst the power is
transferred from the electric motor(478) to the pinion
(800) with the shifting of the latter along the screw(801,
Fig. 1). When the toothed wheels(802,803) are reached, the
nut(130) is activated on the sliding screw(352) through
the intermediate gear(129) by the pinion at the time in
opposite direction. The functional operation between left
(=below) and right hand (=above) is:
tightening of the springs(261,262)------>
/<------release of the springs(261,262)
~elaxation of the springs(261,262)---->(switch.over of torsion)
/<-----thrust of the sensor bristle
/----> retreat of the sensor bristl.+shell(69)+torsion
- 102 -
~ 2164~82
- Figure 49 shows in a longitudinal section to a scale of
2 : 1 the sleeve(571) of the thrust-torsion-device with
the hammer(121) for the explication of the switching
over between the particular functional stages A - D.
The sleeve(571) shows the inside of the zig-zag groove in
which a small cross peg of the prolongated sclenoid anchor
or bolt engages and effects a quarter-turn of the sleeve
with each stroke, as far as the solenoid bolt is secured
against rotation. The rotation is transferred over the
coiled spring(l41) ar,d the flank with spherical seat(142)
of the hammer to the latter. The hammer shaft is rect-
an_ular to the right (that is: distal) and is prevented
from rotation in the fixedly mcunted bush(143). In the
demonstrated û-position of the solenoid bolt, there is a
circular cross section or radius inside of the bush(143)
so that the torsion effect can operate. (ûf course, with-
out coiled spring, if the connection between solenoid bolt
and flank with spherical seat is respectively elastic).
The hammer area in both detail images below shows a
mechanical stop sleeve(144) which a~; a half groove stops,
in each case, the rotation over a respective operatinq
member (A - D). For this there is an angled piece with a
passage for the stop sleeve(144) and for the horse-shoe-
like bent around pin(146) with terminal disk for the
biased pressure spring.
The lower image shows, as the cam(147) of the hammer has
lifted the sleeve(144) against its spring, that the
axle rotation is released by the coiled spring(141) yet
tensioned over the sleeve(571) and eventually held in a
permanent pretension). The cam of the hammer meets re-
sistance then on the next positioned sleeve(as 144)
because the latter lightly springs back against the
hammer rotation. Thus the stop mechanism can be found
radially distributed. Below, to the left a cross section
in the level of the four sleeves(144). The stop of the
hammer end for the operating stroke is demonstrated with
the four switching stages A - D.
- 103 -
216q5~2
Figure 50 schematically shows in a longitudinal section a
device for the sucking on of tissue liquid and an even-
tual in~jection of drug fluid through a capillary(106).
This is much enlarged with its sleeve(691). (Mainly, the
latter is additionally shortened). The crosses inside
the wall of the sleeve symbolize the measuring layer
with chemicals which react with substance (as glucose)
in the tissue liquid. The capillary is punched to facili-
tate the afflux of liquid from the subcutaneous space
(not drawn), if the upper syringe piston is pulled. The
valve slide(107) is iust open. When the measurement is
performed (over wires to the measuring instrument, not
shown), the valve slide must be pushed (fine hatching)
and then the piston of the syringe, which is filled with
drug. The supply tube from the valve to the orifice
of the sleeve is drawn with dashed lines.
Figure 51 sho~s the variant of the sleeve for the sensor
bristle relating to a device of Fig.47 and others in a
scale of 4 : 1 in the longitudinal~section ard a breaking
off mechanism for the sensor bristle reaching from the
right up to the left lower half. To the left, a sleeve is
shown, shortened in the length, during the sensor thrust
and quite above to the left, a cross section of the slee-
ve.The sleeve(691) consists of any tongues(152), which are
interraupted by longitudinal gaps, of which only three are
demonstrated. A row of props pIOj ects from each tongue,
which centrally enclose the sensor bristle. The entire
sleeve is covered with a high elastic membrane against
pcllution, which membrane is not shown.
The piston(91~ which is shoved foreward into the sleeve,
conically rises above outwards and it spreads the tonoues
(135) asunder whilst the sensor bristle is pushed fore-
wards. The wedge slides(13~) behind the collar(139) of
the sleeve are spread like a vice in a hinge(not shown).
- 104 -
2164~2
~, .
The proceeding shoot-in of the sensor thread (or bristle)
is activated according to a mechanism as in Fi~q.1 ,2 .
The rubber hose end(92), which accepts the pressure from
the collar of the sleeve(691), is supported against the
support(153). The support ring again can be rotated and
is connected with the frontal slides for the production
of skin folds (respective the suction cup) by means of
the props(154), which are indicated there only weakly as
araloQously described at the cup in relation to the nut
lû (131,130;Fig.47).
The pressure which is stored on the hose end, first nar-
rowes the channel around the sensor bIistle. The electric
tracting solenoid(555) is operated by the electroric con-
trol unit through a contact (not shown) perhaps in front
of the strong pressure spring(261). This is done through
the lever(159), the curved wedge slide(155), which activa-
tes a counter-clockwise sector rotation of the support
ring(153), so tha~ the projections(157) come to be situa~-
ed over the gaps(158) of the support ring and can PasS
through. The passage of the projections can be facilitated
by relating slants in the vertical direction. (Below to
the right, the plan view is shown from below to the bEar-
ing disk on the supporting ring). The sleeve is now pres-
sed against the sleeve cap(111),-and the sensor bristle is
shot through the skin. Before the removal of a sleeve, the
solenoid(555) must be activated for traction. The props
(120), which pro~ject from the skin fold shiver (or the
suction cup), and are shown perhaps too weakly, let the
support ring(158) roll up behind them. The staying bet-
3C~ ween the support ring ard teh props(12Q) is not shown.Inside of the rubber hose end(82), the conducting layers
are indicated white dashed lines which continue in the
wires(84) on both sides and contact there with leaf
springs for a transmission toward the measuring instru-
ment. On the case of the method of the abduction of tis-
sue liquid by a kind of wick, sensor layers would corre-
spond to the white dashed lines, perhaps for the reaction
with the glucose of the tissue liquid.
- 105 -
216~58~
- Figure 52 shows the variant of the introduction of a
sensor bristle according to a bore in natural size in the
longitudinal or horizontal section. Above to the right, the
ccnstruction of the sleeve for the transport of the sensor
bristle drawn out in a scale of 2 : 1 . Below the prefer-
red variant of simplificated sleeve.
The demonstrated stage is that of a sensor bristle which
is drilled under the skin in a suction cup(1). The elec-
trical motor(478) with the translating toothed wheels(54)
10 stands firmly :n the housing bottom (omitted) for that;
the square axis for the driving wheel (233) is slidable
through the latter and connected with one of bath carria-
ges, which itself again run along the (dashed drawn) rails
The power clos~ng runs from the driving wheel(233), which
15 rotates freely, to the elongated toothed wheel on the
screw bolt(352). The latter can be moved away from the
suction cup by rotation inside of the prolongated nut(13û)
and takes with it the sleeve(6~1) in a squeezing seat of
its collar(238~ by means of the squeezing sleeve(238).
The rubber hose end(92) around the sensor bristle is ccm-
pressed, first through cross projections by the sleeve
(691). The inner sleeve(97) around the rubber hclse end is
supported against balls against the sleeve cap(111) and
turns with it, whereby the screwed end of the sensor
bristle pierces the skin.
For the largesi; extent under the skin, the sensor bristle
is mcved through the screw bar(235), which happens inside
of an inner thread of a ]arge toothed wheel which is fix-
ed between the nut(130) and the transverse spar(251),
whereby the screw bar(235) is moved through this transver-
se spar with its end. The related small drive wheel(234)is
driven by a second motor (not shown) or through a ccntrol
gcar from the motor(478). The rapid retreat of the sensor
bristle takes place by influence of both pressure springs
(237) between ~he projecting ledges on the suction cup and
- 106 -
~64~
on the carriaye(236) each, which are twice moved upon arail. This occurs after the bolts(472;c.p.Fig.48,there is
only one shown) is released by a solenoid. (The latter is
also not shown as also the vacuum source is omitted).
The variant of the frontal end of the sleeve(691) shows
the sleeve cap(111) firmly integrated around the suction
cup orifice for the sensor bristle and this, indeed,
with a ball bearing for the inner sleeve(97) which absorb-
es the pressure of the rubber hose end. The rubber hose
lû erd rests on the sleeve(691) with a sudden calibre change,
and rotates with the inner sleeve.
Above to the right, the detail is shown of a preferred
solution between sensor sleeve and suction cup in the sca-
le combinatior of 2 : 1. The rubber hose end(92) is firm-
ly fastened with its one end in and on the sleeve(691).The latter has a fine thread on its end, which works
against that one of the nut(130), whereby both threads
are adjusted one against the other with regard to
their gradient.
An inner thread of the inner sleeve(111), which is a por-
tion of the device, correlates to the outer thread of
the screw bolt(352). The inner sleeve(250) is tightened on
the socket(117!, which projects from the suction cup.
A sealing ring lies also between the inner sleeve and the
sleeve(691). The rubber hose end is compressed during the
rotation of tha sliding screw(352) and likewise rotates
the inner slee~e(250) with the carrugated end of the front
side. The inner sleeve is thereby removed from the suction
cup and thus an extent as the sleeve(691j approaches
the former. In use of the device, the sensor (thread) is
shoved out a certain distance of the inner sleeve by the
screw bar(235). (The problems of the safety covering befo-
re use are omitted: they can be sGlved by the drawing off
of a cap or by an glowing wire loop). The skin (with dash-
- 107 -
216458~
ed-and-dottered line), which already clings to the top
of the sensor thread or bristle in the punched disk(254,
Fig.7) is able to evade to the free thread end first. The
thread end is then thrilled through the skin by the rota-
5 tion with the screw nut(130).
Figure 53 shows the variant of a device for the shooting-in
of a sensor bristle under the skin by means of a pressure
gas thrust, and this is done in a harizontal or lonaitudi-
1~ n~l section to the scale of 3 : 1. Singular images of thestacking sheets are shown above (as detail) in a vertical
CIOSS section, the sensor bristle is beared on those
sheets for a time. The device can be suitably operated
from a C02 pressure oas capsule and can make use of ad-
15 ditional devices, as such are described perhaps in Fig.36,but also already in the European Pat.Appl.Nr. 0 2210
O5(Fig.13,17,19 etc.), mainly in that from Mc Kinnon
which was cited above.
A gas thrust is conveyed out from the pressure gas hose
2~ (893) into the channel of the sleev-e(691) through the
tube into the channel of the sleeve(691). The pressure
beam advances ~he end plate(214, very exaggerated on the
sensor bristle and the latter before itself, wherby the
final plate is not able to pass the narrowness(215) on
the sleeve end.
The clamp(253) which is conically shoved between the col-
lar(139) of the sleeve and likewise a tube, serves for
a gas tightly coupling the conical tube end with the fun-
nel of the sleeve(691). The retreat of the sensor bristle
follows from the tension effect at the sclenoid(555)
which takes plsce over the lever(159) to a ledge on
the carriage(236). The latter is mc,ved along the rail
(252) and in the same. (The way is drawn shortened).
Whilst thereby the wedge ledges(99) are drawn back by the
carriage, the eheets are approached against their spring
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216~582
bcws(85,above in a vertical view) during a pushing off onthe bars(355) such a distance, that the sensor bristle
is embraced in the narrowned channel between the stacking
sheets(86) which are alternatively stringed from above and
from below. Thereby a current derivation occurs from the
su:rface of the sensor bristle. Through the electrical (in-
tegrated) lines (84), the sheets transfer the current by
ccntact of the conducting rings one with other to the
measuring inst.ument. Each of the lines thereby re-
sponds to a contact on one sensor bristle side.The stacked sheet, which is shown to the left, with its
slots(98) for the wedged bars(9g) demonstrates the singu-
lar shape (for the spreading of bcth rows of the stacking
sheets). To the right, representations follow of two adja-
cent sheets in the stage of the wedge bar retreat and af-
ter the introduction of these into the slots(98).
The solenoid(5~5) is switched off again after the metabo-
lism mcasurement, and the carriage(252) returns in the
shown position under the working of the pressure sprinq
(237). The wedge bars thereby spread again the stacking
sheets, so tha~ the sleeve can shoved over the sensor
bristle. (Mainly if the suction is introduced from the iet
pump through the pIessure gas hose(893). A repetition of
the sleeve retreat permits i~s rsmoval for a repIacement
of an unused one.
The chamber(354) arises between the cone for the uptake of
the sleeve in the section cup(1) and the pLnched disk(254).
this chamber is plate-like downwards, and closed by the
suction cup edye. One demonstrates the slightly cembering
of the skin ag~inst the sensor bristle through the open-
ing of the punched plate or disk. The light beam(353) can
be reflected on this small skin bLbble and projected along
(or through) to the related sensor before the shoot-in of
the sensor bristle. The optical skin control is e~sentia-
ly facilitated in this manner because surface irregulari-
ties can also be better detected. (A hair bulb follicle
cculd perhaps not pass the small opening of the punched
p~ate or disk).
- lû9 -
216~582
F;~ur~ 54 S~OWS a natural size in a horizontal or
longitudinal section, a device for measuring purposes in
which the sensor bIistle is shortened to a small double
or sensor cylinder(216), the bottom surface of which has
measurin~ layers each of different sensibility reach for
glucose. The carrier thread (of any aiven material, if
it is solved from the sensor ].ayer for the measurement)
with the sensor cylinder -which is here stacking in the
skin- is drawn very overdimensionally because it has
lG in reality a diameter about of 0,3 mm).
Quite to the right in a scale 4 : 1, the carrier thread,
that is to say the carrier capillary(217), is shown inside
of a measuring guiver. The latter consists of a stationary
basic cylinder(219) and the cap cylinder(218) which is
shoved onto the former, bath armed with laser sources as
photoemitter(580) and photosensor(581, or eventually with
use of light ccnducting fibres with auxiliary lenses and
postponent coupling toward the sensor as schematically
drawn above. The electrical wires (6, each doubled) run to
2~ the measuring device (not shown). The shoot-in device re-
lates perhaps to that which is described in Fig.6, whereby
the sleeve(691) for the bearing of the carrier capillary
or the carrier thread is shortened.
The sleeve(691) is connected with its collar(139) with the
collar of the pressure tube, into which leads the pres-
sure gas hose(8g3), by means of the clamp(253). After the
sensor cylinder is saturated with tissue fluid, the bolt
(472,Fig.1,2)is retreated and the tension spring moves the
sleeve(691) ba~k by means of the carriage(236) on the rails
(252), so that the sensor cylinder leaves the skin and the
suction cup is reventilated. (The suction sources are
again omitted because it is known and anyone used).
The sudden calibre change between the small sensor cylin-
der and carrier prevents the passing through of the
3~ skin; the frame of the cylinder in the end of the carrier
serves for the security against a break off of the cylin-
der.
~ IO
2164582
Below to the left, the dome-like end of a diagnostik
pen with a large carrier with a final small sensor cylin-
der, which can be shot in the skin, after the pen is
pressed against a skin part over resilient soft tissue,
so that the fixation of the pen top occurs in a
trough of skin.
The sensor cylinder can be shot into the skin by oas
pressure or spring and the broad carrier works as a
kind of drawing-pin. The measuring evaluation can be
performed in a device as shown in Fig.7 to the right.
The central beam(108) leads as a laser beam (dottered-
dashed drawn) through the central channel(dashed).
Figure 55 shows below, to the left, the device for an
urine sampling and a metabolism check-up to a scale
about of 1 : 5 . To the right thereof, the detail of the
- lower portion is given to a scale of 1 : 1 . Just above,
the sampling device an over view is given to a scale
of '1: 3, below two stages of the sampling operation
in a detail around the test strip.
The tennis-racket like holding frame(606) -perhaps for
woman- can be sticked througlh under the toilet seat and
can be held by the grip(611). The grip has lateral inser-
tions to be folded down before use. Inside of the frame
a paper sac(616) is attached with a free upper portion
which canbe constricted and thereby closed by a lace
(608). A test strip(614) is inserted through a slot into
the bottom of the sac so that the measuring reactive
layer is able to contact with urin. On the free end of
the test strip outside the sac, a string is fastened
and fixed by an adhesive plaster(609) wh~ gF~ten~g~
the slot. On the erd of the plaster, the string(61û) is
bent in the counterdirection first, and leads then in a
loop(613) which can be hanged on the hook
of the spring balance before the filling of the sac by
urinating. The loop of the lace(608) can be fastened on
the hook of the spring balance before for the asce~tain-
,_ 216~58~
ing the urine weight, which is recorded to the computer,
in particular if the tube(602, below to the left) is at-
tached to the injection device perhaps by clamps(not
shown). After the~alarm which indicates the running up
of the reaction period, the sac is held over the toilet,
the plaster is is rolled and pulled away by tension from
the string. The slot(612) is such a way opened, so that
the sac can be e~.ptied. (Second stage as shown under the
first one). The test strip can be evaluated by the pho-
lG tometer of the iniector after it is stuck in a specialmeasuring casing(not shown).
The cc,mplet view demonstrates the spring(6ûl) of the
tension balance with the sac(616) on the hook.inside of the
the tube(602).
The detail gives a longitudinal section through the cen-
tral pin(617, interrupted and shortened), the hcllow
piston(603) which slides along the central pin ar.d is
fastende with the spring(603), while the central pin is ~ :
stationary above on the tube(602). The sliding spring
2~ (618) renders the weight measurement possibly by using
a kind of Whitestone bridge.
Figure 56 shows a low sugar werning device for the use
at night. This is done below in a longitudinal section,
above through a detail of the measuring drum in a cross
section. The ball(619) is fastened in the center of the
drum(621) by an elastic wire. Four contacts(622) are dis-
tributed around the circumference of the dru~.which is
mcunted in the housing(16). (The latter is buckled on an
ar~ or leg or an other body portion by the belts(623).
With each touching of the ball with one of the four ccn-
tacts(622) on the drum, a current circuitry is closed to
the condensator(625) which is laden over wires (dashed
lines) from the batteries(255). An alarm(628) is activa-
ted from the control unit(80), if the condensator load
- 112 -
216~8~
inside of a destinated period exceeds a regulated meas-
ure.
The influenc~of an increased perspiration causes the cur-
rent amplify between two poles (+/-) on a special Pad
5(629) of fabr-ic which can be taken under consideration
and repulated for the alarm by the user. (Wires or leads
are dashed sketched, the plaster is clapped foreward from
the underside of the housing in reality facing the skin.
The iniector (with its dia~nostic device) might be acti-
l~vated through the leads(631) instead of the alarm.
The invention shall not be narrowed to the given examp-
les, but the claim for protection should be expand to
similar solutions, mainly to combinations bLt with
15 prior mentioned inventive elements. In this manner, a
sin~le slide can be moved against another which re-
meins fixed on the housing. A linear Piston-cylinder
pump can be used for the suction production, instead
of the mounting of a rotary Pump (as such from Wankel
20 type) The skin fold can be raised'also by adhesive
means as shown in Fig.1 of DE P 37 08 031.8. The opera-
t ng functions may be distributed in any manner between
~ors and solenoids. The torcion-push-sleeve can be
multiply its functional staaes from four to five or to
25 any more, if needed, as in the example of Fi~.55.
A multi-functional solenoid could permit the chan~e bet-
ween single an Permanent functions as described in Fig.
9-14 of DE P 37 08 031.8. The examples could be set forth and
should be comprised all inside o~ the claims, which are in
30 the followin~l are set out:
,
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