Note: Descriptions are shown in the official language in which they were submitted.
21C1895
Case 5518
FLAVORED DENTURE CLEANSER COMPOSITIONS
BACKGROUND OF THE INVENTION
sThe aim of a denture c1P~rl~Pr product is to clean the denture as fully and as
quickly as possible and especially to remove the aCcl~mlll~tion of plaque,
agino lS and bacterial deposits which collect while the denture is being worn.
To wear a denture which has not been cOlllpl Ply cleaned of plaque and bacterialdeposits is not only unh~g~laic but can also result in a detrimental effect on the
10mllcous ~ bl~ne within a short period of time. Moreover, deposits can lead to
color change and malodor formation.
Self-cJe~ning denture 5Ie~ e~ ~ offer a convenient method for cleaning
d-,.llul~s. Cleallse,~ in granule or tablet form are dissolved in water to form a
denture clP~nser solution. The dentures are then soaked in this solution for a period
15of time and then rinsed before being reinse,led into the ~earel's mouth. It iscommon, however, that the user of this method will subsequently rinse the dentures
in moulhw~sl, or brush them with or without toothpaste before leinse, lion to impart
a pleasing flavor to the user's mouth. Thelerore a need exists for a flavored denture
cle~n~r which can provide the denture wearer with noticeable flavor benefit after
20their dentures have been cleaned by a solution cle~n~er regimen and avoid the need
for s Ibseq~lPnt short term product use.
It has been discovered that a dry flavor powder system comprising certain
flavors can be h~co",o,aled in a self-cle~ni~ denture cle~n~er composition. It has
also been discovered that this flavored denture cle?n~er composition can deliver2snotic~ble flavor to the denture wearer even after the dentures are cleaned in the
~I~P11~er solution.
It is therefore an object of the invention to provide a flavored denture
c1e~n~r which effectively cleans dentures through so~ing in a cle~n~Pr solution. It
is also an object of the invention to provide a flavored denture cle~n~er composition
30where the flavor survives the rigorous cle~nin~ conditions in the cle~n~çr solution
and delivers noticeable flavor to the denture wearer a~er the cle~nin~ regi,llell.
These and other objects of the present invention will become readily app&,elll
from the det~iled description which follows.
3s
SUMMARY OF THE rNVENTION
2~ 4893
The present invention relates to a flavored denture t~ ncer composition
con.~..ising from about 0.1% to about 50% of a dry flavor powder system
compl;s;llg, by weight of the system, from about 0.01% to about 60% of one or more
40 flavors, and from about 40/O to about 99.99% of one or more carriers; and from
about 50% to about 99.9/O of a denture c~ , and wL~eil1 one or more flavors
delivered by the dry flavor powder system are retained on a denture after cle.~ g
with the flavored denture c~e~nu,- composition. The dry flavor powder system is
incol~oraled in the denture ~I~An~er to provide a denture cle~ncer composition which
4s delivers noticeable flavor to the denture wearer after the dentures are cleaned by
present r1e~nc~r compositions.
DETAII,ED DESCRIPTION OF THE INVENTION
The present invention comprises a dry flavor powder system which is
incorporated in a denture cle~cf~r The invention compositions provide denture
so c~e~ni~ in the form of powders, granules or tablets. The tablets can be in the form
of monolayer tablets or can comprise two or more discrete layers. The invention
compos lions can be dissolved in water to form a denture cleanser solution or
form~ ted as liquids or pastes.
The term "denture" as used herein means all those removable orthodontic
ss appl;s~ees such as partial and full sets of false teeth, dental plates, orthodontic
;~in~.~, andbridges.
The term "ml" as used herein means milliliter.
The term "g" as used herein means gram.
Dry Flavor Powder System
The dry flavor powder system comprises one or more flavor oils or flavor
.-.h.omic~lc incorporated into a dry powder through the use of one or more carriers.
The term carriers, as used herein, means any material suitable for incorporating an oil
or other substance to a dry form. The one or more flavors delivered by the dry flavor
powder system are l~lained on a denture after r1e~ning with the flavored denture6s r1eP-~ r composition. The dry flavor powder system delivers noticeable flavorbenefit to the denture wearer after their dentures have been cleaned by the present
flavored denture c1e~nc~r compositions.
The dry flavor powder system may be formed by any technique applopliate
for incorporating an oil or other subsl~nce in dry powder form. Plerel-ed teçhniques
70 are air-s~lspen~ion cooling, spray-drying, and microen~rsl~tiQn. Such techniques
are generally desclil,ed in Kirk-Othmer~ Encyclopedia of Chemical Technolo~y,
Third Edition, vol. 13 pp. 470-484.
- 21C~895
The dry flavor powder system also comprises various carriers which are used
to il~cG.~Grale one or more flavors to powder conci~tency. Illustrative, but non-
7s limiting materials useful in the present invention as carriers include maltodeYtrin;starch based matrices such as co.,.~larch, cyclodextrin in~ ling aromatics, alcohols,
non-ionic species and aliphatic materials; sugar solids such as mono-, di- and
polysaccharides; and various gums such as gum arabic, gum acacia and guar gum.
Mq1tod~Ytrin is prerelled for use in the present invention. Carriers are used at levels
80 of from about 40% to about 99.99%, pl~;r~lably from about 50% to about 80%, and
most prer~,~bly from about 75% to about 95% by weight of the dry flavor powder
system.
Various flavors can be used in the dry flavor powder system of the present
invention. Illustrative but non limiting examples of such flavors include peppermint
8s such as Mentha piperita; spe&ll"inl such as Mentha cardiaca and Mentha spicata;
other Mentha varieties ~Y~ di~ Mentha arvensis: hydrocarbons such as limonene,
cd yopl.~llene, --y-cene, and h--rmllçne; alcohols such as menthol, linalool, 3-decanol,
and pinocarveol; esters such as nlt;lllllyl acetate, benzyl isobutyrate, and 3-octyl
acetate; ketones such as peperitone, menthone, spicatone, and l-carvone; aldehydes
so such as acetq~ hyde, 3-h~Yqnql or n-octanal; oxides such as menthofuran or
pepertione oxide; acids such as acetic and ocenoic; phenols such as thymol; sulphides
such as dimethyl sulphide; oxides such as carvyl acetate-7,7 oxide; coolants such as
pa ~---c~ Al-e carboxyamide agents, N-ethyl-p-mçnthq-ne-3-carboyqm:1e~ and 3-l-
menth4~y~opalle-1,2-diol; wintergreen; anise; citrus; fruit flavors; rinnq-m~ n;ss e~genQ!; ionone; ~qnetholc; eucalyptol; vanillin; and mixtures thereof.
Pl~;r~lled are ~,-linl, alcohols such as menthol, linalool, 3-decanol, and
pinocarveol; ketones such as peperitone, menthone, spicatone, and l-carvone;
aldehydes such as 3-h.oYvn<q,l; oxides such as menthofuran; phenols such as thymol;
slllrh:1es such as ~l;...e~.ll.y-l sulphide; coolants such as param~nthqne carboxyamide
oo agents, N-ethyl-p-...e..ll.Ane-3-carboxq-mi1e, and 3-l-menthox~.,opane-1,2-diol;
anise; citrus; fruit flavors; ~irmqmon; eugenol; ionone; anethole; eucalyptol; and
mixture thereof. Most plerel,ed are anise, m~nthol, menthone, thymol, ionone,
n~"oll~ and mixtures thereo Pep,oe"""ll such as Mentha piperita, and/or
~ea,ll--lll such as Mentha spicata are most pr~;re"~d when combined with one or
05 more of anise, menthol, menthone, thymol, ionone, çinnqmon, and mixtures thereof.
Flavors are used at levels of from about 0.01% to about 60%, preferably from about
20% to about 50% and most plerelably from about 5% to about 25%, by weight of
the dry flavor powder system.
21C48gS
` -
The dry flavor powder system is used in the present invention at levels of
o from about 0.1% to about 50%, prere.~bly from about 2% to about 40%, and most
preferably from about 5% to about 25%, by weight of the flavored denture cle9n~r
o~ n.
Denture Cleanser
The denture cle~n~r component of the invention compositions conll,-ises a
5 b'e~-hin~ agent, a peroxyacid bleach precursor and a solid base material. Each of
these will be ~ c..ssed further below. The denture rleqn~r is used in the present
invention at levels of from about 50% to about 99.9%, preferably from about 60% to
about 98%, and most plefelably from about 75% to about 95%, by weight of the
~oled denture cle?n~,r composition.
120 The bl~aching agent takes the form of the inorganic persalt and can be
s~lected from any of the well-known bleachi~ agents known for use in denture
cle~ such as the alkali metal and an-ll.ol~ium perslllf~tçs~ perborates,
pe.c~l,onates and perphosphqtes and the alkali metal and alkaline earth metal
peroxides. Illustrative, non-limiting examples of such ble~chin~ agents include
pot~ m ammonium, sodium and lithium persulfates and perborate mono- and
tetrahydrates, sodium pyrophosphate peroxyhydrate and m~l~s~ C~lci~
strontium, and zinc peroxides. Plefelled are alkali metal pers~lf~tçs~ pe-l,olates and
~lules thereo
The amount of bleA~hin~ agent in the denture rle~n~er composition is
generally from about S% to about 70%, and preferably from about 10% to about
50/0. In compositions comprising a mixture of alkali metal persulfates and
perborates, the overall persulfate:perborate ratio is suitably from about 5:1 to about
1:5, and preferably from about 2:1 to about 1:2.
The organic peroxyacid precursor can be generally defined as a compound
135 having a titre of at least 1.5ml of 0. lN sodium thios~lf~te in the following peracid
formulation test.
A test so! ltion is pl~parèd by dissolving the following materials in 1000 mls
di~tilled water:
Sodium pyrophosphate 2.5g
Sodium perborate 0.615g
(having 10.4% available oxygen)
Sodium dodecylh~n7~one sulphonate 0.5g
To this solution at 60C an amount of activator is added such that for each
atom of available oxygen present one molecular equivalent of activator is introduced.
216~895
The mixture obtained by addition of the activator is vigorously stirred and
~ ed at 60C. Mer S m~ ltes from addition, a lOOml portion of the solution is
withdrawn and imme-liqtely pipcUed onto a mixture of 250g cracked ice and 15ml
glacial acetic acid. Pot~c~;~lm iodide (0.4g) is then added and the liberated iodine is
;--...-~Ai~lPIy titrated with O.lN sodium th:cls~lrh~te with starch as indi~tor until first
50 d;sappf~ance ofthe blue color. The amount of sodium thiosulphate solution used in
ml is the titre of the bleach activator.
The organic peracid precursors are typically compounds Co~ p. one or
more acyl groups, which are ~sceplible to pelhydrolysis. The prcre"cd activatorsare those of the N-acyl or O-acyl compound type cQ~IA~ np an acyl radical R-CO
55 wllclcill R is a hydrocarbon or sub~tituted hydrocarbon group having prerer~bly from
about 1 to about 20 carbon atoms. Examples of suitable peracid precursors include:
1) Acyl or~noAm;des of the formula RCONR1R2, where RCO is a
carboxylic acyl radical, Rl is an acyl radical and R2 is an organic radical, as disclosed
in U.S. 3,117,148. FYAmples of compounds falling under this group include: N,N-
60 diacetylaniline and N-acetylphthqlim:1ç; N-acylhydantoins such as N,N'-diacetyl-5,5-
d",.~,ll,ylhy l~ntoin; polyacylated alkylene ~iz~;nf s such as N,N,N'N'-
tel~&cctylethylene~ mine (NTAED") and the corresponding methylenf,~i~mine
(nTAMD") and kf.. rthylçne~iqmi-le ("TAHD") derivatives; acylated glycolurils
such as tcl, ~cetylglycoluril.
16s 2) Acylated s~lphon~mi~les such as N-methyl-N-ben_oyl-mf nthqne
sulphonal~"de and N-phenyl-N-acetyl ..,~ e sulphonamide.
3) Carboxylic esters such as phenyl acetate, sodium acetoxy benzene
s~lrh~natç, tricloroctl,~ et~tç, sorbitol hf~Y~Get~te, fructose pçnt~^cet~te, p-nitrobfn7~ldçhyde ~iacetqte, isopropencyl acetate, acetyl aceto hydlo~ullic acid and
70 acetyl salicylic acid and esters of a phenol or s~lbstituted phenol with an alpha-
chlorinated lower aliphatic carboxylic acid such as chloroacetylphenol and
chloroacetylsalicylic acid.
4) Calllo~ylic esters having the general formula AcL wherein Ac is the acyl
moiety of an organic carboxylic acid comprising an optionally substit~lte~ linear or
75 I~ ched C6-C20 alkyl or alkenyl moiety or a C6-C20 alkyl-substituted aryl moiety
and L is a leaving group, the co~ug~te acid of which has a pKa in the range from 4
to 13, for e ~le oxyl,e~-7f e,.llfonate or oxyb~ ~.o~le. ~Icr~cd compounds of
this type are those wherein:
a) Ac is R3-CO and R3 is a linear or branched alkyl group
180 co.. l~ g from 6 to 20, preferably 6 to 12, more prcfc,ably 7 to 9 carbon
atoms and wherein the longest linear alkyl chain çYtçn~ing from and inc~
216489~
the carbonyl carbon co~ c from 5 to 18,p,ere~bly from 5 to 10 carbon
atoms, R3 optionally being slbstitl~ted (preferably alpha to the ca-l,onyl
moiety) by Cl, Br, OCH3 or OC2Hs. Examples of this class of material
include sodium 3,5,5-lli-"e~ rlhexanoylu~benzene sulfonate, sodium 3,5,5-
l~il".,~ lhexanoyloxyben-zoate, sodium 2-ethylhexanoyl ox~il,el~ene-
sulfonate, sodium nonanoyl oxy-benzene sulfonate and sodium octanoyl
o"yb~n,e~-es~lffinate, the acyloxy group in each in.ct~nce preferably being p-
substitute~1;
b) Ac has the formula R3(AO)mXA wherein R3is a linear or
b,~ched alkyl or alkylaryl group conl~ ing from 6 to 20, preferably from 6
to 15 carbon atoms in the alkyl moiety, R5 being optionally substituted by Cl,
Br, OCH3 or OC2Hs, AO is o~y~;~l-ylene or o~yl lO~ ylene, m is from 0 to
100, X is O, NR4 or CO-NR4, and A is CO, CO-CO, R6-CO, CO-R6-CO or
CO-NR4-R6-CO ~hereil~R4is C1-C4 alkyl and R6 is alkylene, alkenylene,
arylene or alkarylene co~ il-g from 1 to 8 carbon atoms in the alkylene or
alkenylene moiety. Bleach activator compounds of this type include carbonic
acid derivatives of the formula R3(AO)mOCOL, succinic acid derivatives of
the formula R3OCO(CH2)2COL, glycollic acid derivatives of the formula
200 R30CH2COL, h~droAy~,.opionic acid derivatives of the formula
R3OCH2CH2COL, oxalic acid derivatives of the formula R30COCOL,
maleic and fumaric acid derivatives of the formula R30COCH=CHCOL, acyl
aminocaproic acid derivatives of the formula R3CONRl(CH2)6COL, acyl
glycine derivatives of the formula R3CONRlCH2COL, and amino-6-
20s o~Yos~rroic acid derivatiws of the formula R3N~Rl)CO(CH2)4COL. In the
above, m is preferably from 0 to 10, and R3is preferably C6-C12, more
prefe~;~ly C6-Clo alkyl when m is zero and Cg-Cls when m is non-zero.
The leaving group Lis as defined above.
5) Acyl-cyanurates, such as triacetyl- or tribenzoylcyanurates, as disclosed
210 in US Patent No. 3,332,882.
6) Optionally substituted anhydrides of benzoic or phthalic acid, for
~mp1e benzoic anhydride, m-chlorobenzoic anydride and phthalic anhydride.
Of all the above, pfere.-ed are organic peracid precursors of types l(c) and
4(a).
215 The level of peroA~ cid bleach precursor by weight of the denture cle~n.~or
c~mrosition is prere.ably from about 0.1% to about 10%, more preferably from
about 0.5% to about 5%.
-- 21C189~
_
The solid base material and, in plt:rt:"ed embotiim~ntc~ the bleach precursor
ag~ e.ales also incol~o~ale an effervescence generator. The effervesc~-nce
220 generator utilized in the compositions herein can be s~lected from generators which
are effective under acid, neutral or allcaline pH conditions, but p-ert,ably it consists
of a combil alion of a g,el e.~tor which is effective or most effective under acid or
neutral pH conditions and a generator which is effective or most effective underalkaline pH conditions. Effervescence gene,~lo-s which are effective under acid or
225 neutral pH conditions include a col"binalion of at least one alkali metal carbonate or
bic&ll,onale, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate,
potassium ca,l~onate, potassium bicarbonate, or mixtures thereof, in a~lmixh1re with
at least one non-toxic, physiologically-accepta~le organic acid, such as tartaric,
fumaric, citric, malic, maleic, gluconic, succinic, salicylic, adipic or sulphamic acid,
230 sodium fumarate, sodium or poPcsillm acid phosphates, betaine hydrochloride or
ixlures thereof. Malic acid is p.er~" ed.
Effervescence generators which are effective under alkaline pH conditions
include persalts such as alkali and alkaline earth metal peroxoborates as well as
pelbolales~ persulphates, perca,l.onàles, perphosphates and mixtures thereo An
235 ~A~UIIple of such effer~escence generators in~ des a mixture of an alkali metal
perborate (anl,~d,ous, mono- or tetrahydrate) with a monopersulphate such as
Caroat~ marketed by E I DuPont de Nemours Co. and which is a 2:1:1 mixture of
,..ollope~ lphate, potassium sulphate and potassium bisulphate and which has an
active oxygen content of about 4.5%.
240 In highly prefe"ed compositions, the solid base material incorporates both a
(bi)cd~lJol1d~e/acid effervescent couple and a perborate/persulphate oxygen
effervescçn~e generator while the bleach precursor agglomerates incorporate a
(bi)~a l,onale/acid and optionally a peroxoborate oxygen effervescence generator.
The coml)inâlion of generators is important for achieving optimum ~iicsol~ltion
245 characteristics and pH conditions for gene,~tion of the peroxyacid bleach and for
achieving optimum ele~ ng and a,lti",icrobial activity. The (bi)carbonate
co",pol1e,lls generally comprise from about 5% to about 65%, plt;r~l~bly &om about
25% to 55% of the denture r1eAn~r composition; the acid components generally
co",p,ise from about 5% to about 50%, preferably from about 10% to about 30% of
250 the denture cleAllcer composition.
In pre~"~;d embo~iments herein, the inorganic ble?clling agent comprises an
alkali metal pe,l,orate and the solid base material comprises at least one co",ponent
phase having an acid or neutral pH in aqueous merii~-m; said at least one phase having
incollJota~e therein at least a portion ofthe alkali metal perborate.
-' 21648g5
~_ 8
2ss For optil.lunl ~ntip~^q~le and Antihacterial pt;.ro"llal~ce, the cle~nQi~
co",pos;lion is preferably dç.signed in such a way that the bleach precursor
agglo---e.ates dissolve or dispelse in water more slowly or later than the acid or
neutral phase in order to provide, on placing the cleAnin~ composition in water, an
initial pH in the acid or neutral range, p~ererably from about 2 to about 7.5 and
260 preferably from about 5 to about 7. Moreover, it is prerelled that the bleach
precursor agglomerates have an alkaline pH in aqueous medi~m and be present in
~fficient amount in order to shift, upon CG .~letion of effervescence, the pH of the
nqueous ...e~ .. into the alkaline range, preferably to a pH of from about 8 to about
10, this pH being prerellt;d for reasons of cleAnin~ pelro~-lallce and solution clarity.
26s The initial acid or neutral pH should be ~ A;I-çd for a time from about 30 second
to about 5 minlltes~ preferably from about 1 minute to about 3 minlltes
Efferve3ce~ce is preferably co pleted in from about 30 seconds to about 4 minl~tes
preferably from about 1 to about 3 minlltes of the pH being shifted into the alkaline
range.
270 The slower r~i~colutiQn rate of the bleach precursor agglomerates conlpaled
with the tablet matrix base material can be achieved in various ways, for example, by
the use of alkaline salts or compounds which are inherently sparingly or slowly
soluble such as al~,~dr~lls sodium c~l,onale, calcium carbonate, calcium hydroxide,
n~a~.es: .... oxide, or mqgnçQ;~Im hydroxide carbonate or by mixing or comp-es~il-g
27s the bleach pre;u,~r Aeglomerate co"lpollellls with a filler which has a slow.liQ-Q~lution rate such as anhydrous sodium sulfate and slowly water-soluble polymers,
for example, proteins, ce~ lose ethers, cellulose esters, polyvinyl alcohol, alginic acid
esters, vegetable fatty pselldocolloidal character. Moreover, the relative rate of
dissolution ofthe bleach precursor agglomerates and tablet matrix can be additionally
280 controlled by applupl;ale formulation and distribution of the binding/agglol,lt;l~lil~
and effervescent components of the solid base material and bleach precursor
agglomerate.
In another embodiment of the invention which is plerelled from the view
point of providing more rapid tablet dissolution, the inorgal~ic bl~ac1ling agent
28s comprises an alkali metal perborate and the solid base material comprising at least
one component phase having an alkaline pH in aqueous me~ m with at least one
phase having incoll,o,aled therein at least a portion of the alkali metal perborate.
For optimum CleAn;~P. pelro""al-ce, the bleach precursor agglomerates in this
emho~limçnt plertlably have an acidic or neutral pH in aqueous ~.,e~ " and
290 ~ itionqlly incorporate an agglo~.~e.aling agent and an effervescçnce generator.
Overall, for optimum di~.solllti~n, stability, and pe,ro",.ance, the bleach ple~u-~or
216~8g5
-
a~glQInerates and the solid base material preferably have a pH dirrerence in aqueous
".P1;...~ of from about 0.5 to about 2 pH units. The level of bleach precursor
ag~lo...e.~es is plere.~bly from about 1% to about 20%, and more preferably from29sabout 5% to about 15%, by weight ofthe C1~An~ g tablet.
The bleach pr~;ut~or a~lomerates prt;r~lled for use herein generally
comprise a binder or agglol"t;,aling agent in a level of from about 1% to about 40%,
more especially from about 10% to about 30% by weight of the denture c1eA-l.cer.Sl-it-b'e A~lomerating agents include polyvinylpyrrolidone, poly(oxyethelen) of
300moleclllAr weight 20,000 to 500,000, polyethyleneglycols of molecular weight of
from about 1000 to about 50,000, Carbowax having a molecular weight of from
4000 to 20,000, nonionic surfActAntc fatty acids, sodium carboxymethyl cellulose,
gelatin, fatty alcohols, phosphAtes and polyphosphates, clays, Al~minosilicates and
polymeric polycarboxylates. Of the above, polyethyleneglycols are highly prere"ed,
30sçspeçiAlly those having a molecular weight of from about 1,000 to about 20,000.
~lere"ed from the viewpont of optimum dissolution and pH characteristics
are bleach precursor agglomerates which comprise from about 10% to about 75%,
pler~lably from about 20% to about 60% by weight thereof of peroxyacid bleach
precursor; from about 5% to about 60%, preferably from about 5% to about 50%,
310more preferably from about 10% to about 40% of a (bi)carbonate/acid effervescent
couple; from about 0% to about 20% of a peroxoborate; and from about 5% to
about 40%, preferably from about 10% to about 30% of an agglo"lt;. dLi~lg agent.The final bleach precursor granules desirably have a particle density
(individual particle basis) of at least 1.05 g/cc and an average particle size of from
315about 500 to about 1500, preferably from about 800 to about 1200 um, this being
valuable from the viewpont of optimum dissolution pe~ro"..ance and aesthetics.
The compositions of the invention can be supplcm~nted by other usual
components of ç1~An~ e table formulations, especially surfActA-ntc ch~l~tin~ agents,
e~ es, ~ tu~, sweeteners, tablet binders such as the above specified bleach
320 precursor agglo...e.aling agents, especiAlly polyethyleneglycols having a molecular
weight of from about 12,000 to about 30,000, foam deplessa--ls such as
dill..,ll.ylpolysiloxanes, foam stabilizers such as the fatty acid sugar esters,p,~,se-~ali~es, lubricants such as talc, m~n~sillm stearate, finely divided amorphous
pyrogenic silicas, etc. The free moisture content of the denture cle~n.cer composition
32s is desirably less than about 1% and especially less than about 0.5%.
The surface active agent used in the compositions of the invention can be
s~ ed from the many available that are co-,-palible with the other ingredients of the
denture ~le~nce ~ both in the dry state and in solution. Such materials are believed to
2164895
- 10
improve the effectiveness of the other ingredients of the cGn-pGsit;on by aiding their
330 pe~ .alion into the interdental surfaces. Also, these materials aid in the removal of
food debris ~ttnched to the teeth. Between 0.1 and 5 percent by weight of the dry
c~lll~s.lion of a dry powder or grandular anionic surface active agent, such as
sodium lauryl sulfate, sodium N-lauroylsarcos;rl-s~te, sodium lauryl sulfonretste or
dioctyl sodium sulfosucçinste or ricinoleyl sodium sulfos~lGçinsite, may, for example,
33s be inrl~lded in the colllpo3;tion and preferably the surface active agent col"p,;ses
b~ n 2 and 4 percent ofthe composition.
Suitable cationic, non-ionic and ampholytic surface active agents incl~lde, for
~A~I_rl~, quaternary a~.. on: lm compounds such as cetyltrimethyla"l"lonium
bromide, conden~stio~ products or alkylene oxides such as ethylene or propylene
340 oxide with fatty alcohols, phçnQle fatty amines or fatty acid alkanol~m;dçs, the fatty
acid alkanol amides themselves, esters of long-chained (Cg-C22) fatty acids withpolyalcohols or sugars, for eA~Il~;lc, glycerylmonostearate or saccharosemonolaurate
or sorbitolpolyoAy~lllylen~monQ- or di-stearate, be~ e sulphobelailles or long-
chain alkyla,l,h~ocall,uAyl;c acids.
34s Ch~l~ting agents bçnefiri~lly aid rleqnin~ and bleach stability by keeping
metal ions, such as c~lcil-m, mqgn~ei~lm and heavy metal cations in solution.
F.Y~mr~s of suitnl?le çhel~ting agents include sodium tripolyphosphate, sodium acid
pyrophosph~te, tetr~eo~illm pyrophosphate, an~nopolycarboxylates, such as
nitrilotriacetic acid and ethylçne~ mine tetracetic acid and salts thereof, and
3so polyphosphonates and ~I~.nopolyphosphon~tes such as hyd~oAyelhql-edirhosphonic
acid, ethylen~~ e t~ ~lL~lenephosphc - ~ acid, diethylenet,;~ epçnt~-
methylenephosphQnic acid and salts thereof. The chel~ting agent selected is not
critical except that it must be co,l"~alil,le with the other ingredients of the denture
when in the dry state and in aqueous solution. Advantageously, the
355 c~ -p. agent col"p,ises between 0.1% and 60% by weight of the denture Cle~ne~r
and pr~r~,~bly betv~een 0.5% and 30%. Phosphonic acid chPl~tinp. agents, however,
preferably comprise from about 0.1% to about 5%, prere,ably from about 0.1% to
about 0.5% by weight ofthe denture cle~n~r.
Enzymes suitable for use herein are exemplified by proteases, ~ ee
360 a"yld~s, lipases, dcAlland5e5, mn~ ceQ ~I--c~n~eee, etc.
A prerel-ed embodiment of the denture rle~ncer encompqeses a cle~n
tablet coll")-ising visually discrete agglomerated particles of an organic peroxyacid
bleach precursor dispersed in a water-soluble or water-dispersible matrix comprising
an inOI~alliC persalt bl~achin~ agent and a solid base material which in the presel~ce
365 of water releases carbon dioxide or oxygen with effervescçnce. Other embodirn~nts
216l895
include the cle~n~er compositions described in U.S. Patent 5,055,305, to Young,
issued 10/8/91, which is incorporated herein by ~e~lence.
The following ey~rnr~es further describes an embodiment within the scope of
the present invention. These examples are given solely for the purpose of illustration
370 and are not to be construed as a limit~tion of the present invention as many variations
thereof are possible without departing from the spirit and scope of the present
invention. Pel~ ~t~ges are by weight unless otherwise stated.
EXAMPLE I
Denture Cleanser Mixture Weight %
37s Malic acid 13.97
Sodium bicarbonate 24.69
Sodium carbonate 6.45
Pot~ m l-,ollopel~.llphate 12.90
Sodium perborate 16.45
380 EDTA(a) 1.55
Polyethylene glycol 20000 6.66
Polyethyleneglycol 10000 1.55
SDBS(b) 0.55
DRMS(C) 0.27
38s Wasag 7(d) 0.09
Wasag 15(e) o 09
Silica 1.39
Syloid 0 35
Sodium carbonate 3.71
390 Sulphamic acid 1.89
TAED(f) 3.87
Color mix 1.45
Dry Powder Flavor System(g) 2.12
Flavors Dry Weight %
3ss Menthol 62.5
Anise 31.25
Ionone 6.25
(a) Ethylenedi~ netetraacetic acid
400 (b) Sodium dodecyl ben7Pnesulfonate
(c) Diasodium riçino'~midQ monoeth~nolamine sulfosuc~in~te
(d) 70% Sucrose P~lmit~te/30% Sucrose Stearate
216~895
-
12
(e) 70% Sucrose Stearate/30% Sucrose P~lrnit~te
(f) Tetraacetylethylene ~i~n ine
405 (g) Spray dried flavors (20% flavor loaded, 80% m~ltodeYtrin)
EX~MPLE II
Denture Cleanser Mixture Weight %
Malic acid 13.97
410 Sodium bic~ e 24.69
Sodium cd,bona1e 6.45
Potassium monopc,~ulphate 12.90
Sodium pe~bo,~te 16.45
EDTA(a)
415 Polyethylene glycol 20000 6.66
Polyethylene glycol 10000 1.55
SDE~S(b) 0.55
DRMS(C) 0.27
Wasag 7(d) o 09
420 Wasag 15(e) 0.09
Silica 1.39
Syloid 0.35
Sodium carbonate 3.71
Slllrh~mic acid 1.89
425 TAED(f) 3.87
Color mix 1.45
Dry Powder Flavor System(g) 2.12
Flavors Dry Weight %
Menthol 40.0
430 Peppe~"linl 20.0
Cinnamon 20.0
Anise 40.0
(a) Ethylene~;h...;.-eletraaceticacid
435 (b) Sodium dodecyl ~e ~ne~lJlfonate
(c) Diasodium ricinoleamido monoetll~nolamine sulfosucçin~te
(d) 70% Sucrose p~lnnit~te~30% Sucrose Stearate
(e) 700/o Sucrose Stearate/30% Sucrose P~lmit~te
(f) Tetraacetylethylene rli~1nin~
~lC48gS
13
440 (g) Spray dried flavors (20% flavor loaded, 80% maltodextrin)
F-Y~n1P'eS I and II may be made as follows: Mix toge~hPr applo,.;~lely 3.04
~ams of denture cle~n~r mixture and 0.32 grams dry flavor powder system. In a
clean receptacle, place appro~;...~ttoly lSOml water and the flavored denture cle~n~.r
..u~lure. Stir or shake and place denture in solution for at least 20 mimltes. Rinse
44s with tap water and insert in mouth.
