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(12) Patent Application: | (11) CA 2258965 |
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(54) English Title: | USEFUL FORMULATIONS OF ACID ADDITION SALT DRUGS |
(54) French Title: | FORMULES UTILES DE MEDICAMENTS COMPORTANT DES SELS D'ADDITION D'ACIDES |
Status: | Deemed Abandoned and Beyond the Period of Reinstatement - Pending Response to Notice of Disregarded Communication |
(51) International Patent Classification (IPC): |
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(72) Inventors : |
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(73) Owners : |
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(71) Applicants : |
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(74) Agent: | CASSAN MACLEAN |
(74) Associate agent: | |
(45) Issued: | |
(86) PCT Filing Date: | 1997-06-23 |
(87) Open to Public Inspection: | 1998-01-08 |
Examination requested: | 2002-06-11 |
Availability of licence: | N/A |
Dedicated to the Public: | N/A |
(25) Language of filing: | English |
Patent Cooperation Treaty (PCT): | Yes |
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(86) PCT Filing Number: | PCT/US1997/010829 |
(87) International Publication Number: | US1997010829 |
(85) National Entry: | 1998-12-22 |
(30) Application Priority Data: | ||||||
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Methods of and formulations for administering acid addition salts of compounds
of Formula (A) or Formula (B), wherein R1 comprises an aryl or alkyl group
with a hydrogen bond acceptor site accessible to interaction with said
tertiary nitrogen of Formula (A) or said quaternary ammonium ion of Formula
(B), R2, R3 and R4 are alkyl or aryl groups, and X- is an anion. In the
methods, a sterile injectable formulation of a liquid vehicle containing the
acid addition salt in solution is adjusted in pH for reducing the development
of undesirable side effects of the material or provided at a pH within a range
of about 5.5 to 7.0, and administering these acid addition salts by
intramuscular injection contain the salt at a concentration of at least about
50 mg/ml and are at a pH within a range of about 5.5 to 7Ø
L'invention porte sur des procédés et préparations servant à l'administration de sels d'addition d'acides de formule (A) ou (B) dans lesquelles: R¿1? consiste en un groupe aryle ou alkyle comportant un site accepteur à liaison hydrogène accessible à des interactions avec ledit azote tertiaire de formule (A) ou ledit ion ammonium quaternaire de formule (B); R¿2?, R¿3? et R¿4? sont des groupes aryle ou alkyle; et X?-¿ est un anion. Le procédé consiste à ajuster le pH d'une préparation injectable stérile comprenant un véhicule liquide contenant une solution de sel d'addition d'acides afin de diminuer le développement d'effets secondaires non souhaités de la substance, ou à amener ladite préparation à un pH compris environ entre 5,5 et 7,0, puis à administrer les sels d'addition d'acides par injection intramusculaire les contenant à une concentration d'au moins 50 mg/l, et dont le pH est compris environ entre 5,5 et 7,0.
Note: Claims are shown in the official language in which they were submitted.
Note: Descriptions are shown in the official language in which they were submitted.
2024-08-01:As part of the Next Generation Patents (NGP) transition, the Canadian Patents Database (CPD) now contains a more detailed Event History, which replicates the Event Log of our new back-office solution.
Please note that "Inactive:" events refers to events no longer in use in our new back-office solution.
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Description | Date |
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Inactive: IPC from MCD | 2006-03-12 |
Inactive: IPC from MCD | 2006-03-12 |
Inactive: IPC from MCD | 2006-03-12 |
Inactive: IPC from MCD | 2006-03-12 |
Inactive: IPC from MCD | 2006-03-12 |
Inactive: IPC from MCD | 2006-03-12 |
Time Limit for Reversal Expired | 2004-06-23 |
Application Not Reinstated by Deadline | 2004-06-23 |
Deemed Abandoned - Failure to Respond to Maintenance Fee Notice | 2003-06-23 |
Letter Sent | 2002-07-17 |
All Requirements for Examination Determined Compliant | 2002-06-11 |
Request for Examination Received | 2002-06-11 |
Request for Examination Requirements Determined Compliant | 2002-06-11 |
Inactive: Applicant deleted | 1999-04-15 |
Classification Modified | 1999-03-16 |
Inactive: First IPC assigned | 1999-03-16 |
Inactive: IPC assigned | 1999-03-16 |
Inactive: IPC assigned | 1999-03-16 |
Inactive: Filing certificate correction | 1999-02-26 |
Inactive: Correspondence - Transfer | 1999-02-26 |
Inactive: Notice - National entry - No RFE | 1999-02-18 |
Application Received - PCT | 1999-02-15 |
Application Published (Open to Public Inspection) | 1998-01-08 |
Abandonment Date | Reason | Reinstatement Date |
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2003-06-23 |
The last payment was received on 2002-05-14
Note : If the full payment has not been received on or before the date indicated, a further fee may be required which may be one of the following
Patent fees are adjusted on the 1st of January every year. The amounts above are the current amounts if received by December 31 of the current year.
Please refer to the CIPO
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Fee Type | Anniversary Year | Due Date | Paid Date |
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Basic national fee - small | 1998-12-22 | ||
Registration of a document | 1999-01-27 | ||
MF (application, 2nd anniv.) - small | 02 | 1999-06-23 | 1999-06-11 |
MF (application, 3rd anniv.) - small | 03 | 2000-06-23 | 2000-06-22 |
MF (application, 4th anniv.) - small | 04 | 2001-06-26 | 2001-06-20 |
MF (application, 5th anniv.) - standard | 05 | 2002-06-24 | 2002-05-14 |
Request for examination - standard | 2002-06-11 |
Note: Records showing the ownership history in alphabetical order.
Current Owners on Record |
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OXIGENE, INC. |
OXIGENE, INC. |
Past Owners on Record |
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RONALD W. PERO |