Note: Descriptions are shown in the official language in which they were submitted.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
1
COMPOSITION FOR AROMA DELIVERY
_
FIELD
The present invention relates generally to a composition for delivering
aroma. More particularly, the present invention relates to a composition for
aroma delivery that is generated by an exothermic reaction.
BACKGROUND
Aromatic volatile components have been widely used in variety of
products, including pharmaceutical products. Certain types of aromatic
volatile
components (e.g., menthol, eucalyptus oil, camphor, thymol) are known for
treatment and therapy of common colds to relieve congestion and blocked nose.
Many consumers suffering from colds or allergies and having some associated
symptoms, for example, blocked nose and cough, tend to use pharmaceutical
products made with such aromatic volatile components. These pharmaceutical
products are commonly used by inhaling aroma vapours along with water
vapours to relieve blocked nose, cough, and other cold or allergy symptoms.
Generally, the vapours are generated by using hot water or steam.
Recently, another usage of aromatic volatile components has become
increasingly popular. Consumers with mental stress often prefer to be in
perfumed environments as a way to decrease stress. Due to their ability to
induce relaxation and relief of mental stress, certain aromatic volatile
components have become popular for treatment and therapy of such stress.
These aromatic volatile components (e.g., cineol, jasmine, lavender oil) are
known for providing fragranced environments in aroma therapy, as aromatic
fragrance components. Herein, "aroma therapy" refers to a therapy which is for
mental treatment, getting away from or releasing stress and, inducing
relaxation,
especially to ease mental stress. A conventional aroma therapy is by an
CA 02325037 2000-09-20
WO 99/48469 PCTNS98/05581
z
inhalation of aroma vapours. Aroma is generated from the aromatic fragrance
components by using hot water in combination with aromatic actives, or by
heating a vessel, for example a pot or a plate, in which aromatic fragrance
ingredients and water are placed. Consumers, however, tend to become
frustrated with such methods of use, i.e., heating water for aroma vapours
and/or
steam inhalation, and with cleaning messy vessels due to oily or waxy bases
used for aroma generation after the inhalation of aroma vapours.
Certain exothermic reactions have been previously used for the purpose
of generating heat or increasing temperature. A variety of products using
exothermic reactions are known, for example, in food products (e.g., self-
heating
meal modules, see Taub et al. U.S. Patent 5,517,981), pharmaceutical products
(e.g., body warmers, see Sahara, U.S. Patent 5,220,909), or smoking articles
(e.g., cigarette, see Potter et al. U.S. Patent 4,955,399}.
Based on the foregoing, there is a need for a composition for aroma
delivery that is convenient and readily usable, and which provides pleasant
and/or therapeutic aromatic vapours by using an exothermic reaction.
SUMMARY
The present invention is directed to a composition for aroma delivery
comprising: (a) an aromatic ingredient; (b) an exothermic ingredient; and (c)
a
pH adjusting agent; wherein the aroma is delivered when water is added to the
composition.
The present invention further relates to a composition for aroma delivery
comprising: (a) an aromatic ingredient selected from the group consisting of
an
aromatic active, an aromatic fragrance ingredient, and mixtures thereof; (b)
first
granules comprising an exothermic ingredient and a first carrier; and (c) a
second granules comprising a pH adjusting agent and a second carrier; wherein
the aroma is delivered when water is added to the composition.
These and other features, aspects, and advantages of the present
invention will become better understood from a reading of the present
disclosure.
DETAILED DESCRIPTION
While the specification concludes with claims particularly pointing out and
distinctly claiming the invention, it is believed that the present invention
will be
better understood from the following description.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
3
All percentages and ratios used hereinafter are by weight of total
composition, unless otherwise indicated.
All measurements referred to herein are made at 25°C unless
otherwise
specified.
All percentages, ratios, and levels of ingredients referred to herein are
based on the actual amount of the ingredient, and do not include solvents,
fillers,
or other materials with which the ingredient may be combined as a commercially
available product, unless otherwise indicated.
All publications, patent applications, and issued patents mentioned herein
are hereby incorporated in their entirety by reference. Citation of any
reference
is not an admission regarding any determination as to its availability as
prior art
to the claimed invention.
"Comprising" means that other steps and other components which do not
affect the end result can be added. This term encompasses the terms
"consisting of and "consisting essentially of."
The present invention relates to a composition for aroma delivery
comprising: (a) an aromatic ingredient; (b) an exothermic ingredient; and (c)
a
pH adjusting agent; wherein the aroma is delivered when water is added to the
composition.
Preferably, the temperature generated by the reaction of the exothermic
ingredients with water is in the range of from about 40°C to about
100°C, more
preferably from about 40°C to about 70°C. The specified
temperature generated
is achieved by the combination of the exothermic ingredients and water.
Without
being bound by theory, it is believed that such temperature range is suitable
for
volatilizing aromatic ingredients including an aromatic active compound, and
an
aromatic fragrance compound.
fn a preferred embodiment, the composition can deliver aroma by steam
which may be generated by the temperature increase resulting from on the
exothermic reaction with water.
A. Aromatic ingiredient
The composition of the present invention comprises an aromatic
ingredient. "Aromatic ingredient" herein refers to an ingredient which
volatilizes
due to the temperature generated by the reaction of the exothermic ingredients
with water, and delivers aroma to the user. The aromatic ingredients useful in
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
4
the present invention include an aromatic active ingredient, an aromatic
fragrance ingredient, and mixtures thereof.
The aromatic ingredient may be provided in any form, for example as an
oil or as a water-oil emulsion. For example, in one embodiment, a kit product
using the method of the present invention has two chambers, wherein one
chamber contains an aromatic ingredient in emulsion, and another chamber
contains an exothermic ingredient and a pH adjusting agent.
"Aromatic active ingredient" herein means an ingredient which is specially
used for a medical therapy. The aromatic active ingredient can include any
ingredients which are conventionally used as actives for medical treatment,
for
example, various aromatic actives which may be volatile and useful for
treatment
of colds, allergy symptoms, and blocked nose in various over-the-counter
products. These aromatic actives can be in solid or liquid form.
Nonlimiting examples of the aromatic active ingredient include menthol,
eucalyptus oil, camphor, thymol, turpentine oil, I-desoxyephedrine, bornyl
acetate, and mixtures thereof.
"Aromatic fragrance ingredient" herein means an ingredient useful in
aroma therapy for mental relaxation. Exemplary of the aromatic fragrance
ingredients of the present invention include peppermint oil, spearmint oil,
lavender oil, citronella oil, lemon oil, orange oil, sandalwood oil, and
mixtures
thereof.
In certain embodiments, the aromatic active ingredient may further provide
preferable fragrance in addition to the vapours for medical treatment purpose.
B. Exothermic ingredients
The composition of the present invention comprises an exothermic
ingredient. "Exothermic ingredient" herein means an ingredient which is used
for
a reaction, called an exothermic reaction, to generate heat on reaction with
water. The exothermic ingredients useful in the present invention can be any
ingredients which are conventionally used for generating heat on reaction with
water, and are available for use in pharmaceutical areas. The exothermic
ingredients useful herein include a metal or a metal oxide.
The metals of the present invention include, for example, magnesium and
sodium, preferably magnesium. The preferred metal oxides herein are calcium
oxide.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
Mechanisms of the exothermic reaction using metals differ from the
reaction using metal oxides. Theoretically, the exothermic reaction of metal
with
water requires the presence of an acidic medium. The mechanism of the metal
based exothermic reaction is that one mole of metal reacts with two moles of
5 water in the presence of hydrogen ion, thereby one mole of metal hydroxide
is
derived, with the heat generation enabling volatilization of the aromatic
ingredients. The following is an example of the exothermic reaction of the
present invention using metal as the exothermic ingredient.
M + 2H2O H M(OH)2 + H2 I + Heat (I)
As shown above, the exothermic reaction (I) using metal with water
derives a metal hydroxide with evolution of hydrogen gas. The hydrogen gas is
evolved as bubbles and tends to give effervescence, leading to improve
aesthetics. It is believed that the hydrogen gas may help the delivery of
aroma
and give a signal to the user as to the progress of the reaction of the
exothermic
ingredients with water. At the time when the exothermic reaction is
substantially
completed, the amount of bubbles evolved decreases.
The quantity of water added based on the exothermic reaction (I) is from
about 1:20 to about 1:100, preferably 1:20 to 1:50 to the ratio of metal by
weight
for generating the temperature appropriate to volatilize the aromatic
ingredients.
For example, a composition for delivering aroma including about 0.1gm of metal
is prepared and by adding about 5 ml (mgs) of water, a maximum temperature of
about 68 degC. is generated for volatilizing the aromatic ingredients.
Preferably, the metal is of a high purity, and particularly when the aroma
delivery in limited to occur using a large scale exothermic reaction (e.g.,.
four
times the amounts of metal and of water shown in the examples herein, as may
be useful for providing aroma delivery in a room). It is believed that large
scale
exothermic reactions, particularly the reaction using magnesium, may cause off
odor or less odor reaction when the metal is of insufficient purity.
When metal oxide is the choice for the exothermic reaction to deliver
aroma in the present invention, one mole of water is needed for the reaction
with
one mole of the metal oxide. In this case, there is no need for the presence
of
acids such as hydrogen ion for the exothermic reaction. As in the case of
reaction (I), one mole of a metal hydroxide is derived, with the appropriate
CA 02325037 2000-09-20
WO 99/48469 PCTNS98105581
6
temperature generation to volatilize the aromatic ingredients. The following
is an
example of the exothermic reaction using metal oxide.
MO + H20 --- M(OH)2 + Heat (II)
No gas is evolved by the reaction (II). However, for giving the same
aesthetic bubble effect as the hydrogen gas generated by the reaction (I}, the
exothermic reaction using metal oxide may include an effervescent agent.
The quantity of metal oxide to water based on the exothermic reaction (II}
is at least from about 1:2 to about 1:15 by weight, preferably from about 1:2
to
about 1:5, for generating the temperature for volatilization of the aromatic
ingredients. For example, a composition for delivering aroma including about
1gms of metal oxide is prepared and by adding about 5 ml (mgs) of water, a
maximum temperature of about fi7 degC. is generated for volatizing the
aromatic
ingredients.
C. aH adjusting aaent
Herein, "pH adjusting agent" means a component which is useful for
neutralization of the metal hydroxide derived by the exothermic reaction of
the
present invention described by reactions (I) and (II). It is recognized that
these
metal hydroxides derived from the exothermic ingredients with water tend to
provide an undesirable alkaline pH condition, probably a pH of more than about
10. Generally, such pH condition is not safe. Therefore the pH adjusting agent
is added to neutralize the metal hydroxides generated during the reaction. The
following is a reaction for neutralization.
M(OH)2 + R-COOH -- RCO-OM (lit)
The pH adjusting agent useful herein includes any of the acids used for
conventional neutralizations. Exemplary of the pH adjusting agent herein are
citric acid, oxalic acid, and tartaric acid.
The pH adjusting agent can be added such that the conditions of the
composition after aroma delivery are slightly acidic, preferably a pH of from
about
3 to about 7. Total amount of the pH adjusting agent to the exothermic
ingredients herein may be in the ratio from about 1: 3 to about 1: 6 by weight
of
the composition. When metal is used as the exothermic ingredient, the weight
ratio of the metal to the pH adjusting agent is preferably at least about 1 :
6.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
7
When metal oxide is the exothermic ingredient, preferably the pH adjusting
agent
is at least about 1 : 3 by weight ratio.
D. Additional ingredients
The composition of the present invention can further comprise additional
S ingredients selected from the group consisting of a carrier, a effervescent
agent,
a binding agent, a coloring agent, a tableting aid, and mixtures thereof. In
embodiments comprising tablet, powder, or granules, the additional ingredients
are preferably in a solid form to facilitate operating flowability and product
stability.
The additional ingredients must be of sufficiently high purity and of
sufficiently low toxicity to obtain the desirable quality for aroma delivery.
Additional ingredients other than described below that are useful for the
present
invention further include, for example, diluents such as glucose, mannitol and
directly compressible sugar; stabilizing agents such as agar, pectin, gums and
starches; antioxidants such as ascorbic acid and BHA; preservatives such as
potassium sorbate and sodium benzoate, and the like; as well as other non-
toxic
compatible substances used in pharmaceutical formulation.
1. Effervescent agent
The composition of the present invention, especially those using the
exothermic reaction (I) to vaporize aromatic ingredients, can evolve gases as
discussed above. However reaction (II) does not provide bubbles, but
sometimes it may be desirable to have bubbles, for example, for aesthetic
purposes. "Effervescent agent" herein means any carbonate salt that provides
bubbles when reacted with acid. Generally, the effervescence is evolved by the
reaction of a carbonate source with an acidic source, for example, in the
combination of a carbonate salt and a carboxylic acid. Any ingredients which
would be useful conventionally as an effervescent agent in the pharmaceutical
area may be acceptable herein. The effervescent agent of the present invention
can be selected depending upon compatibility with other components,
particularly
the pH adjusting agent which reacts with the effervescent agent. The preferred
effervescent agent herein is sodium hydrogencarbonate. The following is one
embodiment of the reaction using sodium hydrogencarbonate with citric acids as
acidic sources.
NaHC03 + Citric Acid -- Na-Citrate + C02 ~ (IV)
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
8
The carbon dioxide is evolved by the reaction (IV) to provide
effervescence.
2. Carrier
The compositions of the present invention, especially those which are in
tablet form, may include a carrier. The carrier useful for the compositions
herein
can be any which is available and conventionally used in pharmaceutical
compositions. The carrier can be selected depending upon the compatibility
with
all of the ingredients included as well as the desired characteristic of the
composition. Preferably, the carrier suitable herein is sugar.
The carrier may be added in a variety of forms depending on the form of
the composition, preferably the carrier in solid form. For example, when the
composition is in tablet form, the carrier may be mixed with other ingredients
such as the exothermic ingredient and the pH adjusting ingredient during
granulation.
The carrier is present at an effective level, preferably at a level of from
about 10% to about 70% by weight of the composition. Preferably, the carrier
may be added to each of main ingredients such as the exothermic ingredient and
the pH adjusting agent separately for making granules to facilitate the
process of
tableting (e.g., granules containing the exothermic ingredient and the
carrier;
granules containing the pH adjusting agent and the carrier.) Preferably, the
ratio
of such ingredients to the carrier is about 50:50.
3. Binding agent
The compositions for the present invention may also include a binding
agent. Inclusion of a binding agent is particularly useful to bind the
components
used for tablet forms of the composition. It is believed that insufficiencies
in
binding ability tend to cause compositions in tablet form, and especially
those
having a disc type shape, to break off into two pieces along the diameter
during
the manufacturing process. This splitting of the tablet is commonly referred
to as
"capping." The levels and types of binding agent are selected depending upon
compatibility with other components, and desired characteristic of the final
product.
Examples of useful binding agents include sugar, sugar alcohols, starches
such as starch paste and pregelatinized starch, polyvinylpyrrolidone,
cellulose
derivatives, gelatin, gums, and mixtures thereof. In certain embodiments,
especially the tablets, the binding agent and the carrier may be made of the
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
9
same material. Alternatively, the binding agent and the carrier may be
altogether
different. It is believed that the binding agent contributes to stability of
the
granules when added in the process of making granules.
The binding agents may be present in an effective amount, preferably
from about 0.1 % to about 10% by weight, more preferably from about 0.5% _to
about 3%.
4. Coloring agent
The composition including the method of the present invention may further
include a coloring agent. The coloring agent may be present at an effective
level, preferably from about 10 ppm to about 500 ppm, more preferably from
about 20 ppm to about 250 ppm by weight.
5. Tabletingi aids
When the composition of the present invention is in tablet form, tableting
aids can be added in order to facilitate forming the tablets. Herein,
"tableting
aids" refers to an ingredient that is added to the granules in small
quantities to
improve flowability to the granules, to reduce friction, and/or to ease
removal of
the tablets from the tableting machine. The tableting aids useful herein
include,
for example, magnesium stearate, stearic acid, aerosol, talc, and mixtures
thereof. The tableting aid of the compositions of the present invention, is
preferably present in an amount sufficient to prevent the tablet from breaking
into
two pieces, preferably from about 0.1 % to about 8%, by weight of the tablet.
E. Granulation
Preferably, the composition of the present invention can be provided as a
mixture of granules, especially the compositions in tablet form. Such
compositions prepared from the granules and compressed the granules into
tablet tend to generate suitable temperature for aroma delivery, thereby
provide
pleasant aromatic vapours.
Generally, granules can be handled readily during manufacturing. For
example, granules provide an uniform mixture and distribution of ingredients
into
the composition, and facilitate the compression of ingredients into tablets.
Due to
the uniform distribution of ingredients, the composition herein produced by
granules tends to contact with water effectively for causing the exothermic
reaction to generate the desirable temperature and deliver the aromatic
ingredient.
CA 02325037 2000-09-20
WO 99/48469 PCTNS98/05581
The composition of the present invention can comprise mixtures of
granules. Especially useful are mixtures of granules comprising a carrier with
the
exothermic ingredient or a carrier with the pH adjusting agent.
First granules are obtained from the exothermic ingredients combined with
5 a first carrier. The ratio of the first carrier to the exothermic ingredient
is from
about 30:70 to about 70:30, preferably 50:50 by the weight of the first
granules. w
Second granules are prepared by combining the pH adjusting agent with a
second carrier. The ratio of the second carrier to the pH adjusting agent is
from
about 30:70 to about 70:30, preferably 50:50 by the weight of the second
10 granules.
The first carrier and the second carrier, which are used for the first and the
second granules, can be the same carrier or different carriers. When the
composition includes one carrier, the carrier may be proportionally included
in the
first granules and in the second granules. When the composition include more
1 S than one carrier, each carrier may be separately added to the first and
the
second granules, or may be premixed and then proportionally included in each
of
the first and the second granules.
The granules herein may further include a binding agent. The binding
agent can be the ~ same as those discussed above or may be different
ingredients. It is believed that inclusion of certain binding agents may cause
the
temperature generated by the reaction to be somewhat lower, because of slow
dissolution of the composition. The levels and types of the binding agent are
selected depending upon the character of the carriers, compatibility with
other
components, and desirable characteristic of the final products.
METHOD FOR MAKING COMPOSITION
The compositions of the present invention can be produced by any
method useful for forming compositions, e.g., tea bag, powder, or tablets, in
pharmaceutical or food industries known in the art. Such conventional methods
for making powder, granules, or tablets include direct compression of
ingredients
and a preparation of granules before compression when the products is in
tablets
form.
The granulating methods useful herein include wet and dry granulating
method, preferably wet granulating. Depending on the properties of the
ingredients (e.g., active ingredients, carriers, flavors, coloring agents, and
the
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
11
like) to be formulated into granules, one method may provide a more favorable
end product over the other method. The wet granulation method is widely used
and usually produces the most satisfactory results in tablets. See E.J. de
Jong;
"The preparation of microgranulates, an improved tableting technique,"
Pharmaceutical Weekblad, 104(23), pages 469-474, 1969 and E.J. de Jong, U.S.
Patent 3,266,992.
The tablet forms of the compositions of the present invention also can be
made by any method which is conventionally used for tableting. Preferably, the
tableting method includes preparation of granules by the wet granulating
method
as described above. See, for example, Palermo, et al., U.S. Patent 3,384,546.
Direct compression may also be chosen for the present composition, as long as
producing tablets does not cause capping.
USE OF THE COMPOSITION
The composition of the present invention can be used for a variety of
products in different areas, including pharmaceutical products. These products
are, for example, pharmaceuticals for medical treatment of physical injuries
and
as aroma therapy products for inducing relaxation and stress release by being
in
perfumed environments. The perfumed conditions provided are also useful for
skin treatment. The composition of the present invention may further be used
for
pest control, by generating a certain toxin. The compositions are particularly
useful for readily inhalation of aromatic actives and fragrance compounds for
treatment of symptoms such as cold, blocked nose, and the like.
The composition of the present invention may further be suitable for
products designed for body warming, including for example, heating or warming
pads to warm the body to enable it to release pain. The composition herein may
useful to lessen the stress caused by such pains, at the time of treating the
injury
by warming the painful areas of the body.
The composition of the present invention may further be suitable for a kit
product, for example, a kit comprising two chambers wherein one chamber
contains water and the other contains the composition. Such a kit is used by
removing a separator located between two chambers which keeps the
composition from reacting with water until the kit is used. Alternatively, a
kit
including a bag into which the composition is packed may be provided, the bag
being made from a water-impermeable material such as polymer. Such a kit is
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
12
used by breaking the bag in the presence of water. Any form of the composition
may be provided in the kit.
In other embodiment of a kit, the kit comprises an effective amount of an
aromatic ingredient in a first chamber, an exothermic ingredient and a pH
adjusting agent in a second chamber, and water in a third chamber, wherein the
second chamber is next to the third chamber, such that, upon combining the
second chamber and the third chamber, an exothermic reaction is generated
and aroma is delivered. Such kits are also useful as products mentioned above.
The composition of the present invention take a variety of forms
depending on its usage. These formations can include tablet, powder or
granules, and those suitable for packed into bags or containing into kits.
Preferably, the form is tablet.
Tablet is a typical pharmaceutical form which is easy and convenient to
use. The composition of the present invention can be compressed into the
tablet form. The tablet is used as follows: put the tablet in a cup into which
water
is contained so that the exothermic reaction proceeds and the aroma is
delivered. Without being bound by theory, it is believed that due to the
limited
surface areas of the tablet form, the rate of the exothermic reaction tends to
be
slow at first, probably until the tablet is dissolved, after which the time
the
exothermic reaction proceeds more efficiently and generation of aroma suddenly
becomes harder than previous. Prior to that time, most of the reaction may
occur only on the surface of the tablet. The tablet composition in tablet form
tends to provide a peak temperature, about 2 minutes after contact with water,
although that time depends on the diameter, thickness, and/or hardness of the
tablet. After achieving a peak temperature, the heat generation by the
exothermic reaction is decreased, then the temperature cools down. It is
believed that the most of the surface of the tablet start disintegrating, the
rate of
reaction becomes faster than before, resulting in sudden increase of the heat
generation leading to a peak temperature. Generally, at temperatures of less
than about 40 degC., the aroma delivery may not be generated or there may be
a lesser generation of aroma.
Powder or granules are another embodiment of the composition. The use
of the powder form composition or granules is same as the tablet; put the
powder or granules into a cup in which water is contained or added later,
thereby
the aroma is delivered. It is believed that due to the higher surface area of
the
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
73
powder form of the composition versus the tablets form of the composition, the
rate of reaction is faster than that of the tablet composition and can deliver
aroma more uniformly, i.e., the temperature versus time profile is flat with
no
peak. In addition, the temperature generated by the reaction of the powder
form
composition or granules may be lower than the that of tablet form.
EXAMPLES
The following examples further describe and demonstrate embodiments
within the scope of the present invention. The examples are given solely for
the
purpose of illustration and are not to be construed as limitations of the
present
invention, as many variations thereof are possible without departing from the
spirit and scope of the invention.
The components shown below can be prepared by any conventional
method well known in the art. A suitable method and formulation are as
follows:
Example I A tea bag composition 1
23.54gms of calcium oxide as an exothermic ingredient, 71.86gms of
Citric acid as a pH adjusting agent, 3.1 gm of menthol as an aromatic active
and
1.5 gm of spearmint oil as an aromatic fragrance are mixed in a V cone blender
about 30 min at 30 RPM. 5 gm of the mixture I is packed in a tea bag made from
paper (tea bag 1 ).
Example )< A tea bag composition 2
13.06 gm of magnesium as an exothermic ingredient, 78.36 gm of Citric
acid as a pH adjusting agent, 7.36 gm of menthol as an aromatic active and
1.22
gm of spearmint oil as an aromatic fragrance are mixed in a V cone blender
about 30 min at 30 RPM. 1 gm of the mixture II is packed in a tea bag made
from paper (tea bag 2.)
Example ~f A powder composition 1
23.54 gm of calcium oxide as an exothermic ingredient, 70.61gm of Citric
acid as a pH adjusting agent, 3.1 gm of menthol as an aromatic active and 1.5
gm of spearmint oil as an aromatic fragrance, and 1.25 gm of NaHC03 for an
effervescent effect {to generate C02 gas) are blended in a V cone blender and
mixed about 30 min at 30 RPM.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
14
Example N A powder composition 2
13.06 gm of magnesium as an exothermic ingredient, 78.36 gm of Citric
acid as a pH adjusting agent, 7.36 gm of menthol as an aromatic active, and
1.22
gm of spearmint oil as an aromatic fragrance are blended in a V cone blender
and mixed about 30 min at 30 RPM.
Example V A tablet composition 1
79.83 gm of 1:1 Citric acid - Sugar -granules, 13.3 gm 1:1 Magnesium
Sugar granules, and a mixture containing 2.5 gm of aerosil, 3.75 gm of menthol
as aromatic active and 0.63 gm of spearmint oil as a aromatic fragrance is
prepared.
The mixture of aerosil, menthol and spearmint oil is added to a Kalweka
{made by Cadmac, India) in which the Sugar - Citric acid granules, Magnesium
Citric acid granules are then mixed for 20 minutes at 30 RPM.
The resulting granules are compressed on single punch machine (made
by Cadmac, India) into a tablet having a diameter of 19mm.
(Wt%~
Example Example Example Example
I >( )Q 1V Example
V
product type tea bag tea ba~ powder
1 1 powder tablet
2 1
calcium oxide 23.54 - 23.54 - -
magnesium - 13.06 - 13.06 -
Mg-granules - - - - 13.3
NaHC03 - - 1.25 - -
Citric acid 71.86 78.36 70.61 78.36 -
Citric-granules - - - - 79.82
Menthol 3.1 7.36 3.1 7.36 3.75
Spearmint oil 1.5 1.22 1.5 1.22 0.63
Aerosil - - - - 2.5
Total 100.0 100.0 100.0 100.0 100.0
Mg-granules containing 1:1 of magnesium and sugar.
Citric-granules containing 1:1 of citric acid and sugar.
CA 02325037 2000-09-20
WO 99/48469 PCT/US98/05581
The embodiments disclosed and represented by the previous examples
have many advantages. For example, they can provide effective aroma delivery
that is both aesthetically and/or therapeutically desirable and convenient to
use.
It is understood that the foregoing detailed description of examples and
5 embodiments of the present invention are given merely by way of
illustration, and
that numerous modifications and variations may become apparent to those
skilled in the art without departing from the spirit and scope of the
invention; and
such apparent modifications and variations are to be included in the scope of
the
appended claims.
