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(12) Patent: | (11) CA 2472561 |
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(54) English Title: | PROCESS FOR THE PRODUCTION OF DRONABINOL |
(54) French Title: | PROCEDE DE PREPARATION DE DRONABINOL |
Status: | Term Expired - Post Grant Beyond Limit |
(51) International Patent Classification (IPC): |
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(72) Inventors : |
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(73) Owners : |
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(71) Applicants : |
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(74) Agent: | GOWLING WLG (CANADA) LLP |
(74) Associate agent: | |
(45) Issued: | 2010-11-02 |
(86) PCT Filing Date: | 2002-02-05 |
(87) Open to Public Inspection: | 2002-08-15 |
Examination requested: | 2007-02-01 |
Availability of licence: | N/A |
Dedicated to the Public: | N/A |
(25) Language of filing: | English |
Patent Cooperation Treaty (PCT): | Yes |
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(86) PCT Filing Number: | PCT/EP2002/001172 |
(87) International Publication Number: | EP2002001172 |
(85) National Entry: | 2004-02-16 |
(30) Application Priority Data: | ||||||
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A method for the production of dronabinol is disclosed, whereby: a)
cannabidiol is isolated from fibrous hemp as cannabidiol acid, b) the
cannabidiol, optionally obtained by decarboxylation, is cyclised in the
presence of Lewis acids in a non-polar solvent to give dronabinol, c) the
above is isolated by a chromatographic method and d) the residue obtained from
the eluant after distilling off the solvent is purified by vacuum
distillation. The dronabinol can be used for dispensing purposes in a syringe
filled therewith and as inhalation solution for thermal nebulisation with hot
air.
Procédé de préparation de dronabinol qui consiste (a) à isoler du cannabidiol sous forme d'acide de cannabidiol à partir de chanvre indien, (b) éventuellement à cycliser le cannabidiol obtenu par décarboxylation en présence d'acides de Lewis dans un solvant non polaire pour obtenir du dronabinol, (c) à isoler ce dernier par un procédé chromatographique et (d) à purifier par distillation sous vide le résidu obtenu à partir de l'éluat, après élimination du solvant par distillation. Le dronabinol peut par ex. être utilisé, pour des préparations pharmaceutiques, dans une seringue remplie de ladite matière, et en tant que solution d'inhalation, par nébulisation thermique à l'aide d'air chaud.
Note: Claims are shown in the official language in which they were submitted.
Note: Descriptions are shown in the official language in which they were submitted.
Sorry, the representative drawing for patent document number 2472561 was not found.
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Description | Date |
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Inactive: Expired (new Act pat) | 2022-02-07 |
Inactive: Correction request denied - Correspondence sent | 2021-01-12 |
Inactive: Correction request denied by analyst | 2021-01-12 |
Appointment of Agent Requirements Determined Compliant | 2020-02-25 |
Inactive: Office letter | 2020-02-25 |
Inactive: Office letter | 2020-02-25 |
Revocation of Agent Requirements Determined Compliant | 2020-02-25 |
Appointment of Agent Request | 2020-02-19 |
Inactive: Patent correction requested-Formalities | 2020-02-19 |
Revocation of Agent Request | 2020-02-19 |
Change of Address or Method of Correspondence Request Received | 2020-02-19 |
Common Representative Appointed | 2019-10-30 |
Common Representative Appointed | 2019-10-30 |
Letter Sent | 2014-09-03 |
Inactive: Single transfer | 2014-08-26 |
Grant by Issuance | 2010-11-02 |
Inactive: Cover page published | 2010-11-01 |
Pre-grant | 2010-08-17 |
Inactive: Final fee received | 2010-08-17 |
Notice of Allowance is Issued | 2010-04-19 |
Notice of Allowance is Issued | 2010-04-19 |
4 | 2010-04-19 |
Letter Sent | 2010-04-19 |
Inactive: Approved for allowance (AFA) | 2010-03-31 |
Amendment Received - Voluntary Amendment | 2009-11-16 |
Inactive: S.30(2) Rules - Examiner requisition | 2009-05-28 |
Amendment Received - Voluntary Amendment | 2008-12-05 |
Inactive: S.30(2) Rules - Examiner requisition | 2008-07-14 |
Letter Sent | 2007-02-13 |
All Requirements for Examination Determined Compliant | 2007-02-01 |
Request for Examination Requirements Determined Compliant | 2007-02-01 |
Request for Examination Received | 2007-02-01 |
Inactive: IPC from MCD | 2006-03-12 |
Inactive: Cover page published | 2004-08-16 |
Inactive: First IPC assigned | 2004-08-11 |
Inactive: Notice - National entry - No RFE | 2004-08-11 |
Inactive: Inventor deleted | 2004-08-11 |
Application Received - PCT | 2004-08-05 |
Inactive: IPRP received | 2004-02-17 |
National Entry Requirements Determined Compliant | 2004-02-16 |
Small Entity Declaration Determined Compliant | 2004-02-16 |
National Entry Requirements Determined Compliant | 2004-02-16 |
Application Published (Open to Public Inspection) | 2002-08-15 |
There is no abandonment history.
The last payment was received on 2009-10-14
Note : If the full payment has not been received on or before the date indicated, a further fee may be required which may be one of the following
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Please refer to the CIPO
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Note: Records showing the ownership history in alphabetical order.
Current Owners on Record |
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THC PHARM THE HEALTH CONCEPT GMBH |
Past Owners on Record |
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CHRISTIAN STEUP |