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(12) Patent: | (11) CA 2617000 |
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(54) English Title: | METHODS FOR PREPARING NEVIRAPINE HEMIHYDRATE AND AN AQUEOUS SUSPENSION THEREOF |
(54) French Title: | METHODES POUR LA PREPARATION D'HEMIHYDRATE DE NEVIRAPINE ET UNE SUSPENSION AQUEUSE CONNEXE |
Status: | Expired and beyond the Period of Reversal |
(51) International Patent Classification (IPC): |
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(72) Inventors : |
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(73) Owners : |
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(71) Applicants : |
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(74) Agent: | SMART & BIGGAR LP |
(74) Associate agent: | |
(45) Issued: | 2011-02-15 |
(22) Filed Date: | 1998-08-11 |
(41) Open to Public Inspection: | 1999-03-04 |
Examination requested: | 2008-01-31 |
Availability of licence: | N/A |
Dedicated to the Public: | N/A |
(25) Language of filing: | English |
Patent Cooperation Treaty (PCT): | No |
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(30) Application Priority Data: | ||||||
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The invention relates to a method for preparing nevirapine hemihydrate and a method for preparing an aqueous suspension of nevirapine hemihydrate. The method for preparing nevirapine hemihydrate which method comprises the steps of: (a) treating an aqueous suspension of anhydrous nevirapine with a strong acid, to yield a solution of the acid addition salt; (b) treating the solution of the acid addition salt produced in the previous step with a strong base, to yield the free base of nevirapine as a precipitate, in the hemihydrate form; and, (c) separating the precipitated nevirapine hemihydrate from the aqueous medium by filtration; and, (d) washing the precipitated nevirapine hemihydrate produced in the previous step with water.
L'invention concerne une méthode permettant de préparer de l'hémihydrate de névirapine et une méthode permettant de préparer une suspension aqueuse d'hémihydrate de névirapine. La méthode permettant de préparer de l'hémihydrate de névirapine comporte les étapes suivantes : a) traitement d'une suspension aqueuse de névirapine anhydre au moyen d'un acide fort pour produire une solution contenant le sel d'addition acide; b) traitement de ladite solution contenant le sel d'addition acide au moyen d'une base forte pour produire la base libre de la névirapine sous forme de précipité hémihydraté; c) séparation de l'hémihydrate de névirapine précipité du milieu aqueux par filtration; et d) rinçage à l'eau de l'hémihydrate de névirapine précipité obtenu à l'étape précédente.
Note: Claims are shown in the official language in which they were submitted.
Note: Descriptions are shown in the official language in which they were submitted.
Sorry, the representative drawing for patent document number 2617000 was not found.
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Description | Date |
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Time Limit for Reversal Expired | 2016-08-11 |
Letter Sent | 2015-08-11 |
Grant by Issuance | 2011-02-15 |
Inactive: Cover page published | 2011-02-14 |
Inactive: Final fee received | 2010-12-02 |
Pre-grant | 2010-12-02 |
Notice of Allowance is Issued | 2010-06-09 |
Letter Sent | 2010-06-09 |
4 | 2010-06-09 |
Notice of Allowance is Issued | 2010-06-09 |
Inactive: Approved for allowance (AFA) | 2010-06-07 |
Amendment Received - Voluntary Amendment | 2010-05-19 |
Inactive: S.30(2) Rules - Examiner requisition | 2009-11-19 |
Inactive: Office letter | 2008-04-22 |
Inactive: Cover page published | 2008-04-18 |
Inactive: IPC assigned | 2008-04-17 |
Inactive: IPC assigned | 2008-04-17 |
Inactive: First IPC assigned | 2008-04-17 |
Inactive: IPC assigned | 2008-04-17 |
Letter sent | 2008-02-26 |
Divisional Requirements Determined Compliant | 2008-02-18 |
Letter Sent | 2008-02-18 |
Application Received - Regular National | 2008-02-18 |
Application Received - Divisional | 2008-01-31 |
Request for Examination Requirements Determined Compliant | 2008-01-31 |
All Requirements for Examination Determined Compliant | 2008-01-31 |
Application Published (Open to Public Inspection) | 1999-03-04 |
There is no abandonment history.
The last payment was received on 2010-07-23
Note : If the full payment has not been received on or before the date indicated, a further fee may be required which may be one of the following
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Note: Records showing the ownership history in alphabetical order.
Current Owners on Record |
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BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. |
Past Owners on Record |
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AMALE A. HAWI |
KARL GEORG GROZINGER |