Note: Descriptions are shown in the official language in which they were submitted.
Tittle:
Black seeds hair growth and re-growth along with other benefits of body.
Description:
Background:
Today world is suffering from many diseases, some of them are uncurable.
Cancer, aids
and other viruses kill many people every year. Black seed can help cure many
diseases.
Hair growth and regrowth is also a dilemma in todays world. Loosing hair makes
one
feel uncomplete and appearance without hair is downgraded individual in
society.
The oils in black seeds and thymoquinone (TQ) extracted from it are effective
against
many diseases in body. The ingredients in black seed can cure or heal body
from
multiple diseases like cancer, cardiovascular diseases, diabetes, asthma,
kidney,
cancer in blood system, lung, liver, prostate, breast, cervix, skin etc. TQ
has
antioxidants that have ability to improve body's defense system, influence
apoptosis
and Akt pathway.
The covenants and attributes of black seed include: According to Iranian
Journal of
Basic Medical Science at Mashhad University of Medical Science. A paper was
written
by Fatemeh Forouzanfar, Bibi Sedigheh Fazly Bazzaz and Hosseinzadeh in year
2014
on extensive study of black seed showing chemical black seed's constituents
32% - 40% fixed oil.
Fatty acids having arachidonic, eicosadienoic, linolenic, oleic, palmitoleic,
palmitic, stearic, and mydriatic acid, betasitasterol, cycloeucalenol,
cycloartenol, sterol esters and sterolglucomsides.
Volatile oil (.4%-.45%)
saturated fatty acids having: nigellone it is carbonyl fraction of oil,
thymoquinone
(TQ), thymohydroquinone (THQ), dithymoquinone, thymol, carvacrol, a and b-
.
pinene, d-limonene, d-citronellol, p-cymene. Also contains: p-cymene,
caravacrol, t-anethole, 4-terpineoI and longifolene.
Black seed have 2 forms of alkaloids: lsoquinoline alkaloid includes:
nigellicimine
and nigellicimine n-oxide. Payrazol alkaloid includes nigellidine and
nigellicine.
The nutritional composition are vitamins, carbohydrates, mineral elements,
fats
and proteins that include 8 or 9 essential amino acids. By sodium dedecyl
sulfate
polyacrylamide electrophoresis (SDSPAGE). The fractionation of whole black
seeds was done which shows the band range from 94 to 100 KDA molecules
mass. Black seed also have saponin and alpha hederine and in trace amount has
carvone, limonene and citronellol. It also provides good number of vitamins
and
minerals such as Fe, Ca, K, Zn, P, Cu (3, 4).
Pharmacological effects of N. sativa seeds such as antioxidant, anti-tussive,
gastroprotective, anti-anxiety, anti-ulcer, anti-asthmatic, anti-cancer, anti-
inflammatory, immunomodulatory and anti-tumor properties, hepatoprotective
CA 3030306 2019-07-15
effect, also gastric ulcer healing, tumor growth suppression, men infertility
improvement, cardiovascular disorders, memory improvement, stimulate milk
production, protective effects on lipid peroxidation, antibacterial activity,
anti
dermatophyte, antiviral activity against cytomegalovirus, have been reported
for
black seed.
Black seed's covenants and especially thymoquinone (TQ) posse's abilities to
be anti-
oxidant, anti-inflammatory, anti-cancer, anti-bacterial and anti-fungal, anti-
carcinogenic, anti-schistosomiasis, anti-viral, anti-parasitic and anti-
mutagenic, (TQ) is
also considered safe for body. In addition, it is anti-tumor and is effective
in cancer
treatment in body. For example, it is effective in the diminishing the risk of
atherosclerosis by decreasing the serum low density lipoprotein cholesterol
level and
increasing the serum high density lipoprotein cholesterol levels (Dahri et
al., 2005;
Nader et al., 2010); it exerts therapeutic and protective effect in diabetes
by decreasing
morphological changes and preserving pancreatic beta-cell integrity (Kanter et
al.,
2009) and by beneficially changing the hepatic enzyme activities (Pan i and
Sankaranarayanan, 2009); it is effective against hypertension (Khattab and
Nagi, 2007;
Dehkordi and Kamkhah, 2008); it has a potent antihistaminic effect on airways
of
asthmatic patients (Boskabady et al., 2010); its components are promising
agents to
complement schistosomiasis specific treatment (El Shenawy et al., 2008); its
oils
protects kidney tissue against oxygen free radicals, preventing renal
dysfunction and
morphological abnormalities (Bayrak et al., 2008; Uz et al., 2008; Ragheb et
al., 2009).
Other names of black seed are for black cumin, black caraway seeds, Nigella
sativa
etc.
Black seed's inherent ingredients are capable to grow and regrow hair in body.
They
are also capable to heal body and it's internal and external organs from many
diseases.
In addition, black seed is effective in healing and curing many types of
cancers
including but not limited to Blood Cancer, Breast Cancer, Colon Cancer,
Pancreatic
Cancer, Hepatic Cancer, Lung Cancer, Fibrosarcoma, Skin cancer, Renal Cancer,
Prostate Cancer etc. In addition, it can heal and cure body from many viruses
like AIDS,
Bird Flue etc. It helps fighting viruses by bringing about higher serum levels
of
interferon-gamma. In addition, it raises the number of CD4 cells and raise
their
response, it also helps T cells and suppress macrophages. Immunity against
viral
infection is also raised by it. Obesity can also be controlled with this black
seed
ingredient. Alzymers disease can also be treated with black seed ingredients.
Black
seed ingredients have anti-microbial effects on various pathogens. For
example,
bacteria, viruses, schistosome, fungus etc. The black seed ingredients can be
applied
alone or with other drugs to treat body and cure it.
Cancer in body is caused by genetic alterations and abnormal cell growth.
Black seed
ingredients can kill cancer cells by acting upon cancer cells through various
molecular
pathways. Thymoquinone (TQ) present in black seeds influence to kill apoptotic
cells in
tissue caring cancer by keeping in order apoptotic genes. In addition, Anti-
proliferative
effect of TQ from black seeds also influence positively on myeloblastic
leukemia HL-60
cells. TQ from black seed influences apoptosis and disturbs mitochondrial
membrane
strength. It also energizing caspases 8, 9 and 3 of HL-60 myeloblastic
leukemia cells.
CA 3030306 2019-07-15
Similarly, TQ also have positive influence on colon cancer cell line HCT 116.
TQ also
down-regulates the expression NF-kappa B-regulated anti-apoptotic (IAP-1, IAP-
2, XIAP
BcI-2, BcI-xL, and Survivin) gene products (Sethi et al., 2008). TO induce
apoptosis by
the activation of c-jun NH(2)-terminal kinase and p38 mitogen-activated
protein kinase
pathways in pancreatic cancer cells.(Torres et al,. 2010). TQ controls and
influence
positively on AKT pathway and body's umbilical vein endothelial cells by
supressing
activeness of AKT excess signals and regulating kinase. LPS
(lipopolysaccharides a
bacterial component) induced phosphorylation of pro-survival kinases AKT and
ERK1/2
was abrogated by TQ in dendric cells. (Xuan et al 2010).
Anti-oxidant enzymes are directly related to cancer sells. TQ increases anti-
oxidant
enzymes like super-oxides (SOD), catalase (CAT), glutathione peroxidase (GPX)
and so
on. Enzymes are effective against cancer cells of various kinds. TQ also
decrease
effects of toxic drugs used for treating cancer by up-regulating anti-oxidants
in body.
Information also taken from article Anticancer Activities of Nigella Sativa
written by Md
Asaduzzaman Khan, Han-chun Chen and Dian-zheng Zhang. Published on line July
3,
2011.
Summary:
The inherent ingredients of black seed can easily be transferred to any
liquid, solution
or compound. Some liquids, solutions or compounds can absorb the ingredients
on
room temperature and bec9me extract of black seed ingredient while other have
to be
heated. Like vinegar having acid in it will absorb ingredient without any
heating.
Similarly, other liquid, solutions or compounds may also absorb ingredients
without
heating.
We can transfer black seed ingredients in liquid, solution or compound for
example by
putting black seeds in water. If water have higher temperature than room
temperature.
The transfer of black seed ingredients may start taking place from seeds to
water. The
ration of black seeds and water can be 1:2, although it can vary. The less the
water the
higher the concentration of black seed ingredient transfer into the water. The
extract
may be more potent if ratio is lower. Longer time of heating them together may
also
affect the amount of ingredients transfer and its potency. Minimum time I
would say
could be 10 to 15 minutes of heating them together to transfer ingredients, or
could be
less than that also.. The water becomes more darker in color as more transfer
of the
ingredients take place. It is optimal to heat the water and the seeds with
steam to keep
all ingredients of black seeds effective and alive and not to kill the
ingredients with over
heating. The black seeds can be separated from the water or any liquid,
solution or
compound after the transfer of ingredients takes place and getting its
extract. The
water in this invention or any liquid, solution or compound left over after
separating
black seeds giving the extract of ingredients that can be used to give effects
of black
seed ingredients and it can be used to grow and re-grow hair and/or fight
diseases,
cancers or viruses mentioned above in body.
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This water or liquid, Solution or compound can be accompanied with other
beneficial
products to be more effective in achieving its intended purpose to deal with
the problem
of body. For example, henna leaves extract can be added by boiling them in
water or
liquid, solution or compound before getting extract of black seeds
ingredients. And
also, for example, making lotions, soaps, shampoo or any form of medicine or
any kind
of product can be developed with the water or liquid, solution or compound to
deal with
any issue of body. In addition, if we take problem of hair growth and regrowth
of body,
there are many oils that are very beneficial for hair growth or regrowth.
Black seed
ingredients in the abstract are beneficial in reducing DHT in follicles of
hair and body.
In addition, many oils have abilities to bring about good blood circulation in
the area
where body need to improve blood circulation to grow and regrow hair or some
oils
help dealing with excess DHT also and so on., for example, oils or essential
oils like
rosemary, lavender etc. can be added to the water or any liquid, solution or
compound
caring black seed abstract. Essential oils can be added in beneficial oils and
then
added in extract of black seeds ingredients. For example, safflower oil can be
used as
carrier oil, it is known for many benefits to hair and skin and its
comedogenic rating is 0.
We have to keep in mind that essential oils are very strong and are safe to be
used if
they are under 2 percent of total and final product of our water or any
liquid, solution or
compound caring black seed abstract by weight. We know oil and water or other
solutions or compounds may not mix well. We will have to add emulsifying agent
to mix
them together. There are many recipes to make lotions, soaps and various
products
and all percentages of items that can be added to make products are every
where on
internet net and in the market. They are easily accessible today. Similarly,
various
products can be developed to fight other diseases, cancers, or viruses by
adding
beneficial products or drugs to the water or liquid, solution or compound
caring black
seed abstract to be more effective in desired treatment of body. To make water
or any
liquid, solution or compound thicker we can use various products like shea
butter etc.
For prolonging shelf life various preservatives may be added. We can add
various
products to make water or liquid, solution or compound caring black seed
ingredients
to make it attractive to general public and to be used conveniently as needed.
Dead skin starts covering the area where hair start to falling on body. This
is due to low
blood circulation on that area of the body. With time the pores are blocked
with dead
cells. The skin is covered with dead cells and the area becomes bald. In
addition,
bacteria and other fungus may also start growing along with dead skin on
surface or in
hair follicles. For example, Vinegar have acid in it that dissolves the dead
cells and kills
the bacteria and fungus and exfoliate to clear skin, pores and follicles and
also clear the
path for hair to grow and regrow hair once again, when used in, along with or
used
separately from the water or liquid, solution or compound containing caring
black seed
ingredients. If vinegar is not desired to be used due to any reason, other
solutions or
products for removal of dead skin, killing bacteria and fungus and/or
exfoliating the skin
or surface of body can be used that are or may be friendly to the skin.
Other products made to exfoliate and remove dead skin can also be used, they
can be
added to our water or liquid, solution or compound caring black seed
ingredients or
may be used separately and they can be alternative of vinegar also. When acids
are to
be used to remove dead cells and exfoliate skin, precaution must be taken to
protect
14
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skin from sun light to avoid burning of the skin and other harmful effects.
Protection
from sun may be done by using sun screen or using other means of protection
skin from
rays of sun. Other ways could be used to remove dead skin. For example, derma
roller
and other products could also be used to disrupt and remove outer layer of
dead cells
and skin on surface of body and clear the path for growth and regrowth of hair
before
using water or liquid, solution or compound carrying black seed ingredients.
Other
remedies that solve the problem of removing dead skin, killing bacteria and
fungus and
exfoliating skin can also be helpful. Application of the water or liquid,
solution or the
compound caring black seed ingredients on the surface of the body will start
growing
and re-growing hair where hair was lost and bald surface appeared. The path
for
growth and regrowth of hair through the pores and follicles should be cleared
to get
better results before the water or liquid, solution or compound caring black
seed
ingredients is used on the surface of the body.
Cross reference:
For hair growth and regrowth:
1.
Patent 2782980
wo 2011/081861 PCT/US2010/060003
=
Hair Growth and/or Regrowth Compositions
Technical Field
The present disclosure relates to compositions containing certain pyrimidine
compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt)
compounds such as minoxidil sulfate and especially compositions containing
pyrimidine
compounds in combination with admixtures comprising at least one antioxidant,
at least
one organic acid and a select fatty acid mixture. The present disclosure also
relates to
use of the compositions to grow hair and/or prevent hair loss in mammals and
particularly in
humans.
Background
Various pyrimidine compounds have been suggested as being useful for growing
and/or re-growing hair in mammals including humans. For example, see U.S.
Patent 4,139,619 to Chidsey, Ill, disclosure of which is incorporated herein
by reference. In
particular, minoxidil (6-amino- 1, 2-dihydro-1-hydroxy-2-imino-4-
piperidinopyrimidine
is currently used commercially as a hair growth agent for use in the treatment
of male pattern baldness.
More recently, the use of certain pyrimidine sulfates, such as minoxidil
sulfate,
have been suggested as being useful for growing hair in mammals. In
particular, see U.S.
Patent 4,287,338. It is disclosed that the sulfates are faster and more potent
than
minoxidil in promoting hair growth. In certain situations, and/or market
segments, faster and/or thicker hair
growth or regrowth is a continuing desire and goal; hence, work continues in
developing improved
hair growth preparations.
CA 3030306 2019-07-15
2.
Patent 2232655
C:H ULL3Lb55 LUU3-11-L5
WO 97/10833 PCT/U595111905
HERBAI¨BASED ORAL COMPOSTTION AND PROCESS FOR
PRODUCING THE SAME
Field of the Invention
The present invention relates to herbal-based products, in particular to
herbal-s based gums and toothpastes for promoting darkening of hair color.
Background of the Invention Chinese herbalists have over the centuries
identified individual herbs that are
believed to have certain beneficial effects on the human body. Included among
these
herbs are Radix Polygoni Multiflora, referred to by Chinese herbalists as He
Shou Wu.
This herb is traditionally believed to be useful in the treatment of kidney
and liver
deficiencies, premature graying of the hair, relief of constipation, and skin
lesions.
Another traditional herb is Rhizoma Drynariae, otherwise known as Gu Sui Bu,
Which is traditionally believed to aid the liver and kidney, to assist in the
healing of bone fractures,
dislocations and tissue trauma, and to reduce premature balding and to promote
hair growth. The physical
characteristics of these herbs and their methods of preparation are described
in the Encyclopedia of Chinese
Medicine and Herbs, which disclosure is hereby expressly incorporated by
reference. A traditional
Generalization of the operation of these herbs the symptomology for which they
are useful, and the
activity are described in Ni, Maoshing, Chinese Herbology Made Easy, pages 138-
140, 148, 149, 1 SO, and 151,
A still further traditional Chinese herb is Herba Ecliptae, which has
traditionally been believed to aid in
restoring grayed hair to its originalcolor, and to lessen the loss of hair.
3.
= =
Patent 2652301
CA 02652301 2008-11-14
WO 2006/122396 PCT/CA2006/000765
1422-103PCT
SYSTEM AND METHOD FOR PROMOTING HAIR GROWTH AND
IMPROVING HAIR AND SCALP HEALTH =
FIELD OF THE INVENTION
The present invention relates to the field of hair and scalp treatment, and in
particular
to plant extracts for promoting hair growth.
BACKGROUND OF THE 11VVENTION
Alopecia, or hair loss, is an ongoing problem afflicting mankind and animals.
Men,
woman and children can all suffer from alopecia, which can be the result of
one, or a
combination of, a number of factors including genetic factors, hormonal
factors,
surgery, trauma and stress. The universality of the occurrence of alopecia has
led to
continuing efforts throughout history to discover compositions for stimulating
hair
growth and preventing hair loss. Hair is basically composed of a tough and
insoluble protein, keratin. Each
hair comprises a cylindrical shaft and a root, and is contained in a follicle,
which is a task-
like depression in the skin. The average human head, for example, has about
100,000
hair follicles spread across the scalp. The bottom of the follicle contains a
13nger-likeprojection termed the
papilla, which consists of connective tissue from which hair grows, and
through which blood vessels supply
CA 3030306 2019-07-15
the cells with nourishment. The shafts the part that extends outwards from the
skin surface, whilst the root
has been described as the buried part of the hair. The base of the root
expands into the hair bulb, which rests
upon the papilla. Cells from which the hair is produced grow in the bulb of
the follicle; they are extruded in
the form of fibres as the cells proliferate in the follicle. "Hair growth"
refers to the formation and elongation of
the hair fibre by the dividing cells. Hair growth is not constant, however,
because follicles are cycling
through stages of growth, rest and regression, In most mammals, the cycle of
hair
growth is seasonal and is related to daylight length and hormonal activity,
resulting in
regular periods of shedding, or moulting. By contrast, human hair follicles
generally cycle independently of
one another, with each follicle apparently having its own.
4.
Patent 3006576
CA 03006576 2018-05-28
WO 2017/116937
PCT/US2016/068185
Hair Growth Composition and Method
FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding
hair lossor facilitating hair growth comprising a hair growth active, a C8-
C2.4 alcohol ester of a carboxylic
acid and a viscosity modifying agent comprising: a nonionic hydroxypropyl
methyl cellulose and a high
molecular weight carboxymethyl cellulose at a ratio of the non ionic
hydroxypropmethyl cellulose to the high
molecular weight carboxymethyl cellulose of greater than about 1:1.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting
mankind
and animals. Men, woman and children can all suffer from alopecia, which can
be result of
one, or a combination of, factors including genetic factors, hormonal factors,
surgery, trauma,
chemotherapy, aging, certain drug side effects and stress. The universality of
the occurrence
of alopecia has led to continuing efforts throughout history to discover
compositions for
stimulating hair growth and preventing hair loss.A number of "natural"
remedies for alopecia based solely on
herbs and plant extracts
have been proposed. However, such compounds have proven clinically to have
very little If any effect.
Accordingly, an aspect of the present invention is to provide a method for
reducing
hair loss and facilitate hair growth and/or providing a thicker, denser or
richer hair coat
Another aspect of the present disclosure is concerned with methods of using
compositions comprising at least one hair growth stimulator, and at least one
C8-C24 alcohol
ester of a carboxylic acid. Another aspect of the present invention is
improving the temperature stability of
solution or gel compositions containing from about 0.1% to about 20% by weight
of a hair growth or hair
regrowth compound (such as minoxidil or pharmaceutically acceptable addition
salts thereof); from about
0.5% to about 10% by weight of an oil phase or oily.
5.
Patent 3006578
CA 03006578 2018-05-28
WO 2017/116938 PCT/US2016/068188
Hair Growth Composition and Method
FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding
hair loss
or facilitating hair growth comprising a hair growth active, a mixture of C12-
C 15 alkyl lactates
and a viscosity modifying agent comprising at least one cellulose and/or a
cellulose derivative. Clear
compositions are also disclosed.
CA 3030306 2019-07-15
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting
mankind
and animals. Men, woman and children can all suffer from alopecia, which can
be result of
one, or a combination of, factors including genetic factors, hormonal factors,
surgery, trauma,
chemotherapy, aging, certain drug side effects and stress. The universality of
the occurrence
of alopecia has led to continuing efforts throughout history to discover
compositions for
stimulating hair growth and preventing hair loss. A number of "natural"
remedies for alopecia based solely on
herbs and plant extracts have been proposed. However, such compounds have
proven clinically to have very
little if any effect Accordingly, an aspect of the present invention is to
provide a method for reducing
hair loss and facilitate hair growth and/or providing a thicker, denser or
richer hair coat. Another aspect of
the present disclosure is concerned with methods of using compositions
comprising at least one hair growth
stimulator, and at least one C8-C24 alcohol ester of a carboxylic acid.
Another aspect of the present invention
is improving the temperature stability of solution or gel compositions
containing from about 0.1% to about
20% by weight of a hair growth or hair regrowth compound (such as minoxidil or
pharmaceutically
acceptable addition salts thereof); from about 0.5% to about 10% by weight of
an oil phase or oily.
compound; from about 0% to about 60 % of a dihydric alcohol (such as propylene
glycol) and from about 0 to
about 65% by weight of a C2-C4 alcohol (such as ethanol).
6.
Patent 2152953
W094/15574 21 5 2 9 5 3 PCT/GB94/00021
COMPOSITIONS FOR TREATMENT OF THE HAIR
The present invention relates to topical compositions for the
treatment of the hair which comprise a pharmaceutically
acceptable oxalate of a group la or Ila metal or ammonium
oxalate, disposed in a pharmaceutical acceptable carrier or
diluent therefor. The pharmaceutically acceptable oxalate is
preferably an oxalate selected from calcium, barium or
magnesium, lithium, sodium or potassium and may include an
organic plant derived oxalate.
= Extracts of red and white squill have long been repotted to
have medicinal properties; white squill having the property
of being a cardiac stimulant, a diuretic or emetic. These
extracts have been utilised for this purpose for very many
years.
We have previously described how both red and white squill
extracts are useful for restoring hair loss due to conditions
such as alopecia whether or not problems of seborrhoea exist
The applicant has now found that a significant component of
this composition, in so far as hair treatment is concerned
are calcium oxalate crystals derived from the squill extract,
optionally with at least some of the mucilage associated
therewith.
Further tests revealed, however that the active principle of
such pharmaceutical compositions was a group la or ha metal
oxalate, op¨ionally with an organic oxalate and/or mucilage
CA 3030306 2019-07-15
derived from a plant extract.
In Canadian patent 888689 there is disclosed the use of a
composition for the treatment for the scalp against hair loss
which essentially requires the use of an emulsion comprising
bergamot oil, water and a ferrous salt including a ferrous
oxalate (i.e. a group VIII metal salt).
7.
Patent 1270442
HAIR TONIC COMPOSITION
BACXGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a novel hair tonic composition suitable for
use in preventing the generation
of dandruff (or scurf) in hair and itching in the scalp and in accelerating
the growth of hair. More specifically,
it relates to a novel hair tonic composition containing, as an effective
ingredient, an extract from dong chong
xia cao.
2. Description of the Related Art The possession of a healthy and profuse head
of hair throughout life is the =
=
ambition of most human beings. Various kinds of hair dressings, including hair
tonic compositions, have been
used for alleviating or curing epilation or depilation (i.e., the involuntary
loss of hair and subsequent balding). However, present, there are no truly
effective agents for allevi-
ating epilation, accelerating the growth of hair, and further alleviating or
curing the generation of dandruff
in the hair and itching in the scale. The dong chong xia cao, which is a raw
material for the hair tonic
composition of the present invention,
has been long known as a raw material for Chinese medicines. Dong chong xia
cao was first described by Wu
Iluo during the Ching dynasty in his book, Ben Cao CongXin*(Herbs from Anew).
After that it was described,
for example, in Chinese publications Zhonq Yao bacidian
(Encyclo¨edia of Chinese Medicine*,* and Zhong Cao Yaoxue (Chinese Herbal
Medicine) and Japanese
publications, Shin Tei Wakan Yaku (¨apanese and Chinese Medicine, New Ed.) by
Xinpo Akamastu, and a
large number of other publications relating to Chinese medicines. These
publications disclose various kinds of
pharmacological effects provided by dong chong xia cao, and
variousprescriptions for the use of dong chong
xia cao in p. 767-768, 1977 p. 12 13, 1976 p. 7p5-706, 1980
8.
Patent 2953957
CA 02953957 2016-12-29
WO 2016/003970 PCT/US2015/038434
MINOXIDIL-CONTAINING HAIR GROWTH COMPOSITION
CROSS-REFERENCE TO RELATED APPLICATIONS
The present application claims the benefit of United States provisional patent
application 62/019,163, filed
June 30, 2014, and United States provisional patent application 62/019,151,
filed June 30, 2014, and United
States provisional patent application 62/019,141, filed June 30, 2014, and
United States provisional patent
CA 3030306 2019-07-15
application 62/019,176, filed June 30, 2014, and United States provisional
patent application 62/019,169,
filed June 30, 2014,the entirety of which applications are hereby incorporated
by reference herein
as if fully set forth herein to the extent that they are not inconsistent with
the present application.
FIELD OF THE INVENTION
The present invention relates to compositions for and methods of retarding
hair los or facilitating hair growth
comprising a hair growth active and a C8-C24 alcohol ester of acarboxylic
acid.
BACKGROUND OF THE INVENTION
Alopecia, or hair loss, in its various forms is an ongoing problem afflicting
mankind and animals. Men, women
and children can all suffer from alopecia, which can be result of one, or a
combination of, factors including
genetic factors, hormonal factors, surgery, trauma, chemotherapy, aging,
certain drug side effects and stress.
The universality of the occurrence of alopecia has led to continuing efforts
throughout history to discover
compositions for stimulating hair growth and preventing hair loss. A number of
"natural" remedies for
alopecia based solely on herbs and plant extracts have been proposed. However,
such compounds have
proven clinically to have very little if any effect. Accordingly, an aspect of
the present invention is to provide
method for reducing hair loss and facilitate hair growth and/or providing a
thicker, denser or richer hair
coat.
9.
Patent 3000117
CA 03000117 2018-03-23
WO 2016/044951 PCT/CA2015/050966
COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH,
PROMOTING SKIN REGENERATION, AND WOUND HEALING
Background
The non-limiting embodiments disclosed herein generally relate to compositions
and methods
useful for enhancing hair growth, promoting skin regeneration, and wound
healing. The non-limiting
embodiments disclosed herein also generally related to methods of screening
for a compound capable of
increasing cell proliferation. Ther are inadequate methods for regenerating
skin or inducing hair growth in
a subject (e.g., for treatment of a disease or condition where regenerating
skin or inducing hair
growth is beneficial). In addition, impaired wound healing represents a
significant cause of morbidity
and mortality. The wound-healing process is a complex biological process where
both differentiated and
stem cells as well as cytokines/chemokines, growth factors, and skin matrix
components are essential
for effective wound healing. Expensive growth factors are often required for
cell proliferation,
and even then, expansion is often not optimal. Thus, molecules which replace
or enhance the actions of
growth factors and allow increased expansion of cells in culture, particularly
stem cells such as skin-
derived precursors (SKPs) are desirable.
Thus, there is a need for molecules that promote the proliferation and self-
renewal of cells, such
as SKPs. These molecules may be highly advantageous for cosmetic and medical
purposes (e.g., hair growth, skin regeneration, and wound healing).
Summary In a first aspect described herein, there is provided a method of
promoting
skin repair or wound healing, the method including administering to a subject
in need thereof a
composition including an effective amount of trimebutine or a pharmaceutically
acceptable salt or
active metabolite thereof. In certain non-limiting embodiments, the subject
has a burn or an ulcer, has
or previously had an infection resulting in skin loss, has undergone a
surgical procedure requiring
skin repair, or has an injury resulting in skin loss. In particular
embodiments, the composition is
administered until the wound substantially heals.
In a second aspect described herein, there is provided a method of promoting
hair growth or
treating a condition associated with hair loss, the method including
administering to a subject in need
thereof a composition including an effective amount of trimebutine or a
pharmaceutically acceptable salt
or active metabolite thereof. In particular non-limiting embodiments, the
condition associated with hair
loss is selected from the group consisting of: androgenic alopecia, alopecia
areata, anagen effluvium,
self-induced hair loss, telogen effluvium, scarring alopecia, hair loss as a
result of chemotherapy or
CA 3030306 2019-07-15
radiation treatment, supplementing hair transplant, priming skull,
administration after hair
transplant, and hair loss as a result of exposure to toxic chemicals. In
certain non-limiting embodiments, the
compositions is administered until a symptom of hair loss improves, wherein
the symptom of hair loss is
selected from the group.
10.
Patent 2998972
CA 02998972 2018-03-16
WO 2017/050891 PCT/EP2016/072531
TREATMENT OF ALOPECIA AREATA
FIELD OF THE INVENTION
The present invention relates to a new pharmaceutical use of 3-[(3S,4R)-3-
methyl-6-(7H-pyrrolo[2,3-clipyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-
oxopropanenitrile.
More specifically, the present invention relates to a therapeutic or
preventive agent for alopecia areata
whichcontains 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-
diazaspiro[3.4]octan-1-y1]-3-
oxopropanenitrile.
BACKGROUND OF THE INVENTION =
Alopecia areata (AA) is an autoimmune disease that results in hair loss that
ranges in
presentation from circular patches on the scalp that can often undergo
spontaneous
resolution to complete hair loss that may persist for life. There are
currently no FDA-
approved treatments for AA, and treatment regimens for patients with severe
disease
are empiric and frequently unsatisfactory.
CITATION LISTS
Patent literature:
Patent literature 1: JP 2011-46700 A (Japan Tobacco Inc.)
Patent literature 2: W02011/013785 (Japan Tobacco Inc.)
Non-patent literature:
Non-patent literature 1: MCELWEE, KJ et al. Experimental induction of alopecia
areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J
Invest Dermatol. Nov 1998, Vol. 111, No. 5, pages 797-803.
SUMMARY OF THE INVENTION
A. The problem to
be solved by the invention is to provide a new pharmaceutical use of 3-
[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-
1-y1]-3-oxopropanenitrile.
The present inventors found for the first time that 3-[(35,4R)-3-methyl-6-(7H-
pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-1-y1]-3-
oxopropanenitrile is effective for the treatment or prevention of alopecia
areata and that 3-
[(35,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-y1)-1,6-diazaspiro[3.4]octan-
1-y1]-3-
oxopropanenitrile is effective as a topical agent for treating alopecia areata
or a topical agent for preventing alopecia areata, and achieved the present
invention.
11.
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CA 02473097 2004-07-09
WO 03/057380 PCT/US03/00995
COMPOSITIONS INCLUDING AMMONIA OXIDIZING BACTERIA AND
METHODS OF USING SAME
Field of Invention
The present invention relates to a composition including ammonia oxidizing
bacteria to increase production of nitric oxide and nitric oxide precursors on
the surface of a subject and methods of using same to reduce blood pressure,
treat
Alzheimer's Disease, treat obesity, and treat diabetes Type 2 in a subject,
specifically
By 10 administering nitric oxide to the subject. Background Beneficial
bacteria have been utilized to suppress
the growth of pathogenic bacteria. Bacteria and other microorganisms are
ubiquitous in the environment.
The 15 discovery of pathogenic bacteria and the germ theory of disease has had
a tremendous effect on health
and disease states. Bacteria are a normal part of the intestinal contents of
all living things. These bacteria are not pathogenic under normal conditions,
and in fact
improve health by rendering the normal intestinal contents less hospitable for
disease
causing organisms. This is accomplished in a number of ways: nutrients are
consumed,
2o leaving less for pathogens; conditions are produced, such as pH, oxygen
tension, which
are not hospitable for pathogens; compounds are produced that are toxic to
pathogens;
pathogens are consumed as food by these microorganisms; less physical space
remains
available for pathogens; and specific binding sites are occupied leaving fewer
for
pathogens. The presence of these desirable bacteria is seen as useful in
preventing 25 disease states.
Fermentation of food products has been done to substitute a desired non-
pathogenic strain for potential
spoilage or pathogenic organisms. Brewed beverages,
wine, pickled food, fermented milk products including cheese, yogurt, butter
milk,sausage are all examples
where desired microorganisms are deliberately inoculated into3o food products
under conditions that favor
their growth and inhibit the growth of spoilage and pathogenic strains. U.S.
Patents disclosing the use of
specific bacteria to inhibit the growth of harmful bacteria include: U.S.
Patent No. 3,984,575 issued to Farr
October 5,
12.
Patent 2608651
CA 02608651 2007-11-15
WO 2006/128032 PCT/US2006/020542
COIVTPOSITTO'NS AND METHODS FOR THE PREVENTION AND
TREATMENT OF CONDITIONS ASSOCIATED WITH INFLAMMATION =
=
[0001] This application is entitled to and claims priority benefit under 35
U.S.C.
119(e) to U.S. Provisional application Serial No. 60/684,487 filed May 24,
2005, which is
incorporated herein by reference in its entirety,
1. FIELD OF THE INVENTION
[0002] The present invention provides methods for preventing, treating,
managing
and/or ameliorating a condition associated with inflammation (e.g., an
inflammatory
disorder) or a symptom thereof, the methods comprising administering to a
subject in need hereof an
effective amount of a theaflavin composition and an effective amount of one or
more therapies other than
such a theaflavin composition.
2. BACKGROUND OF THE INVENTION
2.1 Inflammatory Disorders [0003] Inflammation plays a fundamental role in
host defenses and the
progression of immune-mediated diseases. The inflammatory response is
initiated in response
to injury (e.g., trauma, ischemia, and foreign particles) and infection (e.g.,
bacterial
or viral infection)by a complex cascade of events, including chemical
mediators (e.g., cytokines and
CA 3030306 2019-07-15
prostaglandins) and inflammatory cells (e.g., leukocytes). The inflammatory
response is characterized by
increased blood flow, increased capillary permeability, and the influx of
phagocytic cells. These events can
result in swelling, redness, warmth (altered heat patterns), and pus formation
at the site of injury or infection.
[0004] A delicate well-balanced interplay between the humoral and cellular
Immune elements in the inflammatory response enables the elimination of
harmful agents and the
initiation of the repair of damaged tissue. When this delicately balanced
interplay is
disrupted, the inflammatory response may result in considerable damage to
normal tissue
and may be more harmful than the original insult that initiated the reaction.
In these cases
of uncontrolled inflammatory responses, clinical intervention is needed to
prevent tissue
damage and organ dysfunction. [0005] Diseases such as rheumatoid arthritis,
osteoarthritis, Crohn's disease,
asthma,allergies and inflammatory bowel disease, are characterized by chronic
inflammation. Current treatments for inflammatory disorders involve
symptomatic medications
and immunosuppressive agents to control symptoms. For example, nonsteroidal
13.
Patent 2704059
CA 02704059 2010-04-28
WO 2009/058989 PCT/US2008/081769
TITLE OF THE INVENTION
ANTIGEN - ANTIBODY COMPLEXES AS HIV-1 VACCINES
INCORPORATION BY REFERENCE
This application is a continuation in part of U.S. non-provisional application
serial no.
11/929,015 filed on 30 October 2007 and PCT International Application No.
PCT/U52007/083006 filed on 30 October 2007, which claims priority to U.S.
Provisional application serial no. 60/855,625, filed on 30 October 2006. This
application
also claims priority to U.S. provisional application serial no. 61/035,653,
filed on 11
March 2008. The foregoing applications, and all documents cited therein or
during their
prosecution ("appin cited documents) and all documents cited or referenced in
the appin
cited documents, and all documents cited or referenced herein ("herein cited
documents"), and all documents cited or referenced in herein cited documents,
together with
any manufacturer's instructions, descriptions, product specifications, and
product
sheets for any products mentioned herein or in any document incorporated by
reference herein,
are hereby incorporated herein by reference, and may be employed in the
practice of the
invention. FIELD OF THE INVENTION
The present invention relates to antigen-antibody complexes for use as
prophylactic
and therapeutic vaccines for infectious diseases of AIDS. BACKGROUND OF THE
INVENTION
AIDS, or Acquired Immunodeficiency Syndrome, is caused by human
immunodeficiency virus (HIV) and is
characterized by several clinical features including wasting syndromes,
central nervous system
degeneration and profound immunosuppression that results in opportunistic
infections and malignancies.
HIV is a member of the lentivirus family of animal retroviruses, which include
the visna virus of sheep and
the bovine, feline, and simian immunodeficiency viruses (SW). Two closely
related types of HIV,
Designated HIV-1 and HIV-2, have been identified thus far, of which HIV-1 is
by far the most common
cause of AIDS. However, HIV-2, which differs in genomic structure and
antigenicity, causes
a similar clinical syndrome.An infectious HIV particle consists of two
identical strands of RNA, each
CA 3030306 2019-07-15
=
approximately 9.2 kb long, packaged within a core of viral proteins. This core
structure is
surrounded by a phospholipid bilayer envelope derived from the host cell
membrane that also
includes virally-encoded membrane proteins (Abbas et al., Cellular and
Molecular
Immunology, 4th edition, W.B. Saunders Company, 2000, p.454). The HIV genome,
14.
Patent 2632045
CA 02682045 2009-09-23
WO 2008/118936 PCT/U52008/058206
RECOMBINANT MODIFIED ANKARA VIRAL HIV-1 VACCINES
INCORPORATION BY REFERENCE
This application claims priority to U.S. provisional patent application Serial
No.
60/908,082 filed March 26, 2007.
The foregoing applications, and all documents cited therein or during their
prosecution ("appin cited documents") and all documents cited or referenced in
the appin
cited documents, and all documents cited or referenced herein ("herein cited
documents"),and all documents cited or referenced in herein cited documents,
together
with any manufacturer's instructions, descriptions, product specifications,
and product
sheets for any products mentioned herein or in any document incorporated by
reference
herein, are hereby
incorporated herein by reference, and may be employed in the practice of the
invention.
FIELD OF THE INVENTION
The field of the present invention relates to novel recombinant modified
Ankara viral
vectors (MVA) encoding HIV-1 antigens for use as HIV-1 vaccines.BACKGROUND OF
THE
INVENTION AIDS, or Acquired Immunodeficiency Syndrome, is caused by human
immunodeficiency virus (HIV) and is characterized by several clinical features
including
wasting syndromes, central nervous system degeneration and profound
immunosuppression
that results in opportunistic infections and malignancies. HIV is a member of
the lentivirus
family of animal retroviruses, which include the virus of sheep and the
bovine, feline, and simian immunodeficiency viruses (SR). Two closely related
types of
HIV, designatedHIV-1 and HIV-2, have been identified thus far, of which HIV-1
is by far the
most common cause of AIDS. However, HIV-2, which differs in genomic structure
and =
antigenicity, causes a similar clinical syndrome. An infectious HIV particle
consists of two
identical strands of RNA, each approximately 9.2 kb long, packaged within a
core of viral
proteins. This core structure is surrounded by a phospholipid bilayer envelope
derived from
the host cell membrane that also includes virally-encoded membrane proteins
(Abbas et al.,
Cellular and Molecular Immunology, 4th edition, W.B. Saunders Company, 2000,
p. 454).
The HIV genome has the characteristic 5'-LTR-Gag-Pol-Env-LTR-3' organization
of the
retrovirus family. Long terminal repeats (LTRs) at each end of the viral
genome serve as
binding sites for transcriptional regulatory proteins from the host and
regulate
viral integration into the host genome, viral gene expression, and viral
replication.
15.
Patent 2901737
CA 02901737 2015-08-18
WO 2014/130162 PCT/US2013/078550
=,
CA 3030306 2019-07-15
METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND
MANIPULATING MICROBES IN TUMORS
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of United States Provisional Patent
Application no. 61/766,501, filed February 19, 2013, the subject matter of
which is
hereby incorporated by reference as if fully set forth herein
BACKGROUND
[0002] One in eight women will be diagnosed with breast cancer in their
lifetime.
It is the second leading cause of death in women, with >40,000 deaths annually
(Jemal, 2010). Over the past twenty years over 5.5 billion dollars have been
spent
on breast cancer research. While progress has been made in treatment and
screening there
are still 40,000 deaths from breast cancer a year in the United States. While
genes and radiation are among known breast cancer causes, the origins of a
majority of
breast cancer cases remain unknown (Madigan, 1995). It is important to
understand how
these sporadic breast cancers arise in order to develop preventative
strategies against
this devastating disease. The recent appreciation of the influence of
microbiota on
human health and disease begs the question of whether microbes play a role in
sporadic breast cancers of unknown etiology.[0003] Infections and chronic
inflammation
have been linked to some cancers but
studies of infectious causes of breast cancer have been limited to looking for
specific
viral signatures in invasive cancers. The breast ducts are intimately
associated with
cutaneous and oral microorganisms during lactation and sexual activity, and
could well harbor infectious agents that contribute to carcinogenesis. It
would therefore
be beneficial to determine whether bacteria play a role in the development of
breast cancer.
SUMMARY
[0004] In some embodiments, methods of determining that a subject has cancer
or is at higher risk of developing cancer based on the level of microbes
present in tumor.
16.
Patent 2395678
CA 02395678 2006-09-28
74667-200
ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
FIELD OF THE INVENTION
The present invention relates to compositions and methods for decreasing the
infectivity, morbidity, and rate of mortality, associated with a variety of
pathogens. The
present invention also relates to methods and compositions for decontaminating
areas samples, solutions, and foodstuffs, colonized or otherwise infected by
pathogens and microorganisms.
BACKGROUND OF THE INVENTION
Pathogens such as bacteria, fungi, viruses, and bacterial spores are
responsible for a
plethora of human and animal ills, as well as contamination of food and
biological and
environmental samples. The first step in microbial infections of animals is
generally
attachment or colonization of skin or mucus membranes, followed by subsequent
invasion and
dissemination of the infectious microbe. The portals of entry of pathogenic
bacteria are
predominantly the skin and mucus membranes. In particular, bacteria of the
Bacillus genus form stable
spores that resist harsh conditions and extreme temperatures. Contamination of
farmlands with B. anthracis
leads toa fatal disease in domestic, agricultural, and wild animals (See e.g.,
Dragon and Rennie, Can.
CA 3030306 2019-07-15
Vet. J. 36:295 [1995]). Human infection with this organism usually results
from contact with
infected animals or infected animal products (See e.g., Welkos et al., Infect.
Immun. 51:795
[1986]). Human clinical syndromes include a pulmonary form that has a rapid
onset.
17.
Patent 2395678
CA 02857299 2014-07-21
JC05111USNP
METHOD OF TREATING A SKIN CONDITION
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to a method of using compositions
comprising plan textracts to treat a skin condition. More specifically, the
present invention
relates to a method of using compositions comprising extracts of Malva
neglecta for improving the
condition and appearance of the skin, such as by enhancing skin barrier
protection,
improving, reducing, inhibiting or delaying the appearance of at least one
sign of aging in skin,
and / or lightening skin. DESCRIPTION OF RELATED ART
[0002] Malva neglecta is typically designated a "weed." Native to the "Old
World," it has
been naturalized throughout North America. Malva neglecta is native to almost
all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway, Sweden,
United Kingdom),
middle Europe (e.g., Austria, Belgium), Southeastern Europe (e.g., Albania,
Bulgaria,
Croatia, etc.), to Southwestern Europe (e.g., France, Portugal, Spain). It is
also found in
Western Asia, the Arabian Peninsula, Northwestern Asia (e.g., Armenia,
Georgia, Kazakhstan,
Uzbekistan, Mongolia) and also in China and the Indian subcontinent. In
Africa, it is
found mostly in North Africa, such as Algeria and Morocco. [0003] Many Malva
species are used in traditional
medicinal systems around the world,including Malva neglecta. It has also been
commonly used as a food. It
has not been commercialized as a trade herb. It is also known by various
common names - Common
mallow,buttonweed, cheeseplant, cheeseweed, dwarf mallow, and roundleaf
mallow.
[0004] According to Plants For A Future
(http://www.pfaf.org/user/default.aspx), the online
database for medicinal and edible wild plants, Malva neglecta is described for
use as anti-inflammatory, anti-phlogistic, astringent, demulcent, diuretic,
emollient,
expectorant, laxative, poultice, purgative, and salve. [0005] The uses of
Malva neglecta disclosed in Plants For
A Future, as well as other knownuses of Malva neglecta described in other
references, are mostly in ingested
forms, except for use as an emollient or salve or poultice. Some traditional
literature also describes the use of
a poultice for eczema. =
18.
CA 02646263 2009-01-13
The studies of medicines are a challenging opportunity for those who take
interest.
The study of chemistry, medicines, applications and doses seem to vary between
creatures.
NIC will progressively seek Council of Independent Nations for NIC whose
primary goalis to collect and control disease. The NIC cleansing facility and
the NIC
disease control facilitywill be used to provide a way in which to reach our
primary goal.
The NIC cleansing facility will be a unique facility designed to collect
contaminated wastes and
diseases to be contained at a NIC disease control facility by means decided by
Nations
Independent Council. NIC will be a council of Ten independent councils. Seven
of which will
pertain to NIC cleansing facility and Three of which pertain to NIC disease
control facility.
Meetings and schedules decided and controlled by NIC disease control facility.
The average living creature contains multiple imperfections in health which is
caused by
disease. It is the build up of disease that causes pain and without the means
to flush out thedisease a living creature will become.overburdened by the
build up of disease and increase in
pain which is what causes loss of health, loss of spirit and eventually end
with death. By adding
CA 3030306 2019-07-15
certain cleansing agents it is possible to flush out the different organs of
living creatures,
extracting disease from the creature into concentrated toxics. The toxics are
withdrawn from the
organs by a combination of cleansing agents timely administered to flush and
chase different
diseases out of different orifices. Build ups of almost every type of disease
is virtually chased
outside the creature. The NIC cleansing facility will control extraction and
collection.
19.
Patent 2857341
CA 02857314 2014-07-21
3C05112USNP
COMPOSITIONS CONTAINING EXTRACT OF
WITH MALVA NEGLECTA
FIELD OF INVENTION
[0001] The present invention relates to compositions comprising plant extracts
for use on
skin. More specifically, the present invention relates to compositions
comprising extracts of MaIva neglecta for improving the condition and
appearance of the
skin, such as by enhancing skin barrier protection, improving, reducing,
inhibiting or
delaying the appearance of at least one sign of aging in skin, and / or
lightening skin.
DESCRIPTION OF RELATED ART
[0002] MaIva neglecta is typically designated a "weed." Native to the "Old
World," it has been naturalized throughout North America. MaIva neglecta is
native to
almost all of Europe, from northern Europe (e.g., Denmark, Ireland, Norway,
Sweden,
United Kingdom), middle Europe (e.g., Austria, Belgium), Southeastern Europe
(e.g.,
Albania, Bulgaria, Croatia, etc.), to Southwestern Europe (e.g., France,
Portugal, Spain). It
is also found in Western Asia, the Arabian Peninsula, Northwestern Asia (e.g.,
Armenia,
Georgia, Kazakhstan, Uzbekistan, Mongolia) and also in China and the Indian
subcontinent. -
In Africa, it is found mostly in North Africa, such as Algeria and Morocco.
[0003] Many MaIva species are used in traditional medicinal systems around the
world,
including MaIva neglecta. It has also been commonly used as a food. It has not
been
commercialized as a trade herb. It is also known by various common names -
Common
mallow, button weed, chees eplant, cheese weed, dwarf mallow, and round leaf
mallow.[0004] According to Plants For A Future
(http://www.pfalorg/user/default.aspx),
the online
database for medicinal and edible wild plants, MaIva neglecta is described for
use as anti- =
inflammatory, anti-phlogistic, astringent, demulcent, diuretic, emollient,
expectorant,
laxative, poultice, purgative, and salve.[0005] The uses of MaIva neglecta
disclosed in
Plants For A Future, as well as other known uses of MaIva neglecta described
in other
references, are mostly in ingested forms, except for use as an emollient
osalveorpoultice.
Some traditional literature also describes the use of a poultice for eczema.
CA 3030306 2019-07-15
