Note: Descriptions are shown in the official language in which they were submitted.
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WOVEN, NONWOVEN, COTTON, NONWOVEN-COTTON BLENDED
POLYETHYLENE AND POLIPROPILEN AND POLYSTYRENE MASK,
WOUND DRESSING, PANTY, BRA, HANDKERCHIEF, PAD,
SCOURING PAD, DISPOSABLE SURGICAL DRESS, DISPOSABLE
SHEETS WITH ANTIMICROBIAL PROPERTIES
FIELD OF THE INVENTION
This invention relates to woven, nonwoven, cotton, nonwoven- cotton blended
and
polystyrene mask, wound dressing, panty, bra, handkerchief, pad, scouring pad,
disposable surgical dress, disposable sheets with antimicrobial properties.
The
present invention relates to woven, nonwoven, cotton, nonwoven- cotton
blended,
polyethylene and polipropilen and polystyrene fabric material having
antimicrobial
activity, and to its uses ranging from wound dressing, facial masks, surgical
drapes
and surgical clothing, to filter materials, panty, bra, handkerchief, pad,
scouring
pad, disposable sheets and similar applications where the antimicrobial
effects are
employed, as well as to a process for the preparation of the woven, nonwoven,
cotton, nonwoven- cotton blended, polyethylene and polipropilen and
polystyrene
fabric material. The present invention relates to a combination polymeric
guanidine
derivative based on a diamine containing oxyalkylene chains between two amino
groups, with the guanidine derivative representing a product of
polycondensation
between a guanidine acid addition salt and a diamine containing
polyoxyalkylene
chains between two amino groups, Hexamethylenediamine (1,6 -hexanediamine)
guanidinium derivatives, particularly to combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as
an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
(Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants
like humic acids and some natural products like phytotherapeutic plant
extracts for
the production of a liqid, powder and tablette form for antimicrobial
activity.
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The use of a polymeric guanidine derivative based on a diamine containing
oxyalkylene chains between two amino groups (Formul I), with the guanidine
derivative representing a product of polycondensation between a guanidine acid
addition salt and a diamine containing polyoxyalkylene chains between two
amino
groups and hexamethylenediamine (1,6-hexanediamine), for the production of a
drug composition with antimicrobial activity. General formulation is
consisting of
Formule I, II, III, IV, V and VI).
H2N
C = NH
H2N
C - NH x HCI
H2N
Formula I
N H
N N
Formula II
2
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CH
H2cpt, I 'y NHz.
H2N.,{1
0 x z
CH, R CH,
Formula III
,NH z-
H 0
Formula IV
C.) 0
g
0
Formula V
LJ
____________ C-C
Formula VI
3
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'-':'',',..4 r--' e:
,-Fi ,=,...e' .?
\ 4
,
H. ,iii ON ',NH, 2,4. s
',Rh
. .41'=-?" '3 il'''''," EVi.
I 2, 1 ,i,, , I-k.: / , ._iii
...%;.= ..> isi,
,iii-:
r; I: k= ,,C) -, ( . 2
I
; . . !I ¨ ;='. . i.,,, k) E-
:,..g......i.:s
mi-(i, \'''
:, .p..... ,....-- =:,..,. ,r.s,..2/` K..,..,, r.õ .4: __,
'-':: , .N.:. . , - ,.. '
'':,
2.,- .? 1.: ,.==!...õ t, ,
¨
! ,
..) Hit`i,.. a, ::? ''`,.
=:- ',. +.,
= !1.74...,;s1, 1 ,õ.c= ' r ,4,1,,' /
A,..,
I
H.., 't4e: 0: -.e.k.... ,9 Ile
C < i _
/ rõ ,__-.14i
dl. ,..-- = ',/, ,==
Z ,---'
.11
jtc-L---' L 1 -1
,-,S., , ''=-, ;:--,..:- c-4.=.., 3
NI
,. ,i''' V A , = ...,'
/:,..
I U.11:7,4:1..., I_ z .."
....
51H
4.
. v
Synthesis production of OH Hyjen DM
BACKGROUND OF THE INVENTION
5 In
recent years, the increased occurrence of hospital-acquired infections has had
serious implications for both patients and healthcare workers in addition to
the
antihydrogen conditions encountered in normal life. Hospital-acquired
infections
typically originate in a hospital or long-term care setting. Consequently,
hospitals
and other healthcare facilities extensively use materials impregnated or
otherwise
foreseen with antimicrobial agents for a variety of topical applications, such
as
wound dressings and drapes, and/or sterile drapes and articles that need to be
discarded after a short usage due to infection risks.
Surgical drapes are presently made from woven, nonwoven, cotton, nonwoven-
cotton blended, polyethylene and polipropilen and polystyrene fabrics, and are
typically used during surgical procedures to isolate the patient from the
operating
room personnel and the environment of the operating room. Contact with
contaminated liquids through surgical drapes has been considered as a primary
source of bacterial contamination for patients.
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Typically, drapes equipped with chemical antimicrobial agents are employed to
avoid this, which typically must be present at a relatively high concentration
to
achieve the desired level of efficacy. The use of antibacterial or antifungal
agents
in non-woven fabrics is for instance disclosed in U.S. Pat. No. 4,111,922.
Unfortunately, however, the required high levels of antimicrobial agents
employed
are undesired in many cases. For instance, the use of high levels of certain
types of
antimicrobial agents may be undesired due to an increased likelihood of
contacting
sensitive areas, such as wounds. And even if a patient does not suffer from
adversary effects from contact with a chemical antimicrobial agent, most
presently
employed antimicrobial compositions loose efficacy over time, since the
microbiological pathogens develop resistance, such as for instance exemplified
by
methicilin-resistant staphylococcus aureus (MRSA). This resistance spread is
exacerbated by the low number of antibiotics in the development pipeline which
could result in a major world-wide public health problem.
Various substrates coated with nanosilver particles or impregnated with sivler
salts
have been reported to develop antimicrobial properties, as for instance as
disclosed
by Ronen Gottesman et al, Langmuir, 2011, 27 (2), pp 720-726. However, the use
and application of silver salts, or colloidal silver particles usually
requires the use
of complex application technologies, e.g. sonochemical application or
impregnation with dispersions, which if applicable at all due to the
sensitivity of in
particular non-woven materials to water or solvents requires handling of
solvents
and their removal, as well as drying of the obtained products. For instance, a
commonly reported approach involves to reduce a solution of silver nitrate and
to
deposit the silver particles on a polymeric fibre, e.g. nylon, via a process
referred
to as electroless deposition. The obtained silver laden polyamide is attached
to a
subsequent fibre layer. This renders the application process complex and
cumbersome. Furthermore, the silver particles will be distributed over the
whole
material and not available at the contact area with moisture, such as in skin
contact.
Therefore, in order to be effective, such materials require a relatively high
silver
loading, which makes a widespread use prohibitively difficult. Yet further,
due to
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the complexity and nature of this process, it is difficult to control the
amount of
silver deposited on the fibre and furthermore, the amount of silver deposited
is
limited by the surface area of the fibre.
For this reasons, the antimicrobial products which have been developed to date
have
all the features of dipping process and have short-term stability and
weariness,
while the method developed in the present invention has the ability to
penetrate into
the structure of woven, nonwoven, cotton, nonwoven- cotton blended,
polyethylene and polipropilen and polystyrene materials to increase effcieny
and
long term stability.
Thus, antimicrobial effcetivines has not been successfully developed and
applied to
a substrate having the combination of characteristics described here in, as
desired
for an effective antimicrobial properties of wound dressing, facial masks,
surgical
drapes and surgical clothing, to filter materials, panty, bra, handkerchief,
pad,
scouring padõ disposable sheets and similar applications as well as to a
process for
the preparation of the woven, nonwoven, cotton, nonwoven- cotton blended,
polyethylene and polipropilen and polystyrene fabric material.
This is also advantageous for application to porous or foam materials because
antimicrobial agents are not incorporated into the material in areas that will
never
come into contact with the microbial pathogens.
Likewise, hospitals, some office, house and generally facilities sensitive to
microbiological pathogens have been increasingly facing issues with
microbiological contamination of the air, spread through building air handling
systems, specifically in Heating Ventilating and Air Conditioning (HVAC)
systems. HVAC system components usually operate in a warm, dark and humid
environment, which makes it an ideal breeding ground for microbes such as
bacteria
and/or fungi. The microbiological contamination cause odour in their mildest
form,
but generally may cause much graver issues. This is in particular relevant as
building air handling and ventilation is increasingly employed.
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The microbial contamination frequently found includes fungi such as
Aspergillus
spp., Fusariurn spp., Penicillium chrysogenurn and/or Candida albicans, but
also
Legionella, a pathogenic Gram negative bacterium, including species that cause
legionellosis or "Legionnaires' disease", most notably, Legionella
pneumophila,
has caused many issues with infections transmitted through HVAC systems.
The presence of such pathogens is usually treated in various ways, including
adding
microbial chemical agents into the humid sections of HVAC systems.
Accordingly,
the use of filters and other parts in HVAC or general air handling systems, in
particular filter elements with intrinsically antimicrobial activity would be
highly
advantageous.
As such, a need currently exists for equipping materials such as gloves,
bedding
textiles, surgical drapes, table paper, gowns, and facial masks, drape sheets,
and
others such as air and water filters with high and continuous antimicrobial
activity
at a relatively low level of an antimicrobial agent. Furthermore, this would
allow
storing such materials under non-sterile conditions.
Applicants have now surprisingly found that fabrics, both woven, nonwoven,
cotton, nonwoven- cotton blended, polyethylene and polipropilen and
polystyrene
with antimicrobial activity can be provided by a simple process which permits
to
prepare and/or convert the materials with high quality, high antimicrobial
activity,
low costs and long term stability.
Accordingly, the present invention relates to a fabric material having
antimicrobial
activity, comprising: (a) a woven, non-woven and non woven-cotton fabric
material, and (b) fabric material having a thickness of from 5 to 100 nm, 10
to 70
gsm
The term "antimicrobial activity" as used herein refers to a material that
destroys,
inhibits or prevents the propagation, growth and multiplication of unwanted
microbial organisms such as bacteria, fungia and virus.
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The term "microbial organisms" or "microbes" includes, but is not limited to,
microorganisms, bacteria, undulating bacteria, spirochetes, spores, spore-
forming
organisms, gram-negative organisms, gram-positive organisms, yeasts, fungi,
moulds, viruses, aerobic organisms, anaerobic organisms and mycobacteria.
Specific examples of such organisms include the fungi Aspergillus niger,
Aspergillus flavus, Rhizopus nigricans, Cladosporium herbarium, Epidermophyton
floccosum, Trichophyton mentagrophytes, Histoplasma capsulatum, and the like;
bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris,
Staphylococcus aureus, Staphylococcus epidermis, Streptococcus faecalis,
Klebsiella, Enterobacter aero genes, Proteus mirabilis, other gram-negative
bacteria and other gram-positive bacteria, mycobactin and the like, as well as
yeasts,
such as Saccharomyces cerevisiae, Candida albicans, and the like.
Additionally,
spores of microorganisms, viruses and the like are microbial organisms within
the
scope of the present invention.
Preferably, the antimicrobial layer lie on on the all surface of woven,
nonwoven,
cotton, nonwoven- cotton blended, polyethylene and polipropilen and
polystyrene
fabric material and that imparts the antimicrobial activity comprises a
combination
polymeric guanidine derivative based on a diamine containing oxyalkylene
chains
between two amino groups, with the guanidine derivative representing a product
of
polycondensation between a guanidine acid addition salt and a diamine
containing
polyoxyalkylene chains between two amino groups, hexamethylenediamine (1,6-
hexanediamine) guanidinium derivatives, particularly to combinations of
oligo(2-
(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene
guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine
guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148),
Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino
acids, antioxidants like humic acids and some natural products like
phytotherapeutic plant extracts for the production calculated on the other
metal(s)
by weight.
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The present invention also advantageously relates to woven, nonwoven, cotton,
nonwoven- cotton blended, polyethylene and polipropilen and polystyrene fabric
material, whereby high cation capacity of synthesiz antimcirobial material
inhibited
all of the bacteria and fungia nad virus contaminated surface.
The present invention refers to fabric materials including to woven, nonwoven,
cotton, nonwoven- cotton blended, polyethylene and polipropilen and
polystyrene
fabric material and/or film surfaces.
Woven or nonwoven fabric materials are usually defined as sheet or web
structures
bonded together by entangling of fibres or filaments, and/or by perforating
films
mechanically, thermally or chemically. They are typically flat, porous, sheet
like
structures that are made from separate fibres, and/or from molten plastic or
plastic
film. Woven or nonwoven fabrics provide specific functions such as absorbency,
liquid repellence, resilience, stretch, softness, strength, flame retardancy,
washability, cushioning, filtering, use as a bacterial barrier and sterility.
Woven fabric according to the present invention may be formed from fibres
Woven
fabrics according to the invention are typically prepare from fibres and/or
yarn
prepared from fibres, such as synthetic fibres, natural fibres, or
combinations
thereof.
The process usually involves steps such as weaving or knitting, and it does
not
necessarily require converting fibres to yarn.
Synthetic fibres include, for example, polyester, acrylic, polyamide,
polyolefin,
polyaramid, polyurethane, regenerated cellulose, and blends thereof. More
specifically, polyester, polyethylene and polipropilen, high impact
polystyrene
includes, for example, polyethylene terephthalate, polytriphenylene
terephthalate,
polybutylene terephthalate, polylactic acid, and combinations thereof.
Polyamide
includes, for example, nylon-6, nylon-6.6, and combinations thereof.
Polyolefins
include polypropylene, polyethylene, and combinations thereof.
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Polyaramid includes, for instance poly-p-phenyleneteraphthalamid (i.e., Kevlar
(iD), poly-m-phenyleneteraphthalamid (i.e., Nomex (E)), and combinations or
variations thereof.
Natural fibres include, for example, wool, cotton, flax, cellulose and blends
thereof.
The fabric may be formed from fibres or yarns of any size, including
microdenier
fibres and yarns (fibres or yarns having less than one denier per filament).
The fibres
or yarns may have deniers that range from less than about 1 denier per
filament to
about 2000 denier per filament or more preferably, from less than about 1
denier
per filament to about 500 denier per filament, or even more preferably, from
less
than about 1 denier per filament to about 300 denier per filament.
Furthermore, the fabric may be partially or wholly comprised of multi-
component
or bicomponent fibres or yarns which may be splittable along their length by
chemical or mechanical action. The fabric may be comprised of fibres such as
staple
fibre, filament fibre, spun fibre, or combinations thereof.
The fabric may be of any variety, including but not limited to, woven fabric,
knitted
fabric, nonwoven fabric, or combinations thereof. They may optionally be
coloured
by a variety of dyeing techniques, such as high temperature jet dyeing with
disperse
dyes, thermosol dyeing, pad dyeing, transfer printing, screen printing, or any
other
technique that is common in the art for comparable, equivalent, traditional
textile
products. If yarns or fibres are treated by the process of the current
invention, they
may be dyed by suitable methods prior to fabric formation, such as, for
instance, by
package dyeing or solution dyeing, or after fabric formation as described
above, or
they may be left undyed.
The film may include thermoplastic materials, thermoset materials, or
combinations
there of.
Thermoplastic or thermoset materials may include polyolefin, polyester,
polyamide, polyurethane, acrylic, silicone, melamine compounds, polyvinyl
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acetate, polyvinyl alcohol, nitrile rubber, ionomers, polyvinyl chloride,
polyvinylidene chloride, chloroisoprene, or combinations thereof. The
polyolefin
may be polyethylene, polypropylene, ethylvinyl acetate, ethylmethyl acetate,
or
combinations thereof. Polyethylene may include low density or high density
polyethylene. The film may have a thickness of between 1 and 500 [tm,
preferably
between 2 [tm and 250 [tm, or even more preferable between about 3 and 100
[tm.
Typically, the process to prepare a non-woven fabric does not involve process
steps
such as weaving or knitting, and it does not require converting fibres to
yarn, and
yarn to fabric. Nonwoven fabrics may be engineered for a single use, limited
life or
a durable fabric.
The nonwoven fabric material preferably is a nonwoven web which may include
nonwoven webs manufactured by any of the commonly known processes for
producing nonwoven webs. As used herein, the term "nonwoven web" refers to a
fabric that has a structure of individual fibres or filaments which are
randomly
and/or unidirectionally interlaid in a mat-like fashion.
For example, the fibrous nonwoven web can be made by carded, air laid, wet
laid,
spunlaced, spunbonding, electrospinning or melt-blowing techniques, such as
melt-
spun or melt-blown, or combinations thereof. Spunbonded fibres are typically
small
diameter fibres that are formed by extruding molten thermoplastic polymer as
filaments from a plurality of fine, usually circular capillaries of a
spinneret with the
diameter of the extruded fibres being rapidly reduced. Meltblown fibres are
typically formed by extruding the molten thermoplastic material through a
plurality
of fine, usually circular, die capillaries as molten threads or filaments into
a high
velocity, usually heated gas (e.g., air) stream which attenuates the filaments
of
molten thermoplastic material to reduce their diameter. Thereafter, the
meltblown
fibres are carried by the high velocity gas stream and are deposited on a
collecting
surface to from a web of randomly disbursed meltblown fibres. Any of the non-
woven webs may be made from a single type of fibre or two or more fibres that
differ in the type of thermoplastic polymer and/or thickness.
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Staple fibres may also be present in the web. The presence of staple fibres
generally
provides a loftier, less dense web than a web of only melt blown microfibers.
Preferably, no more than about 20 weight percent staple fibres are present,
more
preferably no more than about 10 weight percent. Webs containing such staple
fibre
are for instance disclosed in U.S. Pat. No. 4,118,531.
The nonwoven fabric may advantageously be fashioned or shaped in any suitable
article. Such an article may optionally further comprise one or more layers of
scrim.
For example, either or both major surfaces may each optionally further
comprise a
scrim layer. The scrim, which is typically a woven or nonwoven reinforcement
made from fibres, is included to provide strength to the nonwoven article.
Suitable
scrim materials include, but are not limited to, nylon, polyester, fibreglass,
and the
like. The average thickness of the scrim can vary. Typically, the average
thickness
of the scrimranges from about 25 to about 100 [tm, preferably about 25 to
about 50
[tm. The layer of the scrim may optionally be bonded to the nonwoven article.
A
variety of adhesive materials can be used to bond the scrim to the polymeric
material. Alternatively, the scrim may be heat-bonded to the nonwoven. The
micro
fibres of the nonwoven fabric material substrate typically have an effective
fibre
diameter of from about 0.5 to 15 [tm, preferably from about 1 to 6 [tm, as
calculated
according to the method set forth in Davies, C. N., "The Separation of
Airborne
Dust and Particles," Institution of Mechanical Engineers, London, Proceedings
TB,
1952.
The nonwoven fabric material preferably has a basis weight in the range of
about
10 to 400 g/m2, more preferably about 10 to 100 g/m2. The average thickness of
the
nonwoven fabric material is preferably about 0.1 to 10 mm, more preferably
about
0.25 to 5 mm for the non-functionalized, and uncalendared fabric material.
The minimum tensile strength of the nonwoven web is at least 3.0, preferably
at
least 4.0 Newtons. It is generally recognized that the tensile strength of
nonwovens
is lower in the machine direction than in the cross-web direction due to
better fibre
bonding and entanglement in the latter.
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Nonwoven web loft is measured by solidity, a parameter that defines the solids
fraction in a volume of web. Lower solidity values are indicative of greater
web
loft. Useful nonwoven fabric materials typically have a solidity of less than
20%,
preferably less than 15%, as defined in WO-A-2010151447. Solidity is used
herein
to refer to the nonwoven fabric material itself and not to the functionalized
nonwoven. When a nonwoven fabric material contains mixtures of two or more
kinds of fibres, the individual solidities are determined for each kind of
fibre using
the same L[nonwoven] and these individual solidities are added together to
obtain
the web's solidity, dt.
As an example, the nonwoven fabric material before calendering or grafting
preferably has an average pore size of 14 [tm, calculated from a thickness of
0.34
mm, effective fibre diameter of 4.2 um and solidity of 13%. After calendering
the
nonwoven web will have a thickness of 0.24 mm and solidity of 18% with an
average pore size of 8 [tm. The term "average pore size", also referred to as
average
pore diameter is related to the arithmetic median fibre diameter and web
solidity
and can be determined as disclosed in WO-A-2010/151447.
The nonwoven fabric material preferably has a mean pore size of 1-40 [tm,
preferably 2-20 [tm. Mean pore size may be measured according to ASTM F 316-
03 "Standard Test Methods for Pore Size Characteristics of Membrane Filters by
Bubble Point and Mean Flow Pore Test Method B" using Freon TFTm as the test
fluid. The nonwoven fabric material may be formed from any suitable
thermoplastic
polymeric material. Suitable polymeric materials include, but are not limited
to,
polyolefins, poly(isoprenes), poly(butadienes), fluorinated polymers,
chlorinated
polymers, polyamides, polyimides, polyethers, poly(ether sulfones),
poly(sulfones), poly(vinyl acetates), copolymers of vinyl acetate, such as
poly(ethylene)-co-poly(vinyl alcohol), poly(phosphazenes), poly(vinyl esters),
poly(vinyl ethers), poly(vinyl alcohols), and poly(carbonates).
Suitable polyolefins include, but are not limited to, poly(ethylene),
poly(propylene),
poly(1-butene), copolymers of ethylene and propylene, alpha olefin copolymers
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(such as copolymers of ethylene or propylene with 1-butene, 1-hexene, 1-
octene,
and 1 -decene), poly(ethylene-co- 1 -butene) and poly(ethylene -co - 1 -butene-
co- 1 -
hexene).
Suitable fluorinated polymers include, but are not limited to, poly(vinyl
fluoride),
poly(vinylidene fluoride), copolymers of vinylidene fluoride (such as
poly(vinylidene fluoride-co-hexafluoropropylene), and copolymers of
chlorotrifluoroethylene (such as poly(ethylene-co-chlorotrifluoroethylene).
Suitable polyamides include, but are not limited to, nylon 6, nylon 6,6, nylon
6, 12
poly(iminoadipoyliminohexamethylene), poly(iminoadipoyliminodecamethylene),
and polycaprolactam. Suitable polyimides include poly(pyromellitimide).
Suitable
poly(ether sulfones) include, but are not limited to, poly(diphenylether
sulfone) and
poly(diphenylsulfone-co-diphenylene oxide sulfone).
Suitable copolymers of vinyl acetate include, but are not limited to,
poly(ethylene-
co-vinyl acetate) and such copolymers in which at least some of the acetate
groups
have been hydrolyzed to afford various poly(vinyl alcohols) including,
poly(ethylene-co-vinyl alcohol).
Preferred polymers are inherently hydrophilic and are readily grafted by
ionizing
radiation, such as by exposure to e-beam or gamma radiation. Preferred
polymers
include of polyamides and ethylene vinyl alcohol polymers and copolymers.
For surgical drapes or gowns or similar apparel, preferred nonwoven fabric
sheets
are made from wood pulp; fibres of a thermoplastic polymeric material,
including
melt-blown polymer fibres, such as melt-blown polypropylene fibres, and
synthetic
polymer fibres, such as polypropylene, polyester, polyethylene, polyolefin,
polyamide polyethylene and polipropilen, high impact polystyrene and nylon
fibres; cellulosic nonwoven fibres such as nonwoven rayon; and combinations of
these materials.
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The term "thermoplastic" is used herein to refer to materials which are solid
at room
temperature, i.e. from 22 C. to 30 C., but which soften or melt when heated
to
temperatures above room temperature. Thermoplastic materials are extrudable at
temperatures in excess of 50 C. Preferred thermoplastic materials soften or
melt at
temperatures above about 50 C. and below about 1,000 C., in order that the
material will not melt during transportation but be melted by commonly-used
surgical lasers. More preferred thermoplastic materials soften or melt at
temperatures between 60 C. and 500 C. For surgical drape applications where
patient comfort is a factor, preferably at least 10 percent of the nonwoven
fibres
have lengths greater than about 0.06 cm.
Preferred nonwoven fabric sheets include a layer of polyethylene film
sandwiched
between two layers of nonwoven rayon, melt-blown polypropylene fabric; and a
combination of wood pulp and polyester fibres. Nonwovens are typically
manufactured by putting small fibres together in the form of a sheet or web,
and
then binding them either mechanically as in the case of felt, by interlocking
them
with serrated needles such that the inter-fibre friction results in a stronger
fabric,
with an adhesive; thermally; by applying binder, preferably in the form of
powder,
paste, or polymer melt, and then melting the binder onto the web by increasing
temperature.
The nonwoven fabric material may be a nonwoven web, paper, film, foam,
elastomeric material, which may be supplied with the antimicrobial
composition.
If the nonwoven fabric has a weblike structure, it may preferably be a
spunbond
web, meltblown web, bonded carded web, airlaid web, coform web, and/or
hydraulically entangled web.
Polymers suitable for making nonwoven webs include, for example, polyolefins,
polyesters, polyamides, polycarbonates, copolymers and blends thereof, etc.
Most
embodiments of the laminate of the present invention employ a nonwoven web
formed from olefin-based polymers, which are non-polar in nature. Suitable
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polyolefins include polyethylene, such as high density polyethylene, medium
density polyethylene, low density polyethylene, and linear low density
polyethylene; polypropylene, such as isotactic polypropylene, atactic
polypropylene, and syndiotactic polypropylene; polybutylene, such as poly(1-
butene) and poly(2-butene); polypentene, such as poly(1-pentene) and poly(2-
pentene); poly(3 -methyl-l-pentene); poly (4 -methyl-1 -pentene) ; and
copolymers
and blends thereof. Suitable copolymers include random and block copolymers
prepared from two or more different unsaturated olefin monomers, such as
ethylene/propylene and ethylene/butylene copolymers.
Such polymer(s) may preferably also contain additives, such as processing aids
to
impart desired properties to the fibres, residual amounts of carriers,
pigments or
colorants, and so forth.
If desired, the nonwoven fabric may have a multi-layer structure. Suitable
multi-
layered materials may include, for instance spunbond/meltblown/spunbond (SMS)
laminates and spunbond/meltblown (SM) laminates. Various examples of suitable
SMS laminates are described in U.S. Pat. No. 4,041,203, U.S. Pat. No.
5,213,881,
U.S. Pat. No. 5,464,688, U.S. Pat. No. 4,374,888 U.S. Pat. No. 5,169,706 and
U.S.
Pat. No. 4,766,029. Nonwoven fabric materials are usually made in at least two
steps. In a first step, fibres are cut to a few centimetres length, and then
dispersed
on a conveyor belt, where they are spread in a uniform web by a wetlaid
process or
by carding. Combining melt blown and spunbond fibres results in SM or SMS webs
nonwoven fabric materials, which are strong and offer the intrinsic benefits
of fine
fibres such as fine filtration, low pressure drop as used in face masks or
filters and
physical benefits such as acoustic insulation as used in dishwashers, for
instance
for disposable diaper and hygiene care products.
Melt blown non woven fibres are typically produced by extruding melted polymer
fibres through a spin net or die to form long thin fibres which are stretched
and
cooled by passing hot air over the fibres as they fall from the die. The
resultant web
is collected into rolls and subsequently converted to finished products. The
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extremely fine fibres typically differ from other in that they have low
intrinsic
strength but much smaller size offering.
Nonwoven fabrics are typically bonded by using either resin or thermally.
Bonding
can be throughout the web by resin saturation or overall thermal bonding or in
a
distinct pattern via resin printing or thermal spot bonding.
The nonwoven fabric may advantageously also contain additional fibrous
components. For example, a nonwoven fabric may be entangled with a fibrous
component using any of a variety of entanglement techniques known to a person
skilled in the art, such as cellulosic fibres or glass fibres. A typical
hydraulic
entangling process utilizes high pressure jet streams of water to entangle
fibres to
form a highly entangled consolidated fibrous structure, e.g., a nonwoven
fabric.
Fibreglass is wetlaid into mats for use in roofing and shingles. Synthetic
fibre
blends are wetlaid along with cellulose for single-use fabrics.
Other materials may also be used to form the nonwoven fabric material. For
example, the nonwoven fabric may contain an elastomeric polymer, such as
natural
rubber latex, isoprene polymers, chloroprene polymers, vinyl chloride
polymers,
styrene-ethylene-butylene-styrene block copolymers, styrene-isoprene-styrene
block copolymers, styrene-butadiene-styrene block copolymers, styrene-isoprene
block copolymers, styrene-butadiene block copolymers, butadiene polymers,
styrene-butadiene polymers, carboxylated styrene-butadiene polymers,
acrylonitrile-butadiene polymers, carboxylated acrylonitrile-butadiene
polymers,
acrylonitrile-styrene-butadiene polymers, carboxylated acrylonitrile-styrene-
butadiene polymers, derivatives thereof, and so forth. The fabric material may
optionally be treated with liquid-repellency additives, antistatic agents,
surfactants,
colorants, antifogging agents, fluorochemical blood or alcohol repellents,
and/or
lubricants.
The woven or non-woven fabric materials according to the present invention can
be
prepared particularly cheaply and in large economical scale with high
throughput
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processes, giving access to comparatively cheap antimicrobial products that
may be
employed for applications where prior to the invention the use of
antimicrobial
materials would have been unsuccessful due to the prohibitive costs involved.
The
antimicrobial composition may be tailored according to the use and potential
contamination targeted. The economics can be maintained due to the extremely
low
amounts of metal deposited. The metal layer has a high adhesion, while other
properties, such as flexibility of the substrate, remain unchanged.
Two different technologies are used in the introduction of the synthesis
material to
the structure of non-woven material. While the effect is achieved by immersion
method, but a shorter period of time is provided, in the case of entering the
material
during the production phase, the formation of longer periods than both
efficiency
and stability is ensured.
The subject woven and non-woven antimicrobial materials may advantageously be
employed in various applications to inhibit the growth of microorganisms. For
example, they may be used in treatments or surroundings where hospital-
acquired
infections caused by bacteria, viruses, fungi, or parasites. The subject woven
and
non-woven antimicrobial materials preferably have an antibacterial activity of
at
least 3, more preferably at least 4, yet more preferably at least 5 as
determined by
the ISO 20743:2007 method, using Staphylococcus aureus ATCC 6538 and/or
Klebsiella pneurnoniae ATCC 4352. This activity is advantageously measured on
the on the metalized surface as described herein below.
Antimicrobial woven and non-woven fabric materials according to the invention
may advantageously be employed in numerous applications, including: hygiene
articles, such as diapers, feminine hygiene articles, wet wipes, bandages,
facial
masks and wound dressings; medical isolation and/or surgical apparel and
gowns,
surgical drapes and covers, surgical scrub suits, masks, caps and generally
disposable clothing; filters for fluids and air, sensitive packaging materials
and so
on. These filters are typically employed in filtration and processing steps in
the
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pharmaceutical, chemical, food and mineral and oil processing industry, and
may
be formed into cartridge and bag filters, vacuum bags, and allergen membranes.
The present invention further also relates to a integrarted syhthezis material
to
woven or non-woven fabric material such as sheet cloth and its applications as
two
different technologies which are used in the introduction of the synthesis
material
to the structure of non-woven material, and while the effect is achieved by
immersion method, but a shorter period of time is provided, in the case of
entering
the material during the production phase, the formation of longer periods than
both
efficiency and stability is ensured. The effect is desirable in high quality
air
environments such as hospitals and health care facilities, but also public
spaces,
such as preferably public transport, e.g. underground trains, large office
buildings,
schools, housing and the like. The present invention further relates to a
filter
comprising the metallised non-woven material with bacterial growth suppressing
activity. The filter, and cartridges comprising the nonwoven fabric material
according to the invention may be employed for air and/or liquid filtration,
such as
for instance for drinking water. In the latter it may advantageously remove
smells,
discolouration and chemical contaminants such as chlorine besides its
antimicrobial
function. The antibacterial filter comprising material according to the
invention can
further positively reduce the microbial load, and hence impact air quality in
stand-
alone ventilation circuits in the automotive and aerospace industries.
The woven non-woven fabric may be used alone, or in combination with other
materials for a further spectrum of products with diverse properties, such as
components of apparel, home furnishings, health care, engineering, industrial
and
consumer goods. In addition, the (non)woven fabric material substrate may also
serve other purposes, such as providing water absorption, barrier properties,
etc.
Any of a variety of (non)woven fabric material substrates may be applied with
the
antimicrobial composition in accordance with the present invention.
Accordingly,
the present invention also relates to the use of the materials according to
the
invention, or those materials obtainable according to above described process,
for
the control or restriction of antimicrobial growth.
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Although several specific embodiments of the present invention have been
described in the detailed description above, this description is not intended
to limit
the invention to the particular form or embodiments disclosed herein since
they are
to be recognised as illustrative rather than restrictive, and it will be
obvious to those
skilled in the art that the invention is not limited to the examples
Nonwoven abrasive articles used for cleaning, such as nonwoven abrasive scrub
pads, can harbor microorganisms such as bacteria and fungi that can thrive and
rapidly multiply in moist environments. Consequently, it is desirable to use
materials that are effective at cleaning and that control or prevent the
growth of
unwanted microorganisms on nonwoven abrasive articles. Although various
approaches have been taken to try to solve the problem of microbial growth on
nonwoven abrasive articles used for cleaning, such approaches have not
produced
nonwoven abrasive articles that have long lasting effects on a broad spectrum
of
organisms
The nonwoven substrate can be of any desired weight. In a particular
embodiment,
the weight of the nonwoven substrate material per unit area can be in a range
of
about 100 GSM to 500 GSM, such as 150 GSM to 200 GSM, or about 160 GSM to
about 180 GSM (i.e., grams per square meter, or g/m2). Suitable nonwoven
substrates are comprised of fibers that are bound together by various methods
or
mechanisms, such as typically, by being sprayed with a binder formulation. A
suitable non-limiting binder composition is shown below in Table A of the
Examples. The nonwoven substrate material can have any desired suitable loft.
In
a specific embodiment the loft is 12-14 mm and a weight per unit area within a
range of 230-250 GSM. In accordance with an embodiment, the nonwoven
substrate material can include one or more binders to adhere and interlock the
threads (fibers) of the nonwoven web. In a particular embodiment, the binder
can
include natural or synthetic rubber latex, a large range of acrylic binder,
melamine
formaldehyde resin, or a combination thereof. The nonwoven substrate material
is
cured and complete prior to application of the first formulation or the second
formulation.
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In an embodiment, the nonwoven substrate material can have a particular
thickness.
Thickness can be defined as the minimum exterior dimension of the nonwoven
substrate material. In an embodiment, the nonwoven substrate material can have
a
thickness that is at least 1 mm, such as at least 5 mm, at least 10 mm, at
least 15
mm, at least 20 mm, or even at least 25 mm. In a non-limiting embodiment, the
nonwoven substrate material can have a thickness that is not greater than 100
mm,
such as not greater than 50 mm, or even not greater than 30 mm. It will be
appreciated that the nonwoven substrate material can have a thickness that is
within
a range of any minimum or maximum value noted above.
In an embodiment, the nonwoven substrate material can have a particular loft.
In an
embodiment, the nonwoven substrate material can have a loft of at least 5 mm,
such
as at least 8 mm, or at least 10 mm. In a non-limiting embodiment, the
nonwoven
substrate material can have a loft that is not greater than 35 mm, such as not
greater
than 30 mm, not greater than 20 mm, not greater than 15 mm, or even not
greater
than 12 mm. It will be appreciated that the nonwoven substrate material can
have a
loft that is within a range of any maximum or minimum value noted above, such
as
within a range of 8 mm to 14 mm.
In an embodiment, the nonwoven substrate material can have a particular weight
per unit area, defined as grams per square meter, or GSM. In an embodiment,
the
nonwoven substrate material can have a weight of at least 200 GSM, such as at
least
220 GSM, or at least 240 GSM. In a non-limiting embodiment, the nonwoven
substrate material can have a weight per unit area of not greater than 300
GSM,
such as not greater than 270 GSM, or even not greater than 250 GSM. It will be
appreciated that the nonwoven substrate material can have a weight per unit
area
within a range of any minimum or maximum value noted above, such as within a
range of 240 GSM to 250 GSM.
In accordance with an embodiment, the abrasive article provides abrasive
performance and broad spectrum antimicrobial effectiveness against S. aureus,
and
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one or more of K. pneurnoniae, Bacillus, and E. coli as defined above with
respect
to the first antimicrobial agent.
Surprisingly, the broad spectrum antimicrobial effectiveness lasts over an
extended
period of time and/or extensive usage of the abrasive article. In an
embodiment, the
abrasive article possesses broad spectrum effectiveness even after extensive
usage,
such as even after completing 5000 cycles according to the Cyclic Abrasion
Test,
which equates to cleaning approximately 500 utensils or approximately 15 days
of
cleaning with the abrasive article. The Cyclic Abrasion Test is described in
greater
detail below in the Examples. Further, the abrasive article possesses broad
spectrum
effectiveness even after being subjected to three hours of ball milling
according to
the Accelerated Life Test, which is described in greater detail below in the
Examples.
In an embodiment, the abrasive article can have a particular weight, defined
as
grams per square meter, or GSM. In an embodiment, the abrasive article can
have
a weight of at least at least 300 GSM, at least 500 GSM, at least 750 GSM, at
least
850 GSM, or at least 1050 GSM. In a non-limiting embodiment, the abrasive
article
can have a weight of not greater than 3000 GSM, such as not greater than 2000
GSM, not greater than 1500 GSM, or not greater than 1300 GSM. It will be
appreciated that the abrasive article can have a weight within a range of any
minimum or maximum value noted above, such as within a range of 300 GSM to
3000 GSM. IN a particular embodiment, the abrasive can have a weight per unit
area within a range of 1050 GSM to 1150 GSM.
The completed abrasive article can have a particular measure of nonwoven
substrate
material compared to the total weight of the abrasive article (which includes
the
combined amount of cured first formulation and cured second formulation
disposed
on and in the nonwoven substrate material). In accordance with an embodiment,
the
abrasive article can have a GSM-ratio of the weight of the nonwoven substrate
material prior to being impregnated and sprayed with the first ad second
formulation (GSMnonwoven) to the weight of the final cured abrasive article
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(GSMfing). In an embodiment, the abrasive article can have a GSM ratio (i.e.,
GSMnonwoven:GSMfinal) of at least 1:2, meaning that the weight in GSM of the
final
cured abrasive article has at least twice a much weight as the nonwoven
substrate
material from which it was formed. In an embodiment, the GSMratio can be at
least
1:3, at least 1:4, or at least 1:5. In a non-limiting embodiment, the GSMratio
can be
not greater than 1:15, such as not greater than 1:6, or not greater than 1:5.
It will be
appreciated that the GSMratio can be within a range of any minimum or maximum
value noted above. In a particular embodiment, the GSMratio can be within a
range
of 1:3 to 1:6, and more particularly within a range of 1:4 to 1:5.
Breast surgery may be undertaken for any of a number of reasons. A mastectomy
(surgical removal of the breast) may be required to remove breast cancer. A
biopsy
such as an open excisional biopsy (lumpectomy) or needle aspiration may be
used
to obtain a sample of a suspected tumor for analysis. Mastopexy (breast lift)
or
breast augmentation may be undertaken for cosmetic reasons. Mammoplasty
(breast reduction) may be undertaken for cosmetic reasons or to treat physical
symptoms. Reconstructive surgery may restore the contour of a breast after
accident
or other surgery, or may be used to amend the contour of a healthy breast to
match
the contour of a breast changed by other surgery. As in all surgeries,
surgeries of
the breast share the characteristic that an incision or a penetration of the
skin
overlying the breast is required. As in all surgeries, surgeries of the breast
involve
a risk that bacteria or other infectious agents may travel through the skin
penetration
and cause an infection.
The control of microbes on the undergarments of a post-surgery patient, such
as a
brassiere of a breast surgery patient, helps to reduce infection and to
improve the
emotional well-being of the patient. A brassiere is worn continuously for many
hours, providing a relatively warm, relatively moist environment in which
microbes
may multiply. The problem posed by microbes is exacerbated in the case of the
post-operative breast surgery patient due to the fact that tenderness and loss
of arm
strength or mobility resulting from the breast surgery may make maintaining a
high
degree of personal cleanliness difficult for the patient. The control of
microbes in
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the brassiere of a post-breast surgery patient further helps to prevent
anxiety and to
maintain the emotional well being of the patient by preventing odors or
discoloration resulting from the presence of the microbes
Thus there is a need for antimicrobials that are safe, non-toxic, long-lasting
and
effective at controlling contamination and infection by unwanted microbial
organisms, with minimal development of resistant or polyresistant
microorganisms.
In one aspect, the present invention relates to novel, antimicrobial polymers.
In
another aspect, the present invention relates to antimicrobial pharmaceutical
compositions and methods for treatment of microbial infections in a mammal.
In another aspect, the present invention relates to antimicrobial
pharmaceutical
compositions and methods for wound management.
In another aspect, the present invention relates to antimi crobial
pharmaceutical
compositions and methods for treatment of infections of the skin, oral mucosa
and
gastrointestinal tract.
In yet another aspect, the present invention relates to antimicrobial
compositions
and methods of preventing, inhibiting, or eliminating the growth,
dissemination and
accumulation of microorganisms on susceptible surfaces, particularly in a
health-
related environment.
The ionene polymers and compositions of the invention are also particularly
useful
for inhibiting the growth and dissemination, of microorganisms, particularly
on
surfaces wherein such growth is undesirable. The term "inhibiting the growth
of
microorganisms" means that the growth, dissemination, accumulation, and/or the
attachment, e.g. to a susceptible surface, of one or more microorganisms is
impaired, retarded, eliminated or prevented. In a preferred embodiment, the
antimicrobial compositions of the inventtions are used in methods for
inhibiting the
growth of an organism on susceptible surfaces in health-related environments.
The
term "health-related environment" as used herein includes all those
environments
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where activities are carried out directly or indirectly, that are implicated
in the
restoration or maintenance of human health. A health-related environment can
be a
medical environment, where activities are carried out to restore human health.
An
operating room, a doctor's office, a hospital room, and a factory making
medical
equipment are all examples of health-related environments. Other health-
related
environments can include industrial or residential sites where activities
pertaining
to human health are carried out such as activities including food processing,
water
purification, recreational water maintenance, and sanitation.
The term "susceptible surface" as used herein refers to any surface whether in
an
industrial or medical setting, that provides an interface between an object
and the
fluid. A surface, as understood herein further provides a plane whose
mechanical
structure, without further treatment, is compatible with the adherence of
microorganisms. Microbial growth and/or biofilm formation with health
implications can involve those surfaces in all health-related environments.
Such
surfaces include, but are not limited to, scalpels, needles, scissors and
other devices
used in invasive surgical, therapeutic or diagnostic procedures; implantable
medical
devices, including artificial blood vessels, catheters and other devices for
the
removal or delivery of fluids to patients, artificial hearts, artificial
kidneys,
orthopedic pins, plates and implants; catheters and other tubes (including
urological
and biliary tubes, endotracheal tubes, peripherally insertable central venous
catheters, dialysis catheters, long term tunneled central venous catheters,
peripheral
venous catheters, pulmonary catheters, Swan-Ganz catheters, urinary catheters,
peritoneal catheters), urinary devices (including long term urinary devices,
tissue
bonding urinary devices, artificial urinary sphincters, urinary dilators),
shunts
(including ventricular or arterio-venous shunts); prostheses, (including
breast
implants, penile prostheses, vascular grafting prostheses, heart valves,
artificial
joints, artificial larynxes, otological implants), vascular catheter ports,
wound drain
tubes, hydrocephalus shunts, pacemakers and implantable defibrillators, and
the
like.
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Other surfaces include the inner and outer surfaces of pieces of medical
equipment,
medical gear worn or carried by personnel in the health care settings and
protective
clothing for biohazard or biological warfare applications. Such surfaces can
include
counter tops and fixtures in areas used for medical procedures or for
preparing
medical apparatus, tubes and canisters used in respiratory treatments,
including the
administration of oxygen, solubilized drugs in nebulizers, and anesthetic
agents.
Additional surfaces include those surfaces intended as biological barriers to
infectious organisms such as gloves, aprons and faceshields.
Surfaces in contact with liquids are particularly prone to microbial growth
and/or
biofilm formation. As an example, those reservoirs and tubes used for
delivering
humidified oxygen to patients can bear biofilms inhabited by infectious
agents.
Dental unit waterlines similarly can bear biofilms on their surfaces,
providing a
reservoir for continuing contami nation of the system of flowing and
aerosolized
water used in dentistry.
Other surfaces related to health include the inner and outer surfaces of
equipment
used in water purification, water storage and water delivery, and those
articles
involved in food processing equipment for home use, materials for infant care
and
toilet bowls.
In accordance with the invention, a method for preventing, inhibiting or
eliminating
the growth, dissemination and/or accumulation of microorganisms on a
susceptible
surface (including but not limited to the formation of biofilms) comprises the
step
of contacting such surface with an antimicrobial agent, or composition thereof
of
the invention, with an amount sufficient to prevent, inhibit or eliminate such
growth, dissemination and/or accumulation, i.e., with an effective amount.
In some embodiments, the antimicrobial agent of the invention is an
antimicrobial
preservative, attesting to the ability of the formulations of the invention to
suppress
microbial growth, reduce microbial infestation, treat products or surfaces to
improve product resistance to microbial infestation, reduce biofilm, prevent
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conversion of bacteria to biofilm, prevent or inhibit microbial infection,
prevent
spoilage, retard or minimize or prevent quorum sensing, and retard microbial
reproduction.
The antimicrobial agent is capable of endowing a product, or the product
surface,
with a biological resistance to at least one biological effect, which in the
absence of
such agent would eventually bring about a short-term or long-term damage to
the
product. In the context of the invention, the antimicrobial agent improves the
product's resistance to a certain environmental condition. In some
embodiments,
the resistance to such a condition is resistance to biofouling.
In some embodiments, the microorganism is a bacteria, being selected, in some
embodiments from Bordetella pertussis, Borrelia burgdorferi. Bruce ha abortus.
Brucella canis. Brucella melitensis. Brucella suis, Campylobacter jejuni.
Chlamydia pneumonia. Chlamydia psittaci. Chlamydia trachomatis, Clostridium
botulinum Clostridium difficile, Clostridium perfringens, Clostridium tetani,
Corynebacterium diphtheria. Enterococcus faecalis. Enterococcus faecium,
Escherichia coil (E. coli), Enterotoxigenic Escherichia coli (ETEC),
Enteropathogenic E. coli, Erancisella tularensis, Haemophilus influenza,
Helicobacter pylon, Legionella pneumophila, Leptospira interrogans. Listeria
monocyto genes, Mycobacterium leprae, Mycobacterium tuberculosis. Mycoplasma
pneumonia. Neisseria gonorrhoeae. Neisseria meningitidis. Pseudomonas
aeruginosa, Rickettsia rickettsii. Salmonella typhi. Salmonella typhimurium.
Shigella sonnei. Staphylococcus epidermidis. Staphylococcus saprophyticus.
Streptococcus agalactiae. Streptococcus mutans Streptococcus pneumonia.
Streptococcus pyo genes. Treponema pallidum. Vibrio cholera, Vibrio harveyi
and
Yersinia pestis.
In other embodiments, the microorganism is a fungus, selected in some
embodiments from Absidia corymbifera, Ajellomyces capsulatus, Ajellomyces
dermatitidis, Arthroderma benhamiae, Arthroderma fulvum, Arthroderma
gypseum, Arthroderma incurvatum, Arthroderma otae, Arthroderma
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vanbreuseghemii, Aspergillus flavus, Aspergillus fumigates, Aspergillus niger,
Blastomyces dermatitidis, Candida albicans, Candida albicans var.
stellatoidea,
Candida dublinensis, Candida glabrata, Candida guilliermondii, Candida krusei,
Candida parapsilosis, Candida pelliculosa, Candida tropicalis,
Cladophialophora
carrionii, Coccidioides immitis. Cryptococcus neoformans, Cunninghamella sp.,
Epidermophyton floccosum, Exophiala dermatitidis, Eilobasidiella neoformans,
Eonsecaea pedrosoi. Geotrichum candidum, Histoplasma capsulatum, Hortaea
wemeckii, Issatschenkia orientalis, Madurella grisae, Malassezia furfur,
Malassezia furfur complex, Malassezia globosa, Malassezia obtuse, Malassezia
pachydermatis, Malassezia restricta, Malassezia slooffiae, Malassezia
sympodialis, Microsporum canis, Microsporum fulvum, Microsporum gypseum,
Microsporum gypseum complex, Microsporum gypseum, Mucor circinelloides,
Nectria haematococca, Paecilomyces variotii, Paracoccidioides brasiliensis,
Penicillium mameffei, Phialophora verrucosa, Pichia anomala, Pichia
guilliermondii, Pneumocystis jirovecii, Pseudallescheria boydii, Rhizopus
oryzae,
Rodotorula rubra, Saccharomyces cerevisiae, Scedosporium apiospermum,
Schizophyllum commune, Sporothrix schenckii, Stachybotrys chartarum.
Trichophyton mentagrophytes. Trichophyton
mentagrophytes complex.
Trichophyton mentagrophytes. Trichophyton mentagrophytes. Trichophyton
rubrum. Trichophyton tonsurans.
As used herein, the term "dry fogging", or any lingual variation thereof,
refers to
the bringing together of the liquid to be treated (e.g., water) and the
antimicrobial
agent embedded or air diffusion and surface coated onto at least a part of the
product's surface in such a way to allow elimination of organisms within the
air and
contaminated surface. Yet a further aspect provides a method for preventing
growth
of bacteria on a surface being in contact with dry fogging or dricetly sprayed
the
surface for at least a period of time, the method comprising incorporating the
antimicrobial agent of the invention onto said surface. In some embodiments,
the
product's surface is surface coated with the antimicrobial agent as described
herein.
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The antimicrobial agents are present material impart the antimicrobial
properties to
the substrate. The surface may be associated with the surface in any way,
e.g..
Vander Waals forces, ionic bonding, hydrogen bonding, or through a coating
linker
such as a glue, forming stable coatings that exhibits minimal or no
degradation or
leaching, e.g.,when exposed to an aqueous medium. As such, the dry fogging
comprising the antimicrobial agents in accordance with the invention are safe
for
use in a variety of monthly applications.
The dry fogging substrates according to the invention may be used for (a)
reducing
or preventing bacterial infection without the need to use drug materials e.g.,
antibiotics, to the end product, the substrates may be any region of a storage
container or a delivery system for use in food packaging, food and beverage
containers, food and beverage preparation or disposing equipment, blood bags,
proteins or pharmaceuticals. Alternatively, the antimicrobial agents of the
invention
may be used in the construction of a personal product or an industrial product
such
as devices used in sporting activities, orthodontic devices, face or breathing
masks,
pacifiers, contact lenses, adult products, food preparation surfaces, food
packaging,
surface, air, textile, paint, plastic, silicone and wood, polyethylene, metals
and
derivatives reusable water containers, hydration systems, water bottles,
computer
keyboards, telephones, rental car steering wheels, health club equipment,
whirlpool
spas and humidifiers to provide antimicrobial properties.
To evaluate the bactericidal efficiency of combination polymeric guanidine
derivative based on a diamine containing oxyalkylene chains between two amino
groups, with the guanidine derivative representing a product of
polycondensation
between a guanidine acid addition salt and a diamine containing
polyoxyalkylene
chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine)
guanidinium derivatives, particularly to combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as
an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
(Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants
29
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like humic acids and some natural products like phytotherapeutic plant
extracts for
the production of a liqid, powder and tablette form for antimicrobial activity
bactericidal efficiency was assessed for
Antimicrobial activity:
HPP plates with 0.5% and 5% w/w of synthesis material from obtained
combination
polymeric guanidine derivative based on a diamine containing oxyalkylene
chains
between two amino groups, with the guanidine derivative representing a product
of
polycondensation between a guanidine acid addition salt and a diamine
containing
polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-
hexanediamine) guanidinium derivatives, particularly to combinations of
oligo(2-
(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene
guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine
guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148),
Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino
acids, antioxidants like humic acids were obtained by injection of the
mixture. The
mixtures were tested for virucidal and bactericidal efficacy against the E.
coli
bacteria by immersing samples in bacterial suspensions for predetermined
period
of time. The microorganisms used to assess biological activity are given in
Table 1.
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Table 1. The microorganisms used to assess biological activity
(Product name/ID) synthesis product
(working date) 24.10 .2018
(Storage temperature) 25 C
(Sample concentration) Kontrol, 0,5%, 2%, 5%
(working temperature) 25 C
(Incubation temperature) 30-37 C
(Interfering substances) FCS
Aqua Distilled Control
Logarit
mik
Azalma
Temas Son Sayim (Kob/ml
ilk Sayim (Kob/ml)
Siiresi (Kob/ml) )
Strains Spayk First count cfu/ml
(Dakik Final count cfu/ml Log
Meto (Kob/ (log NO)
a) (log Na) Reducti
t ml)
Conta on
Meth Spike
ct cfu/ml
od (cfu/ml
Time (logR)
) (Minut Logi.
e) TC2 TC2 0
TC1 TC1 Ort
Bacteria (VC2 (VC2 Ort
(VC1) (VC1) (med)
) ) (med
)
IN
HOUS 1,6E 2,1E 8,3E 0,0
S.aureus E 2,2E+8 5 2,6E+8 2,1E+8 8,3E+0 +8 +8 +0
IN
P.aerugin HOUS 3,3E 3,5E 8,6E 0,0
0.501 E 4,6E+8 5 3,9E+8 3,1E+8 8,6E+0 +8 +8 +0
IN
HOUS 3,90E+ 4,6E 3,3E 8,6E 0,0
E.hirae E 4,6E+8 5 3,3E+8 8 8,6E+0 +8 +8 +0
IN
HOUS 2,1E 3,5E 8,5E 0,0
E.coli E 6,2E+8 5 3,9E+8 3,3E+8 8,4E+0 +8 +8 +0
5% synthesis product
Logarit
Temas
Spayk mik
Siiresi
Meto (Kob/ Son Sayim Azalma
(Dakik ilk Sayim (Kob/ml)
t ml) (Kob/ml) (Kob/ml
Strains a) First count cfu/ml
Meth Spike Final count cfu/ml )
Conta (log NO)
od (cfu/ml (log Na) Log
ct
) Reducti
Time
on
31
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(Minut cfu/ml
e) (logR)
Logi.
TC2 TC2 0
TC1 TC1 Ort
Bacteria (VC2 (VC2 Ort
(VC1) (VC1) (med)
) ) (med
)
IN
HOUS 1,0E 1,0E
0,0E 7,0
S.aureus E 2,2E+8 5 1,5E+7 6,0E+6 7,0E+0 +0 +0 +0
IN
P.aerugin HOUS 1,0E 1,0E
0,0E 7,2
0.501 E 4,6E+8 5 2,0E+7 1,4E+7 7,2E+0 +0 +0 +0
IN
HOUS 1,0E 1,0E
0,0E 7,5
E.hirae E 4,6E+8 5 1,0E+7 5,6E+7 7,5E+0 +0 +0 +0
IN
HOUS 1,0E 1,0E
0,0E 7,6
E.coli E 6,2E+8 5 3,2E+7 4,3E+7 7,6E+0 +0 +0 +0
0.5% synthesis product
Logarit
mik
Azalma
Temas Son Sam (Kob/ml
ilk Sam (Kob/ml)
Siiresi (Kob/ml) )
Strains Spayk First count cfu/ml
(Dakik Final count cfu/ml Log
Meto (Kob/ (log NO)
a) (log Na) Reducti
t ml)
Conta on
Meth Spike
ct cfu/ml
od (cfu/ml
Time ______________________________________________________________ (logR)
) (Minut Logi.
e) TC2 TC2 0
TC1 TC1 Ort
Bacteria (VC2 (VC2 Ort
(VC1) (VC1) (med)
) ) (med
)
IN
HOUS 1,1E 9,8E
4,0E 3.4
S.aureus E 2,4E+8 5 2,1E+7 1,8E+7 7,4E+0 +4 +4 +0
IN
P.aerugin HOUS 7,1E 8,7E
4,7E 2,6
0.501 E 4,3E+8 5 1,1E+7 1,2E+7 7,3E+0 +4 +4 +0
IN
HOUS 6,3E 8,6E
4,7E 3.0
E.hirae E 4,8E+8 5 3,0E+7 4,8E+7 7,7E+0 +4 +4 +0
IN
HOUS 2,2E 7,0E
4,6E 2,9
E.coli E 6,3E+8 5 3,3E+7 3,0E+7 7,5E+0 +4 +4 +0
32
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2% synthesis product .
Logarit
Temas ilk Son
mik
Siiresi Sayim Sayim
Spayk Azalma
(Dakik (Kob/ (Kob/
Meto (Kob/ (Kob/ml
a) ml) ml)
t ml) )
Conta First Final
Strains Meth Spike Log
ct count count
od (cfu/ml Reducti
Time cfu/ml cfu/ml
) on
(Minut (log (log
cfu/ml
e) NO) Na)
(logR)
Log1
TC2 TC2 0
Bakteri TC1 TC1 Ort
(VC2 (VC2 Ort
Bacteria (VC1) (VC1) (med)
) ) (med
)
IN
HOUS 1,0E 1,0E 1,2E 5,8
S.aureus E 2,4E+8 5 2,4E+7 3,0E+6
7,0E+0 +2 +2 +0
IN
P.aerugin HOUS 1,0E 1,0E 1,5E 5,7
0.501 E 4,3E+8 5 3,5E+7 1,4E+7
7,2E+0 +2 +2 +0
IN
HOUS 1,0E 1,0E 1,1E 5,8
E.hirae E 4,8E+8 5 2,5E+7 4,6E+7
7,5E+0 +2 +2 +0
_
IN
HOUS 1,0E 1,0E 1,3E 6,3
E.coli E 6,3E+8 5 3,1E+7 4,3E+7
7,6E+0 +2 +2 +0
/Aqua Distilled Control
Logarit
mik
Azalma
Temas Son Sayim (Kob/ml
ilk Sayim (Kob/ml)
Siiresi (Kob/ml) )
Spayk First count cfu/ml
Strains (Dakik Final count cfu/ml Log
Meto (Kob/ (log NO)
a) (log Na) Reducti
t ml)
Conta on
Meth Spike
ct cfu/ml
od (cfu/ml
Time (logR)
) (Minut Log1
e) TC2 TC2 0
Yeast/mol TC1 TC1 Ort
(VC2 (VC2 Ort
d (VC1) (VC1) (med)
) ) (med
)
33
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IN
HOUS 1,8E 2,0E
6,3E 0
C.albicans E 4,3E+7 60 1,6E+6
2,6E+6 6,3E+0 +6 +6 +0
IN
HOUS 3,5E 6,3E
6,7E 0
A.niger E 5,1E+7 60 3,6E+6
6,6E+6 6,7E+0 +6 +6 +0
5% synthesis product
Logarit
mik
Azalma
Temas Son Sayim (Kob/ml
ilk Sayim (Kob/ml)
Siiresi (Kob/ml) )
Spayk First count cfu/ml
(Dakik Final count
cfu/ml Log
Meto (Kob/ (log NO)
a) (log Na) Reducti
t ml)
Yeast/mol Conta on
Meth Spike
d ct cfu/ml
od (cfu/ml
Time (logR)
) (Minut Log1
e) TC2 TC2 0
TC1 TC1 Ort
(VC2 (VC2 Ort
(VC1) (VC1) (med)
) ) (med
)
IN 6,2
HOUS 1,0E 1,0E 0,0E
C.albicans E 4,3E+7 60 1,3E+6
1,6E+6 6,2E+0 +0 +0 +0
IN
HOUS 1,0E 1,0E
0,0E 6,3
A.niger E 5,1E+7 60 1,6E+6
2,6E+6 6,3E+0 +0 +0 +0
Logarit
mik
Azalma
Temas Son Sayim (Kob/ml
ilk Sayim (Kob/ml)
Siiresi (Kob/ml) )
Spayk First count cfu/ml
(Dakik Final count
cfu/ml Log
Meto (Kob/ (log NO)
a) (log Na) Reducti
Yeast/mol t ml)
Conta on
d Meth Spike
ct cfu/ml
od (cfu/ml
Time (logR)
) (Minut Log1
e) TC2 TC2 0
TC1 TC1 Ort
(VC2 (VC2 Ort
(VC1) (VC1) (med)
) ) (med
)
34
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0.5% synthesis product
IN
HOUS 1,0E 3,0E 2,6E 3,7
C.albicans E 4,3E+7 60 5,1E+6 5,6E+6 6,3E+0 +2 +2 +0
IN
HOUS 1,2E 2,1E 3,8E 3,8
A.niger E 5,1E+7 60 4,2E+6 4,1E+6 6,1E+0 +3 +3 +0
2% synthesis product
IN
HOUS 2,0E 3,3E 1,1E 5,3
C.albicans E 4,3E+7 60 3,2E+6 4,1E+6 6,4E+0 +1 +1 +0
IN
HOUS 2,3E 2,2E 1,2E 5,1
A.niger E 5,1E+7 60 5,8E+6 3,2E+6 6,3E+0 +2 +2 +0
Containing polyoxyalkylene chains between two amino groups,
Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly
to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride),
modified
polyhexamethylene guanidine (PHMG) as an antimicrobial agent.,
poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives
(JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA)
enzymes, PGPR, amino acids, antioxidants like humic acids are found to be very
effective on antibacterial agent woven, nonwoven-coton blended fabric material
having antimicrobial activity, and to its uses ranging from wound dressing,
facial
masks, surgical drapes and surgical clothing, to filter materials, panty, bra,
handkerchief, pad, scouring padõ disposable sheets and similar applications.
The
gram-negative bacterial pathogens Escherichia Coli, Enterobacter sakazakii,
Salmonella, pseudomonas, escheria coli, entereobacter aerogenes, coliform,
legionalla, and Campylobacter and in particular against Salmonella
typhimurium,
Salmonella enteriditis, Escherichia Coli 0157:H7 and Campylobacter jejuni are
often found in these types of applications. The use of combinations of oligo(2
-(2-
ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine
guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes,
PGPR, amino acids, antioxidants such as humic acids and some natural products
like phytotherapeutic plant extracts as antibacterial agent is found to be
effective
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against said bacteria without loss of taste and without loss of texture both
directly
application and and/or contamination using antimicrobial surface of touch
surface
such as polyethylene, metal, plastic. Furthermore, the above-mentioned methods
and alternative processing techniques as e.g. heat treatment for preservation
do not
prevent food poisoning as consequences of temperature-abuse and/or
contamination. Examples of fresh and dry vegetable, fruit and fresh meat are
beef,
beef steak, beef oxtails, neckbones, short ribs, beef roasts, stew meat, beef
briskets,
pork, pork chops, por steaks, cutlets, pork roasts, lamb, veal, game goat,
filet
americain, steak tartar, sushi, or carpaccio, chicken, turkey, duck and other
poultry
directly and/or contamination using antimicrobial surface of touch surface
such as
polyethylene, metal, plastic. Some of these fresh meat applications are to be
consumed raw, while others are consumed after application of only partial heat
treatment, intentionally applied as e.g. for medium cooked steak or
unintentionally
applied due to improper preparation or improper handling of the food products.
The
use of containing polyoxyalkylene chains between two amino groups,
Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly
to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride),
modified
polyhexamethylene guanidine (PHMG) as an antimicrobial agent.,
poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives
(JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA)
enzymes, PGPR, amino acids, antioxidants like humic acids as antibacterial
agent
ensures food safety even in the case of partial heat-treatment. The
antibacterial
activity not only includes bacteriostatic activity preventing further
bacterial growth
but also includes for some bacteria bacteriocidal activity that actually
reduces the
bacterial number. containing polyoxyalkylene chains between two amino groups,
Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives, particularly
to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride),
modified
polyhexamethylene guanidine (PHMG) as an antimicrobial agent.,
poly(hexamethylendiamine guanidinium chloride), Polietheramine derivatives
(JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine (TEGDA)
enzymes, PGPR, amino acids, antioxidants like humic acids of 0.5 to 2 wt%
based
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on total weight of product were found to be effective as antibacterial agent
for
escheria coli, entereobacter aerogenes, coliform, legionalla and glycine
concentrations of 0.5 to 1.8 wt% based on total weight of product were found
to be
suited in ensuring taste of the product. Combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride),
polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids,
antioxidants such as humic acids and some natural products like
phytotherapeutic
plant extracts concentrations of 0.25 to 2 wt% based on total weight of
product were
found to be effective as antibacterial agent for E. Sakazakii and containing
polyoxyalkylene chains between two amino groups, Hexamethylenediamine (1,6-
hexanediamine) guanidinium derivatives, particularly to combinations of
oligo(2-
(2-ethoxy)ethoxy ethyl guanidinium chloride), modified polyhexamethylene
guanidine (PHMG) as an antimicrobial agent., poly(hexamethylendiamine
guanidinium chloride), Polietheramine derivatives (JEFFAMINE EDR-148),
Polietheramine (Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino
acids, antioxidants like humic acids of 0.5 to 1.5 wt% based on total weight
of
product were found to be suited in ensuring taste of the product.
Combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride),
poly(hexamethylendiamine guanidinium chloride),
polyetheramines,
triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as
humic acids and some natural products like phytotherapeutic plant extracts
concentrations of 0.2 to 3 wt% based on total weight of product show
antibacterial
activity against Salmonella, and in particular Salmonella typhimurium and
Salmonella enteriditis. Combinations of oligo(2-(2-ethoxy)ethoxy ethyl
guanidinium chloride), poly(hexamethylendiamine guanidinium chloride),
polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids,
antioxidants such as humic acids and some natural products like
phytotherapeutic
plant extracts concentrations of 0.2 to 1.5 wt% based on total weight of
product
were found to be suited in ensuring taste of the product. Tests showed that a
concentration of about 1 to 1.8 wt% of combinations of oligo(2-(2-
ethoxy)ethoxy
37
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ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride),
polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids,
antioxidants such as humic acids and some natural products like
phytotherapeutic
plant extracts based on total weight of product starts to affect the taste of
said
product. In said product no auxiliary antibacterial agents and no other taste
affecting
ingredients were present. A combinations of oligo(2-(2-ethoxy)ethoxy ethyl
guanidinium chloride), poly(hexamethylendiamine guanidinium chloride),
polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids,
antioxidants such as humic acids and some natural products like
phytotherapeutic
plant extracts concentration above 1.5 wt% based on total weight of the
product
gives the product a sweet taste. Dependent on the type of product this sweet
taste is
acceptable or not. In sweet drinks for example the sweetening effect of
guanidium
is not considered a problem. Accordingly the maximally acceptable combinations
of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium
chloride),
poly(hexamethylendiamine guanidinium chloride), polyetheramines,
triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as
humic acids and some natural products like phytotherapeutic plant extracts
concentration in terms of not negatively affecting taste can be increased to
concentrations above 1.8 wt% guanidium based on total weight of the product.
Further, dependent on the presence of other taste affecting ingredients in the
product
as for example masking agents, the maximum concentration of combinations of
oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride), poly(hexamethylendiamine
guanidinium chloride), polyetheramines, triethyleneglycol diamine, enzymes,
PGPR, amino acids, antioxidants such as humic acids and some natural products
like phytotherapeutic plant extracts can also be increased up to a point at
which the
taste starts to be negatively affected by the presence of gundium derivative.
It was
found that the use of guanidium and/or its derivatives according to the
invention as
antibacterial agent in refrigerated foods and refrigerated drinks may be
combined
with one or more combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium
chloride), poly(hexamethylendiamine guanidinium chloride), polyetheramines,
38
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triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as
humic acids and some natural products like phytotherapeutic plant extracts.
SUMMARY OF THE INVENTION
The object of the present invention is to provide a highly effective universal
disinfecting, antiseptic and bactericidal, fungicidal or virucidal
composition, which
is useful in a broad range of positive and negative temperatures and in
increasing
the term of microbiocidal and disinfectant action. A further objective of the
invention is to enhance the length of time of the microbiocidal or
disinfectant action.
The present invention relates to woven, nonwoven
-coton blended fabric material having antimicrobial activity, and to its uses
ranging
from wound dressing, facial masks, surgical drapes and surgical clothing, to
filter
materials, panty, bra, handkerchief, pad, scouring padõ disposable sheets and
similar applications where the antimicrobial effects are employed, as well as
to a
process for the preparation of the woven, nonwoven, cotton, nonwoven- cotton
blended, polyethylene and polipropilen and polystyrene fabric material. The
present invention relates to a combination polymeric guanidine derivative
based on
a diamine containing oxyalkylene chains between two amino groups, with the
guanidine derivative representing a product of polycondensation between a
guanidine acid addition salt and a diamine containing polyoxyalkylene chains
between two amino groups, Hexamethylenediamine ( 1,6 -hexanediamine)
guanidinium derivatives, particularly to combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as
an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
(Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants
like humic acids and some natural products like phytotherapeutic plant
extracts for
the production of a liqid, powder and tablette form for antimicrobial
activity. The
present antimicrobial and anti-sporicidal compositions are useful in a wide
variety
of utility areas. These compositions are useful as topical applications in the
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treatment of microbiocidal infections in a subject. Applicants' compositions
can be
applied to various surfaces and when so applied these compositions serve as
sterilizers or sanitizers. Similarly, the present compositions can be used in
application areas such as, for example, synthetic surface preservative such as
the
prevention of microfloral growth on surfaces such as polymers, plastics or
poliethylne, ploprophylene, as a hard surface or carpet sanitizer. These
compositions are generally useful in controlling and/or elimination of
microflora
and spores in many industrial, medical, agricultural, veterinary and domestic
applications. Additionally, the present compositions can be employed to
sterilize or
disinfect gaseous environments including, for example, the cleansing of the
atmosphere in homes and industrial sites, as well as airplanes, etc.
In accordance with these and other aspects, the present invention provides
novel
ionene polymers having antimi- crobial activity. "combination polymeric
guanidine
derivative based on a diamine containing oxyalkylene chains between two amino
groups, with the guanidine derivative representing a product of
polycondensation
between a guanidine acid addition salt and a diamine containing
polyoxyalkylene
chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine)
guanidinium derivatives, particularly to combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as
an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
(Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants
like humic acids and some natural products like phytotherapeutic plant
extracts" or
"synthesis product," as used in the present invention, are cationic polymers
or
copolymers with amine groups in the main polymeric chain or backbone of the
polymer, providing a positive charge. The synthesis of this invention have
been
found to be non-irritating and low in toxicity to warm-blooded animals. The
present
invention also provides antimicrobial compositions comprising synthesis
product
and methods for treating microbial infections in mammals comprising the step
of
administering to a mammal, a therapeutically effective amount of at least one
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antimicrobial composition of the invention. The present invention further
provides
antimicrobial compositions comprising at least one synthesis and methods for
preventing, inhibiting or eliminating the growth, dissemination, and/or the
accumulation of microorganisms on a susceptible surface such as surface, air,
textile, paint, plastic, silicone and wood, polyethylene and derivatives.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to methods for the protection relates to woven,
nonwoven, cotton, nonwoven- cotton blended, polyethylene and polipropilen and
polystyrene fabric material having antimicrobial activity, and to its uses
ranging
from wound dressing, facial masks, surgical drapes and surgical clothing, to
filter
materials and similar applications where the antimicrobial effects are
employed, as
well as to a process for the preparation of the woven or nonwoven fabric
material
have been treated before consum with combinations of oligo(2-(2-ethoxy)ethoxy
ethyl guanidinium chloride), poly(hexamethylendiamine guanidinium chloride),
polyetheramines, triethyleneglycol diamine, enzymes, PGPR, amino acids,
antioxidants such as humic acids and some natural products like
phytotherapeutic
plant extracts.
woven, nonwoven, cotton, nonwoven- cotton blended, polyethylene and
polipropilen and polystyrene fabric material protecting agent composition
having a
pH of between 5.5 and 7.5 containing at least 0.5%, preferably at least 5% of
a
combination food protecting agent and guanidinium derivatives, particularly to
combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium chloride),
poly(hexamethylendiamine guanidinium chloride),
polyetheramines,
triethyleneglycol diamine, enzymes, PGPR, amino acids, antioxidants such as
humic acids and some natural products like phytotherapeutic plant extracts.
The present invention also relates generally to hard surface cleaning wipes
and
cleaning pads having a more abrasive side and a less abrasive side. More
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particularly, the present invention relates to two-sided wet wipes and
cleaning pads
that are disinfecting or sanitizing.
The invention is also a brassiere to be worn after breast surgery. The fabric
of the
brassiere includes antimicrobial fibers that control microbes on the skin of
the
woman's breast area both before and after surgical incisions are healed. It is
known
that combinations of containing polyoxyalkylene chains between two amino
groups, Hexamethylenediamine (1,6-hexanediamine) guanidinium derivatives,
particularly to combinations of oligo(2-(2-ethoxy)ethoxy ethyl guanidinium
chloride), modified polyhexamethylene guanidine (PHMG) as an antimicrobial
agent., poly(hexamethylendiamine guanidinium chloride), Polietheramine
derivatives (JEFFAMINE EDR-148), Polietheramine (Triethyleneglycol diamine
(TEGDA) enzymes, PGPR, amino acids, antioxidants like humic acids and some
natural products like phytotherapeutic plant extracts can be used to prevent
growth
of bacteria which cause breast area .
Nonwoven and woven materials are used to make a variety of products for use in
various industries. There remains a need, however, for such materials having
antimicrobial properties to eliminate microorganisms in various applications,
including applications requiring an antimicrobial barrier (e.g., wound
dressings,
face masks, etc). It is known that combinations of containing polyoxyalkylene
chains between two amino groups, Hexamethylenediamine (1,6-hexanediamine)
guanidinium derivatives, particularly to combinations of oligo(2-(2-
ethoxy)ethoxy
ethyl guanidinium chloride), modified polyhexamethylene guanidine (PHMG) as
an antimicrobial agent., poly(hexamethylendiamine guanidinium chloride),
Polietheramine derivatives (JEFFAMINE EDR-148), Polietheramine
(Triethyleneglycol diamine (TEGDA) enzymes, PGPR, amino acids, antioxidants
like humic acids and some natural products like phytotherapeutic plant
extracts can
be used to prevent growth of bacteria, fungua and virus in wound dressing,
facial
masks, surgical drapes and surgical clothing, to filter materials, panty,
handkerchief, pad, scouring padõ disposable sheets and similar applications
made
by nonwoven, woven and non woven ¨cotton materials.
42
CA 03121644 2021-05-31
WO 2020/112039
PCT/TR2018/050753
In accordance with the invention, a method for preventing, inhibiting or
eliminating
the growth, dissemination and/or accumulation of microorganisms on a
susceptible
surface (including but not limited to the formation of biofilms) comprises the
step
of contacting such surface with an antimicrobial agent, or composition thereof
of
the invention, with an amount sufficient to prevent, inhibit or eliminate such
growth, dissemination and/or accumulation, i.e., with an effective amount on
wound dressing, facial masks, surgical drapes and surgical clothing, to filter
materials, panty, handkerchief, pad, scouring padõ disposable sheets and
similar
applications.
As used herein "contacting" refers to any means for providing the compounds of
the invention to a surface to be protected from, microbial growth and/or
biofilm
formation. Contacting can include spraying, wetting, immersing, dipping,
painting,
bonding, coating, adhering or otherwise providing a surface with a compound or
composition in accordance with the invention. A "coating" refers to any
temporary,
semipermanent, or permanent layer, covering a surface. A coating can be a gas,
vapor, liquid, paste, semi solid or solid. In addition a coating can be
applied as a
liquid and solidify into a hard coating. Examples of coatings include
polishes,
surface cleaners, caulks, adhesives, finishes, paints, waxes, polymerizable
compositions (including phenolic resins, silicone polymers, chlorinated
rubbers,
coal tar and epoxy combinations, epoxy resins, polyamide resins vinyl resins,
elastomers, acrylate polymers, fluoropolymers, polyesters and polyurethane,
latex).
Silicone resins, silicone polymers (e.g. RTV polymers) and silicone heat cured
rubbers are suitable coatings for use in the invention and described in the
art.
Coatings can be ablative or dissolvable, so that the dissolution rate of the
matrix
controls the rate at which the compositions of the invention are delivered to
the
surface. Coatings can also be non-ablative, and rely on diffusion principals
to
deliver a composition of the invention to the wound dressing, facial masks,
surgical
drapes and surgical clothing, to filter materials, panty, handkerchief, pad,
scouring
padõ disposable sheets and similar applications surface.
43
