ANTAGONISTES RECEPTEURS D'INTEGRINE

INTEGRIN RECEPTOR ANTAGONISTS

Abrégé français

L'invention concerne des composés se liant à des récepteurs d'intégrine, leur fabrication, leur utilisation comme antagonistes récepteurs d'intégrine et pour le traitement de maladies, des préparations pharmaceutiques renfermant ces composés, ainsi que des préparations pharmaceutiques renfermant au moins un autre composé actif.

Abrégé anglais

The invention relates to new compounds which bind to integrin receptors, as
well as to their production, their use as integrin receptor antagonists and
for the treatment of diseases, pharmaceutical preparations containing said
compounds and pharmaceutical preparations containing at least one other active
compound.

Revendications

-357-
We claim:
1. A compound of the formula I
A-E-G-L I
where A, E, G and L have the following meanings:
L a structural element of the formula I L,
<IMG>
where
a is 0 or 1,
T is a COOH group or a radical which can be hydrolyzed to COOH,
R2 is hydrogen, NHSO2R21, NHCOR21 or NHCOOR22,
where
R21 is a branched or unbranched, optionally substituted C1-C6-alkyl, C3-C6-
cycloalkyl, C1-C4-alkyl-C3-C6-cycloalkyl radical, C5-C12-bicycloalkyl or
C6-C18-tricycloalkyl radical, an up to trisubstituted, with identical or
different radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6-
membered, saturated, unsaturated or aromatic heterocycle which may
contain up to three different or identical heteroatoms O, N, S, it being
possible for two radicals together to be a fused, saturated, unsaturated
or aromatic carbocycle or heterocycle which may contain up to three
different or identical heteroatoms O, N, S, and this ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated
or aromatic ring can be fused to this ring,

-358-
R22 is a branched or unbranched, optionally substituted C1-C6-alkyl radical
or an optionally substituted aryl or alkylaryl radical,
R3 is hydrogen or -(CH2)b-(X)c -R31,
where
b is 0, 1, 2 or 3,
c is 0 or 1,
X is -SO2-, -S-, -O-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-
,-CO-N(R31)-, -N(R31)-CO-, -SO2-NH-, -SO2-N(R31)- or -N(R31)-SO2-
R31 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary
substitution, an optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl
or C2-C6-alkenyl radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl
radical or a 3- to 6-membered, saturated or unsaturated heterocycle
which is substituted by up to three identical or different radicals and
which may contain up to three different or identical heteroatoms O, N,
S, C3-C8-cycloalkyl, aryl or hetaryl radical, it being possible for two
radicals together to be a fused, saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and the ring can optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
and~
R4 is hydrogen, or a branched or unbranched, optionally substituted C~-a-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
G a structural element of the formula I G,

-359-
<IMG>
where
d is 0, 1 or 2,
R5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary
substitution, an optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl
or C2-C6-alkenyl radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl
radical or a 3- to 6-membered, saturated or unsaturated heterocycle
which is substituted by up to three identical or different radicals and
which may contain up to three different or identical heteroatoms O, N,
S, C3-8-cycloalkyl, aryl or hetaryl radical, it being possible for two
radicals together to be a saturated, unsaturated or aromatic carbocycle
or heterocycle which may contain up to three different or identical
heteroatoms O, N, S, and the ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring
can be fused to this ring, or the side chain of a natural amino acid,
R6 is hydrogen or a branched or unbranched, optionally substituted C1-4-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
E a structural element of the formula I E
-(NH)g-(CH2)f-Q-(CH2)e-CO- I E
where
a is 0, 1 or 2,
f is 0 or 1,

-360-
g is 0 or 1,
Q is a doubly linked, optionally substituted hetaryl radical, it being
possible
for two substituents together to be a saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and this ring can optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
A one of the structural elements of the formulae I A1 to I A20,
<IMGS>

-361-
where
R10, R11 are, independently of one another, hydrogen, -(CH2)h-(Y)i-R101, or
the two
radicals together are a 3- to 8-membered, optionally substituted, saturated,
unsaturated or aromatic N-heterocycle which may additionally contain two
other, identical or different heteroatoms O, N or S,
where
h is 0, 1, 2 or 3,
i is 0 or 1,
Y is -SO2-, -S-, -O-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NH-CO-,
-CO-NH-, -CO-N(R101)-, -N(R101)-CO-, -SO2-NH-, -N(R101)-SO2- or
-SO2-N(R101)- and
R101 is a hydroxyl group, a branched or unbranched, optionally substituted
C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an amino
radical with primary or optionally secondary or tertiary substitution, an
optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted
by up to three identical or different radicals and which may contain up to
three different or identical heteroatoms O, N, S, C3-8-cycloalkyl, aryl or
hetaryl radical, it being possible for two radicals together to be a fused,
saturated, unsaturated or aromatic carbocycle or heterocycle which
may contain up to three different or identical heteroatoms O, N, S, and
the ring can optionally be substituted, or another, optionally substituted,
saturated, unsaturated or aromatic ring can be fused to this ring,
R12 is a branched or unbranched, optionally substituted C1-C4-alkyl,
alkylaryl,
C3-C6-cycloalkyl or C1-C4-alkyl-C3-C6-cycloalkyl radical or an optionally
substituted aryl radical,

-362-
R13 is hydrogen, -OH, -CN, -CONH2, a branched or unbranched, optionally
substituted C1-C4-alkyl, C1-C4-alkoxy or -O-CO-C1-C4-alkyl radical, or an
optionally substituted alkylaryl, -O-alkylaryl, -O-CO-aryl, -O-CO-alkylaryl or
-O-CO-allyl radical,
R14 is hydrogen, a branched or unbranched, optionally substituted C1-C4-alkyl,
-CO-O-C1-C4-alkyl, alkylaryl, -CO-O-alkylaryl, -CO-O-allyl, -CO-C,-C4-alkyl,
-CO-alkylaryl or -CO-allyl radical,
R15 is hydrogen, a branched or unbranched, optionally substituted C1-C4-alkyl
radical or an optionally substituted aryl or alkylaryl radical,
R16, R17 are, independently of one another, -NH2, halogen or a branched or
unbranched, optionally substituted C1-C4-alkyl or C1-C4-alkoxy radical or an
optionally substituted aryl radical,
Z1, Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or
N,
and the physiologically tolerated salts, prodrugs and the enantiomerically
pure or
diastereomerically pure and tautomeric forms.
2. A pharmaceutical preparation for oral or parenteral administration,
comprising at
least one compound as claimed in claim 1 besides conventional pharmaceutical
excipients.
3. The use of a compound as claimed in claim 1 for producing drugs for
treating
diseases.
4. The use as claimed in claim 3 of a compound as claimed in claim 1 as
integrin
receptor antagonist.
5. The use as claimed in claim 4 of a compound as claimed in claim 1 as
antagonist
of the .alpha.v.beta.3 integrin receptor.
6. The use of a compound as claimed in claim 1 for producing drugs for
treating
diseases in which an integrin receptor is involved.

-363-
7. The use as claimed in claim 6 of a compound as claimed in claim 1 for
treating
diseases in which the .alpha.v.beta.3 integrin receptor is involved.
8. The use as claimed in claim 7 of a compound as claimed in claim 1 for
treating
atherosclerosis, rheumatoid arthritis, restenosis after vessel injury,
angioplasty,
acute kidney failure, angiogenesis-associated microangiopathies, diabetic
angiopathies, blood platelet-mediated vascular occlusion, arterial thrombosis,
congestive heart failure, myocardial infarct, stroke, cancer, osteoporosis,
high
blood pressure, psoriasis or viral, parasitic or bacterial diseases,
inflammations,
wound healing, hyperparathyroidism, Paget's disease, malignant hypercalcemia
or
metastatic osteolytic lesions.
9. A pharmaceutical preparation comprising at least one compound as claimed in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
inhibitors of blood platelet adhesion, activation or aggregation,
anticoagulants which prevent thrombin activity or formation,
antagonists of blood platelet-activating compounds or
selectin antagonists.
10. The use of the pharmaceutical preparation as claimed in claim 9 for
producing a
drug for treating blood platelet-mediated vascular occlusion or thrombosis.
11. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
inhibitors of blood platelet activation or aggregation,
serine protease inhibitors,
fibrinogen-reducing compounds,
selectin antagonists,
antagonists of ICAM-1 or VCAM-1
inhibitors of leukocyte adhesion
inhibitors of vessel wall transmigration,
fibrinolysis-modulating compounds,
inhibitors of complement factors,
endothelin receptor antagonists,
tyrosine kinase inhibitors,

-364-
antioxidants or
interleukin 8 antagonists.
12. The use of the pharmaceutical preparation as claimed in claim 11 for
producing a
drug for treating myocardial infarct or stroke.
13. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
endothelia antagonists,
ACE inhibitors,
angiotensin receptor antagonists,
endopeptidase inhibitors,
beta blockers,
calcium channel blockers,
phosphodiesterase inhibitors or
caspase inhibitors.
14. The use of the pharmaceutical preparation as claimed in claim 13 for
producing a
drug for treating congestive heart failure.
15. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
thrombin inhibitors,
inhibitors of factor Xa,
inhibitors of the coagulation pathway which leads to thrombin formation,
inhibitors of blood platelet adhesion, activation or aggregation,
endothelia receptor antagonists,
nitric oxide synthase inhibitors,
CD44 antagonists,
selectin antagonists,
MCP-1 antagonists,
inhibitors of signal transduction in proliferating cells,
antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF, or
antioxidants.

-365-
16. The use of the pharmaceutical preparation as claimed in claim 15 for
producing a
drug for treating restenosis after vessel injury or stent implantation.
17. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF,
heparin or low molecular weight heparins or other GAGs,
inhibitors of MMPs,
selectin antagonists,
endothelia antagonists,
ACE inhibitors,
angiotensin receptor antagonists,
glycosylation inhibitors or
AGE formation inhibitors or antagonists of their receptors.
18. The use of the pharmaceutical preparation as claimed in claim 17 for
producing a
drug for treating diabetic angiopathies.
19. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
lipid-lowering compounds,
selectin antagonists,
antagonists of ICAM-1 or VCAM-1
heparin or low molecular weight heparin or other GAGs,
inhibitors of MMPs,
endothelia antagonists,
apolipoprotein A1 antagonists,
cholesterol antagonists,
HMG-CoA reductase inhibitors,
ACAT inhibitors,
ACE inhibitors,
angiotensin receptor antagonists,
tyrosine kinase inhibitors,

-366-
protein kinase C inhibitors,
calcium channel blockers,
LDL receptor function stimulants,
antioxidants or
free radical scavengers.
20. The use of the pharmaceutical preparation as claimed in claim 19 for
producing a
drug for treating atherosclerosis.
21. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
cytostatic or antineoplastic compounds,
compounds which inhibit proliferation or
heparin or low molecular weight heparins or other GAGs.
22. The use of the pharmaceutical preparation as claimed in claim 21 for
producing a
drug for treating cancer.
23. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
compounds for antiresorptive therapy,
compounds for hormone replacement therapy,
recombinant human growth hormone,
bisphosphonates,
compounds for calcitonin therapy,
calcitonin stimulants,
calcium channel blockers,
bone formation stimulants,
interleukin-6 antagonists or
Src tyrosine kinase inhibitors.
24. The use of the pharmaceutical preparation as claimed in claim 23 for
producing a
drug for treating osteoporosis.

-367-
25. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
TNF antagonists,
antagonists of VLA-4 or VCAM-1,
antagonists of LFA-1, Mac-1 or ICAMs,
complement inhibitors,
immunosuppressants,
interleukin-1, -5 or -8 antagonists or
dihydrofolate reductase inhibitors.
26. The use of the pharmaceutical preparation as claimed in claim 25 for
producing a
drug for treating rheumatoid arthritis.
27. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, with appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
collagenase,
PDGF antagonists or
MMPs.
28. The use of the pharmaceutical preparation as claimed in claim 27 for
producing a
drug for improving wound healing.

Description

DEMANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE I)E CETTE DEMANDE OU CE BREVETS
COMPRI~:ND PLUS D'UN TOME.
CECI EST ~.E TOME 1 DE 2
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
THIS IS VOLUME 1 OF 2
NOTE: For additional vohxmes please contact the Canadian Patent Oi~ice.

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
Integrin receptor antagonists
The invention relates to novel compounds which bind to integrin receptors,
their preparation
and use.
Integrins are cell surface glycoprotein receptors which mediate interactions
between cells of
the same type and different cells, and between cells and extracellular matrix
proteins. They
are involved in physiological processes such as, for example, embryogenesis,
hemostasis,
wound healing, immune response and formation) maintenance of the tissue
architecture.
Disturbances of the expression of cell adhesion molecule genes, and
disturbances of
receptor function may contribute to the pathogenesis of a large number of
disorders such as,
for example, tumors, thromboembolic events, cardiovascular disorders,
pulmonary diseases,
disorders of the CNS, of the kidney, of the gastrointestinal tract or
inflammations.
Integrins are heterodimers each consisting of an a and a (3 transmembrane
subunit which
are connected noncovalently. To date, 16 different a and 8 different (3
subunits and 22
different combinations have been identified.
Integrin a~(33, also called vitronectin receptor, mediates adhesion to a large
number of ligands
- plasma proteins, extracellular matrix proteins, cell surface proteins - most
of which contain
the aminoacid sequence RGD (Cell, 1986, 44, 517-518; Science 1987, 238, 491-
497), such
as, for example, vitronectin, fibrinogen, fibronectin, von Willebrand factor,
thrombospondin,
osteopontin, laminin, collagen, thrombin, tenascin, MMP-2, bone sialoprotein
II, various viral,
parasitic and bacterial proteins, natural integrin antagonists such as
disintegrins, neurotoxins
- mambin - and leech proteins - decorsin, ornatin - and same non-RGD ligands
such as, for
example, Cyr-61, PECAM (L. Piali, J. Cell Biol. 1995, 130, 451-460; Buckley,
J. Cell Science
1996, 109, 437-445, J. Biol. Chem. 1998, 273, 3090-3096).
Several integrin receptors show cross-reactivity with ligands which contain
the RGD motif.
Thus, integrin anb(33, also called platelet fibrinogen receptor, recognizes
fibronectin,
vitronectin, thrombospondin, von Willebrand factor and fibrinogen.
Integrin aV(33 is expressed inter alia on endothelial cells, blood platelets,
monocyteslmacrophages, smooth muscle cells, some B cells, fibroblasts,
osteoclasts and
various tumor cells such as, for example, melanomas, glioblastomas, carcinomas
of the
lung, breast, prostate and bladder, osteosarcomas or neuroblastomas.

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
_2_
Increased expression is observed under various pathological conditions, such
as, for
example, in the prothrombotic state, in cases of vessel injury, tumor growth
or metastasis or
reperfusion and on activated cells, in particular on endothelial cells, smooth
muscle cells or
macrophages.
Involvement of integrin a"~i3 has been detected inter alia in the following
pathological states:
cardiovascular disorders such as atherosclerosis, restenosis after vessel
injury, and
angioplasty (neointima formation, smooth muscle cell migration and
proliferation) (J. Vasc.
Surg. 1994, 19, 125-134; Circulation 1994, 90, 2203-2206),
acute kidney failure (Kidney Int. 1994, 46, 1050-1058; Proc. Natl. Acad. Sci.
1993, 90, 5700-
5704; Kidney Int. 1995, 48, 1375-1385),
angiogenesis-associated microangiopathies such as, for example, diabetic
retinopathy or
rheumatoid arthritis (Ann. Rev. Physiol 1987, 49, 453-464; Int. Ophthalmol.
1987, 11, 41-50;
Cell 1994, 79, 1157-1164; J. Biol. Chem. 1992, 267, 10931-10934),
arterial thrombosis,
stroke (phase II studies with ReoPro, Centocor Inc., 8'" annual European
Stroke Meeting),
cancers such as, for example, in tumor metastasis or tumor growth (tumor-
induced
angiogenesis) (Cell 1991, 64, 327-336; Nature 1989, 339, 58-61; Science 1995,
270, 1500
1502),
osteoporosis (bone resorption after proliferation, chemotaxis and adhesion of
osteoclasts to
bone matrix) (FASEB J. 1993, 7, 1475-1482; Exp. Cell Res. 1991, 195, 368-375,
Cell 1991,
64, 327-336),
high blood pressure, psoriasis, hyperparathyroidism, Paget's disease,
malignant
hypercalcemia, metastatic osteolytic lesions, inflammation, heart failure,
CHF, and for
antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion
and internalization).
Because of its key role, pharmaceutical preparations which contain low
molecular weight

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-3-
integrin a~,a3 antagonists are of great therapeutic and diagnostic use inter
alia for the said
indications.
Advantageous a"~i3 integrin receptor antagonists bind to the integrin a~(33
receptor with
increased affinity.
Particularly advantageous a"(33 integrin receptor antagonists additionally
have increased
selectivity for integrin av(33 and have less effect on integrin am(33 by a
factor of at least 10,
preferably by a factor of at least 100.
An integrin a"~i3 antagonist effect has been shown, and a beneficial in vivo
effect has been
demonstrated, for a large number of compounds such as anti-a"(33 monoclonal
antibodies,
peptides containing the RGD binding sequence, natural RGD-containing proteins
(for
example disintegrins) and low molecular weight compounds (FEBS Letts 1991,
291, 50-54;
J. Biol. Chem. 1990, 265, 12267-12271; J. Biol. Chem. 1994, 269, 20233-20238;
J. Cell Biol
1993, 51, 206-218; J. Biol. Chem. 1987, 262, 17703-17711; Bioorg. Med. Chem.
1998, 6,
1185-1208).
WO 9708145 describes meta-guanidine, urea, thiourea or azacyclic aminobenzoic
acid
derivatives and their use as av(33 integrin receptor antagonists.
It is an object of the present invention to provide novel integrin receptor
antagonists with
advantageous properties.
We have found that this object is achieved by compounds of the formula I
A-E-G-L
where A, E, G and L have the following meanings:
L a structural element of the formula I~
~a R2
~~T zL
Rj

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-4-
where
a is0or1,
T is a COOH group or a radical which can be hydrolyzed to COOH,
RZ is hydrogen, NHS02Rz', NHCORz' orNHCO0R22,
where
Rz' is a branched or unbranched, optionally substituted C~-Cs-alkyl, C3-C6-
cycloalkyl, C~-C4-alkyl-C3-C6-cycloalkyl radical, CS-C,2-bicycloalkyl or C6-
C~e-tricycloalkyl radical, an up to trisubstituted, with identical or
different
radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6-membered,
saturated,
unsaturated or aromatic heterocycle which may contain up to three different
or identical heteroatoms O, N, S, it being possible for two radicals together
to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle
which may contain up to three different or identical heteroatoms O, N, S,
and this ring can optionally be substituted, or another, optionally
substituted, saturated, unsaturated or aromatic ring can be fused to this
ring,
RZZ is a branched or unbranched, optionally substituted C~-Cg-alkyl radical or
an
optionally substituted aryl or alkylaryl radical,
R3 is hydrogen or -(CH2)b-(X)~-R3',
where
b is 0, 1, 2 or 3,
c is0or1,
X is -SOZ-, -S-, -O-, -CO-, -NH-SOZ-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-,
-CO-N(R3')-, -N(Rs,)-CO-, -SOZ-NH-, -SOZ-N(Rs,)- or-N(R3')-S02-,
R3' is hydrogen, a hydroxyl group, a branched or unbranched, optionally

CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
-5-
substituted C~_C~-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary substitution,
an optionally C~_C4-alkyl- or aryl-substituted CZ-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C~2-bicycloalkyl, C6-C~$-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted by up
to three identical or different radicals and which may contain up to three
different or identical heteroatoms O, N, S, C3-C8-cycloalkyl, aryl or hetaryl
radical, it being possible for two radicals together to be a fused, saturated,
unsaturated or aromatic carbocycle or heterocycle which may contain up to
three different or identical heteroatoms O, N, S, and the ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
and
R4 is hydrogen, or a branched or unbranched, optionally substituted C~-4-
alkyl,
C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
G a structural element of the formula I~
where
Rb
JN IG
)d
R
d is 0, 1 or 2,
R5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C,-Cs-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary substitution,
an optionally C~-C4-alkyl- or aryl-substituted CZ-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C~2-bicycloalkyl, C6-C~8-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted by up
to three identical or different radicals and which may contain up to three
different or identical heteroatoms O, N, S, C3-CS-cycloalkyl, aryl or hetaryl

CA 02371604 2001-10-24
WO OOI66618 PCTIEP00103469
-6
radical, it being possible for two radicals together to be a saturated,
unsaturated or aromatic carbocycle or heterocycle which may contain up to
three different or identical heteroatoms O, N, S, and the ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring, or the side chain of a natural amino
acid,
R6 is hydrogen or a branched or unbranched, optionally substituted C,-C4-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
E a structural element of the formula IE
-(NH)s (CHZ)~Q-(CH2)e-CO- I
where
a is 0, 1 or 2,
f is0or1,
g is0orl,
Q is a doubly linked, optionally substituted hetaryl radical, it being
possible for
finro substituents together to be a saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and this ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring can
be fused to this ring,
A one of the structural elements of the formulae IAi to IAZo

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
_7_
Rls Rls R16
R17 'N TA2 R17 N _ ~~~3
''' \~/
N N
W
Rl ~. ~ IAa 10 ~ IA5 la Q IA( 1 R ~N IA7
R ~N~
Rll Rll
~N IA9 Z= Z~~ N
CN' ' N~ I
R15 R15 Z2' Z1 A15
N IAI1 N IA12 IA13
N~.-- ~N
~ is Ris
R Rls
0
N IA~.a ~~C IA15 ~ IAis
H' C~N
p N
~ls H
w
ZAm N IAie N ~A19 I~2a
I
I I
H
where
R'°, R" are, independently of one another, hydrogen, -(CH2),,-(Y);-
R'°', or the two
radicals together are a 3- to 8-membered, optionally substituted, saturated,
unsaturated or aromatic N-heterocycle which may additionally contain two
other,
identical or different heteroatoms O, N or S,
where
h is 0, 1, 2 or 3,

CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
_g_
is0or1,
Y is -SOZ-, -S-, -O-, -CO-, -NH-S02-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-,
-CO-N(R~°~)-, -N(R'°')-CO-, -SOZ-NH-, -N(R'°')-SOZ- or -
SOZ-N(R'°')- and
R'°' is a hydroxyl group, a branched or unbranched, optionally
substituted C1-
C6-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an amino radical with
primary or optionally secondary or tertiary substitution, an optionally C~-C4-
alkyl- or aryl-substituted Cz-C6-alkynyl or CZ-Cs-alkenyl radical, a C5-C~2-
bicycloalkyl, C6-C18-tricycloalkyl radical or a 3- to 6-membered, saturated or
unsaturated heterocycle which is substituted by up to three identical or
different radicals and which may contain up to three different or identical
heteroatoms O, N, S, C3~-cycloalkyl, aryl or hetaryl radical, it being
possible
for two radicals together to be a fused, saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms 0, N, S, and the ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring can
be fused to this ring,
R'2 is a branched or unbranched, optionally substituted C1-C4-alkyl,
alkylaryl, C3-C6-
cycloalkyl or C~-C4-alkyl-C3-C6-cycloalkyl radical or an optionally
substituted aryl
radical,
R'3 is hydrogen, -OH, -CN, -CONH2, a branched or unbranched, optionally
substituted Ci-C4-alkyl, C~-C4-alkoxy or -OCO-C,-C4-alkyl radical, or an
optionally
substituted alkylaryl, -O-alkylaryl, -OCO-aryl, -OCO-alkylaryl or -OCO-ally!
radical,
R'4 is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl,
alkyl
aryl, -COZ-C~-C4-alkyl, -C02-alkylaryl, -COZ-ally!, -CO-C,-Cø-alkyl, -CO-
alkylaryl or
-CO-ally! radical,
R'S is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl
radical
or an optionally substituted aryl or alkylaryl radical.
R'6, R" are, independently of one another, -NH2, halogen or a branched or
unbranched, optionally substituted C1-C4-alkyl or C,-C4-alkoxy radical or an
optionally substituted aryl radical,

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-g_
Z', Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or N
and the physiologically tolerated salts, prodrugs and the enantiomerically
pure or
diastereomerically pure and tautomeric forms.
T in the structural element L means a COOH group or a radical which can be
hydrolyzed to
COOH. A radical which can be hydrolyzed to COOH means a radical which is
converted into
a COOH group after hydrolysis.
A group which may be mentioned as an example of a radical T which can be
hydrolyzed to
COOH is
O
_~C_R1
in which R' has the following meaning:
a) OM, where M can be a metal ration such as an alkali metal ration such as
lithium,
sodium, potassium, the equivalent of an alkaline earth metal ration such as
calcium,
magnesium and barium, or an environmentally compatible organic ammonium ion
such as tertiary C~-C4-alkylammonium or an ammonium ion, such as, for example,
ONa, OK or OLi,
b) a branched or unbranched, optionally halogen-substituted C~-Ce-alkoxy
radical such as,
for example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-
methylpropoxy, 2-
methylpropoxy, 1,1-dimethylethoxy, in particular methoxy, ethoxy, 1-
methylethoxy,
pentoxy, hexoxy, heptoxy, octoxy, difluoromethoxy, trifluoromethoxy,
chlorodifluoro-
methoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 1,1,2,2-
tetrafluoroethoxy,
2,2,2-trifluoroethoxy, 2-chloro-1,1,2-trifluoroethoxy or pentafluoroethoxy
c) a branched or unbranched, optionally halogen-substituted C~-C4-alkylthio
radical such
as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-
methylpropylthio, 2-
methylpropylthio or 1,1-dimethylethylthio radical
d) an optionally substituted -O-alkylaryl radical such as, for example, -O-
benzyl

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e) R' also a radical of the formula -(O)m-N(R'e)(R'9), in which m is 0 or 1,
and R'e and R'9,
which may be identical or different, have the following meaning:
hydrogen,
C,-C8-alkyl, such as, for example, methyl, ethyl, propyl, 1-methylethyl,
butyl, 1-methyl-
propyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-
methylbutyl, 1,2-
dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl,
1-
methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 1,1-
dimethylbutyl,
2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-
trimethylpropyl, 1-
ethylbutyl, 2-ethylbutyl, heptyl or octyl,
C3-C6-alkenyl such as, for example, 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-
2-
propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-
butenyl,
2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-
butenyl, 3-
methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-
propenyl,
2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-
pentenyl,
3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-
pentenyl, 1-
methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-
pentenyl, 1,1-
dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-
dimethyl-3
butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-
butenyl, 2,3
dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-
butenyl, 2-ethyl
2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-
propenyl
and 1-ethyl-2-methyl-2-propenyl, in particular 2-propenyl, 2-butenyl, 3-methyl-
2-butenyl
and 3-methyl-2-pentenyl,
C3-C6-alkynyl such as, for example, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-
2-
propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-
butynyl, 1-
methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-
hexynyl, 4-
hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-2-pentynyl, 1-methyl-3-
pentynyl, 1
methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-
pentynyl, 4
methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-
dimethyl-3
butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-
3-butynyl
and 1-ethyl-1-methyl-2-propynyl, preferably 2-propynyl, 2-butynyl, 1-methyl-2-
propynyl
and 1-methyl-2-butynyl, in particular 2-propynyl,
C3-C8-cycfoalkyl, such as, for example, cyclopropyl, cyclobutyl, cyclopenfyl,
cyclohexyl

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and cycloheptyl, cyclooctyl, it being possible for these alkyl, cycloalkyl,
alkenyl and
alkynyl groups each to be substituted,
phenyl, optionally substituted one or more times, for example one to three
times, by
halogen, nitro, cyano, C~-C4-alkyl, C1-C4-haloalkyl, C~-C4-alkoxy, C~-C4-
haloalkoxy or
C~-C4-alkylthio, such as, for example, 2-fluorophenyl, 3-chlorophenyl, 4-
bromophenyl,
2-methylphenyl, 3-nitrophenyl, 4-cyanophenyl, 2-trifluoromethylphenyl, 3-
methoxy-
phenyl, 4-trifluoroethoxyphenyl, 2-methylthiophenyl, 2,4-dichlorophenyl, 2-
methoxy-3-
methylphenyl, 2,4-dimethoxyphenyl, 2-vitro-5-cyanophenyl, 2,6-difluorophenyl
or R'$ and R'9 together form a C4-C~-alkylene chain which is closed to a ring,
is
optionally substituted, for example by C~-C4-alkyl and may contain a
heteroatom
selected from the group of oxygen, sulfur or nitrogen, such as, for example, -
(CHZ)a-,
-(CHz)s-~ -(CH2)s-, -(CHz)r~ -(CHZ)2-O-(CHz)2-, -CH2-S-(CH2)3-. -(CHz)z-O-
(CHZ)3-~ -NH-
(CH2)3-, -CHz-NH-(CHZ)2-, -CH2-CH=CH-CH2-, -CH=CH-(CH2)3-, -CO-(CHZ)2-CO- or
-CO-(CHz)3-CO-.
Preferred T radicals are -COOH, -CO-O-C~-Cs-alkyl or -CO-O-benryl.
A branched or unbranched C~-Cs-alkyl radical for R2' in the structural element
L means, for
example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-
methylpropyl, 1,1-
dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2-dimethylpropyl, 1,1-
dimethylpropyl,
2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl,
1,3-dimethylbutyl,
2,3-dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl,
1,1,2-
trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-
2-methylpropyl,
preferably methyl, ethyl, propyl, butyl or i-butyl.
A branched or unbranched C3-Cs-cycloalkyl radical for RZ' in the structural
element L means,
for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
A branched or unbranched C~-C4-alkyl-C3-Cs-cycloalkyl radical for R2' in
structural element L
means an abovementioned C3-Cs-cycloalkyl radical which is a substituent on a
C~-C4-alkyl
radical.
The C~-Cs-alkyl radicals, C3-Cs-cycloalkyl radicals or C~-C4-alkyl-C3-Cs-
cycloalkyl radical may
be substituted by up to 5 identical or different radicals selected from the
group of halogen,
aryl or hetaryl.

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A C5-C,Z-bicycloalkyl radical for Rz' means, for example, indanyl, norbornyl
or camphyl, and
a C6-C,$-tricycloalkyl radical means, for example, adamantyl.
An up to trisubstituted, with identical or different radicals, aryl,
alkylaryl, alkylhetaryl radical or
3- to 6-membered, saturated, unsaturated or aromatic heterocycle which may
contain up to
three different or identical heteroatoms O, N, S, it being possible for two
radicals together to
be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which
may contain
up to three different or identical heteroatoms 0, N, S, and for the ring to
optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring to be
fused to this ring for R2' in structural element L means, for example,
aryl radicals such as, for example, phenyl, 1-naphthyl or 2-naphthyl,
alkylaryl radicals such as, for example, benzyl or phenethyl,
alkylhetaryl radicals such as, for example, -CHZ-2-pyridyl, -CHz-3-pyridyl, -
CH2-4-pyridyl,
-CH2-2-thienyl, -CHr3-thienyl, -CHZ-2-thiazolyl, -CH2-4-thiazolyl, CH2-5-
thiazolyl, -CHZ-CHZ-2-
pyridyl, -CH2-CH2-3-pyridyl, -CH2-CHZ-4-pyridyl, -CHz-CHZ-2-thienyl, -CH2-CH2-
3-thienyl,
-CHZ-CHZ-2-thiazolyl, -CHz-CHZ-4.-thiazolyl, or -CH2-CH2-5-thiazolyl,
preferably -CHZ-2-
pyridyl, -CH2-2-thienyl, or-CHz-2-thiazolyl or
hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-
furyl, 3-furyl, 2-pyrrolyl,
3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazofyl, 2-
oxazolyl, 4-oxazolyl, 5-
oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-
pyrazolyl, 5-
pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-
imidazolyl, 5-imidazolyl,
3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-
pyridyl, 3-pyridyl, 4-
pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-
thiazolyl,
it being possible for the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals to be substituted by up to three identical or different radicals, for
example selected
from the following group:
-N02, -NHZ, -OH, -CN, -COOH, -COO-C,-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C,-C4-alkyl, C3-C6-cycloalkyl, C,-C4-alkoxy, C,-C4-
alkylthio, -O-CH2-
COO-C,-C4-alkyl, -NH-CO-C,-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOz-C,-C4-alkyl, -
SOz-NH-
C,-C4-alkyl, -N(C,-C4-alkyl)2, -NH-C,-C4-alkyl, or -SOZ-C,-C4-alkyl radical,
an optionally

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substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S02-phenyl, -S02-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benryl, -NH-SOZ-benryl, -S02-NH-benryl, an optionally
substituted radical -
S02-NT'Tz or -CO-NT'Tz where the two radicals T' and Tz may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms 0, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals for RZ' are C~-C4-alkyl, C3-C6-cycloalkyl, -COOH, -COOMe, -CF3, -CN,
C~-C4-alkoxy,
-SCH3, -O-CHz-COOH, phenyl, -SOZCH3, -NO2, -OH, -NHz, -N-pyrrolidinyl, -N-
piperidinyl, -N-
morpholinyl, -N-piperazinyl, -NH-C~-C4-alkyl, -N(C~-C4-alkyl)z, F, CI, Br or
I.
Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals for RZ' in which two radicals together are a fused, saturated,
unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or identical
heteroatoms 0,
N, S, and the ring can optionally be substituted or another optionally
substituted ring can be
fused to this ring, are the following doubly linked structural elements:
.>; O . /
>:
. O ,:'~o ~ '
H
.~~~S ~-N
,'~...~NS ~/ ~/ '/
A branched or unbranched C~-C~-alkyl radical for R22 in structural element L
means, for
example, the C~-C6-alkyl radicals mentioned above for Rz', preferably 1,1-
dimethylethyl.
Examples of aryl radicals for R~ in structural element L are phenyl, 1-
naphthyl or 2-naphthyl,
preferably phenyl; alkylaryl radicals for R22 in structural element L are
preferably benzyl or
phenethyl.
Suitable substituents on the C~-C6-alkyl radical, aryl radicals or alkylaryl
radicals for R2z in
structural element L are the substituents mentioned above for the aryl
radicals, the alkylaryl
radicals, alkylhetaryl radicals and hetaryl radicals of RZ'.

CA 02371604 2001-10-24
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In the radical R3 in structural element L, the index b can be 0, 1, 2 or 3,
preferably 0, 1 or 2,
and the index c can be 0 or 1. The radical X is a doubly linked radical
selected from the
group of -S02-, -S-, -O-, -CO-, -NH-S02-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-, -
CO-N(R3')-,
-N(R3')-CO-, -SOZ-NH-, -SOZ-N(R3')- or -N(R3')-SOZ-. In the case of radicals
which are
disubstituted by R3', the two R3' radicals can be identical or different.
A branched or unbranched C~-C6-alkyl radical for R3' in structural element L
means, for
example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-
methylpropyl, 1,1-di-
methylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2~limethylpropyl, 1,1-
dimethylpropyl, 2,2-
dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl, 1,3-
dimethylbutyl, 2,3-
dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-
trimethylpropyl,
1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-2-methylpropyl,
preferably methyl,
ethyl, propyl, butyl, iso-propyl, sec-butyl and tert-butyl.
A branched or unbranched C~-C4-alkoxy radical for R3' in structural element L
means, for
example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-
methylpropoxy or 1,1-dimethylethoxy, in particular methoxy, ethoxy or 1-
methylethoxy.
Examples of -O-alkylaryl or -O-aryl radicals are -O-phenyl, -O-1-naphthyl, -O-
2-naphthyl or
-O-benzyl.
The C,-C6-alkyl, C,-C4-alkoxy radicals of R3' in structural element L can be
substituted by up
to five identical or different radicals selected from the group of halogen,
aryl or hetaryl.
Substituted -O-alkylaryl or -O-aryl radicals mean, for example, the
abovementioned -O-alkyl-
aryl or -O-aryl radicals, it being possible for the aryl moiety to be
substituted by up to three
identical or different radicals selected from the following group:
-NO2, -NHz, -OH, -CN, -COOH, -C00-C~-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C,-C4-alkyl, C3-C6-cycloalkyl, C~-C4-alkoxy, C,-C4-
alkylthio, -0-CHz-
COO-C~-C4-alkyl, -NH-CO-C~-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOz-C~-C4-alkyl, -
SOZ-NH-
C,-C4-alkyl, -N(Ci-C4-alkyl)2, -NH-C~-C4-alkyl, or -SOZ-C~-C4-alkyl radical,
an optionally
substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-phenyl, -SOZ-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -SOz-NH-benzyl, an optionally
substituted radical
-SOz-NT'T2 or -CO-NT'TZ where the two radicals T' and T2 may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or

CA 02371604 2001-10-24
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heterocycle which may contain up to three different or identical heteroatoms
0, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
An amino radical with primary or optionally secondary or tertiary substitution
for R3' in
structural element L means a primary amino radical -NH2, a secondary amino
radical
-NH(R3") or a tertiary amino radical -N(R3")(Ral2), where
R3" and R3'2 can be, independently of one another, C~-C4-alkyl or C3-C6-
cycloalkyl as
mentioned above, optionally substituted aryl, preferably phenyl, alkylaryl,
preferably benzyl, -
CO-C~-C4-alkyl, preferably -CO-CH3 or -CO-aryl, preferably -CO-phenyl.
In the case where c = 1 and X = CO, the corresponding amide residues result.
Cyclic tertiary amide residues or amino radicals result in the case where R3'
is one of the
heterocyclic systems described below, which is linked via the ring nitrogen to
X = CO or
directly. Examples of preferred amide residues -X-R3' are
0 0 _
N N ~ VO
A C2-Cs-alkynyl or C2-C6-alkenyl radical which is optionally substituted by C,-
C4-alkyl or aryl
for R3' in the structural element L means, for example, CZ-Cs-alkynyl radicals
such as, for
example, ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-
pentynyl, 3-
pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-methyl-2-
butynyl, 1,1-
dimethyl-2-propynyl, 1~thyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-
hexynyl, 1-methyl-
2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-
methyl-4-
pentynyl, 3-methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl,
1,1-dimethyl-3-
butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-
ethyl-3-butynyl, 2-
ethyl-3-butynyl or 1-ethyl-1-methyl-2-propynyl, preferably 2-propynyl or
ethynyl
or C2-Cs-alkenyl radical such as, for example, vinyl, 2-propenyl, 2-butenyl, 3-
butenyl, 1-
methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-
methyl-2-
butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-Methyl-
3-butenyl, 3-
methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-
propenyl, 2-
hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-
pentenyl, 3-

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methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-
pentenyl, 1-methyl-
4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-
dimethyl-2-
butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-
butenyl, 1,3-dimethyl-
2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-2-
butenyl, 2,3-
dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-
ethyl-3-butenyl,
1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl or 1-ethyl-2-methyl-2-
propenyl, in
particular 2-propenyl or vinyl
which can be substituted by optionally substituted Ci-C4-alkyl radicals, or
aryl radicals as
mentioned above, preferably phenyl, such as, preferably, phenylethynyl or
phenylethenyl.
A C~-C~2-bicycloalkyl radical for R3' means, for example, indanyl, norbornyl
or camphyl, and
a C6-C,B-tricycloalkyl radical means, for example, adamantyl.
A 3-to 6-membered, saturated or unsaturated heterocycle which is substituted
by up to three
identical or different radicals and which may contain up to three different or
identical
heteroatoms O, N, S, C3-C8-cycloalkyl, aryl or hetaryl radical, it being
possible for two
radicals together to be a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
for the ring to
optionally be substituted, or another, optionally substituted, saturated,
unsaturated or
aromatic ring to be fused to this ring, for R3' in structural element L means,
for example
3- to 6-membered, saturated or unsaturated heterocycles which may contain up
to three
different or identical heteroatoms O, N, S, such as N-pyrrolidinyl, N-
piperidinyl, N-
hexahydroazepinyl, N-morpholinyl or N-piperazinyl, it being possible for free
amine protons in
heterocycles with free amine protons, such as, for example, N-piperazinyl, to
be replaced by
conventional amine protective groups such as, for example, methyl, benzyl, Boc
(tert-
butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -S02-C~-C4-alkyl, -SOZ-phenyl
or -S02-benzyl,
C3-C8-cycloalkyl radicals as described above for Rz',
aryl radicals such as, for example, phenyl, 1-naphthyl or 2-naphthyl or
hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-
furyl, 3-furyl, 2-pyrrolyl,
3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-
oxazolyl, 4-oxazolyl, 5-
oxazofyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-
pyrazolyl, 5-
pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-
imidazolyl, 5-imidazolyl,

CA 02371604 2001-10-24
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-17-
3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-
pyridyl, 3-pyridyl, 4-
pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-
thiazolyl,
it being possible for the heterocyclic, C3-C8-cycloalkyl, aryl and hetaryl
radicals optionally to
be substituted by up to three identical or different radicals, for example
selected from the
following group:
-NOz, -NH2, -OH, -CN, -COOH, -COO-C~-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C~-C4-alkyl, C3-C6-cycloalkyl, G~-C4-alkoxy, C~-C4-
alkylthio, -O-CHZ-
COO-C~-C4-alkyl, -NH-CO-Ci-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-S02-C,-C4-alkyl, -
SOZ-NH-
C~-C4-alkyl, -N(C~-C4-alkyl)2, -NH-C~-C4-alkyl, or -SOZ-C~-C4-alkyl radical,
an optionally
substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOrphenyl, -SOZ-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -S02-NH-benzyl, an optionally
substituted radical
-SOz-NT'Tz or -CO-NT'TZ where the two radicals T' and T2 may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
Preferred substituents of the heterocyclic, C3-C$-cycloalkyl, aryl and hetaryl
radicals for R3'
are C~-C4-alkyl, -COOH, -COOMe, -CF3, -CN, Ci-C4-alkoxy, -SCH3, -O-CH2-COOH, -
phenyl,
-SOzCH3, -N02, -OH, -NHz, -N-pyrrolidinyl-, -N-piperidinyl, -N-morpholinyl, -N-
piperazinyl,
-NH-C~-C4-alkyl, -N(C~-C4-alkyl)Z, F, CI, Br or I.
Preferred substituents of the heterocyclic, C3-C8-cycloalkyl, aryl and hetaryl
radicals for R3' in
which two radicals together are a fused, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, and the
ring can optionally be substituted, or another, optionally substituted ring
can be fused to this
ring, are the following, doubly linked structural elements:
,
. r
~ , ,
° %'o ; ~.
H
~S .YN
. S ,r ;~ ;..
.~~'" N

CA 02371604 2001-10-24
WO 00!66618 PCTJEPOOJ03469
-18
Examples of the resulting condensed ring systems for R3' are, for example, the
corresponding dioxolanyls, benzopyrrolyls, benzofuryls, benzothienyls or
fluorenyls,
A branched or unbranched, optionally substituted C~-C4-alkyl radical for R4 in
structural
element L means, for example, methyl, ethyl, propyl, i-propyl, butyl, t-butyl
or i-butyl,
preferably methyl.
A branched or unbranched, optionally substituted C3-C6-cycloalkyl radical for
R4 in structural
element L means the radicals mentioned above for Rz', which are optionally
substituted by
up to 5 radicals such as halogen or aryl, preferably cyclohexyl, cyclopentyl
or cyclopropyl.
C3-C~-alkenyl or C3-C6-alkynyl radicals for R4 in structural element L are the
radicals
mentioned above for R'8 or R'9, preferably ally! or propargyl.
Particularly preferred radicals for R4 are hydrogen, methyl, cyclopropyl,
ally! or propargyl, and
hydrogen is very particularly preferred.
Preferred structural elements L have a = 1, so that a (3-amino acid represents
the preferred
basic structure of the structural element L. In particularly preferred
structural elements L,
either the radical R2 = hydrogen and the radical R3 may vary widely as
described above, or
the radical R3 = hydrogen and the radical RZ may vary widely as described
above. Very
particularly preferred structural elements L have R2 = H and R3 may vary
widely as described
above, or R3 = H and RZ = -NHZ, -NH-SOZ-phenyl or -NH-SOZ-benzyl, where Z is
the
benzyloxycarbonyl protective group.
In structural element G of the formula I~, RS means hydrogen and,
independently of R3' in
structural element L, the same radicals as described above for R3' or another
side chain of a
natural amino acid. Preferred R5 radicals are hydrogen, methyl, ethynyl or
methyl-substituted
ethynyl, and hydrogen is particularly preferred.
Rs means, independently of R4, the same radicals as described above for R4.
Preferred Rs
radicals are hydrogen, methyl, ally!, propargyl or cyclopropyl, and hydrogen
is particularly
preferred.
In structural element E of the formula IE, Q means a doubly linked hetaryl
radical which is
optionally substituted by up to three other radicals, it being possible where
appropriate for two

CA 02371604 2001-10-24
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-19
radicals together to be a saturated, unsaturated or aromatic carbocycle or
heterocycle which
may contain up to three different or identical heteroatoms O, N, S, and the
ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can
be fused to this ring.
A hetaryl radical preferably means a 5- or 6-membered aromatic heterocyclic
system which
may contain up to three different or identical heteroatoms O, N, S, it being
possible for the
free amine protons in heterocycles with free amine protons, such as, for
example, imidazolyl,
triazolyl, pyrazolyl or pyrrolyl, to be replaced by conventional amine
protective groups such
as, for example, methyl, benryl, Boc (tent-butoxycarbonyl), Z
(benzyloxycarbonyl), tosyl, -
S02-C~-Ca-alkyl, -SOz-phenyl or -S02-benzyl.
Preferred hetaryl radicals Q which may be listed are the following structures
where the points
of linkage are indicated by a bond line:
N.
S
N-N ~ ~
N 11 ~~ %r '1
S ~N ~O. ~'~ /C,N,.
H H
~~- ~~~
N N N S
Particularly preferred hetaryl radicals Q which may be listed are the
following structures
where the fixed positions of the points of linkage are indicated by a bond
line, and the
structures can be incorporated in both orientations:

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00l03469
-20
I ! /
0 N~ 0
H
N_~ ~N N I~ l~ N N
O ~S~ ~S, ~Q
H
'W. ~ N ~ N
( i ( i ~ ~ ~ l1~ f'
N N N N
H H
Very particularly preferred hetaryl radicals Q which may be listed are the
following structures
where the fixed positions of the points of linkage are indicated by a bond
line, and the
structures can be incorporated in both orientations:
S S O O H N
~,~~
~ 'E'S'N x
As mentioned above, the free amine protons of imidazolyl, pyrazolyl, triazolyl
or pyrrolyl in
these preferred and particularly preferred structures can also be replaced by
conventional
amine protective groups such as, for example, methyl, benzyl, Boc (tert-
butoxycarbonyl), Z
(benzyloxycarbonyl), tosyl, -S02-C,-Ca-alkyl, -S02-phenyl or -SOZ-benzyl,
Preferred substitutents of the hetaryl radicals are, independently of one
another, one or two
radicals selected from the group of -CN, halogen, preferably CI or F, C~-C4-
alkyl, preferably
methyl, C~-C4-haloalkyl, preferably trifluoromethyl, C,-Ca-alkoxy, preferably
methoxy, -NH-C,-
C4-alkyl or aryl, preferably phenyl.
The structural element A is one of the structural elements of the formula
IA'to IA2o

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-21
Rls Rie Ris
R17 / IA1 Rl7 ~ n2 R17 " \ IA3
N N
0 Ri '
S
R1 ~, ~ IA4 R'- \N I, ZA5 R1 ~ p
Rii
~N IAs ~N IA9 Z/~a N IAlo
rt-~ N
Rls Ris ZZ\Zi Nls
R
N~ /All ( ~~A12 ~A13
N
N N
Ri s Ri 5 N
Ris
O
N xAl4 H3C N IA15 ~ ~ zAl6
O' _N
Rls H
N jAl7 N IA18 _N Inl9 In20
O~N
x
where the structural elements of the formula IA', IA2, IA3, IA~, IAS, IAe,
IA'°, or ~,q'3 are preferred,
and the structural element of the formula IA4
0
R1 1
4
A
R11
is particularly preferred, for the structural element A.

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-22
The radicals R'° and R" are, independently of one another and
independently of R3, the
radicals described above for R3 in structural element L, preferably C~-C4-
alkyl, C3-C8-cyclo-
alkyl, C,-Ca-alkyl-C3-Ce-cycloalkyl, aryl, alkylaryl, hetaryl or alkylhetaryl,
it being possible for
the aryl, alkylaryl, hetaryl and alkylhetaryl radicals to carry up to three
identical or different
radicals of the group F, CI, Br or I, C~-C4-alkyl, C3-C6-cycloalkyl, -COOH, -
COOMe, -CF3,
-CN, Ci-C4-alkoxy, -SCH3, -O-CHZ-COOH, phenyl, -S02CH3, -N02, -OH, -NH2, -N-
pyrrolidinyl, -N-piperidinyl, -N-morpholinyl, -N-piperazinyl, -NH-C~-C4-alkyl,
-N(C~-C4-alkyl)z,
-NH-CO-C~-C4-alkyl, -CO-NH-C,-C4-alkyl, -NH-SOZ-C~-C4-alkyl, -SOZ-NH-C~-C4-
alkyl, or
-S02-C~-C4-alkyl, optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-
phenyl,
-SOz-NH-phenyl, -NH-CO-benzyl, -CO-NH-benzyl, -NH-SO2-benzyl, -SOZ-NH-benzyl,
optionally substituted -SOz-NT'T2 or -CO-NT'T2, where the two radicals T' and
T~ may form
a cyclic amine,
or the two radicals R'° and R" together a 3- to 8-membered, optionally
substituted,
saturated, unsaturated or aromatic N-heterocyclic system which may
additionally contain two
other identical or different heteroatoms O, N, or S, such as, for example,
pyrrolidinyl,
piperidinyl, hexahydroazepinyl, piperazinyl or morpholinyl.
R'2 is a branched or unbranched, optionally substituted C~-C4-alkyl,
alkylaryl, C3-C6-cycloalkyl
or C~-C4-alkyl-C3-C6-cycloalkyl radical or an optionally substituted aryl
radical as described
above for Rz'.
A branched or unbranched, optionally substituted C~-C4-alkoxy or -O-alkylaryl
radical for R'3
means the corresponding radicals as described above for R3', preferably
methoxy or
benzyloxy. The radicals -OCO-C,-C4-alkyl-, -OCO-aryl-, -OCO-alkylaryl- or -OCO-
allyl- are
comprised of the group -OCO- and the C~-C4-alkyl, aryl or alkylaryl radicals
described above
under R3', or the allyl radical.
Preferred R'3 radicals are hydrogen, -OH, -O-benzyl, -OCO-phenyl, -OCO-benzyl,
-OCO-
allyl, -CN or-CO-NH2.
Analogously, the radicals -C02-C~~-alkyl-, -COz-alkylaryl-, -COz-allyl-, -CO-
C,-C4-alkyl-, -CO
alkylaryl- or -CO-allyl for the radical R'4 are composed of the group -C02- or
-CO- and the
C~-C4-alkyl, aryl radical described above under R3' or the allyl radical.
Preferred radicals for
R'4 are hydrogen, methyl, benzyl, -COO-benzyl, -COO-allyl, -CO-benzyl or -CO-
allyl.
R'S is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl
radical or an

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-23
optionally substituted aryl or alkylaryl radical as described above for R~' or
R4. Preferred R'S
radicals are hydrogen, methyl, benzyl or phenyl.
R's, R" are, independently of one another, -NH2, halogen, such as CI, Br, I or
F or a
branched or unbranched, optionally substituted C~-C4-alkyl or C,-C4-alkoxy or
optionally
substituted aryl radical as described above for R3', preferably NH2, CI, F,
methyl, methoxy or
phenyl.
Z', Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or
N, it being
preferred that Z' and Z2 or ZZ and Z3 or Z3 and Z4 are not simultaneously N.
Unless specified in detail, substituted aryl, alkylaryl, hetaryl or
alkylhetaryl radicals in the
description mean aryl, alkylaryl, hetaryl or alkylhetaryl radicals which may
be substituted by
up to three identical or different radicals selected from the following group:
-NO2, -NHz, -OH, -CN, -COOH, -O-CH2-COOH, -COO-C1-C4-alkyl, halogen, a
branched or
unbranched, optionally substituted C~-C4-alkyl, C3-Cs-cycloalkyl, C~-C4-
alkoxy, C~-C4-alkyl-
thio, -O-CH2-COO-C~-C4-alkyl, -NH-CO-Ci-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOZ-
C,-C4-
alkyl, -S02-NH-C~-Ca-alkyl, -N(Ci-C4-alkyl)z, -NH-C~-C4-alkyl, or -SOz-Ci-C4-
alkyl radical, an
optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-phenyl, -S02-NH-
phenyl,
-NH-CO-benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -S02-NH-benzyl, an optionally
substituted
radical -S02-NT'T2 or -CO-NT'TZ where the two radicals T' and T2 may form a
cyclic amine,
or a 3- to 6-membered, optionally substituted, saturated, unsaturated or
aromatic carbocycle
or heterocycle which may contain up to three different or identical
heteroatoms O, N, S, or
two radicals together are a fused, saturated, unsaturated or aromatic
carbocycle or hetero-
cycle which may contain up to three different or identical heteroatoms O, N,
S, and the ring
can optionally be substituted or another, optionally substituted ring can be
fused to this ring.
The compounds of the formula I and also the intermediates for their
preparation may have
one or more asymmetric substituted carbon atoms. The compounds may be in the
form of
pure enantiomers or pure diastereomers or mixture thereof. It is preferred to
use an
enantiomerically pure compound as active ingredient.
The compounds of the formula I may also be in the form of physiologically
tolerated salts.
The compounds of the formula I may also be in a prodrug form in which the
compounds of
the formula I are liberated under physiological conditions. Reference may be
made herd for

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-24
example to the group T in structural element L, which in some cases contains
groups which
can be hydrolyzed under physiological conditions to the free carboxyl group.
Derivatized
structural elements A which liberate the structural element A under
physiological conditions
are also suitable.
In a preferred embodiment of the compounds of the formula I, the indices a, e,
f and g and
the heterocycle Q are chosen so that the distance between the group T and the
structural
element A is from 10 to 14 atomic linkages, preferably 11 to 13 atomic
linkages, along the
shortest possible route along the molecule backbone.
Further preferred compounds of the formula I have the preferred structural
elements A of the
formula IA', IqZ, Ip3, Iq°, IgS, IqB, IA'° or IA'3 whsle the
structural elements E, G and L may vary
widely as described above.
Further preferred compounds of the formula I have the particularly preferred
structural
element A of the formula Iq4, while the structural elements E, G and L may
vary widely as
described above.
Particularly preferred compounds of the formula I have the preferred
structural elements A of
the formula Iq', Iq~, Iq3, Iq°, IqS, IAe, IA'° or Iq'3 and the
preferred region of the structural
element L, while the structural elements E and G may vary widely as described
above.
Further particularly preferred compounds of the formula I have the
particularly preferred
structural element A of the formula Iq4 and the preferred region of the
structural element L,
while the structural elements E and G may vary widely as described above.
Further particularly preferred compounds of the formula I have the preferred
structural
element A of the formula Iq4 and the preferred region of the structural
element E, while the
structural elements L and G may vary widely as described above.
Very particularly preferred compounds of the formula I have the preferred
structural element
A of the formula Iq4, the preferred region of the structural element E and the
preferred region
of the structural element L, while the structural element G may vary widely as
described
above.
Further very particularly preferred compounds of the formula I have the
preferred region of
the structural element A, the preferred region of the structural element E and
the preferred,

CA 02371604 2001-10-24
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-25
region of the structural element G, while the structural element L may vary
widely as
described above.
Extremely preferred compounds of the formula I have the preferred structural
element A of
the formula IA" and the preferred regions of the structural elements E, G and
L.
Very preferred compounds of the formula I are listed in the following table,
where "compound
number" stands for the number of an individualized compound A-E-G-L of the
formula I, the
compound number and the respective compound are separated by a colon, and the
meaning
of the abbreviations of the structural elements A-E-G-L is explained after the
table.

CA 02371604 2001-10-24
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-26
Compound number: A-E-G-L
1: bhs-25thiaz-nmgly-betaoxaz
2: phhs-24thiaz-bala-betabph
3: bhs-25thiaz-ser-betapy
4: thazep-24thiaz~ly-beta13bendi
5: bim-24thiaz-gly-betatrif
6: bhs-24thioph-gly-betapyee
7: bhs-me25thioph-ala-beta34meoph
8: tolhs-24thioph-gly-betafbph
9: tolhs-24thioph-gly-betameph
10: bim-me24thiaz-bala-betaph
11: bhs-me25thioph-leu-beta34meoph
12: ibhs-24thioph-gly-betathiome
13: bhs-nme35pyr-gly-betabthioph
14: tolhs-nme35pyr-gly-betafu2
15: bhs-ithiadiaz-gly-betahmofu
16: phhs-nme35pyr-bala-betacph
17: impy-24thiaz-bala-betafu3
18: tolhs-25methiaz-bala-psdaptb
19: sabhs-25thiaz-gly-psdap
20. bhs-24thioph-gly-betadcphtb
21: 2py-nme35pyr-leu-psdap
22: bhs-nme35pyr-gly-aspbzla
23: phhs-me24thiaz-gly-zdap
24: bhs-25thiaz-bala-betameph
25: phhs-me24thiaz-ala-beta34meoph
26: tolhs-25methiaz-gly-beta34meoph
27: ibhs-ithiadiaz-gly-betafbph
28: tolhs-ithiadiaz-bala-asppha
29: phhs-ithiadiaz-baia-betaamibe
30: tolhs-24thioph-bala-betabmph
31: phhs-25methiaz-bala-betaol
32: bhs-25oxaz-bala-betamethi
33: ibhs-24thiaz-bala-betahni
34: gua-24thiaz-gly-betaftrif
35: bhs-24thiaz-gly-betafphe

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
_27_
36: tolhs-oxadiaz-gly-psdaptb
37: phhs-25methiaz-bala-betatbuph
38: bhs-24thiaz-nmgly-betathio3
39: phhs-24thioph-gly-betatos
40: 2py-thiadiaz-leu-psdap
41: dhim-35py-gly-betameph
42: bhs-ithiadiaz-gly-aspaba
43: phhs-oxadiaz-gly-beta4bph
44: bhs-25thiaz-gly-csdap
45: ibhs-25thiaz-gly-betahph
46: phhs-25methiaz~ly-betahdbph
47: bim-me25thioph-gly-betaph
48: ibhs-ithiadiaz-bala-beta3quin
49: tolhs-oxadiaz-gly-betadhbfu
50: bhs-oxadiaz-leu-psdap
51: impy-24thioph-bala-betainyl
52: bhs-25methiaz-ala-beta23meoph
53: phhs-24thiaz-gly-betabnaphth
54: impy-42nmeim-bala-betathiome
55: bim-35thioph-ala-betadcph
56: 2py-me24thiaz-gly-betapy
57: phhs-24thioph-bala-betaimid
58: phhs-24thioph-gly-betadhbfu
59: phhs-nme35pyr-bala-betaibph
60: bhs-25thiaz-ser-betameph
61: tolhs-25thiaz-bala-zdap
62: bim-25thiaz-gly-betadcph
63: 2pmhs-42nmeim-gly-betaamibe
64: 2py-24thioph-gly-beta3quin
65: bhs-25methiaz-gly-betamethioph
66: tolhs-ithiadiaz-gly-betafbph
67: phhs-25methiaz-gly-betamethi
68: ibhs-24thiaz-gly-betadtrif
69: bhs-24thioph-gly-betabthioph
70: tolhs-25oxaz-gly-betabmph
71: ibhs-ithiadiaz-bala-suabu
72: bhs-42oxaz-gly-betapy

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-28
73: tolhs-ithiadiaz-g1y-betapyr
74: 2py-24im-g ly-psdap
75: thpy-24thiaz-gly-betadcph
76: phhs-24thiaz-gly-betampy
77: bhs-25methiaz-bala-betadito
78: phhs-25methiaz-bala-suabu
79: bhs-25thiaz-bala-beta23meoph
80: bhs-oxadiaz-leu-betapy
81: tolhs-25oxaz-gly-betabnaphth
82: dhim-25thiaz-ala-zdap
83: tolhs-ithiadiaz-gly-betaimid
84: bhs-ithiadiaz-bala-betaoxaz
85: bim-25thioph-ala-betameph
86: phhs-25oxaz-bala-beta4bph
87: bhs-nme35pyr-nmgly-betainyl
88: phhs-24thiaz-bala-betacbph
89: bhs-25oxaz-bala-betaet
90: bhs-24thioph-bala-betabmph
91: bhs-25oxaz-ala-betaanaphth
92: ibhs-ithiadiaz-gly-betathiobe
93: bhs-25thiaz-bala-betadito
94: 2py-nme35pyr-bala-betapy
95: tolhs-25oxaz-bala-beta3quin
96: bhs-25thiaz-gly-beta23meoph
97: 2py-25methiaz-gly-betadito
98: ibhs-nme35pyr-bala-betahni
99: tolhs-nme35pyr-gly-betadmph
100:ibhs-ithiadiaz-bala-betabdimo
101:2py-24thiaz-gly-aspibua
102:ibhs-nme35pyr-bala-betacbph
103;bhs-24thiazme-gly-zdap
104:bhs-24thioph-bala-betaol
105:2py-24im-gly-zdap
106:tolhs-25methiaz-gly-betapytb
107:tolhs-ithiadiaz-gly-psdap
108:phhs-25thiaz-bala-betabthioph
109:bhs-nme35pyr-gly-betafph

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WO 00!66618 PCTIEP00103469
-29
110:bhs-25methiaz-ala-betadhbfu
111:bim-25fur-ala-psdap
112:2pmhs-24thiaz-gly-betapy
113:bhs-24thiaz-bala-betaphethio
114:bhs-25methiaz-bala-betapytb
115:bhs-25methiaz-bala-betambiph
116:ibhs-25thiaz-gly-betainyl
117:phhs-nme35pyr-bala-betabthioph
118:bhs-25thiaz-bala-betacph
119:bim-26py-ala-betadcph
120:phhs-24thioph-gly-betaphethio
121:gua-24thiaz-gly-betabthioph
122:phhs-24thioph-bala-betaph
123:bhs-25thiaz-gly-betaibph
124:ibhs-nme35pyr-bala-betathio3
125:tolhs-oxadiaz-gly-betapy
126:tolhs-nme35pyr-bala-beta4bph
127:2py-me24oxaz-gly-betadcph
128:tolhs-25methiaz-bala-psdapee
129:bhs-ithiadiaz-gly-suabu
130:ibhs-25methiaz-bala-beta3quin
131:phhs-25oxaz-gly-betaipr
132:bim-53pyrazo-ala-betadcph
133:tolhs-25oxaz-gly-betapym
134:phhs-25oxaz-gly-betathiobe
135:phhs-me24thioph-ala-betaph
136:tolhs-me25thiaz-leu-betapy
137:hs-25thiaz-bala-betapy
138:bim-42nmeim-leu-betapy
139:tolhs-nme35pyr-bala-betampy
140:bhs-24thioph-gly-betahdcph
141:ibhs-25oxaz-gly-betaimid
142:bhs-oxadiaz-gly-csdap
143:ibhs-25oxaz-gly-betadtrif
144:2py-53pyrazo-ala-betapy
145:phhs-nme35pyr-gly-betahdbph
146:tolhs-oxadiaz-bala-zdapch

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-30
147:phhs-oxadiaz-bala-betapych
148:bim-24thioph-gly-betatrif
149:tolhs-25methiaz-bala-betapyr
150:2py-24thiaz-ala-betapy
151:bhs-25thiaz-gly-betapytb
152:tolhs-25oxaz-gly-zdapch
153:bhs-25methiaz-ala-betadcph
154:ibhs-25methiaz-gly-betatos
155:tolhs-25thiaz-gly-beta35dbph
156:bim-me24thioph-leu-betadcph
157:bim-nme35pyr-gly-aspbzla
158:ibhs-24thioph-bala-ibsdap
159:gua-24thiaz-gly-betal3bendi
160:2py-25meth iaz-g ly-psda
p
161:2py-24thiaz-bala-asppha
162:ibhs-ithiadiaz-bala-betaanaphth
163:bhs-nme35pyr-ala-betameph
164:tolhs-oxadiaz-gly-betapym
165:phhs-ithiadiaz-gly-betaph
166:phhs-25methiaz-bala-betadcphtb
167:2pmhs-24thiaz-gly-betaph
168:gua-24oxaz-gly-betafbph
169:bhs-25oxaz-phg-betapy
170:bhs-25methiaz-bala-betahdbph
171:2py-me24thiaz-baia-beta34meoph
172:bhs-25thiaz-bala-betambiph
173:phhs-25methiaz-bala-betadmph
174:bhs-oxadiaz-gly-zdapch
175:dhim-25thioph-gly-betadcph
176:bhs-me25oxaz-gly-zdap
177:ibhs-oxadiaz-gly-betahmo
178:ibhs-25thiaz-gly-betadcph
179:2py-35fur-gly-zdap
180:bhs-24thiaz-ala-beta13bendi
181:bhs-oxadiaz-gly-betadcph
182:phhs-oxadiaz-bala-betah35dc
183:ibhs-oxadiaz-bala-betaet

CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-31 -
184:phhs-nme35pyr-gly-betadmph
185:phhs-me24thioph-bala-betapy
186:tolhs-25oxaz-gly-beta34dcph
187:bim-26py-gly-betameph
188:ibhs-24thiaz-gly-betadcphee
189:phhs-25thiaz-gly-betacbph
190:tolhs-ithiadiaz-gly-betaphethioa
191:bhs-25methiaz-gly-betafu2
192:2pmhs-42nmeim-gly-betabenfu
193:bhs-25methiaz-gly-beta3quin
194:tolhs-25thiaz-bala-betahdcph
195:2py-24thioph-bala-betadcph
196:2py-42nmeim-ala-zdap
197:bim-35thioph-gly-betapy
198:bim-me25thioph-leu-zdap
199:bim-25methiaz-bala-betapy
200:tolhs-25thiaz-bala-betaoxaz
201:phhs-25oxaz-gly-betapbiph
202:tolhs-24thioph-bala-ibsdap
203:bhs-oxadiaz-gly-zdaptb
204:bim-42oxaz-leu-betapy
205.ibhs-25methiaz-gly-zdaptb
206:ibhs-25methiaz-gly-betaol
207:tolhs-ithiadiaz-gly-beta34dcph
208:phhs-ithiadiaz-gly-betacthioph
209:phhs-24thiaz-bala-betahmofu
210:phhs-ithiadiaz~ly-aspibua
211:phhs-24thiaz-gly-betathioph
212:bhs-25methiaz-gly-betaimid
213:gua-25thiaz-gly-betahdcph
214:bhs-25thiaz-ala-betacph
215:gua-24thiaz-gly-betaet
216:tolhs-25methiaz-bala-betahcbph
217:tolhs-ithiadiaz-gly-beta35dbph
218:ibhs-oxadiaz-gly-betadbph
219:tolhs-24thioph-gly-betathioph
220:bim-53pyrazo-bala-zdap

CA 02371604 2001-10-24
WO 00166618 PCTIEPOOJ03469
-32
221: bim-me24oxaz-gly-betadcph
222: bim-triaz-gly-psdap
223: phhs-25thiaz-bala-betampy
224: bhs-oxadiaz-gly-betadcphee
225: bim-ithiadiaz-leu-zdap
226: 2pmhs-24thiaz-gly-betafph
227: bhs-25thiaz-gly-betathioph
228: gua-24thiaz-bala-betadcph
229: impy-42nmeim-bala-betafph
10230: tolhs-24thioph-gly-betadmoph
231: ibhs-oxadiaz-bala-betapbiph
232: ibhs-25methiaz-bala-zdapee
233: tolhs-oxadiaz-gly-betafph
234: bhs-me24oxaz-bala-beta34meoph
15235: tolhs-25methiaz-bala-betahbcph
236: bim-42oxaz-leu-betadcph
237: tolhs-oxadiaz-gly-busu2be
238: tolhs-me25thiaz-ala-betapy
239: phhs-oxadiaz-bala-betainyl
20240: bhs-oxadiaz-gly-psdaptb
241: phhs-24thiaz-gly-busu2be
242: tolhs-25methiaz-bala-zdapee
243: bhs-25thiaz-nmgly-betahmph
244: bhs-oxadiaz-gly-betapy
25245: phhs-25oxaz-gly-betadcphee
246: phhs-24thiaz-gly-betapy
247: tolhs-ithiadiaz-bala-betamesu
248: bhs-25oxaz-nmgly-beta13bendi
249: phhs-24thiaz-gly-psdapch
30250: phhs-25oxaz-bala-asppha
251: phhs-25oxaz-bala-beta3quin
252: phhs-25methiaz-gly-beta3quin
253: phhs-me25oxaz-bala-betadcph
254: phhs-me24thiaz-ala-psdap
35255: ibhs-24thioph-gly-betapych
256: phhs-ithiadiaz-bala-betaibph
257: bhs-25oxaz-bala-betaftrif

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-33-
258:bhs-24thiaz-bala-betahc
259:2py-me24thioph-leu-psdap
260:phhs-24thioph-gly-betahc
261:dhim-26py-gly-betaheph
262:phhs-oxadiaz-bala-betaphethio
263:bhs-42nmeim-gly-betahni
264:tolhs-nme35pyr-bala-betahb
265:ibhs-nme35pyr-gly-betathiobe
266:tolhs-25oxaz-gly-betapytb
267:2py-me24oxaz-ala-beta34meoph
268:ibhs-ithiadiaz-gly-betahph
269:bhs-25methiaz-ala-beta13bendi
270:gua-26py-gly-beta3quin
271:phhs-ithiadiaz-gly-betathiobe
272:bhs-oxadiaz-gly-betabpy
273:ibhs-25thiaz-bala-psdapch
274:phhs-ithiadiaz-gly-betacph
275:phhs-24thioph-gly-betabthioph
276:gua-24thiaz-gly-betamesu
277:tolhs-24thiaz-gly-betambiph
278:bhs-me24oxaz-leu-betaph
279:2pmhs-25methiaz-gly-betabpy
280:bhs-ithiadiaz-bala-betathiobe
281:tolhs-25methiaz-bala-betafphe
282:tolhs-24thiaz-bala-betahni
283:ibhs-25thiaz-gly-zdap
284:bhs-25thiaz-ala-betaanaphth
285:ibhs-ithiadiaz-bala-betaphethio
286:ibhs-25oxaz-gly-betaheph
287:2py-me25thioph-leu-zdap
288:phhs-me24thiaz-bala-betaph
289:bim-me25thioph-bala-betapy
290:2py-25thiaz-bala-betapy
291:phhs-25thiaz-bala-betatbuph
292:bhs-24thioph-ala-beta13bendi
293:tolhs-25methiaz-bala-betathiobe
294:phhs-25thiaz-bala-beta13bendi

CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
-34-
295:bim-nme35pyr-leu-psdap
296:phhs-25methiaz-gly-betatos
297:tolhs-nme35pyr-bala-betaibph
298:phhs-25oxaz-bala-betadcphee
299:hs-24thioph-bala-betapy
300:bim-42nmeim-gly-psdap
301:ibhs-nme35pyr-bala-betambiph
302:bhs-nme35pyr-bala-betahdcph
303:tolhs-ithiadiaz-bala-beta34meoph
304:bhs-25methiaz-ala-betahph
305:bim-53pyrazo-bala-psdap
306:2pmhs-25thiaz-gly-betahb
307:2py-me24thiaz-leu-betadcph
308:gua-24thiaz-gly-betahmph
309:ibhs-nme35pyr-gly-betaimid
310:phhs-24thiaz-bala-zdaptb
311:tolhs-24thiaz-gly-betaph
312:gua-24thiaz-gly-betahdcph
313:bhs-25methiaz-bala-betapyee
314:2py-42nmeim-gly-csdap
315:bhs-25oxaz-ala-betadito
316:bhs-nme35pyr-gly-betafu3
317:ibhs-25oxaz-bala-betahdbph
318:phhs-nme35pyr-gly-betabmph
319:phhs-ithiadiaz-bala-betapych
320:bim-24thiaz-leu-psdap
321:bhs-oxadiaz-bala-betadcphee
322:tolhs-ithiadiaz-bala-betaol
323:gua-42pym-gly-betabediox
324:bim-24thiaz-gly-asppha
325:tolhs-24thiaz-gly-betahmofu
326:ibhs-oxadiaz-gly-beta23meoph
327:phhs-me24thioph-ala-zdap
328:phhs-me24oxaz-gly-betaph
329:bhs-25oxaz-nmgly-beta23meoph
330:tolhs-ithiadiaz-bala-betadbph
331:bhs-24im-bala-zdap

CA 02371604 2001-10-24
WO 00/66618 PCTlEP00103469
-35-
332:phhs-oxadiaz-gly-busu2be
333:ibhs-25methiaz-bala-betathio3
334:tolhs-24thiaz-bala-betabdimo
335:bhs-25oxaz-bala-betaipr
336:2py-me25thiaz-ala-betaph
337:bhs-25methiaz-gly-betapyr
338:tolhs-25oxaz-bala-betainyl
339:ibhs-25oxaz-gly-betaoxaz
340:tolhs-25thiaz-gly-betapyr
341:phhs-25methiaz-bala-betacbph
342:bhs-24thioph-gly-betadmoph
343:tolhs-oxadiaz-bala-aspbzla
344:dhim-25thioph-gly-zdap
345:phhs-25oxaz-bala-betafph
346:tolhs-25methiaz-bala-betaoxaz
347:ibhs-nme35pyr-bala-aspbzla
348:bhs-oxadiaz-bala-betahcbph
349:phhs-oxadiaz-gly-betameph
350:phhs-me24thioph-leu-betadcph
351:ibhs-nme35pyr-gly-busu2be
352:dhim-24oxaz-ala-zdap
353:2py-me24oxaz-ala-betaph
354:phhs-ithiadiaz-gly-betampy
355:bhs-ithiadiaz-gly-psdap
356:ibhs-24thioph-gly-aspbzla
357:bim-ithiadiaz-leu-psdap
358:dhim-24thiaz-gly-betahdcph
359:bim-me25oxaz-ala-betadcph
360:gua-24thiaz-gly-betaoxope
361:bim-nme35pyr-ala-betadcph
362:phhs-24thioph-bala-betabthioph
363:2py-25methiaz-bala-aspbzla
364:tolhs-nme35pyr-gly-betaet
365:bhs-52thiaz-gly-zdap
366:ibhs-oxadiaz-gly-betafbph
367:bhs-24thiaz-gly-betafu3
368:bim-25thiaz-gly-betapy

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-36-
369: bhs-24thiaz-gly-betah35dc
370: tolhs-24thiaz-bala-aspibua
371: tolhs-24thioph-bala-betadhbfu
372: tolhs-24thioph-gly-psdapee
373: ibhs-25thiaz-bala-betapym
374: bhs-52thiaz-ala-betainyl
375: ibhs-25oxaz-bala-betadtrif
376: ibhs-ithiadiaz-gly-betamethioph
377: tolhs-25methiaz-gly-betabpy
10378: ibhs-25methiaz-bala-beta35dbph
379: ibhs-25oxaz-bala-beta35dbph
380: bhs-me25thiaz-bala-zdap
381: bhs-25oxaz-gly-asppha
382: bhs-25methiaz-bala-betaphethio
15383: bim-42oxaz-bala-betadcph
384: ibhs-24thiaz-bala-beta3quin
385: bhs-25methiaz-gly-betadcphtb
386: bhs-ithiadiaz-gly-betadcphtb
387: ibhs-25oxaz-bala-betafph
20388: tolhs-24thioph-gly-betahmo
389: bhs-24thioph-bala-betafbph
390: phhs-24thiaz-bala-beta13bendi
391: 2py-24oxaz-bala-zdap
392: phhs-nme35pyr-gly-betadbph
25393: bhs-25methiaz-bala-betacph
394: tolhs-25oxaz-gly-betamethioph
395: ibhs-24thiaz-bala-betambiph
396: bhs-24thioph-nmgly-ibsdap
397: phhs-nme35pyr-bala-betahmph
30398: dhim-52thiaz-ala-betameph
399: tolhs-oxadiaz-gly-beta3quin
400: bhs-25methiaz-nmgly-betaoxaz
401: bhs-oxadiaz-ala-betafphe
402: phhs-25methiaz-gly-betafluo
35403: bhs-25oxaz-leu-betadcph
404: tolhs-25methiaz-gly-betaipr
405: dhim-26py-gly-betahcbph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-37
406:bhs-25methiaz-gly-zdapee
407:2pmhs-24thioph-gly-betahbcph
408:phhs-ithiadiaz-bala-betahc
409:tolhs-24thiaz-gly-betaipr
410:ibhs-nme35pyr-bala-betainyl
411:bhs-42pym-ala-zdap
412:bhs-25oxaz-bala-betaphethio
413:impy-25thiaz-gly-betahmofu
414:bhs-25thiaz-bala-betadmph
415:tolhs-me25thioph-ala-betaph
416:bim-24thioph-gly-aspbzla
417:tolhs-nme35pyr-gly-betaheph
418:phhs-25oxaz-bala-betatrif
419:tolhs-24thioph-gly-betathiome
420:ibhs-nme35pyr-gly-betathioph
421:ibhs-25methiaz-gly-betambiph
422:bhs-25oxaz-bala-betacthioph
423:ibhs-24thiaz-gly-csdap
424:2py-ithiadiaz-gly-asppha
425:tolhs-25thiaz-gly-betabdimo
426:tolhs-25thiaz-gly-zdap
427:tolhs-25methiaz-bala-betadmoph
428:tolhs-25thiaz-gly-betabediox
429:phhs-25methiaz-gly-betadbph
430:ibhs-oxadiaz-gly-betahni
431:tolhs-24thiaz-bala-betahdbph
432:phhs-25oxaz-gly-betadmoph
433:phhs-24thiaz-gly-betaomebendi
434:tolhs-ithiadiaz-bala-zdapee
435:tolhs-25oxaz-gly-betathiobe
436:phhs-25oxaz-bala-betaibph
437:2py-25oxaz-leu-zdap
438:bhs-24oxaz-leu-betadcph
439:bhs-nme35pyr-ala-psdap
440:phhs-oxadiaz-bala-betabediox
441:tolhs-oxadiaz-bala-betapbiph
442:2py-ithiadiaz-bala-aspaba

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-38
443:tolhs-24thiaz-bala-psdaptb
444:bhs-24thiaz-gly-busu2be
445:ibhs-25thiaz-gly-betaoxaz
446:bhs-24thioph-gly-betaphethio
447:bim-35thioph-bala-betapy
448:dimethpym-25methiaz-gly-betameph
449:2py-ithiadiaz-bala-zdap
450:bhs-25thiaz-nmgly-betabpy
451:2py-35fur-ala-betapy
452:phhs-25oxaz-gly-betamethioph
453:tolhs-me24thioph-bala-betapy
454:tolhs-ithiadiaz-gly-betafu3
455:gua-26py-gly-betaimid
456:phhs-nme35pyr-bala-betaphethio
457:bhs-25oxaz-gly-aspibua
458:ibhs-oxadiaz-gly-betafph
459:ibhs-oxadiaz-gly-betafu3
460:ibhs-24thiaz-bala-betahcbph
461:tolhs-24thioph-gly-betafluo
462:2py-24thioph-leu-betapy
463:impy-25oxaz-gly-ibsdap
464:phhs-nme35pyr-gly-aspbzla
465:4pmhs-42nmeim-bala-betadcph
466:tolhs-me25thioph-leu-beta34meoph
467:phhs-oxadiaz-gly-betaoxaz
468:tolhs-nme35pyr-gly-betamethioph
469:bhs-25thiaz-gly-betaheph
470:phhs-nme35pyr-bala-betaoxaz
471:bhs-24thioph-nmgly-betacph
472:bim-me25oxaz-ala-beta34meoph
473:bhs-25methiaz-gly-betacbph
474:impy-25methiaz-gly-betahmofu
475:dhim-35pyrazo-gly-betameph
476:bim-35fur-ala-zdap
477:phhs-25oxaz-gly-betahc
478:bhs-24thioph-bala-aspibua
479:2py-24thiaz-gly-betacthioph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-39
480: bhs-oxadiaz-bala-suabu
481: bhs-25methiaz-gly-aspaba
482: tolhs-nme35pyr-gly-betaipr
483: 2py-ithiadiaz-ala-psdap
484: ibhs-ithiadiaz-bala-betathiobe
485: bhs-nme35pyr-bala-betapyee
486: tolhs-25methiaz-bala-betahc
487: tolhs-25oxaz-gly-zdaptb
488: bhs-24thioph-gly-beta23meoph
10489: tolhs-24thioph-bala-betaphethioa
490: bhs-nme35pyr-bala-betahbcph
491: phhs-25oxaz-gly-betadbph
492: bhs-25methiaz-bala-asppha
493: ibhs-nme35pyr-gly-psdapch
15494: bhs-oxadiaz-bala-ibsdap
495: bhs-25methiaz-bala-betapy
496: ibhs-24thiaz-gly-betabdimo
497: ibhs-24thiaz-bala-beta34dcph
498: phhs-oxadiaz-gly-betadcphch
20499: bim-nme35pyr-gly-betadcph
500: bhs-ithiadiaz-gly-betahc
501: ibhs-ithiadiaz-bala-betathiome
502: bim-me24oxaz-leu-zdap
503: bhs-25oxaz-gly-betadcphee
25504: bim-25fur-leu-psdap
505: tolhs-oxadiaz-bala-betatbuph
506: gua-42pym-gly-betadbph
507: ibhs-24thioph-gly-aspaba
508: ibhs-25methiaz-gly-beta34dcph
30509: tolhs-ithiadiaz-bala-betahbcph
510: bhs-oxadiaz-nmgly-betaoxaz
511: tolhs-25thiaz-bala-betadbph
512: bhs-oxadiaz-bala-betaomebendi
513: thpym-24thiaz-gly-betameph
35514: bhs-ithiadiaz-bala-beta35dbph
515: 2pmhs-25thiaz-gly-betadtrif
516: ibhs-ithiadiaz-bala-psdapch

CA 02371604 2001-10-24
WO 00!6661$ PCTlEP00l03469
- 40 -
517: phhs-24thioph-bala-betaanaphth
518: bhs-25thiaz-bala-betaet
519: ibhs-ithiadiaz-bala-betahdcph
520: bhs-42oxaz-ala-zdap
521: tolhs-24thioph-gly-busu2be
522: bhs-ithiadiaz-gly-betaftrif
523: tolhs-nme35pyr-gly-betadhbfu
524: bhs-24thiaz-gly-aspibua
525: bhs-24thioph-gly-betapy
10526: ibhs-25oxaz-gly-aspbzla
527: tolhs-24thioph-bala-betadbph
528: phhs-25methiaz-gly-betabenfu
529: bhs-nme35pyr-ala-betadito
530: phhs-me25thiaz-ala-beta34meoph
15531: ibhs-25methiaz-bala-betamethi
532: ibhs-25oxaz-gly-betahmofu
533: bhs-24thioph-gly-zdapch
534: phhs-24thioph-bala-betah35dc
535: ibhs-24thioph-bala-betahcbph
20536: ibhs-ithiadiaz-bala-betahph
537: bhs-ithiadiaz-bala-asppha
538: dhim-25thioph-gly-betameph
539: tolhs-ithiadiaz-gly-betadcphee
540: phhs-oxadiaz-bala-betatbuph
25541: bhs-25thiaz-gly-betamethi
542: bhs-ithiadiaz-gly-betahbcph
543: tolhs-25oxaz-bala-betadcphtb
544: phhs-24thiaz-gly-betadhbfu
545: ibhs-25oxaz-gly-psdap
30546: ibhs-25methiaz-bala-betatrif
547: bhs-ithiadiaz-bala-beta23meoph
548: phhs-25thiaz-gly-betahmofu
549: bhs-24thioph-gly-betamethi
550: ibhs-25oxaz-gly-betadito
35551: bhs-25methiaz-gly-betadcph
552: bhs-me24thioph-ala-psdap
553: tolhs-25thiaz-gly-betahni

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-41 -
554:ibhs-24thioph-gly-betafu3
555:phhs-24thiaz-gly-betahni
556:2py-24thioph-gly-aspbzla
557:ibhs-nme35pyr-gly-betaibph
558:tolhs-25methiaz-gly-psdapch
559:bhs-ithiadiaz-gly-betaet
560:bhs-nme35pyr-ala-beta34meoph
561:phhs-oxadiaz-gly-betapyr
562:ibhs-25oxaz-gly-zdapch
563:bhs-24oxaz-ala-betainyl
564:ibhs-nme35pyr-gty-betahmo
565:bhs-25thiaz-nmgly-beta34dcph
566:bhs-nme35pyr-bala-betaomebendi
567:tolhs-25oxaz-gly-betaph
568:bhs-24thiaz-nmgly-betahph
569:bhs-nme35pyr-leu-psdap
570:ibhs-24thioph-gly-betahni
571:ibhs-25oxaz-gly-betaftrif
572:phhs-me24thiaz-leu-zdap
573:ibhs-24thiaz-gly-betathiobe
574:phhs-25oxaz-bala-betabediox
575:phhs-ithiadiaz-gly-betameph
576:tolhs-ithiadiaz-gly-psdaptb
577:2py-me25oxaz-leu-zdap
578:dhim-24oxaz-gly-zdap
579:tolhs-oxadiaz-gly-betapbiph
580:tolhs-24thioph-gly-betadcphch
581:bhs-ithiadiaz-bala-psdapee
582:imhs-25methiaz-gly-zdap
583:bhs-25oxaz-gly-betabnaphth
584:bhs-24thiaz-gly-betaftrif
585:phhs-25methiaz-gly-betahmofu
586:phhs-ithiadiaz-bala-betamethi
587:bhs-ithiadiaz-gly-betabdimo
588:dhim-42pym-gly-betainyl
589:bhs-25thioph-bala-betadcph
590:2py-thiadiaz-leu-betapy

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-42
591:tolhs-25oxaz-bala-betabmph
592:phhs-25oxaz-gly-betadito
593:bim-ithiadiaz-gly-psdap
594:phhs-24thioph-gly-betaibph
595:tolhs-25oxaz-gly-psdapee
596:ibhs-25methiaz-gly-betamesu
597:bhs-oxadiaz-bala-aspaba
598:bhs-oxadiaz-bala-betapym
599:phhs-24thioph-gly-betafu3
600:tolhs-24thioph-gly-betaphethioa
601:ibhs-25oxaz-bala-betafphe
602:tolhs-25oxaz-gly-betacbph
603:ibhs-25methiaz-bala-betaipro
604:bhs-nme35pyr-gly-betaipro
605:tolhs-24thioph-bala-betahmph
606:tolhs-25methiaz-bala-betadbph
607:bhs-25methiaz-gly-betaamibe
608:impy-24thiaz-gly-betabediox
609:ibhs-oxadiaz-gly-betapym
610:2py-25methiaz-ala-betapy
611:tolhs-nme35pyr-bala-betabnaphth
612:phhs-24thioph-gly-beta4bph
613:ibhs-ithiadiaz-bala-betah35dc
614:bhs-oxadiaz-gly-betaomebendi
615:tolhs-25methiaz-gly-betafph
616:phhs-25oxaz-bala-betadcphtb
617:ibhs-ithiadiaz-gly-beta35dbph
618:2py-25oxaz-bala-betadhbfu
619:bhs-25oxaz-gly-betatrif
620:ibhs-25thiaz-gly-zdapch
621:bhs-oxadiaz-gly-betadmoph
622:phhs-nme35pyr-bala-betacthioph
623:phhs-25thiaz-bala-betavxaz
624:bim-me25oxaz-gly-psdap
625:bhs-25methiaz-ala-betapy
626:ibhs-24thioph-bala-betathioph
627:phhs-25methiaz-gly-suabu

CA 02371604 2001-10-24
WO 00/66618 PCTIEP00I034fi9
-43-
628:phhs-ithiadiaz-bala-betacph
629:phhs-25methiaz-gly-betadmoph
630:phhs-ithiadiaz-bala-zdapch
631:phhs-24thiaz-gly-betabediox
632:bhs-nme35pyr-bala-betatos
633:tolhs-25oxaz-bala-betaipr
634;bhs-24thioph-gly-betapytb
635:bhs-25methiaz-leu-betapy
636:4pmhs-24thiaz-gly-betapy
637:tolhs-oxadiaz-bala-betapytb
638:tolhs-oxadiaz-gly-beta34meoph
639:bhs-25oxaz-bala-betatbuph
640:ibhs-25oxaz-gly-suabu
641:phhs-25methiaz-gly-psdaptb
642:tolhs-25oxaz-bala-betahph
643:ibhs-nnme35pyr-gly-betabmph
644:bhs-25oxaz-gly-betadmph
645:ibhs-25oxaz-bala-betabpy
646:phhs-me24thioph-gly-betadcph
647:tolhs-24thioph-bala-betathio3
648:ibhs-25methiaz-bala-psdap
649:bim-25thiaz-gly-psdap
650:ibhs-25methiaz-gly-betahbcph
651:ibhs-ithiadiaz-gly-betacbph
652:ibhs-25methiaz-gly-betabthioph
653:bim-me24thioph-gly-betadcph
654:bhs-oxadiaz-bala-betatos
655:phhs-nme35pyr-gly-betabdimo
656:gua-26py-gly-betahmofu
657:ibhs-24thioph-gly-psdaptb
658:phhs-25oxaz-bala-betainyl
659:phhs-24thiaz-bala-betameph
660:bim-25thioph-bala-zdap
661:tolhs-25oxaz-bala-betahmo
662:tolhs-ithiadiaz-gly-betacbph
663:tolhs-25methiaz-bala-beta34meoph
664:bhs-24im-gly-betameph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-44-
665:tolhs-oxadiaz-gly-betadcphee
666:phhs-25thiaz-gly-betadmph
667:bhs-nme35pyr-ala-betadmoph
668:ibhs-24thiaz-gly-betafphe
669:circa-25oxaz-gly-betameph
670:phhs-25oxaz-gly-betatos
671:phhs-25methiaz-bala-beta3quin
672:bim-24oxaz-ala-zdap
673:ibhs-25methiaz-gly-csdap
674:phhs-ithiadiaz-bala-betafph
675:dhim-52thiaz-gly-psdap
676:bhs-24thiaz-ala-zdap
677;ibhs-ithiadiaz-bala-aspibua
678:ibhs-oxadiaz-bala-betahmofu
679:phhs-24thioph-bala-betaoxaz
680:phhs-25oxaz-bala-busu2be
681:tolhs-25oxaz-bala-ibsdap
682:ibhs-24thioph-gly-betacph
683:bhs-35thioph-ala-betameph
684:2py-25thioph-gly-betainyl
685:bim-nme35pyr-ala-betapy
686:2py-25thiaz-bala-aspaba
687:bhs-24thioph-gly-betabenfu
688:phhs-nme35pyr-bala-betabph
689:ibhs-oxadiaz-gly-betatos
690:phhs-ithiadiaz-gly-betamesu
691:2pmhs-25oxaz-bala-betabnaphth
692:tolhs-25methiaz-bala-busu2be
693:tolhs-25oxaz-gly-betapyr
694:bhs-ithiadiaz-gly-beta34meoph
695:phhs-24thioph-bala-betampy
696:tolhs-nme35pyr-gly-busu2be
697:bhs-25oxaz-gly-psdap
698:phhs-25oxaz-gly-betaph
699:phhs-me25oxaz-gly-zdap
700:bhs-24thioph-gly-betahc
701:ibhs-25thiaz-gly-beta23meoph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-45
702:phhs-25methiaz-gly-betabnaphth
703:phhs-24thioph-gly-betabpy
704:tolhs-25oxaz-bala-betatbuph
705:bhs-24thiaz-gly-zdaptb
706:gua-26py-gly-betaph
707:tolhs-me25thiaz-bala-betadcph
708:phhs-24thiaz-bala-betabediox
709:ibhs-25methiaz-gly-betathiobe
710:phhs-24thiaz-gly-beta3quin
711:tolhs-25oxaz-gly-betadmph
712:dhpyrr-25thioph-gly-betadcph
713:phhs-ithiadiaz-gly-betahb
714:hts-42nmeim-gly-zdap
715:dhim-24thiaz-gly-zdap
716:bhs-24thioph-ser-betapy
717:2py-25fur-bala-betadcph
718:bhs-4.2nmeim-bala-betaol
719:bhs-25methiaz-bala-betafphe
720:ibhs-25thiaz-bala-betaipr
721:2py-24thiaz-bala-aspaba
722:phhs-me25thiaz-ala-betadcph
723:phhs-oxadiaz-bala-betadmph
724:tolhs-ithiadiaz-bala-betapych
725:phhs-25oxaz-bala-betapych
726:tolhs-24thiaz-bala-betadbph
727:ibhs-25methiaz-gly-betabenfu
728:bhs-25methiaz-gly-beta4bph
729:bhs-ithiadiaz-gly-betameph
730:phhs-24thioph-bala-betabenfu
731:bhs-25methiaz-nmgly-ibsdap
732:bhs-oxadiaz-gly-betacbph
733:bhs-nme35pyr-gly-betaftrif
734:phhs-25oxaz-gly-suabu
735:bhs-25methiaz-nmgly-betaanaphth
736:bhs-ithiadiaz-bala-betadbph
737:bim-me25oxaz-gly-betaph
738:phhs-24thioph-gly-betaoxaz

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-46
739: bhs-42oxaz-gly-zdap
740: bhs-24thiaz-nmgly-betahmph
741: ibhs-ithiadiaz-bala-betapytb
742: bhs-25methiaz-nmgly-betafphe
743: bhs-oxadiaz-ala-beta34meoph
744: bim-53pyrazo-ala-zdap
745: phhs-25methiaz-gly-betadcph
746: phhs-24thioph-gly-zdaptb
747: hts-25oxaz-bala-betadcph
10748: 2py-ithiadiaz-ala-betadcph
749: bim-nme35pyr-gly-betapy
750: phhs-oxadiaz-gly-betatrif
751: ibhs-24thiaz-bala-betabnaphth
752: 2py-25methiaz-gly-beta3quin
15753: phhs-oxadiaz-bala-betapbiph
754: tolhs-25thiaz-gly-betatrif
755: bim-53pyrazo-gly-betapy
756: bhs-ithiadiaz-nmgly-betabnaphth
757: phhs-25thiaz-gly-betadtrif
20758: phhs-nme35pyr-gly-psdapch
759: tolhs-25thiaz-bala-betaomebendi
760: phhs-24thiaz-gly-betaoxope
761: ibhs-oxadiaz-gly-betathio3
762: phhs-oxadiaz-gly-betaph
25763: phhs-oxadiaz-bala-betabph
764: bim-me25thiaz-bala-betaph
765: ibhs-oxadiaz-bala-beta4bph
766: bim-me25thiaz-leu-zdap
767: 2py-25methiaz-ala-psdap
30768: bhs-42oxaz-ala-betadcph
769: bhs-25methiaz-gly-betainyl
770: bim-triaz-gly-betadcph
771: tolhs-24thiaz-bala-betabthioph
772: bhs-nme35pyr-bala-busu2be
35773: bhs-25oxaz-nmgly-betainyl
774: phhs-me25thiaz-gly-betapy
775: bhs-ithiadiaz-gly-beta4bph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-47
776: phhs-me25thiaz-bala-betadcph
777: bhs-25thiaz-gly-zdap
778: phhs-24thiaz-bala-betah35dc
779: tolhs-nme35pyr-bala-betahmofu
780: bhs-24thiaz-bala-betabdimo
781: bim-ithiadiaz-gly-zdap
782: ibhs-24thioph-gly-betadbph
783: bhs-me25oxaz-g1y-betapy
784: bhs-24thiaz-ala-beta23meoph
10785: ibhs-nme35pyr-bala-betapytb
786: bhs-25oxaz-gly-betaamibe
787: bhs-ithiadiaz-gly-betaoxope
788: gua-25thioph-gly-betacthioph
789: bhs-oxadiaz-gly-betapyr
15790: phhs-me25oxaz-ala-beta34meoph
791: bhs-ithiadiaz-gly-betadrnph
792: bim-25methiaz-bala-betaimid
793: ibhs-oxadiaz-bala-betameph
794: ibhs-oxadiaz-bala-betahph
20795: phhs-24thioph-gly-betathio3
796: tolhs-nme35pyr-bala-betapyr
797: ibhs-ithiadiaz-gly-betamethi
798: phhs-24thiaz-bala-beta3quin
799: ibhs-nme35pyr-gly-betaipro
25800: ibhs-oxadiaz-gly-aspbzla
801: bhs-25thiaz-bala-betamesu
802: bim-35fur-bala-zdap
803: tolhs-nme35pyr-gly-betabph
804: phhs-ithiadiaz-bala-betaphethioa
30805: ibhs-nme35pyr-gly-ibsdap
806: bim-24thiaz-feu-betapy
807: thpy-25methiaz-gly-betadcph
808: phhs-24thioph-gly-betabenfu
809: ibhs-25methiaz-gly-betapych
35810: ibhs-oxadiaz-gly-betaph
811: bhs-25thiaz-gly-betaftrif
812: phhs-nme35pyr-bala-betapym

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-48
813:tolhs-25thiaz-gly-betameph
814:2py-25methiaz-bala-betaheph
815:2py-25methiaz-gly-aspaba
816:phhs-24thiaz-bala-betapych
817:bhs-35fur-bala-betadcph
818:phhs-ithiadiaz~ly-suabu
819:2py-42pym-gly-zdap
820:ibhs-ithiadiaz-gly-betaimid
821:tolhs-25oxaz-gly-betahdbph
822:ibhs-25oxaz-bala-betahbcph
823:ibhs-ithiadiaz-bala-betaoxope
824:tolhs-oxadiaz-gly-ibsdap
825:tolhs-nme35pyr-bala-betabenfu
826:bhs-24thioph-gly-betaphethioa
827:bhs-me25thiaz-bala-betadcph
828:tolhs-me24oxaz-bala-betaph
829:phhs-ithiadiaz-bala-betafbph
830:ibhs-24thioph-gly-betabediox
831:tolhs-me25thioph-bala-zdap
832:tolhs-oxadiaz-bala-betapym
833:bhs-25oxaz-gly-zdaptb
834:ibhs-ithiadiaz-bala-beta13bendi
835:bhs-nme35pyr-bala-betatbuph
836:phhs-oxadiaz-gly-betaphethioa
837:dhim-thiadiaz-gly-betameph
838:bhs-24thioph-nmgly-betacthioph
839:phhs-25methiaz-bala-betaoxaz
840:ibhs-24thiaz-gly-betaimid
841:phhs-24thioph-bala-betabnaphth
842:bhs-24im-bala-betapy
843:toihs-24thiaz-gly-betabph
844:2py-25meth iaz-g ly-aspbzla
845:2pmhs-25thiaz-phe-zdap
846:2pm hs-24th iaz-g
ly-betahb
847:bhs-24thiaz-gly-betambiph
848:phhs-25oxaz-gly-psdapch
849:ibhs-24thiaz-gly-beta4bph

CA 02371604 2001-10-24
WO 00/66618 PCT/EP00103469
-49-
850: bim-ithiadiaz-bala-betadcph
851: tolhs-25thiaz-gly-betahdcph
852: bhs-ithiadiaz-bala-betamethioph
853: ibhs-25oxaz-gly-ibsdap
854: ibhs-25oxaz-gly-betabthioph
855: bhs-25methiaz-leu-psdap
856: bhs-25thiaz-bala-betabph
857: tolhs-nme35pyr-bala-betaanaphth
858: bim-me24thioph-leu-betaph
859: thpy-42pym-gly-betadcph
860: thpy-25oxaz-bala-zdap
861: ibhs-ithiadiaz-bala-betahmofu
862: ibhs-oxadiaz-gly-betabph
863: bhs-24thiaz-bala-beta13bendi
864: dhim-24oxaz-ala-betainyl
865: tolhs-nme35pyr-gly-betaoxaz
866: tolhs-oxadiaz-gly-betathio3
867: bhs-25fur-gly-zdap
868: bim-24im-ala-psdap
869: ibhs-nme35pyr-bala-betabmph
870: bhs-ithiadiaz-ala-betathio3
871: tolhs-25thiaz-gly-beta34meoph
872: tolhs-24thioph-gly-betahmofu
873: phhs-25oxaz-gly-zdap
874: 2pmhs-42nmeim-bala-betabph
875: tolhs-25oxaz-bala-busu2be
876: phhs-ithiadiaz-gly-betathioph
877: bhs-25fur-ala-psdap
878: tolhs-25methiaz-bala-betaphethio
879: phhs-oxadiaz-bala-betathiobe
880: ibhs-24thioph-gly-betaibph
881: tolhs-25thiaz-gly-betadito
882: tolhs-25thiaz-gly-betahc
883: tolhs-24thiaz-bala-betabenfu
884: 2py-25thiaz-bala-aspibua
885: impy-25thiaz-gly-betaipr
886: phhs-ithiadiaz-bala-beta35dbph

CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-50-
887: phhs-25thiaz-bala-suabu
888: phhs-24thiaz-bala-betapym
889: dhim-52thiaz-gly-zdap
890: ibhs-24thioph-bala-betathiome
891: bim-42nmeim-bala-betadcph
892: tolhs-ithiadiaz-gly-betaoxaz
893: phhs-25thiaz-bala-betamethi
894: phhs-24thiaz-gly-betaphethioa
895: bhs-ithiadiaz-ala-betacthioph
896: phhs-nme35pyr-bala-betahbcph
897: phhs-me24thiaz-bala-betadcph
898: hs-25oxaz-gly-betadcph
899: ibhs-25oxaz-gly-beta3quin
900: tolhs-24thioph-bala-betaibph
901: tolhs-24thioph-bala-betahb
902: thazep-24thiaz-gly-betapy
903: ibhs-nme35pyr-bala-beta3quin
904: tolhs-25oxaz-bala-betaamibe
905: bhs-oxadiaz-ala-zdap
906: tolhs-24thioph-bala-beta4bph
907: phhs-ithiadiaz-bala-betapbiph
908: gua-42pym-gly-betafph
909: phhs-nme35pyr-gly-betatbuph
910: tolhs-nme35pyr-bala-beta34dcph
911: phhs-24thiaz-bala-aspibua
912: 2py-25thioph-ala-betameph
913: bim-me25thioph-leu-beta34meoph
914: 2py-me25oxaz-leu-betapy
915: 2py-24thioph-gly-aspibua
916: ibhs-25oxaz-gly-betadcphtb
917: gua-42pym-gly-betadcph
918: bhs-24thiaz-bala-betadcphee
919: tolhs-25oxaz-bala-psdapee
920: tolhs-oxadiaz-bala-betaftrif
921: ibhs-oxadiaz-gly-betatbuph
922: bhs-me24oxaz-ala-betadcph
923: tolhs-ithiadiaz-bala-betafu3

CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-51
924:ibhs-24thioph-bala-zdaptb
925:phhs-25thiaz-bala-betadbph
926:2py-42oxaz-leu-zdap
927:bhs-oxadiaz-bala-betahmofu
928:ibhs-25methiaz-gly-betathiome
929:phhs-nme35pyr-bala-betadito
930:phhs-24thioph-gly-beta34meoph
931:tolhs-nme35pyr-bala-betainyl
932:phhs-me24thioph-gly-beta34meoph
933:bim-me25thiaz-gly-betadcph
934:bhs-24thiaz-ala-csdap
935:phhs-24thioph-gly-aspbzla
936:bim-25thiaz-gly-betatrif
937:impy-24thioph-gly-betacbph
938:dhpyrr-25methiaz-gly-betapy
939:bhs-24thiaz-bala-betadmoph
94~:bhs-42pym-gly-psdap
941:phhs-ithiadiaz-bala-betapyee
942:phhs-24thioph-bala-betathiobe
943:bim-35thioph-leu-psdap
944:phhs-me24oxaz-leu-betapy
945:phhs-24thioph-bala-betacph
946:ibhs-25methiaz-bala-betatos
947:tolhs-25oxaz-bala-betaoxope
948:gua-24oxaz-gly-betamethioph
949:tolhs-25methiaz-gly-suabu
95Q:phhs-24thiaz-bala-betamethi
951:phhs-ithiadiaz-gly-betadhbfu
952:gua-24thiaz-gly-betadbph
953:bhs-25methiaz-nmgly-betabnaphth
954:bhs-24thioph-leu-betapy
955:phhs-25thiaz-gly-betacthioph
956:bim-25oxaz-bala-aspaba
957:phhs-ithiadiaz-bala-psdapee
958:tolhs-oxadiaz-bala-busu2be
959:phhs-me24thiaz-bala-betapy
960:phhs-me24thioph-leu-beta34meoph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-52-
961:phhs-24thioph-gly-betapbiph
962:bhs-ithiadiaz-bala-beta34dcph
963:bim-me24thiaz-ala-betaph
964:bhs-nme35pyr-bala-psdapch
965:phhs-24thiaz-bala-betabmph
966:phhs-24thiaz-gly-betadmph
967:bim-triaz-ala-zdap
968:thpym-25oxaz-gly-betameph
969:bim-24thiaz-gly-betaibph
970:tolhs-24thiaz-gly-betaheph
971:tolhs-ithiadiaz-gly-zdaptb
'
972:bim-26pyrazi-gly-zdap
973:ibhs-24thioph-gly-betaol
974:bim-me25thiaz-gly-betaph
975:ibhs-25methiaz-bala-betadcphch
976:phhs-24thioph-gly-psdapch
977:phhs-24thioph-gly-betahdbph
978:phhs-me25oxaz-gly-betapy
979:dhim-24thiaz-gly-betadcph
980:bim-me24thiaz-ala-betadcph
981:bhs-nme35pyr-gly-betaomebendi
982:phhs-oxadiaz-bala-psdapee
983:bhs-24thioph-bala-betahc
984:ibhs-24thiaz-bala-betathiobe
985:bhs-25methiaz-gly-beta13bendi
986:phhs-oxadiaz-bala-busu2be
987:phhs-ithiadiaz-gly-betafu3
988:phhs-24thioph-gly-betaimid
989:tolhs-25thiaz-bala-beta35dbph
990:bhs-oxadiaz-gly-betacthioph
991:bhs-ithiadiaz-gly-betapych
992:bim-24oxaz-gly-psdap
993:tolhs-me24thiaz-bala-betapy
994:bhs-25oxaz-gly-betathio3
995:bim-oxadiaz-bala-betadcph
996:phhs-nme35pyr-gly-betafu3
997:dhim-25thiaz-ala-betapy

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-53-
998: agua-25methiaz-gly-psdap
999: bim-nme35pyr-leu-zdap
1000:tolhs-24thiaz-bala-betahmo
1001:bim-35fur-bala-psdap
1002:bhs-24thiaz-gly-betadmoph
1003:dhim-25methiaz-gly-betapy
1004:phhs-25methiaz-gly-betapytb
1005:2py-me25oxaz-leu-beta34meoph
1006:gua-24thiaz-gly-betapym
101007:bim-35fur-leu-zdap
1008:bhs-25thioph-leu-betadcph
1009:ibhs-25thiaz-bala-betameph
1010:bhs-24thioph-gly-psdap
1011:2py-35fur-gly-psdap
151012:ibhs-oxadiaz-bala-busu2be
1013:ibhs-oxadiaz-bala-zdap
1014:bhs-25methiaz-gly-betahb
1015:tolhs-25oxaz-bala-beta4bph
1016:phhs-me24oxaz-bala-beta34meoph
201017:tolhs-25oxaz-gly-beta4bph
1018:bim-35thioph-gly-betadcph
1019:bhs-25oxaz-bala-beta3quin
1020:impy-25thiaz-gly-betabediox
1021:bhs-nme35pyr bala-betabmph
251022:phhs-me24oxaz-gly-beta34meoph
1023:tolhs-24thioph-bala-betaipr
1024:2py-me25thioph-leu-betadcph
1025:ibhs-24thiaz-bala-betaol
1026:ibhs-24thioph-gly-betatos
301027:phhs-25thiaz-gly-betahni
1028:tolhs-24thioph-bala-betamethi
1029:tolhs-24thiaz-gly-betafu2
1030:ibhs-ithiadiaz-gly-betathioph
1031:2py-42nmeim-ala-betadcph
351032:phhs-24thioph-bala-aspibua
1033:2py-25thiaz-gly-zdap
1034:bhs-25thiaz-gly-psdapch

CA 02371604 2001-10-24
WO 00166618 PCTlEP00l03469
-54-
1035:gua-42pym-gly-betadito
1036:ibhs-25oxaz-gly-betahdcph
1037:tolhs-oxadiaz-bala-betathiome
1038:phhs-25thiaz-bala-betaftrif
1039:phhs-ithiadiaz-bala-betabdimo
1040:bhs-nme35pyr-ala-beta13bendi
1041:ibhs-25methiaz-gly-betadtrif
1042:dhim-25thiaz-gly-betainyl
1043:bim-24thiaz-bala-betapy
1044:bhs-25thiaz-nmgly-betathioph
1045:bhs-25thiaz-gly-betatbuph
1046:tolhs-ithiadiaz-gly-aspibua
1047:phhs-ithiadiaz-bala-ibsdap
1048:bhs-24thiaz-bala-zdaptb
1049:ibhs-25methiaz-gly-busu2be
1050:tolhs-oxadiaz-bala-betahmph
1051:phhs-ithiadiaz-gly-csdap
1052:impy-24thioph-bala-psdap
1053:bim-me25thiaz-leu-psdap
1054:phhs-ithiadiaz-gly-ibsdap
1055:bhs-25methiaz-gly-betah35dc
1056:bhs-25thiaz-met-betameph
1057:tolhs-25methiaz-bala-betainyl
1058:phhs-25thiaz-gly-beta23meoph
1059:phhs-24thioph-gly-betafu2
1060:phhs-me24oxaz-gly-betadcph
1061:tolhs-25thiaz-bala-betah35dc
1062:bhs-24thioph-bala-psdapch
1063:bhs-me24thioph-gly-beta34meoph
1064:tolhs-me24thiaz-ala-betaph
1065:phhs-25methiaz-bala-betaibph
1066:ibhs-ithiadiaz-gly-betadcph
1067:phhs-24thiaz-gly-aspbzla
1068:tolhs-25methiaz-bala-betabdimo
1069:bhs-24thioph-ala-betadmph
1070:gua-42pym-gly-betahcbph
1071:ibhs-25oxaz-bala-betamesu

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-55-
1072:ibhs-25thiaz-bala-betahcbph
1073:bhs-24thiaz-gly-betabediox
1074:bhs-24thiaz-ala-betamesu
1075:gua-42pym-gly-betaet
1076:bhs-oxadiaz-bala-betathiome
1077:ibhs-25thiaz-gly-betahb
1078:tolhs-ithiadiaz-bala-betadcphtb
1079:bhs-24thiaz-bala-betaoxaz
1080:bhs-24thioph-gly-zdap
1081:bim-nme35pyr-bala-betapy
1082:ibhs-ithiadiaz-gly-beta23meoph
1083:bhs-25thiaz-ala-beta34meoph
1084:tolhs-me25thioph-bala-betadcph
1085:bhs-ithiadiaz-bafa-betaol
1086:phhs-24thiaz-gly-betacbph
1087:phhs-25methiaz-bala-betabenfu
1088:bim-nme35pyr-leu-betapy
1089:2py-35fur-leu-zdap
1090:ibhs-24thioph-gly-betabpy
1091:tolhs-25thiaz-bala-betathiome
1092:phhs-24thioph-bala-busu2be
1093:tolhs-oxadiaz-gly-betaphethio
1094:dhim-26py-ala-betathioph
1095:phhs-nme35pyr-gly-beta34dcph
1096:ibhs-25oxaz-bala-beta23meoph
1097:bhs-25thiaz-ala-zdap
1098:dhthi-24thiaz-bala-betadcph
1099:bhs-nme35pyr-bala-betaoxaz
1100:ibhs-25methiaz-bala-betapytb
1101:ibhs-nme35pyr-gly-betapytb
1102:tolhs-24thiaz-bala-betamesu
1103:bhs-24thioph-gly-betafu3
1104:tolhs-oxadiaz-gly-betabenfu
1105:tolhs-nme35pyr-gly-betafbph
1106:bim-ithiadiaz-bala-zdap
1107:gua-25thioph-gly-suabu
1108:bhs-oxadiaz-gly-betathiobe

CA 02371604 2001-10-24
WO 00/66618 PCTIEP00I03469
-56
1109:phhs-25oxaz-gly-betafluo
1110:2py-me25oxaz-leu-psdap
1111:ibhs-25oxaz-bala-betahni
1112:ibhs-oxadiaz-gly-betaol
1113:tolhs-25thiaz-gly-betaftrif
1114:tolhs-25oxaz-bala-betabdimo
1115:tolhs-25oxaz-gly-asppha
1116:bhs-me24thiaz-ala-betaph
1117:tolhs-24thiaz-gly-betafbph
1118:2py-oxad iaz-g ly-psdap
1119:bhs-25thiaz-bala-betahb
1120:bim-35fur-leu-psdap
1121:bhs-ithiadiaz-nmgiy-ibsdap
1122:bhs-24oxaz-ala-betameph
1123:bhs-nme35pyr-bala-betapyr
1124:bhs-nme35pyr-ala-betapy
1125:tolhs-24thioph-gly-betaftrif
1126:phhs-25oxaz-gly-betaphethioa
1127:tolhs-nme35pyr-gly-csdap
1128:2py-25fur-bala-zdap
1129:2py-24oxaz-leu-psdap
1130:tolhs-24thiaz-bala-zdapch
1131:phhs-oxadiaz-gly-betaoxope
1132:ibhs-24thiaz-bala-betapym
1133:thpym-24thiaz-gly-beta35dbph
1134:phhs-ithiadiaz-bala-betadmph
1135:phhs-me25thiaz-leu-betaph
1136:phhs-nme35pyr-bala-betadcphch
1137:2py-me24thiaz-bala-betaph
1138:phhs-me24thioph-ala-betapy
1139:ibhs-25thiaz-bala-csdap
1140:tolhs-oxadiaz-bala-betaamibe
1141:ibhs-nme35pyr-gly-betabenfu
1142:bhs-25thiaz-gly-betainyl
1143:bhs-25thiaz-gly-betahdcph
1144:phhs-25thiaz-gly-betacph
1145:phhs-oxadiaz-gly-betafph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-57-
1146:phhs-25oxaz-gly-betapym
1147:tolhs-24thiaz-bala-betacph
1148:2py-me24thioph-ala-betaph
1149:ibhs-24thiaz-bala-betaipro
1150:hyd-25thiaz-bala-betameph
1151:bim-52thiaz-ala-betapy
1152:bim-me25thiaz-ala-beta34meoph
1153:bhs-oxadiaz-bala-betabmph
1154:dhim-24thiaz-ala-psdap
1155:ibhs-24thioph-bala-zdapee
1156:gua-25thiaz-gly-betahbcph
1157:bhs-ithiadiaz-bala-betabthioph
1158:tolhs-24thiaz-bala-beta13bendi
1159:bim-me24oxaz-ala-beta34meoph
1160:bim-me25oxaz-gly-betapy
1161:2py-25methiaz-gly-aspibua
1162:bim-25thiaz-leu-betapy
1163:bhs-25thiaz-gly-betah35dc
1164:tolhs-25thiaz-bala-betafbph
1165:bhs-24thioph-bala-csdap
1166:dhim-25thiaz-gly-betahdcph
1167:bhs-25oxaz-nmgly-betacthioph
1168:tolhs-24thiaz-gly-betadcphtb
1169:2py-25methiaz-bala-psdap
1170:bim-ithiadiaz-gly-betadcph
1171:bim-25fur-gly-psdap
1172:tolhs-ithiadiaz-gly-psdapch
1173:bhs-53pyrazo-gly-betadcph
1174:ibhs-oxadiaz-bala-betahb
1175:bhs-nme35pyr-gly-betaanaphth
1176.phhs-25thiaz-bala-psdapch
1177:tolhs-oxadiaz-bala-betahmo
1178:tolhs-25methiaz-bala-betathio3
1179:bim-25oxaz-ala-psdap
1180:bim-42nmeim-gly-betapy
1181:ibhs-nme35pyr-bala-betah35dc
1182:tolhs-24thioph-gly-betabthioph

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-58-
1183: tolhs-25methiaz-bala-betadito
1184: thpym-25thiaz-bala-psdap
1185: bhs-25oxaz-gly-zdap
1186: bhs-25thiaz-phe-betameph
1187: bhs-25methiaz~ly-betathiobe
1188: bhs-nme35pyr-bala-betameph
1189: phhs-ithiadiaz-gly-betaoxope
1190: tolhs-24thiaz-gly-betabpy
1191: phhs-ithiadiaz-bala-psdap
1192:bgua-42nmeim-gly-betadcph
1193: dhim-24oxaz-gly-betamyl
1194: impy-25oxaz-gly-betampy
1195: bhs-25methiaz-bala-betadmoph
1196: gua-24thiaz-gly-betadito
1197:ibhs-ithiadiaz-gly-busu2be
1198: bhs-oxadiaz-bala-betadito
1199: ibhs-24thiaz-bala-betaphethioa
1200: ibhs-ithiadiaz-bala-betatrif
1201: bhs-24thioph-ala-psdap
1202:ibhs-nme35pyr-bala-betahdbph
1203: bhs-24thioph-bala-psdap
1204: 2py-25thiaz-gly-betatbuph
1205: ibhs-24thioph-bala-beta3quin
1206: ibhs-ithiadiaz-bala-betaoxaz
1207:bhs-me24oxaz-gly-zdap
1208: gua-24thiaz-gly-betah35dc
1209: ibhs-24thioph-gly-betatrif
1210: tolhs-25methiaz-gly-betambiph
1211: thpym-26py-gly-betadcph
1212:phhs-24thioph-bala-betahmph
1213: ibhs-25methiaz-bala-betadmph
1214: tolhs-24thioph-gly-betafphe
1215; tolhs-25oxaz-bala-betabnaphth
1216: bhs-24thioph-gly-betaoxope
1217:pahs-26py-gly-betapy
1218: 2py-24im-gly-betadcph
1219: tolhs-nme35pyr-bala-betapytb

CA 02371604 2001-10-24
W0 00166618 PCTIEP00I03469
-59
1220: phhs-nme35pyr-gly-betapyee
1221: bhs-25thiaz-bala-betabmph
1222: gua-42pym-gly-betadmoph
1223: ibhs-nme35pyr-bala-betathiome
1224: ibhs-25methiaz-gly-betainyl
1225: bhs-24thiaz-gly-betahcbph
1226: ibhs-24thiaz-bala-psdap
1227: bhs-triaz-ala-zdap
1228. dhim-24thiaz-ala-betameph
1229:ibhs-24thiaz-bala-betapych
1230: ibhs-25methiaz-gly-betaoxope
1231: tolhs-24thiaz-bala-betahbcph
1232: tolhs-24thioph-giy-betathio3
1233: tolhs-oxadiaz-gly-betapych
1234:tolhs-24thiaz-bala-betatbuph
1235: 2py-25oxaz-leu-betadcph
1236: ibhs-24thiaz-gly-betadito
1237: tolhs-25thiaz-bala-betacthioph
1238: phhs-24thiaz-bala-betaimid
1239:ibhs-25methiaz-gly-betabnaphth
1240: dhim-24oxaz-ala-betameph
1241: phhs-oxadiaz-gly-beta34meoph
1242: 2py-oxadiaz-bala-asppha
1243: phhs-nme35pyr-gly-aspibua
1244:ibhs-nme35pyr-gly-beta13bendi
1245: bhs-oxadiaz-gly-betahb
1246: tolhs-24thioph-gly-beta4bph
1247: ibhs-25oxaz-bala-betah35dc
1248: ibhs-25thiaz-gly-betaoxope
1249:thpym-25thioph-gly-betahcbph
1250: tolhs-25oxaz-bala-betahmofu
1251: bhs-42pym-ala-psdap
1252: bhs-24thiaz-nmgly-betaipro
1253: ibhs-nme35pyr-gly-betahmofu
1254:phhs-ithiadiaz-gly-betapym
1255: ibhs-24thioph-bala-betahbcph
1256: tolhs-oxadiaz-bala-betadcphch

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-60
1257:phhs-24thioph-bala-betabmph
1258:phhs-25oxaz-bala-betaftrif
1259:2py-thiadiaz-ala-betadcph
1260:phhs-me25thiaz-leu-psdap
1261:phhs-nme35pyr-gly-betapych
1262:bhs-oxadiaz-bala-betafu3
1263:2pmhs-42nmeim-bala-betameph
1264:ibhs-oxadiaz-bala-betabmph
1265:ibhs-25thiaz-bala-beta23meoph
1266:gua-25thiaz-giy-betaph
1267:bhs-24thiaz-ser-betapy
1268:bhs-24thiaz-met-betadcph
1269:bhs-ithiadiaz-gly-betacthioph
1270:bhs-42pym-gly-betainyl
1271:2py-triaz-bala-zdap
1272:2py-me24oxaz-ala-zdap
1273:phhs-24thioph-bala-betahc
1274:tolhs-24thioph-bala-psdapch
1275:phhs-oxadiaz-gly-betainyl
1276:bhs-25thiaz-nmgly-betamesu
1277:ibhs-24thioph-bala-beta34dcph
1278:phhs-nme35pyr-bala-betameph
1279:phhs-24thioph-bala-betaamibe
1280:2py-oxadiaz-leu-psdap
1281;bim-25thiaz-ala-betadcph
1282:bim-35thioph-gly-zdap
1283:bim-35py-gly-zdap
1284:ibhs-25oxaz-bala-betapyee
1285:tolhs-me24thiaz-bala-zdap
1286:tolhs-25thiaz-bala-betadito
1287:phhs-oxadiaz-gly-betadtrif
1288:bhs-24thioph-gly-betathiobe
1289:bhs-25thiaz-gly-betaphethioa
1290:tolhs-25oxaz-gly-betahc
1291:bhs-25oxaz-gly-betaimid
1292:tolhs-oxadiaz-bala-betaipr
1293:phhs-24thiaz-gly-betapyr

CA 02371604 2001-10-24
WO 00/66618 PCTIEPOOl03469
-61
1294:bhs-me25thioph-gly-betadcph
1295:phhs-nme35pyr-bala-betadmoph
1296:phhs-24thioph-bala-betabpy
1297:phhs-24thioph-bala-beta23meoph
1298:phhs-24thiaz-bala-zdapch
1299:bhs-42oxaz-bala-zdap
1300:ibhs-ithiadiaz-bala-betadcphee
1301;phhs-nme35pyr-bala-betambiph
1302:bim-42nmeim-bala-betacbph
1303:tolhs-25thiaz-bala-beta34dcph
1304:hs-25methiaz-bala-betapy
1305:dhim-4.2pym-gly-betapy
1306:bhs-42oxaz-leu-betapy
1307:bhs-24thiaz-nmgly-betadmph
1308:dhim-25thiaz-ala-psdap
1309:phhs-25oxaz-bala-betamethi
1310:phhs-me24thiaz-ala-betaph
1311:ibhs-24thioph-gly-betameph
1312:gua-24oxaz-gly-betaheph
1313:bhs-ithiadiaz-gly-betal3bendi
1314:bhs-ithiadiaz-bala-betahcbph
1315:bhs-nme35pyr-gly-betaheph
1316:bhs-25thiaz-1eu-psdap
1317:tolhs-25oxaz-bala-betadmoph
1318:bim-25thiophme-gly-zdap
1319:bhs-nme35pyr-nmgly-betabnaphth
1320:2py-24thioph-bala-betahni
1321:phhs-oxadiaz-bala-psdapch
1322:ibhs-25thiaz-bala-betabediox
1323:tolhs-25oxaz-gly-betafphe
1324:ibhs-25methiaz-bala-beta4bph
1325:tolhs-25thiaz-gly-betadbph
1326:dhim-26py-gly-zdap
1327:ibhs-24thioph-gly-betacthioph
1328:2py-ithiadiaz-gly-psdap
1329:tolhs-me25oxaz-ala-betaph
1330:ibhs-nme35pyr-gly-betamethioph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-62
1331:bhs-ithiadiaz-bala-betabpy
1332:bhs-oxadiaz-bala-betabph
1333:ibhs-oxadiaz-gly-betampy
1334:dhthi-26py-gly-betapy
1335:bhs-25thiaz-gly-betadmph
1336:bim-25methiaz-gly-betaomebendi
1337:tolhs-25thiaz-bala-betadhbfu
1338:bhs-oxadiaz-nmgly-beta34meoph
1339:bim-nme35pyr-bala-asppha
1340:2py-42nmeim-gly-betafphe
1341:bhs-35thioph-gly-psdap
1342:2py-42nmeim-bala-betaanaphth
1343:phhs-25thiaz-gly-psdapch
1344:bhs-25methiaz-bala-betabdimo
1345:tolhs-me24oxaz-gly-betaph
1346:ibhs-24thioph-bala-betadito
1347:bhs-24thioph-nmgly-betabnaphth
1348:bhs-oxadiaz-bala-betadcphtb
1349:bhs-26py-ala-psdap
1350:bhs-24thioph-nmgly-betamesu
1351:tolhs-oxadiaz-bala-betaimid
1352:bhs-ithiadiaz-nmgly-betadito
1353:phhs-25methiaz-bala-zdapee
1354:bhs-ithiadiaz-bala-betaphethioa
1355:impy-24thioph-gly-betambiph
1356:bhs-ithiadiaz-gly-betafu2
1357:bhs-ithiadiaz-nmgly-betathioph
1358:phhs-25oxaz-bala-suabu
1359:bhs-25methiaz-bala-betacbph
1360:phhs-me24oxaz-bala-betadcph
1361:dhim-25thiaz-gly-betadtrif
1362:bhs-24thioph-bala-betathiome
1363:phhs-25oxaz-gly-beta34dcph
1364:tolhs-me25oxaz-bala-betadcph
1365:ibhs-25thiaz-gly-betaamibe
1366:bhs-nme35pyr-nmgly-beta23meoph
1367:2py-24thiaz-gly-aspaba

CA 02371604 2001-10-24
WO 00166fi18 PCTIEP00103469
-63-
1368:gua-24thioph-bala-betadcph
1369:tolhs-24thioph-gly-betamethioph
1370:gua-24thiaz-gly-betaph
1371:2py-25methiaz-bala-aspibua
1372:ibhs-25oxaz-gly-zdaptb
1373:phhs-me25thiaz-leu-betadcph
1374:bhs-nme35pyr-bala-psdaptb
1375:bhs-25methiaz-gly-betahcbph
1376:ibhs-25methiaz-gly-betah35dc
1377:bhs-24thiaz-bala-aspaba
1378:tolhs-ithiadiaz-bala-beta13bendi
1379:bhs-ithiadiaz-bala-betaph
1380:tolhs-oxadiaz-gly-betaoxope
1381:2py-thiadiaz-gly-betapy
1382:phhs-24thiaz-bala-betaphethioa
1383:gua-24thiaz-gly-beta35dbph
1384:bim-26py-gly-betainyl
1385:pahs-25thiaz-bala-betameph
1386:bim-thiadiaz-ala-psdap
1387:bhs-me24thiaz-leu-beta34meoph
1388:phhs-25oxaz-gly-betambiph
1389:phhs-oxadiaz-gly-betaomebendi
1390:phhs-25oxaz-bala-betamethioph
1391:dhim-24thiaz-gly-betapy
1392:bim-24thioph-nmala-betadcph
1393:bhs-nme35pyr-gly-betampy
1394:2py-me24oxaz-ba la-betapy
1395:2py-25thioph-gly-zdap
1396:ibhs-24thioph-bala-betah35dc
1397:phhs-me25thioph-gly-betadcph
1398:bhs-24thioph-bala-betapym
1399:tolhs-24thioph-gly-aspbzla
1400:ibhs-25thiaz-bala-betapyee
1401:tolhs-nme35pyr-gly-betapyee
1402:bhs-25oxaz-gly-betahdcph
1403:bhs-25oxaz-gly-beta4bph
1404:ibhs-24thiaz-bala-beta4bph

CA 02371604 2001-10-24
WO 00166fi18 PCTlEP001034fi9
-64-
1405:bim-ithiadiaz-bala-betapy
1406:ibhs-nme35pyr-bala-betabdimo
1407:2py-25thiaz-gly-aspibua
1408:bhs-25oxaz-ala-betabpy
1409:bhs-oxadiaz-gly-betahbcph
1410:bim-me25thioph-leu-betaph
1411:bhs-24thiaz-bala-betadito
1412:dhim-24oxaz-gly-betadcph
1413:tolhs-ithiadiaz-gly-betahcbph
1414:bhs-nme35pyr-leu-betapy
1415:tolhs-nme35pyr-bala-betaol
1416:ibhs-oxadiaz-gly-betapych
1417:tolhs-nme35pyr-gly-betacthioph
1418:tolhs-nme35pyr-bala-aspbzla
1419:2py-me24thioph-gly-beta34meoph
1420:dhpyrr-24thiaz-gly-betadcph
1421:bhs-24thiaz-gly-betaet
1422:bim-24thiaz-nmala-betadcph
1423:ibhs-nme35pyr-gly-betambiph
1424:tolhs-ithiadiaz-gly-ibsdap
1425:tolhs-25oxaz-gly-betacthioph
1426:tolhs-24thioph-gly-betadhbfu
1427:bhs-me25thiaz-ala-betaph
1428:phhs-25thiaz-bala-betameph
1429:bhs-24thiaz-ala-beta34dcph
1430:ibhs-nme35pyr-bala-betapyr
1431:2py-me24thioph-leu-betapy
1432:bhs-24thiaz-bala-betafu2
1433:bhs-ithiadiaz-bala-betaamibe
1434:bhs-25methiaz-ala-betadmoph
1435:bim-me24thiaz-gly-zdap
1436:bim-25methiaz-bala-csdap
1437:2py-me25oxaz-ala-beta34meoph
1438;phhs-oxadiaz-gly-ibsdap
1439:phhs-25thiaz-bala-betabph
1440:bhs-25methiaz-ala-beta34dcph
1441:tolhs-oxadiaz-bala-betapyee

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-65-
1442:ibhs-oxadiaz-bala-betaanaphth
1443:tolhs-25oxaz-bala-betathiobe
1444:2pmhs-24thiaz-bala-beta4bph
1445:ibhs-ithiadiaz-gly-ibsdap
1446:phhs-24thioph-bala-aspaba
1447:tolhs-24thiaz-bala-betaamibe
1448:bhs-25methiaz-gly-betaanaphth
1449:bhs-24thioph-gly-betaph
1450:bhs-oxadiaz-bala-betahb
1451:bhs-52thiaz-gly-betapy
1452:ibhs-oxadiaz-bala-betafluo
1453:phhs-nrne35pyr-bala-betadtrif
1454:phhs-25oxaz-bala-betapyr
1455:bhs-25methiaz-bala-betaipr
1456:ibhs-24thiaz-gly-beta35dbph
1457:ibhs-25thiaz-gly-psdapch
1458:bhs-24thiaz-bala-betatbuph
1459:tolhs-ithiadiaz-bala-betadmoph
1460:ibhs-25thiaz-gly-betaftrif
1461:bhs-25methiaz-ala-betafphe
1462:sabhs-42pym-gly-betapy
1463:phhs-me25thiaz-bala-zdap
1464:phhs-24thiaz-gly-betaibph
1465:2py-25methiaz-gly-betacthioph
1466:dhim-25thioph-gly-betapy
1467:bim-me24thiaz-bala-psdap
1468:ibhs-24thioph-gly-betabnaphth
1469:tolhs-25methiaz-bala-betaoxope
1470:sabhs-25oxaz-bala-betameph
1471:tolhs-25methiaz-gly-beta34dcph
1472:ibhs-oxadiaz-bala-betathiome
1473:dhim-42pym-gly-betahdcph
1474:2py-25thiaz-leu-betapy
1475:ibhs-25thiaz-gly-betah35dc
1476:bhs-25oxaz-bala-betathiobe
1477:bhs-oxadiaz-nmgly-betamesu
1478:bhs-oxadiaz-bala-betaol

CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-66-
1479:phhs-oxadiaz-gly-aspbzla
1480:hs-25thiaz-gly-betapy
1481:tolhs-ithiadiaz-bala-betaomebendi
1482:tolhs-25methiaz-bala-beta4bph
1483:phhs-ithiadiaz-bala-csdap
1484:bim-25py-gly-zdap
1485:ibhs-24thioph-gly-betafbph
1486:impy-25methiaz-gly-betambiph
1487:2pmhs-25thiaz-bala-betamethioph
1488:tolhs-24thioph-bala-betafluo
1489:ibhs-ithiadiaz-gly-aspaba
1490;phhs-25methiaz-bala-betacph
1491:bhs-nme35pyr-gly-betatos
1492:dimethpym-25thiaz-gly-betadcph
1493:ibhs-oxadiaz-bala-betaimid
1494:tolhs-24thioph-bala-betaoxope
1495:bhs-nme35pyr-bala-betamethioph
1496:2py-me24thiaz-leu-betaph
1497:tolhs-nme35pyr-bala-betahni
1498:phhs~xadiaz-gly-betacthioph
1499:bhs-25thiaz-gly-busu2be
1500:ibhs-oxadiaz-bala-betaipro
1501:tolhs-25thiaz-bala-betadmoph
1502:bhs-25methiaz-ala-betainyl
1503:bhs-25oxaz-bala-betahcbph
1504:ibhs-ithiadiaz-gly-betacthioph
1505:tolhs-nme35pyr-bala-betaomebendi
1506:phhs-24thioph-bala-betaipr
1507;tolhs-25methiaz-gly-betaoxaz
1508:tolhs-nme35pyr-bala-betaamibe
1509:bhs-25thiaz-bala-betaheph
1510:ibhs-24thioph-gly-asppha
1511:phhs-oxadiaz-bala-betadmoph
1512:2py-25thiaz-ala-betameph
1513:bhs-thiadiaz-ala-zdap
1514:bhs-24thiaz-bala-betafph
1515:2pmhs-25thiaz-bala-betabmph

CA 02371604 2001-10-24
WO 00166618 PCTlEPOOI03469
-67-
1516:bhs-24thioph-bala-betafu2
1517:bim-me25thioph-bala-zdap
1518:bhs-25methiaz-gly-aspibua
1519:bhs-nme35pyr-nmgly-beta34dcph
1520:gua-24thiaz-gly-betafu2
1521:phhs-oxadiaz-gly-betambiph
1522:bhs-24thioph-bala-aspaba
1523:phhs-24thiaz-gly-beta35dbph
1524:ibhs-24thioph-gly-betaipro
1525:bhs-ithiadiaz-bala-psdapch
1526:bhs-25oxaz-gly-betamethioph
1527:bhs-25thiaz-ala-beta34dcph
1528:bhs-ithiadiaz-bala-betaipro
1529:bhs-25oxaz-gly-betah35dc
1530:gua-25thioph-gly-betah35dc
1531:bhs-25oxaz-gly-betabph
1532:bhs-oxadiaz-bala-betaphethio
1533:impy-24thiaz-bala-psdap
1534:bhs-25methiaz-gly-betaol
1535:phhs-25oxaz-bala-betapytb
1536:tolhs-25oxaz-bala-zdaptb
1537:tolhs-nme35pyr-bala-betadcphee
1538:bgua-25thioph-gly-betameph
1539:bhs-oxadiaz-gly-betathio3
1540:ibhs-25thiaz-gly-betahc
1541:gua-24thiaz-gly-betathioph
1542:2py-53pyrazo-bala-betapy
1543:phhs-ithiadiaz-gly-beta34dcph
1544:dhim-25thioph-ala-betadcph
1545:phhs-25thiaz-gly-betapy
1546:ibhs-25thiaz-bala-betah35dc
1547:phhs-25methiaz-gly-psdap
1548:bhs-oxadiaz-gly-betafluo
1549:impy-25thiaz-gly-betacbph
1550:2py-24im-bala-zdap
1551:tolhs-oxadiaz-bala-betahb
1552:phhs-25oxaz-bala-betaoxope

CA 02371604 2001-10-24
WO OOI66618 PCTlEP00103469
-68
1553:tolhs-25thiaz-gly-betaipr
1554:ibhs-oxadiaz-bala-csdap
1555:ibhs-24thiaz-gly-betampy
1556:bim-thiadiaz-gly-betadcph
1557:2py-me24thioph-bala-betadcph
1558:bhs-ithiadiaz-nmgly-betadhbfu
1559:phhs-25oxaz-bala-betathioph
1560:ibhs-25oxaz-bala-betaol
1561:bhs-nme35pyr-gly-betaoxope
101562:phhs-ithiadiaz-bala-betathiobe
1563:2py-25methiaz-leu-zdap
1564:tolhs-25thiaz-gly-betafu2
1565:phhs-24thioph-bala-betahni
1566;ibhs-nme35pyr-gly-betatbuph
151567:ibhs-ithiadiaz-gly-betapbiph
1568:tolhs-oxadiaz-gly-betatos
1569:bim-triaz-bala-betapy
1570:tolhs-25oxaz-bala-betafphe
1571:bhs-ithiadiaz-nmgly-betathio3
201572:2py-me25thioph-gly-zdap
1573:tolhs-25oxaz-gly-csdap
1574:2py-thiadiaz-gly-psdap
1575:bhs-52thiaz-gly-betainyl
1576:phhs-ithiadiaz-gly-betahmo
251577:ibhs-25thiaz-gly-betathiome
1578:2py-oxadiaz-bala-betapy
1579:2pmhs-24thiaz-bala-betathioph
1580:bim-25thiaz-bala-betahc
1581;bim-triaz-leu-psdap
301582:phhs-25methiaz-bala-aspibua
1583:bhs-me24thioph-bala-beta34meoph
1584:phhs-25oxaz-gly-betadcphtb
1585:tolhs-ithiadiaz-gly-beta4bph
1586:ibhs-25oxaz-bala-betamethioph
351587:phhs-ithiadiaz-gly-betah35dc
1588;bhs-25methiaz-gly-betahdbph
1589:gua-25thiaz-gly-betahdbph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-69-
1590:4pmhs-24thiaz-bala-betameph
1591:bhs-ithiadiaz-gly-betainyl
1592:tolhs-25oxaz-bala-betah35dc
1593:2py-25fur-bala-psdap
1594:nmhs-24thiaz-gly-psdap
1595:phhs-25methiaz-bala-betadcphee
1596:ibhs-25methiaz-bala-betabph
1597:ibhs-oxadiaz-bala-betabph
1598:ibhs-ithiadiaz-bala-betahbcph
1599:2py-triaz-ala-zdap
1600:bhs-nme35pyr-nmgly-beta3quin
1601:dhim-25thioph-ala-zdap
1602:bhs-me24oxaz-leu-beta34meoph
1603:phhs-25methiaz-gly-aspaba
1604:bhs-nme35pyr-bala-betadtrif
1605:tolhs-24thioph-bala-betadtrif
1606:bhs-25methiaz-bala-betahb
1607:2py-24thiaz-ala-betainyl
1608:bhs-25thiaz-gly-betaph
1609:tolhs-oxadiaz-bala-betabediox
1610:bhs-oxadiaz-bala-betaoxope
1611:bhs-25thiaz-nmgly-betaanaphth
1612:phhs-24thioph-gly-betadmph
1613:phhs-25methiaz-gly-betainyl
1614:gua-24thiaz-gly-betadcph
1615:bhs-24thioph-bala-betadcphee
1616:phhs-ithiadiaz-gly-betabph
1617:bhs-thiadiaz-ala-betapy
1618:bim-me25oxaz-leu-psdap
1619:2py-me24thioph-bala-betaph
1620:tolhs-nme35pyr-bala-betabediox
1621:bhs-25methiaz-ala-beta34meoph
1622:tolhs-ithiadiaz-gly-betadmoph
1623:bhs-24thiaz-nmala-betapy
1624:2py-triaz-leu-betadcph
1625:ibhs-24thioph-bala-betaibph
1626:phhs-me25oxaz-ala-betaph

CA 02371604 2001-10-24
WO OOI66618 PCTIEP00I03469
-70
1627:gua-24oxaz-gly-betaph
1628:phhs-ithiadiaz-gly-betapych
1629:bhs-me24oxaz-leu-zdap
1630:ibhs-25thiaz-bala-betamethi
1631:bim-42oxaz-leu-psdap
1632:bhs-25thiaz-hphe-betameph
1633:bhs-nme35pyr-nmgly-betabpy
1634:2pmhs-25thiaz-bala-beta13bendi
1635:ibhs-ithiadiaz-gly-zdapch
1636:tolhs-oxadiaz~ly-psdapee
1637:bhs-25oxaz-ala-betainyl
1638:tolhs-25thiaz-bala-suabu
1639:bim-24thiaz-leu-betadcph
1640:bhs-24thioph-gly-beta34dcph
1641:tolhs-oxadiaz-gly-aspaba
1642:phhs-25thiaz-gly-betathiome
1643:phhs-24thioph-bala-psdaptb
1644:phhs-nme35pyr-bala-betabediox
1645:tolhs-oxadiaz-gly-betahcbph
1646:bhs-ithiadiaz-bala-betaomebendi
1647:phhs-24thioph-bala-betahph
1648:2py-me25thioph-ala-psdap
1649:2py-24thiaz-leu-betapy
1650:2py-25oxaz-gly-aspibua
1651:sabhs-24thiaz-gly-betapy
1652:phhs-25oxaz-gly-betahbcph
1653:tolhs-25methiaz-bala-betabph
1654:bhs-ithiadiaz-bala-aspibua
1655:dhim-26py-gly-betaoxaz
1656:ibhs-oxadiaz-gly-beta4bph
1657:bhs-24thiaz-nmgly-beta3quin
1658:phhs-25methiaz-gly-betabph
1659:tolhs-25methiaz-gly-betathiobe
1660:bhs-25thiaz-bala-zdapee
1661:bim-24thiaz-bala-zdap
1662:2pmhs-42nmeim-ser-psdap
1663:phhs-24thiaz-gly-betathio3

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-71
1664:bhs-24thioph-nmgly-beta13bendi
1665:phhs-25methiaz-gly-betaheph
1666:tolhs-25thiaz-gly-betaet
1667:tolhs-me24thioph-ala-betadcph
1668:ibhs-25oxaz-bala-betaipr
1669:phhs-me25thioph-ala-zdap
1670:ibhs-25thiaz-bala-betambiph
1671:tolhs-me25thioph-ala-beta34meoph
1672:ibhs-25thiaz-gly-betaphethio
1673:phhs-24thiaz-bala-betaomebendi
1674:ibhs-24thiaz-gly-beta34meoph
1675:bim-35fu~-bala-betapy
1676:tolhs-25thiaz-gly-zdapee
1677:ibhs-25oxaz-gly-betatrif
1678:phhs-oxadiaz-gly-betamethioph
1679:2py-thiadiaz-bafa-zdap
1680:bhs-24thioph-bala-zdapch
1681:bhs-25methiaz-bala-betafu2
1682:ibhs-oxadiaz-gly-psdap
1683:bhs-oxadiaz-gly-betapyee
1684:bhs-me24thioph-gly-zdap
1685:bim-me25oxaz-ala-zdap
1686:bhs-25methiaz-gly-betaomebendi
1687:tolhs-25thiaz-bala-betahb
1688:2py-24thioph-bala-beta34dcph
1689:ibhs-oxadiaz-bala-betapych
1690:ibhs-24thioph-gly-betafu2
1691:bhs-25oxaz-ala-beta3quin
1692:bhs-24thioph-bala-betabediox
1693:phhs-nme35pyr-gly-betapy
1694:ibhs-ithiadiaz-gly-betamesu
1695:bhs-25methiaz-gly-betabediox
1696:phhs-25thiaz-gly-betafu2
1697:2py-24thiaz-bala-betaheph
1698:phhs-oxadiaz-gly-asppha
1699:ibhs-ithiadiaz-bala-psdap
1700:thpym-25methiaz-bala-psdap

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-72-
1701:tolhs-25oxaz-bala-betabenfu
1702:ibhs-ithiadiaz-gly-betathio3
1703:bhs-25methiaz-gly-betampy
1704:bim-52thiaz-gly-betameph
1705:tolhs-nme35pyr-gly-beta23meoph
1706:bhs-ithiadiaz-bala-betaftrif
1707:bhs-25oxaz-gly-betadmoph
1708:phhs-24thiaz-gly-betainyl
1709:ibhs-25thiaz-gly-betaanaphth
1710:phhs-ithiadiaz-bala-betaphethio
1711:phhs-25thiaz-bala-betahdcph
1712:4pmhs-25oxaz-gly-betapy
1713:bhs-53pyrazo-ala-betapy
1714:phhs-nme35pyr-bala-betathioph
1715:bhs-nme35pyr-nmgly-betamesu
1716:phhs-25oxaz~ly-betampy
1717:2py-25oxaz-ba la-betapheth
ioa
1718:bhs-25methiaz-bala-betafu3
1719:phhs-me24oxaz-leu-betadcph
1720:bhs-25thiaz-ala-ibsdap
1721:bhs-ithiadiaz-gly-betabmph
1722:bhs-ithiadiaz-bala-betadmoph
1723:phhs-25thiaz-gly-betatbuph
1724:2py-42pym-ala-psdap
1725:ibhs-nme35pyr-gly-betaoxaz
1726:phhs-24thioph-bala-betafu3
1727:phhs-25oxaz-bala-betapbiph
1728:2py-me25oxaz-ala-betapy
1729:phhs-me24thiaz-gly-betaph
1730:bhs-25methiaz-nmgly-betaipro
1731:phhs-me24thiaz-leu-psdap
1732:gua-42pym-gly-betaphethio
1733:bhs-24thioph-gly-betaoxaz
1734:bhs-oxadiaz-bala-betahc
1735:ibhs-nme35pyr-gly-betainyl
1736:tolhs-nme35pyr-bala-psdaptb
1737:bhs-oxadiaz-bala-betadmph

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-73
1738:phhs-ithiadiaz-gly-betafbph
1739:phhs-25thiaz-gly-betahcbph
1740:tolhs-25oxaz-bala-betaibph
1741:tolhs-25oxaz-gly-betapych
1742:bhs-24thiaz-nmgly-betabnaphth
1743:phhs-25methiaz-gly-zdap
1744:2py-42nmeim-gly-betaipro
1745:bhs-24thioph-bala-betafph
1746:ibhs-24thioph-bala-betambiph
1747:2pmhs-42nmeim-gly-betahdcph
1748:2py-24thiaz-gly-zdap
1749:phhs-oxadiaz-bala-betamethi
1750:bhs-me25thiaz-bala-betaph
1751:bhs-triaz-ala-betadcph
1752:bhs-25methiaz-bala-betahmofu
1753:bhs-25thiaz-ala-betafphe
1754:phhs-oxadiaz-bala-betafluo
1755:phhs-24thiaz-bala-betabenfu
1756:2py-24thiaz-bala-aspbzla
1757:bhs-24thiaz-ala-psdap
1758:phhs-oxadiaz-gly-betapyee
1759:tolhs-25thiaz-bala-betaph
1760:ibhs-24thioph-bala-betaheph
1761:tolhs-24thioph-bala-zdaptb
1762:tolhs-24thiaz-gly-zdapee
1763:ibhs-ithiadiaz-bala-betaomebendi
1764:phhs-ithiadiaz-bala-betamethioph
1765:phhs-nme35pyr-bala-betathiobe
1766:phhs-25thiaz-bala-betafphe
1767:ibhs-25thiaz-bala-beta34dcph
1768:phhs-24thiaz-gly-psdaptb
1769:tolhs-24thioph-gly-betatos
1770:gua-26py-gly-betamethi
1771:bhs-oxadiaz-gly-betahmofu
1772:impy-4.2nmeim-gly-betahph
1773:bhs-24thiaz-bala-betadcphtb
1774:tolhs-ithiadiaz-gly-busu2be

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-74
1775:bim-me24oxaz-bala-beta34meoph
1776.tolhs-25methiaz-gly-betafu3
1777:tolhs-25oxaz-bala-aspbzla
1778:bhs-oxadiaz-ala-betacph
1779:phhs-ithiadiaz-bala-aspbzla
1780:ibhs-25thiaz-bala-betaph
1781:tolhs-oxadiaz-bala-csdap
1782:ibhs-oxadiaz-gly-betadtrif
1783:ibhs-25thiaz-gly-betadito
1784:tolhs-25oxaz-bala-suabu
1785:bhs-ithiadiaz-bala-zdap
1786:bhs-25thioph-gly-psdap
1787:2py-24im-ala-zdap
1788:2pmhs-25methiaz-gly-betaph
1789:phhs-25oxaz-gly-psdap
1790:bhs-24thioph-bala-betabenfu
1791:bim-me25oxaz-gly-betadcph
1792:bhs-oxadiaz-bala-betahmph
1793:ibhs-ithiadiaz-bala-betafph
1794:ibhs-25oxaz-bala-betacph
1795:ibhs-25methiaz-gly-betaipro
1796:ibhs-24thiaz-gly-betabph
1797:2py-triaz-leu-betapy
1798:tolhs-nme35pyr-gly-zdapch
1799:bhs-thiadiaz-leu-betadcph
1800:tolhs-ithiadiaz-bala-beta34dcph
1801:phhs-25oxaz-bala-betampy
1802:tolhs-nme35pyr-gly-betabediox
1803:phhs-24thiaz-gly-betabenfu
1804:ibhs-24thioph-gly-betaanaphth
1805:ibhs-24thiaz-bala-betabthioph
1806:bhs-24thiaz-gly-betameph
1807:bhs-24thioph-bala-betaph
1808:ur-25oxaz-bala-zdap
1809:phhs-25thiaz-gly-betadcph
1810:ibhs-24thiaz-gly-betaphethio
1811:agua-24thioph-gly-psdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-75
1812: tolhs-24thiaz-bala-betadmoph
1813: phhs-nme35pyr-gly-betaheph
1814: bhs-ithiadiaz-gly-aspbzla
1815: cima-25methiaz-bala-psdap
1816: bim-25thiaz-bala-aspaba
1817: phhs-oxadiaz-bala-betahcbph
1818: phhs-me24thiaz-ala-betadcph
1819: bim-25oxaz-gly-betafph
1820: bhs-25methiaz-gly-betabenfu
1821:gua-42pym-gly-betabph
1822: bim-24thioph-bala-asppha
1823: ibhs-oxadiaz-bala-betamethi
1824: tolhs-24thiaz-bala-betabediox
1825: tolhs-25oxaz-bala-psdap
1826:ibhs-25thiaz-bala-beta35dbph
1827: ibhs-25oxaz-gly-betamesu
1828: ibhs-24thioph-gly-betambiph
1829: bhs-25oxaz-gly-betahcbph
1830: ibhs-24thioph-gly-betahc
1831:2py-25methiaz-gly-asppha
1832: phhs-oxadiaz-gly-betacbph
1833: ibhs-ithiadiaz-bala-betaipro
1834: bhs-25thiaz-ala-betacthioph
1835: phhs-25thiaz-gly-aspibua
1836:ibhs-25methiaz-bala-betamesu
1837: bim-42nmeim-bala-betabediox
1838: tolhs-me25thioph-gly-betadcph
1839: ibhs-25methiaz-bala-betafbph
1840: phhs-25oxaz-gly-beta35dbph
1841:phhs-24thioph-bala-betaet
1842: ibhs-25oxaz-gly-betadcphee
1843: phhs-25oxaz-gly-betadtrif
1844: hs-42nmeim-bala-zdap
1845: bim-25methiaz-gly-betaibph
1846:bim-thiadiaz-ala-betapy
1847: 2py-me24im-ala-betapy
1848: bhs-24thiaz-gly-betamethioph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-76-
1849:tolhs-24thiaz-gly-beta23meoph
1850:tolhs-nme35pyr-bala-zdaptb
1851:ibhs-nme35pyr-gly-betah35dc
1852:bhs-25thiaz-gly-betahph
1853:bhs-25thiaz-bala-betatbuph
1854:ur-24thioph-gly-betadcph
1855:tolhs-me25thiaz-gly-psdap
1856:ibhs-24thiaz-gly-betafu2
1857:bhs-ithiadiaz-gly-betathiobe
1858:bim-25fur-bala-betapy
1859:phhs-25thiaz-gly-betahmph
1860:tolhs-nme35pyr-bala-betadbph
1861:ibhs-oxadiaz-bala-betamesu
1862:ibhs-25oxaz-bala-betabediox
1863:tolhs-oxadiaz-bala-betabnaphth
1864:bhs-oxadiaz-bala-zdapee
1865:ibhs-24thiaz-bala-betafph
1866:tolhs-25methiaz-bala-betaibph
1867:bhs-24thioph-gly-betatrif
1868:3pmhs-42nmeim-bala-zdap
1869:phhs-nme35pyr-gly-betathioph
1870:tolhs-nme35pyr-bala-busu2be
1871:bhs-24thiaz-gly-betaoxope
1872:tolhs-24thiaz-gly-betatrif
1873:bhs-25methiaz-gly-betahmo
1874:tolhs-oxadiaz-gly-betahph
1875:phhs-ithiadiaz-gly-zdaptb
1876:bim-42nmeim-bala-betahmofu
1877:2py-thiadiaz-gly-zdap
1878:bhs-ithiadiaz-gly-betahmo
1879:bim-25thiaz-gly-aspibua
1880:bhs-nme35pyr-gly-betapy
1881:bhs-ithiadiaz-ala-betapy
1882:ibhs-nme35pyr-bala-betafphe
1883:bhs-53pyrazo-bala-betadcph
1884:ibhs-25methiaz-gly-betahcbph
1885:tolhs-25methiaz-gly-betaphethio

CA 02371604 2001-10-24
WO 00166618 PCTI~P00103469
-77
1886:bhs-24thiaz-bala-beta23meoph
1887:ibhs-nme35pyr-gly-zdap
1888:bhs-25thiaz-gly-betadcphtb
1889:gua-26py-gly-betacbph
1890:2py-25th iaz-g ly-betath
io3
1891:tolhs-24thioph-bala-betapyee
1892:bhs-oxadiaz-gly-betaoxaz
1893:ibhs-25thiaz-bala-betahdbph
1894:ibhs-ithiadiaz-bala-betaheph
1895:ibhs-24thiaz-gly-betahmofu
1896:tolhs-24thioph-bala-betaoxaz
1897:phhs-25methiaz-gly-betapbiph
1898:tolhs-24thiaz-gly-betamethi
1899:tolhs-24thiaz-bala-betamethioph
1900:bhs-ithiadiaz-bala-betapyee
1901:bhs-25thiaz-bala-zdaptb
1902:ibhs-nme35pyr-bala-beta34meoph
1903:tolhs-me25thioph-ala-zdap
1904:ibhs-25methiaz-gly-betaamibe
1905:phhs-25oxaz-bala-betabdimo
1906:2py-triaz-gly-betapy
1907:ibhs-25oxaz-bala-betadcphch
1908:bhs-oxadiaz-nmgly-betadmph
1909:bhs-24thiaz-bala-beta35dbph
1910:tolhs-24thioph-gly-betapy
1911:gua-26py-gly-betacthioph
1912:bhs-25oxaz-bala-betapy
1913:dhpyrr-25thiaz-gly-betapy
1914:tolhs-24thioph-bala-betapym
1915:ibhs-24thioph-bala-betapbiph
1916:gua-26py-gly-betaipro
1917:bim-oxadiaz-bala-aspibua
1918:tolhs-nme35pyr-bala-betadtrif
1919:tolhs-25thiaz-gly-betafluo
1920:phhs-oxadiaz-bala-beta23meoph
1921:tolhs-25oxaz-bala-beta34dcph
1922:2py-me24oxaz-ala-betapy

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-78
1923:tolhs-25methiaz-gly-betapym
1924:phhs-nme35pyr-gly-betahdcph
1925:tolhs-oxadiaz-gly-betafbph
1926:tolhs-25methiaz-bala-csdap
1927:bhs-24im-gly-psdap
1928:2py-me25oxaz-bala-beta34meoph
1929:ibhs-25oxaz-gly-betahdbph
1930:ibhs-oxadiaz-bala-betahcbph
1931:phhs-24thioph-bala-csdap
1932:tolhs-24thiaz-gly-betameph
1933:bhs-24thioph-gly-betacbph
1934:ibhs-24thiaz-gly-psdapee
1935:phhs-24thiaz-gly-betafluo
1936:gua-42pym-gly-betacthioph
1937:bhs-25thiaz-bala-betadhbfu
1938:bhs-oxadiaz-bala-betadhbfu
1939:phhs-25methiaz-gly-busu2be
1940:phhs-24thiaz-gly-psdap
1941:ibhs-24thioph-bala-betathiobe
1942;phhs-ithiadiaz-gly-betatbuph
1943:tolhs-25methiaz-bala-betahmofu
1944:sabhs-24thioph-gly-psdap
1945;ibhs-25oxaz-gly-betaoxope
1946:tolhs-25thiaz-gly-beta34dcph
1947:phhs-nme35pyr-gly-betabph
1948:phhs-25thiaz-gly-betatrif
1949:bhs-ithiadiaz-ala-betadito
1950:bim-25thiaz-ala-betameph
1951:2py-35fur-gly-betadcph
1952:ibhs-25methiaz-gly-betabdimo
1953:cima-24thioph-bala-psdap
1954:phhs-24thioph-gly-betafph
1955:ibhs-ithiadiaz-bala-betafphe
1956:bim-24im-leu-betapy
1957:bhs-25thioph-gly-betacph
1958:impy-24thiaz-bala-betainyl
1959:bim-25methiaz-bala-asppha

CA 02371604 2001-10-24
WO 00166618 PCTlEP00l03469
-79-
1960:bhs-24thioph-bala-betadcphtb
1961:ibhs-oxadiaz-bala-psdaptb
1962:2py-me24thioph-gly-psdap
1963:2pmhs-24thiaz-bala-betamethioph
1964:ibhs-25methiaz-bala-betampy
1965:bhs-24thiophme-gly-betameph
1966:bhs-ithiadiaz-gly-betatrif
1967:dhim-26py-ala-betatbuph
1968:thpym-25thiaz-gly-betadcph
1969:2py-thiadiaz-ala-betapy
1970:~2py-25methiaz-bala-betaoxope
1971:tolhs-25methiaz-gly-ibsdap
1972:ibhs-ithiadiaz-gly-betaoxaz
1973:phhs-25thiaz-bala-asppha
1974:2py-42nmeim-gly-betampy
1975:2py-26py-ala-betapy
1976:phhs-24thiaz-gly-betadcphtb
1977:3pmhs-24thioph-bala-betapy
1978:2py-25thiaz-bala-aspbzla
1979:gua-42pym-gly-betahmo
1980:gua-26py-gly-betaamibe
1981:tolhs-25methiaz-gly-zdapee
1982:ibhs-25oxaz-gly-psdapch
1983:bhs-25thiaz-nmgly-betadmph
1984:bhs-nme35pyr-bala-betadmoph
1985:agua-25thiaz-gly-betadcph
1986:phhs-25methiaz-gly-betameph
1987:bhs-24thiaz-gly-beta35dbph
1988:ibhs-ithiadiaz-gly-betafphe
1989:bim-25oxaz-leu-betapy
1990:phhs-ithiadiaz-bala-betahmph
1991:2py-24thioph-bala-betaet
1992:2py-me24thiaz-gly-betaph
1993:2py-24im-ala-betadcph
1994:bhs-25thiaz-gly-betadmoph
1995:phhs-ithiadiaz-bala-betaet
1996:ibhs-25thiaz-bala-betaphethio

CA 02371604 2001-10-24
W~ 00166618 PCTIEP00103469
-80
1997:phhs-oxadiaz-bala-betahbcph
1998:ibhs-25methiaz-bala-betafphe
1999:ibhs-25thiaz-gly-suabu
2000:bim-24thiaz-ala-betameph
2001:phhs-me25thiaz-bala-betaph
2002:ibhs-25thiaz-gly-betapyr
2003:bhs-me25thioph-bala-betaph
2004:bhs-25oxaz-bala-aspaba
2005:2pmhs-25thiaz-bala-betathioph
2006:tolhs-oxadiaz-bala-psdap
2007:bhs-nme35pyr-gly-betaoxaz
2008:tolhs-25thiaz-gly-beta23meoph
2009:phhs-25methiaz-gly-betaamibe
2010:gua-25thioph-gly-betapy
2011:2py-nme35pyr-gly-psdap
2012:ibhs-ithiadiaz-gly-betahdbph
2013:2py-25oxaz-gly-betacbph
2014:bim-me24thioph-leu-zdap
2015:bhs-25thiaz-ala-beta13bendi
2016:phhs-24thioph-gly-betatrif
2017:2py-ith iad iaz-gly-betapy
2018:phhs-nme35pyr-gly-betapytb
2019:ibhs-ithiadiaz-gly-betaanaphth
2020:bhs-nme35pyr-ala-betaanaphth
2021:tolhs-nme35pyr-gly-betapych
2022:2py-me25thioph-bala-psdap
2023:ibhs-24thiaz-gly-betaet
2024.tolhs-24thioph-gly-beta3quin
2025:tolhs-24thiaz-bala-betaoxope
2026:ibhs-25methiaz-gly-beta34meoph
2027.ibhs-25oxaz-bala-betambiph
2028:phhs-25oxaz-gly-betafbph
2029:tolhs-24thiaz-gly-betathio3
2030:phhs-ithiadiaz-gly-betaipro
2031:phhs-25oxaz-gly-betacthioph
2032:bhs-25thiaz-bala-betaibph
2033:impy-24thioph-nmgly-psdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-81
2034:bhs-24im-gly-zdap
2035:bhs-thiadiaz-leu-betapy
2036:gua-25thiophme-gly-betapy
2037:bhs-24thiaz-gly-betafluo
2038:toihs-oxadiaz-bala-betathioph
2039:bhs-24im-ala-betapy
2040:bhs-24thiaz-bala-betabph
2041:bim-25oxaz-bala-betathioph
2042:bhs-nme35pyr-gly-betaamibe
2043:phhs-25oxaz-gly-beta23meoph
2044:ibhs-ithiadiaz-gly-betabdimo
2045:phhs-25methiaz-gly-betaipro
2046:phhs-24thiaz-gly-beta34meoph
2047:phhs-25thiaz-gly-betafluo
2048:bhs-25methiaz-bala-betaanaphth
2049:tolhs-25thiaz-bala-psdapee
2050:tolhs-24thiaz-gly-betafphe
2051:bhs-24thioph-gly-betafluo
2052:phhs-nme35pyr-gly-betahni
2053:2py-me24thioph-bala-betapy
2054:ibhs-25methiaz-gly-betafbph
2055:2py-nme35pyr-bala-aspaba
2056:bhs-24thiaz-gly-betatbuph
2057:2py-42pym-gly-betapy
2058:tolhs-24thiaz-bala-betahmofu
2059:ibhs-25thiaz-gly-betatos
2060:ibhs-nme35pyr-bala-suabu
2061:ibhs-25methiaz-gly-betamethioph
2062:ibhs-25thiaz-bala-betadito
2063:hyd-24thiaz-bala-betameph
2064:tolhs-nme35pyr-gly-betacph
2065:bhs-25oxaz-ala-betafphe
2066:bhs-oxadiaz-gly-aspbzla
2067:tolhs-24thiaz-bala-ibsdap
2068:bim-ithiadiaz-leu-betadcph
2069:2py-24thioph-gly-betaol
2070:tolhs-24thiaz-gly-betamesu

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-82
2071:ibhs-24thiaz-gly-betahdcph
2072:bhs-25methiaz-nmgly-beta3quin
2073:ibhs-24thioph-gly-betaphethio
2074:bhs-24thioph-bala-betathiobe
2075:bhs-25thiaz-gly-asppha
2076:phhs-nme35pyr-bala-betaphethioa
2077:2py-25methiaz-leu-betadcph
2078:tolhs-ithiadiaz-bala-betafphe
2079:bhs-25oxaz-bala-betadmph
2080:bhs-nme35pyr-bala-betaftrif
2081:tolhs-25methiaz-gly-betapyee
2082:bim-oxadiaz-leu-psdap
2083:tolhs-ithiadiaz-gly-betahc
2084:gua-25thiaz-gly-betahc
2085:2py-53pyrazo-gly-zdap
2086:nmhs-42pym-gly-betainyl
2087:tolhs-24thiaz-gly-betainyl
2088:phhs-25oxaz-bala-psdapch
2089:bhs-24thiaz-gly-betathiome
2090:bhs-nme35pyr-gly-betabediox
2091:phhs-25thiaz-gly-betahph
2092:bhs-24thiaz-nmgly-betabpy
2093:ibhs-25methiaz-bala-betafu3
2094:phhs-24thioph-gly-betaoxope
2095:bhs-25methiaz-gly-busu2be
2096:dhim-24thiaz-ala-zdap
2097:bhs-ithiadiaz-bala-betainyl
2098:phhs-25methiaz-gly-betaomebendi
2099:bim-52thiaz-ala-betameph
2100:bim-35thioph-bala-zdap
2101:ibhs-25thiaz-bala-aspbzla
2102:ibhs-25thiaz-gly-busu2be
2103:tolhs-nme35pyr-gly-betaomebendi
2104;phhs-25methiaz-gly-betaet
2105:bhs-24thiaz-gly-betahdcph
2106:bim-42nmeim-gly-betah35dc
2107:bhs-me24thioph-gly-betapy

CA 02371604 2001-10-24
WO OOI66618 . PCTIEP00103469
-83
2108:phhs-25thiaz-gly-zdapee
2109:ibhs-nme35pyr-bala-betadbph
2110:tolhs-me25thiaz-giy-betaph
2111:bhs-me25thioph-bala-zdap
2112:impy-25oxaz-bala-betadmoph
2113:tolhs-25thiaz-bala-betal3bendi
2114:bhs-35fur-gly-psdap
2115:gua-25thioph-gly-betaph
2116:ibhs-25oxaz-bala-betaamibe
2117:2py-24oxaz-leu-betadcph
2118:ibhs-ithiadiaz-gly-betahmofu
2119:bim-25thioph-ala-betapy
2120:ibhs-ithiadiaz-gly-betadcphee
2121:tolhs-me25oxaz-gly-betadcph
2122:tolhs-25methiaz-bala-betaheph
2123:ibhs-ithiadiaz-gly-betapy
2124:bhs-35py-ala-betapy
2125:bhs-35thioph-bala-psdap
2126:tolhs-me24thioph-bala-zdap
2127:phhs-25methiaz-gly-betahdcph
2128:bhs-25thiaz-bala-psdapee
2129:bhs-me25thioph-gly-beta34meoph
2130:phhs-oxadiaz-gly-betahdcph
2131:tolhs-25oxaz-gly-betaanaphth
2132:tolhs-25thiaz-bala-csdap
2133:2py-ithiadiaz-leu-zdap
2134:ibhs-25oxaz-bala-betamethi
2135:bhs-25oxaz-bala-aspbzla
2136:phhs-nme35pyr-bala-betah35dc
2137:ibhs-24thioph-bala-betadcphch
2138:phhs-25methiaz-bala-betathiome
2139:2py-52thiaz-ala-betapy
2140:ibhs-24thioph-gly-betabdimo
2141:dimethpym-25thiaz-gly-betameph
2142:bhs-25methiaz-gly-betaftrif
2143:tolhs-24thiaz-gly-betacph
2144:bhs-oxadiaz-bala-betapytb

CA 02371604 2001-10-24
WO OO1G6618 PCTlEP00103469
_84_
2145:ibhs-oxadiaz-bala-betafbph
2146:ibhs-25thiaz-gly-betacbph
2147:phhs-24thioph-bala-betafluo
2148:phhs-me24thiaz-bala-beta34meoph
2149:tolhs-25thiaz-bala-betapyr
2150:phhs-25oxaz-bala-betadhbfu
2151:ibhs-25oxaz-bala-betadito
2152:bhs-24thioph-gly-betameph
2153:bhs-24thioph-bala-betacbph
2154:bim-25oxaz-gly-aspbzla
2155:impy-24thioph-gly-beta34meoph
2156:bhs-ithiadiaz-nmgly-betadmoph
2157:bim-35thioph-ala-betapy
2158:tolhs-25thiaz-bala-betadmph
2159:phhs-24thioph-bala-betaphethioa
2160:ibhs-25oxaz-bala-betafu2
2161:ibhs-nme35pyr-gly-betatrif
2162:2py-24thiaz-gly-beta3quin
2163:2pmhs-25thiaz-gly-psdap
2164:bhs-25oxaz-gly-betatos
2165:tolhs-25methiaz-gly-beta3quin
2166:tolhs-24thioph-bala-betabthioph
2167:impy-25methiaz-bala-betamesu
2168:phhs-25oxaz-bala-psdapee
2169:tolhs-25thiaz-gly-betah35dc
2170:tolhs-24thioph-bala-betafu3
2171:bhs-25methiaz-gly-betabdimo
2172:bhs-25fur-gly-betadcph
2173:phhs-ithiadiaz-bala-psdapch
2174:tolhs-25oxaz-gly-betadito
2175:tolhs-oxadiaz-gly-betamesu
2176:bhs-25oxaz-bala-betabenfu
2177:ibhs-25methiaz-gly-betadcph
2178:bhs-24thioph-gly-betadito
2179:ibhs-24thiaz-bala-betaoxope
.
2180:tolhs-25methiaz-bala-betampy
2181:ibhs-ithiadiaz-bala-aspaba

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-85
2182: 2py-me25oxaz-ala-betadcph
2183: ibhs-24thioph-gly-betapytb
2184: ibhs-ithiadiaz-bala-betainyl
2185: phhs-me25thiaz-gly-psdap
2186: phhs-oxadiaz-g1y-betahb
2187: bhs-nme35pyr-ala-beta34dcph
2188: phhs-me24thiaz-ala-zdap
2189: bhs-42nmeim-leu-betapy
2190: tolhs-24thiaz-gly-betaftrif
2191:ibhs-oxadiaz-gly-betahmph
2192: tolhs-ithiadiaz-bala-betahb
2193: bhs-35thioph-leu-betadcph
2194: bhs-25thiaz-bala-betadcph
2195: phhs-nme35pyr-gly-betapyr
2196:ibhs-ithiadiaz-gly-zdap
2197: phhs-25oxaz-bala-betahdcph
2198: bhs-oxadiaz-gly-betaibph
2199: 2py-me24thioph-leu-betaph
2200: tolhs-24thioph-gly-beta34dcph
2201:bhs-24thiaz-nmgly-betacph
2202: bhs-25oxaz-bala-betapyr
2203: bhs-25fur-leu-zdap
2204: impy-24oxaz-gly-betameph
2205: bhs-nme35pyr-gly-betahb
2206:tolhs-me24thiaz-bala-psdap
2207: ibhs-24thioph-gly-beta35dbph
2208: ibhs-24thioph-bala-betathio3
2209: bhs-24thiaz-bala-asppha
2210: bhs-24thioph-ala-betaanaphth
2211:ibhs-24thioph-bala-betahph
2212: tolhs-nme35pyr-bala-asppha
2213: bim-thiadiaz-leu-zdap
2214: 2py-35fu r-bala-betapy
2215: phhs-24thioph-bala-betathioph
2216:phhs-ithiadiaz-bala-betadhbfu
2217: bhs-25thiaz-nmgly-betameph
2218: tolhs-ithiadiaz-gly-betahb

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-86
2219:2py-ithiadiaz-gly-aspibua
2220:ibhs-25methiaz-bala-betamethioph
2221:bhs-oxadiaz-gly-betaet
2222:ibhs-nme35pyr-gly-betatos
2223:bhs-me25oxaz-gly-psdap
2224:bhs-25oxaz-bafa-zdapee
2225:bhs-26py-gly-beta13bendi
2226:bhs-25fur-ala-betadcph
2227:ibhs-24thioph-gly-zdapch
2228:tolhs-25thiaz-bala-betadcphtb
2229:phhs-24thioph-bala-betadbph
2230:2py-25oxaz-bala-aspbzla
2231:2py-me25thioph-ala-beta34meoph
2232:ibhs-25thiaz-bala-beta34meoph
2233:ibhs-24thioph-bala-zdap
2234:phhs-24thiaz-bala-betathio3
2235:bhs-24thioph-bala-betatrif
2236:bhs-nme35pyr-bala-betadito
2237:phhs-nme35pyr-gly-betacbph
2238:bhs-24thioph-ala-betaoxaz
2239:impy-25thiaz-bala-betaphethioa
2240:2py-25oxaz-bala-betafu3
2241:2py-oxadiaz-ala-betapy
2242:ibhs-25methiaz-bala-betaet
2243:ibhs-ithiadiaz-gly-betatbuph
2244:phhs-24thioph-bala-betaol
2245:phhs-25thiaz-bala-beta23meoph
2246:phhs-25oxaz-bala-betabthioph
2247:bim-24im-bala-psdap
2248:bim-nme35pyr-gly-aspaba
2249:ibhs-25oxaz-bala-betaimid
2250:impy-24thiaz-gly-betaipr
2251:tolhs-25thiaz-bala-betapbiph
2252:phhs-25oxaz-bala-betadcph
2253:ibhs-ithiadiazgly-beta-4bph
2254:bhs-oxadiaz-gly-betah35dc
2255:phhs-oxadiaz-gly-betaipro

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
_87_
2256:bhs-25methiaz-nmgly-betathio3
2257:bim-35thioph-leu-zdap
2258:phhs-25oxaz-bala-betaipr
2259:ibhs-25methiaz-gly-zdapch
2260:bim-me25thiaz-bala-zdap
2261:phhs-nme35pyr-bala-betaamibe
2262:bhs-25thiaz-bala-aspaba
2263:bhs-24thiaz-gly-betathioph
2264:bhs-25oxaz-gly-betaphethio
2265:bhs-ithiadiaz-bala-betabediox
2266:phhs-nme35pyr-gly-betabnaphth
2267:bhs-nme35pyr-gly-betadtrif
2268:tolhs-25thiaz-bala-betainyl
2269:bhs-24thioph-gly-betabnaphth
2270:phhs-ithiadiaz-bala-betacbph
2271:bhs-25methiaz-bala-betatbuph
2272:bhs-25methiaz-ala-betathio3
2273:bim-25methiaz-gly-zdap
2274:tolhs-oxadiaz-gly-betafu2
2275:ibhs-24thiaz-bala-beta35dbph
2276:bhs-nme35pyr-gly-betadito
2277:bhs-oxadiaz-ala-ibsdap
2278:ibhs-25methiaz-gly-beta13bendi
2279:phhs-24thioph-bala-psdap
2280:ibhs-ithiadiaz-bala-betatos
2281:tolhs-25thiaz-gly-psdapch
2282:bhs-25methiaz-gly-betadhbfu
2283:phhs-24thiaz-gly-betaipro
2284:ibhs-oxadiaz-gly-zdap
2285:tolhs-nme35pyr-bala-betafphe
2286:bhs-25thiaz-ala-betaoxaz
2287:ibhs-24thioph-bala-betaet
2288:ibhs-24thiaz-bala-betafu3
2289:bhs-25oxaz-ala-ibsdap
2290:bhs-25methiaz-nmgly-betadito
2291:bim-24thioph-gly-betapbiph
2292:ibhs-25thiaz-bala-betadtrif

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
_88_
2293:tolhs-25methiaz-bala-betah35dc
2294:phhs-25methiaz-gly-betabdimo
2295:2py-25oxaz-bala-aspibua
2296:ibhs-25thiaz-bala-betahmofu
2297:phhs-oxadiaz-gly-betathiome
2298:tolhs-oxadiaz-gly-betaomebendi
2299:tolhs-25thiaz-gly-betabmph
2300:ibhs-oxadiaz-bala-betahdcph
2301:2py-me24thioph-leu-beta34meoph
2302:phhs-nme35pyr-gly-betabediox
2303:ibhs-nme35pyr-bala-betaibph
2304:2py-me25thioph-bala-beta34meoph
2305:bhs-24thiaz-bala-betatos
2306:bhs-25thiaz-gly-betaol
2307:phhs-25oxaz-gly-betahb
2308:ibhs-oxadiaz-bala-betaphethioa
2309:tolhs-25thiaz-bala-betahmofu
2310:bhs-nme35pyr-ala-betahph
2311:ibhs-25oxaz-bala-betaibph
2312:tolhs-25oxaz-bala-betadmph
2313:2py-me25oxaz-bala-zdap
2314:bhs-24thiaz-gly-betacph
2315:bim-oxadiaz-ala-zdap
2316:tolhs-25oxaz-bala-betamethi
2317:2py-25thioph-ala-betadcph
2318:bhs-24thiaz-nmgly-ibsdap
2319:bim-42nmeim-gly-busu2be
2320:phhs-me24thioph-ala-betadcph
2321:bhs-24thiaz-nmgly-betadhbfu
2322:2py-me25thiaz-bala-betapy
2323:bim-25thioph-gly-zdap
2324:tolhs-25oxaz-gly-betahmofu
2325:bhs-25methiaz-gly-betahmofu
2326:phhs-ithiadiaz-bala-suabu
2327:ibhs-25oxaz-gly-betamethi
2328:gua-26py-gly-betapy
2329:tolhs-25oxaz-gly-betapy

CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
_ 89
2330:bhs-me25oxaz-ala-betaph
2331:tolhs-nme35pyr-gly-betambiph
2332:bhs-24thioph-gly-betathiome
2333:phhs-25thiaz-gly-betaet
2334:tolhs-ithiadiaz-bala-betapyr
2335:phhs-24thioph-bala-zdapch
2336:tolhs-25methiaz-gly-zdap
2337:ibhs-24thiaz-gly-betacbph
2338:bhs-oxadiaz-bala-betahph
2339:tolhs-24thiaz-bala-betafu2
2340:ibhs-24thiaz-gly-psdap
2341:ibhs-ithiadiaz-bala-betabenfu
2342:bim-25oxaz-bala-psdap
2343:phhs-me25oxaz-leu-betapy
2344:ibhs-nme35pyr-bala-betabph
2345:bim-me25thioph-leu-betadcph
2346:bhs-ithiadiaz-bala-betabenfu
2347:phhs-25methiaz-bala-betabithioph
2348:bhs-nme35pyr-bala-psdapee
2349:ibhs-24thioph-bala-betabdimo
2350:ibhs-24thioph-gly-betaoxope
2351:bim-42pym-ala-zdap
2352:gua-26py-gly-suabu
2353:ibhs-25thiaz-bala-betaipro
2354:phhs-ithiadiaz-gly-betapytb
2355:2pmhs-25thiaz-gly-betameph
2356.bim-me24thioph-bala-psdap
2357:phhs-25thiaz-bala-betaphethio
2358:tolhs-oxadiaz-bala-betahbcph
2359:bhs-26py-gly-psdap
2360:bhs-24thiaz-gly-betaanaphth
2361:dhim-2thioph-gly-betameph
2362:2py-me24thioph-leu-betadcph
2363:tolhs-24thiaz-bala-betabmph
2364:bhs-25oxaz-bala-beta35dbph
2365:tolhs-25methiaz-gly-betadhbfu
2366:bhs-24thioph-bala-betafluo

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103489
-90
2367:tolhs-24thiaz-bala-betaol
2368:bim-24thioph-gly-betadbph
2369:phhs-24thioph-bala-betabph
2370:phhs-nme35pyr-bala-betacbph
2371:tolhs-ithiadiaz-bala-betadhbfu
2372:2py-24oxaz-gly-betainyl
2373:ibhs-24thioph-gly-zdaptb
2374:2py-25fur-leu-betadcph
2375:bhs-24thiaz-gly-betaimid
2376:ibhs-25methiaz-bala-beta13bendi
2377:bhs-24thiaz-bala-betapyr
2378:ibhs-24thiaz-bala-suabu
2379:tolhs-oxadia~-gly-betambiph
2380:bhs-oxadiaz-nmgly-betathioph
2381:phhs-25methiaz-gly-betabediox
2382:ibhs-25thiaz-gly-betameph
2383:phhs-24thioph-bala-betaipro
2384:bhs-24chin-ala-betameph
2385:tolhs-25oxaz-gly-betainyl
2386:2py-25oxaz-bala-betapy
2387:tolhs-25methiaz-gly-betacph
2388:ibhs-25oxaz-bala-beta
13bendi
2389:tolhs-25oxaz-gly-beta3quin
2390:ibhs-25oxaz-bala-zdap
2391:tolhs-24thioph-bala-beta13bendi
2392:phhs-me24oxaz-bala-psdap
2393:bim-24thioph-bala-betatos
2394:tolhs-me25oxaz-ala-zdap
2395:bhs-me24oxaz-bala-zdap
2396:bhs-25thiaz-bala-betadbph
2397:phhs-ithiadiaz-gly-betainyl
2398:ibhs-ithiadiaz-gly-betapytb
2399:ibhs-24thiaz-gly-betah35dc
2400:tolhs-24thiaz-gly-betatbuph
2401:phhs-24thiaz-bala-betampy
2402:bhs-53pyrazo-bala-betapy
2403:2py-25oxaz-bala-betadcph

CA 02371604 2001-10-24
WO 00/66618
PCTlEP00103469
_91_
2404: phhs-me24thioph-ieu-betapy
2405: tolhs-ithiadiaz-bala-betaanaphth
2406: ibhs-oxadiaz-bala-betaph
2407: phhs-25methiaz-gly-betafu2
2408: phhs-24thioph-gly-betadbph
2409: phhs-24thioph-bala-psdapee
2410: ibhs-24thiaz-bala-betacph
2411: bhs-me25thiaz-giy-betadcph
2412: phhs-oxadiaz-bala-betabpy
2413: ibhs-24thioph-gly-beta34dcph
2414: ibhs-25thiaz-gly-betapbiph
2415: tolhs-24thiaz-bala-beta34meoph
2416: tolhs-ithiadiaz-bala-betapbiph
2417: phhs-nme35pyr-bala-betadcph
2418: 2pmhs-25methiaz-giy-betathiome
2419: bhs-me25thiaz-bala-psdap
2420: phhs-ithiadiaz-gly-betabenfu
2421: 2py-nme35pyr-leu-betadcph
2422: phhs-24thioph-bala-betadmph
2423: bhs-24thioph-bala-betahcbph
2424: 2py-25methiaz-bala-asppha
2425: 2py-2gpy_giy-betampy
2426: ibhs-nme35pyr-gly-zdapch
2427: tolhs-me24thiaz-ala-betapy
2428: toihs-nme35pyr-gly-betapbiph
2429: phhs-ithiadiaz-gly-betapyee
2430: bhs-25oxaz-gly-beta34meoph
2431: 2py-35thioph-leu-betadcph
2432: ibhs-nme35pyr-gly-betabph
2433: bhs-ithiadiaz-gly-betaphethio
2434: tolhs-25thiaz-gly-zdapch
2435: 2py-24thioph-ala-zdap
2436: toihs-ithiadiaz-gly-betahph
2437: phhs-25methiaz-bala-betaphethioa
2438: ibhs-25oxaz-gly-betah35dc
2439: gua-25thioph-gly-betaphethio
2440: bim-35fur-gly-psdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-92
2441: ibhs-ithiadiaz-bala-betaftrif
2442: tolhs-24thiaz-gly-beta34meoph
2443: bhs-25methiaz-bala-betacthioph
2444: bhs-nme35pyr ala-betaoxaz
2445: 2py-me24thioph-gly-zdap
2446: 2py-25oxaz-gly-betambiph
2447: bhs-42nmeim-gly-psdap
2448: bhs-oxadiaz-gly-psdapee
2449: phhs-ithiadiaz-gly-betafph
2450: thazep-42pym-gay-beta13bendi
2451: phhs-25methiaz-bala-betabmph
2452: bhs-25methiaz-bala-betapbiph
2453: phhs-nme35pyr-gly-suabu
2454: ibhs-ithiadiaz-bala-betamethioph
2455: 2pmhs-24thioph-gly-betafph
2456: tolhs-24thiaz-gly-betacbph
2457: phhs-25thiaz-bala-betathio3
2458: ibhs-oxadiaz-bala-betamethioph
2459: ibhs-25thiaz-gly-aspibua
2460: bhs-42nmeim-bala-betadcph
2461: phhs-25oxaz-bala-betaomebendi
2462: phhs-nme35pyr-gly-asppha
2463: ibhs-24thiaz-baia-betainyl
2464: bim-25oxaz-gly-aspibua
2465: bhs-ithiadiaz-ala-betafphe
2466: bhs-25oxaz-bala-betafphe
2467: ibhs-ithiadiaz-gly-betaibph
2468: gua-26py-gly-betabnaphth
2469: ibhs-25oxaz-gly-betathioph
2470: phhs-25methiaz-gly-betathiobe
2471: ibhs-24thiaz-gly-betadbph
2472: tolhs-ithiadiaz-gly-betabthioph
2473: bhs-oxadiaz-gly-busu2be
2474: phhs-24thioph-gly-betaphethioa
2475: bhs-24thiaz-ala-betameph
2476: tolhs-25thiaz-bala-betaol
2477: bhs-ithiadiaz-bala-betahmofu

CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-93
2478: phhs-ithiadiaz-bala-betaph
2479: bhs-35fur-gly-betapy
2480: ibhs-24thioph-bala-betapych
2481: phhs-25oxaz-gly-beta13bendi
2482: bhs-25thiaz-ala-betadito
2483: bhs-ithiadiaz-bala-psdap
2484: bim-24thioph-bala-betaipro
2485: phhs-24thioph-bala-beta34dcph
2486: tolhs-me24thioph-leu-betapy
2487:phhs-25methiaz-gly-betahmph
2488: tolhs-oxadiaz-gly-betatbuph
2489: bhs-me24thioph-bala-zdap
2490: phhs-24thioph-gly-betahmo
2491: bhs-nme35pyr-gly-betabmph
2492:bim-24thioph-gly-zdap
2493: ibhs-25thiaz-bala-betahc
2494: ibhs-ithiadiaz-bala-zdaptb
2495: bhs-24thiaz-gly-betadcphee
2496: ibhs-24thioph-bala-betacbph
2497:ibhs-ithiadiaz-bala-betaph
2498: ibhs-25methiaz-gly-betahdcph
2499: phhs-24thiaz-bala-betafbph
2500: phhs-25oxaz-gly-betadhbfu
2501: bhs-42oxaz-leu-zdap
2502:phhs-ithiadiaz-gly-betaomebendi
2503: phhs-24thiaz-bala-beta4bph
2504: bhs-24thioph-bala-betaipro
2505: phhs-oxadiaz-bala-betahc
2506: tolhs-25oxaz-bala-betadito
2507:bhs-nme35pyr-gly-betapbiph
2508: bhs-25methiaz-gly-betameph
2509: ibhs-25oxaz-bala-beta4bph
2510: ibhs-ithiadiaz-bala-betadtrif
2511: bhs-ithiadiaz-gly-betabph
2512:bhs-25oxaz-bala-beta13bendi
2513: tolhs-25oxaz-bala-betafluo
2514: tolhs-25thiaz-bala-aspibua

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-94-
2515: ibhs-24thiaz-gly-betapytb
2516: tolhs-me25oxaz-leu-psdap
2517: phhs-25methiaz-bala-betahph
2518: bhs-24thioph-ala-betadhbfu
2519: bim-24thiaz-phg-zdap
2520: bhs-me25thiaz-bala-betapy
2521: 2py-35fur-bala-psdap
2522: phhs-me25thioph-ala-betadcph
2523: bhs-me25thiaz-gly-betaph
102524: phhs-25thiaz-gly-asppha
2525: phhs-25methiaz-gly-betadcphtb
2526: ibhs-nme35pyr-bala-betapbiph
2527: phhs-ithiadiaz-gly-betadtrif
2528: bhs-24thiaz-gly-betabdimo
152529: bhs-25methiaz-ala-betabnaphth
2530: 2py-me25thiaz-leu-zdap
2531: ibhs-24thiaz-gly-betaipr
2532: dhim-25thioph-gly-betahcbph
2533: tolhs-me24thiaz-leu-beta34imeoph
202534: bhs-25thiaz-bala-betaipro
2535: bim-me24thiaz-ala-psdap
2536: gua-25thioph-gly-betapbiph
2537: 2pmhs-24thioph-gly-betaph
2538: bhs-24thioph-bala-betaibph
252539. tolhs-24thioph-bala-betabnaphth
2540: bhs-nme35pyr-bala-betampy
2541: bim-ithiadiaz-bala-aspbzla
2542: ur-25thioph-gly-zdap
2543: bhs-24thioph-gly-betatos
302544: bhs-nme35pyr-gly-aspaba
2545: tolhs-ithiadiaz-gly-zdapch
2546: ibhs-24thioph-gly-betapyr
2547: bhs-ithiadiaz-bala-betaibph
2548: bhs-25methiaz-bala-betathiobe
352549: ibhs-25thiaz-bala-beta13bendi
2550: bhs-24thioph-ala-betainyl
2551: 2pmhs-25oxaz-gly-betadito

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-95
2552:tolhs-oxadiaz-bala-ibsdap
2553:bim-me24oxaz-leu-betadcph
2554:phhs-25thiaz-bala-betainyl
2555:phhs-me24oxaz-bala-betaph
2556:bhs-23thioph-gly-betapy
2557:tolhs-25methiaz-bala-betafbph
2558:bhs-oxadiaz-bala-betabenfu
2559:phhs-24thiaz-gly-betadcph
2560:phhs-25oxaz-gly-betaomebendi
2561:tolhs-nme35pyr-gly-betadcph
2562:ibhs-24thioph-bala-zdapch
2563:tolhs-nme35pyr-gly-betah35dc
2564:ibhs-25thiaz-gly-betabthioph
2565:tolhs-24thioph-gly-betabediox
2566:bhs-25thiaz-gly-betathiobe
2567:phhs-oxadiaz-bala-beta3quin
2568:ibhs-25thiaz-gly-betaph
2569:phhs-25thiaz-gly-betampy
2570:ibhs-nme35pyr-gly-betabdimo
2571:2py-25methiaz-hphe-psdap
2572:phhs-ithiadiaz-gly-betahni
2573:bhs-nme35pyr-ala-betafphe
2574:2py-52thiaz-ala-betameph
2575:gua-24thiaz-gly-betafph
2576:ibhs-24thioph-bala-beta4bph
2577:bhs-24thiaz-bala-betaheph
2578:ibhs-25methiaz-giy-betaph
2579:phhs-nme35pyr-gly-betahcbph
2580:phhs-ithiadiaz-bala-betah35dc
2581:bhs-oxadiaz-bala-beta23meoph
2582:bim-25thiaz-gly-betaibph
2583:tolhs-25methiaz-bala-beta34dcph
2584:tolhs-24thioph-gly-zdapee
2585:tolhs-oxadiaz-gly-betahmo
2586:4pmhs-24oxaz-gly-betameph
2587:ibhs-ithiadiaz-bala-betafbph
2588:bhs-oxadiaz-bala-betaftrif

CA 02371604 2001-10-24
WO 00/66618 PCTlEP00103469
-96
2589: gua-24oxaz-gly-betafu2
2590: tolhs-me24thiaz-gly-betadcph
2591: bhs-25thiaz-bala-betathiome
2592: impy-25oxaz-gly-betameph
2593:ibhs-25thiaz-bala-betafbph
2594: tolhs-24thiaz-bala-betaipro
2595: tolhs-25oxaz-bala-betapytb
2596: bim-me24thioph-leu-betapy
2597: tolhs-24thioph-gly-betaphethio
2598:Zpy-25thioph-gly-psdap
2599: bhs-25thiaz-gly-betahmo
2600: tolhs-oxadiaz-bala-aspaba
2601: bhs-oxadiaz-leu-zdap
2602: hs-24thiaz-bafa-betapy
2603:bhs-25thiaz-gly-betaoxope
2604: bhs-24thioph-bala-betathioph
2605: tolhs-ithiadiaz-bala-betabpy
2606: phhs-ithiadiaz-gly-betamethi
2607: phhs-24thiaz-gly-betatrif
2608:ibhs-nme35pyr-gly-betahmph
2609: phhs-25oxaz-bala-betacbph
2610: tolhs-25thiaz-gly-asppha
2611: bhs-25thiaz-bala-betahc
2612: tolhs-25thiaz-gly-betaph
2613:bhs-ithiadiaz-gly-zdapee
2614: bhs-25oxaz-bala-betamesu
2615: bhs-nme35pyr-gly-betahc
2616: tolhs-me25thiaz-gly-betapy
2617: bhs-oxadiaz-bala-betafph
2618:bim-nme35pyr-leu-betadcph
2619: tolhs-nme35pyr-bala-betamesu
2620: dhim-25thiaz-gly-betameph
2621: tolhs-me25thioph-ala-betapy
2622: ibhs-oxadiaz-bala-betaamibe
2623:impy-24thiaz-gly-betabthioph
2624: ibhs-25oxaz-bala-betaph
2625: bhs-25methiaz-gly-betapych

CA 02371604 2001-10-24
WO 0016661$ PCTIEP00103469
_97_
2626:bhs-25methiaz-gly-betambiph
2627:tolhs-25oxaz-gly-betadtrif
2628:bhs-25methiaz-nmgly-betadmph
2629:bhs-25thiaz-ala-betabpy
2630:ibhs-25oxaz-gly-betacthioph
2631:2py-24thioph-gly-betacthioph
2632:bhs-24thioph-gly-betadcphee
2633:ibhs-25oxaz-gly-betadbph
2634:phhs-24thiaz-gly-betapym
2635:tolhs-nme35pyr-bala-betathiome
2636:bhs-ithiadiaz-ala-betadmph
2637:bhs-25thiaz-bala-betahmo
2638:bhs-25methiaz-nmgly-betahph
2639:tolhs-nme35pyr-gly-betameph
2640:ibhs-25methiaz-gly-betaomebendi
2641:bim-25oxaz-bala-beta4bph
2642:2py-24thiaz-gly-betainyl
2643:bhs-ithiadiaz-bala-betaipr
2644:bhs-25thiaz-bala-betahdbph
2645:ibhs-25oxaz-gly-betahcbph
2646:tolhs-24thiaz-bala-betaibph
2647:2py-25fur-gly-psdap
2648:phhs-25thiaz-bala-betaph
2649:bhs-24thiaz-gly-betapy
2650:ibhs-nme35pyr-bala-betabthioph
2651:tolhs-ithiadiaz-gly-betainyl
2652:dhpyrr-42nmeim-gly-zdap
2653:bhs-nme35pyr-gly-csdap
2654:gua-25thiaz-gly-betatos
2655:bhs-24thioph-gly-betatbuph
2656:ibhs-25oxaz-bala-betatbuph
2657:bhs-25thiaz-bala-betabenfu
2658:ibhs-nme35pyr-gly-betapy
2659:2py-26py-gly-ibsdap
2660:2py-24thiaz-bala-aspibua
2661:bhs-oxadiaz-gly-betabediox
2662:phhs-nme35pyr-bala-betafu2

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
_98_
2663:bhs-thiadiaz-ala-betadcph
2664;bhs-oxadiaz-bala-betaheph
2665;bhs-25thiaz-gly-beta34meoph
2666:bhs-25methiaz-bala-betadmph
2667:bhs-25thiaz-bala-betaftrif
2668:ibhs-24oxaz-gly-zdap
2669:tolhs-ithiadiaz-bala-betah35dc
2670:2py-24thiaz-bala-betafluo
2671:agua-24thiaz-gly-betainyl
2672:bim-25methiaz-bala-aspaba
2673:bhs-25thiaz-gly-betahmph
2674:phhs-25thiaz-bala-betaet
2675:bhs-25thiaz-bala-psdapch
2676:phhs-oxadiaz-gly-betadcph
2677:2py-42nmeim-nmala-betapy
2678:ibhs-26py-gly-betainyl
2679:phhs-25methiaz-gly-ibsdap
2680:bim-42pym-ala-psdap
2681:phhs-24thiaz-bala-betahph
2682:tolhs-24thioph-gly-betabdimo
2683:ibhs-25oxaz-bala-betatrif
2684:bhs-nme35pyr-ala-zdap
2685:bhs-25fur-bala-betapy
2686:phhs-24thioph-gly-betabnaphth
2687:tolhs-nme35pyr-bala-betathioph
2688:phhs-25methiaz-bala-betaamibe
2689:tolhs-24thiaz-bala-betafbph
2690:ibhs-oxadiaz-gly-psdaptb
2691:tolhs-nme35pyr-gly-suabu
2692:tolhs-25methiaz-gly-betabnaphth
2693:bhs-25oxaz-mngly-betabnaphth
2694:ibhs-25thiaz-bala-betapytb
2695:tolhs-nme35pyr-bala-psdapee
2696:2py-24thioph-gly-betadcph
2697:sabhs-25thiaz-ala-betameph
2698:bhs-25methiaz-gly-betathio3
2699:ibhs-25methiaz-gly-psdaptb

CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
_99_
2700:bhs-nme35pyr-gly-betapym
2701:ibhs-25thiaz-gly-ibsdap
2702:impy-25methiaz-bala-betaftrif
2703:tolhs-25methiaz-gly-betafluo
2704:ibhs-25oxaz-bala-betaoxope
2705:gua-26py-gly-betafbph
2706:bhs-nme35pyr-bala-betahb
2707:ibhs-nme35pyr-bala-betapyee
2708:bhs-24oxaz-bala-psdap
2709:bhs-25oxaz-bala-betahdbph
2710:phhs-25oxaz-bala-zdap
2711:phhs-25methiaz-gly-betah35dc
2712:ibhs-25thiaz-bala-betacph
2713:tolhs-25thiaz-gly-betaamibe
2714:bhs-ithiadiaz-bala-betahmo
2715:tolhs-24thiaz-gly-suabu
2716:phhs-nme35pyr-gly-betaol
2717:phhs-24thiaz-bala-betapbiph
2718:bhs-oxadiaz-nmgly-betadito
2719:tolhs-ithiadiaz-gly-betaanaphth
2720:tolhs-25thiaz-gly-busu2be
2721:bim-24im-ala-betadcph
2722:ibhs-25thiaz-gly-betahmofu
2723:tolhs-oxadiaz-bala-betaomebendi
2724:bhs-ithiadiaz-gly-betadtrif
2725:ibhs-25methiaz-gly-betathioph
2726:phhs-25methiaz-bala-betahdbph
2727:bhs-nme35pyr-bala-betaol
2728:gua-26py-gly-betahc
2729:ibhs-25oxaz-bala-beta34meoph
2730:bim-25methiaz-bala-betahcbph
2731:phhs-nme35pyr-bala-betafph
2732:tolhs-25oxaz-bala-betaet
2733:2py-nme35pyr-gly-betadcph
2734:tolhs-oxadiaz-gly-betaol
2735:bhs-24im-ala-zdap
2736:2py-35thioph-gly-betadcph

CA 02371604 2001-10-24
WO 00166618 PCT/EPOO103469
- 100
2737:tolhs-25methiaz-gly-psdapee
2738:impy-25methiaz-bala-psdap
2739:ibhs-25methiaz-bala-betabediox
2740:tolhs-nme35pyr-bala-betaphethioa
2741:tolhs-ithiadiaz-gly-betahbcph
2742:thazep-24thioph-bala-zdap
2743:dhim-25py-gly-betameph
2744:2py-25fur-gly-betapy
2745:impy-42nmeim-gly-betabmph
2746:tolhs-24thioph-gly-betacbph
2747:phhs-oxadiaz-bala-betaftrif
2748:tolhs-25thiaz-bala-betacph
2749:phhs-24thiaz-bala-betadito
2750:bhs-25fur-ala-betapy
2751:ibhs=25oxaz-gly-betahb
2752:tolhs-24thiaz-bala-zdapee
2753:bhs-25oxaz-gly-betahmo
2754:gua-24thiaz-gly-betamethioph
2755:nmhs-24thiaz-gly-betapy
2756:phhs-25thiaz-gly-betafph
2757:tolhs-25oxaz-gly-betadmoph
2758:phhs-oxadiaz-bala-betaet
2759:bhs-24thiaz-gly-psdapee
2760:ibhs-24thiaz-bala-betabediox
2761:gua-24thiaz-gly-betafu3
2762:tolhs-nme35pyr-bala-betaphethio
2763:ibhs-24thioph-gly-psdap
2764:tolhs-me24oxaz-leu-beta34meoph
2765:2py-24thioph-bala-aspaba
2766:bim-me24oxaz-leu-psdap
2767:bhs-nme35pyr-bala-betamesu
2768:bhs-thiadiaz-gly-zdap
2769:2py-oxadiaz-ala-zdap
2770:bim-25methiaz-gly-betapbiph
2771:ibhs-24thioph-gly-betadcphee
2772:tolhs-nme35pyr-bala-betahdcph
2773:bhs-me24thioph-gly-betadcph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-101
2774:phhs-25thiaz-bala-zdapch
2775:bhs-25thiaz-gly-betapych
2776:bhs-ithiadiaz-bala-betahdbph
2777:impy-24thiaz-nmgly-psdap
2778:bim-25oxaz-bala-beta13bendi
2779:bim-oxadiaz-bala-betapy
2780:tolhs-24thiaz-bala-betahdcph
2781:2py-nme35pyr-ala-psdap
2782:ibhs-25thiaz-gly-betadtrif
2783:phhs-25thiaz-gly-betahbcph
2784:ibhs-oxadiaz-bala-zdapch
2785:dhim-26py-hphe-zdap
2786:phhs-nme35pyr-gly-betahbcph
2787:bhs-25thiaz-bala-betafluo
2788:ibhs-oxadiaz-gly-beta3quin
2789:2py-35fur-bala-betadcph
2790:2py-me25oxaz-gly-betadcph
2791:bhs-24thiaz-gly-betaipr
2792:bhs-25methiaz-bala-betabediox
2793:ibhs-ithiadiaz-gly-betaph
2794:phhs-25thiaz-bala-aspibua
2795:tolhs-oxadiaz-bala-betabdimo
2796:2py-me24thiaz-ala-betapy
2797:impy-25methiaz-ala-betapy
2798:phhs-nme35pyr-bala-betabnaphth
2799:bim-me25oxaz-leu-betapy
2800:gua-me24thiaz-gly-betapy
2801:2py-24im-gly-betapy
2802:bhs-25thiaz-bala-betapbiph
2803:bhs-24thioph-bala-ibsdap
2804:2py-35thioph-leu-betapy
2805:bhs-25thiaz-ala-beta3quin
2806:ibhs-24thioph-bala-csdap
2807:bhs-53pyrazo-bala-zdap
2808:bhs-42nmeim-gly-betapy
2809:phhs-25oxaz-gly-betathioph
2810:ibhs-25methiaz-gly-betabpy

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-102
2811:ibhs-24thiaz-bala-betapyee
2812:bhs-25thiaz-nmgly-betaipro
2813:bhs-25methiaz-bala-betampy
2814:bhs-24thioph-bala-betamesu
2815:bim-me24oxaz-bala-zdap
2816:bhs-25methiaz-gly-betaph
2817:bim-25thiaz-gly-zdap
2818:bhs-nme35pyr-gly-betatbuph
2819:bhs-25oxaz-ala-betadhbfu
2820:ibhs-ithiadiaz-bala-betaphethioa
2821:bhs-oxadiaz-g1y-betathiome
2822:phhs-24thioph-bala-betabediox
2823:bhs-25thiaz-bala-betathioph
2824:phhs-oxadiaz-bala-betaipr
2825:bim-me25thioph-gly-betadcph
2826:bhs-25oxaz-gly-betameph
2827:bhs-oxadiaz-gly-beta13bendi
2828:ibhs-oxadiaz-gly-zdapee
2829:2py-me24thioph-bala-psdap
2830:bhs-25thiaz-bala-betacbph
2831:2py-me25oxaz-leu-betadcph
2832:tolhs-25thiaz-bala-betahcbph
2833:ibhs-25oxaz-bala-betabdimo
2834:2py-25thioph-ala-betainyl
2835:bhs-oxadiaz-bala-betathioph
2836:bhs-25methiaz-gly-betaipro
2837:bhs-24thioph-ala-betapy
2838:ibhs-25thiaz-gly-betafluo
2839:2py-24oxaz-gly-zdap
2840:phhs-oxadiaz-bala-betadcphee
2841:2py-24thiaz-ala-betadcph
2842:ibhs-24thiaz-gly-betaheph
2843:bhs-me25oxaz-ala-betapy
2844:ibhs-nme35pyr-bala-betaomebendi
2845:bhs-thiadiaz-gly-betapy
2846:bhs-25thiaz-gly-betadhbfu
2847:dhim-24oxaz-gly-betapy

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-103
2848:gua-24thiaz-gly-betafluo
2849:bhs-thiadiaz-bala-zdap
2850:ibhs-25oxaz-gly-betahni
2851:tolhs-25thiaz-bala-betahc
2852:bhs-nme35pyr-ala-ibsdap
2853:bhs-oxadiaz-gly-betabdimo
2854:phhs-me24thiaz-leu-betaph
2855;tolhs-25thiaz-bala-betathioph
2856:bhs-25oxaz-bala-betatrif
2857:ibhs-24thiaz-gly-betamesu
2858:bim-25thiaz-ala-betainyl
2859:bhs-me25thiaz-leu-zdap
2860:tolhs-me24thiaz-bala-betadcph
2861:ibhs-25oxaz-gly-betacph
2862:bim-26py-ala-zdap
2863:bhs-oxadiaz-nmgly-betacph
2864:ibhs-25methiaz-gly-beta3quin
2865:2py-me25thiaz-gly-zdap
2866:2pmhs-24thioph-bala-betahph
2867:impy-25methiaz-bala-betafu3
2868:phhs-nme35pyr-gly-betamesu
2869:ibhs-oxadiaz-gly-betaphethioa
2870:tolhs-24thioph-bala-betathioph
2871:ibhs-25oxaz-gly-psdaptb
2872:bim-25methiaz-gly-betapy
2873:2py-25oxaz-ala-zdap
2874:phhs-24thiaz-gly-betadtrif
2875:bhs-oxadiaz-bala-betacthioph
2876:2py-nme35pyr-gly-aspbzla
2877:ibhs-25oxaz-gly-betafu2
2878:ibhs-24thioph-bala-betahb
2879:bim-me25oxaz-bala-zdap
2880:bim-42nmeim-bala-beta34meoph
2881:bim-me24thiaz-gly-betapy
2882:phhs-25methiaz-gly-csdap
2883:bhs-ithiadiaz-gly-betapym
2884:phhs-24thioph-bala-betacbph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 104
2885:bhs-25oxaz-gly-betafu3
2886:2py-24im-leu-psdap
2887:bhs-me25thioph-ala-betadcph
2888:tolhs-25thiaz-gly-betadcphee
2889:bhs-25oxaz-bala-ibsdap
2890:2py-me24thiaz-bala-zdap
2891:bhs-me25thioph-gly-betaph
2892:phhs-nme35pyr-bala-betaet
2893:bim-24thiaz-gly-betaanaphth
2894:bhs-24thiaz-ala-betathioph
2895:bhs-53pyrazo-leu-zdap
2896:2py-42nmeim-bala-betahmph
2897:2py-me25oxaz-gly-betapy
2898:tolhs-24thioph-gly-betamethi
2899:bhs-24thioph-bala-betadbph
2900:ibhs-25thiaz-gly-beta35dbph
2901:phhs-24thioph-bala-aspbzla
2902:tolhs-24thioph-bala-beta35dbph
2903:bhs-nme35pyr-baia-betaipr
2904:bim-me24thiaz-bala-beta34meoph
2905:ibhs-24thioph-gly-betamesu
2906:2py-me25thioph-gly-betaph
2907:dhim-25thioph-ala-psdap
2908:impy-24thiaz-ala-betapy
2909:tolhs-nme35pyr-gly-betahbcph
2910:tolhs-oxadiaz-gly-betacthioph
2911:bhs-nme35pyr-gly-betahph
2912:tolhs-25oxaz-gly-betaipro
2913:phhs-25vxaz-bala-betahni
2914:ibhs-25methiaz-bala-csdap
2915:2py-25thiaz-ala-psdap
2916:tolhs-me24oxaz-gly-psdap
2917:ibhs-ithiadiaz-gly-betaftrif
2918:phhs-nme35pyr-gly-betadtrif
2919:2pmhs-25methiaz-bala-beta13bendi
2920:bhs-oxadiaz-nmgly-beta34dcph
2921:bim-25thiaz-bala-betaipro

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 105
2922:phhs-oxadiaz-gly-betabthioph
2923:bhs-24thioph-gly-betahmo
2924:phhs-24thioph-bala-betahmofu
2925:tolhs-me24thiaz-leu-betaph
2926:tolhs-25thiaz-bala-betahbcph
2927:ibhs-ithiadiaz-gly-beta13bendi
2928:tolhs-ithiadiaz-gly-suabu
2929:bim-26py-ala-betapy
2930:ibhs-24thioph-bala-betacthioph
102931:ibhs-25thiaz-gly-betaet
2932:phhs-nme35pyr-gly-betaoxope
2933:bim-35fur-gly-betapy
2934:phhs-oxadiaz-gly-betafu2
2935:bhs-52thiaz-ala-betadcph
152936:tolhs-25methiaz-bala-betahmph
2937:ibhs-25thiaz-bala-betaftrif
2938:tolhs-oxadiaz-bala-zdap
2939:bim-me25thioph-ala-beta34meoph
2940:gua-42pym-gly-beta35dbph
202941:gua-26py-gly-betabpy
2942:4pmhs-25thiaz-gly-zdap
2943:tolhs-oxadiaz-gly-betaphethioa
2944:tolhs-nme35pyr-gly-betatbuph
2945:gua-26py-gly-betahbcph
25294fi:bhs-25thiaz-bala-betacthioph
2947:ibhs-24thioph-bala-suabu
2948:ibhs-24thiaz-gly-betacph
2949:ibhs-nme35pyr-gly-betaftrif
2950:2py-me25thiaz-gly-betadcph
302951:2py-24oxaz-ala-zdap
2952:agua-24thiaz-gly-betadcph
2953:impy-42nmeim-bala-betahb
2954:bhs-25oxaz-bala-betabdimo
2955:phhs-nme35pyr-bala-zdap
352956:bhs-me24thiaz-leu-zdap
2957:tolhs-24thiaz-bala-beta23meoph
2958:bhs-triaz-gly-betameph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-106-
2959:bhs-ithiadiaz-gly-betathio3
2960:ibhs-nme35pyr-bala-betafph
2961:gua-24thiaz-gly-betahni
2962:bhs-25thiaz-nmgly-betacthioph
2963:tolhs-25oxaz-bala-betadcphch
2964:phhs-25thiaz-bala-betafu3
2965:tolhs-ithiadiaz-bala-zdaptb
2966:ibhs-ithiadiaz-gly-betaipro
2967:bhs-25oxaz-ala-betaoxaz
'
2968:phhs-ithiadiaz-gly-betaipr
2969:bhs-nme35pyr-bafa-betabenfu
2970:2py-52thiaz-ala-psdap
2971:bhs-24thioph-gly-betabpy
2972:dhthi-25methiaz-bala-betadcph
2973:ibhs-24thioph-gly-betaomebendi
2974:tolhs-nme35pyr-gly-betadcphch
2975:bhs-25thiaz-bala-betaanaphth
2976:bhs-25methiaz-ala-betaoxaz
2977:tolhs-25methiaz-bala-betadmph
2978:2py-42nmeim-gly-betadcph
2979:bhs-35thioph-gly-betadcph
2980:phhs-nme35pyr-bala-betahmofu
2981:ibhs-25methiaz-gly-betahmph
2982:tolhs-ithiadiaz-gly-betapym
2983:bhs-ithiadiaz-gly-betadcphee
2984:bim-53pyrazo-bala-betadcph
2985:tolhs-25oxaz-bala-betabph
2986:ibhs-25oxaz-giy-betahph
2987:tolhs-25oxaz-gly-betampy
2988:ibhs-oxadiaz-bala-zdaptb
2989:bhs-oxadiaz-bala-betafbph
2990:tolhs-25oxaz-gly-betaipr
2991:bim-me24thioph-bala-beta34meoph
2992:bhs-42pym-gly-betadcph
2993:phhs-25methiaz-bala-betadtrif
2994:2py-25oxaz-gly-betaipr
2995:phhs-oxadiaz-bala-betacbph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 107
2996:ibhs-24thioph-gly-betaoxaz
2997:tolhs-ithiadiaz-gly-betaftrif
2998:bhs-nme35pyr-nmgly-betaoxaz
2999:bhs-25thiaz-ala-betabnapbth
3000:phhs-24thioph-gly-betacbph
3001:bhs-me25thioph-leu-betapy
3002:bhs-me24thiaz-ala-betadcph
3003:ibhs-25thiaz-bala-betaol
3004:ibhs-25methiaz-gly-betabediox
103005:phhs-25thiaz-gly-betaipr
3006:bim-24oxaz-bala-zdap
3007:bhs-25oxaz-bala-zdapch
3008:3pmhs-25thiaz-bala-betapy
3009:tolhs-25methiaz-bala-betafluo
153010:bhs-ithiadiaz-gly-betapbiph
3011:phhs-24thiaz-gly-beta23meoph
3012:bhs-nme35pyr-gly-betadhbfu
3013:ibhs-25oxaz-bala-aspaba
3014:thpym-24thiaz-gly-betadcph
203015:bhs-oxadiaz-gly-betafbph
3016:2py-25thiaz-leu-psdap
3017:2py-53pyrazo-ala-psdap
3018:ibhs-nme35pyr-bala-beta23meoph
3019:tolhs-24thioph-gly-betahni
253020:ibhs-24thioph-gly-betamethioph
3021:bhs-25methiaz-bala-betahc
3022:phhs-oxadiaz-bala-betamethioph
3023:ibhs-25methiaz-bala-aspaba
3024:bim-24thioph-gly-betaomebendi
303025:tolhs-ithiadiaz-gly-betapytb
3026:bim-25methiaz-gly-betatrif
3027:2py-me25thiaz-gly-betaph
3028:phhs-25oxaz-bala-betabpy
3029:phhs-nme35pyr-gly-betahph
353030:tolhs-ithiadiaz-gly-betabmph
3031:tolhs-25methiaz-gly-betahni
3032:phhs-25methiaz-bala-betaomebendi

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 108
3033:tolhs-oxadiaz-gly-betamethi
3034:ibhs-24thiaz-bala-csdap
3035:ibhs-ithiadiaz-gly-betaomebendi
3036:tolhs-oxadiaz-bala-betamesu
3037:bhs-24thioph-gly-psdapch
3038:phhs-24thioph-gly-zdap
3039:2py-25oxaz-bala-psdap
3040:bhs-me24thiaz-ala-betapy
3041:tolhs-24thioph-bala-beta34dcph
3042:2py-25thioph-leu-betadcph
3043:bhs-25methiaz-gly-betafluo
3044:tolhs-25oxaz-gly-betahmph
3045:tolhs-nme35pyr-bala-betacbph
3046:ibhs-25thiaz-bala-betahni
3047:sabhs-25methiaz-gly-psdap
3048:ibhs-ithiadiaz-gly-zdapee
3049:ibhs-nme35pyr-gly-betafph
3050:bim-25thioph-bala-betadcph
3051:phhs-25oxaz-bala-betahph
3052:phhs-nme35pyr-bala-aspaba
3053:ibhs-24thioph-gly-beta4bph
3054:bhs-25thiaz-gly-betatrif
3055:bhs-25thiaz-bala-betathio3
3056:tolhs-ithiadiaz-gly-betathio3
3057:tolhs-ithiadiaz-bala-zdap
3058:bim-24thiaz-bala-betatos
3059:tolhs-25oxaz-gly-suabu
3060:bhs-24thioph-bala-betapbiph
3061:ibhs-oxadiaz-bala-betabnaphth
3062:bim-42nmeim-gly-zdap
3063:phhs-me25thiaz-leu-betapy
3064:bhs-25methiaz-gly-betamesu
3065:bhs-me25thiaz-gly-psdap
3066:tolhs-me25oxaz-bala-zdap
3067:bim-53pyrazo-ala-betapy
3068:phhs-ithiadiaz-bala-beta34dcph
3069:ibhs-25thiaz-gly-betapyee

CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-109
3070: tolhs-25thiaz-bala-betaoxope
3071: ibhs-25methiaz-gly-betampy
3072: tolhs-24thiaz-gly-betaoxope
3073: bhs-oxadiaz-gly-beta34meoph
3074: tolhs-ithiadiaz-bala-betaoxaz
3075: phhs-24thioph-gly-betadcphch
3076: 2py-me24thiaz-bala-psdap
3077: bhs-25thiaz-ala-betainyl
3078: phhs-25thiaz-gly-betahdcph
3079:phhs-25thiaz-gly-betah35dc
3080: tolhs-25methiaz-gly-betathio3
3081: 2py-me24thioph-gly-betaph
3082: bhs-24thioph-bala-betaoxope
3083: bhs-24thiaz-bala-aspbzla
3084:phhs-25thiaz-bala-betamethioph
3085: tolhs-25thiaz-bala-betadcphee
3086: bhs-24thioph-feu-betadcph
3087: ibhs-24thioph-gly-ibsdap
3088: phhs-nme35pyr-gly-betaibph
3089:phhs-25thiaz-bala-betahdbph
3090: bgua-24thiaz-gly-psdap
3091: bhs-25oxaz-gly-betadcph
3092: phhs-nme35pyr-bala-betaol
3093: tolhs-ithiadiaz-bala-betaibph
3094:phhs-25thiaz-bala-betacph
3095: ibhs-nme35pyr-bala-betabediox
3096: tolhs-ithiadiaz-gly-betapych
3097: bhs-nme35pyr-gly-psdap
3098: phhs-25thiaz-gly-betahb
3099:phhs-24thiaz-gly-betafu2
3100: tolhs-ithiadiaz-bala-betadcph
3101: ibhs-25oxaz-gly-betabph
3102: gua-24oxaz-gly-betapym
3103: tolhs-25thiaz-bala-betabediox
3104:bim-thiadiaz-bala-psdap
3105: tolhs-24thiaz-bala-betamethi
3106: bhs-24thioph-gly-betaol

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 110
3107: bim-25thioph-bala-psdap
3108: tolhs-25oxaz-gly-aspbzla
3109: tolhs-24thioph-bala-betaamibe
3110: bhs-me24thiaz-gly-betapy
3111: ibhs-oxadiaz-bala-betadmoph
3112: tolhs-25thiaz-bala-betabmph
3113: phhs-25thiaz-bala-betabmph
3114: phhs-25oxaz-bala-beta34meoph
3115: phhs-25methiaz-gly-asppha
103116: bhs-25methiaz-bala-betatrif
3117: bim-me24thiaz-leu-psdap
3118: ibhs-25thiaz-gly-betabdimo
3119: gua-25oxaz-gly-zdap
3120: bhs-25oxaz-gly-betahmph
153121: bim-42pym-gly-betapy
3122: ibhs-25thiaz-gly-psdaptb
3123: bhs-25oxaz-bala-beta4bph
3124: bhs-ithiadiaz-gly-betahcbph
3125: ibhs-25thiaz-bala-zdapch
203126: ibhs-nme35pyr-bala-busu2be
3127: bhs-24oxaz-ala-betadcph
3128: bhs-25methiaz-gly-betapyee
3129: ibhs-24thiaz-bala-betabph
3130: phhs-ithiadiaz-bala-betabnaphth
253131: ibhs-ithiadiaz-bala-zdapch
3132: bhs-nme35pyr-nmgly-betaipro
3133: bhs-25thiaz-bala-csdap
3134: tolhs-ithiadiaz-bala-betathiobe
3135: bhs-24thiaz-gly-betadcph
303136: dhim-25thiaz-gly-betadcph
3137: tolhs-25oxaz-bala-betatrif
3138: impy-24thioph-ala-betapy
3139: phhs-25methiaz-gly-betathio3
3140: gua-24thiaz-gly-betapyr
353141: impy-24thiaz-bala-betaftrif
3142: phhs-nme35pyr-bala-betahni
3143: 2py-42nmeim-bala-psdap

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 111
3144: ibhs-25thiaz-bala-asppha
3145: phhs-24thioph-bala-psdapch
3146: tolhs-24thiaz-gly-betadmph
3147: bim-24thiaz-gly-betadbph
3148: bhs-42pym-gly-betapy
3149: phhs-25methiaz-bala-betafluo
3150: 2py-35thioph-ala-zdap
3151: tolhs-24thiaz-bala-betaoxaz
3152: phhs-24thioph-bala-betatos
3153:tolhs-oxadiaz-bala-beta23meoph
3154: bhs-ithiadiaz-nmgly-betabpy
3155: tolhs-nme35pyr-bala-betameph
3156: tolhs-ithiadiaz-gly-betacph
3157: bhs-24oxaz-ala-betapy
3158:2py-24thioph-bala-zdap
3159: bim-25thiaz-bala-betahcbph
3160: phhs-25thiaz-gly-betathiobe
3161: bhs-24thioph-bala-busu2be
3162: phhs-me25oxaz-bala-psdap
3163:phhs-25thiaz-gly-betatos
3164: bhs-25thiaz-nmgly-betabnaphth
3165: tolhs-24thioph-gly-betadcphtb
3166: ibhs-ithiadiaz-gly-betacph
3167: phhs-ithiadiaz-bala-betahph
3168:ibhs-ithiadiaz-bala-betaet
3169: phhs-25methiaz-bala-ibsdap
3170: tolhs-25methiaz-gly-betahdcph
3171: ibhs-25oxaz-bala-betahmofu
3172: bhs-24thioph-gly-betahmofu
3173:2py-me25oxaz-bala-betadcph
3174: bhs-nme35pyr-bala-betacthioph
3175: ibhs-24thioph-bala-betaipro
3176: bim-25methiaz-gly-betahmph
3177: sabhs-26py-gly-betainyl
3178:phhs-ithiadiaz-gly-psdapch
3179: bim-me25oxaz-bala-betaph
3180: phhs-oxadiaz-bala-betaphethioa

CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
-112
3181:tolhs-ithiadiaz-bala-betainyl
3182:bhs-24thioph-nmgly-betadhbfu
3183:phhs-25methiaz-gly-betaol
3184:phhs-ithiadiaz-bala-betabph
3185:2py-me25thioph-ala-zdap
3186:bim-ithiadiaz-bala-aspaba
3187:dhim-26py-nmgly-zdap
3188:2py-24thioph-ala-betapy
3189:tolhs-25oxaz-gly-betafu3
3190:tolhs-25oxaz-bala-betahdcph
3191:bhs-ithiadiaz-gly-betatbuph
3192:2py-25methiaz-bala-betahni
3193:bhs-24thiaz-ala-betaipro
3194:bhs-24thiaz-gly-aspaba
3195:ibhs-nme35pyr-bala-aspibua
3196:bhs-25methiaz-bala-betabmph
3197:bhs-25methiaz-ala-betamesu
3198:bhs-nme35pyr-bala-betadcph
3199:impy-42nmeim-bala-betapy
3200:ibhs-25methiaz-bala-betadbph
3201:ibhs-ithiadiaz-bala-asppha
3202:tolhs-25methiaz-bala-betatrif
3203:ibhs-ithiadiaz-bala-betapym
3204:bhs-nme35pyr-nmgly-betathioph
3205:tolhs-me25oxaz-bala-psdap
3206:tolhs-24thioph-bala-betatbuph
3207:bhs-ithiadiaz-bala-busu2be
3208:tolhs-oxadiaz-bala-aspibua
3209:phhs-ithiadiaz-gly-betafphe
3210:ibhs-25methiaz-gly-betahdbph
3211:bhs-me24oxaz-gly-psdap
3212:bhs-46pym-a1a-zdap
3213:bim-25thioph-ala-betainyl
3214:phhs-24thioph-gly-betampy
3215:gua-26py-gly-betaftrif
3216:ibhs-25thiaz-bala-betabmph
3217:ibhs-oxadiaz-gly-betadcph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 113
3218:2pmhs-25methiaz-bala-betabmph
3219:bim-ithiadiaz-gly-asppha
3220:phhs-25methiaz-gly-beta34dcph
3221:tolhs-24thioph-gly-betahcbph
3222:bhs-ithiadiaz-nmgly-betafphe
3223:ibhs-ithiadiaz-gly-betaphethio
3224:phhs-25oxaz-bala-zdapch
3225:ibhs-oxadiaz-gly-betamesu
3226:tolhs-oxadiaz-bala-betadcphee
3227:tolhs-ithiadiaz-gly-aspaba
3228:impy-24thioph-bala-busu2be
3229:bhs-24thioph-leu-zdap
3230:ibhs-oxadiaz-bala-betaftrif
3231:gua-26py-gly-betapbiph
3232:ibhs-oxadiaz-gly-betapytb
3233:bim-25fur-gly-betadcph
3234:bhs-24thiaz-gly-psdaptb
3235:ibhs-ithadiaz-gly-beta34meoph
3236:tolhs-25thiaz-bala-betadcphch
3237:phhs-24thioph-bala-betahb
3238:2py-25thiaz-gly-psdap
3239:tolhs-24thiaz-gly-betahdbph
3240:ibhs-nme35pyr-gly-psdap
3241:bhs-25thiaz-leu-betameph
3242:bhs-25thiaz-bala-betafphe
3243:ibhs-oxadiaz-gly-beta34meoph
3244:phhs-me24oxaz-ala-zdap
3245:ibhs-ithiadiaz-gly-betabpy
3246:bhs-ithiadiaz-gly-betamethi
3247:phhs-25thiaz-bala-csdap
3248:bhs-25thiaz-met-betadcph
3249:2py-nme35pyr-bala-psdap
3250:bhs-25thiaz-gly-betatos
3251:bhs-25oxaz-gly-betaomebendi
3252:bhs-24thiaz-gly-betapyee
3253:ibhs-oxadiaz-bala-betafphe
3254:gua-24thiaz-nmgly-betapy

CA 02371604 2001-10-24
WO 00!66618 PCTIEPOOl03469
- 114 -
3255:ibhs-24thiaz-bala-psdapee
3256:2py-25methiaz-bala-aspaba
3257:ibhs-25thiaz-gly-betabediox
3258:phhs-me24thiaz-leu-beta34meoph
3259:ibhs-25methiaz-bala-betabthioph
3260:ibhs-25oxaz-gly-betapych
3261:2py-52thiaz-ala-betainyl
3262:tolhs-me24thioph-ala-zdap
3263:ibhs-24thioph-gly-betabmph
3264:bhs-25thiaz-gly-zdaptb
3265:phhs-24thioph-bala-ibsdap
3266:bhs-nme35pyr-gly-betahni
3267:bhs-25oxaz-gly-zdapch
3268:phhs-25oxaz-gly-betafu3
3269:phhs-25thiaz-bala-betadmoph
3270:bhs-oxadiaz-nmgly-betadmoph
3271:bhs-25methiaz-gly-betahbcph
3272:tolhs-25methiaz-bala-betabthioph
3273:bhs-oxadiaz-bala-zdapch
3274:gua-24oxaz-gly-betaamibe
3275:phhs-25thiaz-gly-betabpy
3276:bhs-24im-bala-psdap
3277:phhs-24thiaz-bala-asppha
3278:ibhs-ithiadiaz-gly-betadmoph
3279:tolhs-24thioph-bala-suabu
3280:bim-me24oxaz-bala-betadcph
3281:tolhs-oxadiaz-bala-betabph
3282:phhs-24thiaz-bala-betaipro
3283:bhs-oxadiaz-bala-betaipro
3284:phhs-25oxaz-bala-betadtrif
3285:ibhs-25oxaz-gly-betambiph
3286:bhs-nme35pyr-gly-aspibua
3287;bim-oxadiaz-leu-betapy
3288:bhs-oxadiaz-ala-betaanaphth
3289:2py-25thiaz-ala-betainyl
3290:2py-24thiaz-bala-suabu
3291:bhs-24thiaz-bala-betahni

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-115
3292:bhs-25methiaz-ser-betapy
3293:phhs-oxadiaz-gly-betaheph
3294.gua-24thiaz-gly-suabu
3295:tolhs-25methiaz-bala-betacph
3296:ibhs-25thiaz-gly-betapy
3297:ibhs-24thioph-bala-betatos
3298:thpym-24thiaz-gly-betahdcph
3299:tolhs-25methiaz-bala-aspibua
3300:thazep-25oxaz-gly-psdap
3301:tolhs-nme35pyr-bala-zdapch
3302:bhs-oxadiaz-gly-betaphethioa
3303:phhs-me24thioph-leu-betaph
3304:phhs-me25oxaz-gly-psdap
3305:tolhs-25methiaz-gly-betamethi
3306:ibhs-25oxaz-bala-betacbph
3307:bhs-25thiaz-leu-betapy
3308:ibhs-ithiadiaz-gly-betahdcph
3309:they-24oxaz-gly-betadcph
3310:phhs-25thiaz-bala-betathioph
3311:bim-ithiadiaz-gly-aspaba
3312:tolhs-ithiadiaz-bala-aspbzla
3313:bim-24thioph-ala-zdap
3314:ibhs-25oxaz-gly-betapyr
3315:bhs-24thioph-gly-betaipro
3316:bhs-24thiaz-bala-betaoxope
3317:bhs-nme35pyr-gly-betah35dc
3318:phhs-oxadiaz-bala-betapym
3319:tolhs-24thiaz-bala-betaheph
3320:ibhs-ithiadiaz-gly-betaheph
3321:phhs-24thioph-gly-betaomebendi
3322:ibhs-ithiadiaz-bala-betacthioph
3323:bhs-ithiadiaz-gly-betamesu
3324:nmhs-24thioph-gly-betadcph
3325:ibhs-24thiaz-bala-betatrif
3326:bhs-oxadiaz-bala-betambiph
3327:bhs-oxadiaz-nmgly-betaipro
3328:bim-me24thioph-leu-beta34meoph

CA 02371604 2001-10-24
WO 00!66618 PCTlEP00/03469
- 116 -
3329:2pmhs-24thiaz-gly-betahbcph
3330:tolhs-24thiaz-gly-betapy
3331:ibhs-25oxaz-bala-betathiobe
3332:2pmhs-42pym-gly-betapy
3333:phhs-25methiaz-bala-betaph
3334:phhs-oxadiaz-gly-betafphe
3335:tolhs-ithiadiaz-gly-betahmo
3336:bhs-25oxaz-nmgly-betathioph
3337;bhs-42nmeim-gly-suabu
3338:ibhs-24thiaz-bala-betah35dc
3339;bgua-24thioph-gly-betameph
3340:phhs-ithiadiaz-gly-betatos
3341:tolhs-oxadiaz-giy-beta34dcph
3342:ibhs-25methiaz-bala-betaheph
3343:bim-25fur-ala-zdap
3344:bim-24thioph-bala-betadcph
3345:ibhs-25oxaz-bala-betaftrif
3346:ibhs-oxadiaz-gly-beta34dcph
3347:tolhs-25thiaz-gly-betamesu
3348:bhs-oxadiaz-bala-betapy
3349:impy-24thioph-bala-betaphethioa
3350:ibhs-24thioph-giy-betadcph
3351:bhs-ithiadiaz-gly-aspibua
3352:bhs-24oxaz-bala-zdap
3353:tolhs-25thiaz-gly-betapytb
3354:phhs-oxadiaz-bala-betabenfu
3355:tolhs-24thiaz-bala-betahcbph
3356:bim-25thiaz-bala-betacph
3357:ibhs-25methiaz-bala-betatbuph
3358:tolhs-25thiaz-bala-betabthioph
3359:phhs-ithiadiaz-bala-betathio3
3360:ibhs-24thioph-bala-busu2be
3361:2py-53pyrazo-ala-betadcph
3362:tolhs-oxadiaz-gly-beta35dbph
3363:ibhs-ithiadiaz-bala-betahc
3364:phhs-oxadiaz-bala-betapytb
3365:phhs-oxadiaz-gly-betafbph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 117
3366: tolhs-me24oxaz-gly-betadcph
3367: bhs-25oxaz-bala-betapytb
3368: phhs-24thiaz-gly-betahdbph
3369: bim-26py-ala-betainyl
3370: phhs-24thioph-gly-betambiph
3371: bhs-nme35pyr-gly-betambiph
3372: bhs-ithiadiaz-bala-betamesu
3373: tolhs-nme35pyr-giy-psdapch
3374: bhs-25oxaz-nmgly-betabpy
3375: tolhs-me24thioph-ala-betapy
3376: phhs-24thiaz-gly-betameph
3377: phhs-25oxaz-giy-betaol
3378: bim-24thioph-bala-betahc
3379: bhs-nme35pyr-ala-betabpy
3380: ibhs-24thiaz-gly-betadhbfu
3381: bhs-25oxaz-gly-betahbcph
3382: tolhs-me24oxaz-leu-betaph
3383: 4pmhs-26py-gly-betapy
3384: ibhs-25thiaz-bala-betahbcph
3385: tolhs-24thiaz-bala-betadcph
3386: tolhs-oxadiaz-bala-betainyl
3387: tolhs-25methiaz-bala-psdap
3388: phhs-me24thioph-bala-betadcph
3389: phhs-oxadiaz-bala-betathio3
3390: phhs-24thioph-bala-asppha
3391: bhs-24thioph-bala-betainyl
3392: bhs-25oxaz-gly-betatluo
3393: ibhs-nme35pyr-bala-psdapee
3394: bim-me25oxaz-leu-betadcph
3395: tolhs-ithiadiaz-bala-betafu2
3396: phhs-25methiaz-gly-betabthioph
3397: bhs-24thiaz-bala-betafbph
3398: ibhs-nme35pyr-bala-betafluo
3399: bhs-ithiadiaz-nmgly-betal3bendi
3400: bhs-24thiaz-gly-betaol
3401: ibhs-oxadiaz-gly-suabu
3402: nmhs-42nmeim-gly-psdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 118 -
3403:phhs-25methiaz-bala-asppha
3404:gua-26py-gly-beta34dcph
3405:phhs-ithiadiaz-bala-betadbph
3406:phhs-me25thioph-gly-psdap
3407:bhs-24thiaz-bala-betabediox
3408:bim-25thioph-ala-betadcph
3409:bhs-ithiadiaz-ala-ibsdap
3410:ibhs-25thiaz-bala-aspibua
3411:bhs-24thioph-bala-beta4bph
3412:ibhs-ithiadiaz-bala-betabnaphth
3413:2py-25methiaz-gly-betathio3
3414:bhs-ithiadiaz-gly-betampy
3415:phhs-nme35pyr-gly-betamethi
3416:ibhs-24thioph-bala-beta34meoph
3417:ibhs-25oxaz-bala-betafu3
3418:phhs-ithiadiaz-gly-betaimid
3419:tolhs-25oxaz-gly-betadcphch
3420:tolhs-24thioph-bala-betafbph
3421:ibhs-25thiaz-bala-betatbuph
3422:bhs-25oxaz-gly-psdaptb
3423:bim-me24thioph-bala-betaph
3424:bhs-24thiaz-gly-beta3quin
3425:bim-me24thiaz-leu-betadcph
3426:phhs-ithiadiaz-gly-beta13bendi
3427:tolhs-25methiaz-giy-aspibua
3428:tolhs-24thiaz-gly-betadhbfu
3429:bhs-42pym-ala-betadcph
3430:ibhs-nme35pyr-bala-betacthoph
3431:bhs-25oxaz-gly-betaanaphth
3432:ibhs-ithiadiaz-gly-betatos
3433:ibhs-nme35pyr-bala-betadcph
3434:ibhs-nme35pyr-bala-betatos
3435:tolhs-nme35pyr-bala-betahbcph
3436:2py-me25thioph-ala-betaph
3437:ibhs-oxadiaz-gly-busu2be
3438:bim-triaz-bala-zdap
3439:bhs-24thioph-gly-betampy

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 119 -
3440:bhs-35fur-bala-betapy
3441:bhs-me24thioph-leu-beta34meoph
3442:ibhs-25oxaz-bala-betaanaphth
3443:bhs-25oxaz-leu-zdap
3444:gua-24thiaz-gly-betadmoph
3445:bhs-ithiadiaz-bala-betacthioph
3446:bhs-25thiaz-gly-betapyr
3447:ibhs-ithiadiaz-gly-beta34dcph
3448:tolhs-oxadiaz-bala-betaheph
3449:tolhs-oxadiaz-gly-betapyee
3450:gua-24oxaz-gly-betambiph
3451:tolhs-24thioph-gly-betafu3
3452:tolhs-24thiaz-bala-zdaptb
3453:tolhs-ithiadiaz-gly-betaoxope
3454:phhs-nme35pyr-gly-betaftrif
3455:bhs-ithiadiaz-bala-betadcphtb
3456:bim-triaz-bala-psdap
3457:bhs-nme35pyr-gly-betapyr
3458:bhs-25oxaz-bala-betaipro
3459:tolhs-nme35pyr-gly-betabmph
3460:ibhs-24thiaz-bala-betadmph
3461:tolhs-24thiaz-gly-betaphethio
3462:agua-26py-gly-betadcph
3463:2py-triaz-gly-psdap
3464:2py-24thiaz-bala-betabnaphth
3465;tolhs-oxadiaz-bala-betaph
3466:ibhs-25methiaz-gly-aspaba
3467:bim-me24thiaz-gly-betaph
3468:bim-me24thioph-ala-betapy
3469:ibhs-24thiaz-bala-betaanaphth
3470:bim-42nmeim-ala-betapy
3471:ibhs-24thioph-bala-betahni
3472:bhs-24thioph-bala-asppha
3473:ibhs-24thiaz-bala-betahph
3474:bhs-25oxaz-bala-betahc
3475:tolhs-24thioph-gly-betah35dc
3476:bim-me24thioph-ala-beta34meoph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00/03469
- 120 -
3477:bim-me25oxaz-bala-beta34meoph
3478:tolhs-25thiaz-bala-aspaba
3479:ibhs-oxadiaz-bala-betampy
3480:bhs-35thioph-ala-betapy
3481:tolhs-24thioph-bala-betafph
3482:bhs-nme35pyr-bala-ibsdap
3483:2pmhs-24thioph-bala-betapyr
3484:phhs-24thiaz-gly-betafphe
3485:bhs-25oxaz-bala-betacbph
3486:tolhs-24thioph-gly-zdaptb
3487:bim-me24thiaz-leu-betapy
3488:bim-ithiadiaz-leu-betapy
3489:ibhs-ithiadiaz-bala-beta34dcph
3490:bhs-oxadiaz-bala-csdap
3491:phhs-25methiaz-bala-aspbzla
3492:2py-me24oxaz-gly-psdap
3493:bhs-24thioph-gly-csdap
3494:phhs-ithiadiaz-bala-betadcphch
3495:ibhs-nme35pyr-gly-asppha
3496:bhs-oxadiaz-gly-betaftrif
3497:bhs-25methiaz-bala-betabenfu
3498:gua-24thiaz-gly-betaomebendi
3499:bhs-me25thiaz-gly-beta34meoph
3500:bim-25methiaz-bala-betampy
3501:phhs-25oxaz-gly-betaphethio
3502:tolhs-24thiaz-gly-zdap
3503:bhs-nme35pyr-bala-betacph
3504:tolhs-nme35pyr-gly-betabdimo
3505:bhs-nme35pyr-bala-betadcphch
3506:bhs-25thiaz-bala-betabnaphth
3507:bhs-25thiaz-bala-betaph
3508:tolhs-oxadiaz-gly-betatrif
3509:2py-me24oxaz-leu-beta34meoph
3510:tolhs-ithiadiaz-bala-betathiome
3511:tolhs-25thiaz-bala-betapych
3512:tolhs-25oxaz-gly-betabediox
3513:tolhs-25methiaz-bala-betapym

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 121 -
3514:bhs-25thiaz-gly-betambiph
3515:phhs-ithiodiaz-bala-betaoxaz
3516:2py-42oxaz-bala-betadcph
3517:bhs-nme35pyr-gly-psdapee
3518:gua-24oxaz-gly-betafph
3519:phhs-24thioph-bala-betafphe
3520:bhs-25thiaz-bala-betapytb
3521:phhs-24thiaz-bala-betadcphch
3522:phhs-25thiaz-bala-betapyr
103523:tolhs-nme35pyr-gly-psdaptb
3524:tolhs-nme35pyr-bala-suabu
3525:bhs-42oxaz-bala-betadcph
3526:phhs-25methiaz-gly-betapych
3527:impy-25methiaz-bala-betainyl
153528:phhs-25thiaz-gly-ibsdap
3529:phhs-25oxaz-gly-betabnaphth
3530:bhs-oxadiaz-gly-betatos
3531:tolhs-25thiaz-gly-betambiph
3532:bhs-25methiaz-bala-psdaptb
203533:impy-24thiaz-gly-betathiobe
3534:bhs-25methiaz-bala-betamethioph
3535:bhs-25thiaz-nmgly-betainyl
3536:bhs-ithiadiaz-bala-betadito
3537:gua-24thiaz-gly-betabenfu
253538:ibhs-24thiaz-bala-betadtrif
3539:phhs-me25thioph-leu-betapy
3540:phhs-me25thiaz-gly-betaph
3541:ibhs-ithiadiaz-gly-betabnaphth
3542:ibhs-25oxaz-gly-betahbcph
303543:bhs-25thiaz-nmgly-beta3quin
3544:impy-24thioph-gly-betahmofu
3545:bhs-24thioph-gly-betapym
3546:2py-52thiaz-gly-zdap
3547:phhs-oxadiaz-bala-betaibph
353548:2pmhs-25methiaz-bala-beta4bph
3549:tolhs-25methiaz-gly-betaet
3550:bhs-25thiaz-ala-betahmph

CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
- 122 -
3551: bhs-25thioph-leu-betapy
3552: bhs-25methiaz-gly-suabu
3553: phhs-oxadiaz-bala-suabu
3554: phhs-25thiaz-bala-psdap
3555: phhs-me24thioph-leu-psdap
3556: bim-24thioph-gly-betaibph
3557: ibhs-oxadiaz-gly-betapy
3558: tolhs-24thiaz-bala-betaanaphth
3559: phhs-oxadiaz-bala-betaoxope
103560: bhs-24thiaz-bala-betapyee
3561: ibhs-24thiaz-gly-betahb
3562: tolhs-oxadiaz-bala-betahdbph
3563: bhs-24thiaz-gly-betabph
3564: bhs-ithiadiaz-ala-beta34dcph
153565: ibhs-24thiaz-bala-betatbuph
3566: ibhs-24thiaz-gly-betaipro
3567: bhs-ithiadiaz-ala-betadcph
3568: bhs-25thiaz-bala-betafbph
3569: phhs-25oxaz-gly-zdapch
203570: ibhs-24thiaz-gly-betabediox
3571: ibhs-25methiaz-gly-betadmoph
3572: phhs-24thioph-gly-betaipr
3573: bhs-ithiadiaz-bala-betabph
3574: tolhs-nme35pyr-gly-psdapee
253575: bim-42oxaz-bala-psdap
3576: ibhs-25oxaz-bala-betafluo
3577: tolhs-nme35pyr-gly-betahmo
3578: bhs-25methiaz-bala-aspaba
3579: bhs-25thioph-gly-zdap
303580: phhs-25oxaz-gly-betadmph
3581: bhs-oxadiaz-bala-betapyr
3582: gua-26py-gly-betamethioph
3583: 2py-25thioph-bala-betapy
3584: bhs-oxadiaz-ala-betathioph
353585: bim-thiadiaz-bala-zdap
3586: bim-25oxaz-bala-betamethioph
3587: bhs-25methiaz-nmgly-betamesu

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-123-
3588:dhpyrr-26py-gly-betadcph
3589:2py-me25thiaz-gly-beta34rneoph
3590:phhs-oxadiaz-giy-betahcbph
3591:2py-me25thioph-gly-beta34meoph
3592:phhs-25methiaz-gly-betaibph
3593:ibhs-nme35pyr-bala-betamesu
3594:ibhs-24thioph-bala-betabpy
3595:ibhs-24thioph-bala-betadcphee
3596:ibhs-oxadiaz-gly-betacthioph
3597:gua-24oxaz-gly-betathiome
3598:gua-42pym-gly-betaoxope
3599:2py-25oxaz-gly-aspbzla
3600:bhs-oxadiaz-gly-betadhbfu
3601:phhs-25methiaz-bala-betacthioph
3602:bim-25methiaz-bala-betaipro
3603:jbhs-ithiadiaz-gly-betadito
3604:tolhs-nme35pyr-bala-betahdbph
3605:bim-me24thioph-gly-beta34meoph
3606:phhs-me24thioph-gly-betapy
3607:bhs-35fur-leu-psdap
3608:ibhs-24thiaz-gly-betadmph
3609:dhim-24thiaz-gly-betainyl
3610:bhs-42oxaz-gly-betadcph
3611:ibhs-24thiaz-bala-betaet
3612:phhs-nme35pyr-gly-betahb
3613:gua-24thiaz-gly-betabpy
3614:2py-52thiaz-gly-psdap
3615:tolhs-25methiaz-bala-suabu
3616:phhs-25oxaz-gly-betabdimo
3617:bhs-nme35pyr-nmgly-betadmph
3618:ibhs-oxadiaz-gly-betadmoph
3619:phhs-nme35pyr-gly-aspaba
3620:phhs-nme35pyr-bala-betamesu
3621:bhs-25thiaz-bala-betathiobe
3622:bhs-24thiaz-leu-psdap
3623:bhs-25thiaz-gly-betadtrif
3624:ibhs-25methiaz-gly-betapyee

CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-124
3625: bim-35thioph-gly-psdap
3626: bhs-25oxaz-gly-betadtrif
3627: bhs-oxadiaz-bala-betadcph
3628: bim-25thiaz-ala-betapy
3629: 2py-24thiaz-gly-asppha
3630: bhs-oxadiaz-gly-betaamibe
3631: bhs-ithiadiaz-nmgly-beta34dcpth
3632: bim-24thiaz-gly-betameph
3633: phhs-me24oxaz-gly-psdap
3634:bim-me24thiaz-gly-psdap
3635: bhs-oxadiaz-gly-betaheph
3636: thpy-24thioph-gly-betadcph
3637: gua-25thioph-gly-betaoxope
3638: bhs-42pym-gly-betameph
3639:bhs-24thiaz-gly-betafu2
3640: tolhs-25oxaz-gly-betaheph
3641: bhs-25oxaz-nmgly-betahmph
3642: impy-25oxaz-gly-betapym
3643: gua-25thiaz-gly-betamethi
3644:phhs-oxadiaz-bala-betacthioph
3645: bhs-24thioph-gly-betaibph
3646: phhs-25methiaz-bala-betahmofu
3647: bhs-25oxaz-gly-betacthioph
3648: bhs-oxadiaz-bala-betaipr
3649:phhs-24thioph-gly-betaamibe
3650: phhs-nme35pyr-gly-betaamibe
3651: phhs-25methiaz-gly-betaphethio
3652: phhs-25thiaz-gly-betapbiph
3653: ibhs-25oxaz-gly-betapy
3654:tolhs-nme35pyr-gly-aspibua
3655: ibhs-24thiaz-gly-psdapch
3656: 2py-35fur-ala-psdap
3657: tolhs-24thiaz-bala-betaomebendi
3658: ibhs-25methiaz-bala-betadhbfu
3659:ibhs-25methiaz-bala-betaoxaz
3660: bim-25methiaz-gly-asppha
3661: phhs-ithiadiaz-bala-betadmoph

CA 02371604 2001-10-24
WO 0016661$ PCTIEP00103469
-125-
3662:bhs-35fur-ala-betadcph
3663:phhs-25thiaz-bala-betatos
3664:bim-42nmeim-gly-betafu3
3665:bhs-24thioph-gly-beta35dbph
3666:ibhs-nme35pyr-bala-betadhbfu
3667:cima-24thiaz-bala-psdap
3668:tolhs-25methiaz-bala-betaol
3669:gua-26py-gly-betaipr
3670:tolhs-ithiadiaz-bala-betaipr
103671:ibhs-nme35pyr-gly-csdap
3672:tolhs-24thiaz-gly-betafph
3673:phhs-25methiaz-bala-betaphethio
3674:phhs-ithiadiaz-bala-betafphe
3675:tolhs-24thioph-bala-beta23meoph
153676:phhs-25thiaz-bala-aspbzla
3677:tolhs-oxadiaz-gly-betacbph
3678:bhs-24thiaz-ala-betabnaphth
3679:phhs-25methiaz-bala-betapbiph
3680:2py-24im-ala-psdap
203681:tolhs-24thiaz-bala-betathiobe
3682:pbhs-oxadiaz-giy-betaphethio
3683:tolhs-25oxaz-gly-betahbcph
3684:tolhs-oxadiaz-bala-betacbph
3685:tolhs-25oxaz-gly-beta34meoph
253686:bhs-25oxaz-gly-betathiome
3687:dhim-42nmeim-gly-zdap
3688:ibhs-ithiadiaz-gly-betabthioph
3689:ibhs-oxadiaz-gly-betaet
3690:bhs-25methiaz-nmgly-beta34dcph
303691:ibhs-25oxaz-gly-beta23meoph
3692:phhs-25methiaz-gly-betacph
3693:ibhs-nme35pyr-gly-betathio3
3694:bim-me24thiaz-gly-betadcph
3695:phhs-24thioph-gly-csdap
353696:ibhs-nme35pyr-bala-asppha
3697:2py-me24thioph-ala-psdap
3698:tolhs-25oxaz-gly-zdapee

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 126
3699: dhim-26py-gly-psdap
3700: 2py-25thioph-bala-zdap
3701: tolhs-25oxaz-bala-psdapch
3702: phhs-24thioph-gly-zdapch
3703: bim-thiadiaz-bala-betadcph
3704: bim-24oxaz-bala-betadcph
3705: tolhs-25oxaz-gly-psdap
3706: bim-52thiaz-gly-zdap
3707: ibhs-oxadiaz-baia-betadito
103708: bhs-me24thiaz-bala-zdap
3709: 2py-ithiadiaz-bala-asppha
3710: gua-42pym-gly-betafu2
3711: phhs-25methiaz-bala-betaanaphth
3712: bhs-26py-ala-zdap
153713: ibhs-24thiaz-gly-betaoxope
3714: phhs-24thioph-bala-betadcphee
3715: dhim-52thiaz-ala-betainyl
3716: phhs-ithiadiaz-bala-betaanaphth
3717: bhs-24thioph-gly-betafph
203718: gua-24thiaz-gly-betahb
3719: bhs-oxadiaz-gly-betaipro
3720: phhs-25methiaz-gly-betatrif
3721: bim-me24thioph-gly-zdap
3722: ibhs-oxadiaz-bala-betaoxaz
253723: gua-24thiaz-gly-betacbph
3724: ibhs-ithiadiaz-gly-betahni
3725: bim-ithiadiaz-bala-aspibua
3726: 2py-42oxaz-gly-betadcph
3727: tolhs-ithiadiaz-gly-betaet
303728: ibhs-25methiaz-bala-betahdcph
3729: 2py-42nmeim-gly-betacph
3730: tolhs-oxadiaz-bala-betaanaphth
3731: phhs-ithiadiaz-gly-betaanaphth
3732: phhs-ithiadiaz-gly-betafluo
353733: tolhs-ithiadiaz-bala-betaftrif
3734: phhs-oxadiaz-gly-betaet
3735: phhs-24thiaz-bala-csdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 127
3736: ibhs-25oxaz-bala-psdap
3737: 2pmhs-25oxaz-gly-betaol
3738: tolhs-oxadiaz-gly-betadcph
3739: phhs-24thioph-bala-betamesu
3740: bhs-25thiaz-gly-betadito
3741: 2py-42pym-ala-betainyl
3742: tolhs-me25oxaz-gly-zdap
3743: 2pmhs-25oxaz-gly-beta3quin
3744: phhs-24thiaz-bala-betahmo
103745: tolhs-24thiaz-bala-csdap
3746: bhs-26py-gly-betapy
3747: bim-53pyrazo-leu-betapy
3748: 2py-25methiaz-gly-zdap
3749: ibhs-nme35pyr-gly-betadtrif
153750: dhim-42pym-ala-betadcph
3751: ibhs-nme35pyr-bala-zdaptb
3752: bim-25thiaz-gly-betadbph
3753: tolhs-25oxaz-bala-betahrnph
3754: tolhs-25methiaz-bala-betahph
203755: ibhs-ithiadiaz-gly-betapyr
3756: bhs-ithiadiaz-ala-betaipro
3757: ibhs-25methiaz-bala-psdapch
3758: phhs-nme35pyr-bala-zdapee
3759: bim-me25thiaz-bala-beta34meoph
253760: tolhs-oxadiaz-bala-betahdcph
3761: phhs-oxadiaz-gly-betampy
3762: ibhs-oxadiaz-gly-betathiome
3763: impy-2thioph-gly-betapy
3764: bhs-25oxaz-gly-betainyl
303765: ibhs-25thiaz-bala-betafph
3766: tolhs-ithiadiaz-gly-betafphe
3767: hts-42pym-gfy-betapy
3768: ibhs-24thiaz-gly-betahmph
3769: phhs-nme35pyr-bala-betapyee
353770: tolhs-nme35pyr-gly-beta34meoph
3771: bim-me25thioph-bala-betaph
3772: tolhs-24thiaz-bala-betadmph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 128
3773:bhs-ithiadiaz-gly-betaamibe
3774:bhs-25thioph-leu-psdap
3775:bhs-me25thiaz-leu-betaph
3776:bhs-25methiaz-bala-csdap
3777:tolhs-25thiaz-gly-beta4bph
3778:bhs-24thioph-nmgly-betainyl
3779:phhs-oxadiaz-gly-betabenfu
3780:phhs-nme35pyr-gly-psdaptb
3781:gua-24thiaz-gly-betatos
3782:tolhs-oxadiaz-gly-betabdimo
3783:bhs-25thiaz-gly-betafluo
3784:bhs-triaz-ala-psdap
3785:bhs-35pyrazo-gly-betapy
3786:2pmhs-24thiaz-bala-betapyr
3787:tolhs-25methiaz-bala-betaphethioa
3788:bhs-24thiaz-bala-betahdbph
3789:ibhs-25thiaz-gly-betadcphee
3790:phhs-24thioph-bala-betadito
3791:phhs-oxadiaz-gly-betabdimo
3792:2py-24thiazme-gly-betapy
3793:ibhs-nme35pyr-gly-beta34meoph
3794:phhs-ithiadiaz-gly-betahbcph
3795:ibhs-oxadiaz-gly-betaibph
3796:2py-24thioph-bala-psdap
3797:2pmhs-25oxaz-bala-suabu
3798:bhs-24thioph-nmgly-betabpy
3799:ibhs-oxadiaz-bala-asppha
3800:gua-25thiaz-gly-betaomebendi
3801:3pmhs-42pym-gfy-betapy
3802:tolhs-25thiaz-gly-suabu
3803:ibhs-24thioph-bala-betafu2
3804:tolhs-oxadiaz-bala-psdapch
3805:ibhs-oxadiaz-bala-betadcphtb
3806:phhs-ithiadiaz-bala-betaftrif
3807:ibhs-oxadiaz-gly-betaoxope
3808:2py-oxadiaz-bala-psdap
3809:tolhs-me25oxaz-gly-psdap

CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-129-
3810:bhs-25methiaz-nmgly-beta13bendi
3811:tolhs-24thiaz-bala-betabpy
3812:hs-42pym-gly-betapy
3813:tolhs-25oxaz-bala-betapbiph
3814:ibhs-oxadiaz-bala-beta34meoph
3815:bhs-ithiadiaz-ala-betameph
3816:phhs-me24oxaz-leu-beta34meoph
3817:bhs-25thiaz-nmgly-betafphe
3818:tolhs-ithiadiaz-gly-betafluo
103819:tolhs-25thiaz-bala-betamethi
3820:bhs-24thioph-nmgly-betathio3
3821:bhs-24thiaz-hphe-betapy
3822:tolhs-25methiaz-bala-aspbzla
3823:bim-me25thiaz-ala-betadcph
153824:bhs-25thiaz-bala-asppha
3825:bhs-nme35pyr-gly-betamesu
3826:ibhs-ithiadiaz-gly-betapyee
3827:phhs-25oxaz-bala-betabnaphth
3828:ibhs-24thioph-gly-betadmoph
203829:phhs-ithiadiaz-gly-betabnaphth
3830:tolhs-nme35pyr-gly-beta3quin
3831:bhs-me25thioph-bala-betapy
3832:tolhs-nme35pyr-bala-betapym
3833:bhs-nme35pyr-ala-beta3quin
253834:ibhs-25oxaz-gly-betamethioph
3835:tolhs-25thiaz-gly-betaoxaz
3836:phhs-ithiadiaz-bala-betadcphee
3837:tolhs-24thiaz-bala-betaphethioa
3838:2py-25oxaz-gly-betadcph
303839:tolhs-oxadiaz-bala-betampy
3840:2py-42oxaz-leu-betapy
3841:ibhs-24thiaz-gly-zdaptb
3842:phhs-ithiadiaz-bala-psdaptb
3843:phhs-nme35pyr-gly-betafluo
353844:bhs-nme35pyr-gly-zdapee
3845:ibhs-24thioph-bala-betaoxaz
3846:ibhs-24thiaz-bala-betaoxaz

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 130
3847: thazep-25thiaz-gly-beta13bendi
3848: bhs-24thioph-ala-betabnaphth
3849: bhs-ithiadiaz-nmgly-betamesu
3850: phhs-oxadiaz-giy-betacph
3851: ibhs-25methiaz-bala-betapyr
3852: 2py-25methiaz-gly-betaol
3853: tolhs-25methiaz-gly-betahbcph
3854: ibhs-25thiaz-bala-betadmph
3855: phhs-25thiaz-gly-beta35dbph
3856:ibhs-25thiaz-gly-csdap
3857: phhs-25thiaz-gly-betamethioph
3858: 2py-24thiaz-gly-betathio3
3859; ibhs-ithiadiaz-bala-betahni
3860: gua-25thioph-gly-betathio3
3861:bhs-oxadiaz-gly-beta34dcph
3862: dhim-25thiophme-ala-betameph
3863: ibhs-nme35pyr-bala-betahdcph
3864: tolhs-nme35pyr-bala-betathio3
3865: bhs-24thioph-gly-betacthioph
3866:phhs-25thiaz-bala-betaol
3867: ibhs-24thiaz-gly-ibsdap
3868: bhs-me24im-gly-betameph
3869: tolhs-24thiaz-giy-betabnaphth
3870: tolhs-me25thiaz-bala-zdap
3871:2py-35fur-bala-zdap
3872; tolhs-oxadiaz-bala-betabthioph
3873: bhs-ithiadiaz-gly-betahph
3874: bgua-25methiaz-gly-betameph
3875: phhs-ithiadiaz-bala-betabediox
3876:phhs-25methiaz-bala-betadcph
3877: ibhs-nme35pyr-gly-betapbiph
3878: tolhs-25methiaz-gly-betabenfu
3879: bim-25thiaz-bala-psdap
3880: bhs-25methiaz-gly-betaet
3881:phhs-me25thioph-bala-psdap
3882: tolhs-25thiaz-gly-betaoxope
3883: toihs-ithiadiaz-gly-betafu2

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 131 -
3884:ibhs-oxadiaz-bala-betabpy
3885:bim-25methiaz-gly-aspaba
3886:ibhs-nme35pyr-bala-betaamibe
3887:bhs-25methiaz-bala-betainyl
3888:bhs-ithiadiaz-gly-psdapee
3889:bgua-25oxaz-bala-betapy
3890:phhs-25methiaz-gly-betamesu
3891:phhs-25methiaz-bala-betaftrif
3892:ibhs-25thiaz-bala-betaanaphth
3893:ibhs-oxadiaz-bala-beta3quin
3894:phhs-25methiaz-bala-zdapch
3895:phhs-nme35pyr-bala-ibsdap
3896:2pmhs-25methiaz-bala-betathioph
3897:bhs-me24thiaz-leu-betapy
3898:phhs-25thiaz-bala-betathiome
3899:tolhs-25thiaz-gly-betapbiph
3900:gua-25thioph-gly-betahmo
3901:bim-25thioph-bala-betapy
3902:tolhs-oxadiaz-bala-beta35dbph
3903:tolhs-ithiadiaz-gly-aspbzla
3904:tolhs-nme35pyr-bala-betacthioph
3905:bhs-triaz-gly-psdap
3906:ibhs-oxadiaz-bala-betadhbfu
3907:phhs-me25oxaz-leu-zdap
3908:tolhs-oxadiaz-gly-betamethioph
3909:bhs-25oxaz-bala-betadbph
3910:bhs-oxadiaz-bala-betameph
3911:phhs-24thiaz-gly-aspaba
3912:bim-25thiaz-bala-betaimid
3913:2py-24thioph-leu-betadcph
3914:ibhs-25oxaz-gly-betaanaphth
3915:ibhs-nme35pyr-gly-betapyr
3916:tolhs-24thioph-gly-beta35dbph
3917:2pmhs-25methiaz-bala-betapyr
3918:tolhs-25thiaz-gly-betadmph
3919:2py-25methiaz-leu-betapy
3920:bhs-oxadiaz-bala-asppha

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 132 -
3921:bhs-25oxaz-gly-betahb
3922:tolhs-24thioph-bala-betameph
3923:phhs-me25oxaz-leu-beta34meoph
3924:2py-42nmeim-bala-betapy
3925:phhs-me25thiaz-ala-betapy
3926:phhs-25methiaz-bala-betampy
3927:ibhs-25oxaz-bala-suabu
3928:bhs-oxadiaz-gly-betabmph
3929:bhs-25oxaz-bala-betambiph
3930:tolhs-nme35pyr-gly-aspbzla
3931:ibhs-nme35pyr-gly-betapych
3932:ibhs-24thiaz-gly-betaph
3933:bhs-24thiaz-bala-betacthioph
3934:bhs-me25oxaz-leu-beta34meoph
3935:bhs-25oxaz-bala-betahbcph
3936:tolhs-25oxaz-bala-betafbph
3937:tolhs-25methiaz-bala-betabmph
3938:bhs-nme35pyr-nmgly-betadhbfu
3939:phhs-25methiaz-bala-betahni
3940:bhs-24thioph-bala-beta34meoph
3941:2py-24thioph-gly-betadito
3942:bhs-25oxaz-gly-betahph
3943:bhs-25methiaz-gly-psdaptb
3944:ibhs-nme35pyr-gly-betapym
3945:ibhs-ithiadiaz-gly-betadmph
3946:bim-24im-leu-zdap
3947:impy-25thiaz-gly-beta34meoph
3948:ur-42pym-ala-psdap
3949:bhs-ithiadiaz-bala-betafbph
3950:bhs-24thiaz-gly-betatos
3951:ibhs-24thioph-gly-zdapee
3952:tolhs-25methiaz-bala-betadcphtb
3953:ibhs-ithiadiaz-bala-betahmo
3954:ibhs-nme35pyr-bala-betahb
3955:phhs-25oxaz-gly-betaet
3956:ibhs-24thiaz-gly-betathio3
3957:bhs-25methiaz-gly-betahmph

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 133 -
3958:bhs-42oxaz-ala-psdap
3959:gua-25thiaz-gly-betapy
3960:ibhs-nme35pyr-bala-betahbcph
3961:phhs-nme35pyr-bala-betathiome
3962:bim-25methiaz-bala-psdap
3963:bhs-24thiaz-ala-betadmph
3964:phhs-25methiaz-gly-betathiome
3965:phhs-me25thioph-bala-betadcph
3966:bhs-ithiadiaz-bala-betathiome
3967:bhs-nme35pyr-bala-betathioph
3968:bim-24thioph-bala-betaimid
3969:phhs-24thioph-gly-betaftrif
3970:bhs-25thiaz-gly-betadcph
3971:phhs-me25thioph-gly-betaph
3972:bim-25methiaz-ala-betapy
3973:bhs-24thioph-ala-betathio3
3974:ibhs-24thiaz-bala-aspbzla
3975:phhs-oxadiaz-bala-betahmph
3976:bhs-ithiadiaz-ala-betaanaphth
3977:bhs-25oxaz-gly-aspaba
3978:bhs-ithiadiaz-gly-betaol
3979:2py-thiadiaz-leu-betadcph
3980:phhs-me25oxaz-bala-betapy
3981:ibhs-25oxaz-gly-beta34dcph
3982:ibhs-oxadiaz-gly-betabmph
3983:bhs-oxadiaz-bala-beta4bph
3984:tolhs-24thiaz-bala-betafu3
3985:bhs-25oxaz-bala-betafu2
3986:tolhs-me25thiaz-ala-psdap
3987:tolhs-25oxaz-bala-betamesu
3988:2py-26py-gly-betahdcph
3989:bhs-25methiaz-met-betadcph
3990:bhs-me25oxaz-bala-beta34meoph
3991:bim-me24thioph-gly-betaph
3992:bhs-25oxaz-gly-betaibph
3993:phhs-oxadiaz-gly-betahdbph
3994:tolhs-me25oxaz-ala-betadcph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 134 -
3995: 2py-25fur-gly-zdap
3996: bim-thiadiaz-leu-betapy
3997: tolhs-24thiaz-bala-betathioph
3998: 2py-24thioph-gly-betathio3
3999: bhs-24thiaz-gly-betahmo
4000: phhs-nme35pyr-gly-betabenfu
4001: ibhs-25thiaz-bala-betapych
4002: bhs-24oxaz-ala-zdap
4003: impy-24thiaz-bala-betamethi
104004: ibhs-oxadiaz-gly-betaphethio
4005: tolhs-25thiaz-bala-betaet
4006: phhs-25methiaz-bala-betahmph
4007: phhs-oxadiaz-bala-betadito
4008: bim-25fur-ala-betadcph
154009: tolhs-oxadiaz-bala-beta34meoph
4010: bhs-24thioph-ala-betamesu
4011: phhs-25thiaz-gly-betadmoph
4012: bhs-nme35pyr-ala-betaipro
4013: tolhs-25thiaz-gly-betabpy
204014: ibhs-nme35pyr-gly-betaipr
4015: bhs-25methiaz-gly-betabmph
4016: tolhs-25oxaz-bala-betapych
4017: tolhs-oxadiaz-gly-csdap
4018: tolhs-nme35pyr-bala-beta35dbph
254019: 2py-me25thioph-leu-beta34meoph
4020: phhs-oxadiaz-bala-betahni
4021: ibhs-24thioph-bala-betadmph
4022: bhs-25methiaz-gly-betadito
4023: bhs-42nmeim-ala-betadcph
304024: ibhs-25oxaz-bala-betaphethioa
4025: bim-me24thiaz-bala-zdap
4026: bhs-42py-gly-betameph
4027: tolhs-24thioph-gly-betahmph
4028: bim-me24thioph-ala-zdap
354029: bim-me25thiaz-gly-beta34meoph
4030: bhs-25thiaz-bala-betabthioph
4031: bim-25thiaz-gly-aspaba

CA 02371604 2001-10-24
WO 00166618 PCTIEP0010346g
- 135
4032: gua-24thiaz-gly-betafbph
4033: thpym-42pym-gly-betahcbph
4034: bhs-nme35pyr-bala-betaamibe
4035: bhs-25oxaz-gly-betapbiph
4036: phhs-25thiaz-gly-betahc
4037: 2py-nme35pyr-bala-aspibua
4038: bim-24oxaz-gly-betadcph
4039: phhs-24thioph-gly-betahbcph
4040: 2py-me25thioph-leu-betapy
104041: bhs-me25thioph-ala-psdap
4042: bhs-me25oxaz-leu-betapy
4043: tolhs-ithiadiaz-bala-betahmofu
4044: 2py-25th iaz-bala-betabn
aphth
4045: bim-24thiaz-gly-betadmph
154046: ibhs-24thiaz-gly-betaol
4047: tolhs-25thiaz-gly-betafbph
4048: bhs-42nmeim-bala-betapy
4049: phhs-25methiaz-gly-betahb
4050: phhs-25thiaz-bala-betacbph
204051: tolhs-nme35pyr-gly-zdapee
4052: phhs-ithiadiaz-bala-zdaptb
4053: thazep-25thiaz-bala-zdap
4054: 2py-24chin-gly-betapy
4055: ibhs-25methiaz-gly-betapytb
254056: bhs-25thiaz-bala-betadcphtb
4057: phhs-25methiaz-bala-beta13bendi
4058: tolhs-24thiaz-gly-betapbiph
4059: bhs-ithiadiaz-gly-betaipr
4060: 2py-35thioph-gly-zdap
304061: phhs-me25thiaz-gly-zdap
4062: ibhs-24thioph-bala-betadcph
4063: tolhs-25oxaz-gly-betambiph
4064: bhs-nme35pyr-gly-betahmph
4065: bhs-25methiaz-ala-psdap
354066: tolhs-25thiaz-bala-betafph
4067: tolhs-ithiadiaz-gly-betabph
4068: tolhs-nme35pyr-bala-aspaba

CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-136-
4069:2py-42oxaz-ala-zdap
4070:ibhs-nme35pyr-bala-betadcphch
4071:2py-24thiaz-ala-betameph
4072:2py-24thiaz-gly-betaol
4073:ibhs-25methiaz-bala-betapych
4074:2pmhs-24thiaz-gly-betadtrif
4075:dhim-26pyrazi-gly-betameph
4076:tolhs-24thiaz-gly-betadcph
4077:ibhs-nme35pyr-bala-betapym
4078:ibhs-25methiaz-bala-betahb
4079:bhs-24thioph-bala-betadcph
4080:ibhs-oxadiaz-gly-betapyee
4081:bhs-25thiaz-gly-aspibua
4082:bim-me25thiaz-leu-betadcph
4083:phhs-25methiaz-bala-betatos
4084:phhs-me25thiaz-ala-psdap
4085:bhs-25methiaz-ala-ibsdap
4086:bim-52thiaz-ala-betadcph
4087:phhs-24thiaz-bala-betambiph
4088:phhs-ithiadiaz-gly-beta3quin
4089:bhs-24thioph-gly-betapbiph
4090:2py-25oxaz-bala-betaftrif
4091:bhs-oxadiaz-ala-betameph
4092:tolhs-oxadiaz-bala-betaoxaz
4093:ibhs-oxadiaz-bala-betaibph
4094:bhs-24thiaz-gly-betaph
4095:ibhs-nme35pyr-gly-betafbph
4096:tolhs-nme35pyr-gly-betaanaphth
4097:phhs-24thiaz-gly-betamesu
4098:bhs-25oxaz-ala-betadcph
4099:tolhs-ithiadiaz-bala-betaimid
4100:impy-25oxaz-gly-betabph
4101:dhim-42pym-gly-betadtrif
4102:2py-me25thioph-bala-betapy
4103:ibhs-24thioph-gly-betadtrif
4104:2py-me24thioph-bala-beta34meoph
4105:bhs-25thiaz-nmgly-ibsdap

CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-137-
4106: phhs-nme35pyr-bafa-betahmo
4107: phhs-25oxaz-gly-betaheph
4108: gua-42pym-gly-betainyl
4109: gua-42pym-gly-betaomebendi
4110: bhs-25thiaz-bala-betahbcph
4111: tolhs-25oxaz-bala-betabthioph
4112: bhs-nme35pyr-nmgly-betahrnph
4113: ibhs-25oxaz-gly-betadmoph
4114: tolhs-nme35pyr-bala-betabmph
104115: tolhs-nme35pyr-bala-betapbiph
4116: bhs-25oxaz-bafa-betahdcph
4117: impy-24thioph-bala-betamethi
4118: bim-me24oxaz-gly-beta34meoph
4119: phhs-me25oxaz-ala-betapy
154120: bim-me24thioph-gly-psdap
4121: bhs-24thioph-gly-betahph
4122: phhs-24thioph-gly-betaol
4123: ibhs-25thiaz-bala-zdaptb
4124: tolhs-nme35pyr-gly-betaamibe
204125: bhs-24thiaz-bala-betahb
4126: bhs-24thiaz-gly-zdapch
4127: gua-42pym-gly-betapyr
4128: phhs-oxadiaz-gly-zdapee
4129: bim-25thiaz-ala-psdap
254130: bhs-ithiadiaz-gly-betapy
4131: bhs-25methiaz-gly-betacph
4132: ibhs-25oxaz-gly-betaet
4133: 2py-42py-gly-betapy
4134: 2py-25oxaz-gly-betapy
304135: bhs-oxadiaz-gly-betafph
4136: ibhs-24thioph-gly-beta3quin
4137: tolhs-25oxaz-bala-betadcphee
4138: 2py-me25oxaz-ala-psdap
4139: bhs-24thioph-nmgly-betadito
354140: bhs-nme35pyr-gly-betahdcph
4141: bhs-oxadiaz-bala-betamethi
4142: bhs-nme35pyr-gly-betadcphee

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-138
4143:bhs-25methiaz-bala-betaibph
4144:bhs-24thioph-bala-beta23meoph
4145:ibhs-oxadiaz-bala-betatos
4146:tolhs-ithiadiaz-bala-betadtrif
4147:bhs-oxadiaz-gly-betapych
4148:tolhs-ithiadiaz-bala-betaamibe
4149:bhs-24thiaz-bala-betadbph
4150:bhs-24thioph-bala-betaphethioa
4151:phhs-25oxaz-bala-betadcphch
1D4152:tolhs-24thiaz-gly-betafluo
4153:phhs-25methiaz-gly-betaimid
4154:tolhs-oxadiaz-gly-betadtrif
4155:bhs-nme35pyr-ala-betadmph
4156:bim-25thiaz-bala-betampy
154157:phhs-25methiaz-bala-betathioph
4158:phhs-nme35pyr-gly-zdapch
4159:bhs-25methiaz-gly-betatos
4160:tolhs-25oxaz-bala-betahc
4161:2py-me24thiaz-ala-beta34meoph
204162:tolhs-me24thioph-gly-beta34meoph
4163:bim-oxadiaz-gly-betadcph
4164:ibhs-25thiaz-bala-betapbiph
4165:bhs-25thiaz-bala-betatos
4166:2py-25methiaz-bala-betapy
254167:tolhs-25methiaz-bala-zdapch
4168:gua-42pym-gly-betafluo
4169:bhs-nme35pyr-bala-betaphethioa
4170:tolhs-24thioph-bala-psdapee
4171:phhs-25oxaz-gly-ibsdap
304172:ibhs-25thiaz-gly-betabnaphth
4173:2py-25thiaz-gly-beta35dbph
4174:ibhs-oxadiaz-gly-betaimid
4175:bhs-me25thioph-ala-betapy
4176:phhs-24thioph-gly-betathioph
354177:ibhs-24thiaz-gly-betaomebendi
4178:bim-25fhiaz-ala-zdap
4179:ibhs-25methiaz-bala-betahmph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-139-
4180: ibhs-24thioph-gly-betahbcph
4181: bim-25oxaz-gly-betahbcph
4182: bhs-ithiadiaz-g1y-betadito
4183: bhs-24thioph-nmgly-betaipro
4184: bim-35thioph-ala-zdap
4185: ibhs-25oxaz-gly-betadcphch
4186: phhs-24thiaz-bala-zdapee
4187: bhs-me24thiaz-bala-betaph
4188: bim-nme35pyr-ala-zdap
4189:tolhs-25thiaz-gly-betaomebendi
4190: bhs-24thioph-gly-psdapee
4191: tolhs-nme35pyr-bala-zdap
4192: tolhs-nme35pyr-gly-aspaba
4193: ibhs-oxadiaz-bala-betatbuph
4194:tolhs-25oxaz-gly-betameph
4195: 2py-thiadiaz-bala-betadcph
4196: bim-24im-gly-betapy
4197: phhs-24thioph-gly-betadtrif
4198: bhs-nme35pyr-bala-betabph
4199:2py-24thioph-bala-aspibua
4200: bhs-25methiaz-bala-betafbph
4201: bhs-24thiaz-bala-betaibph
4202: impy-25thiaz-nmgly-psdap
4203: phhs-oxadiaz-gly-betatos
4204:phhs-24thioph-gly-betal3bendi
4205: bim-triaz-leu-betadcph
4206: phhs-25methiaz-bala-csdap
4207: phhs-nme35pyr-gly-betainyl
4208: ibhs-nme35pyr-bala-beta4bph
4209:phhs-ithiadiaz-bala-betahni
4210: 2py-24th iaz-ala-psdap
4211: tolhs-25thiaz-bala-beta4bph
4212: bhs-25thiaz-gly-beta34dcph
4213: bhs-25thiaz-bala-betafu3
4214:phhs-24thioph-gly-beta35dbph
4215: phhs-24thiaz-gly-betadmoph
4216: bhs-oxadiaz-ala-beta13bendi

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-140-
4217: 2pmhs-25oxaz-bala-betafluo
4218: phhs-25oxaz-gly-zdaptb
4219: phhs-24thiaz-bala-betamesu
4220: ibhs-24thioph-gly-betaph
4221: tolhs-nme35pyr-gly-betafphe
4222: bhs-25methiaz-gly-betabthioph
4223: bhs-25thiaz-bala-psdap
4224: tolhs-25methiaz-gly-betaibph
4225: bhs-me25oxaz-leu-betadcph
4226:2pmhs-25oxaz-bata-beta34dcph
4227: 2pmhs-24thiaz-bala-betabmph
4228: bim-24im-ala-betapy
4229: phhs-25thiaz-gly-betathio3
4230: ibhs-nme35pyr-gly-betahbcph
4231:tolhs-25oxaz-bala-betaol
4232: phhs-nme35pyr-bala-zdapch
4233: phhs-24thiaz-gly-betacph
4234: ibhs-24thioph-gly-betamethi
4235: 2pmhs-25thiaz-gly-betabpy
4236:phhs-24thioph-bala-zdapee
4237: phhs-oxadiaz-bala-betapyee
4238: ibhs-24thioph-gly-csdap
4239: tolhs-oxadiaz-bala-betapyr
4240: bim-25thiaz-bala-aspibua
4241:bhs-oxadiaz-gly-ibsdap
4242: bim-53pyrazo-leu-betadcph
4243: bhs-ithiadiaz-bala-betafu3
4244: tolhs-ithiadiaz-bala-betambiph
4245: ibhs-25methiaz-bala-betabdimo
4246:impy-25thiaz-gly-betathiobe
4247: bhs-oxadiaz-gly-betaanaphth
4248: tolhs-25thiaz-bala-betahdbph
4249: bhs-oxadiaz-bala-betathio3
4250: bhs-25fur-leu-betadcph
4251:2py-me25thioph-ala-betadcph
4252: phhs-24thioph-bala-betamethi
4253: 2pmhs-25oxaz-gly-psdap

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-141-
4254: bhs-oxadiaz-gly-betahmo
4255: phhs-nme35pyr-bala-aspbzla
4256: nmhs-25thiaz-gly-betadcph
4257: bhs-24thiaz-ala-betadmoph
4258: impy-25thiaz-bala-psdap
4259: bim-24oxaz-gly-betapy
4260: bhs-25oxaz-gly-suabu
4261: bim-25thioph-gly-betapy
4262: bim-25methiaz-bala-aspibua
104263: bhs-oxadiaz-gly-betahdcph
4264: ibhs-24thiaz-bala-betacthioph
4265: tolhs-24thiaz-gly-betaamibe
4266: tolhs-24thioph-bala-beta3quin
4267: ibhs-25thiaz-bala-betamesu
154268: phhs-oxadiaz-bala-zdapee
4269: ibhs-24thiaz-bala-betahmofu
4270: bhs-25methiaz-bala-betaet
4271: ibhs-25thiaz-gly-betaheph
4272: ibhs-24thiaz-bala-beta34meoph
204273: ibhs-nme35pyr-bala-betathioph
4274: bhs-25methiaz-bala-betafluo
4275: bim-25oxaz-ala-betapy
4276: phhs-24thioph-bala-betapbiph
4277: tolhs-24thiaz-gly-betadito
254278: bim-42oxaz-ala-psdap
4279: bhs-24thiophme-gly-zdap
4280: tolhs-24thiaz-bala-betadcphtb
4281: bhs-25thiaz-bala-betabpy
4282: phhs-me25oxaz-leu-betaph
304283: phhs-nme35pyr-gly-beta3quin
4284: bhs-oxadiaz-bala-betabthioph
4285: bim-nme35pyr-bala-aspibua
4286: bhs-25thiaz-bala-betaphethio
4287: ibhs-25thiaz-bala-betaoxaz
354288: bhs-nme35pyr-gly-zdaptb
4289: ibhs-25oxaz-bala-busu2be
4290: bhs-25methiaz-nmgly-betadmoph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 142 -
4291: tolhs-oxadiaz-bala-betameph
4292: bhs-24thiaz-gly-betabiph
4293: ibhs-25rnethiaz-bala-betapym
4294: tolhs-nme35pyr-gly-betathioph
4295:tolhs-25methiaz-bala-psdapch
4296: 2py-25thiaz-gly-asppha
4297: tolhs-24thiaz-bala-betahc
4298: 2pmhs-25thioph-gly-betapy
4299: ibhs-24thiaz-bala-betaph
4300:impy-25methiaz-bala-betamethi
4301: phhs-oxadiaz-gly-betathiobe
4302: ibhs-25thiaz-gly-betathioph
4303: gua-25thiaz-gly-betacthioph
4304: phhs-24thioph-gly-beta3quin
4305:phhs-oxadiaz-bala-betafph
4306: phhs-ithiadiaz-bala-betaoxope
4307; tolhs-25methiaz-bala-betahdcph
4308: bhs-24oxaz-leu-psdap
4309: ibhs-24thiaz-bala-betahdcph
4310:gua-24thiaz-gly-betahc
4311: phhs-24thiaz-bala-betadbph
4312: 2pmhs-25oxaz-gly-betatbuph
4313: ibhs-24thioph-bala-psdap
4314: bim-24thioph-bala-betapy
4315:tolhs-24thiaz-gly-beta13bendi
4316: pahs-25thiaz-gly-betapy
4317: thazep-24thiaz-bala-zdap
4318: phhs-24thioph-gly-betameph
4319; impy-24thioph-gly-betaipr
4320;2py-42nmeim-bala-betatrif
4321: phhs-24thiaz-gly-psdapee
4322: phhs-oxadiaz-gly-beta35dbph
4323: thpym-24thiaz-gly-betacbph
4324: phhs-24thiaz-bala-zdap
4325:ibhs-24thioph-bala-betapyee
4326: tolhs-ithiadiaz-gly-betaipro
4327: bhs-26py-gly-zdap

CA 02371604 2001-10-24
WO 00166618 f~CTIEP00103469
-143-
4328:phhs-ithiadiaz-bala-beta13bendi
4329:ibhs-25methiaz-gly-betaheph
4330:bhs-nme35pyr-gly-betacph
4331:bhs-thiadiaz-leu-zdap
4332:tolhs-24thiaz-gly-betafu3
4333:2py-ithiadiaz-leu-psdap
4334:thpym-42pym-gly-beta35dbph
4335:bhs-35fur-leu-zdap
4336:bim-me25thiaz-ala-psdap
4337:bim-thiadiaz-bala-betapy
4338:bhs-25thiaz-bala-betadcphee
4339:ibhs-ithiadiaz-bala-betadhbfu
4340:phhs-24thiaz-bala-betafu2
4341:bhs-oxadiaz-bala-aspibua
4342:tolhs-25thiaz-gly-betamethioph
4343:bhs-25oxaz-nmgly-betadhbfu
4344:3pmhs-24thiaz-bala-betapy
4345:2py-42pym-ala-zdap
4346:tolhs-24thioph-gly-betaoxaz
4347:phhs-25oxaz-bala-betaimid
4348:bim-25oxaz-bala-aspibua
4349:phhs-nme35pyr-gly-betathiobe
4350:ibhs-24thioph-bala-betahc
4351:bhs-nme35pyr-bala-zdapee
4352:2py-24thiaz-bala-betaoxope
4353:bhs-25thiaz-ala-betamesu
4354:phhs-25methiaz-bala-betah35dc
4355:bhs-25oxaz-gly-betacbph
4356:tolhs-25thiaz-gly-beta3quin
4357:bhs-oxadiaz-gly-betadbph
4358:tolhs-25oxaz-bala-betameph
4359:phhs-24thiaz-gly-beta4bph
4360:2py-me25thiaz-leu-betadcph
4361:2py-nme35pyr-gly-betapy
4362:bhs-25oxaz-bala-betacph
4363:bhs-25methiaz-bala-betal3bendi
4364:dhim-25thiaz-gly-psdap

CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
- 144 -
4365:2py-42nmeim-bala-betadbph
4366:bhs-ithiadiaz-gly-betapytb
4367:phhs-ithiadiaz-bala-betatos
4368:tolhs-oxadiaz-bala-betafu3
4369:2py-24thiaz-gly-aspbzla
4370:bhs-25oxaz-bala-betaibph
4371:ibhs-ithiadiaz-gly-betahb
4372:ibhs-25thiaz-bala-betadcph
4373:ibhs-24thiaz-gly-beta23meoph
104374:tolhs-nme35pyr-bala-betatbuph
4375:bhs-24thioph-bala-betapyr
4376:ibhs-nme35pyr-gly-betahcbph
4377:bhs-53pyrazo-gly-psdap
4378:pahs-24thiaz-bala-betameph
154379:ibhs-oxadiaz-gly-betabpy
4380:tolhs-nme35pyr-gly-betatrif
4381:phhs-25thiaz-bala-betabdimo
4382:ibhs-25oxaz-bala-betaheph
4383:tolhs-24thiaz-gly-betaibph
204384:2py-triaz-ala-betapy
4385:bhs-25methiaz-gly-betadmph
4386:phhs-25thiaz-bala-betaibph
4387:ibhs-25thiaz-giy-betahcbph
4388:phhs-oxadiaz-bala-beta35dbph
254389:bim-nme35pyr-ala-psdap
4390:phhs-25oxaz-bala-betahmofu
4391:bim-25thiaz-bala-betatos
4392:ibhs-25oxaz-bala-psdapee
4393:hts-24thioph-gly-betapy
304394:bhs-25methiaz-bala-beta4bph
4395:bhs-me25thiaz-gly-betapy
4396:bhs-25methiaz-gly-betaibph
4397:bhs-25oxaz-bala-betaanaphth
4398:bhs-25thiaz-gly-betaphethio
354399:phhs-24thiaz-bala-beta23meoph
4400:tolhs-24thiaz-gly-csdap -
4401:phhs-oxadiaz-gly-betaol

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 145
4402:ibhs-nme35pyr-gly-aspibua
4403:pahs-25oxaz-gly-betapy
4404:bhs-oxadiaz-bala-beta13bendi
4405:phhs-24thioph-gly-betatbph
4406:ibhs-25thiaz-gly-betaimid
4407:bhs-oxadiaz-nmgly-betabnaphth
4408:phhs-25oxaz-gly-betainyl
4409:bim-ithiadiaz-gly-aspbzla
4410:tolhs-24thioph-gly-betacph
104411:bhs-nme35pyr-gly-betaphethio
4412:2py-42oxaz-gly-betapy
4413:ibhs-24thiaz-bala-betamesu
4414:bhs-24thioph-bala-betahb
4415:tolhs-oxadiaz-bala-betahph
154416:bhs-nme35pyr-bala-betapytb
4417:tolhs-24thiaz-gly-betahc
4418:bim-35thioph-leu-betadcph
4419:bhs-25methiaz-bala-betahmo
4420:bim-me25thioph-gly-beta34meoph
204421:4pmhs-25thiaz-gly-betapy
4422:phhs-25thiaz-bala-betahmph
4423:phhs-25methiaz-gly-aspbzla
4424:gua-24thiaz-gly-betacthioph
4425:thpym-25thioph-gly-betacbph
254426:dhim-25thiaz-gly-betapy
4427:ibhs-25methiaz-bala-zdap
4428:bhs-25methiaz-bala-busu2be
4429:bim-24thioph-gly-betahmph
4430:phhs-nme35pyr-gly-betaipro
304431:bhs-me24oxaz-ala-beta34meoph
4432:bhs-nme35pyr-ala-betacthioph
4433:bim-42oxaz-afa-betapy
4434:bhs-24thioph-gly-betadmph
4435:phhs-25methiaz-gly-betahbcph
354436:tolhs-24thioph-gly-betathiobe
4437:ibhs-25oxaz-bala-betaoxaz
4438:ibhs-nme35pyr-bala-betameph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-146
4439: tolhs-ithiadiaz-gly-betapbiph
4440: bim-24thioph-bala-aspbzla
4441: 2py-nme35pyr-leu-betapy
4442: dhthi-24oxaz-gly-betapy
4443: tolhs-24thioph-gly-betadmph
4444: phhs-25thiaz-bala-psdaptb
4445: 2py-me25oxaz-gly-beta34meoph
4446: tolhs-oxadiaz-gly-betapyr
4447: bhs-24thiaz-gly-betamethi
104448: bhs-24thiaz-bala-betaph
4449: bhs-oxadiaz-bala-betahdcph
4450: gua-25thioph-gly-betahcbph
4451: 2py-52thiaz-gly-betainyl
4452: tolhs-oxadiaz-bala-betacthioph
154453: 2py-25methiaz-gly-betadcph
4454: bhs-oxadiaz-gly-betatrif
4455: tolhs-24thioph-gly-betabmh
4456: tolhs-25methiaz-bala-betadcph
4457: bim-triaz-ala-betadcph
204458: bhs-nme35pyr-gly-beta3quin
4459: phhs-24thioph-gly-betahb
4460: phhs-25thiaz-gly-betafbph
4461: impy-42nmeim-bala-betadtrif
4462: phhs-24thiaz-bala-suabu
254463: tolhs-24thioph-bala-betapyr
4464: bhs-25thiaz-ala-betadmoph
4465: bhs-25thiaz-bala-betah35dc
4466: hts-24thiaz-gly-betapy
4467: phhs-ithiadiaz-bala-betahdcph
304468: ibhs-24thiaz-bala-betamethioph
4469: bim-oxadiaz-gly-psdap
4470: bim-oxadiaz-leu-zdap
4471: ibhs-oxadiaz-gly-ibsdap
4472: tolhs-me24thioph-leu-beta34meoph
354473: phhs-ithiadiaz-bala-aspaba
4474: ibhs-oxadiaz-bala-betah35dc
4475: phhs-25methiaz-bala-betapych

CA 02371604 2001-10-24
WO OOI66618 PCTIEP00103469
- 147 -
4476:phhs-24thioph-gly-betabph
4477:impy-25thiaz-gly-betambiph
4478:bhs-25thiaz-gly-betafu2
4479:ibhs-oxadiaz-gly-psdapee
4480:bhs-24thioph-bala-betaimid
4481:tolhs-24thioph-gly-psdap
4482:ibhs-oxadiaz-bala-psdapch
4483.phhs-24thiaz-gly-betabthioph
4484:bim-26py-gly-betadcph
4485:bhs-24thioph-bala-betahmph
4486:ibhs-25oxaz-gly-betafphe
4487:bhs-25oxaz-gly-betaipr
4488:tolhs-24thiaz-gly-betahdcph
4489:gua-24oxaz-gly-betahmofu
4490:tolhs-24thioph-bala-betacph
4491:tolhs-24thioph-gly-beta34meoph
4492:bhs-oxadiaz-bala-beta35dbph
4493:phhs-ithiadiaz-gly-betaet
4494:bim-24thioph-bala-csdap
4495:bhs-25methiaz-gly-zdaptb
4496:bhs-nme35pyr-bala-betaphethio
4497:ibhs-24thiaz-gly-betathioph
4498:tolhs-24thiaz-bala-betapych
4499:tolhs-oxadiaz-gly-betadcphch
4500:bhs-ithiadiaz-leu-betadcph
4501:phhs-nme35pyr-gly-betaimid
4502:tolhs-24thiaz-gly-betahni
4503:2py-26py-gly-csdap
4504:bhs-triaz-bala-zdap
4505:tolhs-25oxaz-bala-betapyee
4506:phhs-oxadiaz-gly-betabediox
4507:bhs-25thiaz-gly-betapy
4508:tolhs-ithiadiaz-bala-beta23meoph
4509:gua-26py-gly-betambiph
4510:2pmhs-24thioph-gly-betameph
4511:phhs-oxadiaz-bala-betaipro
4512:tolhs-nme35pyr-gly-betaimid

CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-148
4513.tolhs-nme35pyr-gly-beta34dcph
4514:phhs-25thiaz-bala-betabpy
4515:2py-24thioph-gly-psdap
4516:ibhs-24thioph-gly-betadcphch
4517:phhs-25methiaz-gly-betafphe
4518:tolhs-25methiaz-bala-betambiph
4519:tolhs-24thiaz-bala-betatrif
4520:phhs-oxadiaz-gly-betahc
4521:bim-oxadiaz-bala-zdap
4522:phhs-25methiaz-bala-betahb
4523:phhs-25methiaz-gly-zdapee
4524:bim-25thiaz-gly-betadmph
4525:phhs-25oxaz-gly-betatbuph
4526:phhs-25oxaz-gly-zdapee
4527:bhs-nme35pyr-ala-betahmph
4528:2py-me24thiaz-ala-zdap
4529:tolhs-ithiadiaz-bala-betahdbph
4530:ibhs-24thiaz-gly-zdapee
4531:tolhs-25methiaz-bala-betadcphee
4532:phhs-nme35pyr-bala-betaanaphth
4533:bhs-nme35pyr-bala-betaanaphth
4534:tolhs-nme35pyr-gly-betathiome
4535:ibhs-25methiaz-gly-betacthioph
4536:bhs-24thioph-gly-betah35dc
4537:bim-24oxaz-ala-psdap
4538:ibhs-oxadiaz-gly-betadcphee
4539:tolhs-oxadiaz-bala-betaol
4540:ibhs-ithiadiaz-bala-aspbzla
4541:2 py-26 py-ala-zd a
p
4542:tolhs-oxadiaz-gly-betafu3
4543:bhs-me24thioph-leu-zdap
4544:dhpyrr-24oxaz-gly-betameph
4545:bhs-24thiaz-gly-psdap
4546:tolhs-oxadiaz-bala-betambiph
4547:phhs-24thioph-gly-betafphe
4548:tolhs-ithiadiaz-bala-betacbph
4549:phhs-24thiaz-bala-betadcphee

CA 02371604 2001-10-24
WU 00/66618 PCTlEP00103469
-149
4550:ibhs-25oxaz-gly-betampy
4551:phhs-oxadiaz-bala-aspaba
4552:bim-25oxaz-bala-betapyr
4553:phhs-25oxaz-bala-beta35dbph
4554:ibhs-25thiaz-bala-ibsdap
4555:ibhs-nme35pyr-gly-betaoxope
4556:tolhs-oxadiaz-gly-betabpy
4557:phhs-nme35pyr-bala-beta3quin
4558:tolhs-nme35pyr-gly-betamesu
104559:bhs-24thiaz-bala-betacph
4560:ibhs-nme35pyr-bala-betaheph
4561:2pmhs-24thioph-bala-beta4bph
4562:bhs-thiadiaz-bala-betapy
4563:phhs-nme35pyr-bala-betadbph
154564:2py-26py-gly-betapy
4565:bim-me24thioph-ala-psdap
4566:tolhs-me24thioph-ala-betaph
4567:phhs-24thioph-bala-betacthioph
4568:phhs-ithiadiaz-bala-betapym
204569:bhs-24thiaz-bala-betatrif
4570:phhs-25thiaz-bala-betaimid
4571:bhs-24thiaz-bala-betaet
4572:2pmhs-24thioph-bala-beta13bendi
4573:2py-me24thiaz-leu-psdap
254574:tolhs-24thioph-bala-betaph
4575:ibhs-25oxaz-gly-betahmo
4576:phhs-nme35pyr-bala-betapytb
4577:tolhs-ithiadiaz-gly-betadmph
4578:tolhs-ithiadiaz-gly-betahmofu
304579:phhs-24thioph-bala-betahcbph
4580:phhs-25rnethiaz-gly-beta4bph
4581:phhs-nme35pyr-bala-betafluo
4582:tolhs-24thiaz-gly-betah35dc
4583:ibhs-25methiaz-gly-betaet
354584:ibhs-25methiaz-bala-betabmph
4585:tolhs-25oxaz-gly-betahph
4586:bhs-ithiadiaz-nmgly-betameph

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 150
4587: ibhs-ithiadiaz-bala-ibsdap
4588: 2pmhs-25thiaz-bala-zdap
4589: bhs-25oxaz-gly-beta3quin
4590: ibhs-ithiadiaz-gly-psdap
4591: tolhs-ithiadiaz-bala-betathio3
4592: phhs-24thiaz-bala-betahdbph
4593: phhs-25methiaz-bala-betafu2
4594: bhs-nme35pyr-bala-betafphe
4595: ibhs-24thioph-gly-betapym
104596: toihs-25thiaz-gly-csdap
4597: ibhs-nme35pyr-gly-betafphe
4598: gua-24thiaz-gly-betabediox
4599: bim-25thioph-gly-betameph
4600: 2py-25oxaz-gly-zdap
154601: ibhs-ithiadiaz-gly-betabediox
4602: bhs-25oxaz-gly-betabediox
4603: ibhs-25methiaz-bala-betah35dc
4604: bhs-24thiazme-ala-betameph
4605: gua-24thiaz-gly-betaimid
204606: bhs-25thiaz-gly-betaipro
4607: ibhs-25methiaz-bala-betafu2
4608: bhs-24thioph-bala-psdapee
4609: phhs-24thiaz-gly-betah35dc
4610: bhs-52thiaz-ala-psdap
254611: ibhs-25oxaz-gly-betapyee
4612: ibhs-25thiaz-gly-psdap
4613: nmhs-25oxaz-bala-zdap
4614: tolhs-24thiaz-gly-betabdimo
4615: bhs-25thiaz-afa-beta23meoph
304616: gua-24thiaz-gly-betampy
4617: tolhs-ithiadiaz-gly-betatrif
4618: bhs-42pym-ala-betameph
4619: bhs-25methiaz-ala-betacthioph
4620: phhs-oxadiaz-bala-betadcphtb
354621: bhs-24thioph-bala-betafu3
4622: tolhs-25oxaz-bafa-betafu2
4623: bhs-25oxaz-bala-betaamibe

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 151
4624: bim-25methiaz-gly-betadcph
4625: gua-24thiaz-gly-betacph
4626: bhs-24thiaz-nmgly-beta34meoph
4627: tolhs-me25thioph-bala-betaph
4628: bhs-nme35pyr-gly-betafluo
4629: ibhs-25thiaz-bala-betahmph
4630: phhs-25oxaz-bala-betaph
4631: tolhs-me24thioph-ala-beta34meoph
4632: bhs-nme35pyr-gly-beta35dbph
104633: dimethpym-24thiaz-gly-betadcph
4634: ibhs-25methiaz-bala-betaimid
4635: ibhs-24thioph-bala-betabthioph
4636: tolhs-nme35pyr-bala-betapyee
4637: hyd-25thiaz-gly-betainyl
154638: tolhs-25oxaz-bala-betapyr
4639: bhs-ithiadiaz-gly-betahdcph
4640: bhs-oxadiaz-bala-betadmoph
4641: phhs-me25oxaz-ala-betadcph
4642: phhs-25methiaz-bala-betameph
204643: bhs-24thiaz-gly-betahc
4644: bhs-me24thioph-leu-betapy
4645: ibhs-25methiaz-bala-betahc
4646: phhs-me24oxaz-ala-betaph
4647: phhs-24thiaz-gly-betahmofu
254648: bhs-ithiadiaz-ala-betadmoph
4649: dimethpym-25thioph-gly-betahdcph
4650: bim-25methiaz-bala-betadcph
4651: bhs-24thioph-nmgly-betadmoph
4652: tolhs-25methiaz-bala-betatbuph
304653: phhs-24thiaz-gly-betathiome
4654: phhs-25oxaz-gly-psdaptb
4655: ibhs-ithiadiaz-bala-betapbiph
4656: ibhs-nme35pyr-bala-betaet
4657: tolhs-25thiaz-bala-zdaptb
354658: bhs-25thiaz-gly-beta3quin
4659: bim-52thiaz-ala-betainyl
4660: bhs-24thioph-ala-betadito

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-152
4661: 2py-42nmeim-ala-psdap
4662: phhs-25thiaz-gly-beta3quin
4663: tolhs-oxadiaz-bala-beta13bendi
4664: ibhs-25methiaz-gly-betabmph
4665: ibhs-25methiaz-bala-beta23meoph
4666: bhs-24thioph-gly-betahb
4667: tolhs-oxadiaz-gly-betafluo
4668: gua-24thiaz-gly-betabph
4669: ibhs-25oxaz-gly-aspaba
104670: bhs-25oxaz-ala-zdap
4671: tolhs-25thiaz-bala-betahni
4672: bim-42nmeim-gly-betamesu
4673: dhthi-24thiaz-gly-betapy
4674: phhs-nme35pyr-bala-psdap
154675: ibhs-25oxaz-gly-betatos
4676: bhs-nme35pyr-gly-betapyee
4677: 2py-24thiaz-bala-psdap
4678: tolhs-oxadiaz-gly-betah35dc
4679: tolhs-24thioph-bala-betapytb
204680: gua-24thiaz-gly-beta34dcph
4681: phhs-24thioph-bala-zdap
4682: bhs-ithiadiaz-bala-betahni
4683: gua-25thiaz-gly-betampy
4684: phhs-nme35pyr-bala-beta34dcph
254685: tolhs-nme35pyr-bala-betahph
4686: bhs-24thioph-ala-betameph
4687: phhs-25thiaz-bala-betabediox
4688: ibhs-24thioph-gly-betahmph
4689: tolhs-nme35pyr-bala-betahmph
304690: bhs-25oxaz-gly-betampy
4691: bhs-ithiadiaz-bala-beta4bph
4692: phhs-25methiaz-gly-betadtrif
4693: bhs-me25thiaz-gly-zdap
4694: phhs-25oxaz-gly-busu2be
354695: bhs-nme35pyr-bala-betafu2
4696: ibhs-25methiaz-bala-betathiobe
4697: ibhs-25oxaz-gly-betabdimo

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 153
4698: bim-ithiadiaz-ala-psdap
4699: tolhs-oxadiaz-gly-betaimid
4700: ibhs-24thioph-gly-betaftrif
4701: 2py-me25thiaz-ala-betadcph
4702: ibhs-25methiaz-bala-suabu
4703: bhs-24thiaz-bala-betafu3
4704: ibhs-25thiaz-gly-beta13bendi
4705: bim-53pyrazo-gly-zdap
4706: bhs-nme35pyr-bala-betapych
4707:bhs-25methiaz-bala-betahdcph
4708: phhs-24thiaz-gly-betaphethio
4709: ibhs-25methiaz-gly-betahmofu
4710: bhs-25oxaz-bala-betahmofu
4711: phhs-25methiaz-gly-betafbph
4712:ibhs-24thiaz-gly-betamethi
4713: ibhs-25methiaz-gly-psdap
4714: phhs-nme35pyr-bala-betadmph
4715: phhs-oxadiaz-gly-betal3bendi
4716: tolhs-24thiaz-bala-betadcphee
4717:bhs-ithiadiaz-gly-betatos
4718: ibhs-25oxaz-gly-betaphethioa
4719: ibhs-nme35pyr-gly-beta4bph
4720: bhs-oxadiaz-nmgly-betahph
4721: tolhs-ithiadiaz-bala-betahcbph
4722:bhs-25thiaz-gly-betabdimo
4723: bhs-24thiaz-ala-ibsdap
4724: phhs-25methiaz-bala-betafph
4725: bhs-ithiadiaz-gly-betambiph
4726: gua-25methiaz-bala-betadcph
4727:bhs-nme35pyr-ala-betathioph
4728: ibhs-25thiaz-gly-betadcphtb
4729: bhs-nme35pyr-bala-betahni
4730: ibhs-24thiaz-bala-betaamibe
4731: bhs-me24thiaz-ala-zdap
4732:phhs-24thiaz-gly-betaph
4733: ibhs-25methiaz-gly-betahb
4734: bhs-24thiaz-gly-betatrif

CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 154 -
4735; bhs-25oxaz-gly-aspbzla
4736: phhs-nme35pyr-gly-betadmoph
4737: bim-25oxaz-ala-zdap
4738: gua-24thiaz-gly-betaibph
4739: ibhs-nme35pyr-gly-betapyee
4740: dhim-25thiaz-gly-zdap
4741: tolhs-25methiaz-bala-beta3quin
4742: tolhs-me24thioph-bala-betadcph
4743: ibhs-oxadiaz-bala-betaomebendi
104744: tolhs-25thiaz-gly-betaheph
4745: bhs-53pyrazo-leu-betapy
4746: bim-25fur-bala-psdap
4747: bim-25thiaz-leu-psdap
4748: bim-42nmeim-bala-zdap
154749: gua-26py-gly-betabmph
4750: bim-me25thiaz-leu-beta34meoph
4751: bim-oxadiaz-bala-asppha
4752: bhs-24im-gly-betapy
4753: tolhs-25thiaz-bala-betadtrif
204754: phhs-25methiaz-bala-betapyr
4755: 2py-24th iaz-gly-betadito
4756: ibhs-24thioph-gly-betadmph
4757: phhs-oxadiaz-bala-psdaptb
4758: bhs-me24thioph-ala-betapy
254759: tolhs-me25thiaz-leu-psdap
4760: tolhs-24thiaz-bala-beta35dbph
4761: pahs-24thiaz-gly-betapy
4762: dhim-25thioph-ala-betapy
4763: bhs-24thioph-bala-betahmo
304764: bhs-me24oxaz-ala-betaph
4765: ibhs-25oxaz-gly-betatbuph
4766: thpym-26py-gly-betainyl
4767: bhs-25methiaz-bala-beta23meoph
4768: phhs-24thiaz-bala-betabpy
354769: 2py-53pyrazo-ala-zdap
4770: tolhs-25methiaz-bala-betabpy
4771: phhs-oxadiaz-bala-betahdcph

CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-155
4772; bhs-24thioph-gly-betamethioph
4773: phhs-ithiadiaz-gly-betahdbph
4774: phhs-25thiaz-gly-zdaptb
4775: bhs-ithiadiaz-gly-betabthioph
4776: bhs-24thioph-bala-beta34dcph
4777: bhs-24thiaz-gly-betahmofu
4778: bhs-25thiaz-bala-betadcphch
4779: tolhs-25methiaz-gly-betatbuph
4780: ibhs-24thiaz-bafa-aspaba
4781: thpym-25thiaz-gly-beta35dbph
4782: gua-26py-gly-betacph
4783: ibhs-oxadiaz-bala-betadcph
4784: ibhs-24thiaz-gly-betainyl
4785: bim-24py-gly-zdap
4786: 2py-52thiaz-ala-zdap
4787: phhs-24thiaz-gly-beta13bendi
4788: ibhs-ithiadiaz-bala-busu2be
4789: bhs-35thioph-ala-betadcph
4790: phhs-25oxaz-bala-beta34dcph
4791: bhs-24thiaz-gly-betabthioph
4792: phhs-24thiaz-bala-betaamibe
4793: bhs-24thioph-gly-betadcph
4794: tolhs-ithiadiaz-gly-betatbuph
4795: ibhs-nme35pyr-bala-betaol
4796: tolhs-25methiaz-gly-betacbph
4797: phhs-24thiaz-bala-betadmph
4798: tolhs-24thioph-bala-betaipro
4799: bhs-25thiaz-ala-betaipro
4800: bhs-25thiaz-bala-betaamibe
4801: tolhs-24thiaz-bala-betambiph
4802: bhs-triaz-gly-betapy
4803: bhs-25oxaz-gly-betathioph
4804: bhs-25oxaz-bala-betafu3
4805: ibhs-25oxaz-bala-zdapch
4806: bhs-35thioph-bala-betadcph
4807: phhs-oxadiaz-bala-betadcphch
4808: phhs-ithiadiaz-bala-asppha

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-156
4809: bim-me24thiaz-gly-beta34meoph
4810: ibhs-25methiaz-gly-betaftrif
4811: 3pmhs-25methiaz-bala-betapy
4812: ibhs-25thiaz-gly-betadhbfu
4813: tolhs-24thioph-gly-betaipr
4814: ibhs-25thiaz-gly-betabmph
4815: bhs-25methiaz-bala-zdaptb
4816: bhs-25thiaz-ala-betaheph
4817: bhs-ithiadiaz-bala-betahmph
104818: bim-42pym-gly-betadcph
4819: bhs-25methiaz-gly-psdap
4820: phhs-25oxaz-gly-betacph
4821: bhs-nme35pyr-gly-zdap
4822: bhs-oxadiaz-bala-beta34meoph
154823: tolhs-me24thiaz-leu-betapy
4824: ibhs-25oxaz-bala-betahc
4825; bhs-25methiaz-bala-betahmph
4826: ibhs-24thiaz-bala-zdapch
4827: tolhs-25methiaz-gly-betadmph
204828: 2py-26py-gly-betadcph
4829: dhim-24thiaz-ala-betadcph
4830: bhs-24thiaz-ala-betacph
4831: phhs-ithiadiaz-bala-aspibua
4832: bhs-25thiaz-ala-betahph
254833: phhs-24thioph-bala-betahdcph
4834: bhs-24thiaz-nmgly-betathioph
4835: tolhs-ithiadiaz-gly-asppha
4836: ibhs-24thioph-gly-betaphethioa
4837: phhs-24thiaz-bala-psdap
304838: phhs-25oxaz-bala-betathio3
4839: ibhs-24thioph-gly-betatbuph
4840: ibhs-nme35pyr-gly-betadcphee
4841: phhs-me24thiaz-bala-zdap
4842: ibhs-24thioph-bala-betahdbph
354843: tolhs-25thiaz-bala-betaipr
4844: gua-26py-gly-betabenfu
4845: ibhs-oxadiaz-bala-betadtrif

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-157
4846: dhim-24thiaz-gly-betahcbph
4847: dhim-25thiaz-ala-betadcph
4848: tolhs-24thioph-gly-betabnaphth
4849: bhs-24thiaz-bala-betahmo
4850: ibhs-oxadiaz-bala-betadbph
4851: phhs-25methiaz-bala-betahmo
4852: ibhs-25methiaz-gly-betapy
4853: tolhs-25methiaz-gly-zdapch
4854: phhs-25oxaz-bala-betahcbph
104855: tolhs-nme35pyr-bala-betaet
4856: tolhs-ithiadiaz-bala-betapytb
4857: nmhs-24thiaz-gly-betadcph
4858: phhs-25thiaz-gly-betaibph
4859: tolhs-24thiaz-bala-betabph
154860: tolhs-25oxaz-bala-betaanaphth
4861: bhs-24thioph-bala-betabthioph
4862: phhs-oxadiaz-gly-betadmoph
4863: bim-me25oxaz-ala-psdap
4864: ibhs-25methiaz-bala-betahdbph
204865: bhs-24thioph-ala-betacph
4866: ibhs-24thioph-bala-betadhbfu
4867: ibhs-nme35pyr-bala-betaipr
4868: bim-25oxaz-bala-zdap
4869: bim-42nmeim-leu-zdap
254870: ibhs-oxadiaz-gly-betahdbph
4871: phhs-me24oxaz-ala-beta34meoph
4872: bhs-oxadiaz-bala-betahmo
4873: phhs-24thiaz-bala-betadhbfu
4874: bhs-25fur-bala-zdap
304875: tolhs-me25thioph-gly-betapy
4876: ibhs-25thiaz-gly-betafph
4877: 2py-me24thiaz-bala-betapy
4878: phhs-ithiadiaz-bala-beta4bph
4879: phhs-me25thioph-gly-zdap
354880: ibhs-24thioph-bala-betapytb
4881: dhim-26py-gly-betadcph
4882: phhs-25methiaz-gly-betaoxope

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-158-
4883: bhs-25thiaz-bala-betapy
4884: bim-25thiaz-gly-betapbiph
4885: phhs-25thiaz-bala-betahb
4886: bhs-ithiadiaz-gly-beta3quin
4887: ibhs-25thiaz-gly-betacthioph
4888: bhs-25methiaz-bala-ibsdap
4889: bim-42pym-ala-betainyl
4890: bhs-24thiaz-bala-betapym
4891: bim-25thiaz-bala-csdap
104892: bhs-25oxaz-gly-betamesu
4893: bhs-24thioph-ala-betahmph
4894: ibhs-25methiaz-bala-betahcbph
4895: tolhs-ithiadiaz-bala-psdapch
4896: tolhs-24thiaz-gly-betampy
154897: bhs-triaz-bala-psdap
4898: bhs-nme35pyr-gly-betabnaphth
4899: phhs-oxadiaz-bala-betabnaphth
4900: tolhs-25thiaz-bala-betamethioph
4901: tolhs-oxadiaz-gly-betadbph
204902: tolhs-nme35pyr-bala-betadhbfu
4903: bhs-24thiaz-ala-betaanaphth
4904: ibhs-25thiaz-gly-betadcphch
4905: bhs-oxadiaz-gly-betapbiph
4906: ibhs-ithiadiaz-gly-betampy
254907: tolhs-25thiaz-gly-aspaba
4908: bhs-nme35pyr-bala-betabdimo
4909: tolhs-oxadiaz-gly-betadcphtb
4910: tolhs-oxadiaz-bala-beta3quin
4911: bim-oxadiaz-bala-psdap
304912: phhs-25methiaz-bala-beta34meoph
4913: phhs-24thiaz-gly-betaftrif
4914: bhs-nme35pyr-gly-betacbph
4915: ibhs-oxadiaz-bala-suabu
4916: bhs-triaz-bala-betadcph
354917: 2py-24oxaz-leu-betapy
4918: dhim-42pym-ala-betainyl
4919: phhs-25oxaz-gly-betaftrif

CA 02371604 2001-10-24
W000166618 PCTlEP00/03469
-159
4920: tolhs-25thiaz-bala-betaanaphth
4921: bhs-thiadiaz-bala-psdap
4922: tolhs-24thioph-bala-betainyl
4923: tolhs-25oxaz-gly-betathioph
4924: bhs-42pym-ala-betapy
4925: 2py-26py-gly-beta23meoph
4926: phhs-ithiadiaz-gly-betahph
4927: phhs-25methiaz-gly-betapym
4928: ibhs-25methiaz-bala-betacthioph
104929: bhs-24thiaz-gly-betabenfu
4930: tolhs-25thiaz-bala-betaphethioa
4931: bhs-25thiaz-gly-ibsdap
4932: ibhs-25thiaz-bala-betainyl
4933: tolhs-24thioph-bala-psdaptb
154934: ibhs-24thiaz-bala-betadhbfu
4935: bhs-nme35pyr-bala-betaoxope
4936: tolhs-25methiaz-gly-beta13bendi
4937: ibhs-24thiaz-gly-beta34dcph
4938: bim-me24oxaz-ala-zdap
204939: phhs-nme35pyr-bala-betapbiph
4940: dhim-26py-ala-betadcph
4941: phhs-25methiaz-gly-betacthioph
4942: 2py-42nmeim-bala-zdap
4943: ibhs-25thiaz-gly-betahbcph
254944: ibhs-25thiaz-gly-betacph
4945: ibhs-25oxaz-gly-betacbph
4946: tolhs-25thiaz-bala-betadcph
4947: dhim-24oxaz-gly-betameph
4948: bhs-nme35pyr-gly-betatrif
304949: bhs-24thioph-bala-betahph
4950: bhs-nme35pyr-bala-aspibua
4951: bhs-25thiaz-gly-betamesu
4952: bim-me24oxaz-bala-betaph
4953: bhs-25oxaz-bala-betahb
354954: bim-ithiadiaz-ala-zdap
4955: phhs-oxadiaz-bala-betabmph
4956: bhs-oxadiaz-ala-betadito

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-160
4957:phhs-ithiadiaz-bala-betatbuph
4958:bhs-25oxaz-nmgly-betaipro
4959:2py-25fur-leu-psdap
4960:bhs-ithiadiaz-gly-asppha
4961:ibhs-25methiaz-gly-psdapch
4962:tolhs-25thiaz-gly-psdap
4963:bhs-oxadiaz-bala-betaet
4964:bhs-24thioph-bala-betamethioph
4965:bim-24thioph-gly-aspibua
4966:phhs-me25thioph-ala-betaph
4967:tolhs-nme35pyr-gly-ibsdap
4968:ibhs-24thioph-bala-beta23meoph
4969:tolhs-oxadiaz-bala-betadhbfu
4970:2py-25thiaz-gly-betadito
4971:phhs-ithiadiaz-gly-betahc
4972:phhs-24thioph-bala-betahbcph
4973:bhs-25methiaz-bala-betah35dc
4974:gua-25thioph-gly-betacph
4975:phhs-oxadiaz-gly-beta23meoph
4976:ibhs-24thioph-gly-betah35dc
4977:phhs-24thioph-gly-betaanaphth
4978:bim-24thiaz-bala-csdap
4979:2py-24thiaz-gly-betameph
4980:tolhs-24thioph-bala-betambiph
4981:2py-24im-leu-betadcph
4982:tolhs-nme35pyr-bala-betah35dc
4983:bhs-25oxaz-gly-ibsdap
4984:ibhs-25methiaz-gly-ibsdap
4985:tolhs-ithiadiaz-gly-betameph
4986:bhs-24thiaz-bala-betainyl
4987:bim-me25thiaz-bala-betadcph
4988:tolhs-25methiaz-bala-beta35dbph
4989:bhs-me25oxaz-gly-betaph
4990:phhs-25thiaz-gly-betadhbfu
4991:cima-42nmeim-bala-betapy
4992:phhs-24thiaz-bala-betabthioph
4993:bim-24thioph-leu-psdap

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-161-
4994:tolhs-me25oxaz-bala-beta34meoph
4995:ibhs-oxadiaz-bala-betainyl
4996:ibhs-ithiadiaz-bala-betaipr
4997:tolhs-nme35pyr-bala-betatos
4998:3pmhs-25thioph-gly-betapy
4999:2py-25thiaz-gly-aspaba
5000:bim-25methiaz-leu-betapy
5001:bim-24thiaz-bala-betadcph
5002:bhs-24thioph-gly-ibsdap
5003:2py-53pyrazo-gly-psdap
5004:ibhs-24thioph-gly-betaamibe
5005:tolhs-me24thiaz-gly-betapy
5006:bhs-52thiaz-gly-betameph
5007:ibhs-ithiadiaz-bala-betathioph
5008:ibhs-25thiaz-gly-betadmph
5009:bim-24im-gly-zdap
5010:ibhs-24thioph-bala-psdaptb
5011:bim-24thioph-bala-aspibua
5012:bhs-ithiadiaz-nmgly-betahmph
5013:bhs-25thiaz-bala-betainyl
5014:phhs-25methiaz-gly-betacbph
5015:bim-25thiaz-gly-betainyl
5016:phhs-24thioph-gly-betabediox
5017:phhs-oxadiaz-gly-betabnaphth
5018:ibhs-nme35pyr-gly-betabediox
5019:phhs-25thiaz-bala-betah35dc
5020:tolhs-nme35pyr-bala-beta34meoph
5021:phhs-me24thiaz-gly-psdap
5022:phhs-24thioph-bala-betabdimo
5023:tolhs-nme35pyr-gly-betaipro
5024:ibhs-25thiaz-gly-betaomebendi
5025:phhs-25oxaz-gly-betabmph
5026:dhim-26py-ala-betainyl
5027:thpym-26py-gly-betacbph
5028:ibhs-24thiaz-bala-betapytb
5029;ibhs-25thiaz-bala-betaimid
5030:ibhs-ithiadiaz-gly-betaol

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-162-
5031:ibhs-oxadiaz-bala-beta34dcph
5032:phhs-me25oxaz-gly-betaph
5033:tolhs-24thioph-bala-betafphe
5034:ibhs-24thioph-bala-betaftrif
5035:bim-42pym-ala-betapy
5036:bhs-nme35pyr-ala-betacph
5037:tolhs-nme35pyr-gly-betabenfu
5038:bim-42oxaz-ala-zdap
5039:ibhs-25oxaz-bala-betampy
5040:phhs-25thiaz-gly-betafphe
5041:dhim-26py-gly-beta34meoph
5042:ibhs-24thiaz-gly-betathiome
5043:bim-me24thioph-bala-betapy
5044:bim-24im-bala-zdap
5045:bhs-ithiadiaz-bala-betahbcph
5046:2py-25thiaz-gly-betadcph
5047:bim-me25oxaz-bala-betadcph
5048:phhs-25methiaz-bala-betathiobe
5049:ibhs-25oxaz-bala-beta3quin
5050:phhs-oxadiaz-bala-beta34meoph
5051:gua-42pym-gly-betabthioph
5052:bhs-35thioph-bala-betapy
5053:2py-42pym-gly-betainyl
5054:phhs-ithiadiaz-gly-beta4bph
5055:bhs-24thioph-bala-betahdcph
5056:ibhs-25methiaz-bala-betahni
5057:bim-25methiaz-leu-psdap
5058:tolhs-me25oxaz-ala-beta34meoph
5059:ibhs-25thiaz-bala-betampy
5060:phhs-25methiaz-gly-betaoxaz
5061:2pmhs-42pym-gly-betainyl
5062:tolhs-nme35pyr-gly-betapyr
5063:tolhs-25methiaz-bala-betapych
5064:tolhs-oxadiaz-gly-betadito
5065:tolhs-me25oxaz-ala-psdap
5066:bhs-ithiadiaz-bala-beta3quin
5067:2py-25oxaz-ala-psdap

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-163-
5068:bim-24thioph-leu-betapy
5069:tolhs-25methiaz-bala-betahmo
5070:bhs-25methiaz-bala-zdapch
5071:bhs-24thiaz-bala-betamethi
5072:2pmhs-24thioph-bala-betamethioph
5073:bim-24thioph-gly-aspaba
5074:ibhs-25methihz-gly-betatrif
5075:bhs-24thioph-gly-beta3quin
5076:ibhs-oxadiaz-gly-betatrif
105077:2py-triaz-bala-betapy
5078:phhs-24thioph-bala-betameph
5079:bim-25oxaz-gly-psdap
5080:tolhs-nme35pyr-bala-betabthioph
5081:tolhs-25thiaz-gly-betahmph
155082:bhs-42nmeim-ala-betapy
5083:tolhs-25oxaz-bala-beta34meoph
5084:ibhs-24thiaz-gly-betameph
5085:bim-me24thioph-bala-betadcph
5086:2py-26py-gly-betabiph
205087:ibhs-25thiaz-bala-betaheph
5088:bhs-25thiaz-nmgly-betadhbfu
5089:tolhs-oxadiaz-gly-betameph
5090:bhs-nme35pyr-nmgly-beta34meoph
5091:dhpyrr-24thiaz-gly-betapy
255092:tolhs-25oxaz-bala-betathioph
5093:bhs-24thiaz-bala-betaipro
5094:bhs-25oxaz-ala-betamesu
5095:ibhs-24thioph-gly-betathiobe
5096:nmhs-25methiaz-gly-betadcph
305097:phhs-24thiaz-gly-aspibua
5098:bhs-oxadiaz-gly-betapytb
5099:bim-24thiaz-bala-psdap
5100:ibhs-nme35pyr-bala-betabenfu
5101:ibhs-24thiaz-bala-betaomebendi
355102:ibhs-25thiaz-bala-betabnaphth
5103:2py-25oxaz-leu-betapy
5104:phhs-ithiadiaz-gly-aspbzla

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-164
5105:ibhs-25thiaz-bala-betabdimo
5106:2py-me24thioph-gly-betadcph
5107:tolhs-oxadiaz-bala-betaipro
5108:ibhs-24thiaz-bala-betahmph
5109:bhs-25thiaz-gly-aspaba
5110:2py-35thioph-ala-betapy
5111:bhs-24thioph-gly-zdaptb
5112:phhs-nme35pyr-gly-betatrif
5113:tolhs-25oxaz-gly-betaphethioa
5114:thazep-24thiaz-gly-betadcph
5115:tolhs-ithiadiaz-gly-betadcphch
5116:phhs-25oxaz-bala-betafbph
5117:tolhs-25methiaz-gly-betamethioph
5118:impy-24thiaz-gly-betambiph
5119:phhs-oxadiaz-bala-betafu3
5120:tolhs-me24thiaz-leu-zdap
5121:ibhs-ithiadiaz-bala-betabediox
5122:bhs-oxadiaz-gly-betahc
5123:tolhs-24thiaz-gly-betahmph
5124:bhs-oxadiaz-bala-zdap
5125:bhs-oxadiaz-bala-betahbcph
5126:bim-24thiaz-gly-psdap
5127:bhs-24thiaz-ala-betampy
5128:2pmhs-25oxaz-gly-beta35dbph
5129:bhs-26py-gly-betainyl
5130:bhs-nme35pyr-bala-betapym
5131:2py-26py-met-zdap
5132:ibhs-25oxaz-bala-betacthioph
5133:impy-24thioph-gly-betabthioph
5134:tolhs-oxadiaz-gly-betahdcph
5135:bhs-24thiaz-gly-betapych
5136:bhs-oxadiaz-ala-psdap
5137:phhs-24thiaz-gly-betadcphee
5138:phhs-oxadiaz-gly-betaibph
5139:ibhs-25oxaz-bala-betadhbfu
5140:ibhs-25thiaz-bala-betathiobe
5141:bhs-nme35pyr-ala-betadcph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-165-
5142:bhs-25oxaz-bala-betampy
5143:2py-26py-ala-betainyl
5144:tolhs-25oxaz-bala-beta13bendi
5145:tolhs-nme35pyr-bala-betahmo
5146:bhs-nme35pyr-gly-betadbph
5147:bim-me25thioph-bala-psdap
5148:bhs-25oxaz-ala-beta34dcph
5149:ibhs-nme35pyr-gly-zdaptb
5150:tolhs-25methiaz-bala-betamethi
5151:bhs-nme35pyr-gly-beta13bendi
5152:2py-me25thioph-leu-psdap
5153:ibhs-24thioph-bala-betatbuph
5154:sabhs-24thiaz-gly-psdap
5155:bhs-25thiaz-bala-betahmph
5156:bim-triaz-gly-betapy
5157:phhs-24thioph-bala-betamethioph
5158:phhs-nme35pyr-bala-psdaptb
5159:dhim-24py-gly-betameph
5160:cima-25thiaz-bala-psdap
5161:bhs-24thiaz-gly-betampy
5162:tolhs-25methiaz-bala-beta23meoph
5163:2py-ithiadiaz-ala-betapy
5164:impy-25methiaz-gly-betabthioph
5165:ibhs-24thioph-bala-betaoxope
5166:tolhs-me25thiaz-gly-beta34meoph
5167:ibhs-nme35pyr-gly-betamethi
5168:ibhs-nme35pyr-gly-betabpy
5169:tolhs-25methiaz-bala-betaph
5170:tolhs-24thioph-gly-betapyr
5171:ibhs-25oxaz-bala-betahph
5172:bim-24thiaz-bala-betafphe
5173:tolhs-me24thioph-gly-betadcph
5174:bhs-ithiadiaz-gly-psdapch
5175:2py-24thiaz-bala-betapy
5176:tolhs-nme35pyr-bala-betaipro
5177:bhs-24thioph-nmgly-beta23meoph
5178:bim-52thiaz-gly-betadcph

CA 02371604 2001-10-24
W000/66618 PCTIEP00103469
-166-
5179: gua-24oxaz-gly-betathioph
5180: bhs-triaz-gly-betadcph
5181: bim-42nmeim-bala-betaipr
5182: tolhs-25thiaz-gly-betapym
5183: phhs-25thiaz-bala-betadcphch
5184: phhs-ithiadiaz-gly-betafu2
5185: phhs-ithiadiaz-bala-betampy
5186: phhs-ithiadiaz-gly-betadcphtb
5187: dhim-26py-ala-betapy
5188:phhs-oxadiaz-gly-betamesu
5189: ibhs-25methiaz-bala-psdapee
5190: phhs-me24thioph-gly-zdap
5191: ibhs-25oxaz-gly-betadmph
5192: bhs-25methiaz-gly-betadcphee
5193:bim-oxadiaz-ala-psdap
5194: phhs-ithiadiaz-gly-betaamibe
5195: 2py-rne25oxaz-gly-betaph
5196: phhs-25oxaz-bala-aspaba
5197: bim-me25oxaz-leu-zdap
5198:2py-25thiaz-bala-betafluo
5199: ibhs-24thioph-gly-betafphe
5200: bim-25thiaz-bala-betapy
5201: bhs-24thioph-bala-betatos
5202: gua-25thiaz-gly-betabdimo
5203:2py-42oxaz-ala-betadcph
5204: bhs-ithiadiaz-gly-betamethioph
5205: tolhs-me25thioph-leu-betapy
5206: bhs-25thiaz-ala-psdap
5207: ibhs-25thiaz-bala-betaoxope
5208:bhs-25oxaz-bala-betahmph
5209: bhs-25thiaz-gly-betabthioph
5210: tolhs-24thioph-gly-betabenfu
5211: phhs-me25thioph-leu-betaph
5212: tolhs-25thiaz-gly-ibsdap
5213:phhs-24thioph-gly-betahni
5214: bhs-24thioph-gfy-betaipr
5215: tolhs-me25oxaz-ala-betapy

CA 02371604 2001-10-24
W000166618 ~ PCTIEP00103469
-167-
5216:phhs-me24thioph-bala-zdap
5217:bhs-25oxaz-bala-betathioph
5218:ibhs-ithiadiaz-gly-zdaptb
5219:ibhs-24thioph-bala-betahmo
5220:tolhs-25methiaz-gly-betabthioph
5221:tolhs-nme35pyr-gly-betaibph
5222:tolhs-me24thioph-gly-zdap
5223:phhs-24thiaz-gly-ibsdap
5224:tolhs-25thiaz-gly-betahbcph
5225:ibhs-oxadiaz-bala-betafph
5226:bhs-oxadiaz-nmgly-betahmph
5227:impy-42nmeim-bala-betameph
5228:gua-25thiaz-gly-betadcph
5229:phhs-oxadiaz-gly-betapym
5230:bhs-24thioph-gly-betabmph
5231:phhs-24thioph-gly-aspibua
5232:bhs-25oxaz-ala-betahph
5233:ibhs-24thiaz-gly-asppha
5234:2py-42oxaz-gly-zdap
5235:phhs-me24thiaz-gly-beta34meoph
5236:bhs-nme35pyr-bala-betamethi
5237:bhs-25oxaz-bala-betaheph
5238:dhim-25thiaz-ala-betameph
5239:bhs-ithiadiaz-gly-beta35dbph
5240:bim-oxadiaz-ala-betapy
5241:ibhs-nme35pyr-bala-betafu3
5242:phhs-ithiadiaz-gly-betabpy
5243:tolhs-ithiadiaz-gly-betah35dc
5244:2py-me25thiaz-ala-psdap
5245:bim-24im-ala-zdap
5246:bim-me25oxaz-gly-beta34meoph
5247:bhs-oxadiaz-bala-betapbiph
5248:bhs-24thioph-gly-beta4bph
5249:ibhs-25methiaz-bala-betaibph
5250:ibhs-24thiaz-gly-betatbuph
5251:bhs-oxadiaz-nmgly-betaanaphth
5252:phhs-25thiaz-gly-betamethi

CA 02371604 2001-10-24
W000166618 PGTIEP00103469
-168-
5253:ibhs-ithiadiaz-gly-betadcphtb
5254:tolhs-24thioph-bala-betaet
5255:bhs-25methiaz-bala-beta34meoph
5256:ibhs-25thiaz-bala-suabu
5257:2py-42nmeim-gly-betapy
5258:tolhs-25thiaz-bala-betahmph
5259:bhs-25thiaz-gly-betahni
5260:2pmhs-42nmeim-bala-betaphethio
5261:tolhs-25methiaz-gly-betadbph
5262:ibhs-25thiaz-gly-betamethioph
5263:bhs-25thiaz-nmala-betameph
5264:2py-25methiaz-ala-betadcph
5265:bim-35fur-gly-betadcph
5266:bhs-oxadiaz-gly-betabenfu
5267:2py-oxadiaz-gly-betadcph
5268:bhs-25oxaz-bala-betaph
5269:phhs-24thioph-gly-betamethioph
5270:phhs-oxadiaz-bala-betafu2
5271:bhs-25methiaz-gly-betaoxaz
5272:tolhs-25thiaz-bala-betacbph
5273:tolhs-25oxaz-gly-betah35dc
5274:ibhs-24thiaz-gly-aspaba
5275:bim-25oxaz-bala-aspbzla
5276:tolhs-oxadiaz-bala-betahmofu
5277:bhs-25oxaz-bala-csdap
5278:tolhs-oxadiaz-gly-zdaptb
5279:phhs-25thiaz-bala-beta34dcph
5280:phhs-24thioph-bala-betambiph
5281:tolhs-24thiaz-gly-betabthioph
5282:bhs-24thiaz-bala-betaomebendi
5283:phhs-25thiaz-bala-beta35dbph
5284:ibhs-25methiaz-bala-aspbzla
5285:bhs-24thioph-ala-beta23meoph
5286:bhs-nme35pyr-bala-csdap
5287:phhs-24thiaz-bala-betafu3
5288:ibhs-25methiaz-gly-betaimid
5289:ibhs-24thiaz-gly-betafph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-169
5290:impy-25oxaz-bala-betabenfu
5291;bhs-25thiaz-bala-suabu
5292:phhs-24thioph-gly-betabdimo
5293:tolhs-me24thioph-bala-psdap
5294:ibhs-24thioph-gly-betabenfu
5295:bim-35fur-ala-betapy
5296:bhs-25oxaz-bala-suabu
5297:bhs-25thiaz-bala-betamethi
5298:bhs-oxadiaz-bala-betabpy
5299:gua-24thiaz-gly-betaamibe
5300:bhs-25methiaz-bala-betathioph
5301:phhs-me25thiaz-gly-betadcph
5302:bhs-24thiaz-bala-ibsdap
5303:ibhs-25thiaz-bala-aspaba
5304:tolhs-ithiadiaz-bala-betaheph
5305:bhs-25oxaz-nmgly-betahph
5306:tolhs-24thioph-gly-betaol
5307:bhs-25methiaz-bala-betapych
5308:2py-42nmeim-bala-betaomebendi
5309:bhs-25methiaz-bala-betabthioph
5310:bhs-25thiaz-bala-betaimid
5311:tolhs-24thiaz-gly-betahb
5312:ibhs-ithiadiaz-bala-betacph
5313:ibhs-25oxaz-gly-asppha
5314:phhs-25thiaz-gly-betahdbph
5315;tolhs-ithiadiaz-g1y-betacthioph
5316:bhs-ithiadiaz-ala-beta13bendi
5317:tolhs-25oxaz-gly-betabph
5318:ibhs-25thiaz-bala-betaomebendi
5319:bhs-ithiadiaz-gly-ibsdap
5320:ibhs-24thiaz-gly-betapyee
5321:tolhs-24thioph-bala-betathiobe
5322:bhs-ithiadiaz-gly-betapyee
5323:ibhs-24thioph-gly-betadito
5324:bim-me24oxaz-leu-beta34meoph
5325:tolhs-24thiaz-bala-busu2be
5326:bhs-25thiaz-gly-betaoxaz

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-170-
5327: ibhs-nme35pyr-gly-aspaba
5328: ibhs-nme35pyr-bala-betatrif
5329: bhs-25oxaz-bala-betafph
5330: tolhs-25oxaz-bala-betacbph
5331; 2py-oxadiaz-ala-betadcph
5332: phhs-24thiaz-bala-busu2be
5333: tolhs-25methiaz-gly-betainyl
5334: phhs-nme35pyr-bala-betafu3
5335: bhs-24thiaz-gly-betaphethioa
5336: ibhs-25oxaz-gly-aspibua
5337: tolhs-24thiaz-gly-betaphethioa
5338: 2py-25methiaz-gly-beta35dbph
5339: ibhs-nme35pyr-gly-betahb
5340: 2py-25thiaz-bala-betadcph
5341; 2py-me24thioph-leu-zdap
5342: phhs-nme35pyr-gly-betaipr
5343: bhs-25oxaz-nmgiy-betacph
5344: tolhs-oxadiaz-bala-beta4bph
5345: bhs-24thioph-ala-betadcph
5346. phhs-25thiaz-gly-beta13bendi
5347: tolhs-oxadiaz-gly-suabu
5348: bhs-25oxaz-bala-betapyee
5349: tolhs-25thiaz-bala-aspbzla
5350: tolhs-24thiaz-gly-betahcbph
5351: ibhs-oxadiaz-bala-betatrif
5352: bhs-24thiaz-bala-zdap
5353: ibhs-ithiadiaz-bala-betapyee
5354: 2py-42nmeim-leu-betadcph
5355: bim-42pym-gly-betameph
5356: tolhs-25oxaz-gly-betafph
5357: phhs-25oxaz-bala-betahmo
5358: bhs-25thioph-ala-betainyl
5359: phhs-25methiaz-gly-betaftrif
5360: bim-25oxaz-bala-betapy
5361: ibhs-nme35pyr-gly-betaol
5362: 2py-25methiaz-gly-betatbuph
5363: bhs-25thiaz-bala-betadmoph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-171-
5364: tolhs-24thioph-bala-csdap
5365: ibhs-oxadiaz-gly-beta13bendi
5366: tolhs-nme35pyr-gly-betampy
5367: bhs-25oxaz-bala-betaoxaz
5368: bhs-nme35pyr-nmgly-betafphe
5369: tolhs-nme35pyr-bala-betadcph
5370: tolhs-nme35pyr-bala-betadmoph
5371: 2py-25thiaz-gly-betapy
5372: dhim-42pym-ala-betameph
5373:bhs-24thiaz-bala-betapy
5374: phhs-oxadiaz-bala-betaimid
5375: ibhs-ithiadiaz-gly-betahmph
5376: tolhs-24thioph-bala-zdapch
5377: 2py-24oxaz-ala-psdap
5378:ibhs-ithiadiaz-gly-betambiph
5379: bim-nme35pyr-bala-psdap
5380: bim-25fur-leu-betadcph
5381: bhs-oxadiaz-bala-psdap
5382: phhs-25methiaz-bala-betaipr
5383:bhs-me25thiaz-ala-zdap
5384: ibhs-ithiadiaz-bala-betameph
5385: bhs-25oxaz-gly-beta13bendi
5386: tolhs-nme35pyr-bala-betabdimo
5387: ibhs-oxadiaz-bala-betahc
5388:bhs-25oxaz-bala-beta34dcph
5389: ibhs-25thiaz-bala-betadhbfu
5390: bhs-25methiaz-gly-betatrif
5391: ibhs-24thiaz-bala-betafu2
5392: phhs-ithiadiaz-gly-betabediox
5393:bhs-me25thioph-gly-betapy
5394: bhs-me25oxaz-ala-betadcph
5395: bhs-24thiaz-gly-betaphethio
5396: tolhs-24thiaz-bala-betadtrif
5397: bhs-ithiadiaz-nmgly-betaanaphth
5398:phhs-24thiaz-bala-betadcphtb
5399: bhs-ithiadiaz-ala-betacph
5400: thpym-24thioph-bala-psdap

CA 02371604 2001-10-24
W000/66618 PCTIEP00/03469
-172-
5401:bhs-25oxaz-ala-betathioph
5402:bim-25methiaz-nmala-betadcph
5403:tolhs-25methiaz-gly-betahc
5404:bhs-25py-gly-betapy
5405:bim-me24thiaz-leu-zdap
5406:ibhs-oxadiaz-bala-betapyee
5407:phhs-me25oxaz-bala-betaph
5408:phhs-ithiadiaz-bala-betahmofu
5409:ibhs-25oxaz-bala-betafbph
105410:phhs-ithiadiaz-gly-betabmph
5411:phhs-25thiaz-gly-betabthioph
5412:ibhs-25methiaz-gly-aspibua
5413:tolhs-25thiaz-gly-psdapee
5414:bim-25thioph-ala-psdap
155415:bhs-ithiadiaz-nmgly-beta23meoph
5416:bhs-24thiaz-gly-betahb
5417:tolhs-25thiaz-gly-betamethi
5418:tolhs-oxadiaz-bala-betapych
5419:bim-25methiaz-ala-psdap
205420:bhs-me24oxaz-leu-betapy
5421:tolhs-25methiaz-gly-beta4bph
5422:dhim-26py-gly-betapy
5423:ibhs-oxadiaz-gly-asppha
5424:2py-24thiaz-leu-betadcph
255425:tolhs-oxadiaz-bala-betabmph
5426:bhs-oxadiaz-bala-betafu2
5427:bhs-25methiaz-bala-betaipro
5428:tolhs-25methiaz-gly-betapych
5429:phhs-25thiaz-bala-beta4bph
305430:bim-thiadiaz-leu-betadcph
5431:tolhs-24thiaz-gly-betabmph
5432:gua-42pym-gly-betaheph
5433:phhs-ithiadiaz-bala-betaipr
5434:2pmhs-25thiaz-bala-betapyr
355435:tolhs-me24thioph-leu-betadcph
543fi:bhs-oxadiaz-gly-betamethi
5437:phhs-24thiaz-bala-betathiome

CA 02371604 2001-10-24
WO00/66618 PCTIEP00103469
-173-
5438:ibhs-nme35pyr-bala-betamethioph
5439:tolhs-me24thiaz-ala-psdap
5440:tolhs-24thioph-gly-betadito
5441:bhs-24thiaz-bala-betahdcph
5442:phhs-24thiaz-gly-betathiobe
5443:bim-42pym-ala-betameph
5444:phhs-24thiaz-gly-zdaptb
5445:bhs-24thiaz-gly-csdap
5446:bhs-oxadiaz-bala-betadtrif
5447:2py-42oxaz-a(a-psdap
5448:phhs-oxadiaz-bala-beta4bph
5449:bhs-oxadiaz-gly-betahdbph
5450:gua-26py-gly-beta4bph
5451:bhs-26pyrazi-ala-betapy
5452:tolhs-24thiaz-gly-psdaptb
5453:bhs-42nmeim-gly-betaheph
5454:ibhs-ithiadiaz-bala-betatbuph
5455:ibhs-24thioph-bala-betatrif
5456:phhs-25methiaz-gly-betaph
5457:bim-me24thioph-bala-zdap
5458:ibhs-oxadiaz-bala-betabthioph
5459:bhs-me24oxaz-leu-psdap
5460:tolhs-24thiaz-gly-betapych
5461:phhs-25thiaz-gly-betaol
5462:bhs-me24im-gly-zdap
5463:bim-25oxaz-gly-betathiome
5464:impy-25oxaz-bala-betaamibe
5465:tolhs-25methiaz-bala-asppha
5466:ibhs-24thioph-bala-betahdcph
5467:ibhs-25methiaz-bala-busu2be
5468:bhs-24thiaz-bala-betabmph
5469:bhs-me25thioph-gly-psdap
5470:ibhs-24thiaz-bala-betafluo
5471:dhim-24thiaz-ala-betapy
5472:bim-25thioph-leu-betadcph
5473:thpym-24thiaz-bala-psdap
5474:bhs-25oxaz-bala-betameph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-174-
5475: bhs-24thiaz-gly-betaoxaz
5476: bim-24thiaz-ala-psdap
5477: phhs-24thiaz-bala-betaoxaz
5478: bhs-ithiadiaz-bala-betahb
5479:bhs-ithiadiaz-bala-zdapee
5480; bhs-25oxaz-nmgly-betaoxaz
5481: bhs-25thiaz-nmgly-betadito
5482: bhs-nme35pyr-gly-psdapch
5483: ibhs-nme35pyr-gly-betadbph
5484:phhs-me24oxaz-leu-zdap
5485: bhs-oxadiaz-bala-betaoxaz
5486: bhs-oxadiaz-gly-betadito
5487: gua-42pym-gly-betathiobe
5488: bim-42nmeim-ala-betadcph
5489:bhs-42nmeim-gly-betabnaphth
5490: phhs-ithiadiaz-bala-betapytb
5491: 2py-ithiadiaz-bala-aspbzla
5492: bhs-24thioph-gly-betafbph
5493: bhs-oxadiaz-bala-betaanaphth
5494:bhs-me24oxaz-bala-betaph
5495: phhs-25thiaz-bala-betacthioph
5496: tolhs-25methiaz-bala-betapyee
5497: bhs-25methiaz-gly-beta35dbph
5498: phhs-me24oxaz-gly-betapy
5499:ibhs-25methiaz-bala-betaph
5500: 2py-24oxaz-bala-betapy
5501: ibhs-ithiadiaz-gly-aspibua
5502: phhs-25thiaz-gly-betadcphee
5503: bhs-24pym-gly-zdap
5504:tolhs-24thiaz-gly-betathioph
5505: tolhs-ithiadiaz-bala-betadcphch
5506: 2py-ithiadiaz-leu-betadcph
5507: phhs-24thiaz-bala-betapyee
5508: phhs-ithiadiaz-bala-betadcph
5509:bhs-25oxaz-bafa-betamethioph
5510: 2py-53pyrazo-leu-betapy
5511: ibhs-25oxaz-gly-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-175
5512:ibhs-oxadiaz-gly-csdap
5513:bim-25methiaz-ala-betadcph
5514:phhs-25methiaz-bala-betamethioph
5515:bhs-oxadiaz-bala-psdaptb
5516:2py-me25thiaz-gly-betapy
5517:tolhs-25thiaz-gly-betacph
5518:impy-42nmeim-gly-betapyr
5519:bim-25methiaz-bala-betafphe
5520:phhs-25oxaz-gly-betapytb
5521:ibhs-25oxaz-gly-betapbiph
5522:2py-me25oxaz-bala-psdap
5523:bhs-ithiadiaz-bala-zdaptb
5524:2py-25methiaz-bafa-betafluo
5525:bhs-25thiaz-gly-betacthioph
5526:bhs-nme35pyr-bala-beta35dbph
5527:bhs-25oxaz-bala-betadcph
5528:tolhs-25thiaz-gly-betahdbph
5529:phhs-25thiaz-bala-betafph
5530:bhs-25thiaz-bala-betahdcph
5531:bhs-ithiadiaz-gly-betafu3
5532:bhs-25thiaz-bala-betapym
5533:bhs-ithiadiaz-ala-beta23meoph
5534:ibhs-nme35pyr-bala-betapych
5535:bhs-me25oxaz-bala-betapy
5536:2py-nme35pyr-bala-asppha
5537:2py-35thioph-bala-betapy
5538:phhs-nme35pyr-bala-betadcphee
5539:tolhs-25oxaz-bala-betabpy
5540:bhs-24thioph-bala-betacthioph
5541:bhs-24thioph-ala-betabpy
5542:bim-24im-leu-betadcph
5543:bhs-oxadiaz-gly-betamesu
5544:bhs-thiadiaz-gly-betadcph
5545:tolhs-25thiaz-bala-betameph
5546:bhs-thiadiaz-ala-psdap
5547:bhs-24thioph-bala-betadcphch
5548:bhs-ithiadiaz-gly-betabenfu

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-176
5549:ibhs-nme35pyr-bala-betadcphee
5550:bhs-me25oxaz-leu-betaph
5551:bhs-me24thiaz-leu-betadcph
5552:tolhs-25thiaz-gly-betatbuph
5553:gua-25thioph-gly-betacbph
5554:phhs-25methiaz-gly-betahph
5555:2py-me25thiaz-bala-psdap
5556:bhs-25methiaz-nmgly-betabpy
5557:bhs-oxadiaz-nmgly-betameph
5558:tolhs-24thiaz-gly-betacthioph
5559:dimethpyin-24thioph-gly-betameph
5560:ibhs-25oxaz-bala-betameph
5561:bhs-24thioph-bala-aspbzla
5562:ibhs-24thioph-bala-betabediox
5563:tolhs-25oxaz-bala-betaphethioa
5564:ibhs-24thiaz-gly-betabpy
5565:tolhs-25oxaz-bala-betacthioph
5566:tolhs-24thioph-bala-betapbiph
5567:ibhs-oxadiaz-bala-betahbcph
5568:phhs-oxadiaz-bala-betatrif
5569:bhs-25oxaz-bala-betabmph
5570:ibhs-oxadiaz-gly-betameph
5571:phhs-ithiadiaz-bala-betathiome
5572:tolhs-ithiadiaz-bala-betacthioph
5573:phhs-24thiaz-bala-betaftrif
5574:ibhs-ithiadiaz-bala-betamethi
5575:ibhs-ithiadiaz-gly-betabenfu
5576:ibhs-24thioph-gly-betahdcph
5577:phhs-me25thioph-bala-betaph
5578:2py-oxadiaz-gly-aspbzla
5579:bhs-24thiaz-nmgly-betameph
5580:tolhs-oxadiaz-bala-betadtrif
5581:bhs-oxadiaz-bala-beta3quin
5582:hs-25thioph-gly-betapy
5583:2py-53pyrazo-gly-betapy
5584:bhs-me25thiaz-leu-beta34meoph
5585:bgua-25thiaz-gly-betapy

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-177-
5586:tolhs-nme35pyr-gly-betahni
5587:tolhs-25thiaz-gly-betafphe
5588:bhs-ithiadiaz-bala-csdap
5589:dhim-24thiaz-gly-betadtrif
5590:bim-24thiaz-bala-aspaba
5591:phhs-25thiaz-bala-betaheph
5592:bhs-24thiaz-gly-beta13bendi
5593:ibhs-25oxaz-bala-betathioph
5594:phhs-25methiaz-gly-betafu3
5595:tolhs-ithiadiaz-gly-betamethioph
5596:2py-42nmeim-gly-betatos
5597:ibhs-25oxaz-bala-betapyr
5598:ibhs-nme35pyr-bala-betamethi
5599:bhs-24thioph-bala-betaheph
5600:ibhs-24thiaz-bala-betadcphtb
5601:phhs-25thiaz-gly-betaheph
5602:ibhs-nme35pyr-bala-betaphethio
5603:ibhs-25methiaz-gly-betathio3
5604:tolhs-nme35pyr-gly-betaol
5605:tolhs-24thioph-gly-suabu
5606:bhs-25oxaz-gly-beta35dbph
5607:tolhs-24thiaz-giy-aspbzla
5608:bhs-24thioph-nmgly-betameph
5609:tolhs-ithiadiaz-bala-betahni
5610:bhs-25oxaz-gly-busu2be
5611:phhs-me25thioph-gly-beta34meoph
5612:bhs-24thiaz-gly-betadcphtb
5613:bim-26py-gly-betapy
5614:2py-me24thiaz-ala-betaph
5615:2py-me24oxaz-bala-betadcph
5616:bhs-25methiaz-gly-betahni
5617:bhs-25methiaz-gly-betabph
5618:bhs-24thiaz-bala-betafphe
5619:tolhs-ithiadiaz-bala-betafbph
5620:ibhs-oxadiaz-gly-betahc
5621:phhs-nme35pyr-baia-betabmph
5622:bhs-25methiaz-bala-betaimid

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-178-
5623: tolhs-oxadiaz-bala-betadbph
5624: bhs-25methiaz-gly-beta34dcph
5625: bhs-ithiadiaz-nmgly-betainyl
5626: bhs-25methiaz-gly-zdap
5627: gua-25thioph-gly-beta13bendi
5628: phhs-24thiaz-bala-betaibph
5629: bhs-24thioph-bala-betamethi
5630: bim-me24oxaz-ala-betapy
5631: phhs-24thioph-bala-betahmo
5632:ibhs-24thioph-gly-betahmo
5633: tolhs-oxadiaz-bala-betafph
5634: ibhs-25oxaz-gly-betafluo
5635: phhs-25thiaz-gly-betaipro
5636: 2py-thiadiaz-ala-zdap
5637:tolhs-ithiadiaz-gly-betadcphtb
5638: ibhs-25thiaz-bala-betahb
5639: phhs-me24thioph-gly-betaph
5640: phhs-oxadiaz-gly-betapy
5641: tolhs-nme35pyr-gly-betathio3
5642:bhs-25methiaz-gly-betafphe
5643: bhs-nme35pyr-bala-betatrif
5644: phhs-nme35pyr-bala-betaheph
5645: bim-25thiaz-bala-asppha
5646: 2py-25thiaz-bala-beta34dcph
5647:bhs-24thiaz-gly-suabu
5648: ibhs-24thioph-bala-betafbph
5649: tolhs-25thiaz-bala-zdapee
5650: tolhs-ithiadiaz-bala-ibsdap
5651: bhs-25methiaz-gly-betaphethio
5652:ibhs-25oxaz-gly-betapym
5653: phhs-25oxaz-bala-betahb
5654: ibhs-ithiadiaz-gly-betainyl
5655: tolhs-me24thiaz-leu-psdap
5656; ibhs-25oxaz-bala-betathio3
5657:2py-53pyrazo-leu-psdap
5658: tolhs-nme35pyr-bala-betacph
5659: ibhs-25thiaz-bala-betafu2

CA 02371604 2001-10-24
WOOOIfi6618 PCTIEP00103469
-179
5660: ibhs-25methiaz-gly-betadcphch
5661: bhs-me24oxaz-ala-zdap
5662: phhs-24thiaz-bala-beta34meoph
5663: tolhs-nme35pyr-bala-betathiobe
5664: phhs-me24thioph-gly-psdap
5665: tolhs-25oxaz-gly-betabpy
5666: 2py-25oxaz-gly-asppha
5667: ibhs-25methiaz-gly-betacbph
5668: bhs-25methiaz-bala-beta3quin
5669:tolhs-24thioph-gly-beta23meoph
5670: tolhs-nme35pyr-gly-betahcbph
5671: ibhs-25thiaz-bala-betaphethioa
5672: phhs-nme35pyr-gly-betafphe
5673: bhs-ithiadiaz-gly-betabediox
5674:ibhs-24thiaz-gly-betahdbph
5675: tolhs-25methiaz-bala-betathioph
5676: tolhs-nme35pyr-bala-betamethi
5677: tolhs-25thiaz-gly-betabenfu
5678: gua-24thiaz-gly-betabdimo
5679:phhs-24thiaz-bala-psdapee
5680: phhs-oxadiaz-gly-psdapch
5681: phhs-25oxaz-gly-betahdcph
5682: ibhs-24thioph-bala-betapym
5683: tolhs-25thiaz-gly-betahb
5684:bhs-42nmeim-gly-betaet
5685: bim-me25thioph-ala-betapy
5686: bim-25thiaz-leu-betadcph
5687: bhs-25thiaz-bala-betapyee
5688: ibhs-25methiaz-bala-betahmo
5689:phhs-25oxaz-gly-betacbph
5690: dhim-42pym-ala-zdap
5691: bhs-oxadiaz-gly-betathioph
5692: tolhs-25oxaz-gly-betahmo
5693: phhs-24thiaz-gly-betaipr
5694:tolhs-me24oxaz-leu-betapy
5695: phhs-oxadiaz-gly-betapytb
5696: ibhs-25methiaz-gly-beta35dbph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-180
5697:bhs-ithiadiaz-gly-betadhbfu
5698:phhs-25thiaz-gly-busu2be
5699:bhs-nme35pyr-bala-betambiph
5700:bim-24thioph-gly-betapy
5701:ibhs-nme35pyr-gly-betadcphtb
5702:bim-25methiaz-gly-psdap
5703:phhs-nme35pyr-bala-betaipr
5704:gua-25thiaz-gly-betainyl
5705:bhs-25oxaz-bala-betafluo
105706:gua-25thioph-gly-betahmph
5707:tolhs-24thioph-gly-betainyl
5708:bhs-24thioph-bala-betaet
5709:tolhs-25oxaz-bala-betafu3
5710:2py-24thiaz-bala-beta34dcph
155711:gua-42pym-gly-betaph
5712:tolhs-ithiadiaz-gly-betahni
5713:2py-42nmeim-leu-psdap
5714:2py-24thiaz-hphe-psdap
5715:phhs-nme35pyr-gly-zdapee
205716:bhs-26py-ala-betapy
5717:ibhs-25methiaz-gly-betabph
5718:bhs-25methiaz-bala-betaphethioa
5719:tolhs-me25thiaz-aia-zdap
5720:bhs-24thioph-bala-beta3quin
255721:dhim-25thioph-ala-betainyl
5722:phhs-oxadiaz-gly-betahph
5723:tolhs-25oxaz-gly-betatbuph
5724:bhs-oxadiaz-gly-betaphethio
5725:bim-me24oxaz-ala-betaph
305726:tolhs-me25thiaz-leu-beta34meoph
5727:bim-24im-bala-betapy
5728:phhs-ithiadiaz-bala-betahb
5729:tolhs-25methiaz-gly-beta35dbph
5730:ibhs-25thiaz-bala-betadcphee
355731:ibhs-oxadiaz-bala-beta23meoph
5732:gua-24oxaz-gly-betatrif
5733:2py-25thioph-ala-zdap

CA 02371604 2001-10-24
WOOOI6661 g PCTIEPOOI03469
-181
5734: bhs-42oxaz-leu-betadcph
5735: bhs-triaz-bala-betapy
5736: phhs-25methiaz-bala-beta34dcph
5737: tolhs-ithiadiaz-gly-betabediox
5738: phhs-oxadiaz-bala-beta13bendi
5739: ibhs-25thiaz-bala-betahmo
5740: tolhs-25methiaz-bala-betadhbfu
5741: 2py-me24oxaz-leu-betapy
5742: phhs-ithiadiaz-bala-betafluo
105743: tolhs-24thioph-bala-betathiome
5744: bhs-52thiaz-gly-psdap
5745: tolhs-oxadiaz-gly-betabediox
5746: bhs-ithiadiaz-ala-betabnaphth
5747: phhs-oxadiaz-bala-betaamibe
155748: ibhs-oxadiaz-bala-betadcphch
5749: phhs-24thioph-bala-betafu2
5750: bhs-itbiadiaz-bala-betaoxope
5751: phhs-25oxaz-gly-betaoxaz
5752: ibhs-oxadiaz-bala-betaphethio
205753: bhs-25methiaz-nmgly-beta34meoph
5754: bhs-nme35pyr-gly-betadcph
5755: 2py-24oxaz-gly-betapy
5756: tolhs-25thiaz-bala-psdapch
5757: bhs-25thiaz-bala-betaoxaz
255758: bhs-24oxaz-gly-betameph
5759: bhs-24thioph-ala-betathioph
5760: ibhs-25oxaz-bala-betaipro
5761: phhs-ithiadiaz-bala-betambiph
5762: phhs-24thioph-bala-betaibph
305763: ibhs-ithiadiaz-bala-betadito
5764: tolhs-ithiadiaz-bala-betadcphee
5765: tolhs-oxadiaz-gly-aspbzla
5766: phhs-nme35pyr-gly-betaoxaz
57F7: bhs-42nmeim-gly-beta34dcph
355768: ibhs-oxadiaz-gly-betadito
5769: bhs-nme35pyr-gly-betahbcph
5770: tolhs-24thioph-bala-betamethioph

CA 02371604 2001-10-24
W000166618 PCTlEP00J03469
-182
5771:bhs-25methiaz-gly-beta23meoph
5772:bhs-25methiaz-ala-betahmph
5773:ibhs-25methiaz-bala-betadcphtb
5774:tolhs-24thioph-gly-betadbph
5775:tolhs-ithiadiaz-bala-betaet
5776:ibhs-ithiadiaz-gly-beta3quin
5777:2pm hs-42n meim-met-betapy
5778:ibhs-24thioph-gly-betafph
5779:ibhs-ithiadiaz-gly-betadbph
5780:phhs-25thiaz-bala-beta34meoph
5781:phhs-25oxaz-bala-betamesu
5782:bim-24thiaz-bala-betampy
5783:ibhs-25methiaz-bala-beta34meoph
5784:phhs-oxadiaz-gly-aspibua
5785:2py-me24oxaz-bala-betaph
5786:bhs-24im-leu-betapy
5787:ibhs-25thiaz-gly-betampy
5788:2py-me24thiaz-gly-beta34meoph
5789:ibhs-25methiaz-bala-zdaptb
5790:gua-42pym-gly-betapym
5791:phhs-nme35pyr-bala-psdapee
5792:phhs-oxadiaz-bala-betahph
5793:bhs-35fur-bala-zdap
5794:tolhs-25thiaz-bala-psdaptb
5795:tolhs-25thiaz-gly-betabph
5796:phhs-24thioph-bala-betaftrif
5797:ibhs-oxadiaz-gly-betamethi
5798:phhs-oxadiaz-bala-ibsdap
5799:ibhs-24thioph-bala-aspbzla
5800:bim-me25thioph-ala-betadcph
5801:bhs-24pym-ala-betameph
5802:phhs-me25oxaz-ala-psdap
5803:tolhs-24thioph-bala-betacthioph
5804:2py-24thiaz-gly-betadcph
5805:phhs-25thiaz-bala-betadtrif
5806:phhs-me25thioph-leu-zdap
5807:bhs-42nmeim-bala-zdap

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-183
5808:ibhs-oxadiaz-gly-betadmph
5809:phhs-25oxaz-bala-aspibua
5810:bim-thiadiaz-gly-betapy
5811:tolhs-25methiaz-gly-betadcphch
5812:ibhs-nme35pyr-bala-betahcbph
5813:bhs-25methiaz-bala-suabu
5814:tolhs-25oxaz-bala-betadbph
5815:phhs-ithiadiaz-gly-betaoxaz
5816:bhs-nme35pyr-bala-asppha
5817:tolhs-24thioph-gly-betahb
5818:bim-me25thioph-ala-psdap
5819:gua-24oxaz-gly-zdap
5820:phhs-25thiaz-gly-betabdimo
5821:phhs-25thiaz-gly-aspaba
5822:bhs-53pyrazo-bala-psdap
5823:2py-42nmeim-leu-zdap
5824:phhs-oxadiaz-gly-betadcphee
5825:imhs-25thiaz-gly-zdap
5826:phhs-25thiaz-bala-aspaba
5827:phhs-25methiaz-gly-betadhbfu
5828:bhs-24thiaz-bala-beta34meoph
5829:bhs-24thiaz-gly-betahmph
5830:2py-me25oxaz-bala-betaph
5831:hyd-42nmeim-bala-betadcph
5832:bhs-25thiaz-bala-beta3quin
5833:ibhs-ithiadiaz-bala-betabph
5834:ibhs-24thiaz-gly-betapbiph
5835:2py-25methiaz-bala-betadcph
5836:2py-25oxaz-leu-psdap
5837:tolhs-oxadiaz-gly-psdapch
5838:bhs-24thioph-ala-zdap
5839:bhs-24thioph-bala-betapych
5840:phhs-25thiaz-bala-betadcph
5841:bgua-42pym-gly-betapy
5842:bhs-25methiaz-nmgly-betacph
5843:impy-25oxaz-bala-betafbph
5844:phhs-24thiaz-gly-betadcphch

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-184
5845:phhs-25methiaz-bala-betaimid
5846:ibhs-25methiaz-bala-betahmofu
5847:ibhs-24thiaz-bala-betafbph
5848:ibhs-24thiaz-gly-busu2be
5849:2py-24thioph-hphe-psdap
5850:2py-me24thiaz-leu-beta34meoph
5851:phhs-24thiaz-gly-betaet
5852:phhs-25thiaz-gly-betameph
5853:ibhs-25methiaz-bala-betathiome
5854:tolhs-oxadiaz-bala-betacph
5855:ibhs-nme35pyr-gly-psdaptb
5856:bim-oxadiaz-bala-aspaba
5857:bim-24oxaz-gly-betainyl
5858:bhs-nme35pyr-gly-betaimid
5859:ibhs-25thiaz-bala-betahph
5860:2py-25thiaz-gly-betameph
5861:phhs-24thioph-gly-busu2be
5862:tolhs-25oxaz-gly-betaol
5863:bhs-24thioph-ala-betafphe
5864:bhs-25thiaz-nmgly-betadmoph
5865:ibhs-oxadiaz-bala-aspbzla
5866:bhs-ithiadiaz-bala-betacbph
5867:bim-35fur-ala-psdap
5868:tolhs-25thiaz-gly-betathiome
5869:tolhs-nme35pyr-gly-betahmofu
5870:ibhs-25methiaz-gly-betaibph
5871:tolhs-25thiaz-bala-betapytb
5872:impy-25oxaz-gly-betaphethio
5873:gua-24oxaz-gly-betabthioph
5874:gua-24thiaz-gly-betahcbph
5875:tolhs-nme35pyr-gly-betapym
5876:bim-me24thiaz-leu-betaph
5877:pahs-24thioph-bala-betameph
5878:bim-25thiaz-gly-betahmph
5879:bhs-25thiaz-gly-betabediox
5880:bhs-24thiaz-gly-betathiobe
5881:gua-42pym-nmgly-betapy

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-185
5882:gua-24thiaz-gly-betaipr
5883:tolhs-25thiaz-bala-psdap
5884:gua-24thiaz-gly-busu2be
5885:bhs-24thiaz-ala-betaoxaz
5886:tolhs-oxadiaz-bala-betabpy
5887:bhs-24thiaz-gly-betapbiph
5888:bhs-me24oxaz-gly-beta34meoph
5889:bhs-24thioph-bala-betaoxaz
5890:tolhs-ithiadiaz-gly-betahmph
5891:phhs-25methiaz-bala-busu2be
5892:bhs-24im-leu-zdap
5893:bhs-24thioph-bala-betabpy
5894:bhs-25methiaz-bala-betabpy
5895:ihhs-25oxaz-bala-betadcphtb
5896:bhs-25methiaz-gly-ibsdap
5897:phhs-24thiaz-bala-betathioph
5898:phhs-25methiaz-bala-zdap
5899:ibhs-25oxaz-gly-betaamibe
5900:imhs-24thioph-gly-zdap
5901:phhs-oxadiaz-gly-betafluo
5902:2py-26py-ala-betadcph
5903:2py-me25thioph-leu-betaph
5904:tolhs-25methiaz-gly-betaoxope
5905:phhs-ithiadiaz-bala-betaol
5906:tolhs-24thiaz-gly-betadtrif
5907:bhs-25methiaz-gly-psdapee
5908:bhs-ithiadiaz-gly-beta23meoph
5909:bhs-me24thiaz-gly-zdap
5910:2pmhs-25methiaz-gly-betafph
5911:bhs-25oxaz-bala-betadtrif
5912:bhs-25methiaz-bala-betatos
5913:bim-24thioph-bala-psdap
5914:tolhs-nme35pyr-bala-betafbph
5915:tolhs-24thiaz-bala-aspaba
5916:2py-triaz-gly-betadcph
5917:ibhs-24thiaz-gly-betahph
5918:tolhs-nme35pyr-gly-beta4bph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-186
5919:tolhs-ithiadiaz-bala-beta4bph
5920:phhs-25oxaz-gly-betadcph
5921:phhs-25methiaz-bala-betadmoph
5922:phhs-oxadiaz-gly-csdap
5923:tolhs-oxadiaz-bala-betadmph
5924:impy-42nmeim-bala-betahbcph
5925:tolhs-24thioph-gly-csdap
5926:ibhs-24thioph-bala-betabmph
5927:bhs-ithiadiaz-bala-betapyr
105928:tolhs-25thiaz-gly-betathiobe
5929:bhs-nme35pyr-bala-betabpy
5930:phhs-oxadiaz-gly-betadmph
5931:tolhs-24thiaz-bala-betadcphch
5932:dhim-25thioph-ala-betameph
155933:bhs-24thioph-bala-betaomebendi
5934:phhs-25oxaz-bala-betadmph
5935:bim-me24oxaz-leu-betapy
5936:bhs-oxadiaz-gly-betainyl
5937:tolhs-oxadiaz-gly-betaanaphth
205938:tolhs-24thioph-bala-betabph
5939:phhs-25thiaz-bala-betambiph
5940:bhs-me25oxaz-bala-zdap
5941:2pmhs-25oxaz-bala-betaet
5942:phhs-24thioph-gly-betahph
255943:bhs-oxadiaz-gly-betadtrif
5944:2py-oxadiaz-leu-betapy
5945:bhs-nme35pyr-bala-betaheph
5946:bim-25fur-gly-betapy
5947:bhs-25methiaz-gly-betaoxope
305948:tolhs-25oxaz-gly-betatrif
5949:dhthi-25oxaz-gly-zdap
5950:bhs-oxadiaz-nmgly-beta23meoph
5951:tolhs-25oxaz-gly-betaibph
5952:phhs-24thiaz-bala-betaanaphth
355953:bim-24thiaz-bala-betacph
5954:2py-42nmeim-bala-betadcph
5955:ibhs-25thiaz-gly-psdapee

CA 02371604 2001-10-24
WO00I66618 PCTlEP00103469
-187
5956:bhs-ithiadiaz-nmgly-beta3quin
5957:tolhs-24thioph-gly-betaheph
5958:bhs-ithiadiaz-ala-beta34meoph
5959:phhs-25oxaz-bala-csdap
5960:tolhs-ithiadiaz-gly-betabenfu
5961:ibhs-ithiadiaz-gly-betafu3
5962:bhs-26py-ala-betainyl
5963:bim-me25thioph-ala-zdap
5964:phhs-nme35pyr-bala-aspibua
5965:phhs-ithiadiaz-bala-zdap
5966:ibhs-oxadiaz-bala-betadcphee
5967:tolhs-oxadiaz-gly-betathioph
5968:impy-25methiaz-bala-busu2be
5969:bhs-ithiadiaz-bala-suabu
5970:bhs-nme35pyr-nmgly-betacthioph
5971:bhs-35fur-bala-psdap
5972:bhs-24thiaz-bala-betaftrif
5973:bhs-25oxaz-gly-betafbph
5974:tolhs-25thiaz-gly-betaibph
5975:2py-me24thiaz-gly-betadcph
5976:2py-me24oxaz-bala-psdap
5977:bim-ithiadiaz-ala-betadcph
5978:2py-25thiaz-gly-betaol
5979:phhs-25oxaz-bala-zdapee
5980:tolhs-25thiaz-bala-beta23meoph
5981:bhs-25thiaz-gly-betahbcph
5982:ibhs-oxadiaz-gly-betahmofu
5983:ibhs-ithiadiaz-gly-betahbcph
5984:2py-25thiaz-bala-betahni
5985:tolhs-24thiaz-bala-betaipr
5986:2py-25thioph-ala-betapy
5987:ibhs-oxadiaz-gly-betabthioph
5988:ibhs-25methiaz-gly-betapym
5989:2py-24thiaz-bala-betadcph
5990:phhs-me25thioph-leu-betadcph
5991:ibhs-24thioph-gly-betainyl
5992:phhs-24thiaz-bala-betatbuph

CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-188
5993: tolhs-oxadiaz-bala-psdaptb
5994: dhim-24oxaz-ala-betapy
5995: ibhs-25methiaz-bala-betafluo
5996: gua-26py-gly-betahph
5997:phhs-25thiaz-bala-psdapee
5998: phhs-24thiaz-gly-betaol
5999: bhs-25methiaz-bala-betaol
6000: 2py-nme35pyr-gly-aspibua
6001: ibhs-25oxaz-gly-beta35dbph
6002:tolhs-nme35pyr-gly-betahb
6003: ibhs-nme35pyr-gly-betaheph
6004: bhs-25oxaz-nmgly-betamesu
6005: 2py-24oxaz-ala-betadcph
6006: ibhs-ithiadiaz-gly-betaamibe
6007:tolhs-24thioph-gly-betadcphee
6008: tolhs-25thiaz-bala-asppha
6009: bhs-24thioph-bala-betadhbfu
6010: ibhs-ithiadiaz-bala-betadbph
6011: phhs-oxadiaz-gly-betathio3
6012:bhs-nme35pyr-nmgly-ibsdap
6013: ibhs-24thiaz-gly-betamethioph
6014: ibhs-oxadiaz-bala-betathio3
6015: 2py-25oxaz-nmgly-betadcph
6016: 2py-42n meim-gly-betahcbph
6017:toihs-24thioph-gly-betahdbph
6018: ibhs-nme35pyr-gly-betahdbph
6019: ibhs-24thiaz-gly-betabthioph
6020: bhs-25oxaz-bala-betapym
6021: ibhs-25methiaz-bala-betadito
6022:bhs-25thiaz-gly-betapbiph
6023: bhs-ithiadiaz-gly-betaibph
6024: ibhs-24thiaz-gly-betahni
6025: phhs-25oxaz-bala-betameph
6026: 2py-ith iadiaz-gly-aspbzla
6027:bhs-25methiaz-gly-betathiome
6028: phhs-ithiadiaz-gly-betahdcph
6029: tolhs-nme35pyr-bala-betaheph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-189
6030:tolhs-25thiaz-bala-betabph
6031:phhs-nme35pyr-bala-betatos
6032:phhs-me25thiaz-gly-beta34meoph
6033:tolhs-25methiaz-gly-betatrif
6034:tolhs-nme35pyr-gly-betacbph
6035:bim-25oxaz-gly-aspaba
6036:bhs-nme35pyr-bala-betabnaphth
6037:ibhs-24thioph-bala-betainyl
6038:phhs-ithiadiaz-gly-betaibph
6039:tolhs-nme35pyr-gly-betaftrif
6040:ur-25thiaz-gly-betainyl
6041:bim-oxadiaz-leu-betadcph
6042:phhs-oxadiaz-gly-betaipr
6043:tolhs-25thiaz-bala-betafphe
6044:cima-24thiaz-gly-betainyl
6045:ibhs-25oxaz-gly-csdap
6046:bhs-25oxaz-bala-betathio3
6047:phhs-me25thioph-gly-betapy
6048:tolhs-me24thiaz-gly-beta34meoph
6049:bim-25oxaz-phe-betapy
6050:tolhs-25thiaz-bala-betaphethio
6051:dhim-24thiaz-ala-betainyl
6052:tolhs-oxadiaz-bala-betaet
6053:tolhs-me24thiaz-ala-zdap
6054:tolhs-25oxaz-bala-betatos
6055:ibhs-24thiaz-gly-betatrif
6056:tolhs-oxadiaz-gly-betahbcph
6057:ibhs-25oxaz-gly-betaol
6058:2py-triaz-leu-psdap
6059:phhs-nme35pyr-gly-betahmofu
6060:bhs-ithiadiaz-bala-betafphe
6061:phhs-nme35pyr-gly-busu2be
6062:tolhs-me25thioph-leu-psdap
6063:thazep-42pym-gly-betapy
6064:ibhs-oxadiaz-bala-beta13bendi
6065:tolhs-25thiaz-gly-betafu3
6066:ibhs-oxadiaz-gly-betacbph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-190
6067:gua-25thiaz-gly-betabpy
6068:phhs-nme35pyr-bala-csdap
6069:bim-53py~azo-gly-psdap
6070:ibhs-ithiadiaz-bala-betaimid
6071:bhs-52thiaz-ala-zdap
6072:ibhs-24thiaz-bala-betaheph
6073:tolhs-25oxaz-gly-betatos
6074:2py-24oxaz-bala-betadcph
6075:bhs-35thioph-leu-zdap
6076:bhs-ithiadiaz-bala-zdapch
6077:bhs-24thioph-nmgly-betaanaphth
6078:tolhs-25methiaz-gly-psdap
6079.bhs-me24oxaz-ala-betapy
6080:ibhs-25methiaz-gly-betadhbfu
6081:bhs-25thiaz-bala-ibsdap
6082:tolhs-nme35pyr-gly-betahdbph
6083:2py-42nmeim-bala-betaibph
6084:phhs-24thiaz-gly-betadbph
6085:phhs-25oxaz-bala-betafphe
6086:2py-26py-gly-zdap
6087:tolhs-oxadiaz-gly-betabthioph
6088:tolhs-25oxaz-bala-betadtrif
6089:bim-me25oxaz-leu-betaph
6090:ibhs-ithiadiaz-bala-beta34meoph
6091:phhs-nme35pyr-gly-zdaptb
6092:ibhs-24thiaz-bala-aspibua
6093:tolhs-24thioph-gly-betabpy
6094:bhs-ithiadiaz-gly-betadmoph
6095:gua-24thiaz-gly-betaphethio
6096:phhs-oxadiaz-bala-betadtrif
6097:ibhs-24thioph-bala-asppha
6098:phhs-nme35pyr-gly-betacthioph
6099:tolhs-25methiaz-bala-betaanaphth
6100:bhs-ithiadiaz-gly-betadcphch
6101:bhs-25methiaz-bala-betahni
6102:bhs-24thiaz-gly-psdapch
6103:bim-42nmeim-leu-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEPOOl03469
-191-
6104:tolhs-24thioph-bala-beta34meoph
6105:tolhs-24thiaz-bala-betafph
6106:tolhs-oxadiaz-gly-betaph
6107:phhs-ithiadiaz-gly-aspaba
6108:phhs-25oxaz-bala-ibsdap
6109.ibhs-25thiaz-gly-betabpy
6110:bhs-25methiaz-bala-betabnaphth
6111;tolhs-25oxaz-bala-betambiph
6112:tolhs-me25thioph-gly-beta34meoph
106113:tolhs-25oxaz-bala-betathiome
6114:dhim-25thioph-gly-betainyl
6115:ibhs-25oxaz-bala-aspibua
6116:phhs-oxadiaz-gly-suabu
6117:ibhs-nme35pyr-bala-beta35dbph
156118:2py-25methiaz-leu-psdap
6119:bim-thiadiaz-gly-psdap
6120:ibhs-ithiadiaz-gly-betadcphch
6121:tolhs-oxadiaz-bala-betaibph
6122:bhs-ithiadiaz-bala-betafph
206123:ibhs-oxadiaz-bala-betahdbph
6124:bhs-25thiaz-bala-betafph
6125:phhs-nme35pyr-gly-betapym
6126:ibhs-25oxaz-bala-betadcph
6127:phhs-25oxaz-bala-betahdbph
256128:tolhs-oxadiaz-bala-betadmoph
6129:tolhs-24thioph-gly-betahdcph
6130:bhs-25methiaz-bala-betaph
6131:bhs-25thiaz-gly-betapyee
6132:tolhs-25methiaz-bala-betaimid
306133:gua-42pym-gly-betathio3
6134:bhs-25methiaz-nmgly-beta23meoph
6135:sabhs-42nmeim-gly-betapy
6136:bhs-24thiaz-bala-betathioph
6137:impy-25methiaz-bala-betaphethioa
356138:bhs-nme35pyr-gly-suabu
6139:tolhs-ithiadiaz-gly-betapy
6140:phhs-oxadiaz-gly-zdaptb

CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-192-
6141: phhs-ithiadiaz-gly-betahcbph
6142: tolhs-me24oxaz-ala-psdap
6143: bhs-oxadiaz-gly-betahmph
6144: ibhs-ithiadiaz-bala-betamesu
6145: bim-52thiaz-ala-zdap
6146: bhs-24thioph-ala-beta34dcph
6147: ibhs-24thiaz-bala-ibsdap
6148: tolhs-ithiadiaz-bala-betabnaphth
6149: ibhs-oxadiaz-gly-betadcphtb
106150: tolhs-oxadiaz-bala-betafphe
6151: tolhs-nme35pyr-gly-betapytb
6152: bhs-53pyrazo-ala-betadcph
6153: 2py-26py-nmala-zdap
6154: bhs-25oxaz-gly-betaheph
156155: bhs-25thiaz-gly-betapym
6156: bhs-24thiaz-leu-betapy
6157: phhs-oxadiaz-bala-betadhbfu
6158: phhs-oxadiaz-bala-asppha
6159: bhs-25thioph-gly-betainyl
206160: tolhs-oxadiaz-gly-zdap
6161: irnpy-25thiaz-ala-betapy
6162: tolhs-25methiaz-gly-busu2be
6163: 2py-35thioph-leu-psdap
6164: phhs-25methiaz-bala-betabpy
256165: 2py-26py-gly-betabnaphth
6166: bhs-25methiaz-bala-betahbcph
6167: ibhs-24thioph-gly-betaipr
6168: bhs-oxadiaz-bala-betaimid
6169: impy-25oxaz-bala-betabdimo
306170: gua-24thiaz-gly-betapbiph
6171: tolhs-24thioph-gly-beta13bendi
6172: bhs-24thioph-bala-betabph
6173: bhs-24thiaz-bala-betaimid
6174: ibhs-24thioph-gly-betadhbfu
356175: tolhs-24thiaz-gly-betabediox
6176: phhs-25oxaz-gly-betatrif
6177: bhs-triaz-gly-zdap

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-193
6178:bhs-25thiaz-gly-beta4bph
6179:tolhs-25thiaz-bala-betabenfu
6180:bhs-24thiaz-gly-betaheph
6181:bhs-nme35pyr-leu-zdap
6182:impy-42nmeim-bala-betabpy
6183:bhs-25methiaz-bala-aspibua
6184:tolhs-25thiaz-gly-betainyl
6185:toihs-me24thioph-leu-betaph
6186:2py-ithiad iaz-g ly-zdap
6187:impy-25oxaz-gly-betafu2
6188:tolhs-me25oxaz-gly-beta34meoph
6189:thpy-24thiaz-gly-betadcph
6190:2py-25oxaz-gly-aspaba
6191:tolhs-24thiaz-bala-zdap
6192:thpym-2thioph-gly-zdap
6193:phhs-25thiaz-bala-betahcbph
6194:ibhs-25methiaz-gly-betapyr
6195:bhs-ithiadiaz-bala-betaimid
6196:2py-me25thiaz-bala-betadcph
6197:bhs-25thiaz-gly-betafbph
6198:phhs-24thiaz-gly-betahcbph
6199:phhs-25thiaz-gly-betabmph
6200:bhs-25oxaz-gly-betabenfu
6201:bhs-ithiadiaz-bala-betaanaphth
6202:bim-me24thioph-gly-betapy
6203:bhs-24thioph-ala-beta3quin
6204:tolhs-25oxaz-bala-betahdbph
6205:bhs-oxadiaz-gly-psdap
6206:bhs-25oxaz-bala-betatos
6207:ibhs-oxadiaz-bala-betapyr
6208:tolhs-me24thiaz-bala-beta34meoph
6209:2pmhs-25methiaz-gly-betameph
6210:phhs-25oxaz-gly-betah35dc
6211:hyd-42pym-gly-psdap
6212:ibhs-ithiadiaz-gly-betaet
6213:2py-me24thioph-gly-betapy
6214:phhs-24thiaz-gly-betahbcph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-194
6215: phhs-oxadiaz-bala-zdap
6216: phhs-ithiadiaz-bala-betapyr
6217: phhs-24thioph-gly-asppha
6218: bhs-24thioph-bala-betaanaphth
6219: bhs-24thiaz-bala-betahbcph
6220: 2py-25methiaz-bala-zdap
6221: bhs-ithiadiaz-gly-betadbph
6222: 2pmhs-25methiaz-gly-betahbcph
6223: bhs-ithiadiaz-gly-betabpy
106224: bim-25thiaz-bala-betafphe
6225: phhs-24thiaz-bala-betahbcph
6226: ibhs-24thiaz-bala-betaimid
6227: bhs-25thiaz-bala-betadtrif
6228: bhs-35fur-ala-zdap
156229: bhs-ithiadiaz-bala-aspaba
6230: bhs-24thiaz-bala-betapytb
6231: tolhs-25oxaz-bala-beta23meoph
6232: bim-24thioph-bala-betafphe
6233: ibhs-24thioph-bala-betadcphtb
206234: bim-triaz-leu-zdap
6235: tolhs-25methiaz-bala-aspaba
6236: bhs-25oxaz-gly-zdapee
6237: bhs-nme35pyr-bala-betadhbfu
6238: ibhs-25oxaz-gly-betainyl
256239: phhs-me24thiaz-leu-betapy
6240: phhs-nme35pyr-bala-betatrif
6241: bhs-nme35pyr-gly-betapych
6242: bim-nme35pyr-gly-psdap
6243: phhs-ithiadiaz-gly-zdapch
306244: bhs-42oxaz-gly-psdap
6245: bhs-me24thiaz-ala-psdap
6246: tolhs-25methiaz-bala-betaet
6247: bhs-me24oxaz-bala-betadcph
6248: phhs-25methiaz-bala-betaoxope
356249: bhs-oxadiaz-gly-betabthioph
6250: tolhs-25methiaz-gly-betahdbph
6251: phhs-oxadiaz-gly-betabph

CA 02371604 2001-10-24
WOOO166618 PCTlEP00103469
-195-
6252:ibhs-ithiadiaz-gly-betaphethioa
6253:tolhs-25oxaz-bala-beta35dbph
6254:tolhs-24thiaz-gly-betadbph
6255:ibhs-25oxaz-gly-betafbph
6256:impy-25thiaz-bala-betainyl
6257:2py-24thioph-gly-zdap
6258:phhs-oxadiaz-gly-psdaptb
6259:dhthi-25thiaz-bala-betadcph
6260:ibhs-24thiaz-gly-betafu3
106261:phhs-me24oxaz-ala-betadcph
6262:bhs-ithiadiaz-bala-betadtrif
6263:bhs-ithiadiaz-nmgly-beta34meoph
6264:bhs-24thiaz-gly-betapytb
6265:2py-24thioph-ala-psdap
156266:nmhs-26py-gly-betapy
6267:bim-26py-ala-psdap
6268:gua-26py-gly-betamesu
6269:2py-oxadiaz-bala-aspbzla
6270:phhs-24thioph-bala-betadcphch
206271:gua-42pym-gly-betacbph
6272:bhs-24thiaz-bala-betabpy
6273:phhs-ithiadiaz-bala-betainyl
6274:phhs-ithiadiaz-gly-betadcphch
6275:phhs-25thiaz-bala-betahph
256276:ibhs-25methiaz-bala-betapyee
6277:ibhs-24thiaz-gly-aspbzla
6278:phhs-24thiaz-bala-betaoxope
6279:ibhs-24thioph-bala-betaphethioa
6280:tolhs-ithiadiaz-gly-betamethi
306281:bim-24thiaz-gly-betainyl
6282:phhs-25oxaz-bala-betapym
6283:tolhs-me24oxaz-bala-zdap
6284:bhs-25thioph-bala-betapy
6285:tolhs-24thioph-bala-betaimid
356286:bim-25thiaz-gly-aspbzla
6287:tolhs-ithiadiaz-gly-betadtrif
6288:ibhs-24thiaz-bala-betaftrif

CA 02371604 2001-10-24
W000166618 PCTIEP00/03469
-196-
6289:2py-thiadiaz-bala-psdap
6290:phhs-25oxaz-bala-betabmph
6291:phhs-nme35pyr-gly-betahmph
6292:2py-53pyrazo-gly-betadcph
6293:bhs-me24thiaz-leu-psdap
6294:bim-24im-gly-betadcph
6295:2py-24oxaz-ala-betameph
6296:tolhs-24thiaz-gly-betahbcph
6297:phhs-25methiaz-bala-beta35dbph
6298:phhs-25thiaz-gly-betapyr
6299:ibhs-25thiaz-bala-betadbph
6300:bhs-nme35pyr-bala-betaet
6301:bim-me25thiaz-gly-zdap
6302:phhs-25thiaz-bala-betaanaphth
6303:bhs-nme35pyr-gly-betaol
6304:phhs-24thioph-bala-betadtrif
6305:phhs-me25thiaz-leu-beta34meoph
6306:ibhs-25thiaz-gly-betamethi
6307:bim-24thioph-leu-zdap
6308:bhs-ithiadiaz-bala-betathio3
6309:2pmhs-24thiaz-gly-betabpy
6310:bhs-24thiaz-gly-betapym
6311:phhs-25methiaz-gly-betampy
6312:bim-25oxaz-bala-asppha
6313:impy-42nmeim-gly-betamethioph
6314:tolhs-nme35pyr-bala-betahcbph
6315:bhs-oxadiaz-bala-betabnaphth
6316:bhs-nme35pyr-gly-betaipr
6317:ibhs-24thiaz-bala-betahc
6318:tolhs-25methiaz-gly-betaanaphth
6319:2py-me25thioph-bala-betaph
6320:tolhs-24thioph-gly-betapych
6321:ibhs-oxadiaz-gly-betabenfu
6322:phhs-25thiaz-gly-betamesu
6323:tolhs-me24thioph-bala-betaph
6324:dimethpym-26py-gly-betahdcph
6325:ibhs-25thiaz-gly-beta34meoph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-197-
6326: bim-me25thiaz-gly-betapy
6327: phhs-24thioph-gly-betapym
6328: 2py-me25thiaz-ala-beta34meoph
6329: phhs-oxadiaz-bala-betadbph
6330: ibhs-nme35pyr-bala-betafbph
6331: ibhs-25thiaz-bala-betatrif
6332: tolhs-oxadiaz-gly-betaipr
6333: bim-me25thiaz-bala-betapy
6334: bhs-25oxaz-gly-betahc
106335: ibhs-24thioph-bala-betadtrif
6336: bhs-nme35pyr-gly-betahmo
6337: 2py-52thiaz-gly-betadcph
6338: bhs-35fur-leu-betadcph
6339: dhim-26py-gly-betainyl
156340: bim-me24thiaz-ala-zdap
6341: ibhs-nme35pyr-gly-betamesu
6342: ibhs-oxadiaz-bala-aspibua
6343: tolhs-24thiaz-bala-psdapee
6344: bim-me24oxaz-bala-psdap
206345: bhs-me24thioph-gly-psdap
6346: bhs-24thioph-gly-betaet
6347: ibhs-ithiadiaz-bala-beta23meoph
6348: 2py-25thiaz-bala-suabu
6349: bhs-me24thiaz-bala-betadcph
256350: 2py-25thiaz-bala-betaet
6351: bhs-oxadiaz-gly-asppha
6352: ibhs-24thioph-bala-beta13bendi
6353: phhs-25methiaz-bala-betabnaphth
6354: 2py-25thiaz-gly-betacthioph
306355; dhim-25oxaz-bala-betadcph
6356: phhs-me24thioph-bala-psdap
6357: 2py-ithiadiaz-bala-aspibua
6358: phhs-24thioph-gly-betadmoph
6359: bhs-ithiadiaz-bala-betadcphch
356360: ibhs-24thiaz-bala-betadmoph
6361: phhs-24thioph-bala-beta4bph
6362: ibhs-25oxaz-bala-betapych

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-198-
6363: ibhs-24thioph-bala-betabph
6364: bhs-25oxaz-ala-betapy
6365: bim-25fur-leu-betapy
6366: ibhs-24thioph-bala-beta35dbph
6367: bhs-24thioph-bala-betaftrif
6368: bhs-25fur-ala-zdap
6369: bhs-25thiaz-baia-beta34meoph
6370: thazep-26py-gly-betapy
6371: bhs-nme35pyr-gly-betathio3
6372:2pmhs-25oxaz-bala-betaoxope
6373: tolhs-oxadiaz-gly-betacph
6374: phhs-25methiaz-bala-psdaptb
6375: bim-25thiaz-nmala-betadcph
6376: bim-25thiaz-bala-aspbzla
6377:bhs-24thiaz-nmgly-betafphe
6378: tolhs-ithiadiaz-gly-betaph
6379: ibhs-ithiadiaz-bala-betaol
6380: impy-24thioph-gly-betathiobe
6381: tolhs-25methiaz=gly-betacthioph
6382:ibhs-24thiaz-bala-betameph
6383: 2py-25methiaz-bala-betaet
6384: bhs-25oxaz-nmgly-beta34meoph
6385: gua-24thiaz-gly-betapy
6386: tolhs-25oxaz-bala-betahcbph
6387:bhs-42nmeim-bala-betacthioph
6388; tolhs-25methiaz-gly-betameph
6389: ibhs-25thiaz-bala-betathiome
6390: bhs-nme35pyr-bala-betathio3
6391: phhs-oxadiaz-bala-betahmofu
6392:ibhs-ithiadiaz-bala-betadmoph
6393: tolhs-24thiaz-gly-aspaba
6394: impy-25thiaz-bala-betamesu
6395: ibhs-24thiaz-gly-betaibph
6396; bhs-25oxaz-bala-betainyl
6397:bhs-25methiaz-bala-betahph
6398: gua-25thiaz-nmgly-betapy
6399: bhs-24thioph-gly-aspbzla

CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-199
6400: bhs-25oxaz-nmgly-ibsdap
6401: 2py-24im-leu-zdap
6402: phhs-nme35pyr-bala-betafbph
6403: tolhs-25oxaz-bala-zdap
6404: phhs-oxadiaz-gly-betahmofu
6405: bim-42nmeim-bala-betathiobe
6406: bhs-25oxaz-bala-zdaptb
6407: ibhs-25thiaz-gly-aspbzla
6408: bim-24oxaz-bala-betapy
106409: ibhs-25oxaz-gly-beta13bendi
6410: bhs-24thiaz-gly-betahbcph
6411: ibhs-25methiaz-bala-betapbiph
6412: tolhs-ithiadiaz-bala-betadito
6413: phhs-ithiadiaz-bala-betatrif
156414: tolhs-24thiaz-gly-betadcphch
6415: bim-25methiaz-bala-betacph
6416: phhs-25methiaz-gly-betamethioph
6417: tolhs-25methiaz-gly-betapyr
6418: bhs-ithiadiaz-gly-psdaptb
206419: ibhs-ithiadiaz-bala-betapyr
6420: phhs-24thioph-bala-betahdbph
6421: dlhim-42pym-ala-betapy
6422: bhs-25thiaz-ala-betambiph
6423: 2py-24thioph-gly-asppha
256424: phhs-24thiaz-bala-betafph
6425: 2py-24thiaz-bala-betaet
6426: tolhs-ithiadiaz-bala-betahph
6427: 2py-nme35pyr-ala-betadcph
6428: phhs-me24thioph-bala-betaph
306429: bhs-25oxaz-gly-betaoxope
6430: phhs-24thiaz-gly-betaimid
6431: tolhs-25methiaz-gly-betafphe
6432: bhs-35thioph-leu-betapy
6433: ibhs-25thiaz-bala-betadcphch
356434: toihs-25thiaz-bala-betatbuph
6435: bhs-24im-gly-betadcph
6436: 2py-26py-gly-betameph

CA 02371604 2001-10-24
W000166618 PCTIEPOOl03469
-200
6437: hs-25thioph-gly-zdap
6438: phhs-me24oxaz-gly-zdap
6439. tolhs-25oxaz-bala-betadhbfu
6440: bhs-24thioph-bala-betabdimo
6441: ibhs-ithiadiaz-bala-betahdbph
6442: phhs-24thioph-bala-betapym
6443: phhs-25methiaz-g1y-betadcphee
6444: bhs-25methiaz-gly-betahph
6445: phhs-24thiaz-bala-betaheph
6446: bhs-25oxaz-gly-betaoxaz
6447: bhs-24thiaz-bala-aspibua
6448: phhs-ithiadiaz-gly-betabthioph
6449: agua-26py-gly-betainyl
6450: phhs-24thioph-gly-betahmofu
6451: bhs-oxadiaz-bala-betatrif
6452: bhs-me24thioph-ala-betaph
6453: tolhs-25methiaz-gly-betabediox
6454: tolhs-24thioph-bala-betabediox
6455: bhs-24thioph-gly-betambiph
6456: bim-35fur-leu-betapy
6457: phhs-24thiaz-gly-csdap
6458: agua-42nmeim-gly-betapy
6459: tolhs-me24thioph-ala-psdap
6460: tolhs-ithiadiaz-bala-betabdimo
6461: tolhs-me25oxaz-gly-betaph
6462: 2py-oxadiaz-gly-asppha
6463: tolhs-25thiaz-gly-betahph
6464: bhs-nme35pyr-gly-betahdbph
6465: bhs-24thiaz-gly-ibsdap
6466: phhs-nme35pyr-gly-beta4bph
6467: bhs-25oxaz-bala-betathiome
6468: tolhs-25thiaz-bala-betaamibe
6469: tolhs-25oxaz-bala-zdapee
6470: impy-25thiaz-bala-betaftrif
6471: tolhs-25oxaz-gly-betadcphtb
6472: bhs-me24thioph-bala-psdap
6473: bhs-nme35pyr-nmgly-betathio3

CA 02371604 2001-10-24
W000/66618 PCTIEP00103469
-201
6474: bhs-oxadiaz-gly-betapym
6475: phhs-24thioph-gly-betadito
6476: ibhs-25oxaz-bala-betapbiph
6477: tolhs-nme35pyr-bala-betatrif
6478: bhs-25methiaz-bala-beta34dcph
6479: bim-25methiaz-gly-betadmph
6480: phhs-25methiaz-gly-betahc
6481: tolhs-24thiaz-bala-betah35dc
6482: bhs-me25thioph-ala-betaph
6483:tolhs-oxadiaz-gly-betahmph
6484: tolhs-25thiaz-bala-betatos
6485: tolhs-ithiadiaz-gly-betaol
6486: tolhs-24thioph-bala-betadmoph
6487: tolhs-oxadiaz-gly-betainyl
6488:phhs-25methiaz-bala-beta4bph
6489: bim-thiadiaz-ala-betadcph
6490: ur-25methiaz-gly-betadcph
6491: bim-42nmeim-nmgly-zdap
6492: tolhs-24thiaz-bala-betaph
6493:ibhs-24thioph-gly-betapyee
6494: thazep-24oxaz-gly-betainyl
6495: 4pmhs-25thiaz-bala-betameph
6496: ibhs-25methiaz-gly-suabu
6497: tolhs-25thiaz-bala-betapym
6498:bhs-oxadiaz-gly-beta23meoph
6499: tolhs-nme35pyr-gly-psdap
6500: 2pmhs-42nmeim-gly-betahmo
6501: phhs-ithiadiaz-bala-betaomebendi
6502: bhs-me24thiaz-ala-beta34meoph
6503:bhs-24thiaz-bala-beta3quin
6504: phhs-25methiaz-gly-betathioph
6505: tolhs-me25oxaz-gly-betapy
6506: phhs-24thioph-gly-betapyr
6507: tolhs-25oxaz-bala-betapym
6508:bhs-ithiadiaz-gly-betaph
6509: bim-25oxaz-leu-psdap
6510: impy-24thioph-bala-betaftrif

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-202
6511: phhs-24thioph-gly-betah35dc
6512; ibhs-24thiaz-gly-betadmoph
6513: bhs-42oxaz-ala-betapy
6514: thazep-42nmeim-bala-betameph
6515: bhs-24thiaz-bala-busu2be
6516: gua-25thiaz-gly-betahph
6517: gua-24thiaz-gly-betainyl
6518: bhs-25thiaz-gly-betahmofu
6519: phhs-nme35pyr-gly-betahmo
6520:bhs-25thiaz-gly-betaamibe
6521: phhs-24thioph-gly-betapy
6522: bhs-oxadiaz-gly-betadmph
6523: tolhs-me24oxaz-ala-betadcph
6524: thazep-25methiaz-bala-zdap
6525:tolhs-ithiadiaz-bala-aspibua
6526: phhs-me25oxaz-bala-zdap
6527: phhs-nme35pyr-gly-betadito
6528: 2py-24oxaz-bala-psdap
6529: bhs-25methiaz-bala-beta35dbph
6530:phhs-24thioph-bala-zdaptb
6531: bhs-35fur-gly-betadcph
6532: phhs-25thiaz-gly-beta34meoph
6533: phhs-25thiaz-gly-betaphethio
6534: agua-24oxaz-gly-betainyl
6535:phhs-25oxaz-bala-betahc
6536: 2py-53pyrazo-leu-zdap
6537: ibhs-25methiaz-bala-aspibua
6538: 2py-24thiaz-gly-betapy
6539: tolhs-ithiadiaz-gly-betaphethio
6540:ibhs-oxadiaz-bala-betaipr
6541: bhs-25thiaz-gly-betathio3
6542: gua-24oxaz-gly-betacbph
6543: bhs-24oxaz-gly-betapy
6544: tolhs-24thioph-bala-betafu2
6545:phhs-24thioph-gly-betamethi
6546: bhs-nme35pyr-bala-beta34dcph
6547: phhs-oxadiaz-bala-betaheph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-203
6548:2py-oxadiaz-gly-betapy
6549:bhs-25methiaz-nmgly-betameph
6550:2py-me24oxaz-ala-betadcph
6551:bim-triaz-ala-psdap
6552:ibhs-25thiaz-gly-betabenfu
6553:bim-42nmeim-bala-betapy
6554:bhs-25thiaz-gly-betabnaphth
6555:bhs-ithiadiaz-bala-betadhbfu
6556:tolhs-25thiaz-gly-betaipro
6557:dhpyrr-26py-gly-psdap
6558:bhs-24thiaz-ala-betadcph
6559:hs-25thiaz-gly-betainyl
6560:bhs-25oxaz-gly-betamethi
6561:bhs-nme35pyr-bala-beta34meoph
6562:ibhs-25methiaz-bala-betaomebendi
6563:phhs-24thioph-gly-betadcphtb
6564:ibhs-25thiaz-gly-betatbuph
6565:ibhs-oxadiaz-gly-betafluo
6566:2pmhs-24thiaz-phe-zdap
6567:ibhs-24thioph-gly-betabph
6568:2py-42nmeim-gly-betaimid
6569:ibhs-25methiaz-gly-betahni
6570:phhs-25methiaz-bala-psdapch
6571:phhs-25oxaz-gly-betabpy
6572:bhs-24thiaz-nmgly-beta13bendi
6573:ibhs-oxadiaz-gly-betabediox
6574:ibhs-nme35pyr-gly-betacph
6575:bim-24im-leu-psdap
6576:bim-25thiaz-gly-betaomebendi
6577:tolhs-oxadiaz-gly-zdapee
6578:ibhs-24thioph-gly-betahcbph
6579:ibhs-25methiaz-bala-betainyl
6580:ibhs-ithiadiaz-bala-zdapee
6581:tolhs-ithiadiaz-bala-betahc
6582:tolhs-24thioph-gly-betamesu
6583:tolhs-24thiaz-bala-suabu
6584:bhs-24im-ala-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-204
6585:gua-24thiaz-gly-beta4bph
6586:bhs-25thiaz-bala-betaipr
6587:ibhs-25oxaz-gly-betabnaphth
6588:ibhs-nme35pyr-gly-betadito
6589:bim-me25thiaz-ala-zdap
6590:bhs-24thioph-bala-zdapee
6591:ibhs-oxadiaz-giy-betafu2
6592:2py-me25thiaz-leu-betapy
6593:phhs-24thiaz-bala-betaipr
6594:tolhs-ithiadiaz-bala-betafluo
6595:ibhs-24thioph-bala-betaamibe
6596:2py-25thioph-gly-betapy
6597:bhs-25oxaz-leu-betapy
6598:tolhs-ithiadiaz-gly-betaamibe
6599:bhs-me24oxaz-leu-betadcph
6600:bhs-nme35pyr-bala-betafluo
6601:bhs-24thiaz-ala-betabpy
6602:ibhs-25methiaz-bala-betaipr
6603:bhs-24thiaz-bala-betadhbfu
6604:tolhs-25thiaz-gly-beta13bendi
6605:phhs-nme35pyr-gly-betadcphee
6606:bhs-25oxaz-gly-betabmph
6607:phhs-25methiaz-gly-betaipr
6608:tolhs-25oxaz-gly-betaftrif
6609:bhs-25oxaz-bala-betaphethioa
6610:ibhs-24thioph-gly-betaheph
6611:bhs-24thioph-gly-suabu
6612:tolhs-25methiaz-bala-betamethioph
6613:tolhs-24thioph-gly-asppha
6614:ibhs-25methiaz-bala-betaol
6615:phhs-24thiaz-bala-betapytb
6616:2pmhs-42nmeim-bala-betafu2
6617:tolhs-oxadiaz-gly-aspibua
6618:bhs-oxadiaz-nmgly-ibsdap
6619:tolhs-24thioph-gly-betapym
6620:ibhs-nme35pyr-bala-betahmofu
6621:bhs-35thioph-bala-zdap

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-205-
6622: 2pmhs-25methiaz-gly-betahb
6623: gua-26py-gly-betah35dc
6624: phhs-24thiaz-gly-betapytb
6625: bim-42nmeim-gly-betaphethioa
6626: 2py-triaz-gly-zdap
6627: bhs-24thiaz-gly-zdap
6628: bhs-24thiaz-bala-betampy
6629: bim-25oxaz-gly-asppha
6630: tolhs-ithiadiaz-bala-beta35dbph
106631: phhs-nme35pyr-bala-asppha
6632: ibhs-oxadiaz-gly-betadhbfu
6633: ibhs-ithiadiaz-bala-betadcphch
6634: 2py-ithiadiaz-gly-aspaba
6635: bhs-25oxaz-nmgly-beta3quin
156636: ibhs-25oxaz-bala-zdapee
6637: bhs-25oxaz-gly-betabthioph
6638: bhs-oxadiaz-gly-betabph
6639: phhs-oxadiaz-bala-betameph
6640: tolhs-me25thioph-bala-betapy
206641: tolhs-ithiadiaz-gly-betahdbph
6642: bim-24thiaz-gly-betadcph
6643: ibhs-nme35pyr-gly-betaphethioa
6644: tolhs-25thiaz-gly-betathio3
6645: phhs-24thioph-bala-betapych
256646: 2py-35fur-leu-betapy
6647: bhs-24chin-gly-zdap
6648: tolhs-oxadiaz-gly-betaamibe
6649: bhs-24thioph-nmgly-betahph
6650: ibhs-oxadiaz-gly-betabdimo
306651: 2py-me24oxaz-gly-beta34meoph
6652: bhs-25thiaz-gly-betaimid
6653: bim-24thiaz-ala-betadcph
6654: tolhs-25oxaz-gly-zdap
6655: bhs-ithiadiaz-gly-betacbph
356656: tolhs-nme35pyr-gly-beta13bendi
6657: 2py-thiadiaz-bala-betapy
6658: dhim-24oxaz-gly-psdap

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-206
6659: bhs-nme35pyr-bala-psdap
6660: tolhs-oxadiaz-bala-psdapee
6661: gua-25thiaz-gly-betadmoph
6662: bhs-me24thioph-ala-betadcph
6663: bhs-25methiaz-gly-betapbiph
6664: bhs-25oxaz-bala-betadcphch
6665: ibhs-ithiadiaz-bala-betadmph
6666: bim-23thioph-gly-zdap
6667: phhs-24thiaz-bala-betahb
6668: tolhs-25methiaz-gly-betapy
6669: bhs-24thioph-met-betadcph
6670: tolhs-24thioph-bala-betapych
6671: 2py-25thioph-leu-betapy
6672: ibhs-25oxaz-bala-asppha
6673: phhs-me24oxaz-bala-zdap
6674: ibhs-25oxaz-bala-betabnaphth
6675: tolhs-24thioph-gly-betapbiph
6676: bhs-ithiadiaz-leu-betapy
6677: bhs-25oxaz-bala-zdap
6678: phhs-25methiaz-gly-betahcbph
6679: tolhs-24thiaz-bala-betahmph
6680: tolhs-nme35pyr-gly-betabpy
6681: ibhs-25methiaz-gly-betaphethio
6682: tolhs-oxadiaz-bala-betahc
6683: phhs-25oxaz-bala-zdaptb
6684: ibhs-nme35pyr-bala-betabnaphth
6685: ibhs-25methiaz-gly-aspbzla
6686. tolhs-24thiaz-bala-betafluo
6687: bhs-ithiadiaz-nmgly-betacph
6688: tolhs-25oxaz-bala-betaipro
6689: bim-25thioph-leu-betapy
6690: ibhs-oxadiaz-bala-betathiobe
6691: gua-24thiaz-gly-betathiome
6692: bhs-25thioph-ala-betadcph
6693: 2py-24oxaz-ala-betapy
6694: phhs-25methiaz-bala-betahcbph
6695: ibhs-25thiaz-bala-betathioph

CA 02371604 2001-10-24
W000166618 PCTlEP0010346g
-207
6696:ibhs-25oxaz-bala-betapytb
6697:phhs-25thiaz-gly-suabu
6698:phhs-me25thioph-bala-zdap
6699:phhs-oxadiaz-gly-betahmo
6700:bhs-25thiaz-gly-betabpy
6701:phhs-24thiaz-bala-betainyl
6702:phhs-24thiaz-bala-betaph
6703:bhs-25methiaz-nmgly-betainyl
6704:bhs-nme35pyr-gly-betabpy
6705:bhs-25methiaz-bala-betadtrif
6706:phhs-24thiaz-bala-betafluo
6707:2py-25thiaz-bala-zdap
6708;2py-25oxaz-bala-asppha
6709:tolhs-25methiaz-bala-betafu2
6710:bhs-25thiaz-bala-beta34dcph
6711:2py-25oxaz-ala-betadcph
6712:bhs-25methiaz-bala-zdap
6713:phhs-oxadiaz-gly-betamethi
6714:phhs-ithiadiaz-bala-betamesu
6715:bhs-24thiaz-bala-betamethioph
6716:bhs-25oxaz-gly-betapym
6717:bhs-ithiadiaz-ala-betainyl
6718:phhs-24thioph-gly-betabmph
6719:ibhs-25methiaz-gly-betadmph
6720;ibhs-24thiaz-bala-betahmo
6721:tolhs-24thiaz-gly-beta34dcph
6722:phhs-25methiaz-gly-betaphethioa
6723:2py-me25oxaz-leu-betaph
6724:phhs-ithiadiaz-bala-betathioph
6725:bhs-me25thiaz-leu-betadcph
6726:bhs-25oxaz-bala-betaol
6727:bhs-24thiaz-nmgly-betaanaphth
6728:ibhs-24thioph-bala-betamethioph
6729:phhs-25methiaz-bala-betamethi
6730:ibhs-nme35pyr-gly-zdapee
6731:bhs-24thioph-bala-beta13bendi
6732:ibhs-25oxaz-bala-psdapch

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-208-
6733: ibhs-ithiadiaz-gly-betaoxope
6734: tolhs-25thiaz-gly-betaol
6735: tolhs-nme35pyr-gly-betadtrif
6736: bhs-26py-ala-betadcph
6737: tolhs-25thiaz-gly-betadcphtb
6738: impy-25methiaz-gly-betabediox
6739: bhs-25thioph-ala-betapy
6740: phhs-25thiaz-gly-betadito
6741: phhs-oxadiaz-gly-beta34dcph
6742: bim-25oxaz-gly-betabpy
6743: ibhs-25methiaz-bala-betadcph
6744: tolhs-25methiaz-bala-ibsdap
6745: phhs-oxadiaz-gly-betaftrif
6746: tolhs-oxadiaz-gly-betaoxaz
6747: 2py-thiadiaz-leu-zdap
6748: tolhs-me24thioph-leu-zdap
6749: ibhs-oxadiaz-bala-betaoxope
6750: bhs-ithiadiaz-gly-betaanaphth
6751: thazep-24thiaz-gly-betainyl
6752: tolhs-ithiadiaz-gly-betaipr
6753: bhs-35thioph-ala-psdap
6754: bhs-24thioph-bala-betapytb
6755: bhs-me25thiaz-ala-betapy
6756: bhs-25oxaz-gly-betaipro
6757: ibhs-25methiaz-bala-betahbcph
6758: bim-52thiaz-gly-betainyl
6759: ibhs-24thioph-bala-betafph
6760: 2py-25thioph-leu-zdap
6761: ibhs-25oxaz-bala-betaet
6762: bhs-me25thiaz-leu-betapy
6763: ibhs-25oxaz-gly-betabediox
6764: ibhs-nme35pyr-bala-betabpy
6765: phhs-24thioph-bala-betafph
6766: tolhs-25methiaz-gly-betah35dc
6767: tolhs-25oxaz-bala-aspibua
6768: 2py-oxadiaz-gly-zdap
6769: bhs-ithiadiaz-leu-psdap

CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-209-
6770:2 py-24oxaz-g ly-psd
a p
6771:bhs-46pym-gly-betameph
6772:tolhs-ithiadiaz-bala-zdapch
6773:ibhs-25oxaz-gly-betathiome
6774:bhs-25oxaz-nmgly-betadmoph
6775:tolhs-25oxaz-bala-betahbcph
6776:ibhs-25oxaz-bala-betaphethio
6777:phhs-nme35pyr-bala-betadhbfu
6778:bhs-me24thioph-ala-zdap
6779:bhs-triaz-leu-psdap
6780:ibhs-24thioph-bala-aspibua
6781:bhs-24py-gly-betapy
6782:gua-25thiaz-gly-beta4bph
6783:ibhs-oxadiaz-bala-betabdimo
6784:gua-24thiaz-gly-betambiph
6785:bhs-nme35pyr-ala-beta23meoph
6786:bhs-24thioph-bala-betatbuph
6787:bhs-nme35pyr-bala-zdap
6788:ibhs-24thioph-bala-betafphe
6789:phhs-24thiaz-bala-aspbzla
6790;ibhs-ithiadiaz-gly-aspbzla
6791:bhs-24thiaz-bala-betaol
6792:bhs-25methiaz-gly-betadtrif
6793:ibhs-25methiaz-bala-betaanaphth
6794:tolhs-25oxaz-gly-betamethi
6795:phhs-oxadiaz-bala-betahb
6796:2py-me25thiaz-bala-zdap
6797:bhs-24thiaz-gly-betainyl
6798:impy-25thiaz-bala-busu2be
6799:bhs-24thioph-gly-betadbph
6800:ibhs-oxadiaz-gly-aspibua
6801:2py-25fur-leu-zdap
6802:ibhs-25thiaz-gly-betafbph
6803:tolhs-ithiadiaz-bala-betabediox
6804:impy-24thioph-bala-betafu3
6805:phhs-25methiaz-gly-beta35dbph
6806:tolhs-me24thioph-bala-beta34meoph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-210-
6807: bhs-oxadiaz-bala-betafphe
6808: tolhs-oxadiaz-bala-betafu2
6809: cima-25thiaz-gly-betainyl
6810: bhs-25oxaz-bala-betahph
6811:ibhs-25oxaz-bala-betatos
6812: ibhs-25thiaz-bala-betacbph
6813: gua-42pym-gly-betaol
6814: tolhs-ithiadiaz-bala-psdap
6815: 2py-26py-gly-betainyl
6816:bhs-24thioph-gly-betadhbfu
6817: tolhs-ithiadiaz-bala-betabph
6818: tolhs-24thioph-bala-betaheph
6819: phhs-25thiaz-gly-betabnaphth
6820: tolhs-25thiaz-bala-betathiobe
6821:bhs-oxadiaz-ala-beta34dcph
6822: phhs-me24oxaz-leu-betaph
6823: bhs-24thiaz-nmgly-betadito
6824: phhs-oxadiaz-gly-betahni
6825: 2py-25oxaz-bala-betamesu
6826:ibhs-nme35pyr-bala-betathiobe
6827: bhs-24thioph-gly-betaheph
6828: phhs-24thiaz-gly-zdapee
6829: ibhs-nme35pyr-gly-betadcphch
6830: tolhs-24thiaz-gly-betatos
6831:tolhs-ithiadiaz-bala-betahmo
6832: bhs-me24thiaz-gly-betameph
6833: dhim-me25thiaz-ala-betameph
6834: ibhs-24thiaz-bala-betampy
6835: ibhs-25oxaz-bala-psdaptb
6836:tolhs-25thiaz-bala-betampy
6837: ibhs-nme35pyr-g!y-betampy
6838: tolhs-me25thiaz-gly-zdap
6839: tolhs-25thiaz-bala-betaftrif
6840: ibhs-24thiaz-gly-betafbph
6841:bhs-oxadiaz-ala-betadmph
6842: tolhs-oxadiaz-bala-betadito
6843: tolhs-25thiaz-bala-betamesu

CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-211
6844:tolhs-25oxaz-gly-betadcphee
6845:gua-25thiaz-gly-beta35dbph
6846:tolhs-nme35pyr-gly-betaphethio
6847:gua-24oxaz-gly-beta34dcph
6848:2py-24thiaz-ala-zdap
6849:tolhs-oxadiaz-gly-betafphe
6850:tolhs-25oxaz-gly-beta23meoph
6851:ibhs-24thiaz-bala-beta23meoph
6852:phhs-nme35pyr-gly-betahc
6853:gua-24oxaz-gly-betadmph
6854:bhs-25fur-gly-psdap
6855:bhs-24thiaz-gly-betadbph
6856:ibhs-25thiaz-gly-betabph
6857:2py-triaz-ala-psdap
6858:tolhs-ithiadiaz-bala-csdap
6859:tolhs-ithiadiaz-gly-betadito
6860:tolhs-24thiaz-gly-betapyr
6861:bhs-ithiadiaz-gly-betafluo
6862:tolhs-24thioph-gly-betafu2
6863:ibhs-24thioph-gly-betathioph
6864:2py-53pyrazo-bala-betadcph
6865:tolhs-oxadiaz-bala-betabenfu
6866.tolhs-25thiaz-bala-betahmo
6867:ibhs-oxadiaz-gly-betahb
6868:bhs-25thiaz-ala-betameph
6869:phhs-ithiadiaz-gly-betathiome
6870:phhs-oxadiaz-g1y-betadbph
6871:tolhs-25oxaz-gly-betaoxope
6872:bhs-oxadiaz-bala-betadbph
6873:bhs-ithiadiaz-bala-betadcphee
6874:bhs-me24oxaz-gly-betadcph
6875:tolhs-25thiaz-gly-betaphethioa
6876:dhim-26py-ala-betameph
6877:tolhs-oxadiaz-gly-psdap
6878:tolhs-oxadiaz-bala-betahcbph
6879:bim-24thiaz-bala-aspbzla
6880:phhs-24thioph-gly-beta34dcph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-212
6881:bim-42oxaz-leu-zdap
6882:phhs-25oxaz-bala-betathiobe
6883:tolhs-24thiaz-bala-betathio3
6884:2py-35thioph-bala-zdap
6885:bim-25fur-bala-zdap
6886:bim-me25thioph-leu-psdap
6887:ibhs-25thiaz-gly-betafu2
6888:bhs-24thiaz-gly-betaamibe
6889:2pmhs-24thiaz-gly-betameph
6890:ibhs-24thioph-gly-psdapee
6891:phhs-25methiaz-gly-psdapch
6892:ibhs-24thiaz-gly-suabu
6893:bhs-25thiaz-ala-betapy
6894:dhim-52thiaz-ala-psdap
6895:tolhs-25thiaz-gly-zdaptb
6896:ibhs-24thiaz-gly-aspibua
6897:2pmhs-42nmeim-bala-beta23meoph
6898:2py-52thiaz-gly-betapy
6899:bhs-ithiadiaz-gly-betathiome
6900:bhs-ithiadiaz-bala-betabnaphth
6901:2py-24oxaz-leu-zdap
6902:tolhs-24thioph-bala-betaphethio
6903:bhs-35fur-gly-zdap
6904:hts-25thiaz-gly-betapy
6905:2py-oxadiaz-bala-aspibua
6906:tolhs-nme35pyr-gly-betabdcph
6907:ibhs-ithiadiaz-bala-psdaptb
6908:ibhs-25methiaz-bala-betacbph
6909:2py-25oxaz-bala-busu2be
6910:bim-me25thiaz-leu-betaph
6911:phhs-25thiaz-bala-betaphethioa
6912:ibhs-ithiadiaz-bala-betafluo
6913:gua-25thioph-gly-betadcph
6914:bhs-25thiaz-bala-betaomebendi
6915:phhs-25methiaz-bala-betaet
6916:2pmhs-42nmeim-bala-betahdbph
6917:bhs-35thioph-gly-zdap

CA 02371604 2001-10-24
WOOOI66618 PCTIEP00103469
-213
6918:ibhs-oxadiaz-bala-ibsdap
6919:tolhs-24thiaz-gly-betaanaphth
6920:2py-me24oxaz-leu-betadcph
6921:phhs-25methiaz-bala-psdapee
6922:pahs-42nmeim-bala-betadcph
6923:ibhs-oxadiaz-bala-betaol
6924:ibhs-25thiaz-gly-betapych
6925:bhs-42nmeim-leu-psdap
6926:tolhs-nme35pyr-gly-betadmoph
106927:phhs-24thioph-gly-ibsdap
6928:tolhs-me25thioph-gly-psdap
6929:phhs-25oxaz-gly-betaoxope
6930:bhs-oxadiaz-gly-aspaba
6931:tolhs-25thiaz-bala-betafluo
156932:tolhs-25methiaz-gly-betahb
6933:tolhs-ithiadiaz-gly-psdapee
6934:2py-42nmeim-gly-betahc
6935:tolhs-25thiaz-gly-betaphethio
6936:bhs-ithiadiaz-bala-betamethi
206937:tolhs-25methiaz-gly-betabph
6938:bhs-24thioph-gly-betaanaphth
6939:phhs-25methiaz-gly-beta34meoph
6940:tolhs-25methiaz-gly-betadmoph
6941:bhs-24thiaz-gly-betadmph
256942:2py-24thioph-gly-beta35dbph
6943:ibhs-25oxaz-gly-betabmph
6944:bhs-ithiadiaz-bala-beta34meoph
6945:bim-42oxaz-ala-betadcph
6946:tolhs-25methiaz-gly-betathiome
306947:ibhs-nme35pyr-bala-csdap
6948:bhs-ithiadiaz-ala-betamesu
6949:thpym-26py-gly-betahdcph
6950:2py-ithiadiaz-bala-betapy
6951;tolhs-oxadiaz-gly-asppha
356952:bhs-nme35pyr-nmgly-betaanaphth
6953:phhs-25thiaz-bala-betahmo
6954:bhs-25oxaz-gly-betadhbfu

CA 02371604 2001-10-24
1N000166618 PCTIEP00/03469
-214
6955:bhs-24thiaz-nmgly-betacthioph
6956:tolhs-25thiaz-bala-ibsdap
6957:tolhs-nme35pyr-bala-beta23meoph
6958:bim-24thioph-gly-betadcph
6959:tolhs-24thioph-bala-betahc
6960:bhs-25thiaz-bala-betahcbph
6961:tolhs-24thiaz-bala-betadhbfu
6962:ibhs-25methiaz-bala-betadtrif
6963:phhs-25methiaz-bala-beta23meoph
6964:phhs-nme35pyr-bala-betampy
6965:bhs-25thiaz-gly-betahcbph
6966:bhs-ithiadiaz-ala-zdap
6967:tolhs-25thiaz-bala-betaimid
6968:phhs-25thiaz-gly-betaamibe
6969:bim-ithiadiaz-ala-betapy
6970:bhs-42pym-ala-betainyl
6971:tolhs-25thiaz-bala-betafu2
6972:2pmhs-24thioph-gly-betathiome
6973:imhs-24thiaz-giy-zdap
6974:dhim-52thiaz-gly-betapy
6975:tolhs-24thioph-bala-betamesu
6976:phhs-ithiadiaz-bala-betahmo
6977:gua-25thiaz-gly-betaibph
6978:ibhs-24thiaz-bala-betadito
6979:phhs-nme35pyr-gly-betambiph
6980:dhpyrr-25thioph-gly-betapy
6981:bhs-25thiaz-nmgly-beta13bendi
6982:bhs-42nmeim-gly-betaoxope
6983:bim-42pym-ala-betadcph
6984:tolhs-me24thioph-leu-psdap
6985:2py-42nmeim-leu-betapy
6986:phhs-oxadiaz-bala-betamesu
6987:tolhs-24thioph-bala-aspaba
6988:dhim-26py-ala-zdap
6989:bhs-oxadiaz-bala-betampy
6990:ibhs-25thiaz-bala-betamethioph
6991:2py-42pym-gly-betameph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-215-
6992:tolhs-ithiadiaz-bala-betadmph
6993:gua-24thiaz-gly-betahmo
6994:bhs-ithiadiaz-bala-betapym
6995:bhs-24thioph-ala-betacthioph
6996:bhs-24thiaz-bala-beta.hph
6997:phhs-ithiadiaz-gly-betadito
6998:phhs-me24oxaz-ala-betapy
6999:bhs-52thiaz-ala-betapy
7000:bhs-me25oxaz-ala-zdap
107001:ibhs-25oxaz-bala-betabenfu
7002:phhis-24thiaz-bala-beta34dcph
7003:ibhs-24thiaz-bala-betadcphch
7004:ibhs-25thiaz-gly-betatrif
7005:ibhs-oxadiaz-gly-betahbcph
157006:bhs-nme35pyr-bala-betaimid
7007:bhs-oxadiaz-bala-betaamibe
7008:phhs-25oxaz-bala-betafu2
7009:tolhs-24thioph-gly-betahbcph
7010:2py-25fur-bala-betapy
207011:2py-25oxaz-bala-betainy)
7012:tolhs-me25thiaz-leu-betaph
7013:bhs-ithiadiaz-bala-betadmph
7014:bhs-nme35pyr-gly-busu2be
7015:bhs-me24thiaz-gly-betadcph
257016:tolhs-oxadiaz-bala-suabu
7017:bhs-24thioph-ala-beta34meoph
7018:tolhs-24thiaz-bala-betabnaphth
7019:ibhs-25methiaz-gly-zdapee
7020:tolhs-24thiaz-bala-betacbph
307021:bhs-25thiaz-bala-betahni
7022:ibhs-oxadiaz-bala-betaheph
7023:phhs-25thiaz-bala-betapbiph
7024:ibhs-25oxaz-gly-betafu3
7025;tolhs-24thioph-bala-betadcph
357026:2py-me25thiaz-bala-beta34meoph
7027:tolhs-ithiadiaz-gly-betaomebendi
7028:tolhs-24thiaz-bala-psdapch

CA 02371604 2001-10-24
W000/66618 PCT/EP00103469
-216
7029; phhs-nme35pyr-bala-beta23meoph
7030: bhs-24thioph-gly-betadcphch
7031: phhs-nme35pyr-gly-betafph
7032: tolhs-24thioph-bala-betadcphtb
7033: bhs-nme35pyr-bala-betadmph
7034: bhs-oxadiaz-gly-betadcphtb
7035: phhs-ithiadiaz-gly-betapyr
7036: dhim-24thiaz-gly-betameph
7037: bgua-24thiaz-gly-betameph
107038: bhs-24thiaz-ala-betapy
7039: tolhs-24thiaz-bala-betaet
7040: ibhs-25thiaz-gly-betadbph
7041: 2py-26py-gly-betaanaphth
7042: bhs-25oxaz-bala-betadhbfu
157043: phhs-25oxaz-gly-betamethi
7044: bim-24im-gly-psdap
7045: tolhs-25oxaz-gly-betadhbfu
7046: gua-24oxaz-gly-betahb
7047: phhs-oxadiaz-bala-betaph
207048: ibhs-24thioph-bala-betaomebendi
7049: bhs-24thiaz-ala-beta3quin
7050: bhs-25oxaz-bala-beta34meoph
7051: ibhs-25methiaz-gly-beta4bph
7052: bhs-nme35pyr-bala-betapbiph
257053: phhs-25methiaz-bala-psdap
7054: bhs-25methiaz-bala-betahcbph
7055: bhs-oxadiaz-gly-betafu3
7056: phhs-oxadiaz-bala-betaanaphth
7057: 2py-42nmeim-gly-zdap
307058: bhs-53pyrazo-leu-betadcph
7059: ibhs-25oxaz-bala-betahcbph
7060: gua-24thiaz-gly-betaol
7061: ibhs-nme35pyr-bala-aspaba
7062: impy-42nmeim-gly-betathioph
357063: tolhs-24thioph-bala-betahph
7064: bhs-24thiaz-bala-betamesu
7065: phhs-nme35pyr-giy-betathio3

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-217
7066: 2py-24thioph-bala-betapy
7067: phhs-25thiaz-gly-betadcphch
7068: phhs-ithiadiaz-gly-betabdimo
7069: bim-me24thioph-ala-betadcph
7070: phhs-25methiaz-bala-zdaptb
7071: tolhs-25oxaz-gly-betafbph
7072: bgua-25thiaz-gly-betameph
7073: thazep-25thioph-gly-betadcph
7074: 2py-me24oxaz-gly-zdap
7075: tolhs-24thioph-gly-betadtrif
7076: tolhs-ithiadiaz-gly-betal3bendi
7077: bhs-me25thioph-bala-psdap
7078: ibhs-nme35pyr-bala-betampy
7079: phhs-25oxaz-gly-betahni
7080: tolhs-24thioph-gly-betambiph
7081: 2py-25thiaz-hphe-psdap
7082: tolhs-25oxaz-bala-zdapch
7083: tolhs-nme35pyr-bala-beta3quin
7084: ibhs-25oxaz-bala-betahmph
7085: phhs-nme35pyr-gly-betadcphtb
7086: bhs-nme35pyr-gly-betadmph
7087: phhs-25methiaz-gly-betadmph
7088: ibhs-nme35pyr-gly-beta3quin
7089: ibhs-24thiaz-bala-betaibph
7090: bhs-25oxaz-bala-busu2be
7091: dhim-42pym-gly-zdap
7092: tolhs-25methiaz-bala-betatos
7093: phhs-nme35pyr-gly-beta13bendi
7094: bhs-24thioph-gly-betabph
7095: tolhs-oxadiaz-Bata-betaphethioa
7096: ibhs-nme35pyr-gly-betathiome
7097: bhs-oxadiaz-bala-betamesu
7098: bhs-oxadiaz-gly-zdapee
7099: phhs-oxadiaz-gly-beta3quin
7100: ibhs-25methiaz-gly-betaipr
7101: ibhs-nme35pyr-bala-betaphethioa
7102: gua-24oxaz-gly-betaol

CA 02371604 2001-10-24
W000166618 PCT/EP00103469
-218-
7103: tolhs-24thiaz-bala-betapyee
7104: bhs-ithiadiaz-nmgly-betacthioph
7105: phhs-oxadiaz-gly-betadcphtb
7106: tolhs-ithiadiaz-gly-betabnaphth
7107: ibhs-25oxaz-bala-betabmph
7108: bim-52thiaz-ala-psdap
7109: tolhs-25methiaz-gly-betamesu
7110: hyd-25oxaz-gly-betapy
7111: bhs-24thioph-bala-betapyee
7112:2py-26py-ala-betameph
7113: bim-25methiaz-gly-aspbzla
7114: ibhs-nme35pyr-gly-betadmph
7115: bim-25thiaz-bala-betadcph
7116: tolhs-24thioph-gly-betatrif
7117:phhs-24thiaz-giy-betamethioph
7118: tolhs-me24thiaz-ala-betadcph
7119: phhs-oxadiaz-gly-betadito
7120: tolhs-ithiadiaz-gly-beta34meoph
7121: bhs-ithiadiaz-gly-zdaptb
7122:impy-24thioph-bala-betah35dc
7123: ibhs-25oxaz-bala-betadbph
7124: 2py-25thioph-gly-betameph
7125: bim-25methiaz-bala-betahc
7126: tolhs-me24thioph-gly-betaph
7127:tolhs-oxadiaz-gly-betaftrif
7128: ibhs-oxadiaz-gly-betathiobe
7129: tolhs-nme35pyr-gly-beta35dbph
7130: ibhs-nme35pyr-bala-ibsdap
7131: phhs-25oxaz-gly-betahmph
7132:bhs-oxadiaz-ala-betadhbfu
7133: impy-25thiaz-bala-betamethi
7134: ibhs-nme35pyr-bala-psdapch
7135: bhs-me25oxaz-ala-psdap
7136: bhs-ithiadiaz-nmgly-betahph
7137:bhs-oxadiaz-ala-betacthioph
7138: dhim-26py-phe-zdap
7139: bhs-24thioph-bala-betah35dc

CA 02371604 2001-10-24
WOOOlfififi18 PCTIEP001034fi9
-219
7140:bhs-oxadiaz-bala-busu2be
7141:ibhs-25thiaz-gly-betaol
7142:bhs-oxadiaz-bala-betatbuph
7143:ibhs-nme35pyr-bala-betaipro
7144:bhs-me24thioph-leu-betaph
7145:ibhs-24thioph-gly-betampy
7146:phhs-oxadiaz-gly-psdap
7147:bhs-nme35pyr-gly-betamethioph
7148:bhs-25methiaz-baia-betathio3
7149:tolhs-24thiaz-bala-betainyl
7150:phhs-me25thioph-leu-beta34meoph
7151:2py-me25thiaz-leu-psdap
7152:bhs-ithiadiaz-bala-aspbzla
7153:thpy-42nmeim-gly-psdap
7154:phhs-24thioph-gly-betainyl
7155:phhs-25methiaz-gly-betambiph
7156:ibhs-nme35pyr-gly-suabu
7157:bhs-oxadiaz-gly-betameph
7158:impy-24thiaz-gly-beta34meoph
7159:ibhs-nme35pyr-bala-betatbuph
7160:ibhs-24thioph-gly-busu2be
7161:bhs-24thioph-gly-betamesu
7162:tolhs-ithiadiaz-gly-zdap
7163:gua-25thiaz-gly-betameph
7164:ibhs-nme35pyr-gly-betacthioph
7165:bhs-24im-leu-psdap
7166:ibhs-24thiaz-bala-betacbph
7167:bhs-oxadiaz-bala-betahni
7168:tolhs-24thiaz-gly-betapyee
7169:ibhs-24thioph-bala-betapyr
7170:phhs-nme35pyr-gly-beta34meoph
7171:bhs-24thiaz-ala-betadito
7172:bim-42nmeim-bala-betabthioph
7173:bhs-24thiaz-bala-betacbph
7174:ibhs-nme35pyr-bala-betabph
7175:phhs-ithiadiaz-gly-betahmph
7176:tolhs-ithiadiaz-bala-psdaptb

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-220
7177: ibhs-25oxaz-bala-betadmoph
7178: tolhs-me24oxaz-ala-zdap
7179: ibhs-ithiadiaz-bala-betahcbph
7180:, ibhs-25methiaz-bala-betathioph
7181: tolhs-25methiaz-gly-psdaptb
7182: tolhs-25oxaz-bala-betaph
7183: bhs-25thiaz-ala-betadmph
7184: bhs-24oxaz-bala-betadcph
7185: ibhs-24thioph-bala-psdapee
7186:bhs-ithiadiaz-gly-betapyr
7187: bhs-42nmeim-bala-betadito
7188: bim-24thiaz-bala-asppha
7189: bhs-24thiaz-gly-beta23meoph
7190: bhs-nme35pyr-nmgly-betacph
7191:bhs-24oxaz-leu-betapy
7192: impy-24thiaz-bala-betaphethioa
7193: phhs-ithiadiaz-gly-asppha
7194: phhs-25methiaz-gly-betapyr
7195: phhs-24thioph-gly-betaph
7196:dhim-26py-ala-psdap
7197: ibhs-24thioph-bala-betafu3
7198: ibhs-ithiadiaz-bala-betahb
7199: bhs-ithiadiaz-gly-betaomebendi
7200: phhs-25oxaz-bala-betabenfu
7201:tolhs-25thiaz-bala-betaipro
7202: phhs-25oxaz-bala-beta13bendi
7203: tolhs-oxadiaz-gly-betahc
7204: ibhs-25thiaz-bala-betadcphtb
7205: bhs-me24oxaz-bala-psdap
7206:ibhs-nme35pyr-bala-zdapee
7207: phhs-24thioph-bala-betainyl
7208: ibhs-24thioph-gly-zdap
7209: bhs-25methiaz-ala-betaanaphth
7210: tolhs-24thioph-gly-betapyee
7211:phhs-25thiaz-bala-ibsdap
7212: tolhs-24thiaz-gly-betabenfu
7213: bhs-oxadiaz-ala-beta23meoph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-221-
7214.bhs-25methiaz-ala-beta3quin
7215:phhs-25thiaz-gly-betaimid
7216:ibhs-nme35pyr-bala-beta34dcph
7217:ibhs-oxadiaz-gly-betahcbph
7218:ibhs-nme35pyr-gly-aspbzla
7219:2py-25oxaz-a.la-betapy
7220:gua-24thiaz-gly-betahdbph
7221:phhs-nme35pyr-bala-betaph
7222:bhs-nme35pyr-bala-betahdbph
107223:bhs-24thiaz-gly-betafph
7224:tolhs-25thiaz-bala-zdapch
7225:ibhs-24thiaz-gly-betapy
7226:tolhs-nme35pyr-bala-betadito
7227:phhs-25thiaz-bala-betafluo
157228:tolhs-24thiaz-gly-betaimid
7229:bhs-oxadiaz-gly-betafphe
7230:tolhs-me24thiaz-giy-betaph
7231:bim-53pyrazo-leu-psdap
7232:thazep-26py-gly-betainyl
207233:tolhs-nme35pyr-bala-betafluo
7234:tolhs-25methiaz-bala-betal3bendi
7235:bhs-25thioph-bala-psdap
7236:2pmhs-24thiaz-gly-betathiome
7237:2py-25oxaz-gly-betabthioph
257238:bhs-25thiaz-bala-betaoxope
7239:bhs-25oxaz-gly-betapych
7240:ibhs-25oxaz-gly-betahmph
7241:bhs-25oxaz-gly-betaet
7242:gua-26py-gly-betainyl
307243:bim-53pyrazo-gly-betadcph
7244:2py-25oxaz-bala-aspaba
7245:bhs-me25thioph-bala-betadcph
7246:ibhs-25methiaz-bala-betabpy
7247:bhs-24oxaz-gly-psdap
357248:bhs-25thiaz-bala-zdapch
7249:tolhs-24thiaz-bala-betaimid
7250:ibhs-24thioph-gly-beta34meoph

CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-222-
7251:tolhs-25methiaz-bala-betaipr
7252:bhs-nme35pyr-bala-betadcphee
7253:tolhs-oxadiaz-gly-betabph
7254:gua-24thiaz-gly-betaheph
7255:tolhs-nme35pyr-gly-zdaptb
7256:ibhs-25oxaz-bala-betahmo
7257:bim-me25oxaz-leu-beta34meoph
7258:2 py-24 i m-al a-beta
py
7259:bhs-24thiaz-nmgly-betainyl
107260:phhs-25thiaz-bala-betaipr
7261:bhs-24thiaz-gly-asppha
7262:2py-53pyrazo-leu-betadcph
7263:bhs-me24thioph-bala-betadcph
7264:dhim-26py-gly-betameph
157265:bhs-nme35pyr-ala-betamesu
7266:ibhs-25oxaz-gly-betabpy
7267:bhs-thiadiaz-gly-psdap
7268:bim-25methiaz-leu-zdap
7269:phhs-24thiaz-bala-betabnaphth
207270:ibhs-nme35pyr-gly-betadmoph
7271:2py-25th iaz-bala-betaheph
7272:dhpyrr-24thioph-gly-betapy
7273:phhs-me24thiaz-gly-betadcph
7274:tolhs-24thioph-gly-betahc
257275:bhs-24thiaz-gly-betahdbph
7276:bim-25oxaz-gly-betaph
7277:bim-nme35pyr-bala-aspbzla
7278:tolhs-nme35pyr-gly-zdap
7279:bhs-25methiaz-bala-psdapee
307280:2py-me24thiaz-leu-betapy
7281:bhs-oxadiaz-nmgly-beta3quin
7282:tolhs-24thiaz-gly-betahph
7283:bhs-25thiaz-phg-betameph
7284:tolhs-me25oxaz-leu-betapy
357285:2py-24thioph-bala-betafluo
7286:tolhs-25oxaz-bala-betaheph
7287:ibhs-25thiaz-bala-betabenfu

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-223
7288:phhs-nme35pyr-gly-ibsdap
7289:ibhs-24thioph-bala-betamethi
7290:ibhs-24thioph-bala-betaphethio
7291:ibhs-24thioph-gly-suabu
7292:bhs-25methiaz-bala-betabph
7293:2py-25methiaz-bala-betabnaphth
7294:tolhs-24thioph-bala-betahni
7295:bhs-nme35pyr-gly-betainyl
7296:ibhs-25methiaz-gly-betadito
7297:impy-25methiaz-gly-betacbph
7298:ibhs-oxadiaz-giy-betafphe
7299:bhs-oxadiaz-gly-betambiph
7300:bhs-nme35pyr-ala-betathio3
7301:bhs-25methiaz-gly-betapytb
7302:2py-25oxaz-bala-zdap
7303:phhs-24thiaz-gly-betahmo
7304:bim-24thioph-ala-psdap
7305:bim-me24oxaz-ala-betadcph
7306:bhs-24thioph-gly-betafu2
7307:ibhs-25thiaz-gly-betapytb
7308:ibhs-24thioph-bala-betameph
7309:phhs-oxadiaz-gly-betafu3
7310:ibhs-25thiaz-gly-betambiph
7311:ibhs-oxadiaz-gly-betathioph
7312:phhs-25methiaz-bala-betahbcph
7313:bim-24thiaz-gly-zdap
7314:bhs-25fur-baia-betadcph
7315:tolhs-oxadiaz-bala-betatrif
7316:bhs-24im-bala-betadcph
7317:tolhs-25methiaz-bala-zdap
7318:phhs-ithiadiaz-gly-betadcphee
7319:ibhs-25methiaz-bala-betaftrif
7320:tolhs-nme35pyr-gly-betapy
7321:phhs-25methiaz-gly-betabmph
7322:dhthi-42nmeim-baia-psdap
7323:tolhs-24thiaz-bala-beta34dcph
7324:tolhs-me25thiaz-leu-zdap

CA 02371604 2001-10-24
WOOOI66618 PCTlEP00103469
-224-
7325:2py-me25thiaz-bala-betaph
7326:bhs-25methiaz-ala-zdap
7327:bhs-24thioph-nmgly-betadmph
7328:bhs-24thiaz-leu-zdap
7329:ibhs-24thiaz-bala-betabdimo
7330:tolhs-25oxaz-gly-psdaptb
7331:phhs-me24thioph-ala-beta34meoph
7332:bim-25thiaz-phg-zdap
7333:ibhs-24thiaz-gly-betapym
7334:bim-me25thiaz-ala-betapy
7335:2py-42oxaz-bala-betapy
7336:bim-42oxaz-gly-betapy
7337:bhs-25oxaz-gly-betapytb
7338:bhs-25oxaz-gly-betapyee
7339:gua-42pym-gly-betabdimo
7340:bhs-26py-gly-betameph
7341:impy-26py-gly-psdap
7342:bhs-25oxaz-bala-betabediox
7343:tolhs-oxadiaz-bala-zdapee
7344:bhs-nme35pyr-gly-betathiobe
7345:tolhs-25methiaz-gly-betaomebendi
7346:ibhs-24thioph-bala-betampy
7347:ibhs-24thiaz-bala-betapbiph
7348:ibhs-24thioph-bala-psdapch
7349:phhs-24thiaz-bala-betaet
7350:bhs-25methiaz-bala-betaoxaz
7351:bhs-me24thioph-leu-betadcph
7352:2py-25thioph-bala-betadcph
7353:tolhs-ithiadiaz-gly-betathiobe
7354:bhs-25methiaz-bala-betathiome
7355:bhs-oxadiaz-gly-betaoxope
7356:bhs-24thiaz-bala-betabnaphth
7357:phhs-nme35pyr-bala-betahph
7358:ibhs-25thiaz-gly-zdaptb
7359:bhs-oxadiaz-ala-betahph
7360:ibhs-42nmeim-gIy-betameph
7361:ibhs-24thioph-bala-betaol

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-225
7362:tolhs-24thioph-bala-betah35dc
7363:ibhs-24thiaz-gly-betadcphtb
7364:bhs-25thiaz-gly-betabenfu
7365:tolhs-ithiadiaz-bala-betaoxope
7366:ibhs-oxadiaz-gly-betaheph
7367:bhs-24thiaz-ala-betacthioph
7368:ibhs-24thioph-gly-betapbiph
7369:bhs-oxadiaz-nmgly-betathio3
7370:bim-me25thiaz-ala-betaph
7371:ibhs-oxadiaz-gly-betahph
7372:gua-42pym-gly-betampy
7373:tolhs-25oxaz-gly-betafu2
7374:phhs-nme35pyr-bala-betaoxope
7375:ibhs-nme35pyr-bala-betaimid
7376:bhs-25oxaz-gly-psdapee
7377:bhs-25thiaz-nmgly-betacph
7378:tolhs-24thioph-bala-aspbzla
7379:ibhs-25methiaz-gly-psdapee
7380:tolhs-25thiaz-gly-betafph
7381:phhs-ithiadiaz-gly-betaphethio
7382:ibhs-ithiadiaz-bala-betafu3
7383:ibhs-25oxaz-bala-betadcphee
7384:phhs-25methiaz-gly-betaanaphth
7385:phhs-ithiadiaz-gly-zdapee
7386:bim-ithiadiaz-gly-aspibua
7387:phhs-25oxaz-bala-betaheph
7388:tolhs-25methiaz-gly-zdaptb
7389:bhs-oxadiaz-ala-betainyl
7390:tolhs-24thioph-gly-ibsdap
7391:2py-nme35pyr-gly-zdap
7392:bim-24thiaz-bala-betahc
7393:2py-me25thioph-bala-zdap
7394:imhs-25oxaz-bala-psdap
7395:bhs-24thioph-bala-betahni
7396:tolhs-24thioph-gly-betaet
7397:ibhs-25thiaz-gly-betahdbph
7398:phhs-nme35pyr-gly-psdapee

CA 02371604 2001-10-24
W0001666'18 PCTIEP00103469
-226-
7399:phhs-oxadiaz-gly-betahbcph
7400;hyd-24thioph-bala-betameph
7401:phhs-25thiaz-bala-busu2be
7402:tolhs-24thioph-gly-betahph
7403:2py-24thioph-bala-betaheph
7404:tolhs-nme35pyr-bala-beta13bendi
7405:bhs-ithiadiaz-gly-betahb
7406:bhs-oxadiaz-bala-betaibph
7407:ibhs-25methiaz-gly-betafphe
7408:phhs-24thiaz-gly-betahph
7409:2py-24thioph-leu-psdap
7410:phhs-nme35pyr-bala-betadcphtb
7411:ibhs-24thiaz-gly-betadcphch
7412:2py-24thiophme-ala-betapy
7413:bhs-24thioph-bala-psdaptb
7414:ibhs-25methiaz-bala-betabenfu
7415:2py-ithiadiaz-leu-betapy
7416:bim-42nmeim-leu-psdap
7417:gua-42pym-gly-betahmph
7418:phhs-25methiaz-gly-betabpy
7419:tolhs-24thioph-gly-betaamibe
7420:bhs-25oxaz-bala-psdapee
7421:2pmhs-25methiaz-bala-betamethioph
7422:dimethpym-24thiaz-gly-betahdcph
7423:bhs-24thiaz-bala-betah35dc
7424:tolhs-24thioph-bala-betabenfu
7425:bim-24thioph-ala-betadcph
7426:phhs-25methiaz-bala-betamesu
7427:bhs-nme35pyr-bala-betathiobe
7428:phhs-ithiadiaz-gly-zdap
7429:phhs-ithiadiaz-bala-betameph
7430:tolhs-nme35pyr-bala-betambiph
7431:bhs-35fur-leu-betapy
7432:phhs-25thiaz-gly-betaanaphth
7433:bhs-me24thiaz-gly-betaph
7434:bhs-25methiaz-bala-betameph
7435:ibhs-nme35pyr-bala-psdaptb

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-227-
7436:phhs-me24thioph-bala-beta34meoph
7437:bhs-25thiaz-gly-betaomebendi
7438:bhs-25thiaz-gly-betadbph
7439:bhs-25methiaz-gly-betamethi
7440:gua-24oxaz-gly-betaet
7441:phhs-24thioph-gly-suabu
7442:bhs-42nmeim-bala-beta35dbph
7443:ibhs-25thiaz-gly-betahmo
7444:bhs-24thiaz-gly-zdapee
107445:ibhs-24thiaz-bala-betahdbph
7446:ibhs-24thioph-gly-betahb
7447:bim-25oxaz-gly-betadtrif
7448:bhs-24thioph-ala-betahph
7449:bhs-25oxaz-leu-psdap
157450:bhs-nme35pyr-bala-betainyl
7451:bhs-ithiadiaz-ala-beta3quin
7452:phhs-24thiaz-bala-betahdcph
7453:bim-me25thiaz-leu-betapy
7454:2py-25thiaz-gly-betainyl
207455:tolhs-25oxaz-gly-beta13bendi
7456:tolhs-24thiaz-bala-beta4bph
7457:tolhs-ithiadiaz-bala-betampy
7458:bhs-25oxaz-gly-betafphe
7459:tolhs-ithiadiaz-bala-betahmph
257460:ibhs-25thiaz-gly-betaphethioa
7461:ibhs-24thioph-bala-betacph
7462:bhs-25methiaz-bala-betaamibe
7463:phhs-me25thioph-leu-psdap
7464:2py-me25thiaz-leu-beta34meoph
307465:ibhs-ithiadiaz-bala-betaamibe
7466:phhs-oxadiaz-bala-betaoxaz
7467:phhs-nme35pyr-gly-betaphethioa
7468:bhs-24thiaz-gly-betabpy
7469:tolhs-ithiadiaz-bala-betamethioph
357470.bim-24oxaz-leu-psdap
7471:bhs-thiadiaz-leu-psdap
7472:2py-oxadiaz-gly-aspaba

CA 02371604 2001-10-24
W~00166618 PCTlEP00I03469
-228-
7473:2py-42nmeim-gly-psdap
7474:impy-25methiaz-gly-betathiobe
7475:tolhs-25oxaz-bala-betampy
7476:ibhs-25oxaz-bala-aspbzla
7477:ibhs-25thiaz-bala-betaamibe
7478:phhs-24thioph-gly-betabmph
7479:ibhs-25thiaz-bala-betaet
7480:ibhs-25methiaz-bala-betaoxope
7481:bhs-nme35pyr-bala-betaibph
107482:tolhs-25oxaz-gly-betapbiph
7483:2py-25methiaz-bala-suabu
7484:tolhs-ithiadiaz-gly-betadcph
7485:2pmhs-42nmeim-gly-betaoxaz
7486:ibhs-25methiaz-bala-psdaptb
157487:bhs-25methiaz-bala-betaomebendi
7488:impy-25oxaz-gly-beta23meoph
7489:bhs-nme35pyr-gly-psdaptb
7490:bhs-24thioph-gly-betacph
7491:bhs-25oxaz-bala-aspibua
207492:tolhs-nme35pyr-bala-zdapee
7493:bhs-25methiaz-bala-betamesu
7494:2py-42oxaz-leu-betadcph
7495:ibhs-25thiaz-gly-betadmoph
7496:bhs-nme35pyr-bala-betaipro
257497:bim-42nmeim-gly-betainyl
7498:phhs-nme35pyr-gly-betaph
7499:tolhs-25methiaz-bala-betafph
7500:tolhs-24thioph-bala-psdap
7501:bhs-25thioph-ala-betameph
307502:tolhs-25oxaz-bala-betaoxaz
7503:phhs-25thiaz-bala-betahmofu
7504:bim-24thioph-gly-asppha
7505:phhs-25oxaz-bala-betatbuph
7506:bhs-oxadiaz-ala-betamesu
357507:ibhs-24thioph-gly-betabthioph
7508:2pmhs-24thiaz-bala-betahph
7509:phhs-25oxaz-gly-betabthioph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-229
7510:phhs-24thioph-bala-betaoxope
7511:bhs-ithiadiaz-bala-ibsdap
7512:ibhs-25thiaz-gly-zdapee
7513:bhs-25oxaz-bala-betafbph
7514:tolhs-25oxaz-gly-betabthioph
7515:bhs-me25thioph-bala-beta34meoph
7516:impy-25methiaz-gly-betaipr
7517:phhs-25thiaz-gly-betadcphtb
7518:bhs-24thiaz-bala-betaipr
107519:tolhs-24thioph-gly-psdapch
7520:bhs-me24oxaz-gly-betapy
7521:phhs-nme35pyr-bala-betathio3
7522:bhs-nme35pyr-gly-betabenfu
7523:phhs-25methiaz-bala-betadito
157524:ibhs-nme35pyr-bala-betadcphtb
7525:tolhs-24thioph-gly-aspaba
7526:2py-35thioph-bala-psdap
7527:bim-me25thiaz-bala-psdap
7528:gua-25thioph-gly-beta3quin
207529:gua-42pym-gly-betathiome
7530:phhs-25methiaz-gly-beta23meoph
7531:phhs-25thiaz-gly-betadbph
7532:tolhs-24thiaz-gly-ibsdap
7533;bim-25oxaz-ala-betadcph
257534:2py-25thiaz-bala-psdap
7535:phhs-ithiadiaz-bala-betahbcph
7536:ibhs-ithiadiaz-gly-betahmo
7537:bhs-25oxaz-gly-betadito
7538:2pmhs-25oxaz-gly-betacthioph
307539:bhs-me25thiaz-ala-beta34meoph
7540:ibhs-25thiaz-gly-betahmph
7541:bhs-nme35pyr-bala-betahc
7542:tolhs-24thioph-bala-busu2be
7543:ibhs-nme35pyr-gly-betahph
357544:bim-24thioph-gly-betaanaphth
7545:phhs-oxadiaz-bala-csdap
7546:phhs-25thiaz-gly-psdaptb

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-230
7547:bim-24oxaz-leu-betadcph
7548:phhs-24thiaz-bala-betahc
7549:phhs-25methiaz-bala-aspaba
7550:tolhs-25oxaz-gly-betacph
7551:bhs-24thiaz-gly-betahni
7552:ibhs-25oxaz-gfy-busu2be
7553:bhs-24thiaz-bala-betahmofu
7554:phhs-25oxaz-bala-betaipro
7555:impy-24thiaz-gly-betacbph
7556:ibhs-25methiaz-bala-betafph
7557:tofhs-24thiaz-gly-betathiobe
7558:ibhs-ithiadiaz-bala-beta4bph
7559:bhs-24thiaz-bala-betambiph
7560:gua-24thiaz-gly-betathiobe
7561:bgua-24thiaz-gly-betapy
7562:tolhs-ithiadiaz-bala-betathioph
7563:bhs-42pym-gly-betacph
7564:phhs-ithiadiaz-bala-betadito
7565:bhs-nme35pyr-bala-aspaba
7566:bhs-24thioph-bala-betaipr
7567:ibhs-24thioph-bala-betaanaphth
7568;dhpyrr-26py-gly-betapy
7569:tolhs-25methiaz-bala-betaomebendi
7570:bhs-ithiadiaz-bala-betahph
7571:bhs-nm35pyr-gly-beta4bph
7572:bim-oxadiaz-gly-aspbzla
7573:phhs-25thiaz-bala-betabnaphth
7574:phhs-24thioph-gly-betaipro
7575:phhs-25thiaz-gly-beta4bph
7576:ibhs-25thiaz-bala-betathio3
7577:ibhs-25thiaz-bala-betabpy
7578:phhs-oxadiaz-bala-beta34dcph
7579:bhs-25oxaz-bala-betaomebendi
7580:tolhs-24thiaz-gly-betamethioph
7581:2py-42nmeim-bala-betapbiph
7582:ibhs-oxadiaz-gly-beta35dbph
7583:bhs-nme35pyr-bala-beta23meoph

CA 02371604 2001-10-24
W000166618 PCTIEP00/03469
-231
7584: tolhs-nme35pyr-gly-betabthioph
7585: tolhs-oxadiaz-gly-betabmph
7586: bhs-25thiaz-ala-betadcph
7587: 2py-42pym-ala-betameph
7588: bhs-24thiaz-bala-betameph
7589: ibhs-25thiaz-gly-betaibph
7590: tolhs-ithiadiaz-gly-betambiph
7591: bhs-triaz-leu-betadcph
7592: tolhs-25oxaz-gly-betaphethio
7593:tolhs-24thioph-bala-betahdcph
7594: tolhs-25oxaz-gly-betafluo
7595: bhs-me25oxaz-ala-beta34meoph
7596: bhs-24thioph-bala-zdap
7597: ibhs-oxadiaz-gly-betaipr
7598:tolhs-25methiaz-bala-betahdbph
7599: bhs-me25thioph-leu-zdap
7600: tolhs-24thiaz-gly-betadmoph
7601: phhs-25thiaz-gly-betaftrif
7602: tolhs-25methiaz-gly-betahmofu
7603:bhs-oxadiaz-bala-betaphethioa
7604: phhs-25thiaz-bala-betadmph
7605: phhs-24thiaz-gly-betapych
7606: bhs-me24thiaz-gly-beta34meoph
7607: bhs-24thioph-gly-betahni
7608:bhs-25thiaz-gly-betadcphch
7609: tolhs-oxadiaz-bala-betamethi
7610: ibhs-25methiaz-gly-betameph
7611: phhs-25oxaz-gly-beta4bph
7612: tolhs-24thiaz-gly-aspibua
7613:2py-24thiaz-gly-betatbuph
7614: phhs-oxadiaz-gly-betah35dc
7615: phhs-ithiadiaz-gly-betapy
7616: bhs-25oxaz-bala-betabthioph
7617: tolhs-oxadiaz-gly-betathiobe
7618:bhs-25thiaz-gly-betahdbph
7619: ibhs-25oxaz-gly-betahc
7620: 2py-35thioph-bala-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-232
7621:bim-me24thiaz-leu-beta34meoph
7622:tolhs-24thiaz-bala-betafphe
7623:2py-26py-phg-zdap
7624:bhs-24thioph-gly-beta34meoph
7625:tolhs-oxadiaz-bala-betamethioph
7626:phhs-nme35pyr-bala-betamethi
7627:bhs-ithiadiaz-ala-betahph
7628:phhs-25oxaz-gly-betafu2
7629:bhs-nme35pyr-bala-zdapch
107630:bhs-24thioph-gly-aspaba
7631:tolhs-25thiaz-gly-betadrnoph
7632:tolhs-24thioph-bala-betatos
7633:bhs-25oxaz-bala-betadito
7634:bhs-53pyrazo-leu-psdap
157635:ibhs-oxadiaz-gly-betaipro
7636:2py-12me35pyr-gly-asppha
7637:thpy-25thiaz-gly-betadcph
7638:gua-25thiaz-gly-betaftrif
7639:bim-nme35pyr-bala-zdap
207640:phhs-25thiaz-gly-betapym
7641:bim-42nmeim-ala-psdap
7642:bhs-24thioph-bala-beta35dbph
7643:tolhs-25oxaz-bala-betafph
7644:tolhs-25methiaz-gly-betaimid
257645:phhs-me25oxaz-bala-beta34meoph
7646:bim-me25thioph-leu-betapy
7647:phhs-24thiaz-gly-betaheph
7648:ibhs-25oxaz-bala-csdap
7649:tolhs-me24oxaz-leu-zdap
307650:bhs-oxadiaz-bala-betah35dc
7651:bhs-24thioph-nmgly-beta3quin
7652:tolhs-25oxaz-bala-psdaptb
7653:bhs-nme35pyr-gly-betaibph
7654:bhs-oxadiaz-bala-betafluo
357655:dimethpym-25oxaz-bala-betapy
7656:tolhs-nme35pyr-bala-betafu2
7657:phhs-nme35pyr-bala-betatbuph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-233
7658:bhs-25oxaz-bala-psdap
7659:bim-oxadiaz-gly-aspaba
7660:tolhs-ithiadiaz-gly-betabdimo
7661:bhs-24thioph-bala-betafphe
7662:tolhs-25oxaz-gly-busu2be
7663:bim-35pyrazo-ala-zdap
7664:impy-24thiaz-bala-busu2be
7665:gua-24thiaz-gly-betatrif
7666:phhs-me25oxaz-gly-betadcph
107667:phhs-me24thioph-leu-zdap
7668:phhs-24thioph-gly-betadcph
7669:tolhs-ithiadiaz-bala-betatos
7670:bhs-ithiadiaz-gly-betafphe
7671:phhs-ithiadiaz-bala-betadcphtb
157672:bhs-24thioph-bala-betahbcph
7673:bhs-ithiadiaz-gly-zdapch
7674:bim-42nmeim-ala-zdap
7675:tolhs-25methiaz-gly-betadcphtb
7676.tolhs-nme35pyr-gly-betafu3
207677:bhs-24thiaz-phg-betapy
7678:ibhs-ithiadiaz-gly-suabu
7679:dhpyrr-25oxaz-bala-betadcph
7680:ibhs-oxadiaz-gly-betapbiph
7681:ibhs-25oxaz-bala-betathiome
257682:hts-24oxaz-gly-betapy
7683:tolhs-25oxaz-gly-psdapch
7684:phhs-25methiaz-gly-betal3bendi
7685:bim-25thiaz-bala-zdap
7686:gua-42pym-gly-betahdcph
307687:phhs-25oxaz-gly-betaanaphth
7688:phhs-ithiadiaz-gly-betathio3
7689:bhs-nme35pyr-gly-beta34meoph
7690;bhs-25thiaz-gly-betafu3
7691:bim-24thiaz-ala-betapy
357692:tolhs-ithiadiaz-gly-betabpy
7693:ibhs-25thiaz-bala-beta4bph
7694:tolhs-nme35pyr-bala-betadmph

CA 02371604 2001-10-24
WOOO166618 PCTIEP00103469
-234-
7695:ibhs-24thioph-gly-betathio3
7696:bhs-24thioph-gly-betainyl
7697:ur-42nmeim-gly-psdap
7698:phhs-25oxaz-bala-betacthioph
7699:bim-24thioph-bala-aspaba
7700:bim-me24oxaz-bala-betapy
7701:ibhs-nme35pyr-bala-betadmph
7702:ibhs-24thiaz-bala-betadcph
7703:tolhs-25oxaz-gly-betabdimo
107704:bhs-nme35pyr-gly-beta23meoph
7705:bhs-nme35pyr-bala-betafu3
7706.cima-42pym-gly-betainyl
7707:tvlhs-oxadiaz-bala-betadcphtb
7708:2py-me24thioph-ala-zdap
157709:phhs-25oxaz-bala-betaet
7710:ibhs-oxadiaz-gly-betambiph
7711:bhs-ithiadiaz-bala-betaet
7712:gua-24oxaz-gly-betadcph
7713:tolhs-25methiaz-gly-betaph
207714:bhs-25thiaz-gly-betacph
7715:impy-25oxaz-bala-betaoxaz
7716:ibhs-oxadiaz-bala-beta35dbph
7717:phhs-ithiadiaz-bala-beta34meoph
7718:2py-35thioph-gly-psdap
257719:tolhs-nme35pyr-bala-betadcphtb
7720:dhim-52thiaz-gly-betainyl
7721:bhs-25methiaz-nmgly-betathioph
7722:tolhs-24thioph-gly-betaimid
7723:bhs-25methiaz-bala-betaheph
307724:phhs-nme35pyr-bala-betahdbph
7725:phhs-25thiaz-gly-psdap
7726:bhs-ithiadiaz-gly-betadcph
7727:tolhs-nme35pyr-bala-betabpy
7728:ibhs-25thiaz-bala-psdaptb
357729:2py-25thiaz-gly-aspbzla
7730:phhs-25oxaz-gly-betabph
7731:phhs-25oxaz-gly-betamesu

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-235-
7732:bhs-oxadiaz-ala-betabnaphth
7733:bhs-nme35pyr-bala-betafbph
7734:tolhs-24thioph-bala-betadito
7735:ibhs-25thiaz-bala-psdap
7736:tolhs-25thiaz-bala-betabdimo
7737:bhs-25thiaz-gly-zdapch
7738:phhs-me25thiaz-bala-betapy
7739:phhs-24thiaz-gly-betapbiph
7740:tolhs-oxadiaz-bala-betaphethio
107741:hs-26py-gly-betapy
7742:bhs-24thioph-gly-aspibua
7743:phhs-nme35pyr-bala-betabdimo
7744:gua-24thiaz-gly-betathio3
7745:bhs-25methiaz-gly-betabpy
157746:dhim-42pym-gly-psdap
7747:ibhs-25thiaz-gly-asppha
7748:tolhs-nme35pyr-gly-betathiobe
7749:2py-me24oxaz-leu-psdap
7750:phhs-25thiaz-bala-zdaptb
207751:2py-42pym-ala-betapy
7752:phhs-25methiaz-bala-betahdcph
7753:phhs-25oxaz-gly-psdapee
7754:ibhs-24thiaz-gly-betambiph
7755:phhs-oxadiaz-gly-zdap
257756:bhs-35thioph-leu-psdap
7757:tolhs-ithiadiaz-gly-betathioph
7758:bim-25fur-leu-zdap
7759:gua-24thiaz-gly-betadmph
7760:phhs-ithiadiaz-gly-betatrif
307761:gua-42pym-gly-betapy
7762:phhs-25oxaz-bala-betaol
7763:bim-oxadiaz-gly-zdap
7764:ibhs-oxadiaz-gly-betainyl
7765:bhs-25methiaz-bala-betadbph
357766:phhs-24thiaz-gly-betabdimo
7767:bhs-25thiaz-nmgly-beta23meoph
7768:bhs-25thiaz-gly-betathiome

CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-236-
7769:tolhs-me25thiaz-ala-betadcph
7770:bhs-me25oxaz-bala-psdap
7771:bhs-nme35pyr-bala-betadbph
7772:bhs-25methiaz-gly-betathioph
7773:bhs-24thioph-nmgly-beta34dcph
7774:ibhs-25methiaz-bala-betadmoph
7775:phhs-24thioph-bala-betaheph
7776:bhs-25oxaz-bala-betabph
7777:bhs-oxadiaz-ala-betahmph
107778:phhs-nme35pyr-bala-betaimid
7779:ibhs-oxadiaz-bala-betapym
7780:ibhs-25thiaz-gly-betafphe
7781:2py-24thiaz-gly-psdap
7782:tolhs-24thiaz-gly-betathiome
157783:bhs-ithiadiaz-nmgly-betaoxaz
7784:thazep-24oxaz-gly-betapy
7785:phhs-oxadiaz-bala-psdap
7786:ibhs-25oxaz-gly-beta4bph
7787:phhs-25thiaz-gly-betapyee
207788:bhs-35thioph-gly-betapy
7789:2py-35fur-1 eu-psdap
7790:tolhs-24thioph-gly-aspibua
7791:tolhs-24thioph-bala-betaftrif
7792:bhs-25methiaz-gly-betahc
257793:tolhs-24thiaz-gly-psdapee
7794:bim-24thiaz-gly-betapy
7795:tolhs-25thiaz-bala-betaibph
7796:tolhs-me24thiaz-leu-betadcph
7797:2py-me24oxaz-bala-beta34meoph
307798:bhs-nme35pyr-nmgly-beta13bendi
7799:phhs-25oxaz-gly-betafphe
7800:bhs-nme35pyr-bala-betahph
7801.impy-25thiaz-gly-zdap
7802:gua-24oxaz-giy-betafluo
357803:phhs-ithiadiaz-gly-betaheph
7804.bhs-42nmeim-leu-betadcph
7805:phhs-nme35pyr-bala-busu2be

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-237
7806: bim-thiadiaz-leu-psdap
7807: dhim-52thiaz-ala-zdap
7808: bhs-24thioph-gly-betahdbph
7809: nmhs-24oxaz-gly-betapy
7810: gua-42pym-gly-betahb
7811: tolhs-ithiadiaz-gly-betathiome
7812: 2py-24thioph-bala-aspbzla
7813: bhs-25oxaz-gly-betathiobe
7814: tolhs-me24oxaz-bala-psdap
7815:bhs-24thioph-gly-betahmph
7816: tolhs-nme35pyr-bala-csdap
7817: ibhs-25thiaz-giy-betamesu
7818: phhs-24thiaz-bala-ibsdap
7819: 2py-thiadiaz-gly-betadcph
7820:2py-42oxaz-ala-betapy
7821: bhs-25thiaz-gly-psdapee
7822: bim-oxadiaz-ala-betadcph
7823: phhs-24thioph-bala-betadcphtb
7824: tolhs-25thiaz-gly-betampy
7825:ibhs-24thiaz-gly-betapych
7826: phhs-24thioph-gly-betamesu
7827: tolhs-me25thiaz-bala-psdap
7828: bim-25oxaz-bala-betadcph
7829: bhs-nme35pyr-gly-zdapch
7830:ibhs-25methiaz-gly-betaphethioa
7831: phhs-24thiaz-bala-aspaba
7832: tolhs-24thioph-bala-betahdbph
7833: bhs-me24thioph-leu-psdap
7834: phhs-25oxaz-gly-betathio3
7835:bhs-24thiaz-bala-beta4bph
7836: phhs-nme35pyr-gly-betatos
7837: ibhs-nme35pyr-bala-betaoxaz
7838: tolhs-24thioph-bala-betahbcph
7839: bhs-oxadiaz-gly-betahni
7840:phhs-25oxaz-bala-betaphethioa
7841: 2py-24thioph-bala-asppha
7842: tolhs-24thioph-gly-betaomebendi

CA 02371604 2001-10-24
W000166698 PCTlEP00103469
-238-
7843: tolhs-25oxaz-bala-betabediox
7844: impy-24thioph-bala-betamesu
7845: ibhs-24thiaz-bala-betathiome
7846: 2py-4.2nmeim-ala-betapy
7847: ibhs-24thiaz-bala-betaphethio
7848: phhs-24thioph-bala-betafbph
7849: phhs-me25thioph-ala-psdap
7850: bhs-nme35pyr-gly-betamethi
7851: bim-me25thivph-bala-beta34meoph
107852: bhs-24thioph-gly-betapyr
7853: ibhs-oxadiaz-gly-betaoxaz
7854: bhs-me24thioph-gly-betaph
7855: bhs-53pyrazo-ala-psdap
7856: phhs-oxadiaz-bala-betabdimo
157857: bhs-24thiaz-gly-betadtrif
7858: bim-25oxaz-leu-betadcph
7859: ibhs-ithiadiaz-gly-betapym
7860: bhs-nme35pyr-bala-beta3quin
7861: bhs-ithiadiaz-bala-betabdimo
207862: ibhs-oxadiaz-bala-betahmph
7863: tolhs-25methiaz-gly-betahmo
7864: ibhs-25methiaz-gly-betamethi
7865: ibhs-25thiaz-gly-aspaba
7866: bhs-oxadiaz-bala-betadcphch
257867: ibhs-ithiadiaz-bala-betapych
7868: bhs-24thiaz-gly-betabmph
7869: ibhs-ithiadiaz-gly-csdap
7870: bhs-25oxaz-ala-betameph
7871: bhs-25oxaz-gly-psdapch
307872: bhs-25thiaz-bala-beta35dbph
7873: bim-nme35pyr-bala-betadcph
7874: phhs-oxadiaz-bala-betadcph
7875: bim-24oxaz-leu-zdap
7876: bhs-ithiadiaz-gly-betaphethioa
357877: bhs-24thiaz-gly-betatho3
7878: tolhs-24thiaz-bala-betampy
7879: bhs-24thiaz-gly-betadito

CA 02371604 2001-10-24
W000166618 PCTlEP00/03469
-239
7880: bhs-me24thioph-bala-betaph
7881: 2py-24oxaz-ala-betainyl
7882: bhs-nme35pyr-bala-betabthioph
7883: phhs-25methiaz-bala-betathio3
7884: bhs-25thiaz-gly-betabph
7885: tolhs-25thiaz-gly-betadcph
7886: ibhs-24thioph-gly-betaimid
7887: ibhs-24thiaz-gly-betadcph
7888: ibhs-ithiadiaz-gly-psdapch
7889:tolhs-me25thiaz-ala-betaph
7890: thazep-42pym-gly-betadcph
7891: bhs-25thiaz-bala-betaol
7892: phhs-ithiadiaz-gly-psdapee
7893: bhs-24thioph-ala-betaipro
7894:bhs-24thioph-gly-betaftrif
7895: bhs-ithiadiaz-bala-betapych
7896: phhs-24thiaz-gly-betaamibe
7897: bhs-nme35pyr-giy-betaphethioa
7898: bim-25methiaz-gly-betaanaphth
7899:bim-thiadiaz-gly-zdap
7900: ibhs-25methiaz-gly-asppha
7901: tolhs-24thiaz-bala-betaphethio
7902: ibhs-24thiaz-bala-psdapch
7903: tolhs-25thiaz-gly-betaanaphth
7904:bhs-25methiaz-bala-betadcphee
7905: tolhs-me24oxaz-bala-betadcph
7906: bhs-25methiaz-bala-psdap
7907: tolhs-nme35pyr-bala-betafph
7908: ibhs-oxadiaz-gly-zdaptb
7909:bhs-oxadiaz-ala-betabpy
7910: bhs-nme35pyr-gly-betathiome
7911: 2py-42oxaz-gly-psdap
7912: bim-me24oxaz-gly-betapy
7913: tolhs-25oxaz-bala-betahb
7914:ibhs-ithiadiaz-gly-betah35dc
7915: phhs-25methiaz-bala-betapym
7916: bhs-ithiadiaz-gly-busu2be

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-240-
7917:tolhs-ithiadiaz-bala-betacph
7918:tolhs-24thioph-bala-zdapee
7919:bhs-me25thiaz-leu-psdap
7920:gua-24thiaz-gly-betabnaphth
7921:bhs-oxadiaz-gly-betaipr
7922:bhs-me25thiaz-bala-beta34meoph
7923:bhs-25thiaz-bala-betamethioph
7924:tolhs-24thiaz-bala-betadito
7925:ibhs-ithiadiaz-bala-betacbph
7926:phhs-24thiaz-gly-betafbph
7927:phhs-24thioph-gly-betacph
7928:phhs-25methiaz-bala-betainyl
7929:ibhs-nme35pyr-gly-betabthioph
7930:tolhs-24thiaz-bala-betahph
7931:tolhs-25oxaz-gly-betahcbph
7932:tolhs-me24oxaz-bala-beta34meoph
7933:tolhs-me25oxaz-leu-betaph
7934:bhs-nme35pyr-gly-betafu2
7935:bhs-me25oxaz-gly-beta34meoph
7936:tolhs-25thiaz-bala-betapyee
7937:ibhs-nme35pyr-bala-betaanaphth
7938:bhs-oxadiaz-ala-betathio3
7939:2py-25fur-ala-betapy
7940:tolhs-25oxaz-bala-csdap
7941:tolhs-nme35pyr-bala-aspibua
7942:4pmhs-25methiaz-bala-betameph
7943:bhs-nme35pyr-ala-betabnaphth
7944:phhs-24thiaz-gly-betabmph
7945:tolhs-24thiaz-gly-betaoxaz
7946:ibhs-ithiadiaz-bala-betambiph
7947:impy-25methiaz-bala-betah35dc
7948:tolhs-25oxaz-gly-betaet
7949:phhs-oxadiaz-bafa-betampy
7950:phhs-ithiadiaz-gly-betambiph
7951:bhs-nme35pyr-gly-betapytb
7952:phhs-ithiadiaz-bala-betabpy
7953:bim-25thioph-leu-zdap

CA 02371604 2001-10-24
WO00166618 PCTIEP00103469
-241
7954:bhs-24thiaz-ala-betafphe
7955:ibhs-nme35pyr-bala-betafu2
7956:bhs-24thiaz-bala-zdapee
7957:phhs-24thiaz-bala-betacthioph
7958:bim-53pyrazo-leu-zdap
7959:ibhs-24thiaz-bala-zdapee
7960:bim-me25thioph-gly-zdap
7961:ibhs-oxadiaz-bala-betacthioph
7962:tolhs-me25thioph-bala-psdap
7963:phhs-25thiaz-gly-betafu3
7964:ibhs-24thiaz-bala-betabenfu
7965:tolhs-25thiaz-gly-betacbph
7966:bhs-24thiaz-gly-betafbph
7967:bim-35fur-leu-betadcph
7968:bim-25oxaz-bala-betahph
7969:phhs-24thiaz-gly-beta34dcph
7970:ibhs-nme35pyr-gly-beta23meoph
7971:phhs-24thiaz-bala-betamethioph
7972:ibhs-25thiaz-gly-beta3quin
7973:bim-25thioph-leu-psdap
7974:bhs-25thiaz-gly-psdaptb
7975:bhs-ithiadiaz-bala-betambiph
7976:bhs-24thiaz-bala-betabthioph
7977:bhs-24thiaz-gly-beta34meoph
7978:bhs-24thioph-bala-betambiph
7979:bhs-ithiadiaz-ala-psdap
7980:phhs-25thiaz-gly-betapych
.7981:bhs-oxadiaz-bala-betaph
7982:2py-42oxaz-bala-zdap
7983:bhs-oxadiaz-gly-betadcphch
7984:bhs-25thiaz-gly-betabmph
7985:bhs-25methiaz-gly-betafu3
7986:bhs-nme35pyr-gly-betahmofu
7987:ibhs-oxadiaz-bala-psdap
7988:2py-me24thioph-ala-beta34meoph
7989:2py-nme35pyr-bala-betadcph
7990:phhs-24thioph-bala-betathio3

CA 02371604 2001-10-24
VIIOOOl66618 PCTIEP00103469
-242
7991: 2py-35th ioph-ala-betadcph
7992: phhs-24thioph-gly-betahcbph
7993: 2py-35fur-leu-betadcph
7994: ibhs-oxadiaz-bala-betadmph
7995. bhs-nme35pyr-gly-betaph
7996: ibhs-oxadiaz-bala-betapytb
7997: phhs-25thiaz-gly-zdap
7998: impy-25oxaz-gly-betahdbph
7999: bhs-me25oxaz-bala-betadcph
8000:bim-25fur-gly-zdap
8001: bhs-25oxaz-ala-betaipro
8002: bhs-24thioph-nmgly-betahmph
8003: tolhs-nme35pyr-gly-betamethi
8004: bhs-me25thiaz-ala-psdap
8005:gua-24thiaz-gly-betaphethioa
8006: bim-25methiaz-leu-betadcph
8007: ibhs-ithiadiaz-bala-csdap
8008: phhs-25oxaz-gly-aspaba
8009: tolhs-oxadiaz-gly-betathiome
8010:phhs-24thioph-gly-psdapee
8011: phhs-nme35pyr-gly-psdap
8012; bhs-25oxaz-nmgly-betameph
8013: tolhs-oxadiaz-gly-beta23meoph
8014: ibhs-24thiaz-bala-betathioph
8015:tolhs-24thiaz-gly-betaet
8016: bhs-25oxaz-ala-betacthioph
8017: tolhs-oxadiaz-gly-betahmofu
8018: phhs-24thioph-gly-betaet
8019: ibhs-25thiaz-bala-betabph
8020:tolhs-24thioph-bala-betampy
8021: bhs-25oxaz-gly-betahni
8022: bhs-25oxaz-gly-betahmofu
8023: bhs-me25thiaz-ala-betadcph
8024: pbhs-24thioph-bala-beta35dbph
8025:dhim-42pym-ala-psdap
8026: 2py-24thioph-gly-betatbuph
8027: bhs-oxadiaz-ala-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-243
8028: 2py-35thioph-leu-zdap
8029: phhs-oxadiaz-gly-betaimid
8030: phhs-nme35pyr-gly-betacph
8031: ibhs-nme35pyr-bala-zdap
8032: gua-26py-gly-betadmph
8033: phhs-25thiaz-gly-betaoxope
8034: ibhs-oxadiaz-gly-betaamibe
8035: phhs-24thioph-gly-betapyee
8036: 2py-35thioph-gly-betapy
8037:bhs-35fur-ala-betapy
8038: bhs-24thiaz-nmgly-betamesu
8039: phhs-nme35pyr-gly-betaanaphth
8040: bgua-42pym-gly-betainyl
8041: ibhs-24thiaz-bala-betafphe
8042:bhs-25thiaz-ala-betathio3
8043: tolhs-24thiaz-bala-betacthioph
8044: bhs-25fur-leu-betapy
8045: phhs-24thiaz-gly-betafu3
8046: phhs-24thiaz-gly-betahdcph
8047:tolhs-25thiaz-gly-aspibua
8048: phhs-25oxaz-bala-betapyee
8049: ibhs-oxadiaz-gly-aspaba
8050: phhs-25methiaz-bala-betafbph
8051: bhs-25oxaz-nmgly-betadito
8052:bhs-oxadiaz-bala-betapyee
8053: agua-25oxaz-bala-betameph
8054: bim-me25thioph-bala-betadcph
8055: tolhs-24thiaz-bala-betahb
8056: tolhs-me24thiaz-gly-psdap
8057:bhs-24thiaz-bala-betaphethioa
8058: 2py-25thiaz-leu-zdap
8059: ibhs-oxadiaz-gly-betah35dc
8060: tolhs-24thiaz-gly-beta4bph
8061: bhs-25methiaz-gly-betaipr
8062:tolhs-ithiadiaz-gly-betaibph
8063: dhim-23thioph-gly-betameph
8064: bhs-24thioph-bala-zdaptb

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-244
8065:ibhs-25oxaz-gly-betaibph
8066:bhs-oxadiaz-nmgly-betacthioph
8067:bim-me25thioph-gly-betapy
8068:bhs-24thioph-gly-betahbcph
8069:bim-me24oxaz-gly-betaph
8070:impy-25oxaz-bala-betahmo
8071:ibhs-25methiaz-gly-beta23meoph
8072:2py-ithiadiaz-bala-psdap
8073:phhs-24thiaz-gly-betatos
8074:bim-me24oxaz-leu-betaph
8075:2py-26py-gly-psdap
8076:bhs-24thiaz-ala-betathio3
8077:bhs-25thiaz-bala-betatrif
8078:bim-24thiaz-gly-aspibua
8079:phhs-oxadiaz-bala-betathiome
8080:tolhs-24thioph-gly-betaibph
8081:phhs-24thiaz-bala-betaphethio
8082:tolhs-ithiadiaz-bala-betaph
8083:bhs-24thiaz-bala-betathiome
8084:bhs-me25thioph-gly-zdap
8085:phhs-nme35pyr-gly-betathiome
8086:tolhs-ithiadiaz-gly-zdapee
8087:phhs-25oxaz-bala-betaamibe
8088:bim-24oxaz-bala-psdap
8089:phhs-25oxaz-bala-aspbzla
8090:bim-42oxaz-gly-zdap
8092:ibhs-25thiaz-bala-betatos
8092:ibhs-oxadiaz-bala-aspaba
8093:phhs-nme35pyr-gly-betadcph
8094:gua-24thiaz-gly-beta3quin
8095:2py-25oxaz-gly-betathiobe
8096:tolhs-25methiaz-bala-betabnaphth
8097:bhs-25oxaz-ala-betacph
8098:bhs-nme35pyr-bala-betahcbph
8099:bim-me24thioph-ala-betaph
8100:ibhs-25methiaz-bala-ibsdap
8101:bhs-25methiaz-leu-zdap

CA 02371604 2001-10-24
W400166618 PCTIEP00103469
-245
8102:bhs-25thiaz-ala-betadhbfu
8103:bim-42oxaz-gly-psdap
8104:bhs-25thiaz-gly-betabiph
8105:gua-25thioph-gly-betaipr
8106:phhs-24thioph-gly-betapych
8107:bhs-25oxaz-gly-beta23meoph
8108:tolhs-24thioph-bala-asppha
8109:bhs-24thiaz-gly-betaipro
8110:tolhs-ithiadiaz-bala-betahdcph
8111:bim-24thiaz-ala-zdap
8112:tolhs-25thiaz-bala-beta34meoph
8113:bhs-ithiadiaz-gly-betaipro
8114:tolhs-25thiaz-gly-betapych
8115:tolhs-24thioph-bala-aspibua
8116:bhs-nme35pyr-gly-betafbph
8117:dhim-52thiaz-ala-betadcph
8118:2py-35fur-ala-betadcph
8119:phhs-25thiaz-bala-zdap
8120:2pmhs-25thiaz-gly-betahbcph
8121:bhs-25thiaz-bala-betahph
8122:bhs-oxadiaz-bala-betathiobe
8123:bhs-25methiaz-ala-betathioph
8124:tolhs-25oxaz-gly-aspaba
8125:2py-24thiaz-g ly-beta35d
bph
8126:ibhs-ithiadiaz-gly-betahc
8127:bhs-oxadiaz-bala-betabdimo
8128.phhs-25oxaz-bala-betaphethio
8129:bhs-25oxaz-ala-beta13bendi
8130:phhs-ithiadiaz-bala-beta23meoph
8131:bhs-25methiaz-gly-betafph
8132:tolhs-24thiaz-gly-betaol
8133:tolhs-oxadiaz-gly-betaipro
8134:tolhs-25methiaz-gly-aspbzla
8135:ibhs-oxadiaz-gly-betaanaphth
8136:tolhs-oxadiaz-bala-betaoxope
8137:bhs-25methiaz-nmgly-betacthioph
8138:2pmhs-25thiaz-gly-betaph

CA 02371604 2001-10-24
W000166618 PCTlEP00l03469
-246
8139:bhs-25oxaz-gly-betadcphch
8140:bim-25oxaz-bala-betabmph
8141:bhs-nme35pyr-gly-betafphe
8142:bhs-ithiadiaz-bala-betatos
8143:phhs-24thiaz-gly-betamethi
8144:thpym-24oxaz-gly-zdap
8145:tolhs-me25thiaz-bala-beta34meoph
8146:tolhs-nme35pyr-bala-betaimid
8147:bhs-nme35pyr-ala-betainyl
8148:bhs-25oxaz-gly-betatbuph
8149:2py-42pym-ala-betadcph
8150:tolhs-24thioph-gly-betafph
8151:bim-me25oxaz-bala-betapy
8152:bim-25methiaz-bala-aspbzla
8153:2py-me25thiaz-ala-zdap
8154:tolhs-25thiaz-gly-psdaptb
8155:2py-52thiaz-ala-betadcph
8156:bhs-25oxaz-bala-betah35dc
8157:gua-24oxaz-gly-betaipro
8158:tolhs-me25thioph-ala-psdap
8159:gua-24thiaz-gly-betamethi
8160:bhs-nme35pyr-leu-betadcph
8161:bim-oxadiaz-gly-betapy
8162:bhs-35fur-ala-psdap
8163:bhs-25methiaz-gly-betapy
8164:ibhs-24thiaz-bala-beta13bendi
8165:tolhs-24thiaz-bala-beta3quin
8166:bhs-ithiadiaz-bala-betatrif
8167:bhs-ithiadiaz-gly-betahmph
8168:tolhs-ithiadiaz-gly-betaheph
8169:tolhs-24thioph-gly-betampy
8170:tolhs-25oxaz-gly-betathiome
8171:ibhs-nme35pyr-gly-betahdcph
8172:ibhs-oxadiaz-bala-betabediox
8173:phhs-25methiaz-bala-betadhbfu
8174:bhs-25methiaz-gly-betabnaphth
8175:bhs-ithiadiaz-bala-betacph

CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-247
8176:bhs-24thioph-bala-betadmph
8177:tolhs-nme35pyr-bala-betafu3
8178:phhs-25methiaz-gly-betahni
8179:ibhs-25methiaz-bala-betaphethioa
8180:tolhs-nme35pyr-bala-betamethioph
8181:tolhs-ithiadiaz-bala-betaphethio
8182:tolhs-25methiaz-gly-betaipro
8183:ibhs-24thiaz-gly-betaanaphth
8184:bhs-nme35pyr-bala-betabediox
8185:2pmhs-42nmeim-bala-betapym
8186:ibhs-25oxaz-gly-betaipro
8187:phhs-24thioph-gly-psdap
8188:bhs-25oxaz-nmgly-betathio3
8189:bhs-24thioph-bala-betadtrif
8190:tolhs-ithiadiaz-bala-betamethi
8191:tolhs-25methiaz-bala-betabenfu
8192:ibhs-24thioph-bala-betadmoph
8193:tolhs-25oxaz-gly-betahb
8194:tolhs-me24thiaz-gly-zdap
8195:phhs-oxadiaz-gly-betathioph
8196:bhs-25thiaz-gly-betafphe
8197:ibhs-24thioph-bala-betaipr
8198:gua-25thioph-gly-betapyr
8199:phhs-nme35pyr-gly-betameph
8200:ibhs-25oxaz-gly-zdap
8201:ibhs-25methiaz-gly-zdap
8202:bhs-24thiaz-ala-betainyl
8203:bhs-nme35pyr-bala-betathiome
8204:bhs-24thiaz-bala-betathiobe
8205:tolhs-24thiaz-bala-betapym
8206:tolhs-25methiaz-gly-betathioph
8207:tolhs-ithiadiaz-bala-betapym
8208:tolhs-25oxaz-bala-betaimid
8209:tolhs-ithiadiaz-bala-betaipro
8210:bhs-25thiaz-bala-beta13bendi
8211:2pmhs-24thioph-gly-betabpy
8212:ibhs-ithiadiaz-bala-betadcph

CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-248
8213: bhs-24thiaz-gly-betabnaphth
8214: bhs-25oxaz-bala-betahmno
8215: 2py-me24oxaz-leu-betaph
8216: tolhs-25methiaz-gly-betahph
8217: phhs-25oxaz-gly-betapyr
8218: bhs-25oxaz-nmgly-betafphe
8219: bim-25thiaz-gly-betameph
8220: bhs-oxadiaz-bala-aspbzla
8221: bim-25oxaz-gly-betahb
108222: phhs-me25thiaz-ala-zdap
8223: tolhs-me24oxaz-bala-betapy
8224: gua-24thiaz-gly-betahbcph
8225: bim-24oxaz-ala-betainyl
8226: 2pmhs-25oxaz-gly-betathio3
158227: bhs-25oxaz-bala-betadcphtb
8228: 2py-me24oxaz-gly-betaph
8229: bhs-24thiaz-nmgly-beta34dcph
8230: ibhs-nme35pyr-bala-beta13bendi
8231: bhs-me24thiaz-gly-psdap
208232: ibhs-nme35pyr-bala-betadtrif
8233: tolhs-nme35pyr-bala-betaoxope
8234: 2py-25fur-leu-betapy
8235: tolhs-nme35pyr-bala-betahc
8236: 2py-me24thiaz-ala-psdap
258237: bim-me24thiaz-ala-betapy
8238: tolhs-25thiaz-gly-betabthioph
8239: 2py-25thioph-bala-psdap
8240: ibhs-25thiaz-gly-betahdcph
8241: bim-26py-gly-psdap
308242: 2py-35fur-gly-betapy
8243: phhs-25methiaz-bala-betabph
8244: phhs-25thiaz-bala-betahbcph
8245: ibhs-24thioph-gly-betadcphtb
8246: 2py-me25thiaz-leu-betaph
358247: ibhs-25thiaz-gly-betaipr
8248: ibhs-24thioph-gly-betacbph
8249: ibhs-25methiaz-bala-betaamibe

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NOTE: For additional valumes please contact the Canadian Patent Office.