|(12) Patent:||(11) CA 1341615|
|(21) Application Number:||617157|
|(54) English Title:||TARGETED MULTIFUNCTIONAL PROTEINS|
|(54) French Title:||PROTEINES MULTIFONCTIONS A CIBLE DEFINIE|
Disclosed are a family of synthetic proteins
having binding affinity for a preselected antigen,
and multifunctional proteins having such affinity.
The proteins are characterized by one or more
sequences of amino acids constituting a region which
behaves as a biosynthetic antibody binding site
(BABS). The sites comprise V H-V L or
V L-V H-like single chains wherein the V H and
V L-like sequences are attached by a polypeptide
linker, or individual V H or V L-like domains. The
binding domains comprise linked CDR and FR regions,
which may be derived from separate immunoglobulins.
The proteins may also include other polypeptide
sequences which function, e.g., as an enzyme, toxin,
binding site, or site for attachment to an
immobilization media or radioactive atom. Methods
are disclosed for producing the proteins, for
designing BABS having any specificity that can be
elicited by in vivo generation of antibody, for
producing analogs thereof, and for producing
multifunctional synthetic proteins which are
self-targeted by virtue of their binding site region.
|(52) Canadian Patent Classification (CPC):||
|(51) International Patent Classification (IPC):||
|(72) Inventors (Country):||
|(73) Owners (Country):||
|(71) Applicants (Country):||
|(74) Agent:||MBM INTELLECTUAL PROPERTY LAW LLP|
|(22) Filed Date:||1988-05-20|
|(30) Availability of licence:||N/A|
|(30) Language of filing:||English|
|(30) Application Priority Data:|
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|Cover Page||Cover Page||18||1|
|Representative Drawing||Representative Drawing||N/A||N/A|