Canadian Patents Database

Patent Summary

(12) Patent:	(11) CA 1341615
(21) Application Number:	617157
(54) English Title:	TARGETED MULTIFUNCTIONAL PROTEINS
(54) French Title:	PROTEINES MULTIFONCTIONS A CIBLE DEFINIE

• Abstract
• Patent Details
• View or Download Images
• View Administrative Status
• Show all claims

---

Abstracts

English Abstract

Disclosed are a family of synthetic proteins
having binding affinity for a preselected antigen,
and multifunctional proteins having such affinity.
The proteins are characterized by one or more
sequences of amino acids constituting a region which
behaves as a biosynthetic antibody binding site
(BABS). The sites comprise V H-V L or
V L-V H-like single chains wherein the V H and
V L-like sequences are attached by a polypeptide
linker, or individual V H or V L-like domains. The
binding domains comprise linked CDR and FR regions,
which may be derived from separate immunoglobulins.
The proteins may also include other polypeptide
sequences which function, e.g., as an enzyme, toxin,
binding site, or site for attachment to an
immobilization media or radioactive atom. Methods
are disclosed for producing the proteins, for
designing BABS having any specificity that can be
elicited by in vivo generation of antibody, for
producing analogs thereof, and for producing
multifunctional synthetic proteins which are
self-targeted by virtue of their binding site region.

---

Patent Details

(52) Canadian Patent Classification (CPC):	530/13 167/139 530/15 167/153 195/1.1 195/1.235 195/1.34
(51) International Patent Classification (IPC):	C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)
(72) Inventors (Country):	HUSTON, JAMES S. (United States of America) OPPERMANN, HERMAN (United States of America)
(73) Owners (Country):	MICROMET AG (Germany)
(71) Applicants (Country):	MICROMET AG (Germany)
(74) Agent:	MBM INTELLECTUAL PROPERTY LAW LLP
(45) Issued:	2011-05-24
(22) Filed Date:	1988-05-20
(30) Availability of licence:	N/A
(30) Language of filing:	English

Patent Cooperation Treaty (PCT):	No

(30) Application Priority Data:
Application No. Country Date 052,800 United States of America 1987-05-24

View or Download Images

Click on a link under View Patent Image to view a section of the image or click on a link under Download Patent Image in PDF format to download a section of the image in PDF format.

If you have any difficulty accessing content, you can call the Client Service Centre at 1-866-997-1936 or send them an e-mail at CIPO Client Service Centre.

View Patent Image	Download Patent Image in PDF Format	Size of Image (KB)	Number of Pages
Cover Page	Cover Page	18	1
Abstract	Abstract	32	1
Claims	Claims	174	6
Description	Description	2,680	70
Drawings	Drawings	1,227	50
Representative Drawing	Representative Drawing	N/A	N/A

PDF Readers.