Note: Descriptions are shown in the official language in which they were submitted.
3~1.
The present invention relates to a hair treating agent
consisting of a lotion portion and a shampoo portion, and to a
method of treating hair by applying said agent.
Loss of hair is an increasing phenomenon. While loss of
hair or alopecia up to baldness have been considered a phenomenon
typical for men and a more or less marked thinning-out of hairs
has been ascribed to women (FEY: "Worterbuch don Cosmetic",
Stuttgart, 1974, page 147), it has been ascertained in recent
times that a complete or almost complete androgenetic alopecia
occurs with women more frequently than formerly. This may be
possibly due to the taking of contraceptives. But neither hair
cosmetics nor medicine have proved effective agents against this
phenomenon (FEY foe. cit.).
Contrary to the nails on human hands and feet, which
are formed once and keep growing for a lifetime, human hair has
a limited lifetime. The resultant loss of hair is a normal
occurrence which is named hair change. The daily loss within a
range of 50 hairs is insignificant. For diverse reasons, however,
this natural loss is frequently exceeded and an unnatural loss of
hair takes place which may be due to diverse reasons. Such loss
is by no means, however, to be regarded as a pathological condo-
lion, and the treatment of this unnaturally high loss of hair
comes, therefore, under the field of cosmetics and not under that
of medicine.
The present invention provides a hair treating agent
which has proved successful in non-public experiments. Hair
treating agents in the form of a lotion portion and a shampoo
portion as a hair washing agent, the lotion portion and the shampoo
Jo ,
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portion being applied successively for a combined effect, are known.
The present invention relates to an effective agent of
said type against alopecia and for preventing callowness. The
lotion contains in an alcohol-water or low-fat base the active
ingredients horse radish juice, quintuple concentration, about 63
prim, substitutable by ally mustard oil, nettle extract prepared
in glycols, and that optionally spray-dried thymes gland extract
is added. Further additives are vitamin By, vitamin E water-
soluble (1 ml = 500 my of dl-~-tocopherol acetate), d-panthenol,
cremophore (alcohol-water-soluble castor oil) and diisopropyl
adipate. The shampoo contains alkyl-diglycol ether sulfate-
sodium, -triacethanol amine laurel sulfate, coconut fat-dimethyl
aminoxide, horse radish juice, quint. concentration, which may also
be replaced by ally mustard oil, cremophore (water-alcohol-soluble
castor oil, Spanish rosemary oil, isopropyl alcohol, citric acid
and sodium chloride.
Some of the active ingredients used have already been
used per so or in another combination without attaining the desired
effect. Thus, it has been known to apply nettle extract for both
hair lotion and shampoo (DEMOS 1 667 930 by Karl Waldmann into Of.
AWOKE, laid open on April 20, 1972; Dr. Hirsch: "Noah
Erkenntnisse don haarforschung", Chihuahuas, 1955, page 42; Curt
Humans: "Pharmazeutisches Worterbuch", Berlin, New York, 1975,
; Thea edition, page 709 sub index "Urtica-Arten"; H. Fey: "Wormer-
buck don Cosmetic", Stuttgart, 1974, page 159, bottom, sub index
"Horsier"; Karl Fries: "Mann Horsefly undo Harshened
aufgehalten warden?", Ottobrunn/Munich, 1952, page 16, bottom).
Nettle oil extract prepared for hair lotion additives is
.
' , ,
commercially available as a brown fluid soluble in water and having
a pi value of 6 - 7, under the trade name EXTRAPON (German trade-
mark 827 971 of DRAGOCO Gerderding & Co. Gob D-3450 Holzminden).
The extract is however only co-used and in combination with other
active ingredients.
Even though the mechanism of the novel hair treating
agent is not fully understood despite extensive experiments, some
basic assumptions can be made for the effect of some of its
components. The effect of the embarkation appears to reside in
the co-action of the horse radish juice in quint. concentration,
substitutable by ally mustard oil, and the nettle extract
prepared in glycols. This primarily prevents loss of hair.
The facultative addition of thymes gland extract promotes
the prevention of hair loss and leads additionally to the growth
of new hairs provided that the hair follicles are still present.
The new-growing hair is strong and in most cases newly pigmented
again, giving the hair a richer appearance.
Diisopropyl adipate together with d-panthenol and
cremophore primarily promote the penetration into the scalp to
the hair roots of the thymes gland extract. In addition, they
permit the hair to be combed more easily. Diisopropyl adlpate
Jo largely prevents possible plastering of the hair.
I; The effect of the nettle extract in glycols is a marked
reduction of setaceous secretion by setaceous glands.
The favorable effect of vitamin By, of dl-a-tocopherol
acetate and of cremophore on the hair roots is known. It has been
found that said additives essentially foment and enhance the
Jo effect of horse radish extract, of nettle extract and of thymes
- 3 -
': `' ' ' '
-
I
gland extract. Finally, citric acid serves to provide for a pHvalue of about 5.
The formation of foam and the simultaneous cleansing
effect of alkyd diglycol ether sulfate-sodium are important for
the shampoo, while triacethanol amine laurel sulfate effects a
highly significant reduction of the free fatty acids and an
increase in the triglycerides on and in the scalp, apart from its
cleansing effect. The effect is even enhanced by the presence of
horse radish concentrate, of cremophore and of Spanish rosemary
oil which displays additionally a perfume effect.
Coconut fat-dimethyl aminoxide slightly regresses the
hair, has a relaxing effect on it and makes an easy combing
possible.
It is important that the lotion portion and shampoo
portion are used together, to control or prevent loss of hair.
The growth of new hair is stimulated, the strengthening of
weakened hair is incited and fomented and new pigmenting is
initiated. To embrocate the hair twice a day with the lotion,
at best in the morning and in the evening, combined with washing
the hair with the shampoo every end or 3rd day has proved to be
the method which gives the best results.
The co-actlon of the lotion portion and shampoo portion
in the hair treating agent according to the invention and its
efficiency was supported by field work conducted by Prof. Dr.
Eva Flop of the University Hospital for Dermatology in Budapest
(cf. example l) and at the same time by Prof. Dr. med. Dr. ho
Braun-Falco, Director to the University Hospital for Dermatology
in Munich, in conjunction with the Institute fur Medizinische
- 4 -
,
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I
Informatik undo systemforschung of Munich University tcf. example
2), and by Dr. med. Georg-Peter Heilgemeir, and by the University
Hospital for dermatology in Berlin-Steglitz and its Director
Prof. Dr. Orphans. Further confirmatory work has been conducted
by eminent dermatologists in about 1800 cases. They have confirmed
the significant progress provided by the present invention in
fighting loss of hair and in fomenting new growth of hair.
Particular attention should be paid to experiments and
results by the hair status examination method (trichogramme =
examination of the hair roots), as they have been carried out by
the Munich University and the Institute fur Medizinische Informatik
undo Systemforschung, according to which the conversion from
telogenic hair (hair falling out) to anagenic hair (growing hair)
was between 8 and 30%. The normal state of 80% of anagenic hair
was found to be always achieved after treatment with the agent of
the present invention. In the 1800 cases which have been treated
up to now by the hair treatment of the present invention there
were no negative side effects (defects in the scalp or the hair).
The present invention will now be further described, by
way of example only, with reference to the accompanying drawings,
in which:
Figures lay lo and lo graphically illustrate the
frequency, by percentage, of anagenic hair roots in the front
region of the capillitium prior to treatment, after one month of
treatment, and after three weeks of treatment respectively, for
; the 46 assessable cases mentioned hereinbelow
Figures PA, 2B and 2C graphically illustrate the
frequency, by percentage, of anagenic hair roots in the occipital
- 5 -
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. : . : . :: : .
;
:~. ' ".
~Z~8Z~33L
region of the capillitium prior to treatment, after one month of
treatment, and after three weeks of -treatment respectively, for
the 46 assessable cases mentioned hereinbelow.
Figures PA, 3B and 3C graphically illustrate the
frequency, by percentage, of anagenic hair roots in the varietal
region of the capillitium prior to treatment, after one month of
treatment, and after three weeks of treatment respectively, for
the 46 assessable cases mentioned hereinbelow.
Example 1
The skin of the head was embrocated twice a day, in the
morning and in the evening, with a lotion as follows: a solution
or dispersion of 28.00 g of horse radish juice, if possible, free
; of cellulose, in quintuple concentration, about 63 prim, 34.00 g of
nettle extract prepared in glycols, is added to 6.00 g of spray-
dried thymes gland extract, 2.00 g of vitamin By, 2.00 g of vitamin
E, water-soluble (1 ml = 500 my of dl-~-tocopherol acetate), 2.00 g
of d-panthenol, 10.00 g of cremophore (alcohol-water-soluble castor
oil), 32.00 g of diisopropyl adipate in 408.00 g of isopropyl
alcohol and distilled water ad 1000.00 g, the individual substances
being admixed and introduced into the alcohol and distilled water
fraction and the resulting mixture being filtered after about 4 weeks.
This treatment was supplemented by washing the head with
a shampoo, as set forth below, every end or 3rd day. The shampoo
I; consists of a mixture of 250.00 g of alkyd diglycol ether sulfate -
sodium, 541.00 g of triacethanol amine laurel sulfate, 150.00 g of
coconut fat-dimethyl aminoxide, 8.00 g of horse radish juice, if
possible free of cellulose, in quintuple concentration, about 63
~:~
prim, 3.00 g of cremophore (water-alcohol-soluble castor oil), 9~00
Jo - 6 -
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g of Spanish rosemary oil, 8.00 g of isopropyl alcohol, 10.00 g of
citric acid, 10.00 g of sodium chloride, 20.00 g of distilled water.
When distributed uniformly on the wetted skin of the
head the measured amount of shampoo forms a rich foam which is left
on the skin of the head for 1 to 3 minutes, then it was dried after
thorough rinsing under flowing warm water. Thereafter, the skin
was repeatedly embrocated with the hair treatment. The head was
washed only once with each shampoo application.
Depending upon the rate of loss of hair, the duration of
one hair treatment varied between 4 to 6 or 8 weeks. In accordance
with the clinical state of the skin of the head in every case a
detailed hair status examination was established together with
anamnesis statements at the beginning of the treatment. Said status
described the rate of gradual thinning-out of the hair growth or of
the loss of hair, the number of hairs lost from morning till even-
in, the degree of dandruff formation and hair greasing, and further
inflammatory symptoms, itching etc.. The daily loss of hair was
counted by the test persons themselves at the beginning of the
treatment and during treatment at weekly control intervals. During
treatment, the test persons came twice a week for control checks
and upon completion of the treatment once a month, then after six
months for the registration of hair regeneration and possible
recldivisms. In the course of the above periods of time the
persons checked were not given any other similar treatment.
A total off test persons were given a cure treatment
:
with the lotion and the shampoo: 70 men and 60 women, aged from
17 to 60 years. From among these 68 men and 22 women suffered
under seborrhoic loss of hair, showing at least some baldness;
-- 7
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,
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I
in 20 cases the increased loss of hair was caused by the taking of
contraceptive tablets; 10 test persons suffered under climacteric
loss of hair, with 10 test persons there were presumably other
reasons, alopecia create, Pseudopelade Brook, gravidity for diffuse
loss of hair.
The objective and subjective side effects making them-
selves felt in the course of the treatments were recorded from
observations of each test person. Irritative and sensitizing
effects of the new preparation were examined by the lotion without
dilution: 20 persons were tested with a unique 48-hour occlusive
application on the dorsal skin and on the same surface with several
applications made 4 to 5 times in a similar mode. The examination
as to the photo toxic effect of the contents of the vegetable active
extract ingredients was carried out with 10 persons: upon a 24-
hour occlusive application by ultraviolet dose expose lion up to
below the erythema threshold. The reaction of the skin was
evaluated after 48 to 72 hours, without findings.
The objective examinations as to an inhibitory effect
I,
I; on the loss of hair were made at regular intervals, every week: I:
before the days of head washing, similar precautionary measures
being taken, and the hairs lost of from 7 hours in the morning
; up to 7 hours in the evening per day were counted.
I; The results were compared to the loss of hair correspond-
:.
in to the normal season and were evaluated by comparing them with
the number of the originally lost hairs.
Dependent on the season a daily loss of 20 to 30 hairs
of the head is considered normal. In the revaluation of the treat-
mint or of the degree of regent on "++" designated a complete
.
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I
standstill of the loss of hair or a normalization thereof. In
table l those cases in which the rate of the loss of hair was
essentially reduced as compared to the state before treatment were
designated improved by "+": to one third or at least to half the
initial value.
The type of loss of hair, the diagnostic sub-division
and the results of the joint effect of lotion and shampoo are
shown in table 1.
The table shows that from among 130 cases treated 80 test
persons, i.e. in 61.5% of the cases, displayed a complete stand-
still of the loss of hair or a normalization. In 42 cases, i.e.
32.3%, an essential improvement was achieved. In a total of 8
cases the treatment did not prove successful, i.e. 6.2% as the loss
of hair continued with heightened intensity even after a hair treat-
mint period of 6 to 8 weeks. In said cases it was found later that
the background of the loss of hair was alopecia create with 5 test
persons and Pseudopod Brook Progression with 3 test persons,
this being the reason for the treatment not proving successful. In
two cases the loss of hair occurring due to gravidity disappeared
within 4 weeks. The Ions of hair caused by diverse contraceptives
was also controlled rapidly, i.e. within a maximum of 4 to 6 weeks.
In 18 cases the loss of hair of the test persons
disappeared, in one case it was reduced to a minimum. In the case
of defluvium klimacterica the treatment proved successful, as well:
in each of the lo cases the loss of hair became gradually normal
within 4 to 6 weeks.
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With the 90 test persons treated due to seborrhoeic loss
of hair, namely 68 men and 22 women, the loss of hair came to a
standstill in So cases, i.e. 55.6~. In the remaining 40 cases,
i.e. 44.4~, the daily loss of hair was reduced by a high degree.
There was no treated case which did not show any improvement,
but a treatment of 8 weeks was necessary with 32 test persons
to achieve the desired result.
In most cases, the duration of treatment was determined
by the intensity of the loss of hair, which played also a part
in the recidivists after the cures. Table 2 shows said connect
lions.
When the daily loss of hair did not go beyond 100 head
hairs, and this was the case with 32 persons, the loss of hair
was defined to be "weak", between 100 and 200 hairs of the head,
(this was with 61 persons) it was defined to be "medium", between
200 to 300 hairs, (this was the case with 29 persons) it was
defined to be "intense" and with more than 300 hairs, (this was
the case with 8 persons) it was defined to be "very intense".
;` Very good results were achieved with the majority of patients
checked, namely with 93 out of 130, where the daily loss of hair
was less than 200 head hairs, after a cure of 4 to 6 weeks.
Among these there was even a case where the loss of hair came
to a standstill as early as the 3rd week. There were even
cases where, in addition to the disappearance of loss of hair,
even a regeneration of the hair showed, and it was only for this
very reason that treatment was continued even after the Thea week.
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Table 2 reveals also that for stopping a daily loss of
hair of more than 200 head hairs -the cure of 4 weeks did not
suffice in one case. In most of the cases treatment was carried
out for 8 weeks, e.g. in the case of a high-degree seborrhoeic
loss of hair, where dependent on the case, therapy was supplement-
Ed by giving vitamin By and Bepanthen (trade mark).
With the test persons who were treated successfully and
appeared for control, a total of 30 cases recidivists were observed.
They occurred in 10 cases within 3 months upon completion of the
cure, and in 20 cases within 6 months. The reoccurring loss of
hair with the patients, however, was always at a lower rate as
compared to the loss of hair prior to treatment, and it was possible
to bring it again to a standstill within a shorter period of time,
i.e. within a maximum of 3 to 4 weeks.
That there is a connection between intensity of loss of
hair and the readiness for recidivism is shown by the fact that
with heavy loss of hair there was recidivism in 48%, with medium
loss of hair only in 23% and with weak loss of hair none at all.
As well as the disappearance of loss of hair, another
objective improvement could be observed in the seborrhoeic cases
examined The dandruff peeling accompanied by itching disappeared
in every case, and the heightened greasiness was reduced to
normality from case to case. With the change in quantity and
quality of the head hair, regeneration of hair showed in certain
cases, as well. It was mainly in the initial state of seborrhoeic
Jo loss of hair that with 9 test persons even a few new little head
hairs were formed upon the action of the lotion and the washing
cure on the areas covered by meager head hair or Lang head hair,
- 13 -
~2,.3~
in addition on -the marginal areas of the high headline, apart
from a strengthening of the head hair already present. Simultane-
ouzel with the longitudinal growth and the reinforcement of the
individual head hairs a weak pigmentation of the Lang hairs
could be observed in some cases.
At the same time as the examinations according to example
1 were carried out, other examinations according to example 2 were
conducted.
Example 2
A hair treating agent as described below was used: The
lotion containing in an alcohol-water or low-fat base the active
ingredients as follows: one of the group consisting of horse
radish juice in quintuple concentration of about 63 prim and ally
mustard oil; nettle extract prepared in glycols; vitamin By,
vitamin E water-soluble (1 ml = 500 my dl--tocopherol acetate);
d-panthenol; cremophore (alcohol~water-soluble castor oil) and
diisopropyl adipate, spray-dried thymes gland extract also being
included. The shampoo was the same as in example 1. The thymes
gland extract used in the lotion is spray-dried powder of thymes
glands of young calves.
48 test persons, i.e. 9 women and 39 men, who suffered
from androgenetic alopecia, participated in the examinations. As
far as possible, the treatment had a duration of more than 12
weeks. During said period of time no other external or internal
hair treating agents were applied.
The hair treatment was carried out as described below:
The skin of the head was wetted thoroughly with the lotion under
slight massage twice a day, in the morning and in the evening.
- 14 -
I, :
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:
Every end to Thea day the head was washed with the hair shampoo
which was massaged slightly into the scalp and washed out
thoroughly with lukewarm water after some minutes.
before treatment, after a 4-week and after a 12-week
treatment, subjective statements made by the test persons with
respect to pains and itching in the area of the scalp as well as
on the intensity of effluviums were checked. Furthermore, before
treatment, in the course of and after treatment, objective
symptoms, such as Siberia, head dandruff and thinning-out of
hair were evaluated as to their rate, always by the same examiner.
A possibility of intensified pigmentation of the hair was also
checked.
In addition, at the beginning of the treatment, after a
4-week and a 12-week treatment the pattern of the hair root was
determined for the front, varietal and occipital region of the
capillitium.
Jo Modifying the technique according to van Scott (Scot-t,
EDGY. van:, Reinertson, RIP.:, Steinmuller, R.: The growing hair
roots of the human scalp and morphology changes there in following
amethoterin therapy, J. Invest. Dorm. 29, 197-204, 1957) according
to Braun-Falco (1. Braun-Falco, O.: Dynamic dyes Norma Len and
pathologischen Haarwachstums. Arch. kiln. exp. Dorm. 227, 419-452,
1966, 2. Braun-Falco,- O.: Fischer, Oh.: User den Einflu~ dyes
Harshness auf day Haarwurzelmuster. Arch. kiln. exp. Dorm.
226, 136-143, 1966, 3. Braun-Falco, O.:, Rezoner, B.: User den
Jo Einflu~ don Epllationstechnik auf morale undo pathologische
Haarwurzelmuster. Arch. kiln, exp. Dorm. 223, 501-508, 1965, I.
Braun-Falco, O.:, Zion, H.: Sum Wizen don chronischen Alps bet
- 15 -
.
I` '
I: , '. ', :
38~
Frown. Arch. kiln. exp. Dorm. 215, 165-180, 1962), a tuft of
50 to 70 hairs was synchronously depilated by rapid drawing and
in parallel to the direction of the hair. A special depilation
clamp is used for this purpose. To avoid shrinkage proceedings
at the hair roots the hairs are introduced immediately after
depilation into a Putter dish containing a wetted cotton ball, thus
serving as a moistened chamber. Preparation of the material
recovered was effected as soon as possible. The proximal proper-
lion of the hair shaft carrying the hair roots was embedded
between two object supports in a physiological common salt
solution, the distal proportion being rejected. The individual
hair roots were differentiated into their diverse forms by a
binocular microscope at a coefficient of magnification of 31.
Upon registration of the absolute figures, a calculation was made,
in percentage, of the forms of hair roots, of the truckers-
Grimm or the hair root status, rest.. As regards the different
features of the individual forms of hair roots, reference was
made to the literature cited in the foregoing. In the present
study the following forms of hair roots were registered: anagenic,
telogenic, dystrophical and pseudodystrophical hairs.
When carrying out the experiments particular care was
taken to keeping the required period of time of 7 days between
the last hair washing and the depilation of hairs. Unfortunately,
this was not ascertained in all of the cases. Assuming that an
increase in pseudodystrophical hairs was either a consequence of
the last washing of hair or of too slow an depilation, in all
- examinations the proportion of pseudodystrophical hair roots was
interpreted as anagenic hair roots.
- 16 -
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:
In the course of the treatment with the agent according
to present application the growth of hair should have been improved,
which would be given expression to in the pattern of hair roots by
an increase in anagenic hairs. At the same time the proportion of
telogenic hairs would logically be reduced, as in the present cases
the proportion of dystrophical hairs each is close to 0%. The
hairy scalp material observed is recovered: from three areas
front, varietal and occipital. Only one treatment group was
referred to and the indication as to efficiency was sought only
by the historical comparison (prior to as against afterwards by
3 measured items: beginning, 1 month, 3 months) as well as
knowledge of the normal situation (proportion of anagenic hair
about 80%).
A total of 46 assessable cases were taken for statistical
evaluation. From among these, only 16 cases had data available
on all three points of time, and only 25 cases on the two first
points of time.
Figures 1 ("front"), 2 ("occipital") and 3 ("varietal")
show the results - given by the Institute fur Medizinische
Informatik undo Systemforschung don GSF Neuherberg, Prof. Dr. med.
W. van Eimeren undo M. Sun, U.S. in accordance with the examine-
lions made by Prof. Braun-Falco- of the examinations of hair roots
in the front, varietal and occipital region of the capillitium,
each subdivided according to frequency prior to (fig. "A" each)
treatment, after one month of treatment (fig. "I" each) and after
three weeks of treatment (fig. "C" each). ire, the distribution
of anagenic hair in percentage is shown throughout the duration
of treatment, divided in accordance with points of observation on
17 -
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3l3~8~
the scalp (front, varietal and occipital). The illustrations
do not only distinctly show the high proportion of cases of
almost normal percentages, but also the high loss of cases in
the course of the examination procedure.
Prior to treatment with the agent, 12 test persons
showed heavy, 6 moderate and 4 weak Siberia of the capillitium.
The degree of heaviness of Siberia, which was always judged
clinically by the same examiner, was high with 4, moderate with 8
and weak with 8 test persons after an application of 4 weeks.
After 12 weeks Siberia was judged to be heavy and moderate each
with 4 test persons and weak with 6 test persons. From among the
test persons treated 6 had intensive, 6 moderate and 2 weak
dandruff of the heads in the sense of a pityriasis simplex
couplet. After a treatment of 4 weeks, 3 test persons each
had an intensive and moderate formation of dandruff and 5 test
persons a weak one. After a 12-week treatment there was in none
ox the cases an intensive dandruff, with 5 test persons each,
however, moderate and weak dandruff.
To assess the degree of intensity of thinning-out of
hair the sub-division of androgenetic alopecia according to
Hamilton (Hamilton, JOB.: Patterned loss of hair in man: types
and incidence, Ann. of the New York Academy of Sciences 53, 708,
1951; Heilgemeir, GYP.: User den Aussagewert don Haarwurzelstatus-
method, Inaug. Dissent. Munches 1975) was used. Among the test
persons treated with the agent there was 17 times type of duster
` button II, 13 times type of distribution IV, 4 limes type of
distribution V and twice type of distribution VI, and once type
of distribution VII. With 9 test persons there was the typical
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. .. , . . .
:
:~38~
female pattern of distribution of androgenetic alopecia (female
type). Throughout the whole period of observation of three months,
in none of the test persons was there any change in the pattern of
distribution of thinning-out of hair.
In one of the test persons a striking re-pigmentation of
vellum hair within the heavily thinned-out varietal region was
found in the course of the 12-week treatment. On the basis of the
examinations made it cannot be said conclusively to what extent
a re-pigmentation or an erogenic modification of the hair shaft
is due to the agent applied for.
No serious side effects were found out during the
treatment with the agent applied for. One test person broke off
the treatment after a three-week treatment owing to subjective
deterioration of loss of hair, another person after weeks owing
to burning on the skin of the head. In both cases the complaints
could not be verified objectively during the clinical control
examination. As for other cases, neither cosmetically disturbing,
nor irritating effects due to the agent applied for could be
observed within the region of the hairy head skin throughout the
whole period of observation.
With I test persons having androgenetic alopecia, from
among these 39 men and 9 women, the effect of a therapy of up to
12 weeks with the agent of the invention was examined as to
growth of hair. were, an improvement of subjective symptoms such
as pains within the area of the scalp and itching of the hairy
I; skin of the head was determined according to statements made by
Jo the test persons. According to subjective statements of the test
persons treated there was also a lessening of the intensity of
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: 'I
:~38~
effluviums and it may be emphasized in this conjunction that the
test persons were almost unanimously content with the effect of
the agent according to the application.
Taking into account the dynamics of hair growth an
increase in capacity of hair growth owing to an agent for foment-
in hair growth could be brought about as follows: on the one
hand by an artificial prolongation of the anagenic phase at the
expense of the duration of the telogenic phase within Gone hair
cycle, on the other hand by a premature termination of the tell-
genie phase with the introduction of the hair follicle. The consequence would be an increase in the proportion - in percent-
age - of anagenic hairs at the expense of telogenic hairs in the
pattern of hair roots.
Said effect of the hair treating agent on the percentage
of anagenic hairs, which becomes apparent in the examinations
submitted in the sense of a positive influence on the growth of
hair in the case of androgenetic alopecia within the course of a
three-month period of treatment is, however, still in need of
further examinations and statistical backing.
: .
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