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Patent 2070879 Summary

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(12) Patent Application: (11) CA 2070879
(54) English Title: GAMMA CAMERA IMAGES HAVING REDUCED ARTIFACTS
(54) French Title: IMAGES DE GAMMA-CAMERA A REDUCTION DES ARTIFACTS
Status: Dead
Bibliographic Data
(51) International Patent Classification (IPC):
  • G03B 42/00 (2006.01)
  • G01T 1/164 (2006.01)
  • G06F 17/00 (2006.01)
(72) Inventors :
  • BERLAD, GIDEON (Israel)
  • MAOR, DOV (Israel)
  • SHREM, YIGAL (Israel)
  • SOIL, ADRIAN (Israel)
(73) Owners :
  • GE MEDICAL SYSTEMS ISRAEL LTD. (Israel)
(71) Applicants :
(74) Agent: SMART & BIGGAR
(74) Associate agent:
(45) Issued:
(22) Filed Date: 1992-06-09
(41) Open to Public Inspection: 1992-12-10
Availability of licence: N/A
(25) Language of filing: English

Patent Cooperation Treaty (PCT): No

(30) Application Priority Data:
Application No. Country/Territory Date
098420 Israel 1991-06-09

Abstracts

English Abstract



P495



Abstract of the Disclosure

A system for recording fewer of the events that are caused either
by Compton scatter photons or by gamma radiation interacting with
lead. The system locally determines the energy spectrum and fits
the determined energy spectrum with a trial function composed of a
photopeak component of known energy shape, but unknown magnitude
and a Compton scatter component having a theoretically derived
energy shape and an unknown magnitude for each pixel of the image.
The trial function is locally fitted to the measured energy
spectrum to obtain the values of both the Compton Coefficient and
the gamma radiation interacting with lead. This enables removal of
Compton contamination and also the contamination caused by
interaction of the gamma photons with lead components.


Claims

Note: Claims are shown in the official language in which they were submitted.


- 28 -
P495



What is claimed is:



1. A method of improving images from a gamma camera system by
considering isotopes having k photopeaks and by reducing the
contribution of unwanted photons on an image produced by a gamma
ray imaging system, said method including the steps of:



detecting photons impinging on a gamma ray detector in an X,Y
coordinate location according to the location of the impingement
on the detector.



determining the energy of each detected photon,



grouping each detected photon according to the determined energy
in the X, Y coordinate location,



accumulating counts of said grouped photons according to the
determined energy level of the photons at each X, Y coordinate
location,



constructing an energy spectrum of each X, Y location using the
accumulated counts,



determining an energy distribution of unwanted photons,

- 29 -
P495



determining the energy spread function of the gamma camera system
for the known energy of the wanted photon and for the determined
energies of the unwanted photons,



using the determined energy distribution of unwanted photons and
the energy spread function of the system to obtain a system
dependent energy distribution of the unwanted photons per X,Y
coordinate location,



constructing a trial function comprising the system energy spread
function multiplied by an unknown coefficient of wanted photons
plus the system dependent energy distribution of unwanted photons
multiplied by unknown coefficients of unwanted photons,



locally fitting, the trial function to the constructed energy
spectrum to obtain the count of the wanted photons by solving for
the unknown coefficient of the wanted photons, and



using the count of the wanted photons to produce an image
practically free of unwanted photons.




2. The method of improving images from gamma camera systems of
Claim 1 wherein unwanted photons include Compton scattered
photons.


- 30 -
P495



3. The method of improving images from gamma camera systems of
Claim 2 wherein said unwanted photons include other unwanted
photons.



4. The method of Claim 2 wherein said unwanted photons include
lead X-ray photons.



5. The method of Claim 3 wherein k=1.



6. The method of Claim 3 wherein k>1.



7. The method of Claim 1 wherein the step used to obtain the
system dependent energy distribution of unwanted photons includes
the step of calculating the energy distribution of unwanted
photons for each value of k.



8. The method of Claim 7 wherein the step of using the
determined energy distribution of unwanted photons and the energy
spread function of the gamma ray imaging system includes
convolving the energy distribution of unwanted photons with the
energy spread function of the gamma ray imaging system.



9. The method of Claim 7 wherein the step of using the
determined energy distribution of unwanted photons and the energy
spread function of the system includes the step of measuring at
least one energy distribution of unwanted photons with the system


- 31 -
P495



whereby the measured distribution inherently includes the energy
spread function of the system.



10. The method of Claim 8 wherein said step of constructing a
trial function comprises:



summing the convolved system dependent energy distribution of the
determined energy distribution of unwanted photons including the
system energy distribution of Compton scattered photons and
additional unwanted photons both with unknown X,Y coefficients,
and



locally fitting the trial function to the constructed energy
spectrum to solve for the unknown X,Y coefficients and thus for
determining the counts of the unscattered photons.



11. The method of Claim 10 wherein said step of determining the
energy distribution of unwanted photons comprises the step of:


analytically determining the energy distribution of Compton
scattered photons.



12. The method of Claim 11 wherein the step of analytically
determining the energy distribution of Compton scattered photons
includes the steps of:


- 32 -
P495



converting a Nishina-Klein equation to an m order photon scatter
probability distribution to determine the energy distribution of
the m order scattered photons where m=1,2...M, and



convolving the energy distribution of the m-order scatter photons
with the energy spread function of the system to obtain
probability distributions of m+1 order scatter photons.



13. The method of Claim 12 including the step of obtaining a set
of discrete functions from the energy distribution of the m-order
Compton scatter photons by averaging the calculated Compton energy
distributions for each grouping.



14. The method of Claim 13, including the step of reducing the
number of calculations.



15. The method of Claim 14 wherein the step of reducing the
number of calculations comprises converting discrete functions
into an orthonormal set of functions.




16. The method of Claim 15 wherein the fitting step includes:



using quasi-local pixels to obtain local counts of the scattered
photons, and


- 33 -
P495



doing a single parameter fit to determine the local counts at each
of the k photopeaks.



17. The method of Claim 16 wherein the step of using quasi-local
pixels comprises:



using large pixels comprising a (2n +l)X(2m +1) rectangle of
pixels where both n and m are positive integers and the value of
the large pixel is divided by the number of pixels in the large
pixel and attributed to the center pixel, and



evaluating all pixels in this method.


18. The method of Claim 1 wherein the step of locally fitting the
trial function to the constructed energy spectrum is accomplished
using a maximum likelihood fit.



19. The method of Claim 1 wherein the step of locally fitting the
trial function to the constructed energy spectrum is accomplished
using a partial maximum likelihood fit.


- 34 -
P495



20. The method of Claim 1 wherein the step of locally fitting the
trial function to the constructed energy spectrum is accomplished
using a combined least square and maximum likelihood fit.



21. A method of producing practically unwanted photon free images
of a patient with a gamma ray imaging system, said method
comprising the steps of:



determining a trial function,



said step of determining a trial function comprising the steps
of:



multiplying a known system energy spread function by an unknown
count number due to unscattered photons,



convolving an energy distribution of m-order scatter photons
derived from the probability of physical interaction of the
photons in the known system and a system energy spread function to
provide a system dependent set of Compton fit functions,



multiplying the system dependent Compton fit functions by unknown
numbers corresponding to counts of scattered photons,



locally measuring an energy spectrum of the patient that includes
total counts due to wanted photons from k energy lines in a radio


- 35 -
P495



isotope ingested by the patient, where k=1, and due to unwanted
photons including scattered and additional unwanted photons,



locally fitting the trial function to the locally measured energy
spectrum to determine the unknown count due to unscattered
photons, and



using the count number due to the unscattered photons to produce
the practically Compton free image.



22. The method of Claim 20 wherein the step of measuring the
energy function includes the steps of:



determining an X,Y location and energy of photons impinging on a
system photon detector,



using a plurality of matrices having X,Y pixels corresponding to
impinging locations to accumulate counts of impinging photons,

each of said matrices corresponding to one of a plurality of
energy windows spanning an energy range, and



constructing the measured energy spectrum from the accumulated
counts in the matrices.



23 A system for improving images from a gamma camera system by
considering isotopes having k photopeaks and by reducing the

- 36 -
P495



contribution of unwanted photons on an image produced by a gamma
ray imaging system, said system comprising:



a gamma camera detector for detecting gamma photons impinging
thereon at an X,Y coordinate location,



means for determining the energy of each detected photon,



means for grouping each detected photon according to the
determined energy in the X, Y coordinate location,



means for accumulating counts of said grouped photons according to
the determined energy level of the photons at each X, Y coordinate
location,

means for constructing an energy spectrum of each X, Y location
using the accumulated counts,




means for determining an energy distribution of unwanted photons,



means for determining the energy spread function of the gamma
camera system for the known energy of the wanted photon and for
the determined energies of the unwanted photons,



means for using the determined energy distribution of unwanted
photons and the energy spread function of the system to obtain a


- 37 -
P495



system dependent energy distribution of the unwanted photons per
X,Y coordinate location,



means for constructing a trial function comprising the system
energy spread function multiplied by an unknown coefficient of
wanted photons plus the system dependent energy distribution of
unwanted photons multiplied by unknown coefficients of unwanted
photons,



means for locally fitting the trial function to the constructed
energy spectrum to obtain the count of the wanted photons by
solving for the unknown coefficient of the wanted photons, and



means for using the count of the wanted photons to produce an
image practically free of unwanted photons.



24. The system for improving images from gamma camera systems of
Claim 23 wherein unwanted photons include Compton scattered
photons.




25, The system for improving images from gamma camera systems of
Claim 24 wherein said unwanted photons include other unwanted
photons.



26. The system of Claim 24 wherein said unwanted photons include
lead X-ray photons.


- 38 -
P495

27 The system of Claim 25 wherein k=1.

28. The system of Claim 25 wherein k>1.



29. The system of Claim 23 wherein the means to obtain the
system dependent energy distribution of unwanted photons includes
means for of calculating the energy distribution of unwanted
photons for each value of k.



30. The system of Claim 29 wherein the means for using the
determined energy distribution of unwanted photons and the energy
spread function of the gamma ray imaging system includes means for
convolving the energy distribution of unwanted photons with the
energy spread function of the gamma ray imaging system.



31. The system of Claim 30 wherein the means for using the
determined energy distribution of unwanted photons and the energy
spread function of the system includes means for measuring at
least one energy distribution of unwanted photons with the system
whereby the measured distribution inherently includes the energy

spread function of the system.



32. The system of Claim 30 wherein said means for constructing a
trial function comprises:


- 39 -
P495



means for summing the convolved system dependent energy
distribution of the determined energy distribution of unwanted
photons including the system energy distribution of Compton
scattered photons and additional unwanted photons both with
unknown X,Y coefficients, and



means for locally fitting the trial function to the constructed
energy spectrum to solve for the unknown X,Y coefficients and thus
for determining the counts of the unscattered photons.



33. The system of Claim 32 wherein said means for determining the
energy distribution of unwanted photons comprises:

means for analytically determining the energy distribution of
Compton scattered photons.


34. The system of Claim 33 wherein the means for analytically
determining the energy distribution of Compton scattered photons
includes:




means for converting a Nishina-Klein equation to an m order photon
scatter probability distribution to determine the energy
distribution of the m order scattered photons where m=1,2...M,
and


- 40-
P495



means for convolving the energy distribution of the m-order
scatter photons with the energy spread function of the system to
obtain probability distributions of m+1 order scatter photons.

The system of Claim 34 including means for obtaining a set of
discrete functions from the energy distribution of the m-order
Compton scatter photons and means for averaging the calculated
Compton energy distributions for each grouping.



36. The system of Claim 35, including means for reducing the
number of calculations.



37. The system of Claim 36 wherein the means for reducing the
number of calculations comprises means for converting discrete
functions into an orthonormal set of functions.



38. The system of Claim 36 wherein the means for fitting
includes:

quasi-local pixel means for obtaining local counts of the
scattered photons, and


means for doing a single parameter fit to determine the local
counts at each of the k photopeaks.


P495

-41-

39. The system of Claim 38 wherein the quasi-local pixel means
comprises:


large pixels comprising a (2n +1)X(2m +1) rectangle of pixels
where both n and m are positive integers and the value of the
large pixel is divided by the number of pixels in the large pixel
and attributed to the center pixel, and

means for evaluating all pixels in this method.


40. The method of Claim 1 wherein the step of locally fitting the
trial function to the constructed energy spectrum is accomplished
using least square fitting.


Description

Note: Descriptions are shown in the official language in which they were submitted.


P~95 ~7~7~

Field of th Q _Ivention



This invention is concerned with gamma camera imaging and, more
particularly, with methods and systems for obtaining images having
reduced artifacls du~ -to multiple photopeak and unwanted events.
An event is herein defined as a pho-ton strikins. the gamma camera
detector and causing a scintillation that is ac~luired as data for
use in constructing an image. This is an improvement to the
invention entitled "Compton-Free Gamma Camera lmages" filed in
Israel on June 11, ~990, and which received ~erial No. 094691.



Back~round of_tle Invention



In passin~ thro-lgh the human body, gamma pholons have a certain
probability o~ scattering due to the Compl-~n effect. Such
scattering changes the direc-tion and energy o~ e photons. When a
photon that has been scattered is detect:ed by Ihe gamma camera,
false position informa-tion is derived from the ~.ca-ttered photons.
Thus, the scattered pho-tons cause events tha-t a-e unwarl-ted for use
in cons-tructing the ima~e. ~lther unwantecl ~vents exist. For
example, the radiation emitted from -the patient -ften excites lead
(K~ X-rays from the collimator and other lead narts. These X-rays
also impinge on the detector and may be regi!-lered as events.
These X-ray photons constitute an additionill source of image
blurrin~.


-~ 2 ~
P495



The problem Or X-I ay induce(i ~v~nts arises esr~ ially for radio
isotopes emitting photons in the energy rang~ of ~8-1~0 KEV. In
-this range, tlle lead X-ray e~cita-t;orl probabilil-~ is high and the
spectrum of these photons coincides with a relevant part of -the
isotopes spec-trum, by partially o~erlapping the pho-topeak. Thus,
the unwanted part of the spectruln in each pixel has two terms: one
made up of -the Conlp-ton scatterecl phol:ons, and t~ other made up of
the lead X-ray photons.



In principle the events caused by unwan-ted photons should be
discarded. Howeve.r, it is not easy to arrive at ,~.riteria that are
e.fficient ancl efEective for discarding such events. For example,
an energy level criterion i5 not efEective because although the
photon loses par-t of its ellergy in the scatlering process, the
energy resolulion of the -typical .gamllla camera jr such that there
is a large amount o~ overlap betueen the energ~ oE unscatterecl and
scattered photons.



The invention of the previously mentioned ~-atent application
provided methods and means ~o~ qualitativel~ and quantitatively
improving the recorded images by signiEica~ ly reducing the
contribution of Compton scattered photons to the final image to
thereby provicling a practically Comp-ton-free .image within seconds
after acquisiticn. The invention accomplishes ~he task oE reducing

the number of` events caused by Compton scaltered photons by
locally determining the energy spectrum and fi-tling -the determined


2 ~ 7 ~
P495



energy spectrum wi-th a "trial" function comr~3sed of a photopeak
component of known energy shape but unknown magnitude and a
Compton scatter component having a theore~ically derived energy
shape and an unknown magnitude for each pixel o[ -the image.



The true physical charac-teris-tics of the Comp-ton process are used
in the previously mentioned Patent Applicatiol)-to derive Compton
multi-sca-tter functions which are subsequently llsed -to cons-truct
the Compton sca-tter component energy spectra. Ihus, the previous
Patent Application uses the following inputs to determine the
unknowns; (i.e., the magnjtude of -the photopeak component and the
magni-tude of -the Gompton multi-scat-ter componenl:s):



1. -the measured energy spectrum E)er piY~I. This includes
counts due -to sca-tterecl and unscattere-:l pho-tons, and



the measured system energy spread function for -the
isoto~3e centerline which provide the photopeak energy
shape.




The shape of -the ~ompton Gomponent of tl~ trial function is
analytically derived in the prior application hy conver-ting the
Nishina-Klein Eguation that describes -the physical relativistic
scattering of photons wi-th electrons int-o a probability
distribution for a photon to scat-ter from a given energy -to a
lower energy in a single in-teraction with an electron. Repeated


r; ~ $

P495



convolutions arc llsed to obtai~l Ihe probabil.it:y distribution for
the higher order scatter terms.



By locally fit-ting -the -trial function to t.he measured energy
spectrum of acquired data the values of the multi-scattered
Compton co-ef~i.cients and the ~hotopeak magnilllde were obtalned.
This enables the removal of Compton contalllination from the
acquired data.



The prior invention however assumed a single photopeak. In
certain isotopes -there is more than one photopeak. If a single
peak is assumed when more -than one pealc a~ ually exists the
removal of scat-tered events ftom -the image will t!e incomplete.



Accordingly the invention of this Applica-tion is an improvement
over the invention of -the pri.or mentioned ~pl~lications in tha-t
among other -thin~s it takes in-to account radi(~ isotopes having
more than one peak and also takes in-to account all unwanted events
due to Compton sca~tered photons and photons de~rived from such
phenomena as X-rays caused t~y gamma radiatioll interacting with
lead components.


P495
~7~
Brief De~ t.ion_of the Inverltioll



The present invention represents an improvement over -the inventi.on
oE -the Israel Paten-t Application, Serial No. 09~1691. The present
invention reduces events caused by unwanted pho-t:ons including, but
not limited to, Compton scat-ter photons and also -takes in-to
account multiple photopeaks, such as are )I>tained when using
certain radio isotopes. Thus, -the image provided by utilization of
the present invention improves over -the image o~ the invention of
the prior mentioned Patent Application.



In accordance with the present invention, thele is provided a
method of reducing the contribution of unwanted photons to an
image produced by a gamma ray imaging system, said method
including the s-teps of:



detecting photons impinging on a ga.mma ray detector as event
counts,



measuring the energy of said ;mpingin~ phot-~rls and an X, Y
location for each photon according to the location of the
impingement of the photons on the detector,




grouping each detected photon according to the measured energy and
the X, Y location,


P495



accumulating counts of said ~hotons at ea~ X, Y location
according to the determined energy level of the photons,



constructing a rneasured energy spectrum a-t each X, Y location
using the accumulated counts oE -the determined erlergy levels, said
measured energy spectrum including counts oE wanted and unwanted
photons,



calculating the energy distributions of unwanted photons,



determining the energy spread ~unction of the f~amma ray imaging
system bein~ used,
.
o~taining a sys-tem dependent energy distribution of the unwanted
photons per location by using the energy distribution of the
unwanted photons and the energy spread function of the system,



constructin~ a trial function compri~ing -the system dependent
energy spread function mult;p];e~l by an unkno~1n coefficient of
wanted photons plLIs unknown ,-oeflicients ol: unwanted photons
convolved with the system's energy spread function.




solving Eor the unknown coeff.icient of the wanted photons by
locally fitting the measured energy distrihlltion to the trial
energy distribution of photons, and


P495 ~ 7 ~

using the cOIJnt of -the wanted pi~otons -to produce an image
prac-tically free of unwanted photons.



According to a feature of the inverltion, the unwanted photons
include Gompton scattered photons origina-ting from single or
mul-tiple radio iso-tope photopeaks.



According -to another feature of the invention, the unwanted
photons further include photons such as those due to lead X-rays.



Brief ~escript on of the ~ a in~s



The a~ove men-tioned obiec-ts and features of the present invention
along with addi-tional obiec-ts and ~eatu.res will be best understood
when considered in -the light of the following description made in
con~unction wi~.h t}-~e accompanying clrawings; wherein:



Fig. 1 is a block diagram showing of a gamma radiation imaging
system for providing improved images by elimir)ating blurs caused
in the pas-t by multiple pho-topeak isotopes and Ihe inclusion of
unwanted even-ts genera-ted by Comp-ton scattered photons and other

unwanted photons, and



Fig. 2 represents details of the preparatiorls, compu-tations and
operations used in the system shown in Fig. 1.




.

P4~5 ~7~

General Descri~tion



Fig. 1 at 11 generally shows in block diagram form the inventive
gamma camer~a system for producing improve-l images. Fig.
comprises a measured energy spectrum s-tage 12, a -trial function
preparation stage 14 and a curve fi-tting or compu-tation stage 15
which provides an unwanted pho-ton-Eree image (~ I) 16.



The measured energy spectrum stage 12 comprises a gamma radiation
detector 17. The gamma radiation de-tector 17 provides electrical
signals responsive to events; i.e., photons imp;nging on the Eac.e
thereof, such as indicated a-t 1~. When an event occurs, electrical
signals are provided on conductors 19, 21 and 22. These conductors
19, 21 and 22 are directed immediately -t:o a coordinate computer 23
which determines X and Y loca-tion of tlle impingelllent of the pho-ton
18 onto the detector 17.



Conductors 22 and ~4 carry an electrical rel!resentation of the
energy oE the photon. The electrlcal represerlt~tion of the energy
is provided to an energy (Z) correction Cil~CUit ~5. An energy
processing circuit 26 divides -the range of energy de-tected into a
number of energy windows prede-termined by the s~stem operator.




When the energy is within certain limits, the energy correction
circuit sends an enable signal over conductor ~ which enables the
coordinate computer to determine the X and Y coordinate location~


- 10 -
~7~
P495



of the event. This informa-tion is direc-ted -to an image corrector
and digitizer circuit 31 which correc-ts and digi-tizes the X Y
coordinates of the event. The information on tlle number o~ events
is placed into a plurality of matrices ~2 clependent on the
photon s energy. Each of the matrices is a memory that retains the
counts of even-ts per X Y location for a partic~llar energy window
such as for example a window tha-t extends frolll 22 KEV to 25 KEV
for window No. 1 and ~5 KEV to ~8 KEV for window No. 2 etc. The
windows are shown as W1 W.2 W3 e~tending -to Wn where n is the
predetermined number of energy windows.



The matrices are thus divided into X Y locations that correspond
to the co-ordinate loca-tion of the event on the cle-tector. The X Y
locations also correspond to pixels in the final image. An imaging
preprocessor 33 receives the clata pixel-by-pixe.l from each of -the
winclows and computes a measured or an acquired energy spectru~ N~
per pixel as shown in block 34. This acquiled energy spectrum
includes both the counts due to unwanted photons and wanted
pho-tons. The unwanted photons include Compton scat-ter photons and
other or additional unwanted photons. No-te -tha-t the energy
spectrum may include more than one energy peal~ as shown in block
34.



The trial function s-tage 14 of Fig. 1 prepares a -theoretical or a

trial energy distribu-tion n(X Y ~) including wanted and unwanted
events herein:


P495



~(XlY~)=Np(X~Y)~ m (x~y)Jd~F~ )~m(~ ~(X ~Y) R(~) (1)
m=1
here:


~ = E/m~C2 the photon ener~y in units of electron rest energy,
m~C~,


u)
P(~)=,EWlP(~ ); it is -the sys-tem energy spread Eunction at
~ 2...; (P(~) can also be measured in an envil~onment free of all
unwanted photons).



(k) is a superscript denoting the number of discrete energy lines
in the source,
m is a subscript indicating -the numbe:r of the C.ompton scat-ter
order, and
M is a script indicating the chQsen number of Compton scatter
orders included in the computa-tion.




~m(~ ) iS -the energy distri~ution of events caused by photons
scattered m times from original energies ~ ith known relative
intensities W~ to intermediate energy ~' (i.e., the shape of the

energy probability distribution of pho-tons scattered m times),



~m(~ Wl~ ) with ~[~, for m~ being calculated
recursively,




' :

- 12 - 2B7~7a~
P~95




W1 are the known relative intensities of ~ Wi=1.



N~tX,Y) is the spa-tial distribu-tion (counts/pixel) of events
caused by unscattered photons.



Qn.rX,Y) is the spatial dis-tribution (counts/pixel) of events
caused by photons scattered m times,



is the original energies of the pho-tons emitted from a
radioactive source,



is -the measured energy of the photon,



~' is an intermediate energy of a photoll,




R(~) is the measured energy spectrum of aclditional unwanted
photons such as by way of example photons from lead X-rays. tNote
R(~) can also be calculated using published tables and convolvi.ng
with -the system spread function).



Ko(X~Y) is the spatial distribution tcounts/pixel) of the events
caused by the addi-tonal unwanted radiation.



~n important purpose of the invention is -to determine the spatial
distribution of the wanted events N~ (X, Y).


-- ~ ~ 7 ~ 3 1
Y~i95



To determi.ne -tlle coun-t of events per pixel, block 15 fits the
measured value6 that i8 the measurecl energy spectrum per pixel and
the system energy spread function with unknowns; i.e., the
magnitude of the photopeaks and the shape and magnitude of the
unwan-ted photon spectrum -to the values of the trial distribution
n(X,Y,~). 'rlle fit provides the wanl:ed spa-tial dis-tribution N~ (X,
Y). With the knowledgè of the spatial distribution of the wanted
photon, the scattered and other unwan-ted photon-free image is
pr~cluced as indicated at 1~.



Details of the computations that oscur a-t -the trial function
preparation sectiorl 14 of Fig. 1 are inclicated ln Fig. ~. More
particularly, as shown in l~ig. 2, values based on the system
energy spread Eunction shown in block ~,1 of Fig. 1 and Fig. 2, are
entered into bloclcs 36 Figs. 1 and 2. In addition, values based on
acldlti.onal unwanted (photons) racliation such as, for example, lead
X~rays are determined (either by measurement or by compu-tation) as
6hown in block 40 oE Figs. 1 and 2.



The energy spread function of the system i6 a.~.sumed to be known.
It is measured once and ls kep-t in -the memory of -the sy~tem. The
measurement is easily accomplished by providin~ sources of gamma
radia-tion oE known energy and detecting the racliation with -the
equipmen-t 11 oE Fig. 1, for example. The de-tecl:ion is made without

any Compton scatter media or X-ray providing lead between the
energy 50urce and the detector. This provides an energy spread



P495



function for a monoenergy source or a multi-energy force due to
the detector energy resolution without unwanted photons as shown
in block 41. The preparation block 36 comE~u-tes ~m i.e., the
energy distribution of the unwanted photons including Compton
photons, for example, and further including Compton photons for
eac.h scattering order. This is done by using the Nishina-Klein
equation to derive -the differen-t orders of scat-tered unpolarised
photons; i.e.:



-~-rl (c~ t ~

; elsewhere



~ ) is the weighted com~ination of the fil~st order Comp-ton
energy distribution for each oE tt-e k photopeaks, or


~t~ W~ a)
i=l

The higher orders of sca-tters are derived recursively by repeated
convolution usin~ the equa-tion:


,,~ 6~ (3 ~


~ ~ ; elsewhere



Where ~ is the maximum of all ~ ... k).

- 15 -
P495



Note that -the equations are solved recursivel~ in that each hi~her
order equation requires knowledge oE the lower prior orders.



The energy distribution of Compton scatter photons provide a curve
independent of the system for each order of the scatter. However,
-this system independent curve is acted upon by the system energy
spread function to provide -the system clependent Compton
multi-scattered energy distributions denoted by ~m(~). The
shapes of the C~ ) dis-tributions are obtained by convolving
~m with the system ~nergy spread function P(~ ); i.e.:



(k) ~ (k)
C~ (~)=) d~'~m (~')P(~ ) (4)


This set of equations provides the shape of the Compton energy
distributions for each order of scatter af-ter bein~ operated on by
the system energy spread function.



Fig. 2 indicates the computations resulting in the ~m values using
the Nishina-Klein equa-tion in blocks 42, 4~ and 44 for ~. and


~)
consequently ~2 . . . m.



The shapes of ~kl ~2 and ~ in blocks 42, 43 and 44 are shown as
being convolvecl with the sys-tem energy spread furlction of block 41
in blocks 46, 47 and 48 respectively, thereby providing the shapes
C1~ C2, etc . The computations to determine ~ 2, e-tc., are


- 16 -
P495 2~7~

indicated as being recursive by the arrows going from ~ to ~2,
etc.



Hereafter the superscript (k) denoting the number of discrete
energy lines in the source is omit-ted from the Cs.



A method for drastically reducing the number of computations is
useful in this system. The reduction in the number of computations
is accomplished by orthonormalization of the se-t Cm(~). The
orthonormiaization is provided by constructing an orthonormal
function (vector) set ~ using the Graham-Schmidt procedure:



~, = Cl/ J~C12>

(~2 = ( C2 ~ C2 > ~ < C2~2 > - < ~ l ~ C2 > 2

~) M ¦ ~ M ~
= (C - E ~C >~D/I<c - ~<~- C ~2 (5)
M-~1 M+l ~=1 M+1 ~ Y M+1 ~ =1 M-~1


Where for convenlenc,e C~ ) is defined as being identical to

R(~).




Where sums (integrals) over energy are defined by:



E F(E) - ~F~
E

P~.95

Note that -the array set C~} obeys:

(~,i=j
< ~ = ~ ~ J
o,i=i .

The or-thonormalization is accomplished in computer 49 and the
results; i.e., ~ 2.. .~m-~l are shown in blocks 51, 52 53, for
example.

The Compton sum (EQ(4)) can be rewritten using the ~k'S:

QmCn~ = ~ am~ < Cm~31c ~.~)1': ( )

E t ~ < Gm ~ ~)k > Qm ) ~ ~)k ( 6 )

=~ qle ~ ~k

where:
.
q~ < Cm ~)k > am
and: m = 1,2...M+1
k = 1,2...M+1.


*[with an orthonormal base ~"~} any vector v can be represented
as a superposition of an array oE ~m'

- 18 -
2~7~8~

v = ~<v~m>~m.] (7)



The trial distribution now reads:



n(X,Y;E) = Np(X,Y) P(Eo~ C(X,Y;Eo,E) ~8)



where:



C(X,Y;Eo,E) = Lq~(X,Y)~k(EO,E) (9)



Hereafter the known energy spread function, P is normalized such
that <P> = 1.



In a preferred implementation, a least squares fit is used. More
par-ticularly, with the trial function n(X,Y;~) of equation (1) and
the multi--window acquisition resul-ts N~(X,Y) from block 34, a
solution is sought for -the number of counts caused by unscattered
photons N~(X,Y) that will minimize the sum of the squares of

differences for each pixel ~(X,Y):



~ (X,Y) = ~n(X,Y;E) - N~(X,Y]2> (10)



More particularly, in the block 15 the followin~ "fit" operation
is performed, i.e.,


P495




- = o, and (11)
N~

~
= O, where k = 1,2,....................... (12)



It can be shown that the solution of these equations is:



N~(X,Y) = <N~(X,Y) J(E)> (13)



qk(X,Y~ = ~N~(X,Y) G~(E)> (14)



where:



P(Eo,E) - <P-Q.c>.Qk(E~,E)

J(E) - - (15)
~ p2> -- ~ p~ Q~e >2
k

Gk(E) = ~k(E~,E) - <P-Ok> ~J~f ~ (16)




Note that since J(E) and Gk(E) are data independent, they can be
apriori derived as indicated in Fig. 2 by block 54 which shows
computing J(E) using ~ ,02 ....Q~c and P. The "per-pixel"
operations entail only the evaluation of the scalar product



Np = <N~ ~J(E) ~ . (17)

- 20 ~ r
P4~5



The fit, therefore, determines the per pixel Compton scatter free
count N~.



To compensate ior low statistics per pixel per energy window, the
relative constancy of scatter distributions over large spatial
domains is put to advanta~e by use of a "quasi-local" solution.
More particularly, an expanded or "large" pixel is preferably
used. Thus, if the top pixel is (XOIYO) the spatial window W is
defined as:



(XO-W)~X~(XO~W) ; (YO-W)~Y~(YO+W) (18)



of area s = (2Wtl)~



When the Compton component of the entire window s, C~ is computed,
the "per-pixel" Comp-ton ac-tivi-ty, C~ can be approximated by its
average:




C ~ - C~/s . ( 1 9 )

The measured activity in the spatial window 5 ( symmetric around
the coordinates (X,Y)) is deno-ted as N~(X,Y), and the (X,Y)-pixel
activity is denoted as N~(X,Y). A single parameter fit is done to
find the local pho-topeak count. It can be shown that this i5 Oiven
by:


- 21 -
P~195

S s
Np>(X,Y) = <N~X,Y) A,~ + Nr~(X,Y) .A,E> (20)

where:




A~ = P(E)/<P2s (21)

s
Al = [J(E) - Al ]/s (22)

Solving for N~X,Y) gives the count/pixel of the Compton free
image.



An alternative fitting method is the Maximum Likelihood Me-thod.
Given the measured ac-tivities {Nl } the ioin-t Poi5son probability
with respect to the parameters of the -trial function n(E) are
maximized; i.e., find n(E) such that




= ~ Çn(E) -n(E~
~= maximum (23)
Nl! J


or, since ~ is positive:




ln ~ = <N~ ln n(E) - n~E) - ln N~!> - maximum (24)



t can be shown that for the maximum likelihood solution:
<n(E)> - ~N~>
which enables eliminating N~ from the n(E) function.



P~,95 ~7~

(llereaf-ter (X,Y) are implicit, e.g., n(X,Y;E) = n(E). Thus from
equations (8) and (9) it follows tha-t:



n~E) = < N~>P ~qk(~C - ~k>~P) (25)



Calculating the derivative~ of ln ~ wi-th respec-t to q,~ and settlng
the resulting equation -to o as required b~ -the maximum condition,
the following equations are obtained:



N~
< (~ <~.c~P)> = ~ ; k = 1,2,.. t26)
n(E)

This is a set of non-linear coupled equations and canno-t be solved
in closed form. IJsing the mul-ti-gradient method, an iterative
solution Eor the q,cs can be obtained. Denoting oq,c as the
difEerence between q.c before and q',~ after the i-teration



oq~ = q k - q.~ . ( 27



The coupled set of equations is linearized and soluble




~Mi~oq. = Ul (28)



N~
M1J = < (~)1 <01>P) (~ -<~ ~P) > (29)
nZ(E)

2 ~ 7 `~
P4 95

N~
U = < ( ~ - < ~ P ) > ~ 3Q )
n(E)


Af-ter proper convergence of the solution for the array q,c has been
attained, the Compton free activity Nv can be obtained from:



N~ - <Ni> - ~qk<~l~> (31)
1~

Yet another alternative fit is the partial Maximum Likelihood
Solution. Suppose that the least square solution provides the
approximate functional structure of the Compton component.
However, it is desired to in-troduce the Poisson statistics by
changing the ratio of the photopeak to Comp-ton events Eraction in
order to optimize the ioint distribution. The trial func-tion,
n(E), then is



n( E) = <NOE ? t f~.P + (1-f~)C] (32)



where:




N~ .
f~ = is the photopeak fraction (33)
~N~>


and C is the least square Compton solution, normalized to t;
i.e.:



C = C /<C? (34)

- ~4 -
P495 '~ ~ 7 ~

Now, the Maximum Likelihood ~qua-tion is maximized with respect -to
a single parameter, the photopeak fraction, f~. Once f~ is
calcula-ted, the scatter-free event distribution N~ can be found
using the equation:



N~ = fv,~N~> (3~)



The optimization equation resulting from the differentiation with
respect to fF, reads:



N~tp-~)
~_ ) = O (~)
~fF~(P-)

It is soluble by an iterative New-ton-Raphson method:



<N~.~>
f F~ = fF~ (37)
<N~ .~2


where:

P-C
_ (38)
C+f~(P-C)



Yet another related me-thod of obtaining the value of NF~ involves
the semi-local Maximum Likelihood Fi-t Solution. As for the
quasi-local solution, this is implemented here as follows: First a
solution is ob-tained for the square called S surrounding the pixel
XO~Yo~ i.e.:


- .


- ~5 -
P4~ $ ~ ~

5=(XO-W)~X~(XO~w), (Y~-W)~Yc(YO~w) = (2w+l)2 t39)



Once the Compton free component of the entire window has been
o~tained, el-ther by the full or by the partial Maximum Likelihood
method; i.e., N~(X,Y) is known, the slow Compton spatial variance
is used by assumlng:



Cl = C~/s (40)



-to obtain the (X,Y)-pixel Compton free activity-




N,~ N
N ' = -- ~ <N ' - `~
p s E s (41 )


If it i5 desired to eliminate the events caused by additional
unwanted photons then block 40 is used to include such additional
unwanted photons ori~inated events in the "trial" equation.




In operation, the inventive system locally analyzes the energy
spectrum which may comprise mu].tiple energies and fits it with a
trial function comprising a combination of the unscattered
pho-topeak function and a function, representing the Compton
scattered spectrum, and a function representing other unwan-ted
photons. The function representin~ the Compton scattered spectrum
is derived usinO the Nishina-Klein formula. The Compton sca-tter
spectrum shape, therefore, inherently reflects the true




-

- 26 -
P495 ~ Q'~8~

rela-tivistic distributions of the Compton sca-tter, unlike the
previously used arbitrary polynomlals. The function representing
other unwanted photons can either be measured or computed. If
measured, the system spread function is automatically included in
-the result. If computed, the result must be convolved with the
system spread function.



The Nishina-Klein formula is recursively used to generate the
multi-scat-tered Compton distribution ~c. Then each ~(~)is convolved
with the system energy spread function to obtain C~m~ the system
dependent Compton scatter distributions. The convolved functions
are averaged or integrated for discrete windows to obtain discrete
arrays required for the calculations. The set of discrete

~u~
functions Ci is then preferably orthonormalized to reduce the
number of computations necessary and to assure that the inventive
system can provide practically Compton free ima~es within seconds
after acquisition. The coefficients of the orthonormalized
functions are parameters that provide the scattered counts per
pixel. The parameters are determined by fitting between the final
trial function comprised of the photopeak component or components,
the scatter component and on other unwanted photon components to
the measured ener~y distribution which includes both the
scattered, unscattered photons and other unwanted photons. Local
(and quasi-local) fitting can be used to expedite obtaining the
coefficients of the fit functions.


- ~7 -
P4~5 ~7~8~9

A unique approach of the invention is tha-t the parame-ters -to be
determined are coefficients of the physical Compton scatter
functions. The said func-tions have the correct high energy
threshold behavior ensuring correct fit at every point.



The inventive method also preferably improves the statistics for
the calculations for the Compton fit by a me-thod that takes
advantage of the smoothness of the Compton distribution
(quasi-local method). That is, the data in a preferred embodiment
is summed over (2n ~ 1) square pixels for the fit where n is an
integer. The values are then a-ttributed only to the central pixel
of the square. Similar calculations are done for each pixel.



Preferably a leas-t square fit is used to solve the unknown
c.oefficients, i.e., the amount per pixel of the unscattered events
(and if desired for the amount per pixel of the scattered events).
However, several variations employing the maximum likelihood fit
are also described and are within the scope of this invention.



While the invention has been described with regard to specific
embodiments, it should be understood that the description is made
by way of example only and not as a limi-tation of the scope of the
invention which is defined by the accompanying claims.


Representative Drawing

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Administrative Status

For a clearer understanding of the status of the application/patent presented on this page, the site Disclaimer , as well as the definitions for Patent , Administrative Status , Maintenance Fee  and Payment History  should be consulted.

Administrative Status

Title Date
Forecasted Issue Date Unavailable
(22) Filed 1992-06-09
(41) Open to Public Inspection 1992-12-10
Dead Application 2000-06-09

Abandonment History

Abandonment Date Reason Reinstatement Date
1999-06-09 FAILURE TO PAY APPLICATION MAINTENANCE FEE
1999-06-09 FAILURE TO REQUEST EXAMINATION

Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Application Fee $0.00 1992-06-09
Maintenance Fee - Application - New Act 2 1994-06-09 $100.00 1994-05-02
Registration of a document - section 124 $0.00 1994-06-03
Maintenance Fee - Application - New Act 3 1995-06-09 $100.00 1995-05-24
Maintenance Fee - Application - New Act 4 1996-06-10 $100.00 1996-05-01
Maintenance Fee - Application - New Act 5 1997-06-09 $150.00 1997-05-30
Maintenance Fee - Application - New Act 6 1998-06-09 $150.00 1998-05-21
Registration of a document - section 124 $50.00 1998-12-17
Owners on Record

Note: Records showing the ownership history in alphabetical order.

Current Owners on Record
GE MEDICAL SYSTEMS ISRAEL LTD.
Past Owners on Record
BERLAD, GIDEON
ELSCINT LTD.
MAOR, DOV
SHREM, YIGAL
SOIL, ADRIAN
Past Owners that do not appear in the "Owners on Record" listing will appear in other documentation within the application.
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Document
Description 
Date
(yyyy-mm-dd) 
Number of pages   Size of Image (KB) 
Office Letter 1993-01-08 1 51
Cover Page 1992-12-10 1 18
Abstract 1992-12-10 1 21
Claims 1992-12-10 14 340
Drawings 1992-12-10 2 33
Description 1992-12-10 26 654
Correspondence 1999-08-06 1 1
Fees 1996-05-01 1 39
Fees 1995-05-24 1 50
Fees 1994-05-02 1 36