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(12) Patent: | (11) CA 2176460 |
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(54) English Title: | METHOD FOR DRY BLEND COMPRESSION OF MEDICAMENTS |
(54) French Title: | PROCEDE DE COMPRESSION D'UN MELANGE SEC DE MEDICAMENTS |
Status: | Expired |
(51) International Patent Classification (IPC): |
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(72) Inventors : |
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(73) Owners : |
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(71) Applicants : |
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(74) Agent: | MCKAY-CAREY, MARY JANE |
(74) Associate agent: | |
(45) Issued: | 2007-03-13 |
(86) PCT Filing Date: | 1994-12-20 |
(87) Open to Public Inspection: | 1995-06-29 |
Examination requested: | 2001-11-23 |
Availability of licence: | N/A |
(25) Language of filing: | English |
Patent Cooperation Treaty (PCT): | Yes |
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(86) PCT Filing Number: | PCT/US1994/014639 |
(87) International Publication Number: | WO1995/017169 |
(85) National Entry: | 1996-05-13 |
(30) Application Priority Data: | ||||||
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Disclosed is a method of dry blend compression of potent drugs with low solubility, such as steroidal medicaments using directly
compressible agglomerated excipients that are not a conventional or spray dried polyalcohol or lactose. The agglomerated excipients include
mannitol, maltodextrin or corn syrup solids which hold the medicaments (s) in the crevices of the agglomerates. Also disclosed are the critical
ratios of the agglomerated excipients to steroidal agent, specifically estradiol, that is distributed uniformly throughout the dry blend and
then compressed into tablets.
Procédé de compression d'un mélange sec de substances médicamenteuses puissantes présentant une faible solubilité, telles que des médicaments stéroïdiens, à l'aide d'excipients agglomérés pouvant être compressés directement, ces excipients n'étant pas un polyalcool ou un lactose classique ou séché par pulvérisation. Lesdits excipients agglomérés peuvent être du mannitol, de la malto-dextrine ou du sirop de maïs déshydraté, et servent à retenir le(s) médicament(s) dans les fissures des agglomérats. Cette invention décrit également les rapports critiques excipients agglomérés/agents stéroïdiens, notamment l'oestradil, qui est réparti uniformément dans le mélange sec puis compressé sous forme de comprimés.
Note: Claims are shown in the official language in which they were submitted.
Note: Descriptions are shown in the official language in which they were submitted.
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Title | Date |
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Forecasted Issue Date | 2007-03-13 |
(86) PCT Filing Date | 1994-12-20 |
(87) PCT Publication Date | 1995-06-29 |
(85) National Entry | 1996-05-13 |
Examination Requested | 2001-11-23 |
(45) Issued | 2007-03-13 |
Expired | 2014-12-22 |
There is no abandonment history.
Note: Records showing the ownership history in alphabetical order.
Current Owners on Record |
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BARR LABORATORIES, INC. |
Past Owners on Record |
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APPLIED ANALYTICAL INDUSTRIES, INC. |
BEASLEY, MARTIN W. |
ENDEAVOR PHARMACEUTICALS, INC. |
GREAVES, FRANK C. |
SWARBRICK, JAMES |