Note: Descriptions are shown in the official language in which they were submitted.
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WO97/07781 PCT~P96/03718
PERSONAL ~LEA~SING SYSTEM COMPRISING POLYMERIC DIAMOND-ME~H
BATH SPO~GE AND LIOUID C~EANSER WITH HALOGENATED BIOCIDE
FIELD OF THE INVENTION
The present invention relates to a kit or cleansing system
comprising a personal cleansing hand held bath sponge; and a
liquid cleanser for bath or shower, comprising a halogenated
biocide or bacteriostat. The invention further comprises a
method for enhancing deposition of said biocide in li~uid
cleanser compositions using a diamond-mesh bath sponge.
BACKGROUND OF THE INVENTION
The use of a sponge or system instrument to apply soap li~uid
cleansing compositions to the body is well known. U.S.
Patent No. 5,295,280 to Hudson et al., for example, teach a
washing device for scrubbing the body. The washing member
ti.e., sponge) has a substantial uniform cross-section and a
substantially porous inner structure which is said to allow
water and soap to permeate the surface and interior thereof
tcolumn 2, lines 28-31) U.S. Patent No. 5,144,744 to
Campagnoli also teaches sponges tspecifically diamond-mesh
polyethylene sponge) clearly designed for bath usage tsee
claim 1).
WO 95/00116 tassigned to Procter ~ Gamble) relates to a
personal cleansing system comprising a diamond-mesh bath
sponge used in combination with a liquid cleanser comprising
a moisturizer. The diamond-mesh sponge is said to enhance
lather profile of a cleanser containing such moisturizer.
On page 12 of the World Patent application, it is mentioned
that antimicrobial may optionally be added. There is no
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mention of any particular kind of antimicrobial and no
recognition that the sponge may lead to enhanced deposition
of specific bacteriostats, i.e., halogenated (preferably
chlorinated) bacteriostats.
Finally, Dial Company has been marketing a li~uid cleanser
with chlorinated bacteriostat since about January, 1995.
Applicants have both conceived and reduced to practice the
subject invention before this date.
SUMMARY OF THF INVENTION
Applicants have now unexpectedly found that certain
bacteriostats, i.e., halogenated bacteriostats, can be
readily applied and dispersed using a diamond-mesh bath
sponge such as that disclosed, for example, in U.S. Patent
No. 5,144,744 to Campagnoli.
Specifically, the present invention comprises a system or kit
comprising:
(l) a light weight polymeric meshed personal cleansing hand
held sponge; and
(2) a li~uid cleanser comprising:
(a) an effective amount of surfactant selected from the
group consisting of soap, synthetic surfactants
(anionic, nonionic, zwitterionic and/or amphoteric,
cationic) and mixtures thereof; and
(b) .01% to 10% by weight, preferably .05% to 5% by
weight of a halogenated bacteriostat.
In a second embodiment, the invention comprises a method for
enhancing deposition of halogenated bacteriostat in a li~uid
composition comprising an effective amount of surfactant which
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method comprises applying said bacteriostat containing cleanser
to the sponge and/or desired surface (i.e., body) and applying
the sponge (with or without bacteriostat depending on whether
cleanser was added to sponge or to body) to the desired
surface. That is, the cleanser can be applied to the sponge
and then applied to the body with the sponge; or the cleanser
can be applied to the body and then rubbed on the body with the
sponge.
BRIEF DESCRIPTION OF THE FIGURES
Eigure 1 is a perspective representation of a diamond-mesh
polymeric sponge.
Figure 2 is a picture showing how the sponge can be held in the
hand
Figure 3 shows netting mesh which can be used to make the
sponge.
DETAILED DESCRIPTION
The present invention is directed to the discovery that when
certain bacteriostat containing liquid cleansers are applied to
the bodyJskin using a light weight polymeric meshed hand held
sponge, there is greater deposition/delivery of these
bacteriostats than if they had been delivered by a regular
sponge. That is, the sponge synergistically interacts with the
li~uid cleanser plus bacteriostat to enhance delivery of the
bacteriostat. The li~uid cleanser containing bacteriostat and
the mesh sponge are packaged together as a kit. The li~uid
cleanser is usually in a separate container in an amount large
enough for several uses with the sponge.
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More specifically, the personal bath or shower body cleansing
system comprises:
(A) a light weight polymeric meshed personal cleansing hand
held sponge; said polymeric mesh sponge being in a form
suitable for use as a hand held cleansing implement, said
hand held sponge having a diameter of ~rom about two (2)
inches to about eight (8) inches (5.08 cm. to about 20.32
cm.); preferably the polymeric meshed personal cleansing
hand held polymeric mesh sponge is made of polyethylene
diamond mesh and has a diameter of from 3 to 5 inches
(7.62 cm. to about 12.7 cm.);and
(B) a li~uid cleanser comprising:
(1) an effective amount of a surfactant selected form the
group of synthetic surfactants and mixtures thereof;
and
(2) a bacteriostat, preferably a halogenated
bacteriostat, more preferably selected from the group
of halogenated bacteriostats described below.
The combination of polymeric mesh sponge and cleanser plus
bacteriostat enhance the deposition of the bacteriostat. That
is the sponge interacts with the bacteriostat to enhance
delivery/deposition in a manner superior to other types of
sponges.
S~onae
The cleansing polymeric mesh sponge can be prepared from
readily available raw materials or with specially designed mesh
materials. The polymeric mesh sponge is preferably prepared
from extruded tubular netting mesh which has been prepared from
special strong and flexible polymeric material. Extruded
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WO g7/Q17781 PCTJEP96J1~3718
tubular netting mesh of this type, and particularly those
prepared from polyethylene, have been used for the covering of
meat and poultry and are readily available in industry.
The polymeric mesh sponge comprises a plurality o~ plys o~ an
extruded tubular netting mesh prepared ~rom a strong ~lexible
polymer, preferably of the group consisting of addition
polymers of ole~in monomers, and polyamides of polycarboxylic
acids and polyamines, said plys of tubular netting mesh are
folded upon itself numerous times to form a soft ball-like
polymeric mesh sponge.
The tubes or stripes of netted mesh polymer can be securely
attached by means of a nylon band or suitable closure. This
type o~ polymeric mesh sponge is disclosed in U.S. Patent No.
4,462,135, July 31, 1984, to Sanford, incorporated herein by
reference.
An example of a hand-held ball-like polymeric mesh sponge is
disclosed in U.S. Patent No. 5,144,744, to Campagnoli,
September 8, 1992, incorporated herein by reference. It is a
diamond-mesh polyethylene sponge obtained ~rom a number of
netting tubes stretched over supports, joined and bound
together at the center and then released from the supports.
Commercially available "polymeric mesh sponges" are sold by The
Body Shop and Bynum Concepts, Inc. Other suppliers include
Supremia Use in New Jersey, Sponge Factory Dominicana in the
Dominican Republic and Integrated Marketing Group in Harrison,
New York.
The following are some, although certainly not all,
specifications for suitable bath polyethylene polymeric mesh
sponges:
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Size Dia. Tubes Ea. Lenath ~otal Lenqth wt. am.
3" 2 60 cm 120 cm 15
4~ 4 50 cm 200 cm 23
5~ 4 80 cm 320 cm 37
One (1") inch = 2.54 cm; 3" = 3 x 2.54 - cm: 4" = 4 x 2.54 =
cm: etc.
Figure 1 is a perspective representation of a diamond-mesh
polymeric hand held ball-like bath sponge showing a rope handle
7 which can be used in the present invention. The ease with
which a cleansing polymeric mesh sponge can be held in the hand
for cleaning is shown in Figure 2. A security band 13 hold
the multi-layered netting mesh together to ~orm the polymeric
mesh sponge. The netting mesh that can be used in making the
polymeric mesh sponge is illustrated in Figure 3. wherein 21
represents the mesh in stretched position. The fine polymeric
filaments used in making the netting are represented by 18 with
19 representing the spot bonding of the filaments to ~orm the
open mesh 20.
Two 2 netting tubes at 60 cm length each can be used to make a
3-inch ball sponge. They can be bundled manually with a loop
or rope to form a ball-like polymeric mesh sponge. Other
designs such and rectangular gloves and washing implements made
with the mesh material also work very well in the system of the
present invention.
~iauid Cleanser - Surfactant S~stem
The present invention relates to liquid skin cleansing
compositions comprising 1 to 99% by weight, preferably 2 to
85%, more pre~erably 3 to 40% of a mild sur~actant system
comprising one or more sur~actants which alone or together have
-
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been clinically tested to be milder than soap itself as
measured by zein solubilization test (soap yields 80% zein
solubilized). Preferably, the mildness is such that zein
solubilization is in the range 10-60%. At least 10%,
~ 5 preferably at least 25% of the surfactant composition must be
anionic surfactant. In theory, as long as the anionic is
milder than soap itself, 100% of the surfactant composition may
be anionic.
A number of anionic, nonionic, cationic and zwitterionic and/or
amphoteric surfactants may be employed in the surfactant
system of the invention provided of course that the surfactant,
if used alone, or sur~actant mixture is milder than would be
soap itself as measured by the zein solubilization test.
Among suitable anionic co-actives are the alkyl ether sulfates,
acyl isethionates, alkyl ether sulfonates, sarcosinates,
sulfosuccinates, taurates and combinations thereof. Among
suitable amphoteric co-actives may be included alkylbetaines,
amidopropyl betaines, amidopropyl sultaines and combinations
thereof.
Alkyl ether sulfates of the present invention will be of the
general formula R-(OCH2CH2)nOSO3-M+ wherein R ranges from C8-C20
alkyl, preferably Cl2-Cl5 alkyl, n is an integer from 1 to 40,
preferably from 2 to 9, optimally about 3, and Ml is a sodium,
potassium, ammonium or triethanolammonium cation.
Typical commercial co-actives of this variety are listed in the
Table below:
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WO97/07781 PCT~P96/03718
Trademark Chemical Name Physical Manu-
Form facturer
Steol CS 330 Sodium Laureth Li~uid Stepan
Sul~ate
Standopol ES-3 Sodium Laureth Li~uid Henkel
Sulfate
Alkasurf ES-60 Sodium Laureth Paste Alkaril
Sulfate
Cycloryl TD TEA Laureth Paste Cyclo
Sulfate
Standapol 125- Sodium Laureth-12 Liquid Henkel
E Sulfate
Cedepal Sodium Trideceth Paste Miranol
TD407MF Sulfate
Standopol EA-2 Ammonium Laureth Li~uid Henkel
Sulfate
Alkyl ether sulfonates may also be employed for the present
invention. Illustrative of this category is a commercial
product known as Avenel S-150 commonly known as a sodium Cl2-Cl5
Pareth-15 sulfonate.
Another co-active type suitable for use in the present
invention is that of the sulfosuccinates. This category is
best represented by the monoalkyl sulfosuccinates having the
formula R2OCCH2CH(SO3--Na+)COO--M+; and amido-MEA sulfosuccinates
of the formula: RCONHCH~CH2QCCH2CH(SO3--M+)COO--M+; wherein R
ranges from C8-C20 alkyl, preferably Cl2-Cl5 alkyl and M+ is a
sodium, potassium, ammonium or triethanolammonium cation.
Typical commercial products representative of these co-actives
are those listed in the Table below:
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Trademark Chemical Name Physical Manu-
Form ~acturer
- Emcol 4400-1 Disodium Lauryl Solid Witco
Sul~osuccinate
Witco C5690 Disodium Cocoamido MEA Li~uid Witco
Sul~osuccinate
McIntyre Disodium Cocoamido MEA Liquid McIntyre
Mackanate Sulfosuccinate
CM40F
Schercopol Disodium Cocoamido MEA Liquid Scher
CMSNa Sulfosuccinate
Emcol 4100M Disodium Myristamido Paste Witco
MEA Sul~osuccinate
Schercopol Disodium Oleamido MEA Li~uid Scher
Varsul~ Disodium Solid Scherex
S13333 Ricionoleamido MEA
Sul~osuccinate
Sarcosinates may also be use~ul in the present invention as a
co-active. This category is indicated by the general ~ormula
RCON(CH3)CH2CO2--M~, wherein R ranges ~rom C8C20 alkyl, preferably
Cl2Cls alkyl and M~ is a sodium, potassium ammonium or
triethanolammonium cation. Typical commercial products
representative of these co-actives are those listed in the
Table below:
Trademark Chemical Name Physical Manu-
Form facturer
Hamposyl L-9S Sodium Lauroyl Solid W. R.
Sarcosinate Grace
Hamposyl TOC- TEA Cocoyl/Sarcosinate Liquid W. R.
Grace
Taurates may also be employed in the present invention as co-
actives. These materials are generally identi~ied by the
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WO97/07781 PCT~P96/03718
formula RCOMR'CH2CH.SO3--M~, wherein R ranges from C8-C20 alkyl,
preferably C12-C1s alkyl, R' ranges from C1-C~ alkyl, and M' is a
sodium, potassium, ammonium or triethanolammonium cation.
Typical commercial products representative of these co-actives
are those listed in the Table below: ~
Trademark Chemical Name Physical Manu-
Form facturer
Igepon TC 42 Sodium Methyl Cocoyl Paste GAF
Taurate
Igepon T-77 Sodium Methyl Oleoyl Paste GAF
Taurate
Within the category of amphoterics there are three general
categories suitable for the present invention. These include
alkylbetaines of the ~ormula RN~(CH3)2CH2CO2--M+, amidopropyl
betaines of the formula RCONHCH2CH2CH2N'(CH3)2CH2CO2--M~, and
amidopropyl sultaines of the formula RCONHCH2CH2NI(CH3)2CH2SO3--
wherein R ranges from C8-C20 alkyl, preferably C12C15 alkyl, and
M' is a sodium, potassium, ammonium or triethanolammonium
cation. Typical commercial products representative of these
co-actives are found in the Table below:
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WOg7/07781 PCT~P96/03718
Trademark Chemical Name ¦ Physical Manu-
¦ Form facturer
Tegobetaine F Cocamidopropyl Ll~uid Gold-
Betaine schmidt
Lonzaine C Cocamidopropyl Liquid Lonza
setaine
Lonzaine CS Cocamidopropyl Liquid Lonza
Hydroxysultaine
Lonzaine 12C Coco-Betaine Liquid Lonza
Schercotaine Myristamidopropyl Li~uid Lonza
MAB Betaine
Velvetex OLB- Oleyl Betaine Paste Henkel
Within the broad category of li~uid actives, the most e~fective
are the alkyl sul~ates, alkyl ether sul~ates, alkyl ether
sulfonates, sulfosuccinates, and amidopropyl betaines.
Another pre~erred sur~actant is an acyl isethionate having the
~ormula
1~l
R--C--O--CH2--CH2--SO3M
in
which R denotes a linear or branched alkyl group and M denotes
an alkali metal or alkaline earth metal or an amine.
Another surfactant which may be used are the monoalkyl or
dialkylphosphate surfactants.
Another mild surfactant which may be used, preferably used as
primary surfactant in combination with other surfactants noted
above, is sodium coco glyceryl ether sulfonate. While
desirable to use because of its mildness properties, this coco
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AGS alone does not provide optimum lather creaminess. A sodium
90/10 coconut/tallow alkyl AGS distribution is preferred for
creaminess. Salts other than the sodium salt such as TEA-,
~mm~; um, and K-AGS and chain length distributions other than
90/10 coconut/tallow are usable at moderate levels. Also, some
soap may be added to improve lather volume and speed of
lathering. Certain secondary co-surfactants used in
combination with AGS can also provide a creamier and more
stable lather. These secondary surfactants should also be
intrinsically mild. One secondary surfactant that has been
found to be especially desirable is sodium lauroyl sarcosinate
(trade name Hamposyl L, made by Hampshire Chemical).
The amphoteric betaines and sultaines noted above can be used
as the sole surfactant, but are more preferred as a co-
surfactant. Nonionics generally should not be used as the sole
surfactant in this product if high foaming is desirable;
however, they can be incorporated as a co-surfactant.
Nonionic and cationic surfactants which may be used include any
one of those described in U.S. Patent No. 3,761,418 to Parran,
Jr., hereby incorporated by reference into the subject
application. Also included are the aldobionamides as taught in
U.S. Patent No. 5,389,279 to Au et al; and the polyhydroxy
fatty acid amides as taught in U.S. Patent No. 5,312,934 to
Letton, both of which are incorporated by reference into the
subject application.
Soaps can be used at levels o~ about 1 to 10%. Soaps can be
used at higher level provided that the surfactant mixture is
milder than soap. The soaps may be added neat or made in situ
via adding a base, e.g., NaOH; to convert free fatty acids.
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13
Of course, as noted above, soaps should only be used as
cosurfactants to the extent that the surfactant system is
milder than soap alone.
A preferred surfactant active system is one such that acyl
isethionate comprises 1 to 15% by weight o~ the total
composition, an anionic other than acyl isethionate (e.g.,
ammonium lauryl ether sulfate) comprises 1 to 15% by weight of
the total composition and amphoteric comprises 0.5 to 15% by
weight of the total composition.
Another preferred active system is one comprising 1 to 20%
alkyl ether sulfate. Preferred surfactant active systems may
also contain 1 to 10% alkali metal lauryl sulfate or Cl4-Cl6
ole~in sulfonate instead of acyl isethionate.
Another preferred cleansing and moisturizing cleansing
composition can contain ingredients selected from the group
consisting of:
(a) 8% to 35% polyol;
(b) 35% to 70%, preferably 40% to 65% water;
(c) 5% to 20%, preferably 7% to 19~, of mostly insoluble
saturated (low iodine value of zero to 15) C8-C22
fatty acid potassium soap;
(d) 0.1% to 7%, preferably 0.5 to 5%, of free C8-C22 fatty
acids; and
(e) 0.5% to 5%, preferably 0.7% to about 4.5% petrolatum,
and mixtures thereof.
The polyol is selected from the group consisting of :
glycerin, glycerol, propylene glycol, polypropylene glycols,
polyethylene glycols, ethyl hexanediol, hexylene glycols, and
other aliphatic alcohols; and mixtures thereof. When propylene
glycol is used as a moisturizer, it is used at a level of at
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WO97/07781 PCT~P96/03718
14
least 5%. The polyols are preferably used at levels of from
about lO-30%.
r
The liquid cleanser can contain from about 0.5% to about 15% of
a lipophilic emollient moisturizer selected from the group
consisting of: petrolatum; esters of ~atty acids; glycerin
mono-, di-, and tri-esters; epidermal and sebaceous
hydrocarbons such as cholesterol, cholesterol esters, squalene,
squalene; silicone oils and gums; mineral oil; lanolin and
derivatives and the like; and mixtures thereof.
A preferred improved stable product with a moisturizing benefit
is achieved with the incorporation of larger sized petrolatum
particles into selected fatty acid/soap matrixes. The larger
sized petrolatum particles will vary for a liquid or semi-
solid. The key is to select the fatty acid and/or soap matrix
and to mix in the petrolatum using a m;n;m~l controlled amount
of shear to maintain larger petrolatum particles and achieve a
homogeneous stable product, e.g., an improved benefit is also
achieved in a semi-solid cleansing cream.
Any fatty acid matter (free and neutralized) used in the liquid
cleanser preferably has an Iodine Value (I.V.) o~ from zero to
about 15, preferably below lO, more preferably below 3.
BACTERIOSTAT
The bacteriostats which are the second critical component o~
the liquid cleanser composition are generally halogenated
bacteriostats. The first bacteriostats (chemicals which
control bacteria which in turn cause sweat to break down into
malodorous components) were introduced into soap bars about
1950.
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WO 97107781 PCTJEP96J03'~18
The most widely used of these are hexachlorophene;
chlorhexidine; 3,4,4'-trichlorocarbanilide; 3,4',5-tri-
bromosalicylanilide; 4,4'-dichloro-3'-(trifluoromethyl)
carbanilide; and 2,4,4'-trichloro-2'-hydroxy diphenyl ether.
The bacteriostat is used on the compositions o~ the invention
in an amount ranging ~rom 0.01~ to 10~ by weight, preferably
0.05 to 5% by weight of the composition.
The present invention is directed to the unexpected observation
that these bacteriostats, when applied with the mesh sponge
described above, were much better dispersed/deposited than if
applied with other types of sponges.
Other Inaredients
The cleansing bath/shower compositions can contain a variety of
nonessential optional ingredients suitable for rendering such
compositions more desirable. Such conventional optional
ingredients are well known to those skilled in the art, e.g.,
preservatives such as benzyl alcohol, methyl paraben, propyl
paraben and imidazolidinyl urea; other thickeners and viscosity
modi~iers such as C8-Cl8 ethanolamide (e.g., coconut
ethanolamide); pH adjusting agents such as citric acid,
succinic acid, phosphoric acid, sodium hydroxide, etc.;
suspending agents such as magnesium/aluminum silicate;
perfumes; dyes; and se~uestering agents such as disodium
ethylenediamine tetraacetate.
If present, the optional components individually generally
comprise ~rom about 0.001% to about 10% by weight o~ the
composition, but can be more or less.
Optional thickeners are categorized as cationic, nonionic, or
anionic and are selected to provide the desired viscosity.
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WO97/07781 PCT~P96/03718
16
Suitable thickeners are listed in the Glossary and Chapters 3,
4, 12 and 13 of the Handbook of Water-Soluble Gums and Resins,
Robert L. Davidson, McGraw-Hill Book Co., New York, N. Y.,
1980, incorporated by re~erence herein.
The li~uid personal cleansing products can be thickened by
using polymeric additives that hydrate, swell or molecularly
associate to provide body (e.g., hydroxypropyl guar gum is used
as a thickening aid in shampoo compositions).
A suitable thickener is hydroxy ethyl cellulose, e.g., Natrosol
R 250 KR sold by The A~ualon Company.
Another thickener is acrylated steareth-20 methylacrylate
copolymer sold as Acrysol ICS-l by Rohm and Haas Company.
The amount of polymeric thickener found useful in the present
compositions is about 0.1% to about 2%, preferably from about
0.2% to about l.0%.
The liquid cleanser can be made with from about 0.1% to about
5%, preferably from about 0.3% to about 3%, of a skin
moisturizing cationic polymer selected from the group
consisting of: cationic polysaccharides and derivatives,
cationic copolymers of saccharides and synthetic monomers,
synthetic copolymers and cationic protein derivatives.
In a second embodiment of the invention, the invention relates
to a method of enhancing delivery/deposition of bacteriostat
which method comprises applying li~uid cleanser comprising said
bacteriostat to skin or to mesh sponge and rubbing or massaging
said sponge over area where enhanced delivery/deposition is
desired.
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WO 97/077~1 PCTlEP96J03718
Specifically, the method comprises applying to a substrate
selected ~rom the group consisting of skin, a polymeric meshed
sponge and combinations thereof a liquid cleanser comprising:
(1) an e~ective amount o~ sur~actant selected ~rom
synthetic surfactants and mixtures thereof; and
(2) a halogenated bacteriostat; and
rubbing said polymeric mesh sponge against skin to spread
the liquid cleanser.
The li~uid cleanser~compositions and the bacteriostat are as
defined above.
Unexpectedly, it has been found that the mesh sponge delivers
greater amounts of bacteriostat than are delivered when other
sponges are used.
The ~ollowing examples are intended to ~urther illustrate the
invention and are not intended to limit the invention in any
way.
All percentages used are intended to be by weight unless stated
otherwise.
~xam~le 1
The polymeric mesh was packaged in a kit which contained a
li~uid cleanser comprising as follows:
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WO97/07781 PCT~P96/03718
18
INGREDIENT % BY WEIGHT
Acyl Isethionate 1-15% r
Anionic other than Acyl 1-15%
Isethionate(SLES)*
Amphoteric Surfactant** 5-15%
Sequestrant (EDTA or EHDP)0.01-0.1%
Moisturizer (e.g. cationic0.05-3.0%
polymer)
Standard additives (e.g., dyes, 0-10%
perfumes)
DP300 (Triclosan) .1-1%
Water Balance
* Sodium lauryl ether sul~ate
** Cocamidopropyl betaine
~xam~le 2
The polymeric mesh was packaged in a kit that contained a
liquid cleanser comprising as follows:
INGREDIENT % BY WEIGHT
Acyl Isethionate 1-15%
Anionic other than Acyl 1-15%
Isethionate
Amphoteric 20-30%
Moisturizer (e.g. silicone) 3-7%
Minors (perfumes, 0.1-10%
preservatives)
Triclosan 0.1-1%
Water Balance
~xam~le 3
The polymeric mesh is packaged in a kit which contains a li~uid
cleanser comprising as follows:
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19
Com~osition * (Estimated Inaredients) Estimated ~ b~ wt.
Ammonium Lauryl Sulfate 6.6
Sodium Laureth Sul~ate 5.2
Lauramide DEA 3 5
Glycerin 1.5
Isostearamidopropyl Morpholine Lactate 0.6
Citric Acid 0.2
Disodium Ricinoleamido MEA Sulfosuccinate 0.1
Triclosan 0.2
Water 80.9
Dyes, EDTA, Hydantoin
*Li~uid Dial Antibacterial Soap
Exam~le 4
The polymeric mesh is packaged in a kit which contains a li~uid
cleanser comprising as ~ollows:
Com~osition *Estimated ~ b~ Wt.
Glycerin 19.5
Sodium Soap 14.1
Disodium Lauroamphodiacetate 3.5
Cocamidopropyl Betaine 1.5
Lauramide DEA 2.0
Triethanolamine 0.9
Water 55 7
BHT Minor
Citric Acid Minor
Methylparaben Minor
Trisodium HEDTA Minor
Propylparaben Minor
Colorants Minor
Perfume Minor
*Neutrogena
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W097/07781 PCT~P96/03718
~xam~le 5
In order to show that deposition of bacteriostat (i.e.,
Triclosan~ or DP300) was greater using pouf than a sponge, the
following experiment was conducted:
First, applicants obtained a composition comprising the
following ingredients.
Inqredient ~ bY wt.
cocoamidopropyl betaine ~27%
Sodium Laureth Sulfate ~ 7%
Sodium Cocoyl Isethionate ~ 6%
Silicone ~ 5%
Water ~53%
Fragrance, Colorants, Minors ~ 2%
Applicants prepared a 25% solution of said shower gel
composition containing approx. 2.5 uCi/ml radio labeled DP300
(14C-DP300, specific activity = 157 uCi/mg). 1 ml o~ the
shower gel solution was applied to 1.2 g of pouf (original size
40 g) or 0.4 g sponge (original size 12 g), and the pouf and
sponge were s~ueezed 20 times to create lather. Piglet back
skin of 12 sq. cm in size was washed with the pouf or sponge
for 30 seconds, rinsed under running water for 30 seconds, and
patted dry with paper towel. The amount o~ DP300 deposited on
the skin was determined using autoradiography and results set
forth below.
Pouf = 0.07 ug/cm2 (S.D. =0.02); Sponge = 0.03 ug/cm2 (S.D. =
0.003)
S.D. = standard deviation (n = 4)
The results clearly show that deposition using pouf was
significantly better than deposition using a sponge.
CA 02226266 1998-01-0~
W097/07781 PCT~P96/03718
~xam~le 6
In order to further show enhanced deposition of pouf versus
sponge, applicants conducted a skin disc substantivity test as
~ollows:
Applicants prepared pig skins (shaved) and applied the products
noted ~or 30 seconds. Shower Gel A was as in Example 5 and
contained ~0.25% Triclosan; Shower Gel B was a non-germicidal
product. The treated sections were placed on agar plates
seeded with S. aureus ATCC #6538 or K. pneumoniae ATCC ~4352
for 30 minutes and then incubated at 34~C for 24 hours. The
sections were placed on the agar plates ~ 15 minutes a~ter
product application.
Results are set ~orth in Table 1 below:
TABLE 1
SKIN DISC SUBSTANTIVITY RESULTS
Inhibition Score (Average of
Sample Application 3 skin sections)
S.aureus ATCC K.pneumoniae
#6538 ATCC #4352
Shower Gel A Pouf 3.83 4.00
Shower Gel A Sponge 0.83 O.Oo
Shower Gel B Sponge 0.00 0.00
Against S. aureus, Shower Gel A applied with pouf resulted in
strong to complete inhibition o~ the organism. The product
applied with sponge (sponge from Jergens) demonstrated less
than slight inhibition. As expected, the nongermicidal Shower
Gel B displayed no inhibitor activity.
Against K. pneumoniae, Shower Gel A applied with the pouf
resulted in complete inhibition. Shower Gel A applied with the
CA 02226266 1998-01-05
WO97/07781 PCT~P96/03718
sponge and Shower Gel B/ sponge did not inhibit the bacteria
(score = 0).
From this data (see Examples 5 & 6), it is clear that pou~
deposits bacteriostat in a ~ar superior way to the sponge.
