Note: Descriptions are shown in the official language in which they were submitted.
CA 02269471 1999-04-20
WO 98/18439 PCT/C1S97/19262
1
COMPOSTTIONS FOR REDUCING
BODY ODORS AND EXCESS MOISTURE
BACKGROUND OF THE INVENTION
Body odor is most ca~runonly caused by fatty acids on skin and by malodors
firm
microbial sources. The human skin is naturally populated with numerous micro-
organisms
which are nourished by various skin secreted substances (eccrine and apocrine
sweat, and
sebum), skin ceU debris, breakdown products of the skin and the organisms
themselves.
These unpleasant body odors are mainly organic molecules which have different
structures
and functional groups, such as amines, acids, alcohols, aldehydes, ketones,
phenolics,
polycyclics, indoles, aromatics, polyaromatics, etc. They can also be made up
of sulfur-
containing functional groups, such as, thiol, mercaptan, sulfide and/or
disulfide groups.
Numerous attempts have been made to control or absorb body odors. Attempts
have
been made to deprive the microbials responsible for body odor of the
moist/humid
environment they nxd to proliferate and grow. Such efforts include the use of
powders
and/or antiperspirants. Body powders and powder-based compositions of the
prior art have
limited absorption capabilities. Antiperspirants are not always preferred in a
body odor
control product since, when used over the entire body, they may interfere with
the body's
tbennal regulatory prowess by inhibiting perspiration through the action of
astringent saps.
Additionally, such salts may be irritating to a large number of users,
particularly when
aPPIY~B ~ ~ s~itive areas such as the pelvic rte.
Other deodorant compositions aimed at combatinglcontrolling odor associated
with
skin secretions, which have been described in the chemical and cosmetic
literature, include
emulsion sticks or suspensoid sticks, aerosols, roll-ores, pads, pump sprays,
and even soap
bars. These known deodorants attempt to control odor through a variety of
means. For
instance, U.S. Patent No, 5,525,331, to Hens, issued June 11, 1996, discloses
compositions
which inhibit the growth of micro-organisms in the body~secretions. Deodorants
may also
include antibacterial compounds which help destroy/control the amount of
bacteria present on
skin, thereby minimizing odor produced via bacterial metabolism of skin
secretions.
Zeolites are laiowa odor absorbers. However, these solid odor absorbers, in
addition
to known activated charcoal odor absorbers, lose functionality when wet.
Therefore, when
by body fluids or when carried in an aqueous solution, these odor absorbers
are not
preferred as they lose their desired odor absorbent characteristics.
Furthermore, zeolites can
cause "harsh" feel if too much is deposited onto the skiut.
In addition to the aforementioned attempts at controlling andlor absorbing
body odor,
numtcous attempts have been made to mask body odors with other odors or
perfumes.
However, perfumes are often inadequate at fully concealing body odors and may
be irritating
CA 02269471 1999-04-20
WO 98/18439 PCTlUS97/19262
2
to the user when used alone for control odor.
Thus, there remains a need for an improved odor and moisture absorbing
composition, which is essentially free of irritating ingredients such as
perfumes or astringent
antiperspirants and which is safe and effective for use on the entire body.
More particularly,
there is a need for a convenient composition which is left on the skin and is
capable of
absorbing a broad spectrum of body odors and excess moisture that are not
fully suppressed
by the aforementioned means.
It has been discovered that such enhanced body odor and moisture control can
be
safely provided to the entire body by applying a composition, which is left on
the skin, which
incorporates odor absorbing, uncomplexed cyclodextrins; highly effective
moisture absorbing
ingredients; and a powder carrier. It has been discovered that a particular
advantage of the
present invention is the ability to provide convenient, non-irritating odor
and moisture
protection when applied to occluded skin areas such as the pelvic region, the
external vagina,
the panty-area, the bra-line, and skin-folds, which may be very sensitive.
Moreover, it has
been discovered that the aforementioned benefits may be delivered in a powder
carrier which
also optionally delivers skin aid benefits to the user such as protection
and/or moisturization.
These and other objects of the present invention will become readily apparent
from
the detailed description which follows.
All percentages, ratios, and parts herein, in the Specification, Examples, and
Claims
are by weight unless otherwise stated. The term "g", as used herein, means
gram. The tenor
"ml", as used herein, means milliliter.
SUMMARY OF THE INVENTION
The present invention relates to a perfume-free powder, odor absorbing
composition,
which is safe for use on skin comprising from about 0.1% to about 25%, by
weight of the
composition, of uncomplexed cyclodextrin; and a powder carrier. The present
invention also
relates to a powder odor and moisture absorbing composition which additionally
comprises
from about 5% to about 60%, by weight of the composition, of a highly
effective moisture
absorber. The compositions of the present invention may also contain
additional odor
controlling agents selected from the group consisting of zeolites, activated
charcoal, sodium
bicarbonate, antimicrobial agents, and antiperspirants.
The present invention also relates to the use of the aforementioned
compositions in
reducing body odor and excess moisture on occluded skin sites.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to a perfume-free, dry powder, odor absorbing,
and
optionally moisture absorbing composition. The present invention also relates
to the use of
the aforementioned powder composition in reducing body odor and excess
moisture from
occluded skin sites wherein the powdered composition is applied to occluded
skin. The
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
3
composition can be applied to occluded skin directly as a spray, shaken from a
bottle or
canister and applied by hand, or applied via wipe which is dry.
The composition of the present invention comprises dry ingredients preferably
having
particle sizes of from about t micron to about 100 microns; more preferred
from about I
micron to about 60 microns; and most preferred from about 1 micron to about 20
microns.
As used herein, the particle size refers to the largest dimension of the
particle and to the
ultimate (or primary) particles.
The tenor "occluded skin", as used herein, refers to regions of a human body
covered
by undergarments, such as the pelvic area, panty-area, and bra-line; and skin-
folds or
intertriginous regions, where there is continuing skin to skin contact.
The term "body fluids", as used herein, includes eccrine sweat, apocrine
sweat,
sebum, build up of sensible moisture from transepidermal water loss, vaginal
discharge,
urine, and mixtures thereof.
The term "excess moisture", as used herein, means an undesirable and/or
unhealthy
level of body fluids deposited on the human skin.
The term "body odor" as used herein means odors which are generated as a
result of
the natural functioning of a human body. Such odors include, but are not
limited to odors
produced by microorganisms of the human skin (i.e. bacterial decomposition of
skin
secretions), urine, or vaginal discharge, and mixtures thereof.
The term "entire body" means the entire external surface of human or mammalian
skin.
The term "vaginal odor" relates specifically to those body odors which emanate
from
the pelvic region of a woman, particularly the vagina and the panty area.
A detailed description of essential and optional components of the present
invention
is given below.
CYCLODEXTR1N As used herein, the term "cyclodextrin" includes any of the known
cyclodextrins such as unsubstituted cyclodextrins containing from six to
twelve glucose units,
especially alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and/or
their derivatives
and/or mixtures thereof.
The term "uncomplexed cyclodextrin" as used herein means that the cavities
within
the cyclodextrin in the composition of the present invention should remain
essentially unfilled
prior to application to skin in order to allow the cyclodextrin to absorb
various odor
molecules when the composition is applied to the skin.
Preferred cyclodextrins for use in the present invention are alpha-
cyclodextrin, beta-
cyclodextrin, gamma-cyclodextrin and/or their derivatives. More preferred are
beta
cyclodextrin, hydroxypropyl alpha-cyclodextrin, hydroxypropyl beta-
cyclodextrin,
methylated-alpha-cyclodextrin or methylated-beta-cyclodextrin. Most preferred
is beta-
CA 02269471 1999-04-20
WO 98!18439 PCT/US97/19262
4
cyclodextrin.
It is also preferable to use a mixture of cyclodextrins. Such mixtures absorb
body
odors more broadly by complexing with a wider range of odoriferous molecules
having a
wider range of molecular sizes. The levels of cyclodextrin are from about 0.1%
to about
25%, preferably from about 1% to about 20%, more preferably from about 2% to
about
15%, most preferably from about 3% to about 10%, by weight of the composition.
The complexation between cyclodextrin and odorous molecules occurs rapidly
when
wetted with body fluids. This is convenient for the user because the
cyclodextrins, while an
dry skin, will not fill their cavities with other environmental odors which
would otherwise
render them less efficient for absorbing body odors. More particularly, upon
solubilization of
the cyclodextrins by the body fluids, the isolated cavities become available
to form inclusion
complexes with the body odor molecules. Thus, ultimately, the availability of
solubilized
uncomplexed cyclodextrin is essential for an effective and efficient odor
control performance.
Cyclodextrins having small particle sizes aid in providing higher cyclodextrin
surface
availability for odor absorption and therefore are preferred. As used herein,
the particle size
refers to the largest dimension of the particle and to the ultimate (or
primary) particles.
Small particle cyclodexrins of this invention are those having a particle size
of less than about
12 microns, preferably less than about 10 microns, and more preferably less
than about 5
microns. A more complete description of the cyclodextrins, cyclodextrin
derivatives, and
cyclodextrin particle sizes useful in the present invention can be found in
U.S. Patent No.
5,429,628, Trinh et ai., issued July 4, 1995, which is incorporated herein by
reference in its
entirety.
POWDER CARRIER The cyclodextrins and other optional components useful in the
present
invention should be dispersed in a pharmaceutically-acceptable powder carrier
for
convenient, uniform application and disbursement onto the skin. The term
"phanmaceutically-acceptable", as used herein, means a powder suitable for
topical use on the
skin without undue toxicity, irritation, allergic response, and the like. The
powder carrier
also helps prevent any solubilized cyclodextrin from washing away from the
desired skin
contact. Powder carriers useful in the present invention include powders known
in the art to
be safe for human skin. Such powders include but are not limited to cornstarch
(topical
starch), talc, rice starch, oat starch, tapioca starch, microcrystalline
cellulose (for example
Avicel~), aluminum starch octenyl succinate (sold by National Starch &
Chemical Co. as
Dry Flo~ Pure, Dry Flo~ XT, and/or Dry Flo~ PC), kaolin, and mixtures thereof.
Preferred is cornstarch.
The powder carrier of the present invention will comprise from about 10% to
about
95%, preferably from about 15% to about 80%, more preferably from about 25% to
about
50%, by weight of the composition.
CA 02269471 1999-04-20
WO 98/18439 PCT/I1S97/19262
HIGHLY EFFECTIVE MOISTURE ABSORBERS Highly effective moisture absorbers
may optionally be included in the present invention to aid in reducing excess
moisture on
occluded skin. Highly effective moisture absorbers also increase the
flowability (the ability
to flow without caking due to moisture) of the compositions of the present
invention. As used
herein, the phrase "highly effective moisture absorbers" refers to silicas
(silicone dioxide),
silicates or carbonates wherein the silicates and carbonates are formed by
reaction of a
carbonate or silicate with the alkali (IA) metals, alkaline earth (I1A)
metals, or transition
metals. Preferred highly effective moisture absorbers are calcium silicate,
amorphous silicas,
calcium carbonate, magnesium carbonate, or zinc carbonate, and mixtures
thereof. Some
specific examples of the silicates and carbonates useful in the present
invention are more fully
explained in Van Nostrand Reinhold's Encyclopedia of Chemistry, 4th Ed. pages
155, 169,
556, and 849, ( 1984), which is incorporated herein by reference.
Preferred are synthetic versions of the highly effective moisture absorbers,
particularly in regards to silicas and silicates due to safety risks related
to crystalline silica.
Synthetic versions are formed by controlled chemical reactions in a
manufacturing process
rather than using a natural, mined version of these compounds which is then
further refined.
Synthetic carbonates useful in the present invention can be obtained from
various
suppliers such as Mallinckrodt or Whittaker, Clark, and Daniels. Examples of
synthetic
calcium silicates useful in the present invention are Hubersorb~ 250 or
Hubersorb~ 600
available from J.M. Huber.
It is preferred that the highly effective moisture absorbers comprise from
about 5%
to about 60%; more preferred, from about 10% to about 50%; and most preferred,
from
about 20% to about 40% by weight of the total compo
ADJUNCT ODOR CONTROLLING AGENTS Optionally, the compositions of the present
invention may comprise zeolites, carbon odor-controlling agents, sodium
bicarbonates,
antimicrobial agents and/or antiperspirant ingredients for added body odor
control.
The term "zeolite", as used herein, refers to non-fibrous zeolites. When
included in
the present invention, zeolites may be present from about 0.1 % to about 25 %,
preferably
from about 1% to about 15%, by weight of the composition. A detailed
description of
zeolites useful in the present invention is found in U.S. Patent No.
5,429,628, Trinh et al.,
issued July 4, 1995, incorporated herein by reference in its entirety.
Carbon odor-controlling agents described in U.S. Patent No. 5,429,628 may be
used
in the present invention at a level of from about 0.1% to about 25%, by weight
of the
composition.
Sodium bicarbonate is known in the art for its use as an odor absorber. An
example
of sodium bicarbonate and its use as an underarm deodorant is found in U.S.
Patent No.
4,382,079, to Marschner, issued May 3, 1983, which is incorporated herein in
its entirety by
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
6
reference. When included in the present invention, sodium bicarbonate may be
present from
about 0.1% to about 50%, by weight of the composition.
The antimicrobial agents of the present invention are selected from a group
consisting of antibacterial agents, antifungai agents, and mixtures thereof.
Antimicrobial
agents help destroy and/or control the amount of bacteria and/or fungi present
on the skin.
Preferred antimicrobial agents are zinc phenoisulfonate, zinc oxide,
triclosan, Zelec~ AM by
DuPont, zinc ricinoleate, zinc undecylenate, and mixtures thereof. More
preferred are zinc
phenolsulfonate, zinc oxide, and triclosan. Triclosan is available from Ciba-
Geigy as Irgasan
DP-300. Examples of antimicrobial agents useful in the present invention are
found in the
Cosmetic Bench Reference, 1994 Edition, page 10, which is incorporated herein
by reference.
When included in the present invention, the antimicrobials are at a level of
from about 0.01%
to about 25%. Preferably from about 0.1% to about 10%, by weight of the
present
composition.
When used on the underarms, antiperspirant ingredients may be included in the
present invention. Examples of antiperspirants known in the art are found in
the Cosmetic
Bench Reference, 1994 Edition, page 13, which is incorporated herein by
reference. When
included in the present invention, antiperspirants may be present from about
0.1% to about
25 %, by weight of the composition.
SKIN AIDS The compositions of the present invention also optionally include
skin aids.
The term "skin aids", as used herein, refers to skin protectants, emollients,
and moisturizers.
Skin protectants useful in the present invention are found in the Cosmetic
Bench
Reference, 1994 Edition, page 53; and the Monograph on Skin Protectant Drug
Products for
Over-the-Counter Human Use, 21 CFR 347. Preferred skin protectants are corn
starch,
kaolin, mineral oil, sodium bicarbonate, dimethicone, zinc oxide, colloidal
oatmeal, and
mixtures thereof. When present, the skin protectants comprise from about 0.1%
to about
80%, preferably from about 0.1% to about 30%, most preferably from about 0.1%
to about
10%, by weight of the composition.
Emollients and moisturizers useful in the present invention can be found in
the
Cosmetic Bench Reference, 1994 Edition, pages 27-32 and 46-48, incorporated
herein by
reference. Preferred emollients and moisturizers are tocopherol, tocopheryi
acetate, aloe,
vegetable oils, mineral oil, petrolatum, jojoba oil, and mixtures thereof.
More preferred are
encapsulated or spray/freeze dried emollients. The use of spray/freeze dried
or encapsulated
emollients keeps the emollients protected in the powder carrier until they are
released through
shearing (such as rubbing against undergarments or clothes) or through contact
with skin
moisture. Examples of preferred commercial spray/freeze dried aloe useful in
the present
invention are Terra-DryT"' Freeze Dried Aloe, Terra-PureT"" Freeze or Spray
Dried Aloe, and
Terra-Spray T"' Spray Dried Aloe, all from Terry Laboratories. When present,
the
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
7
emollients/moisturizers comprise from about 0.1% to about 50%, preferably from
about
0.1% to about 25%, most preferably from about 0.1% to about 10%, by weight of
the
' composition.
SLIP COMPOUNDS The present compositions may optionally comprise slip
compounds.
' The term "slip compounds", as used herein, refers to compounds which have
unique
structures which provide enhanced slip/lubrication characteristics of powders
and/or reduced
skin to skin friction between intertriginous skin sites.
Slip compounds of the present invention include polyethylene; nylon; polytetra-
fluoroethylene; silica which is in the form of microspheres, ellipsoids,
barrel-shapes, and the
like; mica, silicone (e.g. dimethicone) and metallic stearates (e.g. zinc
stearate); and mixtures
thereof. Preferred slip compounds are silicas which are in the form of
microspheres,
ellipsoids, barrel-shapes, and the like. Silica ellipsoids useful in the
present invention are
available from DuPont as ZELEC~ Sil. Silica microspheres are available from
KOBO as
MSS-500, MSS 500/3, MSS-500/H, MSS-500/3H, MSS-500/N, and MSS-500/3N.
Additionally, it is preferred that some of the silica of the present invention
be fumed silica for
increased flowability of the powder in addition to enhancing the slip
characteristics. Fumed
silica is available from Cabot Corporation (Cab-0-Sil~) and from Degussa
(Aerosil~).
When present in the compositions of the invention, the slip compounds comprise
from about 0.1% to about 35% , preferably from about I% to about 10%, by
weight of the
composition.
BINDERS The present invention may optionally also include dry or wet binders
to help
promote adhesion of the powder and active ingredients to the skin. Binders
useful in the
present invention are found in the Cosmetic Bench Reference, 1994 Edition,
pages 13-14,
which is incorporated herein by reference. Preferred binders are calcium
stearate, zinc
stearate, isopropyl myristate, magnesium myristate, silicone, and mixtures
thereof. More
preferred are zinc stearate, dimethicone, and mixtures thereof.
When included in the composition, the binders are at a level of from about 0.1
% to
about 25%, preferably from about 1% to about 15%, by weight of the
composition.
ANTI-PRURITIC AGENTS Anti-pruritic agents such as those known in the art may
be
included in the compositions of the present invention. Examples of anti-
pruritic agents useful
in the present invention are Magnesium-L-Lactate, hydrocortisone,
hydrocortisone acetate,
and colloidal oatmeal. A description of anti-pruritic agents are found in the
Handbook of
Non Prescription Drugs, 10th Edition, p. 529, 1993; which is incorporated
herein by
reference. When included in the composition, anti-pruritic agents may be
present from about
0.1 % to about 40%, by weight of the composition..
COLORANTS Colorants and dyes can be optionally added to the odor absorbing
compositions for visual appeal and performance impression. Colorants suitable
for use in the
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
8
present invention are found in the Cosmetic Bench Reference, 1994 Edition,
pages 21-22,
which is incorporated herein by reference
PROCESS OF MAKING COMPOSITIONS
The compositions of the present invention are prepared by the following steps:
creating a mixture by mixing cyclodextrin, highly effective moisture absorbers
(if present),
and optional ingredients in a powder carrier via a commercially available
mixer such as a
vee-blender, double cone blender, or ribbon blender until the mixture is
uniform; and creating
a reduced size mixture using a commercially available size reduction technique
such as
hammer milling, impact milling, ball milling, or fluid energy milling until
the desired particle
size distribution is achieved.
Since the compositions of the present invention are to be applied directly to
the skin
or hair, various applicators are useful for delivering the compositions to the
occluded skin
sites for maximum odor control. For example, the compositions are preferably
deposited in a
bottle, a canister, a spray dispenser, a manually activated spray dispenser,
or on a wipe
structure which later is contacted with the skin to transfer the composition
to the skin.
Bottles and canisters known in the art are suitable for use in delivering the
compositions of the present invention. Bottles and canisters preferably
comprise lids with
small apertures for convenient dispensing of the composition.
The composition of the present invention can also be delivered as a suspended
solution via a spray dispenser or a bottle, such that when applied or sprayed
onto the skin, the
solvent would immediately dry/volatilize off to leave a powder film. Examples
of such
suspension forms are aerosols, liquid powder suspensions, or silicone
suspensions. When
present in an aerosol composition, the powders of the present invention will
usually be
present in the range of from about 0.1% to about 15%, by weight of the
composition. The
incorporation of a powder into an aerosol is more fully explained in U.S.
Patent No.
4,078,051, to Pomot et al., issued March 7, 1978; which is incorporated herein
by reference
in its entirety. This method is not preferred however for use on sensitive
areas of the body
such as the panty-area or other occluded skin areas since skin irritations may
result from
propellants commonly used in aerosol containers.
Preferred is a manually activated spray dispenser which delivers the
composition as a
powder without the use of propellants, and without the composition being in a
solution form.
Spray dispensers useful in the present invention are described more fully in
U.S. Patent No.
2,450,205, to Rose, issued September 28, 1948; and U.S. Patent No. 2,840,277,
to Bach,
issued June 24, 1958, both of which are incorporated herein by reference in
their entireties.
Any wipe structures and/or methods of making the wipe structures commonly
known
in the art may be used in the present invention. The wipe comprises a flexible
dispensing
means. The term "flexible dispensing means", as used herein, includes papers,
cloths, non-
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
9
wovens, films, foams, sponges, rollers, pads, tissues, cotton balls, and the
like. Preferred
wipe substrates comprise a porous material, such as the non-woven substrates,
foams, or
sponges, which are capable of holding the composition within the pores of the
substrates.
Examples of cellulosic non-wovens particularly useful and economic in the
present invention
is described in U.S. Patent Number 4,191,609, Trokhan, issued March 4, 1980
which is
incorporated herein by reference in its entirety.
Techniques for combining the wipe substrates with the composition of the
present
invention are well known in the art. Examples of common methods of combining
the
composition to the wipe substrate may involve coating, immersing, dipping,
sprinkling, or
spraying, the wipe substrate with the composition of the present invention.
The composition
of the present invention is added to the wipe substrate at a level sufficient
to provide the
desired odor control and/or other desired skin benefits of the present
invention.
USE OF THE POWDER COMPOSITION
The present invention also encompasses the use of the compositions described
herein
in reducing body odor and excess moisture on a human comprising the
application of the
compositions described herein to occluded skin. The present invention also
encompasses the
use of the compositions described herein in reducing vaginal odor on a human
comprising
applying the compositions described herein onto a pelvic region, external
vagina, and/or
panty-area. However, the compositions of the present invention should not be
inserted into
the vagina, nor applied onto the vulva.
An "effective amount" of the compositions of the present invention, as used
herein,
means an amount sufficient to absorb body odor and/or excess moisture to the
point that
body odor is not discernible by the human sense of smell and excess moisture
is not present.
The compositions of the present invention are topically applied directly to
the skin or
hair. The compositions can be delivered by placing the composition into a
dispensing means
and applying an effective amount via spraying, sprinkling, shaking, or rubbing
the
composition onto the desired skin surface. Preferably the dispensing means is
a canister, a
spray bottle, or a pre-formed wipe which comprises a flexible dispensing
means.
Alternatively, the user may deposit the composition of the present invention
onto a
wipe comprising a flexible dispensing means of his or her own choosing. To do
this, the user
simply chooses a flexible dispensing means such as a washcloth or puff;
transfers the
composition of the present invention from a bottle or other suitable container
over the chosen
flexible dispensing means, and applies the composition to the desired area of
the body. The
user may also use his/her hand to apply the compositions of the present
invention. The user
may use as much or as little of the composition of the present invention as
he/she desires,
depending upon their intended use and degree of odor and moisture control
necessary.
CA 02269471 1999-04-20
WO 98/18439 PCT/L1S97/19262
The following non-limiting
examples illustrate
the formulations
and methods of use
of the present invention.
EXAMPLE I EXAMPLE II
I~redient %W/W Ineredient %W/W
Corn Starch (Topical 64.80 Corn Starch (Topical 52.20
Starch) Starch)
Silica (Microspheres)2.00 Talc 10.00
Fumed Silica 2.00 Silica (Microspheres) 3.00
Zinc Phenolsulfonate 3.00 Fumed Silica 1.00
Triclosan .20 Zinc Phenolsulfonate 3.00
Cyclodextrin 3.00 Triclosan 0.30
Aloe Vera, Freeze/Spray1.00 Cyclodextrin 13.00
Dried
Nylon-12 5.00 Aloe Vera, Freeze/Spray0.50
Dried
Zinc Stearate 7.00 Nylon-12 5.00
Tocopheryl Acetate 2.00 Zinc Stearate 3.00
Microcapsules
Dimethicone 10.00 Tocopheryl Acetate 2.00
Microcapsules
Mineral Oil 2.00
Dimethicone 5.00
'
Total 100.00 Total 100.00
Examples I and II may also comprise a colorant and/or an anti-pruitic agent
such as
Magnesium-L-Lactate.
EXAMPLE IIi EXAMPLE IV
Ingredient %W/W In reg diem %W/W
Rice Starch 54.50 Aluminum Starch Octenyl30.80
Succinate (Dry Flo~Pure)
Mica 2.00 Silica (Ellipsoids) 4.00
Silica (Ellipsoids) 2.00 Zinc Phenoisulfonate7.00
Fumed Silica 1.00 Triclosan 0.60
Triclosan 0.50 Cyclodextrin 10.00
Aluminum Chlorohydrate5.00 Aloe Vera GeU0i1 1.00
Cyclodextrin 6.00 Zeolite 10.00
Aloe Vera, Freeze/Spray1.00 Talc 13.60
Dried
Polyethylene Powder 5.00 Polyethylene Powder 7.00
Zinc Stearate 5.00 Zinc Stearate 5.00
Tocopheryl Acetate 3.00 Mineral Oil 5.00
Oil (Vit. E.
Acetate)
Dimethicone 10.00 Dimethicone 6.00
Nylon N-12 5 .00
Total 100.00 Total 100.00
Example III may also comprise a zeolite.
SUBSTITUTE SHEET (RULE 26)
CA 02269471 1999-04-20
WO 98/18439 PCT/US97J19262
11
EXAMPLE V EXAMPLE VI
In3 redient %W/W Ingredient %W/W
Tapioca Starch 54.60 Corn Starch (Topical 29.25
Starch)
Talc 4.90 Oat Flour/Colloidal 16.35
Oatmeal
Silica (Microspheres) 2.50 Silica (Microspheres)2.50
Fumed Silica 2.00 Silica (Ellipsoids) 1.50
Zinc Oxide 4.00 Kaolin 8.00
Triclosan 1.00 Zinc Oxide 2.00
Cyclodextrin 4.00 Triclosan 0.40
Aloe Vera GeU0i1 2.00 Cyclodextrin 5.00
Nylon-12 10.00 Aloe Vera GeUOiI 2.00
Zinc Stearate 6.00 Nylon-12 4.00
Isopropyl Myristate 4.00 Polyethylene Powder 4.00
Dimethicone 5.00 Zinc Stearate 10.00
Tocopheryl Acetate 5.00
Mircocapsules
Dimethicone 10.00
Total 100.00 Total 100.00
Examples V and VI may also comprise sodium bicarbonate.
EXAMPLE VII EXAMPLE VIII
Ingredient o/W/W Ingredient %WNV
Corn Starch (Topical50.80 Corn Starch (Topical 26.70
Starch) Starch)
Kaolin 14.50 Silica (Microspheres) 10.00
Silica (Microspheres)2.50 Fumed Silica 5.00
Silica (Ellipsoids) 1.50 Zinc Phenolsulfonate 3.00
Fumed Silica 0.50 Triclosan 0.20
Zinc Phenolsuifonate2.00 Cvciodextrin 3.00
Triclosan 0.20 Aloe Vera, Freeze/Spray0.10
Dried
Cyclodextrin 8.00 Magnesium Carbonate 8.00
Aloe Vera GeUOif 3.00 N~~lon-12 5.00
Nylon-12 2.00 Calcium Silicate 20.00
Polyethylene Powder 5.00 Zinc Stearate 7.00
Tocopheryl Acetate 3.00 Tocopheryl Acetate 2.00
Microcapsules '~lircocapsules
Isopropyl Myristate 2.00 Dimethicone 10.00
Dimethicone _5 00
Total 100 00 Total 100.00
Example VII and VIII may also compnse zn znt~-pruritic agent such as Magnesium-
L-
Lactate.
SUBSTITUTE SHEET (RULE 2fi)
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
12
EXAMPLE IX EXAMPLE X
Ingredient %W/W Ineredieni %W/W
Com Starch (Topical 23.20 Rice Starch 23.40
Starch)
Talc 10.00 Mica 2.00
Silica (Microspheres)10.00 Silica (Ellipsoids) 14.50
Fumed Silica 5.00 Fumed Silica 5.00
Zinc Phenolsulfonate 3.00 Triclosan 0.10
Triclosan 0.30 Aluminum Chlorohydrate 5.00
Cyclodextrin 3.00 Cyclodextrin 6.00
Aloe Vera, Freeze/Spray0.50 Aloe Vera, Freeze/SprayI.00
Dried Dried
Magnesium Carbonate 8.00 Calcium Carbonate 10.00
Nylon-12 5.00 Polyethylene Powder 3.00
Calcium Silicate 20.00 Calcium Silicate 10.00
Zinc Stearate 3.00 Zinc Stearate 7.00
Tocopheryl Acetate 2.00 Tocopheryl Acetate Oil 3.00
(Vit. E
Microcapsules Acetate)
Mineral Oil 2.00 Dimethicone 10.00
Dimethicone 5.00
Total 100.00 Total 100.00
Examples IX and X
may also comprise
a zeolite and/or
a colorant.
EXAMPLE XI EXAMPLE XII
Ingredient %W/W In; redient %W/W
Aluminum Starch Octenyl17.40 Tapioca Starch 13.10
Succinate
Silica (Ellipsoids) 8.00 Talc 4.90
Fumed Silica 8.00 Silica (Microspheres) 20.00
Zinc Phenolsulfonate 7.00 Fumed Silica 2.00
Triclosan 0.60 Zinc Oxide 4.00
Cyclodextrin 10.00 Triclosan 1.00
Aloe Vera GeUOiI 1.00 Cyclodextrin 4.00
Magnesium Carbonate 7.00 Aloe Vera GeU0i1 2.00
Calcium Carbonate 3.00 Magnesium Carbonate 5.00
Polyethylene Powder 7.00 Calcium Carbonate 4.00
Calcium Silicate 15.00 Nylon-12 10.00
Zinc Stearate 5.00 Calcium Silicate 15.00
Mineral Oil 5.00 Zinc Stearate 6.00
Dimethiicone 6.00 Isopropyl Myristate 4.00
Dimethicone 5.00
Total 100.00 Total 100.00
EXAMPLE XI1I EXAMPLE XIV
Ingredient %W/W Ingredient %W/W
Corn Starch (Topical 10.25 Com Starch (Topical 8.80
Starch) Starch)
SUBSTITUTE SHEET (RULE 26j
CA 02269471 1999-04-20
WO 98/18439 PCT/US97/19262
13
Oat Flour/Colloidal Oatmeal 8.35 Kaolin 4
00
Silica (Microspheres) 5.00 Silica (Microspheres).
5.00
Silica (Ellipsoids) 10.00 Silica (Ellipsoids) 5.00
Fumed Silica 5.00 Fumed Silica 5
00
Zinc Oxide 2.00 Zinc Phenolsuifonate.
2
00
Triclosan 0.40 Triclosan .
0.20
Cyclodextrin 5.00 Cyclodextrin 8
00
Aloe Vera GeUOiI 2.00 Aloe Vera GeU0i1 .
3.00
Magnesium Carbonate 4.00 Magnesium Carbonate 10
00
Calcium Carbonate 5.00 Nylon-12 .
2.00
Nylon-12 4.00 Polyethylene Powder 5.00
Polyethylene Powder 4.00 Calcium Silicate 25.00
Calcium Silicate 10.00 Zinc Stearate 7.00
Zinc Stearate 10.00 Tocopheryl Acetate 3.00
Microcapsules
Tocopheryl Acetate 5.00 Isopropyl Myristate 2.00
Microcapsuies
Dimethicone 10.00 Dimethicone 5.00
Total 100.00 Total 100.00
Examples XIII and XIV may also comprise sodium bicarbonate.
Prepare the above Examples by the following steps: create a mixture by mixing
cyclodextrin, highly effective moisture absorbers, optional dry ingredients,
and a powder
carrier in a commercially available mixer such as a vee-blender, double cone
blender, or
ribbon blender until the mixture is uniform; reduce the particle size of the
mixture using a
grinding/pulverizing technique such as hammer milling, impact milling, ball
milling, or fluid
energy milling; and create a second mixture by adding any liquid phase
emollients,
moisturizers, and/or skin protectants to the mixture, preferably using spray
atomization while
mixing for a more even dispersion. The second mixture can then undergo a
second
pulverizing/grinding step, and if desired, an air classifying operation.
Preparation for Apt~lication to Skin:
The compositions of the present invention, such as those formed from the
examples may be
loaded onto a wipe or deposited into a spray device or canister. The
compositions may be
applied directly onto the skin or into/onto a flexible dispensing means of the
user's choosing
for convenient application to the skin.
To prepare wipes: Coat, sprinkle, or spray the composition onto a dry flexible
dispensing
means until desired coating or thickness of the composition on the flexible
dispensing means
is achieved.
To prepare spr~w: Deposit the composition into the selected spray package.
Close the
package for storage until consumer use. To prepare a pressurized aerosol
spray, transfer the
composition into a suitable container. Pressurize and seal the container after
injection of
propellant materials.
SUBSTITUTE SHEET (RULE 26)
Dimethiicone
CA 02269471 1999-04-20
WO 98/18439 PCT/US97i19262
14
Example XV A woman with stress urinary incontinence finds that the wetness
associated
with this condition causes vaginal odor and discomfort. She wishes to reduce
both the excess
moisture and the vaginal odor. After urinating, the woman wipes her external
vagina and
pelvic region with a wipe containing the composition in Example VI. The woman
notices less
odor after using the wipes. Alternatively, the woman uses the composition in
Example XIV
and notices less odor and less moisture after using the wipes.
Example XVI A large-breasted woman finds that when she exercises, she tends to
experience sweating and skin chafing under the breasts. Before and after
exercising, she
applies the composition from Example III via a manual spray bottle. She sprays
the
composition under her breasts and the woman notices less odor and feels more
comfortable
after using the powder spray. Alternatively, the woman uses the composition in
Example
XIV and notices less odor and less moisture after using the wipes.
Example XVII A man has severe allergies to cosmetic deodorants and
antiperspirants and
avoids using such products. This results in uncontrolled and embarrassing body
odor due to
excess moisture build up. His doctor suggests applying the mild odor and
moisture absorbing
composition of Example I or VIII. The man applies the composition to his
entire body via a
spray each morning after showering, and suffers no allergic reaction. The man
notices less
odor when using the composition of either Example I or VIII, and notices a
marked reduction
of moisture with the composition of Example VIII. The man keeps a pouch of
wipes at work,
which also contain the composition of Example VIII, for convenient and
discrete
reapplication as needed, particularly on hot and sweaty days.
Example XV1II An obese woman has several large abdominal skin folds wherein
excess
moisture often accumulates causing body odor. She wishes to reduce her body
odor as well
as the excess moisture. The woman applies the composition of Example N by
sprinkling the
composition from a bottle into the palm of her hand and rubbing the
composition into the
intertriginous regions between her skin folds as well as other occluded skin
sites. The woman
notices less odor. Alternatively, the woman uses the composition in Example XI
and notices
less odor and less moisture after using the wipes.
