Note: Descriptions are shown in the official language in which they were submitted.
CA 02337772 2008-06-30
SKIN AND TISSUE CARE AND/OR TREATMENT AGENT
The invention relates to a skin and tissue care and/or treatment preparation.
In
particular, the invention relates to a preparation for care, protection and
prevention of tissue-damaging manifestations and effects and for the treatment
of
skin and tissue, wherein said preparation comprises at least one salt selected
from alkali and aikaline earth metal salts and other minerals and is
characterized
in that it contains at least one amino acid and zinc oxide and/or an inorganic
peroxide, preferably magnesium peroxide or sodium peroxide. Optionally, the
inventive preparation can additionally contain an adstringent, a binding and
adhesive agent, a humectant, an ethereal oil, tego-betaine, secondary plant
substances such as epigallocatechines, unsaturated fatty acids, liposomes,
vitamins, trace elements and antifungal and/or antimicrobial components.
Natural nutrients are essential for the health of cells and body. They serve
to
maintain and regenerate the skin as well as to stimulate metabolism and oxygen
supply of the cells. The extensive significance of nutrient supply becomes
also
more and more important in the field of skin care, cosmetic and dermatology.
Hormonal modifications, predisposition, an unbalanced and wrong diet and
unhealthy. habits, especially smoking and lack of exercise, lead to typical
manifestations of the skin, such as tissue modifications, tissue deformations
and
cellular metabolic disturbances. A well-aimed supply of nutrients harmonizes
metabolism and thus results in a natural, physiological equilibrium of the
cells.
It is generally known that vitamins, minerals and trace elements are
indispensable
to the nutrient supply of the skin. Proteins which are built up of amino acids
are an
important building component for cells and endogenous active substances, such
as enzymes and certain hormones. Polyunsaturated fatty acids, secondary plant
substances, such as flavonoids and epigallocatechines, and liposomes in
general
are becoming more and more important for health and fitness. Vitamins,
minerals
and trace elements, polyunsaturated fatty acids and bioactive plant substances
such as flavonoids are essential regulators in the metabolism and protective
nutrients for the health of the skin.
Vitamins are essential nutritional components which, for the normal functions
of
heterotrophic organisms, have to be supplied more or less obligatorily and in
correspondence to the needs, since they are only available either from
external
CA 02337772 2001-01-15
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sources or under the influence of millieu factors (e.g. intestinal flora).
Their
specific biocatalytic effect is based on the replacement of the active groups
of
enzymes which are subject to metabolical consumption. From science it is for
example known that B-type vitamins contribute to the intermediary metabolism
as
coenzymes and that vitamins C, E and R-carotene mainly function as
antioxidants.
Deficiencies resulting from insufficient supply or resorption, disorders of
the
intestinal flora or of metabolism, antivitamin-effect or increased consumption
lead
to hypovitaminosis and avitaminosis.
Furthermore, minerals and trace elements are essential regulators in the
metabolism. Zinc, magnesium and the B-type vitamins are high-performance
elements - as they activate enzymes and thus allow the metabolism of
carbohydrates, fats and protein substances. Silicon has a favorable effect on
stability and maintenance of the skin. Furthermore, it is scientifically
undisputed
that zinc has an essential function in the immune system and in the metabolism
of
the skin.
Polyunsaturated fatty acids contain linolic acid, and a- and y-linolenic acid,
which
are important starting substances for biologically active regulators in the
metabolism, such as eicosanoids and prostaglandins, and which ensure a healthy
equilibrium in the metabolism. Currently, eicosanoids and prostagiandins, also
referred to as tissue hormones, are being intensively examined by scientists
with
regard to their health stabilizing effect. The favorable influence of the
polyunsaturated fatty acids on the healthy skin function as well as on
inflammatory
processes is known. Furthermore, it is known that polyunsaturated fatty acids
of
the type of the w-3-(eicosapentaenoicacid, a-Iinolenic acid) and co-6-fatty
acids
(linolic acid, y-linolenic acid) have favorable effects on neurodermatitis and
psoriasis as well as regeneration processes induced by physical strain during
exercise. The importance of the so-called secondary plant substances, in the
special branch of science also referred to as bioactive plant substances, for
health
is now being examined as well. Bioflavonoids, which effectively support the
effects
of vitamin C with regard to the power of resistance, vascular walls and
connective
tissue also count among these natural plant substances. Furthermore, it is
known
that bioflavonoids have antioxidant properties and that they thus
synergistically
complement the effect of the vitamins C, E and (3-carotene.
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With regard to biosynthesis aspects, amino acids are divided into essential,
semi-
essential and non-essential amino acids. In addition to their function as
building
blocks for proteins, amino acids are precursors of biologically effective
compounds. Amino acids are i.a. described in L. Stryer, Biochemie, Spektrum
Akademischer Verlag, Oxford, 1994 and in Rompp Lexikon Chemie, editor J.
Falbe and M. Regitz, keyword "amino acids", Thieme Verlag, 1996 and
bibliographic references cited therein.
Liposomes are particles surrounded by single or multi-layered phospholipid
double membranes which can be loaded with hydrophilic pharmaceutical
molecules in the inner, aqueous phase. By using them as pharmaceutical
carriers,
a selective local enrichment of active substances and a delayed release of
active
substances can be achieved.
Numerous preparations for treating and preventing mycotic, microbic,
pathologic
and other tissue-damaging manifestations and effects, tissue modifications,
tissue
deformations and cellular metabolic disturbance and other forms of damage to
human tissue are commercially available. There are, for example, various
therapeutic approaches for treating skin and connective tissue problems. The
success of many of these preparations is, however, questionable, as these
preparations are unable to reach the damaged cells and/or to act in the
damaged
cells. Furthermore, many of the products that are commercially available do
not
take the active mechanism discovered by scientists into account in which the
cell
is remineralized in a natural way and metabolism is stimulated so that the
natural
inner pressure of the cell is reestablished, the cell volume is normalized and
fat
and slag substances are effectively displaced and secreted.
DE-OS-196 22 708 describes a phytobiological preparation for the topical and
parenteral incorporal application for preventing, caring for and treating
various
pathological and other endogenic and exogenic effects, modifications and
diseases, as well as for maintaining, healing and reestablishing the
homeostasis
in and at animal and human organs and soft tissue, characterized in that it
contains the following components:
(a) one or more ion-containing components and mineral salts,
(b) one or more adstringent components, one or more binding agents, a
humectant and one or more ethereal oils, and
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(c) optionally one or more vegetable extracts, a gelling agent, acid bondings,
hyaluronidase or other suitable components in an amount between 0.01
and 20%. This preparation can optionally contain calendula, hamamelis or
other homeopathic components, amino acids, enzymes, vitamins,
electrolytes, dyes, wax, emulgators, starch, vaseline, paraffines, oils,
acids,
fats, vegetable mixtures and extracts, urea, sulfate compounds, etc. Neither
does the patent application disclose examples of amino acids nor are
amino acids used in the examples.
An object'of the present invention is to provide a skin and tissue care and/or
treatment preparation which distinguishes itself by a quick effect, excellent
tolerance, a broad field of application and particularly intense deep action.
In
particular, the preparation is supposed to be applicable for care, protection,
prevention of tissue-damaging manifestations and effects and for the treatment
of
skin and tissue. The preparation according to the invention is supposed to
take
into account research results concerning the diffusion of ions through ion
channels into the intracellular space and improve microcirculation in the
cell.
An object of the present invention is solved by the provision of a composition
comprising the following components:
(a) at least one salt selected from alkali and alkaline earth metal salts and
other minerals,
characterized in that it contains
(b) at Ieast one amino acid, and
(c) zinc oxide and/or an inorganic peroxide.
Preferably zinc oxide, magnesium peroxide or sodium peroxide are used as
component (c) of the composition.
In preferred embodiments the inventive preparation can additionally comprise,
each independent of the other, at least one adstringent agent, a humectant, an
ethereal oil, tego-betaine, secondary plant substances such as flavonoids and
epigallocatechines, unsaturated fatty acids, liposomes, vitamins, trace
elements
and antifungal and antimicrobial components. Furthermore, it can comprise
usual
carriers and adjuvants as well as binding and adhesive agents and usual
solvents.
CA 02337772 2001-01-15
In a preferred embodiment the preparation of the present invention is
topically
used through direct application at the site of action.
The preparation of the present invention takes into account new research
results
concerning the diffusion of ions through ion channels into the intracellular
space.
Hereby ions of mineral salts penetrate through the upper skin layers deep into
the
cell interior of hypoderm, connective tissue and fat cells. The inventive
preparation
uses i.a. the principle of ion exchange between cell interior and cell
exterior using
high osmotic pressure which is created by the combination of active substances
of
the preparation. In this process, however, the amino acids, which help the
ions to
more effectively overcome the natural barriers of the cell membranes to reach
the
cell interior, which is the actual site of action, play an important role.
The inventive composition is in particular still effective if the functional
capability of
the cell regarding ion activity is limited. Particularly when the ion activity
is limited,
the amino acids act as additional carriers for substances which must be
infiltrated
for the intracellular activity in order to be functionally effective therein.
It has been
found that the combination of amino acids and zinc oxide and/or inorganic
peroxides improves the microcirculation in the cell, compared to the use of
salts.
The improvement can visually and biometrically be shown. If only salts are
used,
an increase of the microcirculation in the cell abruptly falls back to the
starting
value after about 1.5 hours. When the inventive composition comprising the
combination of amino acids and zinc oxide and/or inorganic peroxides is used,
the
improvement of microcirculation is, compared to the use of salt, greater, more
steady, lasts longer and approaches the starting value slowly. This allows a
better
infiltration of agents into and a better distribution of agents in the cell,
which
increases the synergistic effect.
Furthermore, in contrast to the salts alone, a combination of salts and amino
acids
has a greater positive effect on the skin physiology. This affects in
particular the
moisturing, factor, the pH value and the sebometry of the skin. When salts are
used in combination with amino acids, the salts are infiltrated into the cell
more
effectively than without amino acids, as amino acids are, on the one hand, a
key
for the cell membranes and, on the other hand, support and increase the
activation of the ion channels.
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Alkali and alkaline earth metal salts and other minerals are essential
regulators in
the metabolism. In the present invention all known alkali and alkaline earth
metal
salts and minerals, which can also be present as trace elements, can be used.
Preferred representatives of the group of alkali and alkaline earth metal
salts and
minerals that can be used in the present invention are sodium, potassium,
magnesium, calcium, silicon, zinc, manganese, copper, iron, fluorine,
chlorine,
bromine, iodine and phosphorus. Preferred trace elements are accidental trace
elements, such as silver, gold, aluminum, barium, bismuth, cadmium, chrome,
nickel, lead, tin, titanium and vanadium, and essential trace elements, such
as
chrome, cobalt, copper, fluorine, iron, iodine, manganese, molybdenum and
selenium, which are present in, for example, enzymes, chromoproteines and
hormones as constituents. The amount of the alkali and alkaline earth metal
salts
and other minerals in the inventive preparation is preferably 10 to 90 percent
by
weight, more preferably 20 to 85 percent by weight, particularly in topically
applicable agents 10 to 30 percent by weight, more preferably 10 to 25 percent
by
weight, based on the sum of all components in the preparation, depending on
the
desired osmotic effect. The alkali and alkaline earth metal salts and the
other
minerals are added in the form of usual salt compounds or organic compounds.
For example, sodium, potassium and magnesium are preferably added in the form
of their chloride salts, sodium and calcium in the form of phosphates.
The adstringent agents which are optionally used in the present invention
comprise usual compounds for this purpose. Tannin, hamamelis, rhubarb,
rhatany, and salvia are preferably used as adstringent. The amount of the
adstringent agents in the inventive preparation is preferably 0 to 30 percent
by
weight, more preferably 1 to 25 percent by weight, based on the sum of all
components in the preparation. The adstringent agents are preferably added in
a
pure form.
In the present invention usual humectants can optionally be used. Preferred
humectants are glycerin, aloe vera, collagen, desamidocollagen, collagen
hydrolysates, elastin hydrolysates, hyalomucco solution, fibrostimulin, PN 73,
Q 10, water, aloe barbadensis gel, camelia sinensis extract, hedera helix,
matricaria (camomile recutita) oil and butylene glykol. The amount of the
humectants in the inventive preparation is preferably 0 to 70 percent by
weight,
more preferably 5 to 50 percent by weight, based on the sum of all components
in
the preparation.
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Furthermore, the preparation of the present invention can optionally comprise
usual ethereal oils. Preferred ethereal oils are oils of camomile, lavender,
rosemary, camphor, mountain-pine, mint, tea tree and eucalyptus. The amount of
the ethereal oils in the preparation of the present invention is preferably 0
to 70
percent by weight, more preferably 3 to 50 percent by weight, based on the sum
of all components in the.preparation. The ethereal oils are preferably added
in a
pure form or in the form of extracts or cold-drawn and warm-drawn oils.
The preparation of the present invention can contain all known amino acids and
amino acid derivatives. Preferred amino acids and amino acid derivatives are
alanine, phenylalanine, cysteine, cystine, proline, tyrosine, serine,
histidine, glycin,
leucine, isoleucine, valine, tryptophan, arginine, lysin, asparagine and
glutamine.
Particularly cystine, cysteine, proline, serine, histidine, lycine, leucine,
isoleucine,
valine, tyrosine, arginine, lysin, asparagine and glutamine are used. Cystine,
histidine, glycin, leucine, valine, arginine, lysin and glutamine are
especially
preferred. The D-form, DL-form and L-form of the amino acids can be used,
whereby the L-form is preferred. Examples for amino acid derivatives are N-
acetylated forms, e.g. N-acetyl-L-glutamine, N-acetyl-L-tyrosine and N-acetyl-
DL-
tryptophan. The amino acids and amino acid derivatives can be used solely or
in
the form of mixtures. The amount of amino acids and amino acid derivatives in
the
preparation of the present invention is preferably 0.1 to 40 percent by
weight,
more preferably 0.2 to 30 percent by weight, most preferably 0.2 to 15 percent
by
weight, based on the sum of all components in the preparation. The amino acids
and their derivatives are preferably added in a pure form.
The preparations of the present invention are furthermore characterized by the
presence of zinc oxide and/or an inorganic peroxide. As inorganic peroxides
preferably zinc peroxide, sodium peroxide, potassium peroxide, calcium
peroxide
or magnesium peroxide are used. Zinc oxide and/or an inorganic peroxide, for
example, can be used to regulate the osmotic pressure. Surprisingly, the
combination of amino acids with zinc oxide and/or an inorganic peroxide has a
particularly good effect, compared to the use of magnesium peroxide alone. The
total amount of zinc oxide and inorganic peroxide in the preparation of the
present
invention is preferably 0.5 to 50 percent by weight, more preferably 1.5 to 40
percent by weight, based on the sum of all components in the preparation. The
amount of inorganic peroxide, if applied topically, should preferably not be
larger
CA 02337772 2001-01-15
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than 10 percent by weight, more preferably not larger than 6 percent by
weight,
most preferably not larger than 3 percent by weight, and, if applied
internally, not
larger than 20 percent by weight, more preferably not larger than 15 percent
by
weight. Zinc oxide and inorganic peroxide are preferably added in a pure form.
Optionally, tego-betaine can additionally be present in the preparation of the
present invention. The amount of tego-betaine in the inventive preparation is
preferably 0 to 25 percent by weight, more preferably 1 to 20 percent by
weight
and most preferably 5 to 10 percent by weight based on the sum of all
components in the preparation.
Optionally, the preparation of the present invention can contain all known
bioactive plant substances, also called secondary plant substances. The
secondary plant substances used in the present invention particularly comprise
carotinoids, phytosterols, saponins, polyphenols, flavonoids, terpenes,
phytoestrogens, sulfides, phytin acid and dietary fiber. Of the above-
mentioned
bioactive plant substances particularly the polyphenols, the flavonoids and
the
bioflavonoids are used in the present invention. Bioflavonoids of natural
sources
are especially preferred in the inventive preparation. The bioactive plant
substances can be present in the preferred embodiments of the preparation in a
preferred amount of 0 to 75 percent by weight, more preferably 2 to 50 percent
by
weight, based on the sum of all components in the preparation. Preferred
natural
sources for the bioflavonoids are vegetables, such as pulses, carrots,
tomatoes,
broccoli and paprika, corn, sesame, citrus fruits, green and black tea, St.
John's
wort, grapes, etc. The bioactive plant substances are preferably added in the
form
of extracts.
Optionally, all known unsaturated fatty acids can additionally be used in the
preparation of the present invention. Preferably unsaturated fatty acids that
are
included in vegetable and animal oils (such as fish oil) are used.
Polyunsaturated
fatty acids from vegetable sources are essential precursors of important
regulators of metabolism (eicosanoids and prostaglandines). The amount of
unsaturated fatty acids in the inventive preparation is preferably 0 to 70
percent by
weight, more preferably 2 to 45 percent by weight, based on the sum of all
components in the preparation. Examples for preferred pure vegetable sources
of
unsaturated fatty acids are evening primrose oil, flax oil, olive oil, wheat
germ oil,
soy oil, sunflower oil, borage oil, pumpkin seed oil and oil of the seeds of
the
CA 02337772 2001-01-15
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redcurrant. The unsaturated fatty acids are preferably added in the form of
cold-
drawn oils.
Optionally, the preparation of the present invention can furthermore
additionally
contain usual liposomes, lecithin and lipodermine. Liposomes are important, as
they control the release of vitamin A and vitamin E. That way these vitamins
are
accessible over a longer period of time. The amount of liposomes, lecithin or
lipodermine in the inventive preparation is preferably 0 to 30 percent by
weight,
more preferably 2 to 20 percent by weight, based on the sum of all components
in
the preparation.
Optionally, the preparation of the present invention can additionally comprise
epigallocatechines, preferably recovered from green tea. Through
epigallocatechines the aging of the cells can be delayed. Furthermore, they
are
important as cosubstances and serve to support the effect of micro nutrients,
such
as vitamins. The amount of the epigallocatechines in the preparation is
preferably
0 to 60 percent by weight, more preferably 2 to 30 percent by weight, based on
the sum of all components in the preparation. The epigallocatechines are
preferably added in a pure form or as extracts.
Optionally, the preparation of the present invention can additionally comprise
all
known representatives of vitamins and provitamins. Particularly vitamins A,
those
of the B-complex, C, D and E and P-carotine are preferably used in the
preparation. The amount of the vitamins in the preparation of the present
invention is preferably 0 to 75 percent by weight, more preferably 5 to 50
percent
by weight, based on the sum of all components in the preparation. The vitamins
are added both in a natural form as extracts and in a synthetic form (e.g. B-
vitamins), whereby differences in the effect of the vitamins are not linked
with this
fact.
Optionally, the preparation of the present invention can additionally comprise
antifungal and antimicrobial components. Antibiotics, bacteriostatics,
corticosteroids, cortisones, econazol nitrate, dexametasone, hydroxy benzoate,
etc. can be added to the inventive preparation. The amount of the antifungal
and
antimicrobial components in the preparation is preferably 0 to 60 percent by
weight and most preferably 2 to 30 percent by weight, based on the sum of all
components in the preparation.
CA 02337772 2001-01-15
Optionally, the preparation of the present invention can comprise all known
adjuvants, additives and carrier substances, the usual binding and adhesive
agents and solvents. Preferred examples are milk fat, unhydrogenated, partly
hydrogenated or hydrogenated soy fat, soy oil, walnut butter, glycerin,
gelatin,
pectin, lecithin, P-carotenes, sorbitol solution, iron oxide, titanium
dioxide, dyes,
fats, waxes, emulgators (e.g. IRICALMIN of the company Pentafarm Ltd., CH),
silicones, polyethylenes, polysorbitones, (meth)acryl compounds, talcum,
dragantum, xanthan-gum, starch, vaseline, dextrose, saccharin, paraffins,
acids,
preservatives and fragrances. For example pectin can be used as binding and
adhesive agent. Usual amounts of the above-mentioned substances and agents
are used, e.g. pectin up to an amount of 10 percent by weight, based on the
sum
of all components in the preparation.
The preparation of the present invention can be prepared in the usual manner
known to every person skilled in the art, for example by combining the active
ingredients with suitable, non-toxic, inert, pharmaceutically acceptable solid
or
liquid carrier materials and optionally the usual additives, adjuvants and
solvents
to a galenic form of administration. Methods for manufacturing galenic forms
of
administration, such as ointments and cremes, are for example described in H.
Sucker, B. Fuchs, P. Speiser, "Pharmazeutische Technologie", 2"d edition
(1991),
Georg Thieme Verlag Stuttgart; R. Voigt, "Lehrbuch der pharmazeutischen
Technologie", Thieme Verlag, 1976. For the preparation of the present
invention
all known forms of application are possible. Preferred forms of application
are
creme, ointment, paste, emulsion, lotion, fluid, solution, gel, powder, spray,
gelatin, foam and the like. Forms of application for internal application are
for
example capsules, tablets, coated tablets, drinking solutions and injection
solutions, for example for hypodermal injections. A depot form as form of
application is possible as well.
In principle, all known modes of application are possible for the preparation
of the
present invention. The most preferred one is the topical application, for
example
effected by applying a corresponding form of application to the skin, e.g. by
applying, rubbing on, rubbing gently in, spraying on, dabbing on, etc.
Application
is also poSsible in the form of ointment bandages or hypodermal injections.
The
preparation of the present invention can be applied once or several times a
day
and both over short and long periods of time. However, the daily dose and the
CA 02337772 2001-01-15
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frequency of the application per day depends on the recipe of the individual
inventive preparation.
Depending on the recipe, the preparations of the present invention are
suitable as
food supplement, cosmetic or pharmaceutical composition, preferably as topical
cosmetic or as topical pharmaceutical composition to be applied on the skin
and
tissue of mammals, and are for example used for the care, protection and _
prevention of tissue-damaging manifestations and effects and for the treatment
of
skin and tissue. Depending on their recipe, they are in a preferred embodiment
particularly applicable to all skin irritations (e.g. disturbed skin
physiology, sun
burn), cellulitis, wrinkles, acne, herpes, psoriasis, neurodermatitis, ozone
damage,
burns, caustic burns, cellular metabolic disturbances and other modifications
with
accumulation of tissue fluid, fat and other cellular products and cellular
catabolites, such as thickenings, edemas, hematomas, and are furthermore
applicable to, for example, hemorrhoids, rheumatism, arthrosis, and skin
cancer.
The preparation can also be applied to mucous membranes, e.g. in the digestive
system.
The present invention is further illustrated by an example.
Example 1
A preparation according to the invention having the following components was
prepared in the usual manner:
Zinc oxide 8 wt.-%
Sodium peroxide 3 wt.-%
Sodium phosphate 10 wt.-%
Calcium phosphate 6 wt.-%
Calcium chloride 5 wt.-%
Arginine 7 wt.-%
Leucine 8 wt.-%
Asparagine 5.5 wt.-%
Valine 2 wt.-%
Hamamelis 1 wt.-%
Tannin 3 wt.-%
Pectin 1 wt.-%
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Tego-betaine 2 wt.-%
Vitamin A 1 wt.-%
=Vitamin E 1.5 wt.-%
P-carotine 0.5 wt.-%
Collagen 1.5 wt.-%
Aloe Vera 2 wt.-%
Olive oil 2 wt.-%
Carotinoids 2 wt.-%
Gelatin 1 wt.-%
Liposomes 2 wt.-%
Purified water ad 100 wt.-%
The composition of the above example was applied to one leg of
probands. To the other leg control substances (placebo substances; control
leg)
are applied. The results of the examinations can be summarized as follows:
As acute reaction of the above inventive recipe an increase of
microcirculation
was found=. After about 50 minutes a significant improvement of
microcirculation
was observed, whereby a maximum increase was reached after about 100
minutes. The significant effective phase was observed after about 120 minutes.
On the control leg no changes in microcirculation were observed. As a further
reaction caused by the application of the inventive recipe, a reduction of the
fat
layer on the treated leg could be observed, while there was no modification on
the
control leg. Through these examinations it was shown that the inventive
preparation can significantly improve microcirculation and reduce the fat
layer.
Example 2
Amount (wt.-%)
Aspargine 0.30
Leucine 0.20
Valine 0.30
Arginine 0.20
Zinc peroxide 0.50
Calcium phosphate 4.50
Sodium phosphate 3.50
Zinc oxide transparent 2.00
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Calcium chloride 4.00
Magnesium sulfate 3.00
Distilled water 62.90
Hamamelis 2.50
Tego-betaine 2.00
Sorbitol 6.00
Rosemary oil 0.30
Menthol 0.30
Green tea pulvis 1.00
Ivy/bottlebrush (horsetail)/algae/green tea 5.00
Xanthan-gum 1.50
The above inventive preparation was prepared in the usual manner.
First, microcirculation on a specific skin area of a proband was measured.
After
that, the recipe of example 2 was rubbed gently into this skin area.
Microcirculation was measured immediately and, after that, every half hour
over a
period of 4 hours. Hereby microcirculation was measured in flux units. The
measuring results were plotted in relation to time. In comparison with a
commercially available product which comprises salts and magnesium peroxide
and which was, like the inventive preparation, applied to another skin area,
it was
observed that microcirculation rose earlier, maintained a higher level over a
longer
period of time and flattened to the starting value much later when the
inventive
recipe comprising a combination of certain amino acids and zinc oxide and zinc
peroxide was used. The improvement compared to the commercial product was
between 7 and 15 % at the corresponding measuring points. The results show the
improved systemic, synergistic effect of the inventive recipe compared to the
commercial product.
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Example 3
A preparation according to the invention having the following components was
prepared in the usual manner:
Amount (wt.-%)
Distilled water 71.15
Calcium phosphate 1.50
Leucine 0.20
Valine 0.30
Arginine 0.20
Aspargine 0.30
Zinc peroxide 0.25
Sodium phosphate 1.50
Zinc oxide,transparent 3.00
Karion FP liquid 4.00
Neo Dragold liquid 0.30
Calcium chloride 1.50
Magnesium sulfate 2.50
Green tea pulvis 2.00
Calendula 3.00
Hamamelis 2.50
St. John's wort 3.00
Fragrance 1677 0.30
Teatree oil Australian 1.00
Xanthan-gum 1.50
CA 02337772 2001-01-15
Example 4
A preparation according to the invention having the following components was
prepared in the usual manner:
Amount (wt.-%)
Distilled water 66.70
Zinc oxide transparent 2.00
Sodium phosphate 3.00
Aspargine 0.05
Calcium phosphate 3.50
Calcium chloride 3.50
Leucine 0.20
Magnesium sulfate 3.00
Zinc peroxide 0.30
Tego-betaine 2.00
Hamamelis 2.50
Sorbitol 5.00
YLANG-YLANG OIL II 0.10
Lotus fragrance - ethereal oil mixture 0.10
Menthol 0.05
Green tea.pulvis 0.50
IRICALMIN 3.00
GLYCODERM 3.00
Xanthan-gum 1.50
In further applications of recipes which are part of the invention,
significantly
positive effects regarding aging, elasticity, moisture, wrinkling and
tightening of
the skin were observed.
