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Patent 2377331 Summary

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(12) Patent Application: (11) CA 2377331
(54) English Title: LIGHT BEAM GENERATION AND FOCUSING DEVICE
(54) French Title: DISPOSITIF PRODUISANT ET FOCALISANT UN FAISCEAU LUMINEUX
Status: Dead
Bibliographic Data
(51) International Patent Classification (IPC):
  • A61B 18/20 (2006.01)
  • A61B 17/00 (2006.01)
(72) Inventors :
  • KUMAR, KRISHNA (United States of America)
  • LINCOLN, DANNY F. (United States of America)
  • HATCH, MICHAEL R. (United States of America)
  • EPPSTEIN, JONATHAN A. (United States of America)
(73) Owners :
  • ALTEA TECHNOLOGIES, INC. (United States of America)
  • SPECTRX, INC. (United States of America)
  • ALTEA THERAPEUTICS CORPORATION (United States of America)
(71) Applicants :
  • ALTEA TECHNOLOGIES, INC. (United States of America)
  • SPECTRX, INC. (United States of America)
(74) Agent: GOWLING LAFLEUR HENDERSON LLP
(74) Associate agent:
(45) Issued:
(86) PCT Filing Date: 2000-06-15
(87) Open to Public Inspection: 2000-12-28
Availability of licence: N/A
(25) Language of filing: English

Patent Cooperation Treaty (PCT): Yes
(86) PCT Filing Number: PCT/US2000/016576
(87) International Publication Number: WO2000/078242
(85) National Entry: 2001-12-18

(30) Application Priority Data:
Application No. Country/Territory Date
60/140,003 United States of America 1999-06-18
60/165,814 United States of America 1999-11-16

Abstracts

English Abstract




An improved light beam generation and focusing device (15, 50) is disclosed.
The device has a light source (16, 51) constructed and arranged to emit at
least one beam of light (20), and a lens assembly (17, 19, 56) constructed and
arranged to focus the at least one beam of light on a surface plane. The
device is constructed and arranged to sequentially direct the at least one
beam of light to at least two spaced locations (21, 21') on the surface plane.
The lens assembly comprises a collimating lens (17), and a spaced focusing
lens (19). The collimating lens may comprise a micro-lens, and more preferably
a cylindrical micro-lens mounted on the light source. In a first embodiment,
the device is provided with a beam steering device (28) having a beam steering
optical element (29), and a drive assembly (31) for actuating the beam
steering optical element such that the at least one beam of light is directed
to the at least two spaced locations on the surface plane. In a second
embodiment, the device is provided with a plurality of light sources mounted
to a mounting block (52), each light source emitting a separate beam of light
to separate focal points, respectively, on the surface plane.


French Abstract

La présente invention concerne des améliorations apportées à un dispositif produisant et focalisant (15, 50) un faisceau lumineux. Le dispositif comporte, d'une part une source de lumière (16, 51) construite et agencée pour émettre au moins un faisceau de lumière (20), et d'autre part un objectif (17, 19, 56) construit et agencé pour focaliser sur une surface plane le faisceau de lumière considéré. En l'occurrence, le dispositif est construit et agencé pour diriger séquentiellement le faisceau de lumière considéré sur au moins deux endroits séparés (21, 21') de la surface plane. L'ensemble objectif comporte une lentille collimatrice (17) et à distance de celle-ci, une lentille de focalisation (19). La lentille collimatrice peut comporter une micro-lentille, et de préférence une micro-lentille cylindrique montée sur la source de lumière. Selon un premier mode de réalisation, le dispositif est équipé d'un directeur de faisceau (28) comportant un élément optique directeur de faisceau (29) et un ensemble actionneur (31) servant à actionner l'élément optique directeur de faisceau de façon que le faisceau de lumière considéré soit dirigé vers les deux endroits séparés de la surface plane. Selon un second mode de réalisation, le dispositif et équipé de plusieurs sources de lumière montées un bloc de montage (52) chaque source de lumière émettant un faisceau de lumière séparé arrivant chacun sur un point focal de la surface plane.

Claims

Note: Claims are shown in the official language in which they were submitted.




19

WE CLAIM:

1. A light beam generation and focusing device for directing at least one
focused beam of light at a surface plane, said device comprising:
a light source constructed and arranged to emit at least one beam of
light; and
a lens assembly constructed and arranged to focus said at least one
beam of light on the surface plane;
said device being constructed and arranged to sequentially direct the at
least one beam of light to at least two spaced locations on the surface plane.

2. The device of claim 1, said lens assembly comprising a collimating lens
positioned with respect to the at least one beam of light and a focusing lens
spaced from the collimating lens.

3. The device of claim 2, said collimating lens and said focusing lens each
comprising a fresnel lens.

4. The device of claim 2, said collimating lens comprising a micro lens.

5. The device of claim 4, said micro lens comprising a cylindrical micro
lens.

6. The device of claim 4, said micro lens being mounted to said light
source.





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7. The device of claim 1, said light source comprising at least one laser
diode.

8. The device of claim 7, said at least one laser diode further comprising a
semiconductor laser diode chip.

9. The device of claim 7, said lens assembly having a micro lens affixed to
said at least one laser diode and through which said at least one beam of
light
passes.

10. The device of claim 9, said micro lens comprising a cylindrical micro
lens.

11. The device of claim 7, comprising a casing within which said at least one
laser diode is positioned, said lens assembly comprising a focusing lens
affixed
to said casing and spaced from said at least one laser diode.

12. The device of claim 11, said lens assembly further comprising a
collimating lens affixed to said at least one laser diode, said focusing lens
being spaced from said collimating lens.

13. The device of claim 1, comprising a beam steering device constructed
and arranged to direct said at least one beam of light to said at least two
spaced locations on the surface plane.

14. The device of claim 13, said beam steering device comprising a beam
steering optical element and a drive means for moving said optical element so




21

that said at least one beam of light is directed from a first location on the
surface plane to a second spaced location thereon.

15. The device of claim 14, said drive means comprising a stepper motor,
said optical element being selected from one of the group of optical elements
consisting of a wedge prism and a tilted or angled plane.

16. The device of claim 15, further comprising a motor controller coupled to
said stepper motor for control the movement of said beam steering device.

17. The device of claim 13, further comprising a controller coupled to said
beam steering device, said controller being constructed and arranged to
control
the movement of said beam steering device to sequentially direct said at least
one beam of light to said at least two spaced locations on the surface plane.

18. The device of claim 13, said beam steering device comprising a beam
steering optical element, said optical element being selected from one of the
group of optical elements consisting of a wedge prism, a tilted or angled
plane,
and a holographic plate.

19. The device of claim 1, said device being constructed and arranged to
sequentially direct the beam of light to at least four spaced locations on the
surface plane in a predetermined pattern.

20. The device of claim 19, said at least four spaced locations on the
surface plane defining a predetermined pattern thereon.




22

21. The device of claim 19, each of the at least four spaced locations on the
surface plane being spaced approximately eight hundred microns from each
adjacent one of said at least four spaced locations thereon.

22. The device of claim 1, said light source and said lens assembly being
fitted within a housing sized and shaped to fit in the hand of a device user.

23. The device of claim 22, further comprising a power supply within said
housing for powering said light source.

24. The device of claim 22, further comprising a beam steering device
positioned within said housing with respect to said light source, said beam
steering device being constructed and arranged to direct said at least one
beam of light to said at least two spaced locations on the surface plane.

25. The device of claim 24, further comprising a controller within said
housing, said controller being operably coupled to said power supply, said
light
source, and said beam steering device, for triggering the emission of said at
least one beam of light from said light source and for directing said at least
one
beam of light to said at least two spaced locations on the surface plane.

26. The device of claim 22, said light source comprising at least two laser
diodes mounted to a mounting block positioned within said housing.

27. The device of claim 26, further comprising a controller coupled to each
of said at least two laser diodes and adapted to sequentially operate each
said
laser diode with respect to the other for directing the beam of light to said
at
least two spaced locations on the surface plane.




23

28. The device of claim 1, said light source comprising at least two laser
diodes mounted on a mounting block.

29. The device of claim 28, said light source comprising four spaced laser
diodes mounted on a common mounting block.

30. The device of claim 29, each of said at least two laser diodes comprising
a single active element laser diode chip.

31. The device of claim 30, each said laser diode chip being spaced
approximately eight hundred microns from each adjacent one of said laser
diode chips.

32. The device of claim 30, said laser diode chips being spaced apart from
one another to form a predetermined pattern of beams of light directed to the
surface plane.

33. The device of claim 28, comprising a microcontroller coupled to each
said laser diode and adapted to sequentially operate each said laser diode
with
respect to one another for emitting said at least one beam of light and for
sequentially directing said at least one beam of light to said at least two
spaced
locations on the surface plane.

34. The device of claim 28, said mounting block comprising a copper
mounting block having a first planar surface, a spaced parallel second planar
surface, and a plurality of sides adjoining one another and each said planar
surface along their respective common edges.





24

35. The device of claim 34, each of said at least two laser diodes being
mounted to a separate one of the sides of said mounting block.

36. The device of claim 34, comprising a separate insulated wire bonding
pad on said mounting block for each respective one of said at least two laser
diodes.

37. The device of claim 1, comprising a controller constructed and arranged
to sequentially direct said at least one beam of light to said at least two
spaced
locations on the surface plane.

38. A method of generating a focused light beam directed to a surface
plane, comprising:
a) emitting at least one beam of light from a light source;
b) passing the at least one beam of light through a lens assembly
and focusing said at least one beam of light on the surface plane in
response thereto; and
c) sequentially directing the at least one beam of light to at least two
spaced locations on the surface plane.

39. The method of claim 38, comprising the step of directing the at least one
beam of light to a first location on the surface plane and then to a spaced
second location thereon using a beam steering device.




25

40. The method of claim 38, comprising the step of emitting at least two
separate beams of light toward the surface plane using at least two spaced
laser diodes.

41. The method of claim 38, comprising the step of sequentially directing the
at least one beam of light to at least four spaced locations on the surface
plane
in a predetermined pattern.

42. The method of claim 41, comprising the step of directing the at least one
beam of light to each of said at least four spaced locations on the surface
plane so that each said location is spaced approximately eight hundred
microns from each adjacent one of said spaced locations.


Description

Note: Descriptions are shown in the official language in which they were submitted.



CA 02377331 2001-12-18
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LIGHT BEAM GENERATION AND FOCUSING DEVICE
CROSS REFERENCE TO RELATED APPLICATIONS
The patent application claims priority to, and the benefit of the filing date
of, U.S. Patent Application Nos. 60/140,003 and 60/165,814, filed June 18,
1999, and November 16, 1999, respectively.
FIELD OF THE INVENTION
The invention relates in general to light beam generation and focusing
devices, such as laser porators. More particularly, the invention relates to
an
improved light beam generation and focusing device adapted to emit at least
one focused beam of light directed to at least two spaced locations on a
surface plane.
BACKGROUND OF THE INVENTION
The use of laser porators for forming micropores in the stratum corneum
has proven to be an important advancement in the healthcare field. Laser
thermal ablation devices, such as that described in U.S. Patent No. 5,885,211,
provide a means of quickly and efficiently forming a micropore in the stratum
corneum so that interstitial fluids can be easily gathered therefrom for
testing
the analytes present in the fluid. This has proven to be a very simple yet
effective way of testing for glucose, for example. Moreover, the use of laser
porators of the type described in the above-referenced patent has led to the
development of improved glucose monitoring and testing systems, such as
those developed by SpectRx, Inc. of Norcross, Georgia.
When used as a porator for forming micropores in the stratum corneum
of a person's skin, the known types of laser ablation devices emit and focus a
beam of light at a focal point on the stratum corneum for defining, i.e.
burning,
an opening in the skin layer without penetrating any deeper into the epidermis
of the person being tested. Thereafter, interstitial fluids will flow into the
opening, or can be drawn into the opening by the use of a separate device, for
example, the electro-poration device described in U.S. Patent No. 6,022,316.


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2
Additional laser ablation devices are described in U.S. Patent No. 5,643,252,
and in U.S. Patent No. 6,027,496.
What is common to the laser porators of the aforementioned patents,
and as illustrated in Fig. 1 hereof, is a laser poration device 5 provided
with a
light source 6, typically a laser of some type, which laser emits a beam of
light
directed toward a collimating lens 9. The collimating lens gathers the beam of
light and forms it into a columnar beam of light, and directs the beam of
light to
a spaced focusing lens 11. From the focusing lens, the beam of light is
directed toward and focused on a focal point 13 defined on a spaced surface
plane.
U.S. Patent No. 5,643,252 illustrates a laser ablation device of the
known type in Figs. 1 and 3 thereof, and also shows in Fig. 5A thereof an
ablation device having a spaced arrangement of prisms positioned with respect
to the light source for use in splitting the beam of light emitted from the
light
source into separate beams of light, each beam of light being simultaneously
directed to a surface plane. The device of the '252 patent also discloses, in
Fig. 5B, a powered acousto-optic modulator for use in creating separate beams
of light.
A problem with the known types of laser ablation/poration devices,
however, results from the size of the device necessary to emit and focus a
beam of light, and the need or desire to form more than one micropore in the
stratum corneum of a person being tested.
There is a need, therefore, for a portable laser poration device which
can quickly and easily emit at least one focused beam of light directed to at
least two spaced focal points on a surface plane spaced from the device.
Moreover, there is a need for such an improved device which remains relatively
compact, yet flexible enough for use in a variety of applications. There is
also
a need for an improved laser porator which will more efficiently gather the
beam of light emitted from the light source, focus the beam of light, and
direct it
to the at least two spaced locations on the surface plane.


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3
SUMMARY OF THE INVENTION
The present invention provides an improved light beam generation and
focusing device adapted for use in emitting and directing at least one focused
beam of light to at least two spaced locations on a surface plane, which may
include the stratum corneum of a person, and which overcome some of the
design deficiencies of the known art. The light beam generation and focusing
device of this invention provides a simple and efficient device which allows
for
a greater degree of flexibility in use when compared to the known types of
laser
porators. Moreover, the relative simplicity of the device of this invention,
when
contrasted with the known laser porators, addresses the problems of
efficiently
and cost effectively focusing at least one beam of light on a surface plane
for
defining an opening therein, and more preferably for defining an opening in at
least two spaced locations therein.
The invention attains this degree of flexibility, as well as simplicity in
design and construction, by providing an improved light beam generation and
focusing device having a light source constructed and arranged to emit at
least
one beam of light, a lens assembly constructed and arranged to focus the at
least one beam of light on the surface plane, and which is also constructed
and
arranged to direct the at least one beam of light to at least two spaced
locations on the surface plane.
The lens assembly of the device comprises a collimating lens positioned
with respect to the at least one beam of light, and a focusing lens spaced
therefrom. The collimating lens may comprise a micro-lens, and more
particularly may comprise a cylindrical micro-lens mounted directly to the
light
source. The light source may comprise a laser diode, and may further
comprise a single active element laser diode chip, or multiple active element
laser diode chips.
The device may also include, in one embodiment, a beam steering
device constructed and arranged to direct the at least one beam of light to
the
at least two spaced locations on the surface plane. The beam steering device


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4
includes a beam steering optical element, and a drive motor, or drive motors,
for moving the optical element so as to direct the at least one beam of light
from a first location on the surface plane to a spaced second location
thereon.
The drive motors) may comprise a stepper motor, or other motors designed to
function similarly.
The beam steering optical element may comprise a wedge prism or a
tilted or angled plane in a first embodiment, each of which is driven by the
drive
motor. The optical element may also comprise a holographic or a diffractive
optical imaging element in a second embodiment thereof such that a motor is
not required, the optical element serving both to split the optical energy,
i.e. the
at least one beam of light, and to direct the at least one beam of light to
the at
least two spaced locations on the surface plane.
In another embodiment of the invention, the light beam generation and
focusing device will be sized and shaped to fit within the hand of the device
user, and will comprise a power supply, a light source, and a beam steering
device fitted within the housing for directing the at least one beam of light
emitted therefrom to the at least two spaced locations on the surface plane,
or
alternately may comprise at least two separate light sources within the
housing,
i.e., two separate laser diodes, used to emit separate beams of light.
Accordingly, in still another embodiment of the invention, the light source
will comprise at least two laser diodes mounted on a common mounting block.
Each of the laser diodes will preferably comprise a laser diode chip, although
other types of suitable light emitting sources may be used. Each laser diode
chip will be spaced approximately eight hundred (800) microns apart from each
adjacent one of the laser diode chips for forming a predetermined pattern of
light beams directed toward the surface plane.
The device also includes a controller/microprocessor coupled to the light
source and/or to the beam steering device, where one is provided, for
controlling the emission of the at least one beam of light, and for directing
the


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at least one beam of light to the at least two spaced locations on the surface
plane.
An improved method of emitting a focused beam of light directed to a
surface plane results from the unique construction of this invention, the
method
5 including the steps of emitting at least one beam of light from a light
source,
passing the at least one beam of light through a lens assembly for being
focused on the surface plane, and sequentially directing the at least one beam
of light to at least two spaced locations on the surface plane with the
device.
The step of sequentially directing the at least one beam of light may
include the step using a beam steering device, or using at least two spaced
light sources. Moreover, the method may include the step of sequentially
directing the at least one beam of light to at least four spaced locations on
the
surface plane for forming a predetermined pattern thereon.
The objects, features, and advantages of the present invention will
become apparent upon reading the specification, when taken in conjunction
with the accompanying drawings, to which the invention is directed.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a schematic illustration of a known type of laser poration device.
Fig. 2 is a schematic illustration of a first embodiment of the light beam
generation and focusing device of this invention.
Figs. 3A and 3B are schematic illustrations of a second embodiment of
the light beam generation and focusing device of this invention.
Fig. 4 is a schematic illustration of the light beam generation and
focusing device of Figs. 3A and 3B.
Fig. 5 is a schematic illustration of a combined light source and lens
assembly for use with the light beam generation and focusing device of this
invention.


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6
Figs. 6A-6C illustrates three separate embodiments of a beam steering
optical element that may be used as a part of the beam steering device of the
invention.
Fig. 7 is a partial schematic perspective illustration of a third
embodiment of the light beam generation and focusing device of this invention.
Fig. 8 is a partial exploded schematic view of the embodiment of the
light beam generation and focusing device of Fig. 7.
Fig. 9 is a schematic illustration of the light beam generation and
focusing device of Figs. 7 and 8.
Fig. 10 is a schematic side elevational view along line 10-10 of Fig. 7.
Fig. 11 is a schematic illustration of a fourth embodiment of the light
beam generation and focusing device of this invention.
Fig. 12 is a schematic illustration of a fifth embodiment of the light beam
generation and focusing device of this invention.
Fig. 13 is a circuit diagram of the control circuit used in connection with
the embodiments of the light beam generation and focusing device of Figs. 2-
12.
DETAILED DESCRIPTION OF THE INVENTION
Referring now in detail to the drawings, in which like reference
characters indicate like parts throughout the several views, a first
embodiment
of the light beam generation and focusing device of 15 of this invention is
illustrated in Figs. 2 and 5. The device 15 is provided with a light source
16,
here a suitable laser diode, for example those laser diodes manufactured by
High Power Devices, or other laser diodes, also referred to as semiconductor
diode lasers.
The light source 16 will preferably be a low-cost solid state laser diode
capable of delivering a beam a light having an emission wave length of
approximately eight hundred nanometers, or at such other wave lengths and
power levels necessary for the intended purposes, which may include, but are


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not limited to, the forming of a micropore in the stratum corneum of a
person's
skin. Also, it is anticipated that the laser diode will be sized such that it
will be
sufficiently small so as to be portable enough to fit within a hand-held
housing.
Although not shown in Figs. 2 and 5, the light source 16 will be powered by a
suitable power source 25, which may include batteries, including, but not
limited to, lithium, lithium-ion, nickel-metal hydride, and nickel-cadmium
batteries; a capacatively charged power source, for example a storage
capacitor; or a regulated wall type power supply capable of converting an
electrical line voltage into the voltage needed to operate the device.
As shown in Figs. 2-5, the light source 16 is fitted with a collimating lens
17 mounted directly to the light source. It is envisioned that the collimating
lens
17 will comprise a micro lens, and may also therefore include a cylindrical
micro-lens adapted to gather the light emitted from the light source 16, and
to
collimate the light so that it is emitted therefrom as an aligned and oriented
beam of light directed toward a spaced focusing lens 19. The focusing lens
will
direct the beam of light toward a focal point 21 defined on a spaced surface
plane "S", which is any desired surface plane, to include the stratum corneum
of a person, or any other surface on which the beam of light is to be focused.
Fig. 5 illustrates an alternate embodiment of the arrangement of the
device 15 shown in Fig. 2, in that the focusing lens 19 is affixed to a casing
23,
the casing in turn being affixed to the light source 16 along with the
collimating
lens 17 so that the light source and lens assembly are formed as one compact
assembly designated by the reference character "L." The construction shown
in Fig. 5 offers a compact and efficient arrangement which is advantageous for
use in a hand-held light beam generation and focusing device.
A second embodiment of the light beam generation and focusing device
15 is illustrated in Figs. 3A & B, and in Fig. 4. In this embodiment of the
device
the light source 16 is again provided with a collimating lens 17, a micro-
lens,
fitted directly to the light source, with a spaced focusing lens 19 for
focusing
the beam of light 20. However, and unlike the first embodiment of this


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8
invention, the device 15 includes a beam steering device 28 constructed and
arranged to receive the focused beam of light, and to direct the beam of light
to
at least two spaced locations on the surface plane. This is accomplished by
positioning a beam steering optical element 29 between the focusing lens 19
and the surface plane S, such that the beam steering optical element
intercepts the focused beam of light, and selectively directs the beam of
light to
a first focal point 21 on the surface plane, and then to at least a second
spaced
focal point 21' on the surface plane, shown in broken lines.
The beam steering device will include in a first embodiment thereof a
drive assembly 31, best shown in Figs. 3A and 3B, comprised of a drive motor
32, here a stepper motor, a mounting collar 33 for mounting the stepper motor
to the casing 23 of the light source 16, a gear train 35 having a drive gear
35'
rotated by the stepper motor 32, a driven gear 35" affixed to the beam
steering
optical element 29, and a motor controller 36 for operating the stepper motor
so that it will move the beam of light 20 from the first focal point 21 to at
least
the second spaced focal point 21', as shown in Fig. 4. Although not shown, it
is envisioned that more than one drive motor may be provided as a part of the
beam steering device.
Referring now to Figs. 3A and 3B, the light beam generation and
focusing device 15 includes a hand-held housing 24 in which the device is
fitted. The housing is sized and shaped to fit within the hand of the device
user, and is provided with a suitable power supply 25, as described above. It
is
preferred, although not required, that the power supply be battery powered,
and more preferably, that it be one of the known types of rechargeable
batteries.
As shown in Figs. 3A and 3B, the device 15 will include the compact
collimating lens assembly shown in Fig. 5, which assembly will have the beam
steering device 28 fitted thereto by the mounting collar 33 as described
above.
A controller 27, also referred to herein interchangeably as a microprocessor
or
microcontroller, is provided as a part of the device, and is positioned within
the


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9
housing 24 for controlling the light source such that a pulsed laser beam is
generated and emitted therefrom, and which also signals a motor controller 36
for controlling the operation of the beam steering device drive motor.
The construction of the controller 27 and of the motor controller 36 is not
shown in greater detail as these are otherwise conventional control or
microprocessor chips adapted for use in both controlling the operation of the
light source 16, as well as operating the motor 32. Each of the controller 27
and the motor controller 36, as well as the controller 64 described
hereinbelow,
therefore comprises a conventional microprocessor available from a variety of
vendors/manufacturers in known constructions, and which will either be pre-
programmed or programmable, as known, and will also be provided with a
memory or access to a memory storage and retrieval device.
Moreover, although a stepper motor 32 is disclosed herein for use in
driving the beam steering optical element 29, it is understood by those
skilled
in the art that any suitable motor, or controllable actuator, including, but
not
limited to a servomotor, a solenoid, a pneumatic cylinder, a hydraulic
cylinder,
or the like, could be used for this purpose, as desired. A stepper motor is
preferred here for its ability to precisely control the movement of the beam
steering device.
The actual physical construction of the device 15 shown in Figs. 3A and
3B is not discussed in greater detail for the reason that the manner and
method of assembling the components is well known, and will comprise the
use of a PC board to which the controllers 27 and/or 36 will be affixed, and
to
which the power supply 25 will also be connected through the known types of
electronic circuits, as is the light source 16.
Although, the device 15 shown in Figs. 3A and 3B uses the compact
light source and lens assembly L shown in Fig. 5, it is also envisioned that
the
device could use conventional spaced collimating and focusing lenses which
are not affixed to or mounted on the light source 16 and the casing 23,


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respectively, as shown, for example, in U.S. Patent No. 5,885,211 to Eppstein
et al., the provisions of which are incorporated fully herein by this
reference.
Moreover, although the beam steering optical element 29 shown in Fig.
4, as well as in Fig. 6A is an inclined optical plane 38, it is anticipated
that other
5 embodiments of the beam steering optical element may be used, as shown in
Figs. 6B and 6C. Referring now to Fig. 6B, the beam steering optical element
29 may comprise a wedge shaped prism 39 positioned anywhere in the optical
beam path, but which is preferably positioned between the focusing lens (not
shown) and the focal point 21 on the surface plane (Fig. 4). The prism 39 will
10 be moved by the drive motor 32, the prism being held by a suitable support
structure or framework with respect to the light source 16 of Figs. 2-5. Both
the
optical plane and the prism will be rotated about a central axis "A"
positioned
coaxially with the axis of the light source for directing the beam of light to
the at
least two spaced locations 21, 21', on the surface plane.
The optical plane 38 comprises a tilting, flat optical window, or plate,
which may be positioned between either the light source and the collimating
lens, or between the focusing lens and the surface plane. The focal point of
the beam of light can thereby be steered by tilting this flat optical window
in the
x and y dimensional planes, where the thickness of the window affects the
beam of light via refraction of the light beam leading to a lateral
translation of
the focal point in an amount related to the degree of tilt in the desired
direction.
The steering of the beam of light in this fashion offers some cost advantages
over an optical wedge in that an optical window/plane is a simpler element to
fabricate.
Each of the optical plane 38 of Figs. 4 and 6A, and the prism 39 of Fig.
6B comprise an optical quality glass or plastic element, respectively, the
plane
38 being a plate or sheet of glass or plastic, whereas the prism 39 will
shaped
as a prism of any suitable construction or configuration. All that is required
is
that the plane 38, prism 39 be suitable for bending light to be incident at
the
required distance from the optical axis, and be provided with suitable


CA 02377331 2001-12-18
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11
transmissability and anti-reflective coatings at the desired wavelengths. The
optical plane of Figs. 4 and 6A is mounted in an inclined fashion in a holder,
while the prism is mounted in an erect manner.
Yet another embodiment of the beam steering device 28 is shown in Fig.
6C, which embodiment does not utilize the drive assembly 31 of Figs. 3A and
3B. Instead, a holographic or diffractive optical element 40 is used which
masks the beam of light received from the upstream light source, such that
discrete beams of light 20 are passed toward the surface plane to the separate
focal points 21, 21" thereon. This type of holographic or diffractive imaging
into
multiple focal points is preferably done using a monochromatic light source,
such as a laser diode. Additionally, when using these types of holographic or
diffractive optical elements, to ensure an equal distribution of optical
energy to
the various focal points, it is preferable to mask the first order image and
use
only the multiple second order images emitted from the element.
Although, reference has been made hereinabove to a first focal point 21
and a second focal point 21', or 21 ", respectively, it is envisioned that the
beam
steering embodiments of the device 15 will be used to direct the beam of light
to at least two, and as many more spaced locations/focal points on the surface
plane as desired. A preferred light pattern here is shown as having four
spaced focal points on the surface plane spaced at least eight hundred
microns apart from one another for defining a predetermined pattern of focal
points, or openings if the device is being used to define a plurality of
micropores through the stratum corneum and into the viable layers of the
epidermis of a person. The beams of light emitted from the device, in each of
its several embodiments, will preferably penetrate to a depth of at least 80
to
100 microns beneath the outermost surface of the skin layers. This type of
construction is desirable for allowing the interstitial fluids to be collected
from a
plurality of closely grouped micropores for expediently testing the
interstitial
fluids for analytes or for any other desired purpose(s).


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
12
It is envisioned, therefore, that the beams) of light can be formed into
any type of geographic pattern capable of being defined on a surface plane,
which may thus include a hexagonal shaped pattern, a rectangular pattern, a
circular pattern, or a pattern of any desired type, based upon the operating
program stored within the controller 27 and/or the motor controller 36 of the
device, all as desired by the end user of the device, based on the known types
of programmable control/microprocessor chips available in the art, and the
known methods of programming same.
A fourth embodiment of the light beam generation and focusing device
50 is illustrated in Figs. 7-9. Referring first to Figs. 7 and 8, in this
embodiment
of the invention, rather than using a beam steering device 28 as shown in
Figs.
3A - 4, a plurality of light sources 51, again laser diodes as described
above,
are mounted to a common mounting block 52 in the desired geometric pattern
to be defined on the surface plane of Figs. 10-12. Each one of the light
sources 51 will be mounted on the mounting block, which also functions as
either a ground or an electrode, by an insulated wire bonding pad 54 for
forming either the anodic or cathodic lead for the laser diode, respectively,
whereas the respective cathodic/anodic leads will be formed through the
known wire bonding techniques. The emitting facets of the respective laser
diodes will preferably be aligned along the "z" dimensional axis such that
when
collimated and re-imaged to focus on the surface plane, the focal point of
each
individual laser diode will lie on the common surface plane.
Each of the insulated wire bonding pads 54 will be separately positioned
within a respective one of the depressions 54' defined within the mounting
block, with the laser diodes being soldered or otherwise bonded to the
heatsink
and wired to the bonding pads, and thus to the mounting block 52. The wire
bonding pads are insulated from the mounting block so that the block can
provide the "opposite" electrical supply, be it positive, or negative, as
desired.
The mounting block, be it a common ground or a common positive, will


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
13
preferably comprise a block of high thermal conductivity copper, or other high
quality thermally conductive heatsink materials.
Four spaced light sources 51, illustrated in Fig. 7 as four separate laser
diodes, together define a predetermined pattern shown by the broken lines as
designated by the reference character "D". Each of the respective laser diodes
will be spaced approximately eight hundred microns apart from each adjacent
laser diode within this predetermined pattern. Here, rather than emitting a
single beam of light with a single light source and then "steering" the beam
of
light, a plurality of separate light beams, in this instance four light beams,
will
be emitted from the device in sequential fashion toward the surface plane S.
This eliminates, entirely, the need for any kind of mechanical device
interposed
between the respective light sources 51 and the surface plane. As with the
beam steering embodiment of the invention, the beams of light emitted from
the respective light sources are capable of being formed into any type of
geographic pattern capable of being defined on a surface plane, as governed
by the mounting pattern of the laser diodes on the mounting block.
Referring now to Fig. 9, the construction of the light beam generation
and focusing device 50 is described in greater detail. The device 50 is
provided with four light sources 51, each of which comprises a laser diode,
for
example a single active element laser diode chip. Each laser diode is affixed
to the mounting block 52 as an assembly 51A. The assembly fits within a lens
holder 55, to which a lens assembly 56 is fitted. The lens assembly 56, as
shown in Fig. 9, includes a collimating lens 58 and a spaced focusing lens 59.
A casing 60 is fit over the lens assembly 56, and hold the lens assembly in
position with respect to the lens holder 55 and the laser diode assembly 51A.
The casing 60, lens assembly 56, and laser diode assembly 51A are
fitted within a housing 62, the housing being sized and shaped to be held
within the hand of a user. A suitable power supply 63 is provided within the
housing, this being the same type of power supply as is power supply 25,
described above.


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
14
The device 50 will include a controller/microcontroller 64, a known type
of microprocessor, as described hereinabove, and is provided with a resistor
pin network 66 which provides a series of pull down resistors used to prevent
the lasers from firing without the proper actuating command. The device 50
also includes a three pin header 67, provided as a programming port for the
controller 64, in known fashion. The controller 64, as well as the resistor
network 66, and the header 67 are fit within an electronics compartment
defined within the housing, with an electronics compartment cover 68 fitted
thereto for enclosing the electronics controls of the device within the
housing.
Still referring to Fig. 9, a plurality of spaced pogo pins 70 are provided
for connection to the power supply 63, assuming the power supply comprises
batteries, as described hereinabove, batteries being preferred for providing
ease of portability in the use of the device. The housing is also provided
with a
power switch 71 for operating the device, and includes a plurality of
conventional fasteners 72 for affixing the laser diode assembly 51A to the
housing, and a plurality of fasteners 74 for affixing the electronics
compartment
cover to the housing as well. The device 50 is also provided with a bi-color
LED 75 for the purpose of indicating a ready status in which the device is
charged and ready for use, and a firing status indicating that the light
source,
the laser diode or diodes, are firing. For example, a flashing green light may
be used to indicate the ready status, and a flashing red or amber light to
indicate that the device is firing, and to meet the appropriate BRH/FDA laser
safety warning requirements.
Referring now to Fig. 10, the embodiment of the device shown in Figs.
7-9 is shown in a schematic side elevational view. Two spaced light sources
51, a pair of laser diodes, are shown affixed to the mounting block 52. Each
light source emits a separate beam of light 20 toward a first collimating lens
58,
which gathers and collimates the light, and passes it to a spaced downstream
focusing lens 59, such that the beams of light are separately focused at focal
points 21, 21' on the surface plane. Again, although only two focal points are


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
shown, it is understood by reference to Figs. 7 and 8, that there will be at
least
four such focal points formed into the shape of a predetermined pattern on the
surface plane.
The device of Fig. 10 may be used with any conventional lens assembly,
5 such as that shown in Fig. 9, and comprising lens assembly 56. However, the
embodiment of light beam generation and focusing device 50 shown in Figs. 7-
10 may also be used with the micro-lens construction of the device shown in
Figs. 2-5, such that, and as shown in Fig. 11, a micro-lens 77 is affixed to
each
light source/laser diode 51 for gathering and collimating the respective light
10 beams, and passing the light beams to a spaced focusing lens 59, which then
passes the light beams to two separate focal points 21, 21'.
If full advantage of the construction shown in Figs. 2-5 is to be achieved,
then the construction of Fig. 12 results, in which each one of the light
sources
51 is provided with a compact lens assembly and casing as shown in Fig. 5,
15 such that the micro-lens is affixed directly to the laser diode, and a
casing is
also affixed to the laser diode, whereupon the focusing lens is affixed to the
casing so that no separate collimating and focusing lens assemblies are
needed for focusing and directing the separate beams of light 20 towards the
focal points 20, 21' on the surface plane.
In the embodiment of the light beam generation and focusing device
shown in Figs. 2-6, the construction of the device, namely there being a beam
steering device 28 provided as a part thereof, results in the sequential
direction
of a focused beam of light to at least two, and more preferably four, spaced
focal points 21 on the surface plane. In particular, for the embodiments of
the
device shown in Figs. 6A and 6B, a stepper motor and a focal plane 38 and/or
a prism 39 are used to steer the beam of light. As it necessary to physically
move the beam steering optical element 29 for directing the beam of light 20
to
any separate one of the different focal points 21, 21', and so on defined on
the
surface plane, the direction of the beam of light must necessarily be done in


CA 02377331 2001-12-18
WO 00/78242 PCT/L1S00/16576
16
sequence with a first focal point being established, and with any and all
subsequent focal points being established in sequential order.
For the embodiment of the device 15 shown in Fig. 6C, using the
holographic or diffractive optical element 40, and which does not otherwise
use
a drive motor as a part of the beam steering device, it is possible that the
beam
of light may be simultaneously directed to the several focal points formed on
the surface plane. If, however, and not illustrated but envisioned, the
holographic/diffractive element is used in combination with a beam steering
device positioned between the light source 16 and the downstream holographic
plate, then the focal points would be established sequentially, all as
desired,
and as programmed into the controller 27 of the device.
With regard to the embodiment of the device illustrated in Figs. 7-12,
however, still greater flexibility results from the construction of the device
in that
the controller 64 will preferably operate each of the four light sources/laser
diodes 51 sequentially for emitting separate beams of light from each
respective laser diode toward the surface plane. However, due to the
construction of the device shown in Figs. 7-12, it is also possible that the
controller 64 could be programmed so that each one of the light sources 51
fires simultaneously, although this is not preferred when compared to
sequential operation of the device in that the peak power drain on the battery
of the device would be much greater than from sequential operation. Also it is
possible that if all of the laser diodes of the device were operated
simultaneously the device would heat up more quickly, requiring a greater
cooling capacity for the mounting block 52, and there would likely be a
noticeable discomfort factor for the person on whose stratum corneum, for
example, the multiple light beams were focused as the surface plane.
Referring to Fig. 13, a control circuit 100 is shown which may be used to
operate either the stepper motor for the beam steering device 28 (Figs. 3A-4,
6A-6B) or to drive the multiple lasers in the embodiment shown in Figs. 7-12.
The control circuit 100 comprises a programmable controller 110, the power


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
17
switch 71 (referred to above), and a plurality of laser drive circuits 120. In
addition, the circuit 100 drives status indicators 130 and 132 (referred to
above) which are, for example, the bi-colored light emitting diodes (LEDs) 75.
Each laser drive circuit 120 comprises a field effect transistor (FET) 122
that
act as a high current switch to activate a corresponding one of the light
sources
51. The light sources 51 are, for example, laser diodes. A diode 124 is
included in each laser drive circuit 120 to provide protection for the light
sources 51 in the event a static discharge occurs. The parallel resistor-
capacitor combination in each laser drive circuit 120 acts as a filter for
pulse
smoothing and to reduce electrical switching spikes that may occur when the
control circuit 100 is powered on.
The controller 110 is, for example, a programmable micro-controller and
is programmed to time the on/off time signals coupled to the laser drive
circuits
120 for sequencing the operation of the light sources 51. For example, four of
the pins may be programmed to the proper sequence of time on vs. time off to
drive the drive (stepper) motor for the beam steering device 28.
Alternatively,
four of the pins may be programmed to the proper sequence of time on vs. time
off to power the field effect transistors which act as the high current
switches
used to turn the light source(s), here laser diodes, on and off in the desired
sequence. The outputs of the controller 110 that is coupled to the laser drive
circuits 120 are found at pins 11-14 thereof.
The signal on each of these pins is coupled to the gate of a FET 122 of
a corresponding laser drive circuit 120, and causes the desired time on vs.
time
off for a light source. The controller 110 also drives the status indicators
130
and 132 according to the status of the signals on pins 11-14. Programming of
the controller 110 is achieved by a suitable programming interface 112 that
supplies programming signals to pins 3 and 4 of the controller 110.
The controller 110 is also programmable to generate similar timing
signals at pins 11-14 to drive a stepper motor in the beam steering device 28
shown in Figs. 3A-4, 6A-6B, thereby controlling the location of the laser
beam.


CA 02377331 2001-12-18
WO 00/78242 PCT/US00/16576
18
Although, several embodiments of the invention have been disclosed in
the foregoing specification, it is understood by those skilled in the art that
many
modifications and other embodiments of the invention will come to mind to
which the invention pertains, having the benefit of the teaching presented in
the foregoing description and associated drawings. It is thus understood that
the invention is not limited to the specific embodiments disclosed herein, and
that many modifications and other embodiments of the invention are intended
to be included within the scope of the appended claims. Moreover, although
specific terms are employed herein, as well as in the claims, they are used in
the generic and descriptive sense only, and not for the purposes of limiting
the
described invention, nor the claims which follow.

Representative Drawing
A single figure which represents the drawing illustrating the invention.
Administrative Status

For a clearer understanding of the status of the application/patent presented on this page, the site Disclaimer , as well as the definitions for Patent , Administrative Status , Maintenance Fee  and Payment History  should be consulted.

Administrative Status

Title Date
Forecasted Issue Date Unavailable
(86) PCT Filing Date 2000-06-15
(87) PCT Publication Date 2000-12-28
(85) National Entry 2001-12-18
Dead Application 2006-06-15

Abandonment History

Abandonment Date Reason Reinstatement Date
2005-06-15 FAILURE TO PAY APPLICATION MAINTENANCE FEE
2005-06-15 FAILURE TO REQUEST EXAMINATION

Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Registration of a document - section 124 $100.00 2001-12-18
Application Fee $300.00 2001-12-18
Maintenance Fee - Application - New Act 2 2002-06-17 $100.00 2002-06-10
Maintenance Fee - Application - New Act 3 2003-06-16 $100.00 2003-04-08
Registration of a document - section 124 $50.00 2003-04-10
Registration of a document - section 124 $50.00 2003-04-10
Maintenance Fee - Application - New Act 4 2004-06-15 $100.00 2004-06-04
Owners on Record

Note: Records showing the ownership history in alphabetical order.

Current Owners on Record
ALTEA TECHNOLOGIES, INC.
SPECTRX, INC.
ALTEA THERAPEUTICS CORPORATION
Past Owners on Record
ALTEA DEVELOPMENT CORP.
EPPSTEIN, JONATHAN A.
HATCH, MICHAEL R.
KUMAR, KRISHNA
LINCOLN, DANNY F.
Past Owners that do not appear in the "Owners on Record" listing will appear in other documentation within the application.
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Document
Description 
Date
(yyyy-mm-dd) 
Number of pages   Size of Image (KB) 
Representative Drawing 2002-06-13 1 6
Description 2001-12-18 18 869
Cover Page 2002-06-14 1 48
Abstract 2001-12-18 1 72
Claims 2001-12-18 7 199
Drawings 2001-12-18 7 130
PCT 2001-12-18 13 537
Assignment 2001-12-18 3 92
Correspondence 2002-06-11 1 24
Assignment 2002-09-13 11 419
Correspondence 2002-09-13 1 38
Assignment 2003-04-10 14 428