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Patent 2392346 Summary

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(12) Patent: (11) CA 2392346
(54) English Title: GAMMA-RAY IMAGING
(54) French Title: IMAGERIE PAR RAYONS GAMMA
Status: Deemed expired
Bibliographic Data
(51) International Patent Classification (IPC):
  • G01T 1/29 (2006.01)
  • G01N 23/203 (2006.01)
(72) Inventors :
  • TICKNER, JAMES RICHARD (Australia)
(73) Owners :
  • COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (Australia)
(71) Applicants :
  • COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (Australia)
(74) Agent: BERESKIN & PARR LLP/S.E.N.C.R.L.,S.R.L.
(74) Associate agent:
(45) Issued: 2009-04-14
(86) PCT Filing Date: 2000-11-14
(87) Open to Public Inspection: 2001-05-25
Examination requested: 2005-09-22
Availability of licence: N/A
(25) Language of filing: English

Patent Cooperation Treaty (PCT): Yes
(86) PCT Filing Number: PCT/AU2000/001393
(87) International Publication Number: WO2001/036997
(85) National Entry: 2002-05-21

(30) Application Priority Data:
Application No. Country/Territory Date
PQ 4142 Australia 1999-11-18
PQ 4156 Australia 1999-11-19

Abstracts

English Abstract



The specification describes an instru-ment
and a method for determining information about
an object (J), only one side of which is available for
examination. The method involves exposing the
ob-ject to gamma-rays and measuring the position and/or
time of arrival of gamma-rays at a detector (D). The
instrument includes a source of gamma-rays (S)
lo-cated so that at least some gamma-rays impact upon
the object, and a detector surrounded by a shield (C)
having an aperture (A) for facing at the object to be
studied. The detector is capable of measuring the
po-sition and/or time of arrival at the detector of gamma-
rays passing through the aperture.


French Abstract

L'invention concerne un instrument et un procédé permettant de déterminer des informations relatives à un objet (J), dont un seul côté est disponible pour un examen. Ce procédé consiste à exposer ledit objet à des rayons gamma, et à mesurer la position et/ou le moment d'arrivée desdits rayons gamma au niveau d'un détecteur (D). L'instrument comprend une source de rayons gamma (S) située de sorte qu'au moins quelques rayons aient un impact sur l'objet, et un détecteur entouré d'une protection (C) possédant une ouverture (A) opposée à l'objet à étudier. Ledit détecteur peut mesurer la position et/ou le moment d'arrivée, au niveau du détecteur, des rayons gamma qui traversent l'ouverture.

Claims

Note: Claims are shown in the official language in which they were submitted.




-8-


THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:

1. An instrument for obtaining 2-dimensional
information about the distribution of mass of an object,
the instrument including;
a source of positrons, shielded so that the
positrons annihilate and produce co-linear gamma-rays
pairs in the immediate vicinity of the source, said source
being located with respect to an object to be examined
that at least some of the gamma-rays impinge on the
object;
a gamma-ray shield surrounding a gamma-ray
detector having an aperture for facing at the object to be
examined, said gamma-ray detector being located on the
same side of the object as the source of positrons, and
said gamma-ray detector being capable of detecting the
arrival position of gamma-rays of said gamma-ray pairs
travelling directly from the source and the arrival
position of gamma-rays of said gamma-ray pairs after
scattering from the object and passing through said
aperture; and
means for determining 2-dimensional information
about the object from the direction of flight of the
directly detected gamma-ray and the arrival position of
the scattered gamma-ray of each gamma-ray pair.

2. An instrument for obtaining 2-dimensional
information about the distribution of mass of an object,
the instrument including:
a source of gamma-rays so located with respect to
an object to be examined that at least some of the gamma-
rays impinge on the object;
a gamma ray shield surrounding a gamma-ray
detector having an aperture for facing at the object to be
examined said aperture being sufficiently small to project
an image of the object onto said detector, said gamma-ray
detector being located on the same side of the object as



-9-

the source of gamma-rays and being capable of detecting
the arrival position of gamma-rays scattered from the
object and passing through the aperture; and
means for determining 2-dimensional information
about the object derived from the detected positions of
scattered gamma-rays.

3. An instrument for obtaining 1-dimensional
information about the distribution of mass of an object,
the instrument including:
a source of gamma-rays, said source being so
located with respect to an object to be examined that at
least some of the gamma-rays impinge on the object;
a gamma-ray shield surrounding one or more
detectors having an aperture for facing at the object to
be examined;
a detector located on the same side of the object
as said source, said detector being capable of determining
the arrival time of gamma-rays having scattered from the
object and inferring the departure time of said gamma-rays
from said source; and
means for determining 1-dimensional information
about the object from the arrival times of said scattered
gamma-rays and said inferred departure times of said
gamma-rays.
4. An instrument as claimed in claim 1 or claim 2,
wherein said gamma-ray detector is also capable of
detecting the time of arrival of said gamma-rays, whereby
the difference in arrival times between the scattered
gamma-ray at the detector and its inferred departure time
from the source is used to additionally infer the distance
of penetration of the scattering gamma-ray into the
object, whereby 3-dimensional information about the
distribution of mass of an object can be obtained.

5. An instrument as claimed in claim 3 or claim 4,


10
wherein the departure time of said scattered gamma-ray is
inferred from the detection of a gamma-ray travelling
directly from said source.

6. An instrument as claimed in any one of claims 1
to 5, wherein said instrument includes two or more
detectors and separate detectors are used to detect
scattered gamma-rays and directly arriving gamma-rays.

7. An instrument as claimed in any one of claims 1
to 6, wherein the detector consists of one or more slabs
of a scintillator material which are read out by a
multiplicity of light detectors.

8. An instrument according to claim 7, wherein the
light detectors are photomultipliers or semi-conductor
diodes having a fast response time.

9. An instrument according to any one of claims 1 to
8, wherein a digital processing system is used to
calculate and tabulate the inferred gamma-ray scattering
positions within the object from the arrival positions
and/or times of the detected gamma-rays.

10. An instrument according to claim 9, wherein said
digital processing system is used to calculate the
distribution of mass within the object being examined from
the tabulated gamma-ray scattering positions.

11. A method for obtaining 2-dimensional information
about the distribution of mass of an object, the method
including:
generating co-linear gamma-ray pairs using a
position source;
causing at least some of the gamma-rays to impact
on an object and undergo scattering;
detecting the position of arrival of a gamma-ray pair
incident upon a detector located on the same side of the
object as said source the gamma-ray pair comprising a


-10a-
gamma-ray travelling directly from the source and a gamma-
ray scattered by the object; and
determining 2-dimensional information about the
object from the direction of flight of the directly
detected gamma-ray and the arrival position of the
scattered gamma-ray of each gamma-ray pair.

12. A method for obtaining 2-dimensional information
about the distribution of a mass of an object, the method
including:
generating gamma-rays using a gamma-ray source;
causing at least some of the gamma-rays to impact
on an object;
shielding a detector located on the same side of
the object as said gamma-ray source with a shield having a
aperture having a size sufficiently small enough to
project an image of the object onto said detector;
detecting the position of each gamma-ray
scattered from the object incident upon said detector; and
determining 2-dimensional information about the
object from the detected position of the scattered gamma-
rays.

13. A method for obtaining 1-dimensional information
about the distribution of mass of an object, the method
including:
generating gamma-rays using a gamma-ray source;
causing at least some of the gamma-rays to impact
on an object;
shielding a detector located on the same side of
the object as the source with a gamma-ray shield having an
aperture facing the object to be examined;
determining the arrival times at said detector of
gamma-rays having scattered from said object;
inferring departure times of said to be scattered
gamma-rays from said source; and
determining 1-dimensional information about the
object from the arrival times of said scattered gamma-rays
and the inferred departure times of said to be scattered
gamma-rays.


-10b-

14. A method as claimed in claim 11 or claim 12,
further including detecting the time of arrival of each
gamma-ray, whereby the difference in arrival times between
the scattered gamma-ray and its inferred departure time
from the source is used to additionally infer the distance
of penetration of the scattering gamma-ray into the object
whereby 3-dimensional information about the distribution
of mass of an object can be obtained.

15. A method as claimed in claim 13 or claim 14,
wherein inferring departure times of said to be scattered
gamma-rays involves determining arrival times of gamma-
rays travelling directly from said source.

16. A method as claimed in any one of claims 11 to
15, involving detecting scattered 9amma-rays and directly
arriving gamma-rays using separate detectors.

Description

Note: Descriptions are shown in the official language in which they were submitted.



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G11MA-RAY INAGING
TeChnical Field
The inventioa relates to the use of gamma-rays to
produce an image of an object. In particular, the invention
is useful in applications where a 1, 2 or 3-dimensional
image is required and there is access to only one side of
the object.

Background Art
Gamma-rays are widely used to produce images of
extended objects, for example for medical diagnoses. When
there is access to both sides of the object being studied,
the conventional approach is to measure the attenuation of
a gamma-ray beam passing through the object from a source
on one side of the object to a detector on the other. If a
wide area beam is used together with a position sensitive
detector, a two dimensional map of the object is produced.
To produce a 3-dimensional image, multiple two dimensional
slices can be combined using computed tomography (CT)
techniques. If the object being studied can be injected
with a positron emitting nuclide, positron emission
tomography (PET) can be used to build up a 3-dimensional
image of the object by using the back-to-back 511 keV
gamma-rays produced when the positron annihilates.
Throughout the specification the term gamma-ray
means electromagnetic photons having an energy of about 1
keV or more and includes electromagnetic photons normally
known as X-rays which range up to about 100 keV.
When there is access to only one side of the
object being studied, techniques based on gamma-ray
transmission are impossible. Compton scatter imaging (CSI)
has been proposed as an alternative method. Gamma-rays from
a source pass into the object being studied, undergo a
Ccaqpton scatter back out of the object and are counted
using a suitable detector. Because there is a close
relationship between the angle that the qamma-ray scatters


CA 02392346 2002-05-21

WO 01/36997 PCT/AUOO/01393
-a-
throuQh and the energy that it loses, by measuring the
energy spectrum of the scattered gamma-rays it is possible
to infer the distribution of material within the object of
interest. However, unfolding this distribution requires
complicated mathematical deconvolution techniques.
Alternatively, if a collimated gamma-ray beam is used and
the direction of the scattered gamma-rays is determined,
direct imaging is possible. However, such systems typically
have fairly low efficiencies and scanning is required to
build up a full 3-dimensional image.
If the object being studied produces gamaa-rays
itself (examples would include a biological specimen
injected with a radiological tracer or a distant
astronomical image), a 2-dimensional image of the
radioactive source density can be produced using an Anger
camera or a Compton telescope. The former uses a position
sensitive gamma-ray detector together with a gamma-ray
opaque screen with a small aperture that projects an image
of the object being studied onto the detector. Large or
multiple apertures can be used to increase the efficiency
of the camera, but necessitate the use of mathematical
deconvolution techniques to form an image. The Compton
telescope makes use of the angle/energy relationship of the
Compton scattering process described above to infer the
direction of an incident gamma-ray by measuring its
interaction with two separate position sensitive detectors.
The Conpton telescope can be fairly efficient, but again
mathematical deconvolution is required to obtain an image.
All of these methods suffer from one or more of
the following disadvantages:
= Access is required to 2 or more sides of the object
being studied;
a Only 2-dimensional information is obtained;
+ The object being studied needs to contain radioactive
nuclei;
0 Complex mathematical techniques are required to produce
an image of the object;


CA 02392346 2002-05-21
M.

PCT/AU00/01393
Received 31 August 2001
- 3 -

= Scanning of the object and/or source/detector are
required to build up an image.

Summary of the Invention
In a first aspect, the invention provides an
instrument for obtaining 2-dimensional information about
the distribution of mass of an object, the instrument
including;
a source of positrons, shielded so that the
positrons annihilate and produce co-linear gamma-rays
pairs in the immediate vicinity of the source, said source
being located with respect to an object to be examined
that at least some of the gamma-rays inpinge on the
object;
a gamma-ray shield surrounding a gamma-ray
detector having an aperture for facing at the object to be
examined, said gamma-ray detector being located on the
same side of the object as the source of positrons, and
said gamma-ray detector being capable of detecting the
arrival position of gamma-rays of said gamma-ray pairs
travelling directly from the source and the arrival
position of gamma-rays of said gamma-ray pairs after
scattering from the object and passing through said
aperture; and
means for determining 2-dimensional information
about the object from the direction of flight of the
directly detected gamma-ray and the arrival position of
the scattered gamma-ray of each gamma-ray pair.
In a second aspect, the invention provides an
instrument for obtaining 2-dimensional information about
the distribution of mass of an object, the instrument
including:
a source of gamma-rays so located with respect to
an object to be examined that at least some of the gamma-
rays impinge on the object;
a gamma ray shield surrounding a gamma-ray
detector having an aperture for facing at the object to be

õ:~Innel\KerP\~~\ICT-AUOU-U13o).dOC !IlDNlDI


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Received 31 August 2001
- 4 -

examined said aperture being sufficiently small to project
an image of the object onto aaid detector, said gamma-ray
detector being located on the same side of the object as
the source of Qamma-raya and being capable of detecting
the arrival position of gamma-rays scattered from the
object and passing through the aperture; and
means for determining 2-dimensional information
about the object derived from the detected positions of
scattered gamma-rays.
In a third aspect, the invention provides an
instrument for obtaining 1-dimensional information about
the distribution of mass of an object, the instrument
including:
a source of Qamma-rays, said source being so
located with respect to an object to be examined that at
least some of the gamma-rays impinge on the object;
a gamma-ray shield surrounding one or more
detectors having an aperture for facing at the object to
be examined;
a detector located on the same aide of the object
as said source, said detector being capable of determining
the arrival time of gamma-raya having scattered from the
- object and inferring the departure time of said gamma-rays
from said source; and
means for determining 1-dimensional information
about the object from the arrival times of said scattered
gamma-rays and said inferred departure times of said
gamma-rays.
In a fourth aspect, the invention provides a
method for obtaining 2-dimensional information about the
distribution of mass of an object, the method including:
generating co-linear gamma-ray pairs using a
position source;
causing at least some of the gamma-rays to impact
on an object;
detecting the position of arrival of each gamma-
ray pair incident upon a detector located on the same side

Ho\].,nellKeep\CPe^-i \FCT-AUDO01)9).doc )1/08/OI


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PCTlAU00/01393
Received 31 August 2001
- 4a -

of the object as said source; and
determining 2-dimensional information about the
object from the direction of flight of the directly
detected Qamma-ray and the arrival position of the
scattered gamma-ray of each gamma-ray pair.
In a fifth aspect, the invention provides a
method for obtaining 2-dimensional information about the
distribution of a mass of an object, the method including:
generating Qamma-raya using a Qamma-ray source;
causing at least some of the gamma-rays to impact
on an object;
shielding a detector located on the same side of
the object as said gamma-ray source with a shield having a
aperture having a size sufficiently small enough to
project an image of the object onto said detector;
detecting the position of each gamma-ray
scattered from the object incident upon said detector; and
determining 2-dimensional information about the
object from the detected position of the scattered Qamma-
rays.
In a sixth aspect, the invention provides a
method for obtaining 1-dimensional information about the
distribution of mass of an object, the method including:
generating gamma-rays using a gamma-ray source;
causing at least some of the gamma-rays to impact
on an object;
determining the arrival times at said detector of
gamma-rays having scattered from said object;
inferring departure times of said to be scattered
gamma-rays from said source; and
determining 1-dimensional information about the
object from the arrival times of said scattered gamma-rays
and the inferred departure times of said to be scattered
Qamma-rays.
Brief Description of the Drawings
Figure 1 is a schematic drawing of a preferred

N-`=7.ne7~Keep\SP?'~~'~T-nua0-U1]9l.doc 31/06/01


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PCT/AU00/01393
Received 31 August 2001
- 4b -

embodiment of the invention;
Figure 2 is a schematic drawing of a second
embodiment of the invention;
Figure 3 is a schematic drawing of a third
embodiment of the invention; and
Figure 4 is a schematic drawing of another
embodiment of the invention.

Detailed Description of the Drawings
Figure 1 shows: (i) a gamma-ray detector (D)
which is instrumented to provide the position and time of
an incident gamma-ray; (ii) a collimator (C) made of lead
or another suitable gamma-ray shielding material
containing an aperture (A) in its front face and (iii) a
positron source (5) surrounded by sufficient shielding
material that positrons emitted by the source are brought
to rest and annihilate in the vicinity of the source.
The operation of the embodiment is as follows. A
positron from the source (S) comes to rest in the
shielding surrounding the source and annihilates,
producing two 511 keV gamma-rays travelling back-to-back.
One of the gamma-rays (1) is detected in detector (D) and
the time and position of its arrival noted. The other
gamma-ray (2) enters the object being examined (J) and
scatters at some point (P) within the object. The
scattered gamma-ray is then detected in detector (D) and
its position and time of

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WO 01/36997 PCT/AUOO/01393
- 5 -

arrival noted. The positions of the two gamma-rays in
detector (D) and the time between their arrival suffices to
calculate the scattering position (P). By measuring gamma-
rays from a large number of positron annihilation events, a
profile of the probability of scattering and hence the
electron-density inside the object (J) can be determined.
The electron density in turn can be approximately related
to the physical density of matter inside the object.
Figure 2 depicts a gamma-ray source (S) producing
2 or more coincident gamma-rays, gamma-ray detectors (D and
D'), and a collimator (C) containing an aperture (A).
Gamma-ray (1) is detected in (D') travelling directly from
the source and gamma-ray (2) is detected in (D) after
scattering at point (P) in the object being studied (J).
Gamma-ray detector (D') can be omitted, with both gamma-
rays being detected in detector (D).
Figure 3 depicts a gamma-ray source (S), gamma-
ray detector (D), and a collimator (C) containing an
aperture (A). Gamma-rays are detected in (D) after
scattering at point (P) in the object being studied (J).
Figure 4 depicts a gamma-ray or positron source
(S) producing 2 or more coincident gamma-rays, gamma-ray
detectors (D and D'), and a collimator (C) containing an
aperture (A). One gamma-ray is detected directly in
detector (D) or (D') if used; the other gamma-ray is
detected in (D) after scattering at point (P) in the object
being studied (J). Gamma-ray detector (D') can be omitted,
with both gamma-rays being detected in detector (D).

Modes for Carrying out the Invention
The physical dimensions and construction of the
embodiments depend on the spatial resolution that is
required when mapping the density of object (J) and the
field of view required.
Detector (D) may comprise one or more slabs of a
scintillator material having a fast light decay time. The
slab(s) are read out by a multiplicity of light detectors


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- 6 -

such as photomultiplier tubes or semiconductor diodes.
Timing and possibly amplitude information from these
detectors may be used to determine the position and arrival
time of an incident gamma-ray. It will be appreciated that
this description represents only one possible realisation
of detector (D) and other detectors designs could be used
without affecting the underlying nature of the invention.
The collimator (C) should be sufficiently opaque
to gamma-rays to shield the detector (D) from gamma-rays
scattered from the object (J), other than those gamma-rays
passing through aperture (A). The size and form of aperture
(A) should be chosen to optimise the spatial resolution and
efficiency of the invention.
The following variations on the first embodiment
are also included:
1. A gamma-ray imaging device as per the first
embodiment, with the positron source (S) replaced by a
gamma-ray source which produces at least two coincident
gamma-rays per decay. One gamma-ray is detected in detector
(D) or in a small detector (D') immediately surrounding the
source (S) and its time of arrival noted. The other gamma
ray scatters from the object (J) and its time and arrival
in detector (D) noted. Aperture (A) is made small enough
that scattered gamma-rays project an image of object (J)
onto detector (D). From the position of the scattered
gamma-ray in detector (D) and the time between its arrival
and the arrival of the directly detected gamma-ray, the
scattering position (P) and hence the density profile of
the object (J) can be determined. By selecting a source
producing gamma-rays of suitable energy, the penetration of
the imaging device into object (J) can be controlled.
2. A gamma-ray imaging device as per the second
embodiment, with the source (S) replaced by a gamma-ray
source where only one gamma-ray per decay is used. No
timing information is measured or used. Such a device would
permit a 2-dimensional map of the density of object (J) to
be determined, with the density profile over the third


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- 7 -

coordinate (radial distance from the source (S)) being
averaged.
3. A gamma-ray profiling device as per the first
embodiment, with the arrival position of the two gamma-rays
in detector (D) not being measured or used. The difference
between the arrival times of the two gamma-rays is used to
determine the density profile of object (J) in 1-dimension
(radial distance from the source (S)). The source (S) can
either comprise a positron emitting source as in the main
invention, or a source producing two coincident gamvaa-rays
as per variation 1 above; in this instance, one of the
ganrma-rays may be detected in a amall detector (D')
surrounding the source. Collimator (C) and aperture (A) can
be adjusted to control the transverse size of the region of
object (J) that is examined.
Figures 2, 3 and 4 illustrate these variations.
Other minor variations, within the spirit of the main
invention and the variations described above, are also
included within the scope of the invention.
Industrial Applicability
The invention has utility in the following
applications:
1.Detection of buried landmines, relying on the fact that
mines have a different density from the surrounding
soil.
2.Detection of other buried objects having dimensions a
few cm or larger.
3.Non-invasive measurement of refractory linings inside
burners or furnaces.
4.Non-invasive measurement of the build up of
deposits/scale inside pipelines.
5.Non-invasive measurement of density of materials flowing
inside pipelines.
Other uses of the invention are also conceivable.

Representative Drawing
A single figure which represents the drawing illustrating the invention.
Administrative Status

For a clearer understanding of the status of the application/patent presented on this page, the site Disclaimer , as well as the definitions for Patent , Administrative Status , Maintenance Fee  and Payment History  should be consulted.

Administrative Status

Title Date
Forecasted Issue Date 2009-04-14
(86) PCT Filing Date 2000-11-14
(87) PCT Publication Date 2001-05-25
(85) National Entry 2002-05-21
Examination Requested 2005-09-22
(45) Issued 2009-04-14
Deemed Expired 2011-11-14

Abandonment History

There is no abandonment history.

Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Application Fee $300.00 2002-05-21
Maintenance Fee - Application - New Act 2 2002-11-14 $100.00 2002-05-21
Registration of a document - section 124 $100.00 2003-07-24
Maintenance Fee - Application - New Act 3 2003-11-14 $100.00 2003-10-22
Maintenance Fee - Application - New Act 4 2004-11-15 $100.00 2004-10-20
Request for Examination $800.00 2005-09-22
Maintenance Fee - Application - New Act 5 2005-11-14 $200.00 2005-10-18
Maintenance Fee - Application - New Act 6 2006-11-14 $200.00 2006-10-17
Maintenance Fee - Application - New Act 7 2007-11-14 $200.00 2007-10-17
Maintenance Fee - Application - New Act 8 2008-11-14 $200.00 2008-10-27
Final Fee $300.00 2009-02-02
Maintenance Fee - Patent - New Act 9 2009-11-16 $200.00 2009-10-14
Owners on Record

Note: Records showing the ownership history in alphabetical order.

Current Owners on Record
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Past Owners on Record
TICKNER, JAMES RICHARD
Past Owners that do not appear in the "Owners on Record" listing will appear in other documentation within the application.
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Document
Description 
Date
(yyyy-mm-dd) 
Number of pages   Size of Image (KB) 
Claims 2007-10-31 5 194
Representative Drawing 2002-05-21 1 137
Abstract 2002-05-21 1 65
Claims 2002-05-21 5 191
Drawings 2002-05-21 4 198
Description 2002-05-21 9 389
Cover Page 2002-11-07 1 112
Representative Drawing 2009-03-27 1 34
Cover Page 2009-03-27 1 62
Assignment 2002-05-21 3 91
PCT 2002-05-21 13 480
Correspondence 2002-11-05 1 24
Assignment 2003-07-24 2 67
Prosecution-Amendment 2005-09-22 1 29
Prosecution-Amendment 2006-01-04 1 32
Prosecution-Amendment 2007-05-03 3 109
Prosecution-Amendment 2007-10-31 4 136
Correspondence 2009-02-02 1 29