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CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
Nucleic Acids, Proteins, and Antibodies
[1] This application refers to a "Sequence Listing" that is provided only on
electronic
media in computer readable form pursuant to Administrative W structions
Section 801(a)(i).
The Sequence Listing forms a part of this description pursuant to Rule 5.2 and
Administrative Instructions Sections 801 to 806, and is hereby incorporated in
its entirety.
[2] The Sequence Listing is provided as an electronic file (PJZ06 seqList.txt,
1,912,263 bytes in size, created on January 13, 2001) on four identical
compact discs (CD-
R), labeled "COPY l," "COPY 2," "COPY 3," and "CRF." The Sequence Listing
complies
with Annex C of the Administrative Instructions, and may be viewed, for
example, on an
IBM-PC machine- running the MS-Windows operating system by using the V viewer
software, version 2000 (see World Wide Web URL: http://www.fileviewer.corn).
Field of the hzvehtioh
[3] The present invention relates to novel proteins. More specifically,
isolated nucleic
acid molecules are provided encoding novel polypeptides. Novel polypeptides
and antibodies
that bind to these polypeptides are provided. Also provided are vectors, host
cells, and
recombinant and synthetic methods for producing human polynucleotides and/or
polypeptides, and antibodies. The invention further relates to diagnostic and
therapeutic
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CA 02395858 2002-06-21
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methods useful for diagnosing, treating, preventing and/or prognosing
disorders related to
these novel polypeptides. The invention further relates to screening methods
for identifying
agonists and antagonists of polynucleotides and polypeptides of the invention.
The present
invention further relates to methods and/or compositions for inhibiting or
enhancing the
production and function of the polypeptides of the present invention.
Background of the Invention
[4] Inflammation, which is characterized by redness, swelling, heat, and pain,
is an
essential immune response which occurs following tissue injury or infection.
The initial
stimulus (i.e injury, infection) triggers the release of pro-inflammatory
proteins, including
histamine, prostaglandins, kinins, leukotrienes, and cytokines, which mediate
increased local
blood flow, blood clotting, vascular permeability, and leukocyte
chemoattraction. As a result
of these changes, plasma components such as complement proteins, clotting
factors,
fibrinogen, and antibody proteins accumulate in the injured or infected
tissue. The acute
changes also facilitate the recruitment of phagocytic leukocytes to the site
of injury or
infection. Chemokines released from the site of inflammation mediate leukocyte
recruitment,
in part by inducing the expression of cell adhesion molecules on activated
monocytes and
neutrophils Once at the affected site, plasma proteins and immune cells begin
to neutralize
pathogens and contribute to tissue repair.
[5] In most cases, inflammation leads to the resolution of the infection or
injury,
followed by termination of the inflammatory response. However, in some cases a
sustained
inflammatory response persists. Chronic inflammation can occur when an
invading organism
has not been eliminated, such as in untreated tuberculosis and leprosy, or
when an
endogenous protein becomes immunogenic, resulting in autoimmune disorders.
Inappropriate or excessive activation of inflammation can lead to tissue
damage and even
death.
[6] Inflammation can effect virtually any tissue of the body, and plays an
important
role in many diseases, including infections (e.g. pneumonia, Legionnaires'
disease,
tuberculosis, meningitis, encephalitis, viral hepatitis and septic shock),
hypersensitivities
(e.g., allergic rhinitis, skin allergies, anaphylaxis and asthma), and
autoimmune disorders
(e.g. multiple sclerosis, rheumatoid arthritis, myasthenia gravis,
myocarditis; and vasculitis,
to name but a few).
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[7] Inflammation can also be a life-threatening complication of severe
physical trauma
(e.g. traumatic head injury), burns, cardiopulmonary bypass surgery, renal
ischemia-
reperfusion, and organ transplant surgery.
[8] Furthermore, chronic inflammation increases the rislc of cancer (Wiseman
and
Halliwell, Biochem. J. 313:17-29 (1996). For example, patients with
inflammatory bowel
disease are at higher risk of developing gastrointestinal cancer (Lewis et
al., Gastroenterol.
Clin. North Amer. 28(2):459-77 (1999)), while lung cancer has been linked to
chemical-
induced lung inflammation (Emmendoerffer et aL, Toxicol. Lett. 112-113: 185-
191 (2000)).
[9] Many of the physiological correlates of inflammation are mediated by the
hormonal actions of prostaglandins, a class of cyclic unsaturated fatty acids
that are
converted from arachidonic acid by cyclooxygenase. Attempts to ameliorate the
symptoms
of inflammation center around decreasing prostaglandin production by
inhibiting the key
synthetic enzymes, cyclooxygenase and phopholipase A2. Steroidal drugs such as
prednisone and cortisone, and non-steroidal drugs such as aspirin and
ibuprofen, are
frequently used to treat the symptoms of inflammation. However, these
therapies are
accompanied by side effects, ranging from stomach irritation to osteoporosis,
which limit
their usefulness. Therefore, there is a continuing need for more effective and
less toxic
alternatives for modulating the inflammatory response.
[10] The discovery of new human inflammation-associated polynucleotides, the
polypeptides encoded by them, and antibodies that immunospecifically bind
these
polypeptides, satisfies a need in the art by providing new compositions which
are useful in
the diagnosis, treatment, prevention and/or prognosis of inflammatory
diseases, disorders,
and/or conditions, including, but not limited to, viral, bacterial, fungal,
and parasitic
infections; hypersensitivities; autoimmune disorders; physical trauma; organ
transplant
rejection; and cancer.
Summary of the Invention
[1l] The present invention relates to novel proteins. More specifically,
isolated nucleic
acid molecules are provided encoding novel polypeptides. Novel polypeptides
and antibodies
that bind to these polypeptides are provided. Also provided are vectors, host
cells, and
recombinant and synthetic methods for producing human polynucleotides and/or
polypeptides, and antibodies. The invention further relates to diagnostic and
therapeutic
methods useful for diagnosing, treating, preventing and/or prognosing
disorders related to
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these novel polypeptides. The invention further relates to screening methods
for identifying
agonists and antagonists of polynucleotides and polypeptides of the invention.
The present
invention further relates to methods and/or compositions for inhibiting or
enhancing the
production and function of the polypeptides of the present invention.
Detailed Description
Tables
[12] Table 1A summarizes some of the polynucleotides encompassed by the
invention
(including cDNA clones related to the sequences (Clone ID NO:Z), contig
sequences (contig
identifier (Contig ID:) and contig nucleotide sequence identifier (SEQ ID
NO:X)) and further
summarizes certain characteristics of these polynucleotides and the
polypeptides encoded
thereby. The first column provides the gene number in the application for each
clone
identifier. The second column provides a unique clone identifier, "Clone ID
NO:Z", for a
cDNA clone related to each contig sequence disclosed in Table 1A. The third
column
provides a unique contig identifier, "Contig ID:" for each of the contig
equences disclosed
in Table 1A. The fourth column provides the sequence identifier, "SEQ ID
NO:X", for each
of the contig sequences disclosed in Table 1A. The fifth column, "ORF (From-
To)",
provides the location (i.e., nucleotide position numbers) within the
polynucleotide sequence
of SEQ ID NO:X that delineate the preferred open reading frame (ORF) that
encodes the
amino acid sequence shown in the sequence listing and referenced in Table 1A
as SEQ ID
NO:Y (column 6). Column 7 lists residues comprising predicted epitopes
contained in the
polypeptides encoded by each of the preferred ORFs (SEQ ID NO:Y).
Identification of
potential immunogenic regions was performed according to the method of Jameson
and Wolf
(CABIOS, 4; 181-186 (1988)); specifically, the Genetics Computer Group (GCG)
implementation of this algorithm, embodied in the program PEPTIDESTRUCTURE
(Wisconsin Package v10.0, Genetics Computer Group (GCG), Madison, Wisc.). This
method
returns a measure of the probability that a given residue is found on the
surface of the protein.
Regions where the antigenic index score is greater than 0.9 over at least 6
amino acids are
indicated in Table 1A as "Predicted Epitopes". In particular embodiments,
polypeptides of
the invention comprise, or alternatively consist of, one, two, three, four,
five or more of the
predicted epitopes described in Table 1A. It will be appreciated that
depending on the
analytical criteria used to predict antigenic determinants, the exact address
of the determinant
may vary slightly. Column 8, "Tissue Distribution" shows the expression
profile of tissue,
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cells, and/or cell line libraries which express the polynucleotides of the
invention. The first
number in column 8 (preceding the colon), represents the tissue/cell source
identifier code
corresponding to the key provided in Table 4. Expression of these
polynucleotides was not
observed in the other tissues and/or cell libraries tested. For those
identifier codes in which
the first two letters are not "AR", the second number in column 8 (following
the colon),
represents the number of times a sequence corresponding to the reference
polynucleotide
sequence (e.g., SEQ ID NO:X) was identified in the tissue/cell source. Those
tissue/cell
source identifier codes in which the first two letters are "AR" designate
information
generated using DNA array technology. Utilizing this technology, cDNAs were
amplified by
PCR and then transferred, in duplicate, onto the array. Gene expression was
assayed through
hybridization of first strand cDNA probes to the DNA array. cDNA probes were
generated
from total RNA extracted from a variety of different tissues and cell lines.
Probe synthesis
was performed in the presence of 33P dCTP, using oligo(dT) to prime reverse
transcription.
After hybridization, high stringency washing conditions were employed to
remove non-
specific hybrids from the array. The remaining signal, emanating from each
gene target, was
measured using a Phosphorimager. Gene expression was reported as Phosphor
Stimulating
Luminescence (PSL) which reflects the level of phosphor signal generated from
the probe
hybridized to each of the gene targets represented on the array. A local
background signal
subtraction was performed before the total signal generated from each array
was used to
normalize gene expression between the different hybridizations. The value
presented after
"[array code]:" represents the mean of the duplicate values, following
background subtraction
and probe normalization. One of skill in the art could routinely use this
information to
identify normal and/or diseased tissues) which show a predominant expression
pattern of the
corresponding polynucleotide of the invention or to identify polynucleotides
which show
predominant and/or specific tissue and/or cell expression. Column 9 provides
the
chromosomal location of polynucleotides corresponding to SEQ ID NO:X.
Chromosomal
location was determined by finding exact matches to EST and cDNA sequences
contained in
the NCBI (National Center for Biotechnology Information) UniGene database.
Given a
presumptive chromosomal location, disease locus association was determined by
comparison
with the Morbid Map, derived from Online Mendelian Inheritance in Man (Online
Mendelian
Inheritance in Man, OMIMTM. McI~usick-Nathans Institute for Genetic Medicine,
Johns
Hopkins University (Baltimore, MD) and National Center for Biotechnology
Information,
National Library of Medicine (Bethesda, MD) 2000. World Wide Web URL:
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
http://www.ncbi.nlm.nih.gov/omim/). If the putative chromosomal location of
the Query
overlaps with the chromosomal location of a Morbid Map entry, an OMIM
identification
number is disclosed in column 10 labeled "OMIM Disease References)". A key to
the
OMIM reference identification numbers is provided in Table 5.
[13] Table 1B summarizes additional polynucleotides encompassed by the
invention
(including cDNA clones related to the sequences (Clone ID NO:Z), contig
sequences (contig
identifier (Contig ID:) contig nucleotide sequence identifiers (SEQ ID NO:X)),
and genomic
sequences (SEQ ID NO:B). The first column provides a unique clone identifier,
"Clone ID
NO:Z", for a cDNA clone related to each contig sequence. The second column
provides the
sequence identifier, "SEQ ID NO:X", for each contig sequence. The third column
provides a
unique contig identifier, "Contig ID:" for each contig sequence. The fourth
column, provides
a BAC identifier "BAC ID NO:A" for the BAC clone referenced in the
corresponding row of
the table. The fifth column provides the nucleotide sequence identifier, "SEQ
ID NO:B" for
a fragment of the BAC clone identified in column four of the corresponding row
of the table.
The sixth column, "Exon From-To", provides the location (i.e., nucleotide
position numbers)
within the polynucleotide sequence of SEQ ID NO:B which delineate certain
polynucleotides
of the invention that are also exemplary members of polynucleotide sequences
that encode
polypeptides of the invention (e.g., polypeptides containing amino acid
sequences encoded
by the polynucleotide sequences delineated in column six, and fragments and
variants
thereof).
[14] Table 2 summarizes homology and features of some of the polypeptides of
the
invention. The first column provides a unique clone identifier, "Clone ID
NO:Z",
corresponding to a cDNA clone disclosed in Table 1A. The second column
provides the
unique contig identifier, "Contig ID:" corresponding to contigs in Table 1A
and allowing for
correlation with the information in Table 1A. The third column provides the
sequence
identifier, "SEQ ID NO:X", for the contig polynucleotide sequence. The fourth
column
provides the analysis method by which the homology/identity disclosed in the
Table was
determined. Comparisons were made between polypeptides encoded by the
polynucleotides
of the invention and either a non-redundant protein database (herein referred
to as "NR"), or
a database of protein families (herein referred to as "PFAM") as further
described below.
The fifth column provides a description of the PFAM/NR hit having a
significant match to a
polypeptide of the invention. Column six provides the accession number of the
PFAM/NR
hit disclosed in the fifth column. Column seven, "Score/Percent Identity",
provides a quality
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score or the percent identity, of the hit disclosed in columns five and six.
Columns 8 and 9,
"NT From" and "NT To" respectively, delineate the polynucleotides in "SEQ ID
NO:X" that
encode a polypeptide having a significant match to the PFAM/NR database as
disclosed in
the fifth and sixth columns. In specific embodiments polypeptides of the
invention comprise,
or alternatively consist of, an amino acid sequence encoded by a
polynucleotide in SEQ ID
NO:X as delineated in columns 8 and 9, or fragments or variants thereof.
[15] Table 3 provides polynucleotide sequences that may be disclaimed
according to
certain embodiments of the invention. The first column provides a unique clone
identifier,
"Clone ID", for a cDNA clone related to contig sequences disclosed in Table
1A. The
second column provides the sequence identifier, "SEQ ID NO:X", for contig
sequences
disclosed in Table 1A. The third colmnn provides the unique contig identifier,
"Contig ID:",
for contigs disclosed in Table 1A. The fourth column provides a unique integer
'a' where 'a'
is any integer between 1 and the final nucleotide minus 15 of SEQ ID NO:X, and
the fifth
column provides a unique integer 'b' where 'b' is any integer between 15 and
the final
nucleotide of SEQ ID NO:X, where both a and b correspond to the positions of
nucleotide
residues shown in SEQ ID NO:X, and where b is greater than or equal to a + 14.
For each of
the polynucleotides shown as SEQ ID NO:X, the'uniquely defined integers can be
substituted
into the general formula of a-b, and used to describe polynucleotides which
may be
preferably excluded from the invention. In certain embodiments, preferably
excluded from
the invention are at least one, two, three, four, five, ten, or more of the
polynucleotide
sequences) having the accession numbers) disclosed in the sixth column of this
Table
(including for example, published sequence in connection with a particular BAC
clone). In
further embodiments, preferably excluded from the invention are the specific
polynucleotide
sequences) contained in the clones corresponding to at least one, two, three,
four, five, ten,
or more of the available material having the accession numbers identified in
the sixth column
of this Table (including for example, the actual sequence contained in an
identified BAC
clone).
[16] Table 4 provides a key to the tissue/cell source identifier code
disclosed in Table
1A, column 8. Column 1 provides the tissuelcell source identifier code
disclosed in Table 1A,
Column 8. Columns 2-5 provide a description of the tissue or cell source.
Codes
corresponding to diseased tissues are indicated in column 6 with the word
"disease". The use
of the word "disease" in column 6 is non-limiting. The tissue or cell source
may be specific
(e.g. a neoplasm), or may be disease-associated (e.g., a tissue sample from a
normal portion
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of a diseased organ). Furthermore, tissues and/or cells lacking the "disease"
designation may
still be derived from sources directly or indirectly involved in a disease
state or disorder, and
therefore may have a further utility in that disease state or disorder. In
numerous cases where
the tissue/cell source is a library, column 7 identifies the vector used to
generate the library.
[17] Table 5 provides a key to the OMIM reference identification numbers
disclosed in
Table 1A, column 10. OMIM reference identification numbers (Column 1) were
derived
from Online Mendelian Inheritance in Man (Online Mendelian Inheritance in Man,
OMIM.
McKusick-Nathans Institute for Genetic Medicine, Johns Hoplcins University
(Baltimore,
MD) and National Center for Biotechnology Information, National Library of
Medicine,
(Bethesda, MD) 2000. World Wide Web URL: http://www.ncbi.nlm.nih.gov/omim/).
Column 2 provides diseases associated with the cytologic band disclosed in
Table 1A,
column 9, as determined using the Morbid Map database.
[18] Table 6 summarizes ATCC Deposits, Deposit dates, and ATCC designation
numbers of deposits made with the ATCC in connection with the present
application.
[19] Table 7 shows the cDNA libraries sequenced, and ATCC designation numbers
and
vector information relating to these cDNA libraries.
[20] Table 8 provides a physical characterization of clones encompassed by the
invention. The first column provides the unique clone identifier, "Clone ID
NO:Z", for
certain cDNA clones of the invention, as described in Table 1A. The second
column provides
the size of the cDNA insert contained in the corresponding cDNA clone.
Definitions
[21] The following definitions are provided to facilitate understanding of
certain terms
used throughout this specification.
[22] In the present invention, "isolated" refers to material removed from its
original
environment (e.g., the natural environment if it is naturally occurring), and
thus is altered "by
the hand of man" from its natural state. For example, an isolated
polynucleotide could be
part of a vector or a composition of matter, or could be contained within a
cell, and still be
"isolated" because that vector, composition of matter, or particular cell is
not the original
environment of the polynucleotide. The term "isolated" does not refer to
genomic or cDNA
libraries, whole cell total or mRNA preparations, genomic DNA preparations
(including
those separated by electrophoresis and transferred onto blots), sheared whole
cell genomic
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DNA preparations or other compositions where the' art demonstrates no
distinguishing
features of the polynucleotide/sequences of the present invention.
[23] As used herein, a "polynucleotide" refers to a molecule having a nucleic
acid
sequence encoding SEQ ID NO:Y or a fragment or variant thereof; a nucleic acid
sequence
contained in SEQ ID NO:X (as described in column 3 of Table 1A) or the
complement
thereof; a cDNA sequence contained in Clone ID NO:Z (as described in column 2
of Table
1A and contained within a library deposited with the ATCC); a nucleotide
sequence encoding
the polypeptide encoded by a nucleotide sequence in SEQ ID NO:B as defined in
column 6
of Table 1B or a fragment or variant thereof; or a nucleotide coding sequence
in SEQ ID
NO:B as defined in column 6 of Table 1B or the complement thereof. For
example, the
polynucleotide can contain the nucleotide sequence of the full length cDNA
sequence,
including the 5' and 3' untranslated sequences, the coding region, as well as
fragments,
epitopes, domains, and variants of the nucleic acid sequence. Moreover, as
used herein, a
"polypeptide" refers to a molecule having an amino acid sequence encoded by a
polynucleotide of the invention as broadly defined (obviously excluding poly-
Phenylalanine
or poly-Lysine peptide sequences which result from translation of a polyA tail
of a sequence
corresponding to a cDNA).
[24] In the present invention, "SEQ ID NO:X" was often generated by
overlapping
sequences contained in multiple clones (contig analysis). A representative
clone containing
all or most of the sequence for SEQ ID NO:X is deposited at Human Genome
Sciences, Inc.
(HGS) in a catalogued and archived library. As shown, for example, in column 2
of Table
1A, each clone is identified by a cDNA Clone ID (identifier generally referred
to herein as
Clone ID NO:Z). Each Clone ID is unique to an individual clone and the Clone
ID is all the
information needed to retrieve a given clone from the HGS library.
Furthermore, certain
clones disclosed in this application have been deposited with the ATCC on
October 5, 2000,
having the ATCC designation numbers PTA 2574 and PTA 2575; and on January 5,
2001,
having the depositor reference numbers TS-1, TS-2, AC-1, and AC-2. In addition
to the
individual cDNA clone deposits, most of the cDNA libraries from which the
clones were
derived were deposited at the American Type Culture Collection (hereinafter
"ATCC").
Table 7 provides a list of the deposited cDNA libraries. One can use the Clone
ID NO:Z to
determine the library source by reference to Tables 6 and 7. Table 7 lists the
deposited
cDNA libraries by name and links each library to an ATCC Deposit. Library
names contain
four characters, for example, "HTWE." The name of a cDNA clone (Clone ID)
isolated from
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that library begins with the same four characters, for example "HTWEP07". As
mentioned
below, Table 1A correlates the Clone ID names with SEQ ID NO:X. Thus, starting
with an
SEQ ID NO:X, one can use Tables 1, 6 and 7 to determine the corresponding
Clone ID,
which library it came from and which ATCC deposit the library is contained in.
Furthermore,
it is possible to retrieve a given cDNA clone from the source library by
techniques known in
the art and described elsewhere herein. The ATCC is located at 10801
University Boulevard,
Manassas, Virginia 20110-2209, USA. The ATCC deposits were made pursuant to
the terms
of the Budapest Treaty on the international recognition of the deposit of
microorganisms for
the purposes of patent procedure.
[25] In specific embodiments, the polynucleotides of the invention are at
least 15, at
least 30, at least 50, at least 100, at least 125, at least 500, or at least
1000 continuous
nucleotides but are less than or equal to 300 kb, 200 kb, 100 kb, 50 kb, 15
kb, 10 kb, 7.Skb, 5
kb, 2.5 kb, 2.0 kb, or 1 kb, in length. In a further embodiment,
polynucleotides of the
invention comprise a portion of the coding sequences, as disclosed herein, but
do not
comprise all or a portion of any intron. In another embodiment, the
polynucleotides
comprising coding sequences do not contain coding sequences of a genomic
flanking gene
(i.e., 5' or 3' to the gene of interest in the genome). In other embodiments,
the
polynucleotides of the invention do not contain the coding sequence of more
than 1000, 500,
250, 100, 50, 25, 20, 15, 10, 5, 4, 3, 2, or 1 genomic flanking gene(s).
[26] A "polynucleotide" of the present invention also includes those
polynucleotides
capable of hybridizing, under stringent hybridization conditions, to sequences
contained in
SEQ ID NO:X, or the complement thereof (e.g., the complement of any one, two,
three, four,
or more of the polynucleotide fragments described herein), the polynucleotide
sequence
delineated in columns 8 and 9 of Table 2 or the complement thereof, and/or
cDNA sequences
contained in Clone ID NO:Z (e.g., the complement of any one, two, three, four,
or more of
the polynucleotide fragments, or the cDNA clone within the pool of cDNA clones
deposited
with the ATCC, described herein), and/or the polynucleotide sequence
delineated in column
6 of Table 1B or the complement thereof. "Stringent hybridization conditions"
refers to an
overnight incubation at 42 degree C in a solution comprising 50% formamide, Sx
SSC (750
mM NaCI, 75 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), Sx
Denhardt's
solution, 10% dextran sulfate, and 20 ~,g/ml denatured, sheared salmon sperm
DNA,
followed by washing the filters in O.lx SSC at about 65 degree C.
CA 02395858 2002-06-21
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[27] Also contemplated are nucleic acid molecules that hybridize to the
polynucleotides
of the present invention at lower stringency hybridization conditions. Changes
in the
stringency of hybridization and signal detection are primarily accomplished
through the
manipulation of formamide concentration (lower percentages of formamide result
in lowered
stringency); salt conditions, or temperature. For example, lower stringency
conditions
include an overnight incubation at 37 degree C in a solution comprising 6X
SSPE (20X SSPE
= 3M NaCI; 0.2M NaHZP04; 0.02M EDTA, pH 7.4), 0.5% SDS, 30% formamide, 100
ug/ml
salmon sperm blocking DNA; followed by washes at 50 degree C with 1XSSPE, 0.1%
SDS.
In addition, to achieve even lower stringency, washes performed following
stringent
hybridization can be done at higher salt concentrations (e.g. 5X SSC).
[28] Note that variations in the above conditions may be accomplished through
the
inclusion and/or substitution of alternate blocking reagents used to suppress
background in
hybridization experiments. Typical blocking reagents include Denhardt's
reagent, BLOTTO,
heparin, denatured salmon sperm DNA, and commercially available proprietary
formulations.
The inclusion of specific blocking reagents may require modification of the
hybridization
conditions described above, due to problems with compatibility.
[29] Of course, a polynucleotide which hybridizes only to polyA+ sequences
(such as
any 3' terminal polyA+ tract of a cDNA shown in the sequence listing), or to a
complementary stretch of T (or U) residues, would not be included in the
definition of
"polynucleotide," since such a polynucleotide would hybridize to any nucleic
acid molecule
containing a poly (A) stretch or the complement thereof (e.g., practically any
double-stranded
cDNA clone generated using oligo dT as a primer).
[30] The polynucleotide of the present invention can be composed of any
polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or
DNA or
modified RNA or DNA. For example, polynucleotides can be composed of single-
and
double-stranded DNA, DNA that is a mixture of single- and double-stranded
regions, single-
and double-stranded RNA, and RNA that is mixture of single- and double-
stranded regions,
hybrid molecules comprising DNA and RNA that may be single-stranded or, more
typically,
double-stranded or a mixture of single- and double-stranded regions. In
addition, the
polynucleotide can be composed of triple-stranded regions comprising RNA or
DNA or both
RNA and DNA. A polynucleotide may also contain one or more modified bases or
DNA or
RNA backbones modified for stability or for other reasons. "Modified" bases
include, for
example, tritylated bases and unusual bases such as inosine. A variety of
modifications can
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be made to DNA and RNA; thus, "polynucleotide" embraces chemically,
enzymatically, or
metabolically modified forms.
[31] The polypeptide of the present invention can be composed of amino acids
joined to
each other by peptide bonds or modified peptide bonds, i.e., peptide
isosteres, and may
contain amino acids other than the 20 gene-encoded amino acids. The
polypeptides may be
modified by either natural processes, such as posttranslational processing, or
by chemical
modification techniques which are well known in the art. Such modifications
are well
described in basic texts and in more detailed monographs, as well as in a
voluminous
research literature. Modifications can occur anywhere in a polypeptide,
including the peptide
backbone, the amino acid side-chains and the amino or carboxyl termini. It
will be
appreciated that the same type of modification may be present in the same or
varying degrees
at several sites in a given polypeptide. Also, a given polypeptide may contain
many types of
modifications. Polypeptides may be branched, for example, as a result of
ubiquitination, and
they may be cyclic, with or without branching. Cyclic, branched, and branched
cyclic
polypeptides may result from posttranslation natural processes or may be made
by synthetic
methods. Modifications include acetylation, acylation, ADP-ribosylation,
amidation,
covalent attaclunent of flavin, covalent attachment of a heme moiety, covalent
attachment of
a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid
derivative,
covalent attachment of phosphotidylinositol, cross-linking, cyclization,
disulfide bond
formation, demethylation, formation of covalent cross-links, formation of
cysteine, formation
of pyroglutamate, formylation, gamma-carboxylation, glycosylation, GPI anchor
formation,
hydroxylation, iodination, methylation, myristoylation, oxidation, pegylation,
proteolytic
processing, phosphorylation, prenylation, racemization, selenoylation,
sulfation, hansfer-
RNA mediated addition of amino acids to proteins 'such as arginylation, and
ubiquitination.
(See, for instance, PROTEINS - STRUCTURE AND MOLECULAR PROPERTIES, 2nd
Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993);
POSTTRANSLATIONAL COVALENT MODIFICATION OF PROTEINS, B. C. Johnson,
Ed., Academic Press, New York, pgs. 1-12 (1983); Seifter et al., Meth.
Enzymol. 182:626-
646 (1990); Rattan et al., Ann. N.Y. Acad. Sci. 663:48-62 (1992)).
[32] "SEQ ID NO:X" refers to a polynucleotide sequence described, for example,
in
Tables lAor 2, while "SEQ ID NO:Y" refers to a polypeptide sequence described
in column
6 of Table 1A. SEQ ID NO:X is identified by an integer specified in column 4
of Table 1A.
The polypeptide sequence SEQ ID NO:Y is a translated open reading frame (ORF)
encoded
12
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
by polynucleotide SEQ ID NO:X. "Clone ID NO:Z" refers to a cDNA clone
described in
column 2 of Table 1A.
[33] "A polypeptide having functional activity" refers to a polypeptide
capable of
displaying one or more known functional activities associated with a full-
length (complete)
protein. Such functional activities include, but are not limited to,
biological activity,
antigenicity [ability to bind (or compete with a polypeptide for binding) to
an anti-
polypeptide antibody], immunogenicity (ability to generate antibody which
binds to a
specific polypeptide of the invention), ability to form multimers With
polypeptides of the
invention, and ability to bind to a receptor or ligand for a polypeptide.
[34] The polypeptides of the invention can be assayed for functional activity
(e.g.
biological activity) using or routinely modifying assays known in the art, as
well as assays
described herein. Specifically, one of skill in the art may routinely assay
inflammation-
associated polypeptides (including fragments and variants) of the invention
for activity using
assays as described in Examples 29, 43, and 45.
[35] "A polypeptide having biological activity" refers to a polypeptide
exhibiting
activity similar to, but not necessarily identical to, an activity of a
polypeptide of the present
invention, including mature forms, as measured in a particular biological
assay, with or
without dose dependency. In the case where dose dependency does exist, it need
not be
identical to that of the polypeptide, but rather substantially similar to the
dose-dependence in
a given activity as compared to the polypeptide of the present invention
(i.e., the candidate
polypeptide will exhibit greater activity or not more than about 25-fold less
and, preferably,
not more than about tenfold less activity, and most preferably, not more than
about three-fold
less activity relative to the polypeptide of the present invention).
[36] Table 1A summarizes some of the polynucleotides encompassed by the
invention
(including contig sequences (SEQ ID NO:X) and clones (Clone ID NO:Z) and
further
summarizes certain characteristics of these polynucleotides and the
polypeptides encoded
thereby.
13
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
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[37] The first column in Table 1A provides the gene number in the application
corresponding to the clone identifier. The second column in Table 1A provides
a unique
"Clone ID NO:Z" for a cDNA clone related to each contig sequence disclosed in
Table 1A.
This clone ID references the cDNA clone which contains at least the 5' most
sequence of the
assembled contig and at least a portion of SEQ ID NO:X was determined by
directly
sequencing the referenced clone. The reference clone may have more sequence
than
described in the sequence listing or the clone may have less. In the vast
majority of cases,
however, the clone is believed to encode a full-length polypeptide. In the
case where a clone
is not full-length, a full-length cDNA can be obtained by methods described
elsewhere
herein.
[38] The third column in Table 1A provides a unique "Contig ID" identification
for
each contig sequence. The fourth column provides the "SEQ ID NO:" identifier
for each of
the contig polynucleotide sequences disclosed in Table 1A. The fifth column,
"ORF (From-
To)", provides the location (i.e., nucleotide position numbers) within the
polynucleotide
sequence "SEQ ID NO:X" that delineate the preferred open reading frame (ORF)
shown in
the sequence listing and referenced in Table 1A, column 6, as SEQ ID NO:Y.
Where the
nucleotide position number "To" is lower than the nucleotide position number
"From", the
preferred ORF is the reverse complement of the referenced polynucleotide
sequence.
[39] The sixth column in Table 1A provides the corresponding SEQ ID NO:Y for
the
polypeptide sequence encoded by the preferred ORF delineated in column 5. In
one
embodiment, the invention provides an amino acid sequence comprising, or
alternatively
consisting of, a polypeptide encoded by the portion of SEQ ID NO:X delineated
by "ORF
(From-To)". Also provided are polynucleotides encoding such amino acid
sequences and the
complementary strand thereto.
[40] Column 7 in Table 1A lists residues comprising epitopes contained in the
polypeptides encoded by the preferred ORF (SEQ ID NO:Y), as predicted using
the
algorithm of Jameson and Wolf, (1988) Comp. Appl. Biosci. 4:181-186. The
Jameson-Wolf
antigenic analysis was performed using the computer program PROTEAN (Version
3.11 for
the Power Macintosh, DNASTAR, Inc., 1228 South Park Street Madison, WI). In
specific
embodiments, polypeptides of the invention comprise, or alternatively consist
of, at least one,
two, three, four, five or more of the predicted epitopes as described in Table
1A. It will be
appreciated that depending on the analytical criteria used to predict
antigenic determinants,
the exact address of the determinant may vary slightly.
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[41] Column 8 in Table 1A provides an expression profile and library code:
count for
each of the contig sequences (SEQ ID NO:X) disclosed in Table 1A, which can
routinely be
combined with the information provided in Table 4 and used to determine the
tissues, cells,
and/or cell line libraries which predominantly express the polynucleotides of
the invention.
The first number in column 8 (preceding the colon), represents the tissue/cell
source
identifier code corresponding to the code and description provided in Table 4.
For those
identifier codes in which the first two letters are not "AR", the second
number in column 8
(following the colon) represents the number of times a sequence corresponding
to the
reference polynucleotide sequence was identified in the tissue/cell source.
Those tissue/cell
source identifier codes in which the first two letters are "AR" designate
information
generated using DNA array technology. Utilizing this technology, cDNAs were
amplified by
PCR and then transferred, in duplicate, onto the array. Gene expression was
assayed through
hybridization of first strand cDNA probes to the DNA array. cDNA probes were
generated
from total RNA extracted from a variety of different tissues and cell lines.
Probe synthesis
was performed in the presence of 33P dCTP, using oligo(dT) to prime reverse
transcription.
After hybridization, high stringency washing conditions were employed to
remove non-
specific hybrids from the array. The remaining signal, emanating from each
gene target, was
measured using a Phosphorimager. Gene expression was reported as Phosphor
Stimulating
Luminescence (PSL) which reflects the level of phosphor signal generated from
the probe
hybridized to each of the gene targets represented on the array. A local
background signal
subtraction was performed before the total signal generated from each array
was used to
normalize gene expression between the different hybridizations. The value
presented after
"[array code]:" represents the mean of the duplicate values, following
background subtraction
and probe normalization. One of skill in the art could routinely use this
information to
identify normal and/or diseased tissues) which show a predominant expression
pattern of the
corresponding polynucleotide of the invention or to identify polynucleotides
which show
predominant and/or specific tissue and/or cell expression.
[42] Column 9 in Table 1A provides a chromosomal map location for certain
polynucleotides of the invention. Chromosomal location was determined by
finding exact
matches to EST and cDNA sequences contained in the NCBI (National Center for
Biotechnology Information) UniGene database. Each sequence in the UniGene
database is
assigned to a "cluster"; all of the ESTs, cDNAs, and STSs in a cluster are
believed to be
derived from a single gene. Chromosomal mapping data is often available for
one or more
180
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
sequences) in a UniGene cluster; this data (if consistent) is then applied to
the cluster as a
whole. Thus, it is possible to infer the chromosomal location of a new
polynucleotide
sequence by determining its identity with a mapped UniGene cluster.
[43] A modified version of the computer program BLASTN (Altshul et al., J.
Mol.
Biol. 215:403-410 (1990); and Gish and States, Nat. Genet. 3:266-272 (1993))
was used to
search the UniGene database for EST or cDNA sequences that contain exact or
near-exact
matches to a polynucleotide sequence of the invention (the 'Query'). A
sequence from the
UniGene database (the 'Subject') was said to be an exact match if it contained
a segment of
50 nucleotides in length such that 48 of those nucleotides were in the same
order as found in
the Query sequence. If all of the matches that met this criteria were in the
same UniGene
cluster, and mapping data was available for this cluster, it is indicated in
Table 1 A under the
heading "Cytologic Band". Where a cluster had been further localized to a
distinct cytologic
band, that band is disclosed; where no banding information was available, but
the gene had
been localized to a single chromosome, the chromosome is disclosed.
[44] Once a presumptive chromosomal location was determined for a
polynucleotide of
the invention, an associated disease locus was identified by comparison with a
database of
diseases which have been experimentally associated with genetic loci. The
database used was
the Morbid Map, derived from OMIMTM (supra). If the putative chromosomal
location of a
polynucleotide of the invention (Query sequence) was associated with a disease
in the
Morbid Map database, an OMIM reference identification number was noted in
column 10,
Table 1A, labelled "OMIM Disease References)". Table 5 is a key to the OMIM
reference
identification numbers (column 1), and provides a description of the
associated disease in
Column 2.
181
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TABLE 1B
Clone ID SEQ ID CONTIG BAC ID: SEQ ID EXON
A
NO:Z NO:X ID: NO:B From-To
HMSKF13 31 708207 AC023891 851 1-32
159-474
659-1496
2796-2957
3160-3603
5493-5676
8391-8506
8716-8880
8891-9116
9977-10703
II326-12477
HMSKF13 31 708207 AC023891 852 1-169
HLHCT68 36 764745 AC010344 853 1-121
2985-3815
4282-4423
HLHCT68 36 764745 AC008496 854 1-96
2321-2645
5406-5532
5545-5688
6055-6205
9065-9895
10362-10503
HLHCT68 36 764745 AC010344 855 1-144
HLHCT68 36 764745 AC010344 856 1-2396
HLHCT68 36 764745 AC008496 857 l-1684
HNHEQ86 39 785580 AC024653 858 1-731
HTOIA82 43 844319 AC012446 859 1-410
HTOIA82 43 844319 AC012446 860 1-329
HEOPE58 45 851009 AL078634 861 1-40
1089-1226
3206-3637
4312-4463
7455-8330
8603-8815
9078-9190
9522-9767
10946-12260
13754-14357
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WO 01/54474 PCT/USO1/01349
15092-15830
18660-18822
21128-21635
21685-21721
HEOPE58 45 851009 AL078634 862 1-235
3051-3154
3199-3734
HEOPE58 45 851009 AL078634 863 1-444
HSSJM44. 51 871067 AC026352 864 1-2314
HSSJM44 51 871067 AC068755 865 1-2311
HSSJM44 51 871067 AC069443 866 1-2314
HSSJM44 51 871067 AC026352 867 I-430
HSSJM44 51 871067 AC068755 868 1-430
HSSJM44 51 871067 AC069443 869 1-430
HCFLI54 59 921382 AC023278 870 1-1977
2006-3504
3 802-4090
4113-6041
6143-6242
6252-6919
6933-7614
7682-8351
HCFLI54 59 921382 AC005562 871 1-3490
3783-4087
4094-623
8
6249-6901
6930-7364
7701-8350
HCFLI54 59 921382 AC023278 872 1-574
774-1443
HCFLI54 59 921382 AC023278 873 1-616
HCFLI54 59 921382 AC005562 874 1-667
HLMD095 62 928344 AC020641 875 1-591
627-2046
HDPSJ02 66 943316 AL109804 876 1-161
684-1524
1611-1868
2185-2484
2550-3044
3158-3539
4120-4422
183
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WO 01/54474 PCT/USO1/01349
4682-4784
5155-5227
5763-7414
HDPSJ02 66 943316 AL109804 877 1-442
HDPSJ02 66 943316 AL109804 878 1-86
393-695
2345-2611
2985-3904
4603-5446
5467-5608
6481-6582
6976-7234
7899-8638
9094-9354
9548-10236
HBGQN46 67 945370 AF038458 879 1-630
1311-1416
2481-4022
4952-5252
6370-6479
7623-8269
HRODF07 69 952426 AC023402 880 1-336
HRODF07 69 952426 AC011597 881 1-336
HEGA083 87 780837 AC024009 882 1-880
1967-2289
2746-2890
3236-3284
HEGAO83 87 780837 AC040991 883 1-880
1967-2288
2745-2889
3235-3283
HEGA083 87 780837 AC040991 884 1-176
HHFCI36 99 844285 AC073582 885 1-348
HHFCI36 99 844285 AC011307 886 1-738
777-928
6547-8986
9041-9656
HHFCI36 99 844285 AC011302 887 1-167
5786-8225
8280-8895
HHFCI36 99 844285 AC004616 888 1-890
184
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WO 01/54474 PCT/USO1/01349
1656-2025
6359-9765
HHFCI36 99 844285 AC073582 889 1-1884
HHFCI36 99 844285 AC011307 890 1-5863
8965-9695
9824-11213
11438-11774
12992-13348
14833-14982
18797-19148
19635-20733
20793-23092
23268-23517
23704-25018
25022-25395
HHFCI36 99 844285 ACOI1302 891 1-602
HHFCI36 99 844285 AC011302 892 1-5861
8963-9683
9822-11211
11436-11772
12990-13346
14831-14980
18796-19146
19633-20731
20802-23090
23266-23515
23772-25006
25020-25393
HACCH94 101 847143 AL161458 893 1-1140
HACCH94 101 847143 AL161458 894 1-90
5811-6312
HDPND85 104 852628 AC003042 895 1-261
1877-2339
3059-3286
3970-4326
4931-5114
6268-6359
7022-7866
7877-8140
8262-8911
HDPND85 104 1 852628 AC003042 896 1-754
185
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WO 01/54474 PCT/USO1/01349
955-1048
6079-6214
6309-6423
6705-7373
HI~ABI68 105 856590 AC007606 897 1-650
709-802
3445-3584
3925-4225
4428-4595
5220-5285
5346-5673
5789-5962
7106-7206
8427-8807
9869-10247
10688-11328
11382-12036
12610-13224
HKABI68 105 856590 AC007606 898 1-1215
1651-1783
1974-2304
2681-2756
HWHP029 106 857383 AL049779 899 1-210
1909-2318
2599-2753
3548-3655
4479-4690
6391-6879
7696-8065
10475-10649
11240-11950
HBGDA14 108 866258 AC074220 900 1-919
HBGDA14 108 866258 AC024580 901 1-682
HMKCH92 126 910936 AC026206 902 1-52
416-535
1184-1340
1502-1651
4581-4649
10517-10753
10870-10987
13190-13220
186
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HMKCH92 126 910936 AC034192 903 1-52
416-535
1184-1338
1500-1651
4583-4659
10526-10754
10871-10957
HMKCH92 126 910936 AC022381 904 1-52
416-535
1184-1340
1502-1651
4583-4651
10520-10756
10873-10990
13187-13217
HMKCH92 126 910936 AC026206 905 1-107
HMKCH92 126 910936 AC022381 906 1-107
HBGMZ39 151 947112 AC008537 907 1-1186
HBGMZ39 151 947112 AC019337 908 1-1182
HBGMZ39 151 947112 AC008537 909 1-1993
2105-2385
2736-3068
4364-4489
6546-6781
7025-8165
HBGMZ39 151 947112 AC019337 910 1-1991
2103-23
83
2734-3066
4360-4485
6541-6776
7021-8159
HBGMZ39 151 947112 AC008537 911 1-734
767-1001
HBGMZ39 151 947112 AC019337 912 1-158
291-565
598-832
HSDJM56 159 948669 AC009524 913 1-S41
HNTND64 171 954871 AC025090 914 1-465
HNTND64 171 954871 AC025090 915 1-454
HMTAV95 197 614936 AL137000 916 1-47
321-642
187
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WO 01/54474 PCT/USO1/01349
2386-2508
3316-3493
4104-4572
6015-6340
6520-6573
HMTAV95 197 614936 AL137000 917 1-539
HMTAV95 197 614936 AL137000 918 1-510
HHFGP83 202 828162 AC026348 919 1-62
528-1080
1104-1284
1836-1940
2308-2633
HHFGP83 202 828162 AC026329 920 1-102
461-611
3520-3678
4094-4203
4670-5222
5246-5426
5978-6082
6450-6775
8830-9053
9755-10066
10098-10279
10355-10988
12072-13795
HE9TK49 205 856343 AC021491 921 1-138
546-642
2717-2876
3393-3695
3838-4513
HE9TK49 205 856343 AC004590 922 1-138
546-642
2735-2894
3411-3713
3856-4531
HFKJ015 215 910828 AC005500 923 1-180
288-509
63 8-770
1363-1466
1541-1661
1829-1971
188
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WO 01/54474 PCT/USO1/01349
1988-2162
3576-3797
4349-4491
4913-6610
HFKJ015 215 910828 AC007731 924 1-180
288-509
638-770
1363-1466
1541-1661
1829-1971
1988-2162
3576-3797
4349-4491
4913-6610
HFKJ015 215 910828 AC005500 925 1-97
305-602
HFKJ015 215 910828 AC007731 926 1-97
.
305-602
HCQCI06 220 915000 AC068763 927 1-590
819-1083
HCQCI06 220 915000 AC069223 928 1-362
HCQCI06 220 915000 AC068763 929 1-593
HWMEV63 225 931154 AC078816 930 1-1574
HFKKE19 239 947418 AL356389 931 1-721
HFKKE19 239 947418 AL157901 932 1-721
HHFME38 243 947970 AC011307 933 1-738
777-928
6547-8986
9041-9656
HHFME38 243 947970 AC011302 934 1-602
HHFME38 243 947970 AC004616 935 1-890
1656-2025
6359-9765
HHFME38 243 947970 AC011307 936 1-5863
8965-9695
9824-11213
11438-11774
12992-13348
14833-14982
18797-19148
19635-20733
189
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WO 01/54474 PCT/USO1/01349
20793-23092
23268-23517
23704-25018
25022-25395
HHFME38 243 947970 ACOlI302 937 I-167
5786-8225
8280-8895
HETKR83 254 963274 AC044883 938 1-637
HE8UT58 264 973153 AC032004 939 1-120
190
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[45] Table 1B summarizes additional polynucleotides encompassed by the
invention
{including cDNA clones related to the sequences (Clone ID NO:Z), contig
sequences (contig
identifier (Contig ID:) contig nucleotide sequence identifiers {SEQ ID NO:X)),
and genomic
sequences (SEQ ID NO:B). The first column provides a unique clone identifier,
"Clone ID
NO:Z", for a cDNA clone related to each contig sequence. The second column
provides the
sequence identifier, "SEQ ID NO:X", for each contig sequence. The third column
provides a
unique contig identifier, "Contig TD:" for each contig sequence. The fourth
coluxmi, provides
a BAC identifier "BAC ID NO:A" for the BAC clone referenced in the
corresponding row of
the table. The fifth column provides the nucleotide sequence identifier, "SEQ
ID NO:B" for
a fragment of the BAC clone identified in column four of the corresponding row
of the table.
The sixth column, "Exon From-To", provides the location (i.e., nucleotide
position numbers)
within the polynucleotide sequence of SEQ ID NO:B which delineate certain
polynucleotides
of the invention that are also exemplary members of polynucleotide sequences
that encode
polypeptides of the invention (e.g., polypeptides containing amino acid
sequences encoded
by the polynucleotide sequences delineated in column six, and fragments and
variants
thereof).
191
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
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194
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288
CA 02395858 2002-06-21
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289
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290
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291
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292
CA 02395858 2002-06-21
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CA 02395858 2002-06-21
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294
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CA 02395858 2002-06-21
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CA 02395858 2002-06-21
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323
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
[46] Table 2 further characterizes certain encoded polypeptides of the
invention, by
providing the results of comparisons to protein and protein family databases.
The first
column provides a unique clone identifier, "Clone ID NO:", corresponding to a
cDNA
clone disclosed in Table 1A. The second column provides the unique contig
identifier,
"Contig ID:" which allows correlation with the information in Table 1A. The
third column
provides the sequence identifier, "SEQ ID NO:", for the contig polynucleotide
sequences.
The fourth column provides the analysis method by which the homology/identity
disclosed
in the Table was determined. The fifth column provides a description of the
PFAM/NR hit
identified by each analysis. Column six provides the accession number of the
PFAM/NR
hit disclosed in the fifth column. Column seven, score/percent identity,
provides a quality
score or the percent identity, of the hit disclosed in column five.
Comparisons were made
between polypeptides encoded by polynucleotides of the invention and a non-
redundant
protein database (herein referred to as "NR"), or a database of protein
families (herein
referred to as "PFAM"), as described below.
[47] The NR database, which comprises the NBRF PIR database, the NCBI GenPept
database, and the SIB SwissProt and TrEMBL databases, was made non-redundant
using
the computer program nrdb2 (Warren Gish, Washington University in Saint
Louis). Each of
the polynucleotides shown in Table 1A, column 3 (e.g., SEQ ID NO:X or the
'Query'
sequence) was used to search against the NR database. The computer program
BLASTX
was used to compare a 6-frame translation of the Query sequence to the NR
database (for
information about the BLASTX algorithm please see Altshul et al., J. Mol.
Biol. 215:403-
410 (1990); and Gish and States, Nat. Genet. 3:266-272 (1993). A description
of the
sequence that is most similar to the Query sequence (the highest scoring
'Subject') is shown
in column five of Table 2 and the database accession number for that sequence
is provided
in column six. The highest scoring 'Subject' . is reported in Table 2 if (a)
the estimated
probability that the match occurred by chance alone is less than 1.0e-07, and
(b) the match
was not to a known repetitive element. BLASTX returns alignments of short
polypeptide
segments of the Query and Subject sequences which share a high degree of
similarity; these
segments are known as High-Scoring Segment Pairs or HSPs. Table 2 reports the
degree of
similarity between the Query and the Subject for each HSP as a percent
identity in Column
7. The percent identity is determined by dividing the number of exact matches
between the
two aligned sequences in the HSP, dividing by the number of Query amino acids
in the HSP
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CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
and multiplying by 100. The polynucleotides of SEQ ID NO:X which encode the
polypeptide sequence that generates an HSP are delineated by columns 8 and 9
of Table 2.
[48] The PFAM database, PFAM version 2.1, (Sonnhammer et al., Nucl. Acids
Res.,
26:320-322, 1998)) consists of a series of multiple sequence alignments; one
alignment for
each protein family. Each multiple sequence alignment is converted into a
probability
model called a Hidden Markov Model, or HMM, that represents the position-
specific
variation among the sequences that make up the multiple sequence alignment
(see, e.g.,
Durbin et al., Biological sequence af2alysis: probabilistic models of
p~°oteiris afZd nucleic
acids, Cambridge University Press, 1998 for the theory of HMMs). The program
HMMER
version 1.8 (Sean Eddy, Washington University in Saint Louis) was used to
compare the
predicted protein sequence for each Query sequence (SEQ ID NO:Y in Table 1A)
to each of
the HMMs derived from PFAM version 2.1. A HMM derived from PFAM version 2.1
was
said to be a significant match to a polypeptide of the invention if the score
returned by
HMMER 1.8 was greater than 0.8 times the HMMER 1.8 score obtained with the
most
distantly related known member of that protein family. The description of the
PFAM family
which shares a significant match with a polypeptide of the invention is listed
in column 5
of Table 2, and the database accession number of the PFAM hit is provided in
column 6.
Column 7 provides the score returned by HMMER version 1.8 for the alignment.
Columns
8 and 9 delineate the polynucleotides of SEQ ID NO:X which encode the
polypeptide
sequence which show a significant match to a PFAM protein family.
[49] As mentioned, columns 8 and 9 in Table 2, "NT From" and "NT To",
delineate
the polynucleotides of "SEQ ID NO:X" that encode a polypeptide having a
significant
match to the PFAM/NR database as disclosed in the fifth column. In one
embodiment, the
invention provides a protein comprising, or alternatively consisting of, a
polypeptide
encoded by the polynucleotides of SEQ ID NO:X delineated in columns 8 and 9 of
Table 2.
Also provided are polynucleotides encoding such proteins, and the
complementary strand
thereto.
[50] The nucleotide sequence SEQ ID NO:X and the translated SEQ ID NO:Y are
sufficiently accurate and otherwise suitable for a variety of uses well known
in the art and
described further below. For instance, the nucleotide sequences of SEQ ID NO:X
are
useful for designing nucleic acid hybridization probes that will detect
nucleic acid
sequences contained in SEQ ID NO:X or the cDNA contained in Clone ID NO:Z.
These
probes will also hybridize to nucleic acid molecules in biological samples,
thereby enabling
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WO 01/54474 PCT/USO1/01349
immediate applications in chromosome mapping, linkage analysis, tissue
identification
and/or typing, and a variety of forensic and diagnostic methods of the
invention. Similarly,
polypeptides identified from SEQ ID NO:Y may be used to generate antibodies
which bind
specifically to these polypeptides, or fragments thereof, and/or to the
polypeptides encoded
by the cDNA clones identified in, for example, Table 1A.
[51] Nevertheless, DNA sequences generated by sequencing reactions can contain
sequencing errors. The errors exist as misidentified nucleotides, or as
insertions or
deletions of nucleotides in the generated DNA sequence. . The erroneously
inserted or
deleted nucleotides cause frame shifts in the reading frames of the predicted
amino acid
sequence. In these cases, the predicted amino acid sequence diverges from the
actual amino
acid sequence, even though the generated DNA sequence may be greater than
99.9%
identical to the actual DNA sequence (for example, one base insertion or
deletion in an
open reading frame of over 1000 bases).
[52] - Accordingly, for those applications requiring precision in the
nucleotide
sequence or the amino acid sequence, the present invention provides not only
the generated
nucleotide sequence identified as SEQ ID NO:X, and a predicted translated
amino acid
sequence identified as SEQ ID NO:Y, but also a sample of plasmid DNA
containing cDNA
Clone ID NO:Z (deposited with the ATCC on October 5, 2000, and receiving ATCC
designation numbers PTA 2574 and PTA 2575; deposited with the ATCC on January
5,
2001, and having depositor reference numbers TS-1, TS-2, AC-l, and AC-2;
and/or as set
forth, for example, in Table 1A, 6 and 7). The nucleotide sequence of each
deposited clone
can readily be determined by sequencing the deposited clone in accordance with
known
methods: Further, techniques known in the art can be used to verify the
nucleotide
sequences of SEQ ID NO:X.
[53] The predicted amino acid sequence can then be verified from such
deposits.
Moreover, the amino acid sequence of the protein encoded by a particular clone
can also be
directly determined by peptide sequencing or by expressing the protein in a
suitable host
cell containing the deposited human cDNA, collecting the protein, and
determining its
sequence.
RACE Pt~otocol For Recovery of Full Lefzgtlz Genes
[54] Partial cDNA clones can be made full-length by utilizing the rapid
amplification
of cDNA ends (RACE) procedure described in Frohman, M.A., et al., Proc. Nat'l.
Acad.
326
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WO 01/54474 PCT/USO1/01349
Sci. USA, 85:8998-9002 (1988). A cDNA clone missing either the 5' or 3' end
can be
reconstructed to include the absent base pairs extending to the translational
start or stop
codon, respectively. In some cases, cDNAs are missing the start codon of
translation,
therefor. The following briefly describes a modification of this original 5'
RACE
procedure. Poly A+ or total RNA is reverse transcribed with Superscript II
(Gibco/BRL)
and an antisense or complementary primer specific to the cDNA sequence. The
primer is
removed from the reaction with a Microcon Concentrator (Amicon). The first-
strand cDNA
is then tailed with dATP and terminal deoxynucleotide transferase (GibcoBRL).
Thus, an
anchor sequence is produced which is needed for PCR amplification. The second
strand is
synthesized from the dA-tail in PCR buffer, Taq DNA polymerase {Perkin-Elmer
Cetus), an
oligo-dT primer containing three adjacent restriction sites (XhoI, SaII and
CIaI) at the 5' end
and a primer containing just these restriction sites. This double-stranded
cDNA is PCR
amplified for 40 cycles with the same primers as well as a nested cDNA-
specific antisense
primer. The PCR products are size-separated on an ethidium bromide-agarose gel
and the
region of gel containing cDNA products the predicted size of missing protein-
coding DNA
is removed. cDNA is purified from the agarose with the Magic PCR Prep kit
(Promega),
restriction digested with XhoI or SaII, and ligated to a plasmid such as
pBluescript SKII
(Stratagene) at XhoI and EcoRV sites. This DNA is transformed into bacteria
and the
plasmid clones sequenced to identify the correct protein-coding inserts.
Correct 5' ends are
confirmed by comparing this sequence with the putatively identified homologue
and
overlap with the partial cDNA clone. Similar methods known in the art and/or
commercial
kits are used to amplify and recover 3' ends.
[55] Several quality-controlled kits are commercially available for purchase.
Similar
reagents and methods to those above are supplied in kit form from Gibco/BRL
for both 5'
and 3' RACE for recovery of full length genes. A second kit is available from
Clontech
which is a modification of a related technique, SLIC (single-stranded ligation
to single-
stranded cDNA), developed by Dumas et al., Nucleic Acids Res., 19:5227-32
(1991). The
major differences in procedure are that the RNA is alkaline hydrolyzed after
reverse
transcription and RNA ligase is used to join a restriction site-containing
anchor primer to
the first-strand cDNA. This obviates the necessity for the dA-tailing reaction
which results
in a polyT stretch that is difficult to sequence past.
[56] An alternative to generating 5' or 3' cDNA from RNA is to use cDNA
library
double-stranded DNA. An asymmetric PCR-amplified antisense cDNA strand is
327
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
synthesized with an antisense cDNA-specific primer and a plasmid-anchored
primer. These
primers are removed and a symmetric PCR reaction is performed with a nested
cDNA-
specific antisense primer and the plasmid-anchored primer.
RNA Ligase Protocol Fof~ Generating The 5' of~ 3' End Sequences To Obtain Full
Lengtla
Genes
[57] Once a gene of interest is identified, several methods are available for
the
identification of the 5' or 3' portions of the gene which may not be present
in the original
cDNA plasmid. These methods include, but axe not limited to, filter probing,
clone .
enrichment using specific probes and protocols similar and identical to 5' and
3' RACE.
While the full length gene may be present in the library and can be identified
by probing, a
useful method for generating the 5' or 3' end is to use the existing sequence
information
from the original cDNA to generate the missing information. A method similar
to 5' RACE
is available for generating the missing 5' end of a desired full-length gene.
(This method
was published by Fromont-Racine et al., Nucleic Acids Res., 21(7):1683-1684
(1993)).
Briefly, a specific RNA oligonucleotide is ligated to the 5' ends of a
population of RNA
presumably containing full-length gene RNA transcript and a primer set
containing a primer
specific to the ligated RNA oligonucleotide and a primer specific to a known
sequence of
the gene of interest, is used to PCR amplify the 5' portion of the desired
full length gene
which may then be 'sequenced and used to generate the full length gene. This
method starts
with total RNA isolated from the desired source, poly A RNA may be used but is
not a
prerequisite for this procedure. The RNA preparation may then be treated with
phosphatase
if necessary to eliminate 5' phosphate groups on degraded or damaged RNA which
may
interfere with the later RNA Iigase step. The phosphatase if used is then
inactivated and the
RNA is treated with tobacco acid pyrophosphatase in order to remove the cap
structure
present at the 5' ends of messenger RNAs. This reaction leaves a 5' phosphate
group at the
5' end of the cap cleaved RNA which can then be ligated to an RNA
oligonucleotide using
T4 RNA ligase. This modified RNA preparation can then be used as a template
for first
strand cDNA synthesis using a gene specific oligonucleotide. The first strand
synthesis
reaction can then be used as a template for PCR amplification of the desired
5' end using a
primer specific to the ligated RNA oligonucleotide and a primer specific to
the known
sequence of the gene of interest. The resultant product is then sequenced and
analyzed to
confirm that the 5' end sequence belongs to the relevant gene.
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[58] The present invention also relates to vectors or plasmids which include
such
DNA sequences, as well as the use of the DNA sequences. The material deposited
with the
ATCC (deposited with the ATCC on October 5, 2000, and receiving ATCC
designation
numbers PTA 2574 and PTA 2575; deposited with the ATCC on January 5, 2001, and
receiving ATCC designation numbers TS-1, TS-2, AC-1, and AC-2; and/or as set
forth, for
example, in Table 1A, Table 6, or Table 7) is a mixture of cDNA clones derived
from a
variety of human tissue and cloned in either a plasmid vector or a phage
vector, as
described, for example, in Table 7. These deposits are referred to as "the
deposits" herein.
The tissues from which some of the clones were derived are listed in Table 7,
and the vector
in which the corresponding cDNA is contained is also indicated in Table 7. The
deposited
material includes cDNA clones corresponding to SEQ ID NO:X described, for
example, in
Table 1A (Clone ID NO:Z). A clone which is isolatable from the ATCC Deposits
by use of
a sequence listed as SEQ ID NO:X, may include the entire coding region of a
human gene
or in other cases such clone may include a substantial portion of the coding
region of a
human gene. Furthermore, although the sequence listing may in some instances
list only a
portion of the DNA sequence in a clone included in the ATCC Deposits, it is
well within
the ability of one skilled in the art to sequence the DNA included in a clone
contained in the
ATCC Deposits by use of a sequence (or portion thereof) described in, for
example Tables
lAor 2 by procedures hereinafter further described, and others apparent to
those skilled in
the art.
[59] Also provided in Table 7 is the name of the vector which contains the
cDNA
clone. Each vector is routinely used in the art. The following additional
information is
provided for convenience.
[60] Vectors Lambda Zap (U.S. Patent Nos. 5,128,256 and 5,286,636), Uni-Zap XR
(U.S. Patent Nos. 5,128, 256 and 5,286,636), Zap Express (U.S. Patent Nos.
5,128,256 and
5,286,636), pBluescript (pBS) (Short, J. M. et al., Nucleic Acids Res. 16:7583-
7600 (1988);
Alting-Mees, M. A. and Short, J. M., Nucleic Acids Res. 17: 9494 (1989)) and
pBK (Alting-
Mees, M. A. et al., Strategies 5:58-61 (1992)) are commercially available from
Stratagene
Cloning Systems, Inc., 11011 N. Torrey Pines Road, La Jolla, CA, 92037. pBS
contains an
ampicillin resistance gene and pBK contains a neomycin resistance gene.
Phagemid pBS
may be excised from the Lambda Zap and Uni-Zap XR vectors, and phagemid pBK
may be
excised from the Zap Express vector. Both phagemids may be transformed into E.
coli
strain XL-1 Blue, also available from Stratagene.
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WO 01/54474 PCT/USO1/01349
[61] Vectors pSportl, pCMVSport 1.0, pCMVSport 2.0 and pCMVSport 3.0, were
obtained from Life Technologies, Inc., P. O. Box 6009, Gaithersburg, MD 20897.
All Sport
vectors contain an ampicillin resistance gene and may be transformed into E.
coli strain
DH10B, also available from Life Technologies. See, for instance, Gruber, C.
E., et al.,
Focus 15: 59- (1993). Vector lafinid BA (Bento Soares, Columbia University,
New York,
NY) contains an ampicillin resistance gene and can be transformed into E. coli
strain XL-1
Blue. Vector pCR~2.1, which is available from Invitrogen, 1600 Faraday Avenue,
Carlsbad,
CA 92008, contains an ampicillin resistance gene and may be transformed into
E. coli
strain DHlOB, available from Life Technologies. See, for instance, Clark, J.
M., Nuc. Acids
Res. 16.9677-9686 (1988) and Mead, D. et al., BiolTechhology 9: (1991).
[62] The present invention also relates to the genes corresponding to SEQ ID
NO:X,
SEQ ID NO:Y, and/or the deposited clone (Clone ID NO:Z). The corresponding
gene can
be isolated in accordance with known methods using the sequence information
disclosed
herein. Such methods include preparing probes or primers from the disclosed
sequence and
identifying or amplifying the corresponding gene from appropriate sources of
genomic
material.
[63] Also provided in the present invention are allelic variants, orthologs,
and/or
species homologs. Procedures known in the art can be used to obtain full-
length genes,
allelic variants, splice variants, full-length coding portions, orthologs,
and/or species
homologs of genes corresponding to SEQ ID NO:X or the complement thereof,
polypeptides encoded by genes corresponding to SEQ ID NO:X or the complement
thereof,
and/or the cDNA contained in Clone ID NO:Z, using information from the
sequences
disclosed herein or the clones deposited with the ATCC. For example, allelic
variants
and/or species homologs may be isolated and identified by making suitable
probes or
primers from the sequences provided herein and screening a suitable nucleic
acid source for
allelic variants and/or the desired homologue.
[64] The polypeptides of the invention can be prepared in any suitable manner.
Such
polypeptides include isolated naturally occurring polypeptides, recombinantly
produced
polypeptides, synthetically produced polypeptides, or polypeptides produced by
a
combination of these methods. Means for preparing such polypeptides are well
understood
in the art.
[65] The polypeptides may be in the form of the secreted protein, including
the mature
form, or may be a part of a larger protein, such as a fusion protein (see
below). It is often
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CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
advantageous to include an additional amino acid sequence which contains
secretory or
leader sequences, pro-sequences, sequences which aid in purification, such as
multiple
histidine residues, or an additional sequence for stability during recombinant
production.
[66] The polypeptides of the present invention are preferably provided in an
isolated
form, and preferably are substantially purified. A recombinantly produced
version of a
polypeptide, including the secreted polypeptide, can be substantially purified
using
techniques described herein or otherwise known in the art, such as, for
example, by the one-
step method described in Smith and Johnson, Gene 67:31-40 (1988). Polypeptides
of the
invention also can be purified from natural, synthetic or recombinant sources
using
techniques described herein or otherwise known in the art, such as, for
example, antibodies
of the invention raised against the polypeptides of the present invention in
methods which
are well known in the art.
[67] The present invention provides a polynucleotide comprising, or
alternatively
consisting of, the nucleic acid sequence of SEQ ID NO:X, and/or the cDNA
sequence
contained in Clone ID NO:Z. The present invention also provides a polypeptide
comprising, or alternatively, consisting of, the polypeptide sequence of SEQ
ID NO:Y, a
polypeptide encoded by SEQ ID NO:X or a complement thereof, a polypeptide
encoded by
the cDNA contained in Clone ID NO:Z, and/or the polypeptide sequence encoded
by a
nucleotide sequence in SEQ ID NO:B as defined in column 6 of Table 1B.
Polynucleotides
encoding a polypeptide comprising, or alternatively consisting of the
polypeptide sequence
of SEQ ID NO:Y, a polypeptide encoded by SEQ ID NO:X, a polypeptide encoded by
the
cDNA contained in Clone ID NO:Z, and/or a polypeptide sequence encoded by a
nucleotide
sequence in SEQ ID NO:B as defined in column 6 of Table 1B are also
encompassed by the
invention. The present invention further encompasses a polynucleotide
comprising, or
alternatively consisting of, the complement of the nucleic acid sequence of
SEQ ID NO:X,
a nucleic acid sequence encoding a polypeptide encoded by the complement of
the nucleic
acid sequence of SEQ ID NO:X, andlor the cDNA contained in Clone ID NO:Z.
[68] Moreover, representative examples of polynucleotides of the invention
comprise,
or alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of
the sequences delineated in Table 1B column 6, or any combination thereof.
Additional,
representative examples of polynucleotides of the invention comprise, or
alternatively
consist of, one, two, three, four, five, six, seven, eight, nine, ten, or more
of the
complementary strands) of the sequences delineated in Table 1B column 6, or
any
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combination thereof. In further embodiments, the above-described
polynucleotides of the
invention comprise, or alternatively consist of, sequences delineated in Table
1B, column 6,
and have a nucleic acid sequence which is different from that of the BAC
fragment having
the sequence disclosed in SEQ ID NO:B (see Table 1B, column 5). In additional
embodiments, the above-described polynucleotides of the invention comprise, or
alternatively consist of, sequences delineated in Table 1B, column 6, and have
a nucleic
acid sequence which is different from that published for the BAC clone
identified as BAC
ID NO:A (see Table 1B, column 4). In additional embodiments, the above-
described
polynucleotides of the invention comprise, or alternatively consist of,
sequences delineated
in Table 1B, column 6, and have a nucleic acid sequence which is different
from that
contained in the BAC clone identified as BAC ID NO:A (see Table 1B, column 4).
Polypeptides encoded by these polynucleotides, other polynucleotides that
encode these
polypeptides, and antibodies that bind these polypeptides are also encompassed
by the
invention. Additionally, fragments and variants of the above-described
polynucleotides and
polypeptides are also encompassed by the invention.
[69] Further, representative examples of polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
sequences delineated in column 6 of Table 1B which correspond to the same
Clone ID
NO:Z (see Table 1B, column 1), or any combination thereof. Additional,
representative
examples of polynucleotides of the invention comprise, or alternatively
consist of, one, two,
three, four, five, six, seven, eight, nine, ten, or more of the complementary
strands) of the
sequences delineated in column 6 of Table 1B which correspond to the same
Clone ID
NO:Z (see Table 1B, column 1), or any combination thereof. In further
embodiments, the
above-described polynucleotides of the invention comprise, or alternatively
consist of,
sequences delineated in column 6 of Table 1B which correspond to the same
Clone ID
NO:Z (see Table 1B, column 1) and have a nucleic acid sequence which is
different from
that of the BAC fragment having the sequence disclosed in SEQ ID NO:B (see
Table 1B,
column 5). In additional embodiments, the above-described polynucleotides of
the
invention comprise, or alternatively consist of, sequences delineated in
column 6 of Table
1B which correspond to the same Clone ID NO:Z (see Table 1B, column 1) and
have a
nucleic acid sequence which is different from that published for the BAC clone
identified as
BAC ID NO:A (see Table 1B, column 4). In additional embodiments, the above-
described
polynucleotides of the invention comprise, or alternatively consist of,
sequences delineated
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in column 6 of Table 1B which correspond to the same Clone ID NO:Z (see Table
1B,
column 1) and have a nucleic acid sequence which is different from that
contained in the
BAC clone identified as BAC ID NO:A (see Table 1B, column 4). Polypeptides
encoded
by these polynucleotides, other polynucleotides that encode these
polypeptides, and
antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides
and
polypeptides are also encompassed by the invention.
[70] Further, representative examples of polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
sequences delineated in column 6 of Table 1B which correspond to the same
contig
sequence identifer SEQ ID NO:X (see Table 1B, column 2), or any combination
thereof.
Additional, representative examples of polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
complementary strands) of the sequences delineated in column 6 of Table 1B
which
correspond to the same contig sequence identifer SEQ ID NO:X (see Table IB,
column 2),
or any combination thereof. In fuxther embodiments, the above-described
polynucleotides
of the invention comprise, or alternatively consist of, sequences delineated
in column 6 of
Table 1B which correspond to the same contig sequence identifer SEQ ID NO:X
(see Table
1B, column 2) and have a nucleic acid sequence which is different from that of
the BAC
fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column
5). In
additional embodiments, the above-described polynucleotides of the invention
comprise, or
alternatively consist of, sequences delineated in column 6 of Table 1B which
correspond to
the same contig sequence identifer SEQ ID NO:X (see Table 1B, column 2) and
have a
nucleic acid sequence which is different from that published for the BAC clone
identified as
BAC ID NO:A (see Table 1B, column 4). In additional embodiments, the above-
described
polynucleotides of the invention comprise, or alternatively consist of,
sequences delineated
in column 6 of Table 1B which correspond to the same contig sequence identifer
SEQ ID
NO:X (see Table 1B, column 2) and have a nucleic acid sequence which is
different from
that contained in the BAC clone identified as BAC ID NO:A (See Table 1B,
column 4).
Polypeptides encoded by these polynucleotides, other polynucleotides that
encode these
polypeptides, and antibodies that bind these polypeptides are also encompassed
by the
invention. Additionally, fragments and variants of the above-described
polynucleotides and
polypeptides are also encompassed by the invention.
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[71] Moreover, representative examples of polynucleotides of the invention
comprise,
or alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of
the sequences delineated in the same row of Table 1B column 6, or any
combination
thereof. Additional, representative examples of polynucleotides of the
invention comprise,
or alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of
the complementary strands) of the sequences delineated in the same row of
Table 1B
column 6, or any combination thereof. In preferred embodiments, the
polynucleotides of
the invention comprise, or alternatively consist of, one, two, three, four,
five, six, seven,
eight, nine, ten, or more of the complementary strands) of the sequences
delineated in the
same row of Table 1B column 6, wherein sequentially delineated sequences in
the table (i.e.
corresponding to those exons located closest to each other) are directly
contiguous in a 5' to
3' orientation. In further embodiments, above-described polynucleotides of the
invention
comprise, or alternatively consist of, sequences delineated in the same row of
Table 1B,
column 6, and have a nucleic acid sequence which is different from that of the
BAC
fragment having the sequence disclosed in SEQ ID NO:B (see Table 1B, column
5). In
additional embodiments, the above-described polynucleotides of the invention
comprise, or
alternatively consist of, sequences delineated in the same row of Table 1B,
column 6, and
have a nucleic acid sequence which is different from that published for the
BAC clone
identified as BAC ID NO:A (see Table 1B, column 4). In additional embodiments,
the
above-described polynucleotides of the invention comprise, or alternatively
consist of,
sequences delineated in the same row of Table 1B, column 6, and have a nucleic
acid
sequence which is different from that contained in the BAC clone identified as
BAC ID
NO:A (see Table 1B, column 4). Polypeptides encoded by these polynucleotides,
other
polynucleotides that encode these polypeptides, and antibodies that bind these
polypeptides
are also encompassed by the invention.
[72] In additional specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
sequences delineated in column 6 of Table 1B, and the polynucleotide sequence
of SEQ ID
NO:X (e.g., as defined in Table 1B, column 2) or fragments or variants
thereof.
Polypeptides encoded by these polynucleotides, other polynucleotides that
encode these
polypeptides, and antibodies that bind these polypeptides are also encompassed
by the
invention.
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[73] In additional specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
sequences delineated in column 6 of Table 1B which correspond to the same
Clone ID
NO:Z (see Table 1B, column 1), and the polynucleotide sequence of SEQ ID NO:X
(e.g., as
defined in Table 1A or 1B) or fragments or variants thereof. In preferred
embodiments, the
delineated sequences) and polynucleotide sequence of SEQ ID NO:X correspond to
the
same Clone ID NO:Z. Polypeptides encoded by these polynucleotides, other
polynucleotides that encode these polypeptides, and antibodies that bind these
polypeptides
are also encompassed by the invention.
[74] In further specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of, one, two, three, four, five, six, seven, eight,
nine, ten, or more of the
sequences delineated in the same row of column 6 of Table 1B, and the
polynucleotide
sequence of SEQ ID NO:X (e.g., as defined in Table 1A or 1B) or fragments or
variants
thereof. In preferred embodiments, the delineated sequences) and
polynucleotide sequence
of SEQ ID NO:X correspond to the same row of column 6 of Table 1B.
Polypeptides
encoded by these polynucleotides, other polynucleotides that encode these
polypeptides,
and antibodies that bind these polypeptides are also encompassed by the
invention.
[75] In additional specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of a polynucleotide sequence in which the 3' 10
polynucleotides of one
of the sequences delineated in column 6 of Table 1B and the 5' 10
polynucleotides of the
sequence of SEQ ID NO:X are directly contiguous. Nucleic acids which hybridize
to the
complement of these 20 contiguous polynucleotides under stringent
hybridization
conditions or alternatively, under lower stringency conditions, are also
encompassed by the
invention. Polypeptides encoded by these polynucleotides and/or nucleic acids,
other
polynucleotides and/or nucleic acids that encode these polypeptides, and
antibodies that
bind these polypeptides are also encompassed by the invention. Additionally,
fragments
and variants of the above-described polynucleotides, nucleic acids, and
polypeptides are
also encompassed by the invention.
[76] In additional specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of
one of the sequences delineated in column 6 of Table 1B and the 5' 10
polynucleotides of a
fragment or variant of the sequence of SEQ ID NO:X are directly contiguous
Nucleic acids
which hybridize to the complement of these 20 contiguous polynucleotides under
stringent
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hybridization conditions or alternatively, under lower stringency conditions,
are also
encompassed by the invention. Polypeptides encoded by these polynucleotides
and/or
nucleic acids, other polynucleotides and/or nucleic acids encoding these
polypeptides, and
antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides,
nucleic acids,
and polypeptides are also encompassed by the invention.
[77] In specific embodiments, polynucleotides of the invention comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of the
sequence of SEQ ID NO:X and the 5' 10 polynucleotides of the sequence of one
of the
sequences delineated in column 6 of Table 1B are directly contiguous. Nucleic
acids which
hybridize to the complement of these 20 contiguous polynucleotides under
stringent
hybridization conditions or alternatively, under lower stringency conditions,
are also
encompassed by the invention. Polypeptides encoded by these polynucleotides
and/or
nucleic acids, other polynucleotides and/or nucleic acids encoding these
polypeptides, and
antibodies that bind these polypeptides are also encompassed by the invention.
Additionally, fragments and variants of the above-described polynucleotides,
nucleic acids,
and polypeptides are also encompassed by the invention.
[78] In specific embodiments, polynucleotides of the invention comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of a
fragment or variant of the sequence of SEQ ID NO:X and the 5' 10
polynucleotides of the
sequence of one of the sequences delineated in column 6 of Table 1B are
directly
contiguous. Nucleic acids which hybridize to the complement of these 20
contiguous
polynucleotides under stringent hybridization conditions or alternatively,
under lower
stringency conditions, are also encompassed by the invention. Polypeptides
encoded by
these polynucleotides and/or nucleic acids, other polynucleotides and/or
nucleic acids
encoding these polypeptides, and antibodies that bind these polypeptides are
also
encompassed by the invention. Additionally, fragments and variants of the
above-described
polynucleotides, nucleic acids, and polypeptides, are also encompassed by the
invention.
[79] In further specific embodiments, polynucleotides of the invention
comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of
one of the sequences delineated in column 6 of Table 1B and the 5' 10
polynucleotides of
another sequence in column 6 are directly contiguous. Nucleic acids which
hybridize to the
complement of these 20 contiguous polynucleotides under stringent
hybridization
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conditions or alternatively, under lower stringency conditions, are also
encompassed by the
invention. Polypeptides encoded by these polynucleotides and/or nucleic acids,
other
polynucleotides and/or nucleic acids encoding these polypeptides, and
antibodies that bind
these polypeptides are also encompassed by the invention. Additionally,
fragments and
variants of the above-described polynucleotides, nucleic acids, and
polypeptides axe also
encompassed by the invention.
[80] In specific embodiments, polynucleotides of the invention comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of
one of the sequences delineated in column 6 of Table 1B and the 5' 10
polynucleotides of
another sequence in column 6 corresponding to the same Clone ID NO:Z (see
Table 1B,
column 1) are directly contiguous. Nucleic acids which hybridize to the
complement of
these 20 lower stringency conditions, are also encompassed by the invention.
Polypeptides
encoded by these polynucleotides and/or nucleic acids, other polynucleotides
and/or nucleic
acids encoding these polypeptides, and antibodies that bind these polypeptides
are also
encompassed by the invention. Additionally, fragments and variants of the
above-described
polynucleotides, nucleic acids, and polypeptides are also encompassed by the
invention.
[81] In specific embodiments, polynucleotides of the invention comprise, or
alternatively consist of, a polynucleotide sequence in which the 3' 10
polynucleotides of
one sequence in column 6 corresponding to the same contig sequence identifer
SEQ ID
NO:X (see Table 1B, column 2) are directly contiguous. Nucleic acids which
hybridize to
the complement of these 20 contiguous polynucleotides under stringent
hybridization
conditions or alternatively, under lower stringency conditions, are also
encompassed .by the
invention. Polypeptides encoded by these polynucleotides and/or nucleic acids,
other
polynucleotides and/or nucleic acids encoding these polypeptides, and
antibodies that bind
these polypeptides are also encompassed by the invention. Additionally,
fragments and
variants of the above-described polynucleotides, nucleic acids, and
polypeptides are also
encompassed by the invention.
[82] In specific embodiments, polynucleotides of the invention comprise, or
alternatively consist of a polynucleotide sequence in which the 3' 10
polynucleotides of one
of the sequences delineated in column 6 of Table 1B and the 5' 10
polynucleotides of
another sequence in column 6 corresponding to the same row are directly
contiguous. In
preferred embodiments, the 3' 10 polynucleotides of one of the sequences
delineated in
column 6 of Table IB is directly contiguous with the 5' 10 polynucleotides of
the next
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sequential exon delineated in Table 1B, column 6. Nucleic acids which
hybridize to the
complement of these 20 contiguous polynucleotides under stringent
hybridization
conditions or alternatively, under lower stringency conditions, are also
encompassed by the
invention. Polypeptides encoded by these polynucleotides and/or nucleic acids,
other
polynucleotides and/or nucleic acids encoding these polypeptides, and
antibodies that bind
these polypeptides are also encompassed by the invention. Additionally,
fragments and
variants of the above-described polynucleotides, nucleic acids, and
polypeptides are also
encompassed by the invention.
[83] Many polynucleotide sequences, such as EST sequences, are publicly
available
and accessible through sequence databases and may have been publicly available
prior to
conception of the present invention. Preferably, such related polynucleotides
are
specifically excluded from the scope of the present invention. Accordingly,
for each contig
sequence (SEQ ID NO:X) listed in the fourth column of Table 1A, preferably
excluded are
one or more polynucleotides comprising a nucleotide sequence described by the
general
formula of a-b, where a is any integer between 1 and the final nucleotide
minus 15 of SEQ
ID NO:X, b is an integer of 15 to the final nucleotide of SEQ ID NO:X, where
both a and b
correspond to the positions of nucleotide residues shown in SEQ ID NO:X, and
where b is
greater than or equal to a + 14. More specifically, preferably excluded are
one or more
polynucleotides comprising a nucleotide sequence described by the general
formula of a-b,
where a and b are integers as defined in columns 4 and 5, respectively, of
Table 3. In
specific embodiments, the polynucleotides of the invention do not consist of
at least one,
two, three, four, five, ten, or more of the specif c polynucleotide sequences
referenced by
the Genbank Accession No. as disclosed in column 6 of Table 3 (including for
example,
published sequence in connection with a particular BAC clone). In further
embodiments,
preferably excluded from the invention are the specific polynucleotide
sequences)
contained in the clones corresponding to at least one, two, three, four, five,
ten, or more of
the available material having the accession numbers identified in the sixth
column of this
Table (including for example, the actual sequence contained in an identified
BAC clone).
In no way is this listing meant to encompass all of the sequences which may be
excluded by
the general formula, it is just a representative example. All references
available through
these accessions are hereby incorporated by reference in their entirety.
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TABLE 3
SEQ
ID EST Disclaimer ,
lone NO: ontig Range
ID X ID: of a Accession # s
NO: Z Range
of b
HNHAM52 11 11280301 - 747 15 - AI580306, AA211410, N40468,
761 N48507,
AL080135, and AC004810.
HMMAB49 12 11263021 - 661 15 - D29160, AW 151102, AW406755,
675 AA584489,
AL046409, AI963720, AI284640,
AA635433,
AI358229, AI431303, AW023672,
AI620585,
AL042756, AA613627, AI365988,
AW270258, AW193265, AI732151,
AW270619, AI613459, AW029038,
AI732690, AI783911, AI368745,
AI733856,
AI345681, AI345675, AW340905,
AI570943,
AI267356, AI865905, AW276827,
H23439,
AI345566, F29989, AA779783,
AI281881,
AI090334, AI753365, AA524800,
AW157005,
AI192631, C05694, AI885572,
AA262752,
AW272794, AI350211, AI267450,
AI561060,
AL038936, AI609984, AA176605,
AI613280,
AI028510, AA657835, F36273,
AW167154,
T05834, AI636627, AI291823,
AW088202,
AL048925, AA527209, AI336054,
AW028376, AI598003, AA469451,
AA720582, AW419262, AA955031,
AI345157, AI003068, C75026,
AI039809,
AI345695, AI889440, AI338426,
AI610012,
AA177061, AI254913, AA992126,
AI338808,
AI206392, AI355586, AI610256,
AI270476,
AA598545, AW088616, AA665330,
AI493264, AI628224, AL119438,
AA665449,
AI291268, AI291124, AI355587,
AI312790,
AI863399, AI935827, AI049701,
AC007425,
D87675, AL121655, AC004895,
AF134726,
AF002992, AC006241, AC000353,
D83989,
AC006285, I51997, U18399,
AF015167,
U57009, A39972, AF015147,
U18391,
U18394, U57007, AC005102,
AC004859,
AF015158, AL096701, U02532,
286090,
AC006373, X54175, AC004797,
AC003104,
269591, U63630, AJ011930,
U18387,
AC006953, AL035420, AC004655,
AF015148,
AP000697, 282176, U18393,
U57005,
X54181, X55925, AP000696,
AL049636,
AF015160, X54176, X53550,
AC007395,
AC002301, X54180, AF077058,
AC003046,
AC006942, 284467, AL022238,
U18392,
AL031589, AC007899, U85195,
X55931,
AC005261, AC007999, 297053,
L78810,
AC005568, AC004816, AF107885,
U57008,
AL021940, AC005740, 575201,
AL035079,
AC004685, AE000658, AL049699,
AP000557,
U57006, AC006539, AC005257,
AC004596,
AC002350, AC005722, U67221,
AF207550,
AC004963, AP000135, AC005081,
X74558,
AC005996, AC005480, AC007773,
AP000088, AF064861, AP000272,
AL035423,
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AP000962, AC003109, X54178,
AP001037,
283844, AL049569, D84394,
285995,
AC004754, AC007011, AC005015,
AL049776, AC005512, AC004755,
AF031078,
AP000031, AL121603, AP000048,
AF015166,
298748, AP000300, AL035659,
U67817,
AC006080, AC006207, AC006312,
AC004983, AC005370, AL049874,
AF015162,
AF030876, AC004854, AC020663,
AL050318,
AL034549, AC005736, AC004502,
AC005399, AC004659, AC007397,
AL021155, AF190465, AC004019,
AL122023,
AL022302, AL096862, AL132992,
AC004485,
AC007043, AL033543, AC005288,
AL109759, AC005668, AP000194,
AC004821,
AP000008, AC005209, AP000704,
AC005527,
AP000115, AP000113, AP000045,
AL078477,
AC004382, AC005599, AC007227,
AP000104, AC007200, AP000513,
AC002073,
AL021546, AC004033, 284480,
AL096767,
AC000052, AC002316, AL135744,
AC005755, AP000348, AL049830,
AC005488,
AL008735, AL035450, AC002480,
AF015149,
270289, AL031390, 293244,
AC005007,
282208, AC007284, AC005764,
AC004491,
AC004408, AC005476, 299716,
AC007283,
AP000556, AC005757, AL117352,
AP000552,
AL021154, AL035458, AC005076,
AC005011, AC009516, AC000097,
AC007731, 282900, AL132987,
269705,
AC005562, AC007308, AC004531,
AC005808, AC006077, AC004838,
AL080243, AL050312, AP000280,
U80017,
AP000213, AL022163, AC005412,
U18390,
AC004129, AP000567, AC005367,
AF015155,
AL117344, 273361, AC005759,
AC005037,
AC002457, AC004973, AL031720,
AP000961,
AC002470, and AC006064.
HRDBT72 13 11275621 - 865 15 - AW271904, AI696962, AL138455,
879
AA680243, AW088846, AI369580,
AL042756, AW237905, AA651639,
AA610491, AI867058, AI358712,
AI732120,
AI431303, AW151105, AI754253,
AI334443,
AA634786, AA469327, AW069769,
AW069227, AL046409, AW302315,
AL119691, AL040054, AI963720,
AI755214,
AI753113, AI345157, AI368745,
AW410354,
AI061313, AA574442, AI754105,
AI110844,
AI358384, AI754567, AA521399,
AA521323,
AW327624, AA904275, AI887235,
AL037683, AW021583, AL038842,
AW103406, AW275971, AI821931,
AA581903, AA644090, AW303196,
AI054333, H05940, AI754336,
AW301554,
AW301350, AA128592, AW028429,
AL042853, AI791150, AI821714,
AI792133,
AI791913, AI732151, AW084445,
AI801482,
AW 193265, AI244127, AI679782,
AI267818,
AI305766, AI633025, AI350069,
AW103758,
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AW340905, AW166611, AW327868,
AA720702, AA610509, AW020088,
AI754037, AI017251, AL042753,
AI272052,
AW189068, AL038606, AI821785,
AI133164,
AI311226, AI521S25, AI457397,
AI753365,
AW274349, AI610920, AW302048,
AA584484, AA714011, AA630362,
AL120343, AI732671, AI821494,
AI613280,
AI133102, AI821467, AI094787,
AI281881,
AA833875, AA833896~ AA167055,
AI633168,
AW068596, AI254913, AW131457,
AI133029, AL118991, U73023,
AL049869,
AF146191, AC005666, AC004520,
AC005019, 275888, AC005184,
AC004477,
AC006077, AC004019, 275887,
284489,
AL022323, AC004257, AP001053,
AL049699,
AC003663, AC004878, AL049713,
AC005057, AC005015, AL021154,
AL050307, AL109798, AC005224,
AC011311, AF134726, AC004858,
AL121603,
AC005829, U80017, AL096791,
AL008631,
AC005225, AC005412, AC007677,
U85195,
AF109907, AC004139, AE000658,
AC004685,
297653, AC005921, AC006111,
AC002073,
AP000502, AC004087, AC002476,
285987,
AC004999, AC005013, AC005939,
AL031767, AC002369, AL021579,
AC004002, AL133448, U62293,
U95739,
AP000493, AC005772, AL031447,
AL031003,
AL031670, AC009044, AC005874,
AF134471,
AF050154, AC002119, AF196779,
AF165142,
AF091512, AC015853, AF117829,
AL022328,
AC006299, AL049780, AC004655,
AC005562, AC007298, AB023049,
285986,
AC004797, AC005031, AL035461,
AC005089, D83989, AC006509,
AL121658,
AL049552, U02532, AC004066,
AC005295,
AP000065, AC002558, AL133245,
AC004893,
AC007842, AC002086, AC006001,
AL050318, AC004150, AC004003,
AC002314, AC007225, U89335,
293244,
AL021393, AC004909, AL121595,
AC005164, AC006121, AC005726,
AC005066, AC006449, AP000356,
AC004765, AL035420, 269714,
AC005919,
AC009509, U78027, AP000114,
AC004882,
AC003006, AC004673, AL022476,
AL034417, AC006088, AC006314,
AC004656, AL034429, AC005060,
AL035455, AL035422, AL049646,
M30688,
AC007685, AC005625, AL031659,
AC006530, AC005943, AC006372,
AC005050, AC005696, U91326,
AC008115,
AC007030, AC005620, AL049829,
AC004905, AP000511, AL049759,
AC007052,
AB023048, 282202, AC006262,
AC006388,
AC005663, AL096776, AF042090,
AL034406,
AC005330, AP000552, AP000501,
AC004913,
AC004859, AC006511, AC005365,
284469,
341
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL133246, AP000008, L44140,
AC007055,
AL049757, AC002559, 297181,
U95740,
AC002301, AC007461, AC006011,
AL121652, AL031685, AC007637,
AC007207, AL021808, AC005081,
AL096701, AC006571, AC005074,
AF107257,
AC004470, AC006285, AC006443,
AL096702, AC004815, AC005215,
AC002531, AC004752, U02531,
AL032821,
AC006115, AC008394, AC016025,
AP000030, AC005377, AC002542,
AL1216S3,
AC005049, AC005254, AL109627,
AL031654, AC004522, AC002470,
AL022313, AC007057, AC005256,
AL096712, X54486, AL022329,
AC005210,
299495, AL024507, AL009181,
AL021391,
AL031230, AC008009, AC005088,
AC004686, AC006323, AC007688,
AD000092, AL109952, AL035587,
AC003043, AL132987, AC005746,
AC004941, AC009501, AC005606,
AC004263, AC006946, AP000518,
AL035697,
AC003108, AC000025, AC004972,
AC007283, and AC006071.
HE2FR50 14 11274661 - 662 15 - AI961240, AA827821,, AI718802,
676 AI572903,
AI379116, AI808413, AW262991,
AI141317,
AA446001, AA419448, AW338468,
N66499,
AA954259, AW 151742, AA279131,
AW268151, AA421293, AI417463,
AA329700, AA832485, AI088138,
AA705264,
AA150283, 828937, AA421397,
AA147276,
AA150385, and AF129534.
HLHDR39 15 11246591 - 488 15 -
502
HSIDS82 16 11785501 - 735 15 - AW296375, and AA347128.
749
HSICX21 17 12270791 - 923 15 - AA583390, AC004551, AL031650,
937
AC005622, AC002527, AL049779,
and
AC005531.
HCDAJ15 18 11361161 - 828 15 - AI619583, AA771958, AL038713,
842 AI610326,
AW102963, AW268051, AI382347,
AI349829, AW268787, W36297,
AI254827,
AI598077, AI570164, AI249995,
AI193408,
AI220812, AI076479, 884318,
AI685116,
AI865581, AI378966, AA299156,
AI186380,
AI813836, AA344409, AA826143,
AA890652,
AI003789, AI376849, T50788,
AI591332,
AI457143, AI310239, AI926394,
AI866116,
AI336584, AW301368, AI345632,
AI033935,
AI251249, AI054162, AI340720,
AI282577,
F33837, AI793142, AI377100,
AI921626,
AA852059, F17026, AL040818,
AI928570,
AI345549, AW339583, AA468571,
AW139132, T06365, AI375417,
AI088245,
AI540098, AI872191, AI369914,
AI862212,
AI805962, AI309322, AA446110,
AA548061,
AI053905, AI252097, AW148973,
AI887321,
H89662, AI678745, AI285660,
AA551109,
AA203291, AW085676, AI621138,
AI051940,
AI333568, AA748658, C17730,
AI933550,
N26697, AI191894, 236956,
AI971014,
342
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA962220, AW243708, AI611997,
F17041,
AI783731, AI588913, AA852074,
AI356342,
W31733, AI356348, AI453790,
AI051341,
AL040846, AI758697, AA069204,
AA620331,
AI619818, AI890953, AW272376,
AA847621,
AL043725, AA359513, AI803354,
AA223246,
AA877295, AI147839, AI242057,
AI032071,
AA779937, AA570297, H01156,
AI810990,
896586, AI564253, AI439415,
884298,
AI282349, AA132716, AW084901,
AA907819, T78394, AI813517,
AA904946,
AA601392, AW168798, AI818750,
AI818764,
AI683220, AI362498, AI028382,
AA328438,
AA972363, AA459350, AI382215,
AW090395, AI244642, AI628308,
AA565837,
AA082049, AL133942, AI925647,
AI246569,
AI610776, AI421079, AA326171,
AL036183,
AI468037, AI354287, AI140677,
AA635571,
AL118834, W37263, AI933966,
AI538654,
875627, AW193992, AA635562,
AA584498,
AI367384, AI264673, AI027714,
AA368610,
AI858607, H71710, N66283,
AA467904,
AA467957, AI652064, AI869945,
AW275729,
AA767353, N74502, AI696940,
AA679855,
AI734095, N53830, F18230,
AI749571,
W56878, AI197934, AA347740,
AA811111,
AA130476, AW157413, AA223830,
AI479035, AI364461, AA058988,
AI540401,
AW167452, F16584, AI948934,
H71074,
AA613244, AA128992, AL109847,
AC005053, AL023875, AC002480,
AC005858, AL049545, AC005040,
AC005593, AC004081, AP000966,
AC000048, AL031286, AC006926,
AC006063, AL031407, AC004664,
AL035610, AC007032, AC005881,
AC007228, AL035688, AC006973,
AC005899, AC004869, AB020874,
AC006054, AL121578, AL031176,
278022,
AC004519, AF049895, AC004551,
AP000961,
AC004066, AL121577, AF188024,
AC004992,
282195, AC005181, AC005336,
AC002536,
284816, AC003991, AC005553,
AC004073,
AC004931, AC005196, AF123462,
AC004891, AC005913, AL034408,
292844,
AC005681, AC008109, AL080312,
AF003529,
AC006948, AL117337, AC007514,
AF205588,
299569, AC002288, AL121580,
AC007198,
AC007968, AC004741, AL079305,
AL021940, AC004052, AF044083,
U95738,
295400, AL049858, AC007501,
AC000114,
AL021921, AL009173, AC009514,
AL109618,
AC007385, AC003661, AC006239,
AL022577, AL049734, AL078623,
AC004388,
AL133500, AC010349, AC005145,
AC007262, AC010722, AC004875,
U91319,
AL035633, AL022718, AL033525,
AC007425,
AP000071, AL022719, AL109758,
286061,
AC002065, AC006461, AC006502,
343
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC005534, AF117829, AL031671,
AC005537,
AC004216, AC008124, AL031653,
AL022099, AC004784, 268326,
AL035563,
AC008498, AJ006345, AL121767,
AL024507,
AL008633, 268871, AC004911,
AC006016,
AC004S62, AC003693, AC005090,
AL096866, AC006257, AC007435,
AL022164, AL023806, AC006455,
AC006346, AJ229042, AF051934,
AC004768,
AC007284, AC006454, AF008243,
AL049867,
AC004887, AL049823, AF093117,
AC004744,
AC009069, AC010183, 276735,
AC008174,
Z982S5, AL078643, AC006023,
295889,
AC007376, AL031000, AL080239,
AC006987, 283827, AL096709,
AC007630,
AC003106, AF017257, AL034377,
AC007786,
AP000473, AC011594, AL022151,
AL008987,
AC006353, AC010209, AC009239,
AC005752, AC005146, AC007012,
AF130343, AL022724, 284470,
AC006381,
295325, AC006456, AL133321,
AC004385,
AC007370, AC004384, AC003977,
AC009405, AC005031, AP000475,
AC004215, AE000660, 298304,
AC004184,
AC006143, AL136297, AL034406,
AP000160,
AL117375, AL078639, AC008014,
298051,
AC006924, AL031673, AC009225,
AL035555, AC002086, AF165175,
U80017,
AL080272, AP000018, 293928,
AC002523,
AC005319, AL049642, AC005273,
AC008275, 295328, AL021026,
AL009175,
AC006572, AC006383, AC009241,
AL021330, AC005187, AC004061,
AB019440, AL031665, APOOOlS7,
AC009721,
AC004225, AC006313, AC005227,
AC006195, AC005284, AL022720,
AC002529, AL079303, AE000659,
AC006989, AL109621, AC005023,
AC005017, AL035409, and AC004010.
HSNAH21 19 12004871 - 170 15 - AI074638, AA156897, AA405746,
184 AI288884,
AI142828, AI434997, AA464691,
AI079347,
AI141600, AA558999, AI417262,
AA524307,
AA729535, AA492487, AW453078,
AA436613, AA923317, AA746965,
AI142582,
AA424901, AA156817, AI339241,
AI042516,
AI097311, AI924831, AI435356,
AI743842,
AW023128, AA424767, AI751251,
and
AC004616.
HBZSH19 20 12199631 - 454 15 - AI707851, AI752914, AI610625,
468 AI269269,
H16800, AA223243, AI192616,
AA720665,
AW104357, H48475, AA576582,
AW009078,
and AA037054.
HWBCQ57 21 11286041 - 981 15 - AW404796, AA419168, AW405212,
995
AW405771, AA858023, AW402670,
AA482466, AW131668, AW406412,
AW402410, AW406310, AI905912,
AW406867, W87573, AI523647,
AW406295,
AI627929, W01611, AW406262,
AI817360,
AA634860, AW406388, AA165543,
344
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW368560, AA131654, AW403503,
AI889774, AA635838, AW170583,
AW403480, AI913770, W87428,
AA165510,
AW403818, AA417879, W37301,
AI433246,
862321, AA564957, AA746256,
AA652656,
AI554248, AI141914, AI097155,
AI000769,
AA703160, AI084034, AI149461,
AI803471,
AI469262, AI274173, AW404237,
AA622265,
H92391, AI193402, AA708855,
AW072121,
AI358266, T63635, AA360864,
AA348102,
H83811, AI831123, AI865230,
AI250702,
AW337397, 862322, AA159668,
AI025871,
AW403090, AA131588, AA679851,
AA978343, H92332, AI719939,
AI141141,
T63837, AI336045, AA908772,
N71267,
AA367085, AI214586, AI758717,
AA159773,
AA405114, AI347065, AA381553,
AI193894,
AI709196, AA887979, AA918569,
N40858,
AI633727, AW407118, W01461,
AA775022,
AI347068, AW405872, T66015,
AA878538,
AA318565, AI701743, AI868933,
AA862420,
T65859, AW406039, AA173991,
AI819482,
AA385676, AI573045, AI281412,
AW007639,
AW016654, H25099, W37302,
AW404245,
AA411017, T63945, AW371963,
AW392485,
AA995292, AA362205, AI344688,
T29163,
AI375185, AW388120, AW388107,
AW375541, AW388113, AA954002,
AI078594, AA346471, AW377763,
T28717,
AW375539, T72429, AA603100,
AW388115,
AW405063, AI200165, AA922753,
X00452,
M34996, M20431, M33906, M26041,
X00370,
U92032, 284490, 284489, M20506,
M17236,
M29616, M29615, M17237, X00033,
U77589,
M93430, U42407, M17847, M11124,
L34085,
D50045, L33909, L34084, L34083,
M29939,
M17846, M16995, 540624, L34082,
L42625,
L34086, M93431, J00199, M29938,
AF037314, L34094, L34090,
L34088, L34089,
L34087, L34352, L34091, L34092,
L34093,
D50048, D50047, D50049, M15557,
AF012768, M74910, M74908,
M74909,
M74907, Y07942, Y07944, 226591,
Y07943,
K01923, D50046, AR033964,
AR033963,
AF129124, AR033962, AF129118,
AF129117,
AF129120, AF129121, 581351,
X00455,
U91907, M59802, M95170, M34999,
AF109734, L12916, U47858,
L12915, L12914,
L12917, 569985, E01702, I40296,
AF126253,
M18935, AF038155, M76189,
U85035,
AJ130870, U44785, U44787,
L12922,
AF031277, U03580, U03594,
U03581,
U44789, U44842, U75455, L12921,
U47857,
U03584, U03582, U44786, U44790,
M95728,
Y09968, U44788, U61400, X71613,
M34997,
X71614, L12918, M76218, L12920,
M76228,
M76201, AF091334, AF110840,
M76187,
AF110836, U97555, M76200,
X71615,
M76199, D88582, D88647, D88550,
345
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AF110843, U03675, M76212,
D88580,
M76195, AF110835, M76223,
and AF091332.
HCFAT05 22 5921181 - 478 15 - U96110, L23499, M38217, M85217,
492 M55515,
U38240, U38182, AR050270,
and U45979.
HMWIN49 23 11954651 - 482 15 - AI037856, AA542997, AI311400,
496 AI566802,
AA310786, AA532689, AA398908,
AA316357, AI311528, AI422657,
AI589506,
AA352183, W68226, AA320005,
W68225,
AI720450, AA935679, AA689231,
AA176451,
AI474407, AI073958, AI208100,
AA541796,
AA363414, AA985268, AW163567,
AL038843, AW051112, AI300842,
AW381682, AA161338, AA922650,
AA176457, AA374424, AA094843,
N87306,
AW405970, AA425597, AA689508,
AI267756, AW341775, AA092969,
AA320778, AA745933, N28607,
AA247451,
AA876344, W32907, AA652657,
AA627101,
AW 137988, N47392, AI989393,
AA863326,
N89372, AA933653, 220829,
AA402513, and
A75039.
HOECV83 24 11263211 - 387 15 - AI140321, AI270499, AI810183,
401 AA814586,
AI910862, AI753510, AI199086,
AI862658,
AI367789, NS1917, T16520,
AA969919,
F03901, W07603, N56197, and
AL050087.
HWACV74 25 11652631 - 1745 15 - AI762815, AI637581, AI702097,
1759 AW025622,
AA814968, AI004348, AW 193426,
AI635627,
AW081066, AI569925, AI933804,
AW276794, AI864500, AA483606,
AA570740, AA568204, F09355,
AW019964,
AC007011, AC007637, AP000036,
AL049869,
AL008719, AC004962, AF031078,
AF030876,
AC004686, AF003626, AL135783,
AC000353,
AC008154, AC005094, AP000245,
AP000128,
AP000206, AC005874, AF134471,
AL031228,
AC004470, AC004797, AC005377,
AC0069S2, AC006390, AL096703,
AC005900, AC003663, 295889,
AC003037,
AC002352, AC003074, AC004912,
AF015262, AJ229043, 268164,
AC005915,
AC004887, AL022098, AL031733,
AC007298, AC007021, AL034417,
AL009181, AC005291, AL139054,
AC005244, AC002530, AC007563,
AC005013, AC004778, AL078638,
AL078584, AC004890, AJ229042,
AC004664,
AC007263, AC007363, AC002465,
AC005284, AC004383, AL022724,
AL035420, AL121576, AL049611,
AL049839,
AP000032, AC004822, AC007279,
AL031577,
AC000393, AC005531, 293020,
AF064858,
AC005071, AC003029, AC002425,
AL031584, AC003104, AL096701,
AL078581,
293244, AC005566, 297181,
AC005520,
AC005736, AJ22904I, AC007392,
AL122003,
AL080277, AP000088, AC007425,
AC005081,
AC007707, AC005368, AC002492,
U95740,
AC004216, AP000250, AC004963,
AC005529, AC006449, AC007055,
346
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC005411, AC006123, AC006538,
AC007993, AL080242, AC005378,
and
AC004983.
HCHMV63' 26 11948311 - 135215 - AA528091, AI937130, AL043928,
1366 AA512928,
AI003767, AI950845, AI68I293,
AW020408,
AI126197, AW 189101, AA421192,
N56993,
AI498013, AA278851, AI081289,
W76552,
AA285337, AI568488, AA609588,
W74357,
AA417379, AI272841, AI634849,
AI082525,
H72715, AA862669, AA370112,
F37679,
848578, AA508735, 818652,
809304,
AA993015, T73701, AW193459,
AW027819,
AA508168, AI383524, AA298483,
AA428290,
AI608919, AI916400, AA360685,
AI001776,
AW189612, 809199, H97957,
AI371477,
848679, AA706851, AA766418,
AI222565,
AA565335, AA548319, AA428723,
N73552,
T73726, 873134, 873194, AA298688,
AI349777, AI266766, AI251698,
AW274324,
AI254621, and AW268781.
HCWKB72 27 11940551 - 166715 - AA828260,
1681 I141283, AA725020, AA193339,
A
AA506758, AW235758, AW205256,
AI805548, AI805364, and AF048977.
HFPCT53 28 11623961 - 104915 - 837669.
1063
HDTBW62 29 12228291 - 301115 - AW237401, AI950812, AW131361,
3025
AW104061, AI332421, AI571939,
AI569994,
AW392488, AA506012, AI969698,
AI970981,
AW392477, AA218990, AW392476,
AA470145, H29400, AA938113,
H44981,
AI709076, 836314, AA380279,
F07555,
AW149266, AA639967, AA336314,
AI869822, AA327744, AI553704,
AA741222,
849246, D61949, T10753, and
T82938.
HEFMB30 30 10372951 - 423 15 - AI81327I, AI796347, AI459195,
437 T71268, and
AA702812.
HMSKF13 31 708207 1 - 387 15 - AA148393, AC023891, and AC023891.
401
HAHDI40 32 710790 1 - 642 15 - AI979303, AI627654, AI762005,
656 AI627344,
AI308065, AW138446, AI636384,
W67420,
AI825690, AW025834, AI190111,
AI921024,
W67304, AW082705, AW204142;
arid
AF086254.
HAPOR59 33 11334141 - 430 15 - AW407636, AA805331, AA609056,
444 and
AC007444.
HFCAG94 34 11263681 - 100715 - AA338681, AI634187, AW069227,
1021
AL079734, AI457313, AI004591,
T50676,
AI206841, AA629412, AI469599,
AI912401,
AI189682, AI978782, AA568314,
AA879053,
AI962030, AA021561, AA559330,
AI491765,
AW419389, AI096421, AW 117704,
W32376,
AA176605, AI792575, AI054398,
AA493110,
AA600202, AW083102, AA828637,
AI908093, AW117723, AI431513,
AA610433,
AW082104, AA773463, AW081485,
T47138,
AI866580, AI653776, AI620992,
F24745,
AW083934, AA456924, AA550989,
AI280504, H29914, AA535216,
AA572974,
AA056250, AA219349, AW089950,
AC002477, AP000557, AC007182,
347
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC010205, AC005409, AP000556,
AC005844, AC006312, U78027,
AL050307,
AL049569, AC004814, AP000359,
AP000045,
282215, AC003006, AC005043,
AC005324,
AL096701, AL022396, AC004382,
AC005102, AF205588, AF095901,
AC005225,
AB003151, AC016025, AL035071,
AL034548, AC008123, AC006441,
D88268,
I34294, AP000113, AC007637,
294802,
' AC007546, AC005971, AL117344,
AL021977, AL109628, AC007731,
AF130343,
M87889, AC005500, AC005920,
AC003667,
AP000299, AC004907, AC004149,
AC004816, AC005014, AC016026,
Y10196,
AC007298, AC005559, AF207550,
AC004408, AC002476, AC005189,
AC004966, AP000501, AP000212,
AP000134,
283840, AL078638, AL049843,
AL023283,
AF134726, AL049780, AL035417,
284488,
AC002310, 283844, AC002350,
AC005231,
AL121658, 281364, AF187320,
AC007055,
AL031228, AC006023, AL137191,
AC005215, AC004000, AP000030,
AC006449, AC004771, AC000028,
AC004068, AC007308, AC001228,
AC005399, AL031602, AC006530,
AC005082, AC004491, AL022336,
AL049874, AC005015, AP000115,
AC007225,
AC002369, AF053356, 297183,
AC002312,
AC002553, AC004656, AL031672,
AL031005, AC002375, AP000252,
AC004605,
AP000558, AC005619, AP000690,
AC006084,
AL122020, AC002504, AL008730,
AC000086, U81031, AC002115,
AL133445,
AF124523, AC004224, AC003043,
286090,
U89335, D88270, AC002128,
AC009516,
AP000065, AC006480, AC005933,
AC004543, AC006948, AP000362,
AL021808,
AC002546, AF217403, AC000353,
AC004883, AL021453, AC008056,
AL079342, AC002544, AC005363,
284466,
AC002070, AL033527, AC004973,
AC003070, AL117330, AC005859,
AC006468, AC005071, AP000358,
AC005049, AL031257, AC007686,
AC003692, AL035681, AC006101,
AL049759, AC004686, AL034429,
AC007565, AC005756, AB023049,
AL132668, AC007878, AC002463,
AL031289, AC005821, AL035683,
U75285,
AC004878, AL139054, AC003690,
AC003101, AC000029, AL031431,
AL023513, AF111168, AC005516,
AC005846,
AL031315, AC004997, AL034420,
AC004106, AC005566, AL034402,
AF024533,
AC005837, AL008726, 284487,
295331,
U62293, AL034555, AL031291,
AC006285,
U91326, AL035587, AP000692,
AC006511,
AL035086, AL049872, AC000118,
348
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC005585, AL021707, AC007664,
297056,
AC004834, AL031685, AC005839,
AL078624, AC002287, 298941,
AC002994,
AL031594, AC006139, AC003108,
AL050341, AC004999, AC004882,
AC002316, AC002425, AC008134,
AF045555, AL035249, AC005081,
AC006965,
AC005531, AC006071, AL034423,
AC005822, AC007160, and AC003684.
HSPAB58 35 11247461 - 510 15 - AI718112, AA702244, and H64345.
524
HLHCT68 36 7647451 - 425 15 - 891150, H67895, AI205078,
439 225012, C05212,
230134, AA194359, AC010344,
AC010344,
AC010344, AC008496, and AC008496.
HBIBF78 37 11279911 - 127815 - 867200.
1292
HLJDQ79 38 11274721 - 597 15 - AI309853, AI279001, AI346808,
611 AW262866,
AA845409, AW069609, AW269884,
AI222714, AI814396, AI090041,
AI261831,
AW026873, AI926707, AI189010,
AI923918,
AA4.18804, AI696996, AI355341,
AA682734,
AI082019, AA946929, AI276623,
AI078444,
AI283259, AA948662, W86206,
W19270,
AI026034, AI198813, AA639042,
860830,
AI800667, AA845895, AI797428,
AI797924,
AA876070, AA223983, AI802422,
AI268914,
AW072253, AI040868, N75887,
AI033779,
AI080435, AA847577, AA972508,
W19281,
AI765686, AA632071, AI499971,
N33524,
W04633, N22110, H16580, AI738872,
AW022940, AA628361, H88786,
AA558544,
AA834982, AI079661, AA580038,
N50677,
AA835537, AI375877, H07082,
AA864215,
W31728, AA709294, AA487933,
AA487934,
H13730, 845566, H68554, AI922644,
H89004,
AI244053, 849016, AI708537,
AA247866,
N74694, AI950614, AA526994,
W25374,
W25452, AA233297, AA418977,
AI497736,
AL079657, and L26335.
HNHE 39 7855801 - 117 15 - AC024653.
86 131
HWAAE95 40 11349321 - 185515 - AI452836, AW117860, AI865213,
1869 AI921706,
AI358384, AA720582, AW151541,
AL041375, AA747375, AI755214,
AI754567,
AI370475, T05834, AI754105,
AA809125,
AA493808, AI078409, AI524453,
AI521525,
AA365586, AA584489, AA533408,
AA468322, AI280535, AI859834,
T51832,
AA604843, AW238712, AW020150,
AA829036, AA584765, AA526414,
AL038842, AI800426, AI860423,
AA665645,
AL044489, AL042113, AA523812,
AW075979, H93293, AI801563,
AI249688,
AA584603, H05940, AA812058,
AAOI3168,
AA410788, AW103006, AA679946,
AA644090, AA908329, AA634209,
AA019973, AI017251, AI581486,
AW271917,
AW 118529, AI377413, N25304,
AA632845,
AA570441, AI570943, AA262752,
AA829065,
AA90421 l, AA420723, AA665449,
AA779783, AW238127, N39388,
AA904275,
AA526424, AI751180, 298743,
AL049869,
349
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AD000092, AC005874, AF134471,
AC002045, AP000301, 283826,
AL049694,
AC005899, AC005913, AC004832,
AC007437, AL049843, AP000045,
AC007350,
AC004009, AL049589, AC006251,
AF038458,
_ AC004464, AC006039, AC005527,
AC002416, AC008123, 283846,
AP000053,
AP000168, AP000121, AC020663,
AC005776,
AC004263, AC005529, U95743,
AL035610,
AC005005, AL049766, AC005081,
AF196972,
AL034420, AC005755, AL031622,
AC004841, AC002126, AC003109,
AC005599, AC006312, AC009181,
AC005304, AC004817, AC005666,
AC007386, AP000238, AC002316,
298256,
AP000094, AL031297, AP000113,
AC002039,
AC003098, AC005255, AL031281,
X55448,
AC003043, AC005180, AC002544,
AC000120, AC004743, AL031427,
AC007537, AL035420, 299128,
AC008012,
AL139054, AL050348, AL031722,
AP000502,
AL008631, AC004225, AF088219,
AC005004,
AC007993, AC007193, 299754,
AC004382,
AC004874, AC006597, AF111169,
AC009247, AC006057, AC007377,
AP000065, AC004755, AP000692,
AC003101,
AC005019, 293244, AC003956,
282190,
AL022323, AL034351, AC005726,
AC005747, AL109656, AC004022,
AC005670, AC007225, AC009498,
AL121576, AC005206, AP000152,
AC004754,
AJ011712, AP000512, U82828,
AF001549,
AC002044, AC004659, AC005015,
AC005667, AP000359, AL031587,
AB015355,
AL021978, AL034423, AP000326,
AC003042,
L78833, AL022320, AC008928,
AC005553,
AC016025, AP000300, AC005548,
AC004858, AL024507, AF045555,
AC004000,
295115, U95090, AL109627,
AL022721,
AC004984, AP000169, AP000122,
AP000054,
AF111168, 298200, AC005736,
AC002094,
298752, AC005060, 293017,
AC007283,
AC007637, AC005037, AC002347,
AL096712, AL133448, 298742,
AL109733,
AC000075, AC005070, AC006088,
AC004921, AC006023, AC005971,
AP000289, AC005306, AL049709,
294044,
AC005516, 249154, AC002400,
AC008040,
AP000042, AP000110, AP000689,
AB004907,
AP000103, AC008101, AB019438,
AL133245,
AC005377, AL078581, AC006449,
AL080243, AC004174, AC004799,
L44140,
AC005006, AC009946, AC009248,
AL009181, AC002381, AL034548,
AL008582,
AC006271, AF207550, AL022328,
AP000135,
AL022326, AC007263, AC004525,
AC004834, AL031283, U78027,
AC003035,
AP000011, AL021877, AL022316,
AC002394,
AF020515, AP000031, AL079295,
AC005247,
350
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC006373, AL121652, 271183,
AC005833,
AL023281, AC007666, AP000501,
AC004595,
AL035415, AC004967, AP001038,
AC009516,
AP000215, AC015853, AL137191,
AC007226,
AC004655, AC008984, AC006948,
Y14768,
AC005356, AC004383, AC008062,
AC006013, AB014078, AP000514,
AP000555,
AL049871, AC006285, AC004408,
AC018633, and AF134726.
HLMAC70 41 11276901 - 922 15 - AI890962, AI285687, AW367205,
936
AW296559, 855594, U91543,
and AF006515.
HTLAQ18 42 8117921 - 649 15 - AA442624, AI382107, AA009701,
663 and
AL133054.
HTOIA82 43 8443191 - 401 15 - H04212, AC012446, and AC012446.
415
HUVHP54 44 11996091 - 191915 - AW360965, AL036039, AI951240,
1933 AI765501,
AA211734, W63553, AW188545,
AA112034,
AI982523, AA316041, AW271852,
AI054414,
AL138265, AI110760, AA081138,
AI457389,
AL042905, AL042906, AA211024,
AL037632, AW157180, U51704,
AL138254,
AA297145, AL036038, AA601230,
AA577824, AW131249, AL044339,
AL044340, AA071151, AW088689,
AA633892, AA708108, AA526759,
AF034176, AW409807, AA742815,
AI694178, AA527963, AI038990,
AL042539,
826717, AI907046, AA486896,
AA736713,
AI863046, AI583978, AA618412,
AW157616,
N23913, AI076616, 826941,
AI951863,
AW008212, AA577878, AA634991,
AI799545, AI125167, AI355495,
AA046906,
AA157876, AA504951, AL041895,
AW 188427, AW 102955, N23097,
AI816537,
AA287618, AI800168, AI800180,
AI053623,
F28204, AI310464, AL 120269,
AA60I278,
AI468006, AW089861, AA317168,
AI821044,
AI871691, AA230075, AA470582,
AL047481,
AI631119, AA224525, AA598663,
AA482323,
AA908857, AI346122, AI744188,
AA470577,
AA704101, AA653823, AA610271,
AA126635, T63408, AW103509,
AA629679,
AW248523, AA613164, AA223932,
AA019793, AA569600, AI445934,
AL044489,
AL120008, AA568314, AA206044,
AA284247, AA580560, T74524,
AA834799,
AI561210, AW169057, AI929825,
AA481760,
AA904211, AA525807, AL042891,
AL048901, AA302628, AA838140,
AA782322, AI755057, AA551204,
AI884522,
. AA632581, AA533025, AL046746,
AA130647, AC005619, AC005081,
AL121603, AC004858, AC006449,
AP000117,
U89337, AC004099, AC005231,
283844,
AC005180, AC006111, AP000512,
AC002303, AC005488, AL031311,
AC005015, AC003109, AC005736,
AC002418, AC005821, AP000208,
AP000130,
AL021393, AC004813, AC011311,
AC006285, AC007686, AC004386,
351
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL031680, AC003692, AC000025,
AC005722, AC007242, AL132987,
AC004760, AC005529, AC005527,
AL035071, AL021918, AC005225,
AL031432,
AF207550, AP000050, AP000555,
AF196971,
AP000501, AL035443, AL109798,
AC008498,
AC005484, AL078581, AC006011,
AC007546, 283840, AC005924,
AC007537,
AC009247, AC006001, AC004895,
AP000313, AL022318, AC005220,
AC006480,
AC005399, AL121653, AC006064,
AC006241, AC006101, 298304,
293023,
AC004150, AF196779, AC005746,
AL080243,
AL135744, AP000553, L78810,
AC004832,
AC004929, AL021154, AC016027,
AL009181, AL022163, 285986,
AC004686,
AC002301, AL035079, AC005264,
AC006965, AC005971, U95739,
AC004638,
298742, AL024498, AL049776,
AL034423,
AC004491, AC004953, AC002425,
AL049872, 294801, AC006430,
AC004865,
AC007057, AL022336, AP000113,
AL022326,
AC004531, AP000045, AC004000,
AC005007, AC005089, AC005881,
AL031283, AC005486, AC004253,
AC016830, AC002369, 285987,
AC005829,
299716, AC005102, AC004890,
AC007011,
AC005535, AL096701, AL022316,
AC00773I, AC007066, AC003101,
AF045555, AC005412, U15177,
AC007055,
AC002470, AC003108, AC005500,
AJ246003,
AL139054, AC005778, U85195,
AP001053,
AC008273, AC008044, AC002477,
AC006538, AC005099, AC007292,
AL022396, AF111167, AC002430,
AC007919,
AC004383, AL049829, AC005696,
AC005520, AC000353, AC004522,
AP000300, 298044, AC006511,
AC007676,
AF024533, AC002565, AL031584,
AC005189,
AL121658, AL049759, AL050318,
AC004991,
AC005049, AL022721, AP000030,
AC007384,
AC006211, AE000658, AL118516,
AC004973, AF196972, AC008115,
AC003663, AC005884, AC005562,
AP000557, AL022323, AC002544,
AC005755,
Y14768, AC004963, AC005251,
AC007030,
284487, AC004079, U95742,
AC007308,
AC009509, AL035086, U89335,
AF001550,
AC007690, AC005005, AC006966,
AF003529, AC004854, AC005899,
AC004242, AC004922, U95090,
AL133289,
AC007225, AC004797, AC002128,
AL096791, AF064861, AC006006,
AC005229,
AC006512, AL031005, AL049780,
AC007227, AC005874, AF134471,
AC005071, AC004263, AR036572,
U91328,
AC004602, U47924, AC004815,
AL022313,
AC007664, AC002351, AC005940,
AB003151, AL050307, AC004876,
352
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC007216, AF196969, AC006125,
AC006530, AL035422, AC005328,
AL121652, L44140, AP000270,
AP000691,
AL021707, AC007240, and AC004703.
HEOPE58 45 851009 1 - 463 15 - AL078634, AP000117, AP000194,
477 AP000313,
AP000050, AL078634, AL078634,
and
AL078634.
HE8AE26 46 11361291 - 105715 - AA331521, AA331463, AC004878,
1071
AC005071, AC006480, AC002551,
. AC004084, AC005088, AC006014,
AF030453, AC005488, AC005184,
AC004447, and AC006001.
HHFO084 47 857780 1 - 368 15 -
382
HNHHF46 48 11263201 - 130415 - AW137103, AW302615, AA913635,
1318
AI765662, T91047, AI525136,
AA393986,
AI056765, T83834, N59019,
AA913173,
N53925, AA700668, 808314,
AI580501,
808368, AI018028, AW081040,
T93861,
T83670, AI307635, AW300106,
AW300120,
AA398023, W04363, and AC008989.
HISAM68 49 11291361 - 521 15 - AI733671, AI439165, AI479274,
535 AI913259,
AI831958, AI017843, AI739264,
AW052131,
AI831355, AA282596, AI793039,
AI793216,
AI261362, and AI792395.
HEQAY32 50 869178 1 - 116915 - AA459604, AA703415, AA703508,
1183 AI337830,
AI924185, AA993540, AA398958,
AA047107,
AI581879, 850486, AA399541,
AA826082,
AA047244, AI570681, AW007699,
AA742413, AI278602, AI479681,
AA810070,
AI346375, AI468327, AA766769,
AI721136,
AA317334, AI378094, H08229,
AA878088,
AI269575, T36249, AA878089,
M78847,
H08868, AW138078, AA322162,
AI824732,
F04540, F04098, AI383526,
F02816, 850380,
AA383971, AI444981, AI953863,
and
AB033004.
HSSJM44 51 871067 1 - 103415 - AA402834, AA313382, T75200,
1048 H10173,
246198, T34442, 813072, AA357096,
AA383450, T07941, AC026352,
AC026352,
AC069443, AC069443, AC068755,
and
AC068755.
HCWDL45 52 11377931 - 117515 - 298747.
1189
HTNBMO1 53 910705 1 - 638 15 - AA298841, and 228624.
652
HAHEF22 54 910996 1 - 872 15 - AA447298.
886
HOSFZ73 55 11284941 - 761 15 - AI879394, AI653605, AI678785,
775 N57282,
AI634691, AW157492, AI703492,
AI270524,
AA086150, AA725075, N67343,
AA100379,
W26914, AA345063, AL046409,
AI284640,
AW2'74349, AI733856, AW020088,
AI754955, AI753488, AI061313,
AW419262,
AL138455, AA610509, AI821714,
AI792133,
AI791913, AW265385, AI753113,
AA579179,
AA410788, AI431303, AI805547,
AL079645,
AA651639, AA127426, AL038936,
AW062724, AI801505, AA226584,
AI783911,
AA747009, AL041690, AW270256,
AI620585, AL046746, AI821785,
AI754023,
AI307201, AA574442, H71429,
AA483223,
353
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW303196, AL134330, AA581903,
AA515728, AW193265, AW301350,
AI801482, AW157456, AW162697,
AI267356, N66026, AA719073,
AW072923,
AA101689, T74524, AI885572,
AI267450,
AL039187, AI925321, AW247819,
AI755202,
AA583394, AW243793, AW406755,
AI066646, AL048925, AI635819,
AW407578,
AA584484, AA719292, AL037910,
AI963720,
AA457249, AI613280, AI805363,
AW304584,
AA130647, H53168, AI687343,
AW167154,
AA665330, AA714011, AL042856,
AW068316, AI278972, AI859280,
AW191886, AA507282, AA521323,
AA879053, AI457597, AC004020,
AC005601,
AC004805, AC004974, AC005387,
AC004019, AL034420, AC005365,
AB017602, AL080317, AL121595,
AL139054,
AL031257, AL022323, 283826,
AC005666,
AC002I26, AC002996, AC006213,
AC004973, AF042091, AC005154,
AC006312, AL121652, AC007298,
U66059,
U50871, D83989, AF015416,
AL034555,
AC005244, AC003983, 298048,
284488,
AC006511, AL121603, AF190465,
AL110502,
AC005971, AC005940, U57009,
AC007919,
U95742, AC005288, AC004659,
AL031674,
X54176, AC005694, AC007051,
U80017,
AL009179, AF015156, AF015151,
U18391,
AC005908, U18394, AF134726,
AC004816,
AC006449, AL031005, X54181,
L78833,
X54180, AC006480, AC005102,
AC010197,
X54175, AC002457, AL031319,
AL022336,
AC007938, AC005015, AL022326,
293017,
AC000052, AP000402, AC005736,
AL021808,
AC004891, 285987, AC006251,
AC006111,
AC006112, AC004999, AL096771,
AC005216, AC005529, U57007,
U47924,
AC009516, AL080241, AC006001,
X55925,
AC002316, AP000553, AF001549,
293016,
AL030996, AL031311, AC003006,
AC004125, AC003982, AC005306,
AC005632, AC007243, AL132992,
U85195,
AC007285, AL031433, AC005699,
AC005486, AC007425, AC004099,
AC005031, AC005808, AL050318,
AC005340, AE000658, AL022143,
AL096701,
AP000088, AC008123, 282190,
AC005229,
X54178, AL121653, U18393,
AC008064,
AF107885, AC006430, 298050,
AC004596,
AC006241, AC005740, AC007216,
AC002377, U29953, U91326,
AC005245,
AC009247, AC004821, AC005071,
U91327,
AP001046, U78027, AC002310,
AL021453,
U08988, AC008372, AP001054,
AC000111,
AC006581, AC005548, AC007364,
AL049830, AL049643, L44140,
AC004953,
AP000513, AL031286, X53550,
AL035587,
AC005768, AL031650, AF109907,
AF015157,
354
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL035422, AC005353, AC006539,
AL049713, AL035410, AC000134,
AC005619, AC002350, AL031053,
AF053356,
AL008718, U57005, AC007536,
AC004496,
AL034418, AC002470, AC005563,
AC008115, AL031280, AC00570I,
L47234,
AC00715I, AP000557, UI8392,
U18387,
AL133245, AC005210, AC003109,
AC004534, AC002385, AL078463,
AC006547, AF165176, AC005393,
AC005746, AL022721, AL078644,
AL096767,
AC005833, AF015149, AL079340,
AC005899,
AL024495, AC005189, 543650,
U02532,
AC005921, AC004996, AL035405,
AF015148,
AC005019, AP000547, AC005323,
AC005726, X54177, AC000026,
AL049829,
AL031848, 282244, AC005874,
AF134471,
AC005682, 284480, AL049766,
AP000152,
AL080250, AP000555, AL021546,
AC007274,
AC004518, AC004032, AC005924,
AL034549, AC005274, AC004626,
AC004858, 281364, U75931,
and AL049795.
HDPTQ41 56 11898141 - 625 15 - AI878836, AI380704, AI949156,
639 AI335537,
AI359669, AI375465, AI279500,
AI658822,
AW001812, AI916799, AI436769,
AA316348,
AI879396, AW014195, AW301192,
AI767924, AI652095, AA028103,
AW299794,
AW236028, AI439173, AW301212,
AA970314, AI824939, F35913,
AA977296,
AW135461, AI927228, AA501553,
D19636,
AI9I5866, AA636041, AA603060,
AA307748,
AI823483, AA625548, AI478932,
AA062899,
AI470601, AI419586, AA028124,
AA488040,
AI760094, AA304578, and L12982.
HDPXN01 57 11285771 - 387 15 - AW 196757, AI093809, AA912880,
401
AA101088, AI651231, AI627422,
W94251,
W94274, AI867562, H06521,
H20526,
AI340603, AW162189, AW403717,
AL045903, AA635382, AI538885,
AL050108,
I89944, AL117649, AL122098,
AL137273,
AL049938, AJ003118, and I80064.
HCEOR02 58 9211101 - 545 15 - AA325666.
559
HCFLI54 59 9213821 - 631 15 - AA835065, AI634477, H04996,
645 AI092992,
812577, 812489, T98498, AI807696,
AI701147, AI336678, 239187,
842405,
838979, 842406, AI376737,
AA243599,
F10155, AA554471, AA758778,
AA417699,
AI445600, AI004105, AA211467,
AA211477,
AI363083, AW150977, AA953676,
F02234,
AA356905, AA193346, AA193464,
AI420621,
AA910341, AI696583, AA836213,
AC005562,
AL035658, 254386, AC023278,
AC023278,
AC023278, AC005562, and AC005562.
HIBEV89 60 11121071 - 108815 - AA352026, D81625, AA457053,
1102 and
AF137367.
HWLUL28 61 9253311 - 738 15 - AA312283, T85523, F06560,
752 AA669475, and
AF044574.
HLMD095 62 928344I - 469 15 - AC020641.
483
355
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HCFCV92 63 11262741 - 911 15 - AI623716, AI458826, AA831121,
925 AI280154,
AI557306, AI500033, AI623717,
AA768629,
and AA687968.
HLHDD45 64 11278821 - 870 15 - AI064968, AW410844, AA621720,
884
AA180857, AW192930, AL138262,
AA757406, AW265468, N78600,
AW 148821,
AI702049, AI002952, AI445699,
AA846014,
AA300049, AA147521, AL121039,
AA311362, AA172103, AA359864,
AA373955, AW139566, AA330694,
W07340,
AI129355, AA668421, AW262572,
AW162314, AW021674, AI251024,
AA425283, AW 157424, AI754257,
AA557945, AI732720, AW419201,
AW162332, AW151541, AI114755,
AA533066, AA489390, AI174703,
AW151848, AI547110, AA601376,
AI355246,
AI744199, AI254267, AA595661,
AW275432,
AI446618, AI572680, AI754926,
AI065031,
AI312267, AA533660, AW023975,
N99245,
AA131594, AW020682, AL039117,
AA610644, AI797998, AI344906,
AI318548,
AA324108, AA640305, AW157128,
AA525753, AA551580, AI732690,
AI349850,
N95424, AI889177, AW069110,
AI076729,
AW023390, AW327673, AI884404,
AW069273, AW162762, AI732327,
AI345166, AI792586, AI792498,
AI039257,
AI174990, AW 151102, AI252611,
AI003469,
AI590442, AL039436, AI791659,
AI744890,
AA631915, AI754064, AA502450,
AI567676,
AA315052, AA593168, AI270280,
AI310670,
AA935827, AI744963, AI570067,
AI312614,
AI114494, AI921744, AA524604,
AA828840,
AA664963, AI813920, AA748071,
AI890283,
AW069227, AI955447, AA133568,
AA523718, AA015948, AI538404,
AI609992,
AI221027, AW277125, AA350081,
AA569220, N72678, H53546,
AA669238,
AA313025, AI360521, AL135420,
AW020198, AL135513, AA601712,
AI028148, AA535558, AI613459,
AI755227,
N72509, AA503144, AI431442,
AW243817,
AI174827, AA507623, AW029626,
AI734119,
AI889345, AI753131, AA084439,
AW268793,
AA657392, AA658890, AI819419,
AW337483, AA702637, AL039471,
861887,
AA807704, H47461, AW028376,
AI434103,
AI345256, AI745666, AI571894,
AW 177224,
AC005821, AC008372, 283840,
AC006261,
AC005701, AF196779, AC005696,
AC005519, AF111168, AC005409,
AC005759, AL031670, AC002565,
AC007684, AC010205, AF109907,
AP000557,
AJ003147, AL121655, AC006511,
298200,
AC007308, AL133448, AC006509,
AB016897, AP000512, L44140,
AL109798,
U91327, AD000092, AC006057,
AC005900,
AL121595, AL133163, AL035659,
AC006241,
356
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL109952, AC002039, AL121603,
AL096701,
AP000505, AC005527, AL096712,
AL049538,
AC004263, AL021808, AC002477,
AL050307, 299714, AF001549,
AC000075,
AL121653, 284469, AC004125,
AC005037,
AC007050, AL031289, AC005618,
AC005412, AC006398, AC007536,
L47334,
AL031255, AC005261, AC004019,
AB023051, AC004041, AP000309,
AC002991, AC009516, 298742,
AC005822,
AC007057, 298752, AC007676,
AC005484,
Y14768, AP000030, 283844,
AC004771,
AJ011930, AF134726, AL096791,
AC003109,
AC006487, AP000553, AC005722,
AL031846,
AP000048, AC005071, AC004084,
AC006255, AC004859, AP000250,
AC005180, AC005808, AL031681,
U52112,
AC008044, AC005244, AP000211,
AP000133,
AL021453, AF196971, AC005003,
292542,
AC005768, AL031680, AC002310,
AC006011, AC005212, AL031281,
AP000359,
AP001046, AL078477, AC005303,
AC005921,
AC004765, AP000503, AC007510,
M63796,
AC002126, AL109653, AC002375,
AC006064, U93163, AL049869,
AF165926,
AC005632, 284474, AL022165,
AP000116,
AL035684, AC004890, AL022323,
AC005944, AP000555, 298051,
AC008929,
AC005225, AC005228, AF207550,
AC005562, AC002306, AC006146,
AL022326, AC005041, AC006050,
AL031666, AF129756, U96629,
AC005377,
AC006539, 273979, AC006547,
AL050338,
AC004812, AC004584, AL021394,
AC007736, U50871, AL022336,
AC000379,
AL022315, AC011456, AC002036,
AC006088, AC009946, AC005920,
AC007036, AC007371, AL022316,
AC005839, AC004686, AL021579,
AP000504,
AF213461, AC005346, AC005175,
AB011399, 293017, AL035460,
AC005274,
297630, AC004000, AC005365,
AC006388,
AL080243, AC005529, AC006318,
AP000556,
AL049694, AL021391, AC005500,
U80017,
AC002472, AC004814, AL031228,
AC005015, AC002312, AB023048,
AC004531, AL022476, AP000511,
AL020997,
215025, AC007051, AC004895,
AC005775,
AL034420, AL049839, AC006942,
AC012627, AC016026, AC007537,
AC004106, AC005295, AC007314,
AL122020, AC004685, AC004967,
U95742,
AB003151, AL031003, AC006455,
293244,
AL139054, AL050341, AC004476,
AF001550,
AL137654, AF205588, AC000353,
AC005730,
299716, AL031311, AC002351,
AC007421,
AC007216, AB004907, AF038458,
AF053356,
AC005253, AC004491, AC003688,
AC003982, AC005664, Y07848,
AL121825,
357
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
and AC003665.
HHSGV13 65 10385571 - 1254 15 - AW157772, AI768325, AW072067,
1268
AW163204, D52151, D52158,
C14535,
D52025, AW090592, D52014,
AA916782,
C14534, AI589300, AI268693,
D51740,
D51951, 854483, D59739, H19000,
AI341953,
AA627910, C14295, T15574,
H49512,
AA907297, H41615, D59792,
245247,
H40838, D52130, 241478, H19101,
F08485,
D51823, F04956, D51574, D59715,
AA363868, T31138, 852319,
H49742,
H06704, F04609, C14365, T33909,
T34829,
AA333764, AI681322, and AL050342.
HDPSJ02 66 9433161 - 1272 15 - AA366176, AL109804, AL109804,
1286 and
AL109804.
HBGQN46 67 9453701 - 888 15 - AA479990, AW293680, AI473367,
902 AI184880,
AI086741, AI081183, AI214276,
AA742259,
AA836754, 855060, AA251267,
AI285889,
AI813391, AW297831, AI819671,
AF038458,
and AF038458.
HE2SN25 68 11274611 - 1170 15 - AW327262, AW327616, AI769182,
1184
AA725234, M85521, AI016714,
AI051725,
N62194, AA483400, AA483411,
AA847865,
AI554330, AA902896, 860056,
N66755,
AA594900, AA933624, AI825794,
H05474,
T16298, AA977118, AI671131,
AA054722,
AA650410, 843427, AA916000,
T34734,
AA716570, AA761969, T90105,
AA054669,
AA342241, AA805766, AA811545,
and
T82929.
HRODF07 69 9524261 - 324 15 - AC411597, and AC023402.
338
HE8BQ58 70 11940601 - 708 15 - AW360898, AW360924, W67828,
722 AA522448,
W67835, N32016, AW360960,
AI803415,
AI679943, AA808169, AI131493,
AA677192,
AI299775, AI694771, W67971,
AI075655,
AI719966, AW439363, N32871,
AI264272,
AI679433, AI037908, AW276181,
AA454003,
N31580, W65305, AI077995,
AI032435,
AI610717, 891886, W65335,
AI022492,
AA598921, H50213, AA682589,
892723,
N41821, H98160, W67755, AA774316,
AA363908, AI370035, AI659568,
AI872516,
AI932585, AI886059, AA909496,
W80827,
AI702322, AI469319, AA894457,
AA948065,
AA384221, W80948, AA911990,
AA679575,
C14559, ALI37600, and AL096766.
HNHCI32 71 8616731 - 586 15 - AF112462, and AR035954.
600
HSQCM85 72 11246891 - 614 15 - AL021918.
628
.
HPTVL90 73 5094871 - 322 15 - AI694439, AI742084, AI808204,
336 AI458889,
AI005161, AI472051, AI126407,
AA994212,
AI564776, AI379936, AA044826,
AW418896,
AA335622, AI308950, AI948596,
AA996109,
AI798664, AI689840, AI802140,
AI570505,
AI268684, AI738645, AI708063,
AW166260,
AI742586, AI819324, AI018575,
AA983545,
AI051014, AI823636, AI498702,
AI948603,
and AF126781.
HRDFA94 74 11563471 - 2768 15 -
2782
358
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HCE1S21 75 10107971 - 495 15 - AA663839, T64371, AC007666,
509 AC000052,
and AC004019.
HWHHWS 76 6841251 - 1134I5 - AI537869, N58734, 897517,
1148 N65985, H59433,
4 AA022869, H70636, 897516,
AA011230,
AA443442, AA057027, W05627,
AW192697,
AA808430, AA780044, AI022809,
AI041819,
AI986294, AI336274, W39201,
AA883903,
AI073467, AI740785, AI871953,
AI521233,
AW009412, AW157214, AA554447,
AI742678, AA863294, AA937977,
AI589839,
AA595998, AA689601, AA932317,
AW152255, AA886725, AI669406,
AI034240,
AI925407, AA036917, AI887353,
H47150,
AA846564, AI127132, AA978039,
AI139401,
AA806498, AA443308, AI338458,
AI042442,
AA890338, AA992867, AA463838,
AI085301,
AI263340, AA026818, AI277999,
AA917926,
AA854105, AI080542, AI348041,
W07723,
and AA460271.
HDPGQ74 77 12234381 - 394315 - N31712, AL118600, NS8487,
3957 AI741189,
AI816927, AI797840, AW 149500,
AI819260,
AI693960, AI827378, AW409925,
AI581296,
AI934753, AW295876, AI094419,
AW026705, AI031621, AA447165,
AI434580,
AI298291, AA443793, AI924337,
AI890661,
AI590648, AW081058, AI061351,
AA617780,
W60708, AI689288, AI310105,
AW072975,
AI761653, AI393142, AI032061,
AI678346,
AW296260, AI913605, AI339277,
AA524221,
AI623926, AI472781, W60770,
AI024132,
N70795, AA196520, AI453676,
AW292215,
AI583157, AI016034, AA513345,
AA813380,
T08803, D31273, AW085565,
AA639605,
D31339, AL135572, N78076,
AW075684,
858936, AI282095, AW028510,
AA746071,
802150, 861455, AW104232,
800910,
T09383, AA661620, RI4752,
T98158,
831323, AA470871, AI817106,
AI091558,
AW239033, T98157, W01411,
AI873752,
842522, AL041302, 808452,
846428,
D12114, 808451, AW026023,
N42367,
AI263720, AA995486, AI472597,
AA861918,
T08I32, AI824234, 831582,
AI432969,
AI274541, AI445025, AL121328,
AI539780,
AW104724, AI560099, AI538716,
AW 118512, AI564719, AI802542,
AW026882, AI433157, AI687375,
AI580984,
AW150578, AI886753, AI6I9502,
AI818683,
AI637584, AI569616, AI783504,
AI682841,
AI625079, AL036361, AI620284,
AW087445,
AW192375, AI697137, AI687127,
AI440239,
AI799470, AI635461, AW071417,
AI469532,
AI445432, AL121270, AW071349,
AL045500,
AI610307, AL047763, AI954183,
AI687728,
AL036274, AI815855, AI160954,
AW151485,
AI696398, AL044207, AI889376,
AL079963,
AI580190, AI816947, AW148408,
AI349004,
~AW086113, AI281762, AI702406,
AI612913,
AI499393, AL036396, AI800433,
AI349772,
359
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL038605, AW238730, AI696612,
AI224992,
AI271786, AI281773, AL036802,
AW274192,
AI800453, AI521012, AI872711,
AI921379,
AW16207I, AI682971, AI812080,
AI627360,
AI590128, AI269205, AI702068,
AI624206,
AI250293, AI524671, AW008048,
AW132056, AL040243, AI274508,
AL036146,
AI890833, AI636456, AI926790,
AIS39771,
AI690480, AW103371, AI800384,
AI921248,
AW087462, AW129106, AI440426,
AI702073, AL121365, AW301409,
AW166970, AI536638, AA572758,
AW 118557, AI690426, AI475371,
AI249323,
AI758437, AI285735, AI538259,
AI701074,
AA853351, AI683684, AI499463,
AI249257,
AL043326, AI340582, AL135661,
AI275175,
AI281779, AI570384, AI857296,
AI702433,
AW 149869, AI282281, AI673297,
AW075351, AI537303, AI631107,
AI269696,
AW148320, AI868831, AW183130,
AI500077, AI349645, AI633419,
AI498579,
AI866002, AI887396, AI433976,
AW169653,
AI567993, AI610645, AW074993,
AI567351,
AI536685, AI349614, AA640779,
AL040169,
AA613907, AI554245, I89947,
I48979,
AL049452, I48978, AF113694,
I89931,
AL117460, AL050393, AF090934,
AL050149,
AF090901, AL110196, AJ000937,
AF090900,
AF090903, AL117457, AL133016,
AF104032,
568736, A08916, AF113677,
S78214,
AL133075, L31397, AL133606,
Yl I587,
AL050116, AL133560, A08913,
AL122050,
AF113013, AF113699, L31396,
AF113689,
AF118070, AL049314, AF113690,
AF106862,
AL080060, AF090896, AL122121,
Y16645,
AL050146, AL050108, AF177401,
AL137527,
AL049938, AR059958, AF078844,
AL122093,
AF113691, AB019565, AL110221,
AF090943,
AF118064, X84990, AJ242859,
AF125949,
AF113676, AL133640, A93016,
AL137459,
AL050277, AL133557, AL096744,
AF113019,
AL133080, AL117583, AL117394,
X82434,
Y11254, AL133565, AL049466,
AF146568,
AF091084, I49625, AL080124,
AF017152,
AF079765, AL110225, U42766,
AF111851,
AF125948, AL133093, AF158248,
AL080137,
X63574, E07361, AL117585,
AL122123,
U91329, AL137550, X70685,
E03348,
AR011880, AJ238278, AL137557,
U00763,
AL050138, AL049430, AF017437,
A08910,
AF097996, AL049464, AL133I
13, U35846,
E07108, AL137283, A65341,
E02349,
X65873, AL049382, AL049300,
AL117435,
AL137648, U72620, AL122098,
AL050024,
A08912, A12297, AF118094,
AL122110,
A08909, AL137538, A03736,
I03321,
AF183393, AL137271, 282022,
A58524,
A58523, A77033, A77035, AL137463,
AL049283, I33392, U80742,
AF067728,
360
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL133568, X72889, AF087943,
AL110197,
I09360, AL080127, X96540,
X93495,
AL133072, AF079763, X98834,
AF111112,
272491, U67958, I26207, AL137521,
AL080159, A07647, Y09972,
I42402, 561953,
AL137523, AF061943, E15569,
AF026124,
E08263, E08264, AL137526,
AL050172,
AL122049, AR038969, AL133077,
AL133014,
AJ012755, AC004227, AL133104,
E05822,
I17767, AF000145, AR013797,
A93350,
AF119337, AL137560, 237987,
AR000496,
U39656, I00734, AL122111,
E00617, E00717,
E00778, E08631, AL023657,
I66342, U68387,
AF026816, AL137556, AF132676,
AF061836,
A08911, Y14314, AF100931,
AL110280,
AC006336, AF003737, AL133098,
AF106827,
M30514, AF057300, AF111849,
AF057299,
AL117440, AL080074, AL133081,
Y07905,
AL133067, AF162270, U49908,
AF153205,
X92070, U96683, A45787, AF185576,
. AL137429, U58996, AL122118,
E02221,
AF081197, X62580, AR038854,
E06743,
AL137705, AB007812, AJ006417,
X83508,
D83032, U78525, AF008439,
X87582,
AC004200, L30117, AF061795,
AF151685,
AC004690, AF126247, A90832,
AC007390,
E04233, AL137533, and AR054984.
HTXGF27 78 6957661 - 128315 - AI935291, AI565606, AW055263,
1297 AA827998,
AA134925, 871442, W73084,
W37623,
AI376157, AW071733, AA760869,
AW084636, AW084135, N40260,
W37624,
AA621956, AI261507, AI024926,
AA576858,
AA782442, AI753564, W73188,
AA457140,
AI362706, AI088401, W37568,
N80584,
AA100989, AI870558, AA552108,
AA464487,
AA577315, H99262, N42314,
AA135041,
AA099421, AA9I7378, AI955891,
AW009052, AI865605, AI811602,
W37443,
AA506577, N28234, AI564918,
W00732,
H56180, AI784357, W07706,
AW407317,
AI571677, T64405, AI018764,
AA297089,
871095, AA297614, F19530,
AA628651,
H56396, AA588512, T64219,
AI291707,
839750, AA622681, 836668,
AI564962,
AA814874, AI868306, AW247018,
AA082510, C00495, AL117567,
and
AF151851.
HAPQW27 79 12171911 - 979 IS - AA639858, AI951569, AI354569,
993 AW264601,
AW054709, AI090445, AA430536,
AA629365, AA700759, AW264109,
AW391923, 899213, AI367529,
899214,
AA621416, AA994116, AI366194,
AA535876,
AI659168, AA857919, T79408,
AI338674,
AA453512, AI183858, N76754,
AA97814I,
H27149, AI219725, AW015835,
H45923,
848474, AI868900, H45924,
AA493368,
AI472888, AA478001, T79494,
239933,
F31223, H24791, AA453511,
F35256,
848475, 807932, M79086, AW009601,
361
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
T35085, AI969822, AA478000,
AA635101,
AA430495, AA769695, AA772948,
AA962346, AF059202, AF078752,
and
AW613082.
HCUGR38 80 7064711 - 332 15 -
346
HCUGN19 81 7169891 - 584 15 - 883518, H01355, 883503, AA204689,
598
AI990886, AI660160, H45024,
AI300806,
AI969915, AI927423, AI457940,
AI744631,
AI928256, AI380503, AI867197,
AW237763,
AI800708, AI588959, AI765531,
AW300271,
AI830241, AI762594, AA828477,
AW058189,
AI871379, AI740633, AW301155,
AA937166,
AW316942, H44971, AA804639,
AA535256,
AW071230, 831122, 865687,
H01309,
H28671, AI829069, AA767789,
AA953355,
AW138552, AI870155, AI092045,
and
AA207090.
HDPTW90 82 11711611 - 628 15 -
642
HPTGB43 83 7264601 - 492 15 - AA573537, AI160878, AA885566,
506 AA861893,
AA433946, AA568688, AA811995,
AA442766, AA838602, AW168298,
AI283278, AI015935, AA782093,
AI472891,
AI199547, AA573777, AI085835,
AI669114,
AI690776, T61807, AA652483,
AA086353,
AW204782, AI004311, AI566973,
AA501347,
AI281530, AA876623, AI589871,
AW138834,
AW245578, AA613669, AA714315,
AA813327, AA507560, N52392,
AA492250,
AI221056, AA446582, AI083879,
AI304532,
AI304454, AA531050, AA720002,
AI304455,
AA720021, N54353, AA418354,
AI937637,
AI573258, AI382182, AI557530,
AI244679,
AI557529, AA305352, N30214,
H85048,
AA918480, AA230200, AI571328,
AI859175,
AI264256, F21642, H65466,
AI991112,
H91692, C00330, T73417, N63050,
H93999,
AW300104, AI885837, AA134203,
T71348,
AI808444, N32117, AI985397,
AA855127,
AA431169, T55136, AA291581,
230219,
T73332, H72870, H77954, N63300,
AI141454,
AA293323, AA432189, AW150864,
T61353,
T73347, AA229346, T72864,
N88648,
AI251780, AA641099, AA625514,
850529,
AW245568, H78357, T98646,
F15963,
AA430753, H72469, AA313563,
H85040,
AA446709, AA938645, AA522761,
AF113123, and AR009500.
HEON059 84 7413611 - 848 15 - W37916, AW369323, AL138197,
862 AA292636,
AA789205, AA278688, AI077497,
AI670821,
AW117287, AA608906, AA382777,
AA724269, AA278680, AA827227,
AI160796,
AA600253, AI990171, AA625768,
W37874,
AA421286, AA292637, AA844108,
AA917528, AW316905, AA768446,
and
AF117210.
HWBBR65 85 116.52641 - 2227 15 - AI110760, AL040921, AL048969,
2241 AL044339,
AL044340, AI608771, AL037632,
AW 102811,
AI054414, AW157180, AW188427,
AI952885, AI302688, AL048626,
AW080062,
362
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL044489, AL042905, AL042906,
AA223932, AA126635, AI791227,
AL119331,
AI076616, AW408643, AL138265,
AW243793, AI354847, AI679294,
AL135377,
AA134961, AI679871, AA601278,
AI694178,
AI732911, AW069819, AA487475,
AI907046,
AI457389, H57596, AI961264,
AA736713,
AL041013, AI871691, AI816537,
AA287618,
AA020873, AL138065, AL137984,
AI917156,
ALI20343, AA456937, AL079869,
AW405593, AW008089, U51704,
AL120483,
AI141202, AA084401, AW401509,
AA634991, AA081138, AI457152,
AA580560,
AW372037, AI445582, N76766,
AA601503,
H77505, AA017377, AA831913,
AL041895,
AA527963, AA618412, AL038705,
AI016192,
N23097, AA608588, AI583978,
AA706495,
AA284247, W96277, AA575852,
AA601230,
AA584482, AL134338, AI580906,
AA586907,
AA608612, AA838140, AI581006,
AA640277,
AI798521, AA297145, AL120269,
AW169057, AA984258, AI143051,
AA568303, AI801141, AA834799,
AI820992,
AI734144, AI732128, AI732635,
AA568314,
AA224525, AI913324, AA489856,
AI433104,
N23913, AL118925, AI016704,
AI612111,
AA613164, AA908687, AL043095,
AL046746, AL134216, AA130647,
AA908857, H57595, AI823679,
F28204,
N27362, AI982808, AA862035,
AC005409,
AC010205, AC005529, AC003101,
AL109952, AF207550, AC005519,
AC005071,
AC007226, AF109907, AC005225,
AL109627,
284469, AL139054, AC004167,
AC005632,
U80017, AC006449, AC005488,
AC004030,
AC005527, AC006241, 298044,
AC009247,
AC006441, AC004999, AL022311,
297876,
AC006538, AL035420, AC020663,
AC005944, AC006312, AF217403,
AC004542, AL022316, AL035086,
AC007686, AL031602, AL008718,
AL109827,
AC004491, AC005821, AF001550,
AP000694,
AC000025, AC002425, AC005512,
AC003665, AL020997, 283844,
AC008044,
AC012085, AC004821, AC004913,
U78027,
AC006064, AL121603, AD000092,
AC005280, AC004973, AC005288,
AC005778, AL109984, AC005808,
AF111168,
AC005696, AC000353, AC005619,
AL080317, AC004929, AP000030,
AC005231,
AF196779, AL035587, AC006251,
AL031284,
AL031295, AC005666, AL133246,
AC006211, AP000558, AL023575,
AL049795,
AC005412, AL023553, AC005911,
L78810,
AC005037, AL022315, AC006946,
AL009181, U47924, AC006084,
AL021391,
AF134726, AP000557, 283822,
AC006057,
AC005057, AC004150, AC004447,
AL035422, AC004854, AC004033,
363
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC004893, AF196969, AL133448,
AL136295,
AC004230, AC005828, 282976,
AL022238,
AC005005, AL031657, AC004859,
AC003982, AC004985, AP000555,
AC007546, AP000116, AC007283,
AP000350,
AC004448, AC004991, AC005261,
AC005015, AL035462, AC006255,
AC004526, AC004671, U96629,
AL050307,
AL031587, AP000211, AP000133,
L44140,
AC003688, AL031666, AC005763,
AC005624, 298051, AC005088,
AC005041,
297183, AL022237, AL049780,
AP000065,
AC004686, AL021579, AC002477,
AL109963, AL132712, AP000501,
AC005500,
AC016830, AL035458, AL122020,
284480,
297054, AL096774, AC005803,
283840,
AC003043, AL031848, AF196971,
AC004783,
AL031681, AC004383, AC005049,
AC005274, AL031281, AL050321,
AL080243,
AC004966; AC005391, AC005484,
AC002310, AC005914, AC007021,
285986,
AL022322, M63796, AC006597,
AC006120,
AC002395, U62293, AC007666,
AC004675,
295114, AC002300, AC004887,
AP000503,
AF088219, AL035423, AL031680,
AC005730,
AC006450, AC005800, AC005618,
293023,
AL121653, AF045555, AL020993,
295152,
U95739, AL031432, AF030453,
AC006071,
AC004139, AC005081, AC005971,
AL008725, AL034379, AC004797,
AL022476,
AL049643, AC007421, AC002558,
AC006285, AC007565, AL034420,
AC004531, AC005399, AL024507,
AC004234, AC002312, AB015355,
AC004881, AC006468, AC005921,
AC002470, AL031591, AC006487,
AC002365, AC005670, D87675,
293244,
AC007384, AC005736, AC005913,
299716,
AC006121, AL133163, AC006146,
AC005940, AC004975, AC004148,
AC005620, and AC006480.
HFTCF28 86 7786531 - 530 15 - W96302.
544
HEGA083 87 7808371 - 314 15 - AR064011, AC024009, AC040991,
328 and
AC040991.
HPIAU71 88 11251711 - 729 15 -
743
HYABB43 89 11263561 - 1224 15 - AI052516, AI887969, AI459300,
1238 AI279457,
AW008970, AA582206, AA131782,
N20025,
AA621643, and AC010175.
HHPDX35 90 11822771 - 2653 15 - AI809872, AW019999, AW104416,
2667
AA442453, AI591161, AI627704,
AI480372,
AI174542, AW379311, AA579804,
AA622859, AW376415, H73145,
D79894,
D61710, D79938, AW263340,
C16335,
D63058, AA329542, 899362,
H12512,
AW268159, N94060, 848020,
D62767,
N69569, AW069883, AI683005,
AW151861,
AW151968, AW379305, F24300,
and
AI431678.
HHAMF38 91 ~ 11931981 - 2197 15 - AW002967 AW027779, AI803049,
~ 2211
364
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW194946, AW182921, AI983694,
AA978351, AI658726, AI219858,
AI669330,
AW418951, AI984802, AA128041,
AI942355,
AI038656, AI697774, AI694647,
T74734,
AI830735, AI922255, AI658577,
AW129197,
M77987, AI918192, T48344,
AA128086,
T50347, AA970231, AA702280,
AI191395,
AA912726, AI570573, AW450850,
AI364931,
AI459038, AI224891, D45721,
AA836277,
AI433889, AF211943, AF187014,
U13395,
AF187015, AC009044, and AF212843.
HFIJC31 92 8281481 - 519 15 - AA885328, N79858, and AI184184.
533
HNTRL43 93 1143390I - 1595 15 - AI620476, AII98431, AI937934,
1609 AW156979,
AA206763, AI457180, AI310199,
AI310203,
AW162701, AI571493, AI653833,
AI803863,
AI659993, AI202174, AA081483,
AI625328,
AW161809, AA084738, T33252,
AI474375,
AW449706, AA476436, AA595562,
AI879117, 845502, AI632327,
838512,
H39115, 241406, AI420351,
AA206949,
245755, T05387, D52927, AW162666,
AA476541, AW054938; AI783994,
and
AA928185.
HOFNC80 94 11932201 - 1880 15 - AA837819, and AF111714.
1894
HBJJX53 95 12170301 - 578 15 - AA477047, AW383764, AA321993,
592
AA309810, W25768, AA465618,
850327,
824995, AA368102, W07130,
AL036509,
AW015964, AA356448, AW021281,
AA188385, AI417948, AW020382,
N58603,
AA146868, AW327881, AW022474,
AL037408, AI253617, AW020385,
AW024028, AW022377, AW250576,
AW078617, AW014150, AA935403,
AA568927, AA527489, AI061593,
AI889745,
N75635, AW328274, D30900,
AA368997,
AA644214, AI611444, AA938035,
AA642852,
AI971358, AA541570, AW440667,
AA847331, AI581824, AA885549,
AW023048, AA501970, AI371411,
AW022117, AW019893, AI220689,
AA528461, AI189988, AI748837,
F15644,
N21994, AA659814, N27409,
N73091,
AI369148, T52918, H90255,
AW068298,
AI271812, AI143404, F30162,
AI621356,
AI682399, T94204, AI468324,
AA113423,
AI309282, AA187792, AA157054,
AI879792,
N64072, AA558529, AA630443,
AA317564,
T46922, T46909, AA634008,
AA352649,
H77792, AA173921, AA316284,
AA316553,
AA316955, N77939, AA307553,
N73723,
AI701305, 853898, D51124,
AA648585,
AA533759, AA773206, F01306,
T59924,
AI191170, F26077, AA649685,
AA731036,
F32367, H27523, N22397, AA115852,
T27636, AI751041, T59028,
853908, H02747,
F24376, AW327840, AA301510,
AA468983,
H88026, F26670, N68119, H96065,
AI090441,
F34227, F31831, AI791923,
T53038,
AA525463, AA526678, AI792408,
365
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW058162, N75815, F22445,
D12081,
W69552, T56001, D11595, F21762,
D11746,
H88248, F20819, F20636, AC005071,
AF161080, AF161081, AC005406,
and
D14530.
HNTBF75 96 10903391 - 650 15 - AI659901, AF078850, U81186,
664 and
AC002069.
HSKIA89 97 8379861 - 909 15 - AW204099, AA314747, AA249613,
923
AW301249, AI261562, AA775742,
AA609749, AI446434, and J02649.
HHAME78 98 8409391 - 413 15 - AA430753, AW245568, AA625514,
427 H72469,
AA446709, AI885837, H95032,
AI991112,
AI382182, AA313563, W00555,
886214,
850625, W00611, AI589871,
N78252,
AA305352, H64869, AI573258,
N30214,
H78356, T60510, AA507560,
AA613669,
N56787, AA429728, AW168298,
AI015935,
H91789, N63300, H73548, H84670,
AW245578, AI244679, N63050,
N88648,
T72288, AI669114, N52392,
220777, 230219,
AA714315, AA433946, AA442766,
AI808444,
AA641099, AA568688, AI557529,
AA813327,
AI557530, AA492250, T72293,
AI083879,
AI221056, AI937637, AW440575,
AA720021,
AA446582, AA782093, AA134202,
AI304532,
T71510, AA418354, N40867,
AI281530,
AI304455, AA855127, N72798,
T73399,
AA573777, T73332, AA811995,
T98698,
AA838602, AI085835, H47484,
AA652483,
AI304454, AA720002, AA885566,
AA531050,
AA573537, AA918480, AA861893,
AI199547,
AI160878, AA876623, AI283278,
AI690776,
AI566973, AI472891, AA230291,
H65466,
T61353, H84633, N54353, T61807,
F21642,
AI571328, N76319, H91692,
T71348,
AF113123, AR009500, and A74991.
HHFCI36 99 8442851 - 337 15 - AA297665, AA298879, AL049946,
351
AC004616, AC073582, AC073582,
AC011307, AC011307, AC004616,
AC011302, AC011302, and AC011302.
HDPXL24 100 11822661 - 311515 - AA486735, AA421808, N53555,
3129 AI922158,
AW052105, AI032935, AI031641,
AA429482,
AA478009, AI375186, AI804201,
AI361364,
AI864580, AA937131, AI347674,
AI936668,
AI818995, AA977133, AI192230,
H22126,
AA009894, AA402775, AI695593,
AI695105,
H12820, AA402210, AA366176,
AW 170283,
AA486734, 848413, H39702,
AI371102,
AA009785, AI301705, AA443494,
AA478164,
N72513, and AI906819.
HACCH94 101 8471431 - 139915 - AI093369, AW292321, AA972431,
1413 N40174,
AA746376, AA130392, AA286750,
AA287684, 871586, 871568,
871587,
H03136, H03946, 871567, AI471079,
H97311,
AA365025, AF039686, AF118670,
AR034800,
AF081916, AL161458, and AL161458.
HTEOF80 102 11812041 - 170615 - 899817, AF186084, and AL117610.
1720
L HTEED80103 8490751 - 129915 - W87655, AA465429, AA203572,
~ 1313 AI479983,
366
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI540082, AA192438, AA836236,
AA465358,
AA829419, AA507269, AW290970,
AI796504, AA904433, AA368409,
AA688079,
AW 189971, AA601527, AA393948,
F36549,
W87656, AA320120, AI862710,
F30605,
AA196706, and AJ242978.
HDPND85 104 8526281 - 841 15 - W58472, W58514, T49180, AI356759,
855
AW351512, AC003042, AC003042,
and
AC003042.
HKABI68 105 8565901 - 548 15 - AW249217, AA534535, AA115832,
562
AA315785, AA429231, T08490,
AW404684,
242191, AA336855, AC007606,
and
AC007606.
HWHP029 106 8573831 - 657 15 - AL049779, and AL049779.
671
H7TBC95 107 8659221 - 692 15 -
706
HBGDA14 108 8662581 - 879 15 - AC024580, and AC074220.
893
HSLHT48 109 12079451 - 165215 - AI526125.
1666
HE2KL28 110 11274591 - 864 15 - AI274972, AI015495, F34649,
878 AA746678,
C04411, and 230107.
HCFND04 111 11563111 - 179415 - AI091533, AI276640, AI802181,
1808 AA385823,
AI613038, AI802542, AI924686,
AL040243,
AW071417, AL042628, AW103628,
AI537677, AA225339, AW088899,
AI932794,
AI567582, AI570807, AI270183,
F27788,
AI288285, AW149925, AI824576,
AI923989,
AI499285, AI680498, AI917252,
AL121286,
AW150457, AI221035, AI345416,
AI345612,
AI932638, AI678357, AI345415,
AW160916,
AW268122, AI440239, AI610362,
AI866770,
AI890223, AI929108, AI637748,
AW 129230,
AI431909, AI952862, AI491852,
AI358701,
AI274745, AI564259, AI812015,
AW079572,
AW020561, AL046942, AI963846,
AI934011,
AL042745, AI335426, AI348777,
AL041150,
AW263823, AI636588, AI648502,
AL045266,
AI874166, AI280732, AI811912,
AI184903,
AI627988, AA833760, AI612913,
AI956080,
AI554821, AW168485, AW073697,
AI623682, AW268302, AL048871,
AI620089,
AW072719, AI500588, AL038445,
AI802240,
AI500061, AI670009, AI284484,
AI207572,
AW087938, AI633125, AI334445,
AL039086,
AI254731, AI475371, AI473799,
AI624084,
AI890907, AW 151847, AL079963,
AI798456,
AI468872, AW084219, AL039276,
AL048323,
AI698391, AL037582, AL037602,
AI591407,
AL048340, AI950892, AA427700,
AI673363,
AI554344, AI560184, AL036548,
AI916419,
AI344928, AI758437, AL043326,
AI537617,
AI862135, AL036638, AL110306,
AW083573,
AW083750, AI281867, AL119399,
AW020164, AI280661, AL036541,
AW262565, AI826225, C16221,
AI811785,
AL079740, AI927755, 299428,
AW151136,
AW105431, AI865906, AW029611,
AA806720, AW079409, AI491775,
AI689420,
AI571439, AI612759, AI969655,
AI241923,
AW 162189, AW089310, AW079075,
367
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI497733, AI473536, AI559296,
AW170635,
AI921176, AI635016, AW150762,
AW089258, AI611738, AI619502,
AI569616,
AI677796, AI306613, AI889133,
AI352497,
AI433976, AI873604, AI922901,
AI349967,
AI608676, AW301513, AL045997,
AW198090, AI365256, AW026882,
AI537261, AI539771, AI567351,
AW163834,
AI608936, AI633419, AW167918,
AI648509,
AI433157, AI702073, AI269862,
AI758512,
AW150225, AI921746, AW268220,
AA640779, AA287231, AL119863,
AI250663,
AI334450, AI340603, AI866162,
AI638798,
AW079336, AI679990, AI249877,
AI686817,
AI270706, AI699865, AA572758,
AI860694,
AI285586, AI251221, AI270429,
AW129106,
AW073677, AI915291, AI587606,
AW 152182, AI879064, AI345477,
AI955866,
AI520809, AI590118, AI829327,
AI687295,
AI539847, AW118518, AI538829,
AW059713, AI580436, AI310575,
AI610645,
AW193236, AW161156, 881679,
AI950664,
AI889953, AW 162194, AW 105601,
AI340S33, AI571909, AI627880,
AI922315,
AI270055, AI824746, AI682743,
AI923370,
AW 163464, AI275640, AW 151729,
AI624693, AI886124, AW051258,
AW169604, AC007068, AL122098,
AF026816, AF158248, AF118094,
AF113690,
I89947, AF118070, A77033,
A77035,
ALI17460, AL133075, AL122110,
I33392,
AL137550, 272491, I48978,
282022,
AL117585, AL117457, A03736,
AL110221,
Y16645, AL049283, Y11254,
AR011880,
A08913, AL050116, A08916,
AL133080,
AF113677, AR059958, AL117435,
A65341,
AL050172, S68736, AL133014,
AF057300,
AF057299, AL110196, A08910,
I89931,
A08909, AL049382, AL137271,
AL050277,
AF090903, AL133016, I49625,
AF067728,
AL050024, AF111851, L31396,
AL096744,
L31397, I48979, AL122050,
E02349,
AF078844, AF091084, X82434,
U80742,
AF106862, AF113694, AL137557,
AF125948,
X72889, Y11587, AL137533,
AL137463,
AR038969, AL133104, AJ242859,
AF017152,
AF090900, AF061943, AL133067,
AF017437,
AL049452, AL049314, AF185576,
AL122093,
I26207, AJ012755, AF104032,
AB019565,
AJ000937, AL137459, AL050108,
A08912,
561953, AL110280, AF090934,
AL080159,
AL~137560, AF090901, X98834,
AL049466,
E03348, AF113689, I66342,
AF177401,
E04233, AF087943, 578214,
X84990, I00734,
AR000496, U39656, X70685,
AL137538,
AF1I3013, E00617, E00717,
E00778,
AL050393, X93495, U72620,
AL122121,
U49908, AR038854, AF113699,
I42402,
U00763, AF153205, U96683,
U78525,
368
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL133560, AL080124, U42766,
AL137521,
AL137476, AL122123, AF003737,
AF097996,
AF183393, AJ238278, AL133113,
AL050138,
X96540, AF081197, A58524,
A58523,
U67958, U35846, AFI l I 112,
AL133557,
AF090896, AF113019, AF090943,
AF079763,
AL049464, A93350, AF026124,
Y14314,
AL050149, E02221, AF061573,
AL080074,
AL049430, AL137648, AF113691,
A07647,
AL050146, AF146568, AL137556,
I03321,
AL133640, M30514, E07108,
AF125949,
AF113676, AL110225, AL117394,
A12297,
AL133565, AL133606, X63574,
U91329,
AL080060, U58996, AL137526,
AL117583,
AL110197, E15569, AF162270,
AL137527,
AL133072, X65873, AF079765,
AF119337,
A90832, AL049938, AL080127,
AL117440,
Y09972, AL133568, E12747,
AL122049,
AF118064, I09360, AL133093,
AL133098,
A45787, U68387, AL133077,
AL080137,
AF081195, U88966, E08263,
E08264, E07361,
A93016, AL049300, AF210052,
AB007812,
AL122118, AL137283, AF111849,
E08631,
AL137480, X87582, E05822,
AF132676,
AF061981, AF061836, L30117,
AL117432,
Y07905, L19437, AF032666,
AR020905,
AL137705, AJ006417, AF008439,
X53587,
AL133665, AL023657, AL050092,
AL137294,
AF100931, E06743, AL137478,
AF051325,
AL137488, AL137292, AF067790,
AF126247,
X81464, and AL133081.
HLDBM06 112 12000041 - 1415 I5 - AW385660, AA809265, AA829492,
1429 F00820,
AL135576, F08230, AA312559,
AW021627,
AI287475, N22037, AI366993,
AA598551,
AA588001, AA363353, AI800168,
AI908093,
AI049508, AA730422, H72530,
AI207465,
AW303008, AW150077, AC005279,
AL034420, AC003035, AP000511,
AL031848,
AL023575, U47924, AC004087,
AC004848,
AC007314, AL022318, AF003626,
AC003049,
AL021578, AL031657, AC004638,
AC005753, AC004857, AC007546,
U62631,
AF053356, AC005088, AL135744,
AL034343,
AC005725, AC006538, AL133163,
AL133448, 270280, AP000130,
AL049776,
AC002367, AC005520, AL035106,
AC005920, AP000348, D87675,
AL022727,
AL031846, AL137100, AC004231,
AP000237,
AC009178, U52112, AC005562,
AC002072,
AC006115, AC006466, AC002538,
281365,
AC007057, AC005347, AC004797,
AF030453, AL021408, AC002996,
AF107258,
AL035045, AC007688, AL009181,
AC005015, AC006948, AC016026,
AC005071, AC007030, AL049869,
AC005832, AC005184, AP000208,
AC004167, AC007011, AC004790,
AC002300, AC006581, AL121754,
AC004832, AP000252, 282189,
AL008718,
369
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC006120, AC006531, AC005207,
AC006480, AC005409, AC000025,
U95740,
AC004985, AP000142, AL049569,
AL109809,
AL023653, AL03168I, AL096791,
AL034549,
AC000041, AL031737, 282214,
AC004813,
AC002461, AC005091, AL034548,
AL022328, AL009179, AB003151,
AL121595,
AP000134, AP000212, and AC004032.
HDPMT22 113 12164881 - 2012 15 - AA203281, AI623801, AI016523,
2026 AI673515,
AA838021, AI799476, AI832581,
AI590686,
AI921469, AI270295, AI673256,
AW085786,
AA603709, AI345677, AI561356,
AI573026,
AI357599, AW151785, AI174394,
AW 117903, AW089006, AW 189415,
AI446373, AI520702, AW263569,
AI470284,
AI284020, AI648567, AI826415,
AW009624,
AW084097, AW182790, AI620093,
AI860697, AW268261, AI873644,
AW081255, AI862144, AL037030,
AI365256,
AI554343, AW058233, AI873638,
AI648502,
AI475267, AW088899, AI648408,
AI250856,
AI570966, AI921254, AW193467,
AI636619,
AI886594, AI874151, AI434242,
AI933785,
AI540606, AI282967, AI249877,
AW409775,
AI452556, AI539153, AI885989,
AA464646,
AI491783, AI859464, AI472536,
AI636467,
AI161278, AI799199, AW 191844,
AI582912,
AW089179, AI609360, AW029271,
AI589428, AI677824, AI677797,
AI144116,
AI866082, AI470293, AI345735,
AI539781,
AI963216, AI539707, AL036980,
AW082588,
AI609181, AI886532, AW075207,
AI362637,
AI343037, AI095113, AW268072,
AW170663, AI281757, AI538342,
AW129080, AI701975, AI345114,
AI307210,
AW168373, AA761557, AI313320,
AI470714,
AI553645, AI313352, AI307503,
AI471227,
AI307736, AI873704, AI349814,
AI334893,
AW082532, AI689614, AI349266,
AI334452,
AI349787, AI345370, AW090451,
AI312146,
AI312339, AI309431, AI340537,
AI345745,
AW 169148, AI348854, AI345258,
AI345253,
AW081311, AI340511, AI307459,
AI860783,
AI269636, AW022494, AL036772,
AL036396,
AI311604, AI886055, AW021373,
AI824748,
AI271234, AI933992, AI343131,
AI312271,
AI349269, AI825956, AI888621,
AI310945,
AW 189424, AI696819, AW 193203,
AA070889, AL036652, AI650787,
AW082594, AI282376, AI818578,
AI889148,
AW193026, AI345737, AW088805,
AW074274, AI453413, AI613453,
AI345736,
AI669639, AI096613, AI282651,
AI349933,
AI345608, AI802372, AI471282,
AI752007,
AI636197, AI349598, AI251830,
AI569309,
AA848053, AI469516, AI912866,
AW168384,
AI910464, AA806719, AI554484,
AI539771,
AI929108, AI866608, AW085799,
AI436429,
AW082600, AI582871, AI473451,
AI963387,
370
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI863047, AI805688, AI537677,
AI283914,
AI696611, AI336662, AI249946,
AI890507,
AI345471, AI383919, AI805638,
AI366922,
AW079334, AI366549, AI636719,
AI382670,
AI832245, AI446405, AW130430,
AI282031,
AI582954, AI805769, AL046463,
AW072930,
AW082623, AW189777, AW301300,
AI560545, AI611743, AI344938,
AW088560,
AW 166865, AW083804, AA830821,
N98606,
AI951222, AI696626, AI284509,
AI811863,
AI244380, AI568765, AI589993,
AW149876,
AW059713, AI652028, AW151889,
AW 105455, AI917963, AI799195,
AI955945,
AI830187, AW151625, AI918554,
AA587590,
AI343582, AI307507, AF015958,
U00686,
AF040751, AF000145, A18777,
AL050138,
AL133637, AL133624, AL137523,
I48978,
I41145, U96683, AF169154,
S77771, U42031,
A52563, I89947, AF036941,
U90884, A08913,
A45787, I89931, AFI83393,
A08912,
AL117629, AL137294, A08910,
I49625,
AL080086, A08909, AF081197,
AF081195,
AR038854, A08908, X62580,
AL133645,
576508, E15582, I89934, AB019565,
AL133104, Y16258, Y16257,
E02756,
Y16256, I26207, AF113691,
AF022813,
AL080158, AL080127, AF113676,
X81464,
AF003737, U57715, AJ242859,
X84990,
AF030513, AL122111, AL049460,
Y11587,
AF107847, AF094480, Y14314,
E08631,
U77594, AJ006417, AF182215,
AC002467,
A08907, A08916, AF113694,
U75370,
AF017790, AF061943, U80742,
AL080137,
AL133619, AL133081, AF159615,
AR059958,
AL117585, AF061795, AL137712,
AF151685,
AL137547, AF016271, AL137550,
U72620,
AL122123, AF113689, AL122050,
AL133640,
AL122106, AF120268, X92070,
I09499,
AL133568, AL137527, AJ012755,
M92439,
AF205861, I89944, AL137463,
I46765,
L19437, X96540, AF151109,
AL050155,
A08911, I00734, D55641, AF111112,
AR068751, E03348, L13297,
A65340,
X87582, E05822, AF215669,
E02253, E03349,
L40363, X80340, AF061573,
AL137574,
E07108, AR059883, E00617,
E00717, E00778,
AJ003118, AL133014, AL137705,
X65873,
AF057300, AF008439, AF057299,
D83989,
A18788, AL137300, U75932,
AF012536,
U92068, AF065135, 272491,
E01812,
AL137554, AF090896, A12297,
X57961,
U91329, AL049465, AC004227,
AF162270,
E02152, AF091084, AL137429,
AF110329,
AL133067, AL137557, AL133093,
AL137271,
AB025103, X52128, AL137665,
U68233,
I92592, 568736, U87620, 569510,
AF158248,
AL122118, I29004, S61953,
AL080060,
AF114818, AL122049, AF118064,
AF118070,
AL137560, AF115392, AF111851,
AL110296,
371
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
L30117, AL133098, AL117460,
AL133557,
AB007812, AL133075, AL117435,
AL122045,
AF199027, AF180525, U72621,
AL133113,
X93495, AL133049, AL137476,
Y08769,
AF026816, AF031147, U00763,
575997,
AF104032, AL137556, I48979,
AR000496,
AF132676, U39656, AL080154,
AF061836,
AF192557, E01314, AL133016,
X72387,
AL110225, AL110222, AL137548,
AF113013,
Y10080, A57389, AL137526,
U49434,
AL049382, AR038969, AL117626,
I42402,
AL137538, AL122098, I66342,
A90832,
AL117440, AL137273, AL133072,
I68732,
AF078844, I09360, AF067728,
X98834,
M30514, AL137648, AF017152,
AL137256,
AF125949, ALI33077, AL050146,
AL137660,
AL117432, AF102578, and A93016.
HDPRN38 114 8836581 - 811 15 - AA232176, AA232159, H84466,
825 AA332911,
and AI765848.
HETKH30 115 8840091 - 925 15 - AA436699, AA442502, H25167,
939 AA306355,
H11845, and AA584520.
HPIBQ37 116 8842891 - 411 15 - AA101561, W76302, C17760,
425 AA227408,
AA215609, AA101519, AA626769,
AA359412, T73746, AI927392,
AF111713,
A91701, A91699, AF207907,
AF172398,
AF154005, and AB017568.
HE8DY76 117 11361141 - 2263 15 - AW341661, AA927475, AI127041,
2277 AI288214,
AA464813, AA431900, AA234267,
AI540222,
AA993059, AA255475, AI698915,
AA292658,
H89282, AA827655, AI685041,
AI038167,
H89283, AA256881, AA236364,
and
AF087980.
HSTBK14 118 8877151 - 380 15 - AA380041.
394
HE9RE21 119 11750671 - 1594 15 - AI589113, AL120391, AA224260,
1608 AA326268,
883178, AW136392, T78371,
AA317066,
AW410844, AW265468, AA533660,
AA601376, AL121039, AI702049,
AI572680,
AW419201, AI744963, AW162314,
AI609992, AI433952, AW148821,
AI064968,
AI744890, AL044966, AW072963,
AL133861,
AI242236, AW162332, AA315052,
N99245,
AW192930, AW272619, AI439525,
AL138262, AA610644, M77888,
AI445699,
AI285651, AW162762, AA525818,
AI567676,
AA362670, AI734076, AA425283,
AW057760, AA584360, AA779599,
AA112864, AA640305, AW148964,
AA507623, AA524604, AA493464,
AI734075,
AA676462, AW028376, AI052366,
AI150934,
892703, AI538404, AI133355,
AA579082,
AA502450, AW020094, AA199578,
AA657392, AA618132, AL133216,
AF098786, AF162762, AL049830,
AL009181,
AC004673, AC002072, AC005069,
AC000353, 293928, AL031585,
AL139054,
AC005726, AC004915, AC004453,
AL021918, AC007207, AL121593,
U91325,
U95743, AL035588, AB023054,
AC005520,
AL009I72, AC00490I, AL024498,
AP000036,
372
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL034423, 282201, AC007968,
292844,
AC005696, AC007567, AL049759,
AL049869, AC007539, AC004526,
AC006213, AL121653, U95738,
AE000661,
AL109627, AL117258, AL022345,
AL133162,
AC006017, AL022165, AC005828,
AF042091,
AC012384, AC006080, AC004944,
AC006208, AC007262, AF207550,
AL121754,
AF186194, AL031432, AC006141,
AC003041,
AC004125, AL034402, AL021391,
AC005138, AC004253, U91321,
AC004206,
AL02099I, AC006948, AC004659,
AP000099,
AL021877, AC002452, AC008044,
AL021392, AL050308, AL035420,
AC002040,
AC005066, AP000514, AL031575,
AC004966,
AP000260, AC003024, AC007151,
AL096775,
AC004048, AL031665, and U91327.
HKACI15 120 892363 1 - 179815 - AI241578, AI955238, AI312113,
1812 AW338261,
AI979207, AI925871, AI333843,
AW009598,
AA741250, T86963, AI590808,
AW 190875,
AA244018, N20044, AA101562,
AA149993,
AW192453, AA152150, N28398,
AA483522,
T40695, AI093487, AA224590,
AI263270,
. AA244075, 872982, AA101561,
T87045,
AI193265, 801692, AI469580,
AI632044,
T84017, W76302, AI002582,
828222,
802633, AA101520, AI864718,
T39606,
AA304161, AA702259, AI608881,
827969,
C75490, T39607, T84016, C75621,
AA861308, AA890390, AA486163,
AA486100, AA513370, AA404390,
AA227408, AA641435, T73746,
AI687737,
AA215609, AI890283, AA642887,
F31670,
AA101519, AI799264, C17760,
H57108,
AA768079, AW085811, AI304788,
AI935684,
AI934664, AI815425, AW339937,
AW277240, AF207907, AF111713,
AF154005, AF172398, A91699,
A91701,
AF111714, AC005527, AC005529,
. AC002073, AC005519, AF207550,
L81576,
AC008498, AL035445, AL031311,
AC005914, U63721, AC007421,
AP000692,
AC005358, AC005730, AJ246003,
295116,
AL031681, AF109907, AL020997,
AC005696,
AC000353, AC007637, AC004913,
AL139054, AC002310, AC002991,
AC004953, AL049795, AC005412,
AC000025, AC007263, AC005575,
AC002036, AC007390, AL121658,
AC007536, 268756, AP000512,
AL109963,
AC003086, and AF015416.
HRDBE43 121 894862 1 - 186815 - AI160324, AA420500, AW263972,
1882 AI206613,
AI417744, AI953056, AA778217,
AI863306,
AI804393, AI432712, AI587218,
AI218649,
AI339726, AA780366, AI825578,
H70209,
AA470738, AI669249, H70546,
AI611674,
AI792038, 808140, T82124,
AI791228,
AI820643, AA847657, AI342131,
AI342141,
AA989292, AI631664, AI697858,
AI697880,
373
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI278251, and 884867.
HSSKD85 122 9081411 - 113615 - AW024960, AI479960, AI052585,
1150 AI139986,
AA135576, AW137104, AW205456,
N30762,
AI631818, AI187156, AA830014,
AI452434,
AA634216, AW088488, AA398256,
AI859053, AI088449, AI159823,
AA564062,
AI494095, AA158516, AI311717,
AA811798,
AA226160, AI873741, N25872,
AA146624,
AA761003, AA190958, AI066392,
AA535733,
AI278434, W92242, AA225625,
N40580,
H94758, AI382438, AI796467,
W92243,
859937, H94384, H94363, AI969940,
W70120, AW338143, W99328,
AA143555,
AA399431, AA190865, N45043,
AI718153,
AI245054, AI906964, AI760352,
AA135514,
AA653523, AI708811, AA034276,
W69970,
AA156400, M93661, D32210,
and U57368.
HFOXL77 123 9106981 - 602 15 - W22070, AB033063, and AR065869.
616
HBXCZ29 124 9108421 - 823 15 -
837
HNTMB90 125 9109341 - 718 15 - 299396, AL038837, AL037051,
732 AL036725,
AA631969, AL039074, AW392670,
AL036418, AL039085, AL039564,
AL036858,
AL039156, AL039108, AL038509,
AL039109,
AL039128, AL036924, AL037094,
AL039659,
AL038531, AL036196, AL039625,
AL039648,
AL045337, AL036767, AL119497,
AL037082,
AL037526, AL036190, AL038447,
AL119483,
AL037639, AW372827, AL039678,
AW363220, AL039629, AW384394,
AL119457, AL039423, AL036238,
AL039150,
AL119319, AL040992, AL119324,
AL042909,
U46350, AL038520, AL119484,
AL119391,
AL037077, AL119443, AL119522,
U46351,
AL119355, AL119363, AL037726,
U46341,
U46347, U46349, AL134533,
AL039410,
AL038851, AL119341, AL134531,
AL119335,
AL119418, AL119396, AL039386,.AL036998,
AL036733, AL119496, AL037615,
AL119439,
AL036268, AL037085, AL119401,
AL119444,
AL037205, AL037027, AL037178,
AL045353,
U46346, AL036679, AL042614,
AL036765,
AL042965, AL042975, AL134528,
AL134538,
AL042984, AL036191, AL119399,
AL134920,
AL042544, U46345, AL036719,
AL043003,
AL043019, AL042542, AL042551,
AL042450,
AL043029, AL134542, AL134532,
AL037021,
AL037054, AL036836, AL036158,
AL119464,
AL036774, AL036886, AL036999,
AL036964,
AR066494, AR060234, AR023813,
AR064707, A81671, AR069079,
AB026436,
AR054110, and AR064706.
HMI~CH92126 9109361 - 789 15 - T78768, 813299, 814933, AB003592,
803
D87248, AC018833, AC034192,
AC026206,
AC026206, AC022381, and AC022381.
HTELV86 127 9109461 - 108615 - AI272244, AA382531, AI809639,
I 100 U35371,
and X99043.
HNTAF23 128 9109471 - 239 15 - AW392670, AL119355, AW372827,
253 U46341,
AL119483, AL119319, U46349,
AL119457,
AL119324, AW384394, AL119497,
374
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW363220, 299396, AL134920,
AL134524,
AL119484, AL119363, AL119391,
U46350,
U46347, U46351, AL119443,
AL119444,
AI142137, AL119341, AL134538,
AL119439,
AL119522, AL119396, U46346,
AL043029,
AL037205, AL134531, AL119335,
AL042614,
AL119399, AI142139, AL119496,
AL134533,
AL119418, U46345, AL043011,
AL042984,
AL043019, AL042544, AL042896,
AL043033,
AL042965, AL042975, AL042450,
AL042542,
AL043003, AL119464, AL042551,
AB026436,
A81671, AR060234, AR054110,
AR066494,
AR069079, and AR043113.
HDDAF49 129 11278771 - 893 15 - AL133047.
907
HHEZT58 130 9114161 - 544 15 - H29349, AI989604, AI023283,
558 and
AL049552.
HETEY43 131 12276461 - 232515 - AA416825, AA004273, AI694002,
2339 AA994178,
AW028389, AW005600, AI028762,
AW361145, AW005609, AA416694,
AA872644, AA159854, AA398414,
AI588937,
N45311, AW074429, AA812539,
W16858,
AI362984, AW385193, AI168838,
AI378368,
AI347827, AI905632, N91133,
W20422,
AA158737, N50437, AW371259,
817090,
AA989438, AA641286, AA007287,
243294,
AI867088, AA161059, 807447,
AA888152,
AA938635, AA552691, AA055511,
N54761,
AI540615, AA403066, AA515605,
AA856599,
AA055512, AA161002, H15805,
D20199,
817091, 862201, AA977374,
AA677972,
AI302293, 807448, F07754,
F02724, W31874,
240838, 864586, AW081002,
AI005604,
AA382937, AI660382, AA854985,
AI273668,
AA978325, AI298846, AI190563,
AI352446,
AI016243, AI217130, AI566458,
AI308866,
AI138836, AA235342, AI468643,
AA258375,
N90300, AI266090, AI572259,
AA039698,
N74691, AI198802, AA706102,
AA815326,
AA729427, AA554340, AI082197,
H97816,
AI305205, AA534840, AA722577,
AI094340,
AI240390, AW084656, AW297272,
AI680152, AA936948, AA890213,
AA828297,
N92285, AI277971, AA828311,
AI689585,
AI122587, AA642550, AI369540,
AI220817,
AA436858, AA992749, N69914,
AA749389,
AA406268, 816087, AA401493,
AI378158,
AA843464, AI041701, AI017781,
AI033835,
AI918112, AA885965, H96077,
AA683524,
AI090938, H41782, AL133017,
AR031994,
and L40410.
HWHQR10 132 11377701 - 111315 - AW003215, AI989557, AI653400,
1127 AA176800,
AI283706, AI637491, AA581386,
and
AC004235.
HAUAI17 133 9216741 - 101015 - AI742586, AI823636, AI738645,
1024 AI570505,
AA994212, AW166260, AI472051,
AI689840,
AI819324, AI802140, AI808204,
AI018575,
AI708063~ AA044874, N33369,
AI458889,
AI798664, AI694439, AI742084,
AA996109,
AI268684, AI051014, AI005161,
AI126407,
375
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW295897, AI625938, AW418896,
AA044826, AI564776, AA983545,
H92520,
AI379936, AI373261, AA317357,
AW139306,
AI521441, AI264270, AI498702,
AI244808,
AI948596, H77889, AW 135452,
AI021975,
AI985535, AW242712, 800296,
AA677354,
N35293, AA938619, AI948603,
H58937,
AA917514, AI393979, AA779970,
AI768427,
AW044210, W25595, T99948,
AA883635,
AW072204, AI470848, AW351592,
AW020604, H92521, AI955919,
AI208112,
AI919367, H58984, AA335622,
AI3Q8950,
AF126781, and AI085468.
HORBP08 134 12209031 - 5755 15 - AI917724, AI342006, AI261611,
5769 AI750970,
N33407, AI825646, AA482392,
AI459225,
W47029, AA971699, N44869,
W47220,
AA284278, AI905640, AI905601,
AI005408,
AI806281, andAW137913.
HKGDI91 135 11112811 - 969 15 - AI952995, AW071872, AW297176,
983
AW131657, AI871511, AI568544,
AI884982,
AI887085, AI214075, AW295595,
AI356220,
AW297665, AW006191, AI423713,
AI383368, AW294321, AI363919,
F31634,
AI133083, AI523477, AI096714,
F23268,
AI620666, AI469468, AI627917,
N55515,
AI378437, T05617, AA565911,
T90931,
AI671077, 870884, AA077886,
AI905408,
AA932787, AW084967, N48099,
AA081770,
AI445774, AW237905, 870883,
AI859744,
AI758858, AA612727, AI929298,
AI929825,
AW242279, AW157180, AF084576,
AC002351, AC008039, AC004655,
AC005777, AF196779, AL009181,
AL031848,
AC006236, AC006064, AC005952,
AF165926, AC007193, 297989,
AL020998,
AL049780, AL008718, AL034429,
AC006449,
AC004770, AC005191, AL034423,
AL050308, AC004000, 285996,
AF207550,
AC006530, AL008582, AC007277,
AC005969, AC004217, AC004827,
AC004812, AL024508, 298950,
AC007546,
AL035685, AF015416, AL049829,
AL023653,
AP000248, AL035450, AC008268,
AL022149,
AC010205, AC005409, AC000134,
AC005765, AC006059, AL049843,
AC007263, AC004526, AL122020,
AC004616, AB003151, AC007544,
L48038,
AC009542, AC005803, AL031427,
AC005043, AL117694, AC009330,
AP000704,
AC007066, AF196969, 284469,
298884,
AF195658, AC007021, AC004254,
AL035462,
AC005668, AC012085, AC005695,
AC004914, AC000026, 294056,
297195,
AC003690, AC004841, AL096766,
AL034420, AC004228, AC007686,
AL049759, AB023048, AL035417,
AC005318, AC012384, AC004522,
AF095901, AL022323, AC004882,
AC004030,
' AP001063, AC007040, and AC006254.
376
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HNHNP81 136 9283781 - 604 15 - D51060, 014014, D58283, AA305409,
618
D80253, D80024, D80166, D59619,
D802I0,
D80240, D80366, AA514186,
014389,
D80043, D81030, D80133, D80247,
D598S9,
D80212, D51799, D80164, D80219,
D51423,
D80022, D80391, D59787, D80195,
D80188,
D80248, 014331, D59502, D59467,
D57483,
D59275, D59610, D80227, D81026,
D50995,
D80196, D80439, D80251, D80269,
D59889,
D51022, D50979, D80268, D80522,
015076,
D59927, AA305578, D80038,
D80193,
D80045, D80241, AA514188,
AW360811,
D80378, AW177440, D80302,
005695,
014429, AW178893, AW377671,
AW375405,
D80157, T03269, 075259, AW
178906,
AW179328, AW366296, AW360844,
AW360817, D59373, AW375406,
D51103,
AW378534, AW179332, AW377672,
AW 179023, AW 178905, D51759,
AW360841,
AW378532, D58253, AW177731,
AW177501,
AW177511, D80132, D80134,
AW352171,
AW377676, AW352170, AW178907,
AW378528, AW178762, AW179019,
AW 179024, D51250, AW 176467,
AW 178983,
AW177505, D81111, D59653,
AW179020,
AW178775, AW367967, AW369651,
AW178909, T48593, AW177456,
AW179329,
AW178980, AW1789I4, AW177733,
AW 178908, AW 178754, AW
179018, 006015,
AW352158, AW352117, D80949,
AW178774,
D59695, D52291, D45260, AW352120,
D59627, D51079, AW179004,
AW179012,
AW378525, AW352163, F13647,
AW360834,
T11417, D80064, 221582, D80168,
014298,
AW378543, AW352174, D80258,
AW177728,
H67854, 014227, AW179009,
AI525923,
AW367950, AW178911, AW177722,
D59503,
AI910186, AW378540, 003092,
H67866,
AA809I22, D51221, AW178781,
D58101,
AI905856, D58246, AW177508,
014407,
D80228, AI525917, 014077,
AW178986,
AW177497, T03116, AI535686,
AI535850,
D59317, D51213, D80014, D59474,
AW 177734, AI525920, D45273,
AW 177723,
014973, 014344, AW378533,
AA514184,
D59551, 014957, AI525215,
D60010,
AI525235, D60214, AI525227,
014046,
AI557774, AI557751, AI525912,
T03048,
AI525925, D51097, AI525242,
AA285331,
AW378542, AI525222, AW378539,
230160,
016955, 005763, 233452, T02974,
D51053,
AW360855, H67858, AI525237,
004682,
D50981, T02868, 013958, AI525928,
D80314,
AI525238, A62298, AB028859,
ARO18I38,
AJ132110, A62300, AR008278,
A84916,
AF058696, A82595, AR060385,
AB002449,
D89785, X67155, Y17188, A94995,
D26022,
Y12724, A25909, A67220, A78862,
D34614,
AR008443, I50126, I50132,
I50128, I50133,
377
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
D88547, AR066488, AR016514,
AR060138,
A45456, A26615, AR052274,
X82626,
Y09669, A43192, A43190, AR038669,
AR066487, A30438, I14842,
AR025207,
AR054175, D50010, Y17187,
AR066490,
AR008277, AR008281, A63261,
I18367,
AR008408, AR062872, A70867,
AR016691,
AR016690, U46128, D13509,
A64136,
A68321, AR060133, AB012117,
I79511,
X68127, U79457, AF123263,
AR032065,
282022, A63887, and AR008382.
HFIDL68 137 9284751 - 516 15 - AI375172.
530
HLWFG82 138 11823181 - 595 15 - AI802325, AI161267, AW170791,
609 AI885931,
AI660388, AA219338, AW410057,
and
556581.
HCHON59 139 9310821 - 240115 - AW299683, AW152065, AA315514,
2415
AA305116, AI961078, AA210776,
AW236710, AA622988, 856767,
W04752,
AA781427, 825303, 889462,
896008,
818161, N76920, AA694165,
824760,
AA740627, 219446, AW074408,
AA345403,
AI076025, AA348726, T86393,
AA875871,
AI224620, AI916251, T99947,
AA337010,
AI077381, AA749291, H17194,
T79510,
AA004316, AA363905, AA815288,
225140,
AW044490, 889463, 817355,
H17900,
T98732, AA054853, AW085956,
AA211903,
AA716584, AW297867, 220433,
AA133996,
895999, H52630, AF029260,
and A74519.
HEEAR06 140 11259131 - 928 15 - AA776394, AA441900, AA678805,
942 AI076730,
898499, AI247998, 898454,
AA180838,
AA180179, AI039158, AA211777,
and
AL137493.
HHPTE06 141 11822781 - 279915 - AL118673, AW 149579, AA776056,
2813
AA490022, AA302827, AB017139,
AJ132999,
and AJ132998.
HCHNJ32 142 12191151 - 898 15 - AI991112, AI573258, AI589871,
912 AI382182,
AW168298, N63300, AW245578,
AW245568,
N30214, AI244679, AA442766,
AI015935,
AA625514, AA714315, AA613669,
AI669114,
AA433946, AA568688, AI808444,
N63050,
AA813327, AI281530, AI885837,
N52392,
AA811995, AA492250, AA507560,
AI221056,
AI083879, AA720021, AA446582,
AI557529,
AI085835, AI557530, AI304532,
AA313563,
AA305352, AA838602, AA430753,
AA573777, AI304455, AA782093,
AA446709,
AI690776, T73332, AA885566,
AA573537,
AI566973, AA720002, AA861893,
AI283278,
AI304454, AI199547, AI160878,
H72469,
AA531050, W00555, AI472891,
W00611,
N32117, AI937637, N54353,
H78356,
H95032, AI57I328, T6I807,
AA876623,
AW204782, N78252, H65466,
AI004311,
850529, AW138834, F21642,
H64869,
AA086353, AI264256, AA652483,
AI859175,
H85048, AA418354, AA501347,
T61353,
AA134203, T55136, H91692,
AA431169,
T60510, AI141454, 230219,
AI985397,
378
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
H93999, AA855127, 850625,
H72870,
AA291581, AA293323, AI858739,
T73417,
AW150864, C00330, H73548,
H91789,
T98646, AW300104, 886214,
AA432189,
AI382568, H77954, AA918480,
T73347,
T72288, AA478304, N59791,
AI251780,
F15963, AA478363, T72293,
AW207071,
T71510, AA230200, AI918444,
AI927580,
AA134202, N88648, AA974081,
AI954738,
AA429728, 220777, N72798,
N56787,
AA541321, AA641099, T73399,
T71348,
H84670, T98698, AI567583,
AI126088,
AW440575, H78357, T72864,
AA983562,
220778, N40867, AA229346,
H47484,
_ T71167, AA230291, T72848,
AI470293,
AI570966, AL042384, AW168823,
AI358042,
AI805688, AA603709, AI869377,
AI567637,
AI697324, AI335426, AI348777,
AW148716,
AW 189415, AI241792, AI678762,
AW262565, AI537617, AI800453,
AI500039,
AI624293, AI932818, AI648684,
AI345688,
AI494201, AI249877, AL040241,
AI623682,
AI446124, AI680280, AW 169624,
H42825,
AA464646, AI573026, AW058233,
AW130849, AI570997, AL046356,
AW117919, AI249962, AI310500,
AI699011,
AI567944, AI285586, AW088899,
AI682891,
AI539153, AI865334, AI280661,
AI950688,
AI919345, AI612813, AW089258,
AI701975,
AI073952, AI610645, AI696819,
AI537837,
AI783861, AI468872, AI680498,
AI364788,
AI698401, AL037558, AI587606,
AI336575,
AL079960, AI926878, AW088903,
AW151714, AI933992, AW129230,
AI567612, AI866770, AA848053,
AW059713,
AI866082, AI589428, AW085786,
AI934276,
AI539771, AI811344, AI829990,
AI677797,
AI625464, AW191844, AI249946,
AI862024,
AI866469, AW265004, AI859464,
AW021373, AI918500, AW 193203,
AA613907, AL039390, AI922577,
AI874151,
AF113123, AR009500, A74991,
A74992,
AL080127, X93495, AL122098,
I26207,
I89947, I48978, AF183393,
AL117432,
X84990, A18777, AF087943,
282022,
AL050393, AL133067, E03348,
E03349,
AR059958, AL137463, AF111851,
I17544,
AL122111, A08916, A08913,
AL137705,
I89931, 568736, A08912, A08910,
I49625,
X79812, A08909, AB007812,
AL133010,
AR038854, A08908, Y10080,
AF012536,
AL049382, X80340, AF159615,
AL133014,
U72620, AR011880, AL137556,
AL122118,
X53587, AL080074, I03321,
AL117578,
561953, I48979, M27260, AL122093,
AJ005690, AF119337, AL137526,
AL110197,
AF017152, U96683, AL049465,
AL080137,
AL080148, AL137300, AF111112,
AF162270,
AF113019, AF065135, 569510,
AF030513,
379
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL122121, AF08I197, AF08I195,189934,
I89944, AL110221, AF017437,
Y11254,
AL133645, U49434, AF113691,
AL110222,
AL137557, AF090900, AL137480,
AL137476,
AL080060, AF113689, AR038969,
AF113677,
A65340, AL133093, AF118070,
AL122050,
AL080154, I42402, AB025103,
X52128,
AL1377I2, AF113676, AF158248,
U80742,
AL133565, AF026816, AB019565,
AL122110,
AF003737, AF100931, AL122049,
I09360,
AF067728, YI I587, E15324,
U58996,
L30117, AL133077, AL117440,
AL117435,
U35846, A03736, AF182215,
AL110280,
A21103, AL137429, L19437,
X87582,
E05822, AF132676, AL133640,
AL137271,
AL122106, AF061836, AL137538,
AL133075,
A45787, I66342, AL137547,
AL137527,
AL137294, AF000145, X72889,
576508,
A18788, A93016, E04233, Y08769,
AF106697, AF061795, AF151685,
U00686,
AL122045, AF040751, AL137658,
AL050277,
AF113694, AF114170, X00861,
536676,
AL050138, AF051325, AL049452,
AF114818,
A07647, Y14314, E08631, AL137558,
AL080140, AL080124, AL080086,
AF067790,
AF1I3690, AF028823, AL133558,
AR000496,
X62580, AL137560, U39656,
AL133081,
AL133557, U42031, 237987,
AL122100,
AL137711, Y09972, AL133016,
AF146568,
AL133113, 577771, A12297,
AF102578,
I68732, I41145, AL133104,
ALI37478,
AL117585, E01314, U77594,
AL137273,
AL117394, AF137367, AF104032,
X81464,
A08911, AB016226, AF118064,
U67958,
AL080159, AF210052, AL133098,
AF153205,
AL080I58, X92070, U87620,
AL096744,
AJ003118, AF061981, AL133568,
E15569,
U78525, A52563, E02221, AF106862,
297214, AC002467, AL049460,
A08907,
X72387, AF215669, U00763,
AL137640,
ALI37574, AF125948, A08915,
579832,
AF106657, AL050092, AF113013,
AF022363,
100734, AF078844, Y10655,
AR019470,
AR029490, AA418240, AA522761,
and
AA938645.
HCECQ23 I43 9383981 - 796 15 - AI480182, AI500178, AI873131,
810 AA322958,
AA322718, AI936088, 885125,
890888,
H05353, AA338672, H51247,
835934,
AW 139057, H05303, 849451,
842549,
H29245, AI654790, AI638508,
851648,
AW149807, 844423, AI458144,
AI419465,
F02105, AI499775, 240525,
F09051, 885080,
H51217, AI569283, D29763,
D64009, and
D64010.
HETIY94 144 12004801 - 2356 15 - AI821661, AI734047, AI766035,
2370 AA424839,
AA425730, AA723343, AC005317,
AC004772, AC005316, and AC007011.
HNHCP79 145 5657811 - 288 15 -
302
HEOOA49 146 9425611 - 731 15 - AW373840, 815032, and T97932.
745
380
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HFKKN77 147 9437571 - 719 15 -
733
HLCMP75 148 12137921 - 1758 15 - AA595199, AI339553, AI041943,
1772 AI2849S1,
AI652283, AA430329, AI290327,
AI087248,
AI961855, AI952525, AA730621,
AI081192,
AW166405, AA747653, H12557,
855548,
AI081393, 855547, H28600,
AI695272,
H26634, AA853085, T55811,
AI367028,
AI968594, AA430355, AI468799,
H19258,
AI864807, T55383, H26693,
H00825, H27260,
823780, AI783755, F22336,
AW204995,
C15076, D59467, D80164, D80045,
C14331,
D81026, D59787, D59927, C14389,
D51799,
D80227, C14429, D80195, D59275,
D81030,
D80269, D59502, D80038, D58283,
D59859,
D80022, D80166, D51423, D59619,
D80210,
D80391, D80240, D80253, D80043,
D59610,
D80212, D50979, D80193, D80196,
D80188,
D80219, D57483, D80378, H12800,
D80366,
D50995, D59889, D80241, D80251,
D52291,
AW 177440, AA305409, D80024,
AW378532,
D51022, AA514188, AA305578,
T03269,
D80522, AW178893, D51060,
C75259,
C14014, AW179328, C14407,
D80248,
T11417, D51250, AW3521S8,
AI557751,
AW369651, D80134, AW 178762,
AW 178775,
AW177501, AW177511, AW377671,
D58253,
AA514186, D80133, AW176467,
AW360811,
C05695, AW352117, F13647,
AW361580,
AW375405, D80268, AW378540,
AI910186,
AW366296, AW360844, AW360817,
AW375406, AW378534, AW179332,
DSI213,
AW377672, AW179023, AW178905,
D80132,
D80302, AI905856, C0601S,
AW352171,
D80439, AW377676, AW178906,
AW352170,
AW177731, AI535686, AW178907,
AW179019, AW179024, D59373,
D80247,
AW177505, AW360841, AW179020,
AW178909, AW177456, AW179329,
D51103,
AW 178980, AA809122, 221582,
AW 177733,
AW378528, AW 178908, AW 178754,
AW179018, AW360834, D81111,
D80157,
AW178914, AW352174, AW179004,
AW 179012, D80014, AW378525,
D51759,
D51097, C14227, D80258, D59627,
AW177722, AW177728, AA285331,
AW 179009, AW367967, AW 178774,
AW178911, AW378543, AW352163,
T02974,
N71226, AW178983, AI557774,
AW352120,
AW178781, T48593, D58246,
D59503,
D58101, AW177723, D59653,
AI535850,
D59317, D45260, C14344, AW177508,
AW367950, D80168, H67854,
C03092,
C14975, H67866, AI525923,
AW378533,
D80064, D59551, AW178986,
AW177497,
T03116, AI525920, N66429,
D45273,
AW 177734, AI525917, D51079,
D80949,
A84916, A62298, A62300, AR018138,
Y17188, A82595, AJ132110,
AR016808,
AF058696, A25909, X67155,
D26022,
381
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AB028859, A67220, D89785,
A78862,
D34614, AR008278, X82626,
D88547,
Y17187, Y12724, I82448, AR025207,
U87250,
A94995, AR060385, AB002449,
X68127,
AR008443, AB012117, A30438,
I50133,
I50126,150132, I50128, I19525,
A85396,
AR066482, AR066488, AR016514,
A44171,
A85477, AR060138, A45456,
A26615,
AR052274, A86792, X93549,
A43190,
Y09669, A43192, AR038669,
U79457,
AR066487, I14842, U46128,
AR066490,
AR016691, AR016690, D88507,
AR054175,
I18367, D500I0, AR008277,
AR008281,
A63261, AR008408, AR062872,
A70867,
AF135125, I79511, D13509,
A64136, A68321,
AR060133, AB023656, AF123263,
AB033111, AR032065, AR060382,
X93535,
AR008382, and AW594568.
HDTB048 149 9450831 - 505 15 -
519
HWHQR25 150 11339211 - 242815 - AW274822, AI819931, AI655579,
2442 AI339445,
AI825674, AI160980, AW 189842,
AW072549, AI553935, AI307188,
T07963,
AA503743, AA594360, AA723221,
AI768795,
AA235839, AW276275, AA258721,
T33811,
AA526945, T07962, T33770,
AW081414,
AA258559, 832712, AA351359,
AI962815,
AI470455, AI478830, 832711,
AI739631,
AI191246, AA887961, AL119319,
AL042551,
AW392670, AL119483, AL119484,
AL119324, AL134531, AL119497,
AL119355,
AW384394, U46351, U46349,
AL119457,
AW363220, AW372827, 299396,
U46341,
AL119363, AL119391, U46350,
U46347,
AL119443, AL119444, AL043029,
AL134920,
AI142137, AL119341, AL134538,
AL1I9418,
AL119439, AL119522, AL119396,
U46346,
AL119399, AL042450, AL119335,
AL134533,
AL037205, AL042614, AL134524,
AI142139,
AL119496, AL042975, U46345,
AL043011,
AL042984, AL043019, AL043033,
AL042544,
AL042965, AL134542, AL042542,
AL042896,
AL043003, AL119464, AB026436,
AR060234, AR054110, A81671,
AR066494,
AR069079, and AW594704.
HBGMZ39 151 9471121 - 588 15 - AI820661, AI791493, AA989356,
602 AI791282,
AI732537, AI792053, AW207804,
822360,
872427, AA505927, 822019,
872474,
AC008537, AC008537, AC008537,
AC019337, AC019337, and AC019337.
HSDFT51 152 11263341 - 135015 - AI422221, AW269213, T11456,
1364 H84186,
AI657002, AI142300, AI348147,
AA705920,
AA928672, AW028877, AI587025,
AI765590,
AA731378, W03281, AI954911,
AI936593,
AI355533, AI244341, AW173240,
AI797712,
AI219155, AW303951, AI696467,
AI148012,
AW148668, AI004666, AC004874,
U91321,
AC004804, 299291, AC004106,
AP001067,
AC003087, AC004887, AC008149,
AL133249, AP000966, AP001068,
AL023285,
382
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL021921, AJ011930, AL023586,
U95738,
AL022578, AL031056, AL133238,
AC006390,
AC005186, AL008733, AC006952,
AC004551, AP000952, AP000132,
AP000210,
AC006013, AC004448, AL022148,
AL079352, AP000248, AL031286,
AC002523,
297987, AL078615, AC006556,
U91319,
AC003091, AC002492, AC004009,
AC005406, AC000393, AF188024,
AL021329,
AC005066, AF003528, AL109865,
AL133321,
AC009802, AL035246, AC006926,
AC002301, AC002468, AC005598,
and
AF015416.
HS2SH04 153 11653541 - 1434 15 - AW337526, AA557790, AI270370,
1448 AI792092,
AI821056, AI821805, AA833896,
AA833875,
AA747757, AA603264, AL031291,
AF134726, AC006040, AL022163,
AC004217,
AL049872, AC007308, AC007201,
AL049764, AC006312, AL020995,
AC002470, AL135783, AC004230,
AL009181, AC006965, AC005914,
AC004967, AL035587, U95743,
AC007686,
AC004019, AP000114, AP000046,
AP000347,
AL050312, AC004953, AP000302,
AL050341,
AP000692, AC005399, U95090,
AC007298,
AL022316, AC002316, AC005529,
AL049776, AC004167, AC004408,
AF001549,
AC004991, AC002994, AP000030,
AP000212,
AP000134, AP000550, AC005971,
AC005670,
AC008018, AC007938, AC009721,
AL049646, AC002477, AL031602,
AC005015, AP000513, AL035414,
AL034420,
295113, U85195, AC005064,
AL 133312,
Y10196, AC005081, AE000658,
299716,
AC002351, AC008044, AP000251,
AC007014, AC007277, AL022398,
AC004859, AC005031, AC007227,
AC005215, AC005924, 295152,
AC004820,
AC002303, AC003104, AL021397,
AC005288, 285986, AC004834,
AP000346,
AL135744, AC007021, AC005291,
AF107885,
AL078638, AF088219, AC002549,
AF196779,
AC005740, AC004797, AC008085,
AC000052, 284469, 283844,
AC004883,
AC005089, AL021546, AC005519,
AL022394, AC005057, AL049869,
AL022320,
AL034548, AL024498, AC007371,
AC007664, AC005212, AC004998,
AL136295, AC000025, AL050348,
AL031662,
U91321, AC006026, AC006019,
AC005527,
AC005939, AC006001, AL049636,
AC006241, AC004812, AL049538,
AC003070, AL132641, AC005224,
AC004753, AC004695, 285987,
AC004979,
AC006571, AP000356, AC002352,
AC006208, AC002996, AC005486,
AC005082, and AP000501.
HETGL74 154 10654051 - 493 15 -
507
HLKAB61 155 9480021 - 284 15 - W70120, W99328, AI139986,
298 AA135576,
383
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA399431, N45043, AA226160,
AA143555,
AW024960, AA190958, and M93661.
HCEMK49 156 11694381 - 958 15 - 821312, AA323594, AI423098,
972 T04913,
N28363, AI885615, X75887,
228367, I44675,
X87096, I44674, X86406, X79881,
U37142,
and I44676:
HAJAV28 157 11861491 - 162115 - AA913364, AW027373, AW305275,
1635
AI799031, AW117480, AA588138,
AA775450, AW 190848, AA411334,
AA866178, W61038, AA411335,
AA775769,
AA769134, AA075643, N30274,
AA627544,
AI493881, AI147666, AA075644,
AA614747,
N30309, AA812101, AI025647,
AA868924,
AW339918, AI140386, N94919,
AI143201,
AI347094, AI138196, AA284960,
AI933338,
AI343592, AI128292, AI017993,
AI492556,
N20511, N41996, N42630, W72001,
W69402,
AI554835, AI679099, AA040263,
T32745,
AA872581, N29505, AI354734,
AI268560,
AI017992, F28362, AA448442,
AI679673,
AA863176, AA719956, AA444022,
AI142803,
AA732322, AI304774, AI475118,
AA993672,
AI624135, AA846235, W44314,
W44778,
AA305351, W37097, AA682603,
W65308,
AA448307, AW274816, N25416,
AI339799,
AI128110, D79265, AI004213,
AA285117,
AII49185, AI285067, AI872626,
AII86604,
AA557809, AA444000, AI344717,
AA922743,
N56641, AA996037, H13966,
AA515842,
F37123, AA732278, AA989130,
W65338,
W76570, R2I057, N26843, AA721150,
AI239957, AI580506, 896887,
AA034909,
W45686, W69363, F09166, H12989,
W19542,
N57447, 896888, C04314, AW183468,
H87003, AI719584, 824370,
T35889,
AI685763, AA081676, T34115,
N40568,
AA010732, AW023063, N63592,
T35834,
AW089136, AA913531, 242311,
F11505,
T35841, T30076, H05630, AA863208,
AA505347, T30517, H27007,
AI366940,
242248, F09167, H87002, W56871,
T36163,
AA040400, W19619, AA721261,
AA649338,
F34780, T35871, 846237, H13965,
AA913094, T35833, AA034976,
AA890331,
AI274646, N63619, AA082031,
F05477,
AA603299, AA322616, AA603386,
827044,
238484, AI564372, AI859366,
F01840,
827043, 827029, 827028, AA748381,
F01739, AA355325, AI859362,
H53598,
N46608,AA339209, andAF190797.
HETBR74 158 9486671 - 863 15 - AI424957, AA865175, AI345105,
877 AW337653,
AI493383, AA9921 I7, W86236,
AW0019I3,
T23935, AII41791, AI277560,
T33653,
T91218, AA469060, AA148613,
AI635951,
AI500569, T72018, AI290957,
AA159337,
T32385, AI088662, AI140973,
AA534837,
F10818, AI703234, AA486780,
AI935264,
AA999981, T94771, H50506,
AA774208,
T98781, H51340, H43580, N57875,
AI696236,
384
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
H44933, N64109, N40952, and
AL137633.
HSDJM56 159 9486691 - 799 15 - D57175, and AC009524.
813
HCWEI19 160 11377951 - 289 15 -
303
HLDOA63 161 11747951 - 744 15 - T46901, T74588, AI868831,
758 AL047042,
AL121270, AI568870, AI433976,
AI349772,
AW103371, AL135661, AW195957,
AW162071, AI678302, AI702406,
AL047763,
AW268253, AL119049, AI349933,
AI969567,
AI439087, AW117882, AI250293,
AI349256,
AI436456, AI064830, AW274192,
AI815383,
AW301409, AI312152, AI349937,
AI349645,
AI500553, AL121365, AI687728,
AI673256,
AI857296, AI440426, AI863014,
AW071349,
AI340582, AW238730, AI281779,
AI538716,
AI349004, AL036146, AL036396,
AW074993,
AI679724, AI521012, AI500077,
AI498579,
AI345735, AI567632, AI567351,
AI866608,
AL045500, ALl 19791, AI433157,
AI568854,
AI690751, AL046849, AI633419,
AW089572,
AI540832, AI613017, AI686926,
AI249257,
AI702433, AI366549, AI343112,
AI275175,
AI906328, AI608667, AI697137,
AW303152,
AW071417, AI207510, AW169653,
AL120854, AW068845, AI873731,
AI349614,
AI699857, AI282655, AI635461,
AL036802,
AI499463, AI590128, AI866002,
AI497733,
AI564719, AI475371, AI866887,
AW235035,
AI687376, AI620284, AL038605,
AA640779,
AA613907, AW080838, AI636456,
AI307466,
AI445432, AI625079, AI224992,
AI907070,
AI631107, AI969601, AI818683,
AI499393,
AL040243, AA572758, AI811863,
AW 148320, AI800453, AI800433,
AL036980,
AL036274, AL036759, AI285735,
AI920968,
AI800411, AI889203, AW302965,
AL119748,
AI349598, AI434281, AW166645,
AI889839,
AI597750, AI5979I8, AI282903,
AW132121,
AI690835, AI758437, AI610307,
AI934036,
AI469532, AI609592, AI583316,
AI580190,
AL120736, AI753683, AI687415,
AL040169,
AI919058, AI469811, AI366991,
AI446606,
AI680113, AL043326, AI340519,
AI874109,
AL038778, AI432229, AI281773,
AI952114,
AL048871, AI624859, AI866780,
AI610645,
AI269696, AL038779, AW074869,
AI475134,
AI671679, AI309401, AI348897,
AI343059,
AI696846, AI909666, AI539771,
AI624668,
AI620868, AI569616, AI539153,
AI568855,
AI345744, AL036240, AI440239,
AI499131,
AW301300, AI149592, AI628205,
AI570384,
AI687375, AW167776, AI25507I,
AI799199,
AI813914, AI862142, AI271786,
AW002342,
AI921379, AW085799, AI475947,
AI334902,
AI818206, AI636445, AI682841,
AI345111,
AI907061, AI804585, AA585422,
AI492540,
AL047041, AI307558, AL036260,
AI270055,
AI500659, AI349226, AW087445,
AI754897,
AI281762, AI580984, AA508692,
AW075351,
AI609580, AW168384, AI493248,
AI859733,
385
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI687362, AI802542, AA938383,
AI909662,
AW026882, AL042753, AI345860,
AL036247,
AI499512, AW129202, AL121014,
AI580240,
AI696398, AI439745, AI635942,
AI799305,
AW268768, AW118512, AW196141,
AI679764, AI445025, AL044207,
AA528491,
AW104724, AI610756, AL037137,
AW302992, AA528822, AW183130,
I48979,
AF113691, AL080060, 578214,
L31396,
L31397, AF090934, AF090943,
AF090900,
AL117457, AF118064, AF125949,
AF090901,
Y11587, AL133640, AL050393,
AL137527,
AF113013, AF113694, AF090903,
AF078844,
AF 113676, AF 104032, AF 118070,
I89947,
AL133016, AL110196, AL049938,
AL049452,
ALI1022I, AL133606, AJ242859,
568736,
A93016, AR059958, AL050146,
AL117460,
AF113690, AF113689, I89931,
AL050149,
X84990, AB019565, AF090896,
A08916,
AL050116, AL050108, AL122050,
U42766,
AFI06862, AL133075, A08913,
AL049466,
AF113677, AL049314, AL080137,
AL122093,
AF113019, AF017152, AL137283,
AL096744,
AL133093, AL133557, AJ000937,
AR011880,
AL050277, E03348, AL080124,
AF158248,
AL049430, Y16645, AL133080,
AF113699,
U91329, AL122121, AL133565,
I48978,
X63574, AL137557, AL137459,
AL122123,
E07361, Y11254, AF079765,
AF111851,
AF097996, AF091084, AL050138,
AF146568,
AL117394, AF125948, X82434,
AF177401,
AF017437, AL110225, AL117583,
I49625,
AJ238278, U00763, AL137550,
A65341,
E07108, AL133560, AL117585,
AL049464,
AL049382, S61953, A08910,
E02349,
AF067728, A08912, AL049300,
AL117435,
AL050024, AF091512, E05822,
X70685,
AC002467, I33392, AL122098,
A08909,
U72620, A58524, A58523, AF183393,
AL137538, A03736, 282022,
ALI37648,
AFI18094, A77033, A77035,
AL137463,
AL133113, AL122110, AF061943,
AC007390,
AL080127, AF087943, AL049283,
A12297,
AL137271, X72889, X96540,
I0332I, I09360,
U80742, AL096776, X65873,
U67958,
AC006371, X93495, AL022147,
U35846,
AC004690, I66342, I42402,
AL 110197,
AC004686, AC006336, X98834,
AL137521,
AL080159, AL035067, AR000496,
U39656,
E15569, I17767, Y09972, U95739,
AC007172,
AC004093, L13297, AL133072,
E08263,
E08264, AC007392, AF119337,
AC007298,
AF000145, AL133568, AF111112,
AL035587,
I26207, AL133104, AF106827,
U58996,
AF026124, AF185576, AC006112,
AL133077,
AR038969, AJ012755, AL137523,
AL137533,
L78810, AC002464, A93350,
AL137560,
M30514, AC004200, AL137556,
AL122049,
AF042090, and AL050172.
386
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HSSGK13 162 11380161 - 695 15 - AI290875, AI680938, AI290954,
709 AI809385,
AW090713, AI809382, AI656278,
AI290676,
AI655905, AI814637, AA629594,
AI990369,
AI954146, AI290667, AI963894,
AI653321,
AA777006, AW246438, AI004884,
AI914285,
AA868085, AA811734, C20609,
AA142969,
AI214540, T18947, AI122726,
N24152,
AA012878, AI872967, AA600184,
AA430289,
W92314, AA059252, AA019929,
AA020989,
T50739, AA665477, W26392,
221172,
W81609, AA150639, AA059218,
AA969737,
AI769298, W92301, AA580932,
AI824825,
X85617, X85621, AA015710,
AI694297,
AI990626, AA248247, AA328166,
AA412211,
AL049061, AA431706, AC008013,
AC006432, AC007040, and AC007880.
HTJND16 163 11377671 - 207815 - AA316097, AI160786, AL042373,
2092 AI583142,
AW338860, AA297776, AIS67676,
AA484892, AI370470, AI040051,
C06329,
AL044701, AI150934, AA070216,
AI890857,
AA676592, W96277, AA079260,
AI143653,
AW338021, AA441810, AA653291,
AC006581, 298946, AL109827,
AL109758,
AC007386, AL121603, 293023,
AL035413,
AC007263, AC004878, AL035420,
AL109984, AL133163, AB023051,
AC005288, AF196779, AC004386,
AC005484, AC000003, AC005104,
AL049759, AL031228, AP000512,
AC004876,
AC007011, AC005565, AC004771,
AC002468, D87012, AC007546,
AL022322,
AP000470, AB022537, AC004212,
AD000092, AC005519, 282214,
AB001523,
AC004832, AC006120, AL031602,
AP000047,
AC005014, 298200, AC005225,
AC007226,
AP000115, AL049569, AC006538,
AC003070,
AC005004, AL139054, AF196971,
AC005231,
AC009263, AC005015, AB023049,
AC005067, AC003689, AC007225,
AC005399, AL023553, AC006450,
293017,
AP000557, AC005598, AL050318,
AL049539,
AC002546, AL049636, AC002425,
AF053645,
AL031848, AL031670, AL109623,
AC006948,
AP000466, AB022785, AC006011,
AF031078,
AC005046, AC003976, AC004849,
AL022721, AP000252, AC005379,
AC006084,
' AF030876, AC005920, AC005089,
AC002476, AL022320, AC000387,
AL031255, U07562, AC020663,
AC005239,
AC005562, AC006480, AC002310,
AC006023, AC004920, AL022334,
AC005200, AC006312, AC005212,
AC002316, AC004150, AL096701,
AC004587, AC005768, AC003688,
AC007193, AP000030, AP000212,
AP000134,
AC005363, AF111169, AL035587,
AC004777,
AC006071, AC007388, AF130343,
AL034549,
AL024498, AC004682, AF003626,
AC004025,
AF121781, 285996, AC002551,
AC012627,
387
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC005520, AC000068, AJ246003,
AC005261,
AL021393, AP000065, AP000502,
AL050307,
AL035684, AC004409, 282178,
AC006211,
AC004882, 297630, AC005291,
AL031594,
AC002997, AC006213, AC006160,
AL022396, AC005058, AC005899,
AC006441, AL031291, AL049713,
AP000555,
AL035667, 298047, AC002300,
L09706,
AF111168, AD000812, AP000359,
U62317,
299716, AF196969, AC002314,
AL035685,
299943, AC002418, AP000355,
AL035249,
AP000505, AC006139, AL035423,
AC005829,
AL049776, AC006166, AL008735,
AL035415,
AC005839, AC005589, AL008719,
AC003695, AC005821, AC002429,
AC007981, APOOOI 13, and
AP000045.
HEQAP17 164 9493581 - 807 15 - AI131555, AI769466, AA215577,
821 AW190975,
AA258335, AA258499, AL044652,
S63848,
Y17793, and A49045.
HNTOA59 165 I2235I31 - 2813 IS - W18181, AI335263, W60570,
2827 AW305247,
AI949857, AI769932, AI376764,
AI018234,
AI143581, W60661, AI051990,
AA923566,
AA873841, W68384, H11953,
AI754510,
H30442, AI190109, AI613113,
AA456821,
W68500, 816198, 860608, 816196,
H18573,
820002, H30393, H11954, 844819,
860554,
AI961171, H06599, H18466,
AI498856,
AI949054, W32128, AA374468,
H30392,
H30441, 816000, 816197, AA569932,
AA767140, 241415, H88480,
245096,
F08421, AI929237, N54033,
AA127201,
AA662224, AA319784, T16809,
AA127202,
T03447, AA224064, 240835,
AA095915, and
AI651893.
HE8AZ89 166 10079291 - 703 15 - AA332152, AA356092, F07677,
717 AA204763,
N89342, AA309660, A98668,
and AL033527.
HNGE079 167 11263181 - 1545 15 - AI024236, and AW403530.
1559
HDPIX67 168 11822631 - 2932 15 - AF147773, AF152898, AI708697,
2946 N51342,
AA825888, AI292226, AI288960,
N39421,
AA975060, AI261689, AW291891,
N48537,
AI695627, AA406030, AI699867,
AA406029,
H26638, AL046205, AA669840,
AL046409,
AI284640, AW274346, AA508359,
AW069510, AW303196, AI963720,
AI431303, AW079792, AW301350,
AA490183, AI270117, AI583283,
AW193265,
AW274349, AI799642, AA468244,
AI370878,
AI654525, AA584195, AA806796,
AA846876,
AL138455, AI434695, AA587604,
AI972203,
AW338086, AA613203, AL134972,
AI537955, AA491814, AW438643,
AW276827, AW265385, AA580808,
AA577906, AI350211, AA503600,
AI821271,
AA584167, AL037683, AA623002,
AI370074,
AA618452, AW273218, AI375710,
AA503473, AI382614, AI613280,
AI754955,
AI801591, AI499938, AW021583,
AA467820,
AA977743, F1789I, AI471481,
AI053672,
AA713891, AI061I43, AW073470,
388
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA664581, AI732120, AI688846,
AL121235,
AI610159, AA720702, AW022379,
AA453558, AI744995, AA653618,
AW072587, AI281881, AA613227,
AI919029,
AI312309, AA569387, AA551503,
AW440497, AA599920, AW193432,
AW075511, AA847952, AA502155,
AI860013, AI708125, AA488746,
AA613232,
AA594145, AI564185, ALI 19984,
AA679672,
AW162049, AI370094, AI633025,
AI929531,
AA908468, AI339850, AI434311,
AW050498,
AW103758, AI687260, AL040921,
AA664015, AI368745, AW327868,
AI457397,
AI754658, AI379719, AI423625,
AA507824,
AA521323, AA351056, AI341664,
AI281468,
AL119691, AI345654, AI192631,
AI366464,
AA525824, H51714, AA713815,
W79504,
AA468131, AI061334, AI085719,
AA601499,
AA367986, AI619997, AA177061,
AW079135, AA478355, AI133164,
AL042753, AA335134, AI962050,
AA984708,
AI301700, AL044940, AA934680,
AI298710,
AA508034, AA652764, AA533725,
AA658362, C75026, AL039958,
AW148792,
AI143242, AA579063, AI567674,
AW270382,
AI371070, AA610491, AI674873,
AA523843,
AI149478, C05986, AI289067,
AL041146,
AA665199, AL046898, AW270270,
AW192154, AI355224, AI568678,
AI635279,
AI754253, AW276435, AI133297,
AW029038, AA521399, AA634889,
AA346458, F36273, AA502104,
AI475569,
AW088846, AA572713, AI814735,
AA581903, N29948, AI148277,
AA491831,
AW261871, AA469451, AI246119,
AI687343,
AA493708, AI537506, AI610920,
AI251436,
AI110770, AA610493, AA714453,
888888,
AI355206, AW440545, AA483223,
AI754336,
AC008372, AC004025, AC002365,
AFI30248, AC010197, AC005145,
AC005532, AC006484, AP000042,
AE000660,
AC009802, AL121577, AC004519,
AF067844,
AC010849, U82672, AL033397,
AC000126,
AL133321, AL035604, AC006353,
AC005902, AC004072, AC002449,
AP000101, AC007157, AL008633,
AL096816,
AL034562, AC004887, AC004787,
AC004448, AC006013, AP000952,
AL121757,
AC003003, AL078477, AL133445,
282205,
AC005881, AL132766, AC005279,
AC008149, AC004843, AF064866,
AC005913, AC012083, AL008715,
AL034408, AL035446, AL133249,
AL135747,
AC006965, AC007743, 297196,
AL080276,
AL034399, AC007968, AC005739,
AP000085,
AL049550, AP000264, AC006045,
AF042090,
AC006512, AL023280, AC004551,
AL078463, 286090, AL035462,
AC005251,
AF003528, AC002090, AC006578,
389
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC007386, AC007538, AF165142,
283846,
AC004020, AF088219, AC003051,
297195,
AL035251, AC004743, AL035070,
AC008085, AF165147, AL035457,
AC005146,
AC006222, AC006445, AC002377,
AC005962, AC006925, AC005062,
AP001068, AL132800, AC004589,
AC004106,
AL096791, AC004864, AJ011930,
AC006327,
AL110503, AC004664, U95743,
AL034395,
AC008014, AL009175, U80017,
AF043945,
298257, AL122020, AC005728,
AC004963,
AF060568, U91319, AC002461,
AC005534,
AL133392, AC005295, AP000124,
AL021391,
AC004862, AC007488, 295118,
AC005876,
AP001067, AL078581, AL121748,
AP000344,
AP000014, AC002538, 275892,
AC008125,
297632, AC006952, AL132994,
AC007842,
AF011889, AP000031, AL049554,
AL109616,
AL022163, AF109076, AC005220,
AC005993,
AP000493, AC007437, AC002529,
AL020990,
AP000432, AL049690, AP000330,
AL121595,
AP000964, AL035695, AC002349,
AC004508,
AL022161, AL034548, AC006459,
AC004552, AP000210, AP000132,
AC007115,
AC007243, AC004744, AL031368,
AL109653, AC004382, AL080316,
AL022164,
AC002127, AC005598, AL031656,
AP000459,
AC004647, AC006515, AC007221,
AP000966, AC010200, AL133238,
AP000107,
AP000039, AL049697, AP000133,
AP000211,
AL031664, 299943, AC004984,
AC004780,
AC004486, 282194, AC005209,
AC006360,
AL009173, AC006210, AL021408,
AP000431,
AC006016, AC005274, AP000472,
AL031346,
AC003103, AC010170, AB020862,
AC003961, AL121578, AC013417,
AC006454, AL008627, AF200465,
AC004946,
AC005011, AL024506, AC007751,
AC006296, AC005599, AC005815,
AC008040, AC005548, 283826,
AL035451,
AC001234, AF205588, AC006960,
AC004533, AC004820, AL021920,
AC005070, AP000280, AL133500,
AC005031,
AC007688, AF123462, AC004925,
AC006063, AC009275, AL031653,
AF001549,
AC000117, and AL031432.
HWLLBl 169 9548491 - 731 15 - AI745636, and AA102414.
1 745
HNTEF53 170 9548521 - 234215 - AA557324, AI655577, AI696732,
2356 AI923200,
AA863360, AW262723, AI697332,
AW275990, AI436648, AW276183,
856515,
AI362521, 853456, 853457,
D62878,
AA337301, AA652746, AW264444,
856123,
AA319338, D79346, D79250,
N56346,
AA886832, and AL138223.
HNTND64 171 9548711 - 392 15 - AC025090, and AC025090.
406
HFPFA83 172 9556141 - 723 15 - 014389, 015076, D59467, D58283,
737 D50979,
D80522, D80164, D80166, D80195,
D80043,
D80227, D81030, D59275, D59502,
D80188,
D59859, D80022, 014331, D51423,
D59619,
390
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
D80210, D51799, D80391, D80240,
D80253,
D80038, D80269, D59787, D80193,
D59610,
D80212, D80196, D80219, D81026,
D59927,
D57483, D80378, AW177440,
D80366,
D80251, AA305409, AA305578,
D59889,
D50995, D80024, D80241, D51022,
D80045,
C14429, D51060, C75259, T03269,
AW178893, AW179328, AA514188,
AW378532, D80248, C14014,
AW377671,
D51250, AW369651, AW178762,
AW178775,
AW177501, D80134, AW177511,
AA514186,
D80133, AW176467, D58253,
AW360811,
AW352117, C05695, AW375405,
AW352158,
D80268, AI910186, D80132,
AW366296,
AW178906, AW360844, AW360817,
AW375406, AW378534, AW179332,
AW377672, AW179023, AW178905,
D80302,
D59627, AI905856, AW378540,
AW352171,
D80258, D80439, AW377676,
AW352170,
AW177731, AW178907, AW179019,
AW 179024, D59373, D80247,
AW 177505,
AW179020, AW360841, AW178909,
AW 177456, AW 179329, AW 178980,
AW177733, AW378528, AW178908,
AW178754, AW179018, AW352174,
221582,
AW360834, D51103, AW179004,
AW179012,
C06015, AW178914, AW378525,
AW367967,
D80157, AW 177722, D51759,
AW 177728,
AW179009, AA285331, AW178774,
AW178911, D51097, AW378543,
AW352163,
D58101, D80064, D58246, D80014,
D59503,
AW178983, AW352120, AW178781,
T48593,
AI535850, AW177723, T11417,
D59653;
AA809122, AW177508, D45260,
D59317,
C14975, AW378533, AW367950,
F13647,
D81111, H67854, C03092, C14227,
H67866,
AI557774, AI525923, AW177497,
T02974,
AI557751, AW178986, T03116,
C14298,
D45273, D52291, AW177734,
D59474,
AI525917, AI525227, D59695,
D60010,
C14973, AI535961, C14344,
C14407,
AI535686, C14957, D51221,
D59551,
AI525920, AA514184, AI525242,
D60214,
T03048, 614046, AI525912,
AI525235,
C16955, AI525925, AI525222,
D80168,
AW378542, AW378539, AI525215,
AI525237, C05763, 233452,
AI525928,
AW360855, T02868, D51213,
D31458,
H67858, AR018138, AJ132110,
A84916,
A62300, A62298, AR008278,
AF058696,
AB028859, X67155, Y17188,
D26022,
A25909, A67220, D89785,~A78862,
D34614,
D88547, I82448, Y12724, X82626,
AR025207,
AR016808, A82595, AR060385,
A94995,
AB002449, AR008443, AB012117,150126,
I50132, I50128, I50133, AR066488,
AR016514, AR060138, A45456,
A26615,
AR052274, A85396, AR066482,
A44171,
A85477, I19525, A86792, Y09669,
A43192,
391
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
A43190, AR038669, AR066490,
U87250,
AR066487, X93549, I14842,
A30438, I18367,
D88507, AR054175, D50010,
Y17187,
A63261, AR008277, AR008281,
AR008408,
AR062872, A70867, AR016691,
AR016690,
U46128, D13509, I79511, A64136,
A68321,
AR060133, X68127, AF135125,
U79457,
AF123263, AB023656, AR032065,
AB033111, X93535, and AR008382.
HFIZB56 173 9556181 - 666 15 - AA298425.
680
HFPHR82 174 9575281 - 157915 - AA913364, AW027373, AW305275,
1593
AI799031, AW117480, AA588138,
AA775450, AW190848, AA411334,
AA866178, W61038, AA411335,
AA775769,
AA769134, AA075643, N30274,
AI493881,
. AA627544, AI147666, AA075644,
AA614747,
N30309, AA812101, AI025647,
AW339918,
AI140386, N94919, AI138196,
AA868924,
AI143201, AA284960, AI347094,
AI343592,
AI128292, AI017993, AI492556,
N41996,
N20511, N42630, AI933338,
AI554835,
W72001, W69402, AI679099,
AA040263,
T32745, AA872581, N29505,
AI268560,
AI354734, F28362, AI017992,
AA719956,
AA448442, AI679673, AA863176,
AA444022,
AI142803, AA732322, AA993672,
AI624135,
AI304774, W44314, W37097,
AI475118,
AI004213, W65308, AA846235,
AA448307,
AW274816, N25416, AI285067,
D79265,
W44778, AA305351, AA682603,
AA285117,
AI186604, AI149185, AI339799,
AI872626,
AA557809, AA444000, AI344717,
AI128110,
AA922743, AA996037, N56641,
H13966,
AA515842, F37123, AA732278,
W65338,
W76570, AA989130, AI239957,
821057,
AA721150, AI580506, 896887,
N26843,
AA034909, W45686, F09166,
H12989,
W19542, W69363, N57447, 896888,
C04314,
AW183468, H87003, AI719584,
AI685763,
824370, T35889, AA081676,
T34115,
N40568, AA010732, AW089136,
AW023063,
N63592, T35834, AA913531,
242311,
F11505, H05630, AA505347,
T35841,
T30076, AI366940, T30517,
H27007, 242248,
F09167, H87002, AA721261,
W56871,
T36163, AA040400, W19619,
846237,
AA863208, AA649338, F34780,
T35871,
H13965, AA913094, T35833,
AA034976,
AI274646, AA890331, N63619,
AA082031,
F05477, AA603299, AA322616,
AA603386,
827044, 238484, AI564372,
F01840, 827043,
827029, AI859366, 827028,
AA748381,
F01739, AA355325, H53598,
AI859362,
N46608, AA339209, and AF190797.
HBCBT19 175 9599531 - 758 15 - W58728, AW194384, AI921843,
772 AA131986,
W27452, AA861776, AW025219,
AA366467,
AA969204, AI077983, AI688167,
AA805925,
AI939498, T82046, AA026664,
AI627470,
871811, AW316534, AI189664,
860094,
392
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA007217, 853357, AA335794,
AI401269,
AI024367, AA131681, AA505874,
AI200318,
871771, W24578, AA026712,
AI676036,
AA806045, AI299373, AI890667,
AW118903,
H29874, N92383, H92161, AI267768,
AW075217, AA918168, AI885357,
AW372475, AW172330, AA844743,
AI149118, AI453474, AI357518,
and
AI262961.
HMCFA91 176 9599541 - 107315 - AW194384, AI921843, AW025219,
1087
AI024367, AI688167, AA861776,
AI189664,
AI627470, AW316534, AI200318,
AA969204,
AA505874, AA805925, AI077983,
AI401269,
W58728, AA026664, AI299373,
AW075217,
AI676036, AI890667, AW118903,
AI937114,
AA573507, AA131681, AI453474,
AW372475, 871771, 853357,
860094,
AI149118, AA844743, AA918168,
H29874,
AA007217, H92161, AI262961,
AA131986,
T82046, AA806045, N92383,
AA335794,
AI024365, AI939498, W27452,
AA635601,
AA766069, AW243229, AW 166051,
AA366467, AI267768, AI572256,
H92160,
and 871811.
HTEIB14 177 11280441 - 739 15 - AI126171, AW172978, AI802445,
753 AI811298,
AI624106, AI807074, AI635206,
W96514,
AI190433, AI810701, AI271523,
H43143,
AI911113, AI803788, AI566934,
AI187824,
AA644026, AI869010, AI015017,
855050,
AL043767, AA043579, AL045986,
W96481,
and AA568260.
HEAAA42 178 11280091 - 859 15 - AI126171, AW172978, AI802445,
873 AI811298,
AI624106, AI807074, AI635206,
AI190433,
W96514, AI810701, AL043767,
AI271523,
H43143, AI911113, AI803788,
AI187824,
AI566934, AA644026, AI869010,
AI015017,
855050, AA043579, AL045986,
W96481, and
AA568260.
HTTFZ40 179 12191721 - 429 15 - AL049061, AA150639, W92301,
443 W81514,
AA431706, AW246438, AA248247,
T50897,
AA059252, AI214540, AC008013,
AC006432,
AF176315, AC008010, and AF042089.
HSODC08 180 11894931 - 143215 - AW007193, N6481 l, AA452032,
1446 AW339062,
AW340188, AA401432, AI568619,
AW169936, AI680519, AI271472,
AA131132,
AA400000, AA885882, AI338757,
H94846,
AA749092, AA406402; AA771971,
AI250802,
AI499729, W95739, AA975465,
AI147856,
AI521267, W95717, AA284462,
AA902995,
AI969258, AI143369, AA668710,
AA772776,
AA410424, AI278748, AA465528,
AI09442I,
AI280111, AI031849, AI022538,
H94904,
AA448926, AA932880, AA939066,
N50516,
AI026050, AA888455, W46552,
N50572,
AA448961, AA908448, AA970161,
AW304057, N63986, AW004817,
AA383538,
AW192281, AI185874, AA131080,
AI376899,
AW391424, AA812994, AA383509,
T89723,
Rl 1866, AI139250, T77066,
AI088806,
393
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI129789, AW055052, AI125975,
AI819247,
T23688, N20360, AW241784,
854185,
AI369764, F04415, AA652033,
AA235367,
239152, AA227964, AI453662,
AA287030,
AA449688, AL041309, TI9082,
H69643,
AA905527, AA327543, 882840,
863558,
230290, H70490, T77372, N75661,
841336,
AA483304, 863513, T03899,
F03826,
AA628264, 817743, T36034,
882841,
242109, AW084208, F01646,
818488,
AA449436, AI653940, AA758342,
AA445917,
244861, AA326881, AA578092,
W46551,
N79664, T36046, 245556, D58699,
854184,
AA227800, AW189605, F08360,
AA032157,
AA452066, AA032158, F04583,
N89197,
AA937717, AA327792, D11979,
AA25I236,
AC005332, and AW572515.
HAHHE43 181 11822551 - 253315 - 2547AA442414, AL037261, AW070401,
AI457525, AI016211, AI433014,
AI240432,
C21505, AW382682, AA587446,
AA848047,
AW074687, N38806, AI285709,
AI809829,
AA551399, AA226173, AC006441,
AC005015, U91323, L78833,
298200,
AC004531, AC007225, AC005911,
AC002302, AL008718, AC005666,
AL049761, AC002420, AL031685,
AF134726,
AC004966, AL117258, AL031311,
AC005088, AL096791, AL109758,
AL023807,
285987, AL009172, AC006014,
AC005037,
AC004106, AC004883, AC007277,
AC004216, AC005081, 293241,
AC006270,
AL139054, AC007676, U96629,
AF001549,
AC005089, AL031670, U91321,
AC002365,
AF111168, AC004893, AC005049,
AC003982, AC005488, AF196779,
284466,
AL050307, AC002565, AC005531,
AC004797, AP000553, AC005899,
AD000092, AC003663, AL031680,
AC005104, AC005071, AL031276,
AL022237, AL034549, AC004491,
AL080243,
293017, AC004841, AC005011,
AC005620,
AC005328, AC004813, AC005484,
AC007686, AC006026, AF030453,
AC005102, U15422, AC005803,
AL121655,
AF030876, AC005722, AC005736,
AP000501,
AC002563, AC007216, AC008072,
AF109907, AC003070, AF047825,
AC007993,
AC007298, ALI33163, AC007283,
AC007773, 298941, 299127,
AC006480,
AC003029, AF053356, AP000194,
AC004834,
AF001548, AC005972, L78810,
AL109984,
AC002059, AL109798, AL049874,
283844,
AC002550, AC007371, AC006121,
AC000026, AP000502, AC006285,
AL049779,
A$003151, AC005409, AL024498,
AL132712, AC003043, AC005180,
AP000692,
AC002350, AC005067, AC004253,
and
AF001552,
HWMES65 182 ~ 11263471 - 983 15 - 997 AW001264, AW207107, AI816763,
394
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW182674, and AC006237.'
HE8NI24 183 9712961 - 737 15 - 751 AA883367, AA332611, AA732890,
AI283442,
AI673342, AI631153, AI200800,
AI910962,
T11417, D80258, D59503, D80014,
D81111,
C14227, D80064, AI557751,
D58246, C06015,
AA514184, AI535959, AW178893,
AW178907, AW375405, AW177440,
AI535686, AW360834, AW178908,
AW360811, D80314, AA809122,
D80251,
D80253, C03092, D80247, D80043,
AA285331, AW176467, C14389,
AW179328,
T48593, AW375406, D80439,
AW378534,
AW179332, D58283, AW377672,
AW179023,
AW178905, D59859, D80022,
C14331,
D80166, AW177731, D80195,
AA305578,
D80193, D59927, T03269, D59467,
D51423,
D59619, AW378528, D80210,
AW178906,
D51799, D80391, D80164, D59275,
AW178762, D80240, D80038,
AW179019,
D59787, D80227, AW378533,
D59502,
AA305409, AW378532, F13647,
D45260,
AW178914, AW378542, AW360855,
AW377676, I50126, I50132,
I50128, I50133,
AF123263, A70867, D88547,
AR062872,
AR066488, AR016514, A62300,
D50010,
X82626, AR066487, Y17187,
AR060138,
A84916, A45456, A67220, D89785,
A62298,
Y09669, Y17188, AB028859,
A82595,
A78862, D34614, A94995, D26022,
AR060385, A30438, AJ132110,
AR018138,
A26615, AR052274, A43192,
AR008278,
X67155, Y12724, A63261, A43190,
AR038669, AF058696, A25909,
X68127,
AR008443, AB002449, AR025207,
AR016691, AR016690, and U46128.
HI3ATR09184 11263631 - 927 15 - 941 AA641818, AW409775, AI539153,
AW265004, AI349958, AW023338,
AI538342, AI472536, AI567582,
AI590118,
AI570966, AA455772, AA835966,
AW085786, AI677797, AW088899,
AI365256, AI336754, AI538270,
AI491710,
AI559872, AW162194, 836271,
AA999906,
AI866082, AI472566, AI611743,
AI824748,
AI865320, AW163834, AI249946,
AL038529,
AI669639, AI282504, AI446124,
AI348914,
AW022636, AI670009, AI251221,
AL043345,
AI862144, AW172723, AI828574,
AI633061,
AI095113, AI280661, AI918554,
AW130930,
AI434242, AI752007, AI915295,
AI922561,
AI491852, AL046463, AI933785,
AW243637,
AW019985, AI889147, AL040243,
AI866770,
AL079794, AI805638, AW151847,
AI559863,
N63128, AW 168031, AW403717,
AI620093,
AI950692, AI569589, AI874243,
N99092,
AI830187, AI244380, AI886594,
AW051059,
AA693347, AW151729, AI571945,
AI889306,
AW151948, AW028840, AI952302,
AI569294, AW004886, AI963062,
AI539111,
AA658033, AI648567, AW089006,
AI281867,
395
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI452993, AW149876, AI697149,
AI799195,
AW130829, AI499161, AW161579,
AI624529, AL038575, AI921176,
AI539771,
AL049053, AW188438, AI916419,
AI873638,
AI242248, AW 193467, AI866608,
AI567802,
AI34S608, AW073898, AI636619,
AI345415,
AI34S688, AL036638, AI249877,
AL135024,
AW168503, AI288285, AW131999,
AI811811, AL048323, AI690748,
AI470293,
AI697207, AI250627, AI582558,
AL048340,
AI633477, AI537617, AW084097,
AW194185, AI690813, AI923871,
AI659475,
AI698401, AI802240, AL036631,
AI582912,
AI453382, AI345471, AW059713,
AA579232,
AI440210, AI22S004, AW 151979,
AW087203, AA464646, AL038864,
AI418970, AW152000, AI334445,
AI805688,
N71180, AW129271, AW07S6S7,
AI277008,
AI648408, AI366549, AI636719,
AI289310,
AI586931, N75771, AI553669,
AL040694,
H89138, AI951373, AI623682,
AIS64259,
AI267162, AW082623, AI932949,
AI865297,
AI684013, AI499986, AIS37677,
AW263804,
AI744485, AI56735I, AW083804,
AA830821,
AI696626, AI289542, AA811736,
AL040586,
AI473528, AI589993, AI690536,
AI921746,
AW073697, AI310575, AW022494,
AI345677, AA494167, AI569616,
840432,
AW021091, AI886055, AA568405,
AI4S3767,
AW162189, AW007300, W46547,
AI923989,
AW169291, AW117919, AI340533,
AI832457, AI955945, AI521095,
AI114703,
AI859644, AW130863, AI874151,
AI888621,
AI357599, AL040241, AI890507,
AI352573,
AW079334, AI886062, AW301409,
AW026630, AL038956, AW151136,
AA806719, AI419440, AI684279,
AI589428,
AI540674, AI868163, AI561356,
AL079740,
AI636788, AI829495, AI446373,
AIS00523,
F26535, AW088605, AI349933,
AI812080,
AI950664, AI251830, AL041150,
AI8S9464,
AI680326, AW082600, AI680066,
AI473451,
AL118512, I48978, AL110222,
AL133081,
AF090901, AL133624, AL137538,
AL117460,
AL122098, 579832, AF022363,
X06146,
A18777, AF118094, AF153205,
U00686,
AF040751, AF090886, AF061573,
E04233,
A08916, 577771, AJ005690,
AF113013,
X98834, I89947, AL133645,
I48979, A08913,
AL110218, I89931, A08912,
A08910,
AL137300, AL133S60, AF078844,
I49625,
AF114170, A08909, AF158248,
297214,
AR038854, AF090943, A08908,
AL080158,
576508, I00734, I89934, AF113677,
X87582,
E01812, U42031, AF12S949,
E00617, E00717,
E00778, AL137276, X57961,
U78525,
AF106862, AF000145, AL050116,
Y08769,
AB019565, AL049996, AF120268,
AR0599S8,
U96683, U87620, I09499, A12297,
AL096751,
396
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AJ006417, AL137292, AL117648,
AF065135,
AL050172, AL110296; AF094480,
AF039138,
AF039137, AL122123, I22272,
AF067790,
AJ001838, U77594, AR000496,
U39656,
J05032, I30339, I30334, AL080137,
AF032666, AF067728, AF115392,
M86826,
AL117457, AL050149, AF162270,
I89944,
AL122110, A86558, X79812,
U92068,
. A77033, A77035, U35146, AL110158,
A07647, AL137256, I32738,
AF137367,
U42766, AL117432, D83989,
A08907,
X66862, 272491, X54971, U72620,
A57389,
AF111112, 575997, AF113694,
AL133104,
AF113689, AL133558, X62580,
AL080154,
AL110197, AL137459, AL133016,
AL137658,
AB029065, A15345, X81464,
AR06875I,
A21103, AL080060, AL137556,
E03348,
563521, A65340, Y11587, AF215669,
E03349,
AL117626, AF1511.09, L30117,
AF031147,
AF159615, X72387, AL137574,
AL110221,
569510, M27260, AL137712,
AF125948,
AL133077, AL117440, AF016271,
U80742,
AL050155, U72621, AL050393,
X93495,
AF102578, AL137665, AL050170,
X72889,
AF113691, D55641, AF119337,
AF036941,
AL049339, Y16645, U95114,
AF132676,
X80340, AF061836, X52128,
X84990,
X55446, AL133557, E06743,
AF000301,
U66274, AJ003118, AL050108,
AL137660,
AL133014, AL117629, AL137294,
X53587,
U88966, AF012536, AF113690,
AF028823,
AL117585, AL049460, AL110196,
AL137640,
AF069506, AL122106, AL117583,
AF176651,
AF114818, AL137711, D83032,
AF205861,
I66342, AL137533, AL137547,
AF180525,
AF113699, AL133619, E01614,
E13364,
U00763, E15582, E12747, AF026816,
AL137429, AL133640, U90884,
AF111851,
AJ238278, AF026124, AL080127,
AL080148,
AL137527, AL133665, AL133565,
A03736,
AC002467, AC004686, ALI37539,
AL137463, Y16258, AL050277,
Y16257,
E02756, Y16256, L13297, E02253,
AL080159,
AL049382, I42402, AL117416,
and A90832.
HNTAR65 185 12266631 - 7425 15 - AI049973, AI074162, AI129798,
7439 W72413,
AI742408, AI271445, AA421324,
AA628934,
AI809207, AI580138, AI374848,
AI375883,
AA007356, AA677217, AI374762,
AI367657,
AA205650, AI304678, AA699617,
AL135602,
AI751304, AA677283, AA007357,
AI051577,
AI703389, AI373751, AA779885,
AI912137,
AW338397, W76492, AA253383,
AI801494,
AA253409, AA418327, AA650047,
AA872682, AI572030, AA659498,
AI399798,
AA112559, AI521517, AI266089,
AI572944,
H21758, H08513, H39571, AI220937,
AI244126, H24807, AA418276,
AA354918,
H14450, H22230, AI751305,
H39576,
AA331568, AA421429, N26115,
H21951,
397
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA341091, AA341614, AI418670,
AI986092,
AI093927, AA368627, AA629154,
AI915747,
AI143110, AI363958, AI680873,
AA599582,
H25154, 242644, H52517, AA907318,
F02146, AI872553, AA095608,
H08789,
AA342530, AI638676, AL119319,
847419,
AW392670, C02194, U46347,
AL119399,
AL119457, AL119324, AL043003,
AL119484,
AL119439, AW384394, AW363220,
AL042544, AL119355, AL134519,
AL119497,
U46351, AL119443, U46350,
AL119391,
299396, AW372827, AL119363,
U46349,
AL119522, U46341, AL119444,
AL119483,
AL134132, AL134530, AL042551,
AL119396,
AL119341, AL134531, AL037205,
AL119401,
ALI34527, AL134528, AL043147,
U46346,
AL119335, AL119418, AL134533,
AL042542,
AL119496, AL134538, U46345,
AL042614,
AL043019, AL042989, AL042450,
AL042965,
AL042975, AL043029, AI142134,
AL042984,
AL119464, AB026436, AR060234,
AR066494, AR054110, A81671,
and
AR069079.
HYABP53 186 11098201 - 1436 15 - AW295244, AW383680, AA291031,
1450
AA836103, AA825935, AW383670,
AW451843, AW383673, AA290625,
AI377702, AI347054, AL119324,
AL134524,
AL119457, AI431323, AL119399,
AW392670,
AI432666, AL042544, AI432644,
AI623302,
AI431307, AI431316, AI431238,
AI431230,
U46347, AW081103, AI432677,
AI432653,
AI432654, AI432650, AI431353,
AI431328,
AI431235, AI431312, AI431321,
AI431315,
AI4326S5, AI431310, AI431246,
AI431231,
AI431257, AL119443, AI431347,
AL043003,
AL119484, AI432657, AI431247,
AI431354,
AL042729, AI431350, AL119439,
AL042533,
AI431318, AW384394, AW363220,
AL042931, AW372827, AI791349,
AW129223, AI432661, AL134153,
AL042655,
AL042842, AL042508, AL042420,
AL042853,
AL119319, AL119418, AI431314,
AI863305,
AL043166, AL042832, AL047611,
U46351,
AL045327, U46350, AL135012,
AI492510,
AI492519, AL119391, AI432643,
299396,
AL042802, AI432675, AL042741,
AL119497,
AW128884, AW128900, AI431337,
AL119363, AL042787, AL119355,
AI432651,
AI432647, U46349, AL042515,
AL119522,
U46341, AL119444, AL119483,
AI142134,
AL043295, AW084068, AL134132,
AL119396, AI432674, AL134530,
AL134519,
AL119341, AI431330, AL134531,
AL037205,
AL119401, AL134527, AL134528,
AI431308,
AL043147, AI431243, U46346,
AL119335,
AL119464, AL043091, AI431248,
AI432649,
AL134S33, AI432672, AL040207,
AL042542,
AL119496, AL042488, AI432665,
AL134538,
U46344, U46345, AL045328,
AL043089,
398
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI431241, AI284508, AL046356,
AL043321,
AI561182, AL042614, AF019249,
AR066494,
AB026436, Y17793, AR060234,
AL133074,
AL133053, AL133049, AL133076,
AR054110,
A81671, AL133068, AL122101,
and
AR069079.
HSXBV89 187 10270211 - 223315 - 299410, AW373793, AA553665,
2247 AI190674,
AI366341, AI184600, AW004692,
H10539,
AA482462, 845646, AI521134,
AA973962,
842556, AA720003, H11452,
AA211375,
822747, AW009222, AA417872,
AA632195,
W39346, 852677, 861178, AA720022,
861892, T80548, 820364, H46470,
F07364,
886859, 855930, 241453, AI360146,
887776,
H08592, AA483558, W38313,
855720,
843749, T30657, AA426408,
H95699,
AA363950, 818352, 815260,
818538,
887830, F05821, 887766, 810214,
890750,
T15918, F03602, T34747, H95698,
W84692,
887845, T78493, F08462, T16643,
AA210976,
813935, 825677, H50912, AA349344,
AI302317, 299411, F07877,
AA643729,
852724, 843750, AA522619,
F02068,
843495, 841527, H52035, AI092517,
AI291295, AI570476, AI951902,
AI906668,
AI906666, H38986, AI553790,
AW268395,
AI312547, AW450243, AI681390,
AI344432,
AI343814, N44903, W84640,
AA614791,
AJ245820, AJ245821, AJ245822,
and
AF 131749.
HPTZB93 188 9718421 - 836 15 - AI279486, AW206040, AW138281,
850
AI817720, AW205987, AW206016,
AI694554, AA862263, AI860959,
AI298729,
AI299747, AI216051, AW340960,
AI703067,
AI885693, AW341220, AI681397,
AI802146,
AI066735, AA923300, AI127856,
AI279331,
AI298540, AI912139, AI630777,
AW140104,
AI002211, AI634502, AI268259,
AI796940,
AI129532, AI299414, AI914342,
AI692842,
AA938376, AW137441, AW207254,
AI216530, AI268955, AI459037,
AW136174,
AI693815, AI299132, AI912208,
AI301061,
AI299900, AI298698, AI702631,
AI298009,
AI871768, AI810454, AI689870,
AW016202,
AI458645, AI222004, AI689871,
AW102711,
AI702711, AI689859, AI804311,
AI732920,
AI732919, AA995350, N68345,
AI351290,
AA825171, AA962534, AI476744,
AA878309,
AA974790, AA934499, AA528135,
AI702851,
N94016, AI187311, AW003096,
AI670694,
AI223259, AW139377, AA916697,
AI791238,
AA829735, AA885627, AI791237,
AA910380,
AW003320, AA911255, AA987456,
AW024083, AA971615, AA916296,
AA953807, and AA128824.
HTSHM38 189 11306481 - 231615 - AI907172, AL043009, AI679782,
2330 AI499938,
AW378532, AL046409, AI284640,
AI334443,
AA595782, AL119691, AI431303,
AW303196, AW274349, AA587604,
399
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW407578, AW301350, AW193265,
AI270117, AI754658, AI350211,
AA490183,
AI110770, AL138455, AI613280,
AA631507,
AI341664, AI963720, AI537506,
AW276827,
AI289067, AW103758, AW338086,
AI708009, AW419262, AA470969,
AI133164,
AI085719, AW088202, AI375710,
AA488746,
AA613227, F36273, AL138265,
AW083364,
AW083402, AW193432, AA610491,
AW410400, AI688846, AL041690,
AW438643, AW302013, AA649642,
AI358571, AI801591, AI053672,
AI471481,
AI345654, AI814735, AI539563,
AI619997,
AI963263, AL079812, AL041146,
AI744995,
AI341548, AI281881, AI379719,
AL120269,
AI061334, AL038799, AI564185,
AI371070,
AI358343, AW406162, AI345157,
AI653636,
AI830390, AW238278, AI821271,
AW162049, AI929531, AW247819,
AW408717, AI761471, AL037683,
AA164251, AA583955, AA491814,
AI281697,
AI610920, AI799642, AI669453,
AI434695,
AW276435, AI919265, AI889781,
AI358501,
AA577906, AL042753, AI151261,
AW304584, AI718446, AW029038,
AI568678, AI962050, AA177061,
AI469172,
AI745151, AA347927, AI286356,
AL038705,
AA290878, AA652057, AI339850,
AW188484, AW023672, F32808,
AA584581,
AL042420, AA806796, AI305766,
AA226153,
AW339568, AL119810, AI340453,
AW261871, AA623002, AI144055,
AI890348,
AI567674, AI282832, AI590958,
AA482768,
AI610159, AL044940, AA513141,
AI561060,
AI537955, AI587583, AI587565,
AW276817,
AI886629, AA347930, AW088846,
AI709365,
AL135405, AI344844, AI370074,
AA587256,
AA621858, AI499181, AA526787,
AI345681,
AI345675, AW148792, AI469968,
AA569387,
AA551503, AL119984, AI590689,
AA831375,
AA682912, AL041706, AL046205,
AA713815, AL038785, AI287528,
AA857486,
AI439210, AI355224, AI305547,
298473,
AW341903, AA977743, AI312309,
AI608771,
AI249997, AL048925, AI674873,
AI434706,
AI623898, AI888752, AW167372,
AL022476,
AC004814, AL008716, AC007676,
AL132987, AC006285, AP000501,
AC006057,
U62293, AC000353, AC006312,
U63721,
AC005057, AC005740, AL035419,
AC003003, 298051, X60459,
AC005921,
AC006449, AL022322, AC009516,
AC007536, AC016025, AL022163,
AL022238, AC007308, AP000350,
AC004491,
AC004812, 283822, AJ003147,
AC007057,
AP000152, AP000117, AC004825,
U95742,
AL031311, AC002425, AL109758,
AC004019, AP000112, AC007036,
AC005288, AC004263, AC004858,
400
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL133485, AC005358, AC007011,
AL035659, AC002430, AF053356,
285986,
AP000300, AC000003, AP000044,
AL034549,
AC006111, AC002996, AC005529,
AC006088, 299716, AL109798,
AC007314,
AL035587, AC004890, AL117258,
AP000297,
AL049869, AFI96970, 293241,
AC006530,
AC002456, AL049745, U91322,
AC005102,
AC002126, AC004933, AP000045,
AP000113,
AF109907, 286090, AL050318,
AL023575,
AP001053, U52112, AC007384,
AC007114,
AC006536, U91321, AC005332,
AC005821,
AC005412, U85195, AC004643,
AC004383,
L44140, AC005829, AC005089,
AL022721,
AC003664, AC005527, AC004531,
AC0049I3, AC000035, AL049569,
AC004815, AC000025, AF045555,
AC006001, AL049757, AL024498,
AC005839, AE000658, AF001552,
AL049795,
AC006511, AC006211, AP000031,
AC005914, AB001523, AC007014,
AC004895, AC006213, AL022329,
AC005295, AL022315, AC002492,
AC002115, AC016026, AC004477,
AC005722, AC002312, AP000555,
AC002310, AC002094, AC005844,
AD001527, AL049780, AC006006,
AL096701, AP000962, AC005874,
AF134471,
AC002300, AC002544, AL022316,
AC007686, AC005231, AL135744,
286061,
AL034417, AC004638, D87675,
AC020663,
AC002470, AL035684, AP000193,
AC005015,
AC005086, AC004851, AC004876,
AC005175, AC002400, AL117354,
AC005594, AL049712, AC006925,
AL049779, AC007245, AC004382,
AC003101, 297054, AC016831,
AC007216,
AC007510, AC007664, AC003080,
AP000356, AC004821, AL080243,
AL034420,
AL034451, AC006480, AL049694,
AL022323,
AC002045, APOOOISI, AP000010,
AL03I276,
AC006160, AL031659, AL023807,
AC004253, AC006023, AL049766,
AC006487, 295115, 284487,
AC006946,
AL031427, AF139813, AF088219,
297196,
AC006116, AC005531, AC003982,
AC008372, AC005520, AC002303,
Y14768,
AP000552, AL031666, AC005822,
AC006241,
AF190465, AL021453, AC002395,
AC006254,
AF111I68, AF1I1167, AC00601I,
AC006544,
AC009247, AC005011, AC004534,
AL035072, U96629, AL009177,
293017,
AC005067, AC002349, AF015262,
AC002550, AF129756, L47334,
AL080242,
AC002350, AC018633, AC005778,
AL078463, AC007225, AP000553,
AC007707,
AC004694, AL031587, AJ229043,
AC006050,
AC005081, and AC005046.
HLDQK77 190 1169219~ 1 - 15 - AW385785, AA430300, AA541688,
2844 2858
401
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA776700, AA679037, AA573270,
AA126614, AL045796, AI268236,
AA682186,
AI963606, AI926591, AW192904,
AI924827,
AI922590, AI032288, AI375804,
AA705172,
AW081541, AI800450, AA694514,
AI130883,
AA931725, N25288, AI270687,
AI366906,
AW058362, AI683319, AA436891,
859176,
AI597744, AI446542, W69578,
AW453004,
AI911821, AI095665, AA687634,
AI130013,
W69579, 859232, AA722782,
AI587015,
AI191864, AA398533, AA676733,
AI476374,
AA115447, AA554327, AA759328,
AW242281, AI139766, AA042956,
AA886732, AA664356, AA358590,
AA135916, AI565897, AW304844,
AA618576, AA916086, 866162,
H71919,
AA363371, AA430199, AI370031,
244808,
AA320329, AI934183, AA393105,
AI004140,
AW452852, AA135927, AA042816,
AA135926, H44791, AA813424,
AI865731,
842647, T35731, 827785, T32691,
AI857286,
AW008428, AI631988, AA115446,
AA678468, AW075384, AI569918,
H44790,
AI918635, AA603858, AA601518,
H42641,
AI745618, AI445766, 827874,
AI939990,
AA677131, AW364938, AI569374,
AW029062, C01947, and AA732827.
HSCKD11 191 9738941 - 796 15 - 299396, AL036418, AL038837,
810 AL037051,
AL036725, AW392670, AA631969,
AL039074, AL036924, AL119497,
AL036858,
AL038509, AL039564, AL039085,
AL039156,
AL039108, AL039109, AL039128,
AW372827, AW384394, AL119457,
AL037094, AL039659, AL119319,
AW363220, AL036196, AL036190,
AL119324, AL037639, AL119341,
AL119484,
AL119391, U46350, AL119522,
AL038531,
-- U46341, AL119443, U46351,
AL037526,
AL036767, AL037082, AL119483~
AL119363,
AL119355, AL039625, AL039648,
AL045337,
U46347, U46349, AL036238,
AL134531,
AL11.9335, AL042909, AL119418,
AL119396,
AL039678, AL039629, AL039386,
AL119496,
AL039423, AL036268, AL038447,
AL039150,
AL037077, AL037085, AL038520,
AL119444,
AL037205, AL040992, AL119439,
AL134533,
AL036998, AL036733, AL037615,
AL119401,
AL038851, AL042965, U46346,
AL134528,
AL042614, AL042975, AL134538,
AL042984,
AL037027, AL119399, AL039410,
AL134920,
U46345, AL037178, AL043029,
AL036679,
AL042544, AL043019, AL042542,
AL036719,
AL043003, AL042551, AL036191,
AL042450,
AL036765, AL037054, AL119464,
AL036774,
AL037021, AL036886, AL036836,
AL036999,
AL036158, AL036964, AJ243342,
AR066494,
AR060234, A81671, AR023813,
AR064707,
AR069079, AB026436, and AR054110.
HDPLT62 192 9739451 - 796 15 - AW392670, U46341, AL119497,
~ ~ 810 AL119443,
402
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL119483, AW372827, AW384394,
AW363220, AL119319, AL119457,
AL119324, AL119396, AL119363,
AL119496,
299396, AL119484, AL119341,
AL119391,
AL119355, U46350, U46347,
U46351,
U46349, AL119444, U46346,
AL119335,
AL134920, AL134533, AL119439,
AL119522,
AL134518, AL134902, AL042975,
AL134526,
AL134538, AL119399, AL042965,
AL037205,
U46345, AL042970, AL119418,
AL042614,
AL134531, AL043029, AL042450,
AL042995,
AL043011, AL042544, AI142139,
AL042542,
AL043019, AL042984, AL042551,
AL043003,
AL119464, AL119488, AB026436,
AR054110, A81671, AR060234,
AR066494,
and AR069079.
HNTCU89 193 11377601 - 171515 - AW368397, AI679767, AI298034,
1729 AI681770,
AA379823, AA135903, D62730,
AI572778,
AI500061, AI623155, AA641818,
820540,
AI590043, AW075929, AI620056,
AI678623,
AI479292, AI860027, AI598I32,
AI819545,
AI918809, AI630932, AI539260,
AI678480,
AI688241, AW089844, AI633125,
AW188525, AI628325, AI522052,
AI768496,
AI611810, AI621341, AI500714,
AI927233,
AI277260, AI589428, AI918677,
AA580663,
AW118518, AI364167, AI440399,
AI474093,
AA767177, AI524179, AI521560,
AI699823,
AI279677, AI829432, AI696340,
AW238688,
AI671673, AI636507, AI913476,
AI699020,
AA830709, AW051088, AW080157,
AI358271, AW129019, AW167201,
AI918449, AI868740, AI744268,
AI473426,
N33175, AI627988, AI300304,
AI470717,
AI686808, 832821, AW198090,
AW084425,
AI357752, AI866419, AI698391,
AI538564,
AI915291, AW152182, AI579901,
AI582932,
AI784145, AI872423, AI619820,
AA019328,
AI540831, AI635216, AI889189,
W46378,
AW191844, AI920817, AL037602~
AW148536, AI654286, AI866469,
AI435253,
AW022808, AL037582, AW104641,
AI498067, AI697045, AA053669,
AI884318,
AW149937, N21402, AI638644,
AI370623,
AI570056, AI868680, AI432942,
AI889862,
AI688858, AI418681, AI678446,
W74529,
AI890907, AI419826, AI701097,
AI961414,
AW088691, AI702527, AW004606,
AW008226, AI499570, AI673140,
AI683173,
AI802574, AI241923, F34241,
AI561356,
AW083374, AW149329, AI537677,
AI075885, AW105296, AW148882,
AI349482, AI888095, AW088717,
AI860609,
AI859991, AI446511, AI689557,
AI800380,
AI636727, AI500514, AI475331,
AW162194,
AI925541, AI913630, AI499335,
AI927256,
AI690813, AI434731, AI289791,
AL118512,
I48978, A77033, A77035, X99971,
I33392,
AR038854, I48979, Y14314,
I61429, E07108,
403
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
A41579, I89947, AF072546,
A58545,
AF106697, AL080159, A31001,
AL137554,
AF061981, A18777, A52184,
U75604,
U80742, AL050366, AF026816,
S82852,
E12747, A21103, AL117587,
213966, 282022,
U97675, AR034821, AL080148,
X99226,
AL080146, AL080227, AL031732,
AF087943,
AF126488, 297214, AC004213,
AL137530,
AR023871, AL137574, U73682,
AL050138,
AL137478, A76335, and AL050155.
HELDY60 194 9458151 - 378 15 - W03943, and T83618.
392
HGBG022 195 11280131 - 137815 - AI927400, AI678696, AA947645,
1392 AW295277,
AA884167, AW296908, AA947188,
AI984289, T28629, 211502,
X80208, and
X80209.
HFXDP53 196 5788681 - 307 15 -
321
HMTAV95 197 6149361 - 395 15 - AB023187, AL137000, AL137000,
409 and
ALI37000.
HDPGS68 198 11822621 - 2468I5 -
2482
HCGME42 199 12037231 - 159015 - AW001430, AL048542, AI291283,
1604 AI185656,
AA043360, AA043359, AW058241,
AI348516, AI088612, AA971411,
AA740344,
AI354980, T82354, C032I6,
AAI51718,
T86918, AI921053, T86917,
AI273966,
AI800408, and C01482.
HLWAV41 200 11590741 - 172115 - AI002566, AI928181, AI659351,
1735 AW003718,
AI659661, H17004, AA207123,
AW389723,
AA580056, AA368259, AA641818,
AI884318,
AI569583, AI570807, AI469505,
AI241923,
AI249962, F27788, AI636588,
AI568138,
AI802542, AW026882, AI288050,
AI537261,
AI433157, AI702073, AI915291,
AI270706,
AW 131294, AW 104141, AI499285,
AI633125, AI538564, AWI52I82,
AI277008,
AL037582, AL037602, AI628331,
AI540458,
AW079572, AI473536, AA833760,
AI619502,
AI440239, AL040241, AI624084,
AI345416,
AI345612, AI635016, AI866040,
AI923370,
AI932794, AI3454I5, AI799674,
AI580436,
AI613038, AI670009, AW150794,
AI677796,
AI491710, AI249877, AI824576,
AL046466,
AI624293, AW051059, AW054964,
AI866770, AI288285, AI635216,
AI280732,
AI69839I, AW167021, AI500061,
AI889189,
AL046595, AI587606, AW083778,
AI648509,
AI798456, AI352274, AW008166,
AW129230, AW051088, AI536638,
AI538829, AI254731, AI866469,
AI868931,
AI499393, AI539771, AI559296,
AL038605,
AA806720, AW079409, AL046618,
AI609375, AI470674, AW080746,
AI242248,
AI281772, AI571439, AI934011,
AW078712,
AI537187, AI673363, AI355827,
AI537024,
AI687127, AI926790, AI270429,
AI956080,
AI890833, AI909641, AI690748,
AI564719,
AI635461, AW149925, AI590043,
AI638644,
AI690784, AI890214, AI687809,
AW148363,
AI620089, AI247293, AI612750,
AW006032,
AI819326, AI634345, AW118518,
AI61I738,
404
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI376425, AI800155, AI866801,
AI589668,
AI610895, AI357940, AI432644,
AI623941,
AI932949, AI627988, AI799470,
AI309306,
AA848053, AI637584, AI579901,
AI559619,
AI352497, AW161156, AI468872,
AI174394,
AI280661, AW 104724, AI680162,
AI244249,
AL040243, AI766348, AW167228,
AI934259,
AI554821, AI564259, AL134712,
AI682891,
AI539847, AW104827, AI445025,
AW 198090, AW 132056, AW
162194,
AI871697, AI432030, AI561231,
AI625079,
AW020358, AI640729, AI818980,
AI591387,
AI540674, AW085786, AI933903,
AI865334,
AL079963, AW265004, AW 170673,
AI471909, AI923989, AI872154,
AI367680,
AI567128, AW024360, AI635287,
AI686817,
AI694157, AI886181, AW075667,
AI499963,
AI591075, H89138, AW148408,
AI612913,
AW150457, AI633000, AI281757,
AW190194, AW170725, AW075669,
AW087934, AI824746, AW090550,
AI921281, AI469112, AI362248,
AI591310,
AI687362, AI912356, AW083374,
AW193530, AW073270, AI817523,
AI651840, AI610690, AW262767,
W74529,
AI653979, AI682971, AI469532,
AI933589,
AW051212, AA479803, AI580190,
AI376872,
AW151893, AL039086, AW078650,
AW087207, AW302960, AI859991,
AW162118, AI582932, AI473799,
AI872423,
AI869377, AW058304, AI670002,
AI521560,
AA830821, AW088628, AI921464,
AW131999, AW020397, AB007935,
AF031174, AC005815, U00763,
AF061943,
U01145, X98834, AL117432,
AL137533,
AF061981, AF182215, AL050149,
I26207,
I89947, M81784, AF139986,
I48978,
AL080159, U78525, AR038854,
AR034830,
I96214, A08913, AL137658,
A18777, A08912,
AL050366, X63574, A77033,
A77035,
282022, AL137463, A08916,
A08910,
297214, A08909, AL133637,
A08908,
AL117460, X72889, E07108,
I09499, U35846,
A18788, AJ000937, AF183393,
AF100931,
D16301, AF090901, X53587,
AL080124,
AF153205, I66342, 578214,
AL133014,
I89931, A12297, Y09972, X84990,
AF113690,
AL122110, 575997, AR020905,149625,
AB016226, X82434, AF215669,
Y11254,
X80340, AF111849, AL133016,
ALI37488,
X93495, AF032666, AJ005690,
576508,
I48979, AL110280, Y08769,
Y07905,
AF162270, A21103, A65340,
A65341,
E06743, AL137271, AL137574,
AL080148,
AF030513, AL133113, E12747,
AL137476,
A15345, AF098162, AL117648,
AL050116,
AF110520, AL049382, AL080163,
AL137480,
AF207750, AF113019, AF177401,
AF078844,
AR038969, S36676, AL137478,
L30117,
405
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL137550, AL133665, AF205861,
AL023657,
AF185576, U80742, AR034821,
A03736,
AF067728, Y11587, AF087943,
AL080154,
AL117416, A08911, AF067790,
AF090934,
AL137538, AL122100, AF106657,
AL050393,
AL133565, AF026816, I89934,
I89944,
E03348, AF126247, AF118094,
E03349,
ALI33640, AL133081, I42402,
AL050172,
AB007812, AL133080, AL110221,
AL050155,
AL133072, X65873, E02221,
AF102578,
AL137459, AF111112, AL050277,
AF113677,
AL137557, AF069506, AL110196,
A93350,
AL137711, AL117435, X83508,
L19437,
A76335, AF106697, E01314,
AL133075,
AF061795, AF151685, A45787,
AL096744,
577771, AL117440, AF000145,
X63410,
AF113689, U95114, Y14314,
AL137560,
AF118090, E02349, AF111851,
AR059958,
AL117649, S79832, AF137367,
AF079765,
AL137521, AF022363, AF008439,
AF104032,
AL137479, AR011880, AL133560,
A58524,
A58523, AR013797, AL133067,
AL050024,
Y10936, AL049430, I33392,
AF113699,
AR029490, AL 122106, AF210052,
I17544,
AF017152, AF090903, A23630,
568736,
AL133619, AL034417, AL122121,
AL137292,
AJ012755, D83032, AL080074,
AF012536,
A08907, AR000496, AL133645,
I03321,
AF132676, U39656, AF061836,
AL137529,
A08915, AF146568, AL080126,
AF003737,
X79812, AL049452, AF125948,
AL117583,
Y10080, AL122118, E01614,
E13364,
AF113691, AF113013, AF106862,
AF028823,
I80064, X87582, AL050138,
E05822, E04233,
A83556, and AL133557.
HLDBL95 201 12206901 - 250015 - AA706969, AA706949, AW117414;
2514
AI686177, AA593882, AA470550,
W79014,
AI688782, AI651586, AI989558,
N55354,
AA989479, AI582645, AA470503,
AI696078,
AI206545, AI208752, H73962,
AA188667,
H73294, T57251, AA298359,
T56655,
AA298655, W80406, AI393057,
AW015923,
242132, 238397, AW161872,
808414,
N77361, AI016001, AI815785,
AW006977,
AA476762, AW182225, AI680045,
AI051883,
AI208384, AW364174, AI758186,
AA783039,
N74662, AI078359, AI910556,
AI001928,
AA476759, W05033, AA718953,
AA813472,
AI937587, AI305280, AI148013,
AI142301,
AA309595, AI184400, AF134918,
and
AF086122.
HHFGP83 202 8281621 - 325 15 - AC026329, and AC026348.
339
HEGAR66 203 11991371 - 570 15 - AA339802, W79688, and 848751.
584
HAPPY24 204 11377891 - 131815 - AW295848, AI132995, T48851,
1332 AI247571,
T48852, AA344713, AW131386,
AWI90967,
AA400508, AA400618, AA835515,
AF170485, AJ007395, AF193441,
AJ130710,
AJ130711, AF135027, AF195092,
AF223403,
AJ130712, and AJ130713.
406
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HE9TK49 205 8563431 - 314 15 - AF124351, AB012043, AF134985,
328 AF126965,
AF126966, AF134986, AF125161,
AF027984,
AJ012569, AC004590, AC004590,
and
AC021491.
HORB054 206 8706741 - 566 15 - AW 166235.
580
HFKFL92 207 12175981 - 943 15 - AI859297, AW301122, AI819813,
957 AA625654,
AA610590, AI601169, AI521678,
AA770693,
AI148402, AI797531, W56364,
AA043176,
AA399245, AI224414, AA412225,
F25596,
AA760787, AA044224, AA044343,
H49207,
H49393, W56338, H46471, AA483644,
F35724, H41195, 883432, H45052,
H46298,
T71570, H46110, 845220, H47011,
H41194,
H46033, AA810028, H50393,
800715,
AA593682, H50355, 240409,
AA043175,
H45090, C14331, C14344, AA809122,
D59502, C03092, D80022, C14429,
D80038,
C14407, D80157, D80439, D80212,
D59503,
C14389, D59619, D80210, D80240,
D80247,
D80166, D80045, D80219, D58283,
D80043,
D81030, D80268, D81026, D80064,
D80195,
T11417, AA305409, D80391,
D80164,
C06015, D59787, D59859, D80522,
F13647,
AA305578, D59467, D51423,
D51799,
D59275, D80253, C14046, D80227,
D80193,
H67866, C15076, D80248, AI535686,
D80251,
D80196, D80133, D51759, D80269,
D59610,
D80366, D80188, D51022, D80258,
D59653,
D50979, D50995, D59927, C14014,
D51060,
D80014, D57483, T03116, AW178893,
D59889, D80302, AA514186,
D80024,
AI557751, H67854, AA514188,
D58246,
D81111, D45260, C14227, AW377671,
D80241, D51103, D80378, D59317,
AW177440, C14973, D60010,
D51221,
AA514184, AI525917, AW360817;
D59474,
AI525920, D59373, AW375405,
AW360844,
AW360834, D58101, D59551,
AI525923,
C05695, T03269, AW360811,
C14957,
C75259, D80168, AA305720,
AW360841,
D60214, AI525227, D51213,
AI525235,
AW178907, AW177511, AW178906,
AW 178908, AA285331, AW 177501,
AW352117, AW179328, T48593,
AI557774,
AW375406, C16955, AW378534,
AW352171,
AW179332, AW377672, AW179023,
AI525242, AW178905, AW377676,
AW177731, F13796, 233452,
AI525912,
T02974, AW378528, AW178762,
AW179019,
AW179018, AW378533, AW366296,
AW352120, AW378532, AI525925,
AI525215, AW177505, C14298,
D45273,
AW378542, AW367950, AW352170,
H67858,
D59627, AW360855, C05763,
AW178914,
AW378543, N66429, 221582,
D80949,
AW179020, AW178775, C06084,
C13958,
AW178909, C14077, 230160,
AW178774,
AW378539, AW177733, AW178754,
AW 179024, AI525237, AW 176467,
D51053,
407
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW177734, C04682, AW177456,
D51250,
AW178781, AW178911, AW378525,
AW378540, AW352163, T02868,
AI525222,
D59695, AW179004, AW369651,
AW179329,
AW 179013, AW 179009, AW 178980,
AW178986, AF151901, AR060385,
A62298,
AR018138, I14842, AF058696,
A62300,
A82595, A84916, AB028859,
AR054175,
AJ132110, AR008278, AR008277,
AR008281,
AB002449, I50126, I50132,
I50128, I50133,
X67155, Y17188, A30438, A67220,
AR016514, D34614, AR016691,
AR016690,
Y17187, U46128, AR060138,
A45456,
A94995, D26022, A26615, AR052274,
A43192, Y12724, A63261, A43190,
AR038669, AR062872, A64136,
A68321,
A25909, I82448, AR066488,
X68127, Y09669,
AR066487, A70867, D89785,
A78862, I79511,
AR008443, X72378, AF123263,
D88547,
AR032065, and AR008408.
HETLT82 208 8832731 - 640 15 - AW003206, AI563909, AI809945,
654 AA424228,
and AB014526.
HWAEU35 209 11998541 - 111115 - AI821267, AA669727, AL042753,
1125 AL138455,
AW410784, AW029515, AA760655,
AI380617, AI064955, AI253987,
AA594157,
AI560085, AW082076, AL045077,
AI791227,
H73550, AW007980, H90114,
AC005670,
AL031680, AC005081, L78810,
AC005592,
285996, AC005015, AC005291,
AC005484,
AL033527, AC003043, AL121603,
AF196779,
AC002316, AC005921, AC007283,
AC007390, AP000557, AC006530,
AC006160, AL022336, AC000085,
AC007151, U07563, AC004383,
283844,
AL035587, AL009181, U91326,
AC005500,
U91323, U95739, AL022165,
AL031737,
AF113676, AC005746, U95740,
AC005527,
AC012384, AC005740, AC006115,
AC002464, 299716, AL022238,
AC004112,
AL022147, 298742, AC008055,
AL031121,
AF038458, AL049776, U91319,
AL031291,
AC005048, AC006480, AC004674,
AL031005, AC005859, AC005225,
AC007731, AC004883, AC004560,
AL133245, AC005815, AC007172,
AC002126, AL031286, AC006449,
AL050404, AC004263, AC003684,
AL034374, AC005697, AP000563,
AF001549,
AC005529, AC005368, AC005409,
AP000045, U91318, AC005105,
AC005102,
AC007277, AC005913, AC016830,
286090,
AD000812, AC007226, AC005391,
AC004686, AL031432, AL023575,
AP000696,
AC007298, AL121653, AC005568,
AC006468, AP000695, AL031659,
277249,
AL133404, AC005332, AC005822,
AC005939, AC006139, AC007664,
AC005940, AC007637, AC005886,
AC004837, AC005520, AC004605,
408
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AC004887, AF091512, AC005488,
AL035086,
AC009247, AC009784, AC002401,
293023,
AL133163, AC003689, AJ011930,
and
AC007011.
HMWDB84 210 10021671 - 2602 15 - AI659611, AI683629, AI798127,
2616 AW 150924,
AW377686, AW024683, AI933352,
AW008595, AA489064, AA913051,
AI818208, AW377683, AI418155,
823544,
AA488816, AA872894, AA972544,
T86112,
AI383891, AP001058, AB014553,
AF199028,
and AP001059.
HMSNC17 211 11378731 - 3788 15 - AA772172, AI633538, AA868788,
3802 AI400461,
AA854326, AA132453, AI239666,
AA053064,
AA424639, AI123127, AA932586,
AA053408,
AA132637, AA653368, AA345850,
AA960956, AL045709, AL037910,
AI016704,
AA468322, AI821467, AI252506,
AW277109,
AI924702, 883097, AI335387,
AA503168,
AA808263, AW263864, AA492313,
H45320,
AW192330, AA557486, AL135698,
AA814778, H10143, AL037683,
AA632845,
AA584489, AI859834, AL041375,
AW268190, AI732157, AI732158,
AA601680,
AI708444, AI132963, AA501614,
AI791150,
AA857381, AA715706, AW304584,
AA657752, N22032, AL044858,
H10859,
AW 148507, AA457685, 894252,
AI014920,
AA598649, 892629, AA508873,
AW069227,
AA579469, AI633168, AI872503,
AI017251,
AA634209, AA904137, AA805048,
AI538812,
AL046782, AL133243, AC004990,
AL031295,
AC004685, AC002039, AC002045,
AL133163, AC004386, AC007172,
U95742,
AC005288, AL035587, AL035089,
AC006285, AC006251, AC007216,
AC004797, AF111168, AC007227,
AC002558, AC003029, AF196779,
AF001549,
285987, 283844, AL023803,
AL022320,
AL008715, AC005726, AC004019,
AL049694, AC002347, AC004106,
AC005921, AL049779, AL035072,
AC005015, AC002288, AD000813,
AC00767I, AL035455, AC006539,
AC004791, AC002418, AC002115,
. AF053356, AL049749, AC004067,
AL109865,
282214, AC006077, AC004050,
AF037338,
AC005189, AC005874, AF134471,
AL033504,
AL031595, AL110502, AC005291,
AC005046, AP000552, AC004148,
AC001228, AC000052, AL031255,
AL035400, AL034549, AC002375,
AL121653,
AC002551, AL031662, AP000690,
AL109963,
AL022396, AC005971, AC004819,
ALI17694, AP0005I8, AC005243,
AC003071,
D88270, AL050338, AL121658,
AC005722,
AP000555, AC008149, AC002091,
AL008725,
AC005678, AC005411, AC004777,
AC007191, AC005747, AC002425,
AC007388, AL031433, AL117355,
AL096853,
409
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL137100, AC005003, AL049835,
AC005242, AC005212, AC005725,
AC006571, AC006530, AL021578,
AC003043, AC004888, AL022165,
AC002301, AL022313, 298742,
AL031289,
AC009743, AC005699, AC005081,
AC005192, AC005013, AL023879,
AL080243, AC003982, AC003959,
AD000092, AL031577, AC004522,
AC003037, AC004938, AC005821,
AC002070, AF111169, AC007664,
282097,
AC005940, AC003108, AC004887,
AC004584, AC012085, AC005972,
U91326,
AC009178, AL031003, L11910,
AP000359,
AP000023, AC005234, 282194,
AP000558,
AB023051, AF181897, AC002394,
AL022328,
AC004129, AL008635, AC004837,
AC007546, AL079342, AC005875,
AC005695, AC006487, AC007285,
AL132777, AP000563, AC007312,
AL031057,
AC003080, AC008498; AC002544,
AC003664, AC004263, 293241,
AC007055,
AL031286, AC002527, AC005592,
AC006270, AC000003, AC007358,
AL022318, AC005899, AC005772,
AC005280, AB023049, AL049845,
AC005393, AC003688, AC004816,
AF196969, AC016025, AC002543,
AC006441, AC005839, AL035683,
AL109753, L78833, AC005755,
AC004125,
AP000476, AFOOI550, AC004003,
AC005859,
AC003036, AC004056, AC005160,
AF205588, AL133546, AC006211,
AL049554,
AL035461, AC004471, AL117337,
AC005037, AC004859, AC004878,
AJ010770,
AC004659, AC006479, AL121915,
AP000344,
AL008721, AL049570, AC007435,
AL122021,
AL034548, AC004821, 284466,
AC009464,
AP000556, U76377, AL132992,
AC006241,
285986, AC005907, AL121748,
AC002326,
AC006262, 295118, U52112,
AC007114,
AL035451, AC007666, AC007237,
AL035530, AL049871, AL049829,
AF165926,
AC003107, and AL133500.
HPWAY10 212 11234531 - 1257 15 - AI027613, AA332875, AW367440,
1271
AW376896, AA330257, AL042522,
AW367550, AW304212, H80390,
AA447076,
AI923485, AW316546, 808512,
AB023178,
230174, AC007676, AC007842,
AC004696,
AC005498, AB021641, and X78933.
HOHCE52 213 11352911 - 1716 15 - AW419308, AI694792, H29647,
1730 H29648,
AI799607, AI884522, AI350084,
AI754767,
AI733856, AA613627, AI284543,
AL047349,
T74236, AA714110, AI267356,
AA501782,
AW275432, AI267450, AI912401,
AA574442,
AI223626, AI859438, AI291439,
AA595661,
AA441810, AI797998, AI061313,
AI537995,
AI130709, AI753672, AA742815,
AI369580,
AA828047, AI814682, AW068008,
410
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW068007, H73550, AI254770,
AA013168,
AW419389, T74524, AW341978,
AW067788,
AW148775, AI251034, AI922224,
AL119247,
AI355246, AI160786, AA584484,
AA651639,
AL047467, AI250552, AI469599,
AA019973,
AW117740, AI922231, AW302048,
AI292317, AI679002, F12574,
AA706495,
AW438542, AA714011, AW303098,
AI251284, AI251203, AA483606,
AA536040,
AW103758, AI821608, H29914,
AI984168,
AI280504, AA433894, AW161016,
AA297802, AA570740, AA298789,
AI049676,
AA488689, AI753365, AI955465,
AW338021,
AA287570, AA504818, AC020663,
ABO11129, AJ003147, AL049646,
AC002310,
AP000348, AF118808, AF124523,
AC004877,
AC005261, AC004232, AC007731,
AC005500, AC007228, AC004890,
AC003682, 298304, AF146367,
AC006130,
U82695, AC004017, AF205588,
AF091512,
AC003002, AL021918, X82126,
AC006213,
AC006116, AL117337, AC007842,
U82672,
AL031393, AC005678, 298745,
AC007676,
AC021092, AL031985, AC003006,
AC005324, AC006539, AC000378,
AC004821, AL022345, AL021997,
AC005822, AC002301, AL031659,
AL031255, AF001549, AC004696,
AC006059,
AC006241, AC002519, AL096761,
AC004841, AC005365, AF088219,
' AC006455, 284483, 295704,
299716,
AL135744, AC007227, AC003973,
AL080317, AC006557, AC006486,
AL031120, AC007707, AC004797,
AC004973, AC006965, AL135960,
AJ131016,
AC004150, AC012627, AL133371~
297630,
AL021878, AC002287, AC005914,
AL078611, 283844, AC000026,
AC003029,
AL022163, AC008115, AC006211,
AC006057, AL022393, AC005488,
AC005071, AC006016, AC004782,
AC004893, AC008045, AC007160,
AC007993, AC005666, AC004491,
AC001234, AP000510, AC007285,
AL022147,
AC006430, AC004686, AL049761,
AC007243, AL031730, AF060568,
AC002565,
X60459, AC003037, AC018725,
AC005225,
AF124730, 282190, AC007934,
AC005231,
AL035587, 293023, AC006501,
AC009336,
AC005696, AC002314, AL031005,
AL078638, AC002350, AC013256,
AC005520, AC002115, AC004929,
U91321,
284487, AC005498, AC005078,
AL049557,
AC004674, AL109627, AB023049,
AC005480, AC004778, 293017,
AC003109,
AC004675, AC008126, AB023048,
AC004476, AC004851, AF217403,
AC004881, AC007277, AC006270,
AC005041, 284480, 274477,
AC007325,
411
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL024507, 282245, AC000085,
AL022165,
AC005539, AL031776, AC004000,
AF067844,
AF111168, AC003007, AC005004,
AC000134, AL035423, AL121603,
AL022326,
AC005015, AC002316, AL031277,
AC007358, AC004594, AL034420,
AC007790, AL031656, U91326,
AC005288,
AC009516, AC002480, AL133448,
AC005400, AC005243, AC003030,
AF006752, 298036, AP000346,
AB014078,
AP000553, AL022336, AL049869,
AP000172,
AL136295, AP000057, 282215,
AP000514,
298946, AP000117, AC006597,
AC004895,
AL021407, AL022318, AP000125,
273420,
AL022323, AC005796, AL021808,
AL031282,
AL008730, AC000393, 295115,
AL035530,
282208, AC008394, AC003043,
AP000501,
AC005332, AC002477, AL117694,
AL035462, AC006163, AL096703,
U91322,
U47924, AC007055, 279997,
AL049872,
L78810, AL022322, AF111169,
AC004650,
U6372I, AC005031, and AL109952.
HLHCR16 214 9101231 - 379015 - AA402528, AI379350, AA716107,
3804 AI123557,
AI127175, AA234106, AA234698,
AI039768,
N77999, AI580137, AA424560,
AA419490,
AI334141, 871349, AI224976,
AI417798,
AI080508, N58410, AI8I8475,
AA424657,
N91089, AA399612, AI144265,
AA399137,
AI498363, AA410986, AA235306,
AA399148,
AW292497, AI249102, W86869,
AA115407,
H81257, AI077499, H00194,
H45499, 801206,
AW 104245, AA234880, AA367417,
AA852175, F05822, AA853077,
AA852176,
882875, H81245, AA298421,
871350,
822096, H81585, AI985171,
T49265, H81591,
AAl 15408, 864037, T54283,
AI492930,
AI492932, 882876, 881695,
833935, 834138,
825630, H81595, 832025, 881696,
T49264,
895688, 801319, 822040, 221579,
833043,
238741, AA514393, T97662,
T34993,
AA705441, D79105, 832078,
H45500,
AA707178, 830943, H81576,
H81250,
AI032721, AL079279, and I76197.
HFKJ015 215 9108281 - 526 15 - AI148246, AW241903, AA234558,
540
AC007731, AC005500, AC000096,
AC007731, AC007731, AC005500,
and
AC005500.
HEMCL65 216 9109001 - 453 15 - AI902552, and AI902562.
467
HMAMB94 217 9109091 - 627 15 - AA158332, 890961, 890977,
641 and 890972.
HAHFI44 218 11359751 - 204515 - AA179600, AA179599, W30992,
2059 AA196208,
F24218, N98761, AI400346,
W51748, F34748,
F16301, F32501, AA196149,
and AA599376.
HKMLN95 219 9140831 - 196515 - AA551127, AI692457, AI765517,
1979 AI749951,
AI631959, AI129348, AI949762,
AI672100,
AI609235, AI950134, AI692456,
AI651144,
AW189207, AI935651, AA868261,
AI151427,
AA044198, W63627, AI521732,
AI949853,
AA161274, AW300441, AI708643,
AA868518, AI962729, AI150783,
AI015909,
412
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA595810, AI281874, AI819752,
AI479243,
AI745688, AI341421, AW022195,
AW027973, AA132312, H99174,
AA429830,
AA070213, N52408, AI913890,
AA856798,
AI745679, AI554270, AA442125,
AA554278,
AA161275, AA702375, AW016589,
N24457,
AA070298, AA969821, AI635327,
AA699477,
AI458226, AA043064, AI982949,
AW439708,
AI687133, AW272645, AW177545,
AA946996, AW341771, AW177556,
AI342767, 899590, N95053,
AW402507,
AI074359, AI630618, H84183,
AA557498,
825323, AA446257, 843298,
AW243239,
AI583569, AW194714, AA551069,
892184,
AA557798, AI433955, AA714014,
N66644,
AI824194, 887671, T57956,
AA313194,
AI921595, AI208421, T57874,
AA027072,
AA156655, 887665, AI370681,
814400,
AA352103, 887659, AA860614,
AI140574,
824026, N58584, 887672, 238717,
AI870045,
AW151040, 884296, AA542839,
AI277638,
892288, AA307482, AI954284,
AI472463,
N67635, AA442124, 818926,
884303,
AI632684, N72814, AI472552,
242525,
884309, T94235, 826521, AA091407,
AA876334, T26330, AA565557,
AA609829,
N53150, AF078850, U81186,
and AF064635.
HCQCI06 220 9150001 - 119015 - AI123952, AI751915, AA343597,
1204 W79144,
AA345718, AA304549, AA256582,
W81545,
D45547, AL117664, AC068763,
AC068763,
and AC069223.
HE8EI09 221 12067031 - 297115 - AW 118853, AI128005, AI304951,
2985 AI806634,
AA864943, AA001739, AI859224,
AI014552,
W37987, AI422749, AI554797,
AA776417,
AW072232, AW192477, AI023423,
AW451522, N51229, AI306577,
AI206406,
W37988, AA220245, AI888568,
N24284,
AA477029, AA022682, T55949,
AI538443,
AA527439, AA282898, T57196,
T94775,
AA878001, AI161044, AA022801,
AA587858,
AI828446, AA911458, AA813028,
H80241,
AW179043, W03712, N32175,
AI022374,
AA309975, AA321764, AA884339,
W79912,
AI208820, AI420754, AI276411,
W02715,
W27545, AA353845, AI499535,
W25734,
W78127, AA001808, AA370906,
H56404,
T94024, AA321763, AI869412,
AA548566,
AI273624, AI339735, AW020249,
AA256928,
AA029852, AA334196, AA872708,
AA321910, 822900, AA875968,
AI146581,
AA255437, 823002, H56188,
AI824776,
M85881, C01054, AA322397,
AA339184,
AA028982, L39210, and L33842.
HBODA38 222 9234561 - 188215 - AA196401, W79841, AA112831,
1896 AA197134,
C05212, W19681, AA195812,
225012,
AI004215, 230134, AA194641,
AI809925,
AA258550, 228480, F29133,
AA699576,
F20387, AI129717, AA194359,
AI079487,
AA195355, AA195094, AA931319,
F34387,
413
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
219343, F36761, H67895, AA258604,
AI378821, F19321, AI089231,
891150,
AI702453, AI288969, AI313118,
AI351843,
F31038, N56278, AI381419,
AA195356,
AA131264, AA195051, AA192095,
AI264911,
and AA086284.
HCYBK19 223 9254941 - 266415 - AI829726, AI809562, AI927757,
2678 AI927758,
AI927768, AW297770, AA165336,
AI638072,
AI149852, AW298053, AI365991,
AA904547,
H15885, AA985065, AI359235,
AW207262,
AI470080, AI421572, AA305419,
AA985170,
AW341104, AI423550, AI362528,
AI453702,
AI654827, AA927292, H91991,
AI365149,
AI365324, D81295, AI797740,
AI357382,
AI953516, AA909430, H01576,
AA969956,
AA379840, H52748, 837302,
AA905264,
243289, 862753, 818887, 868272,
H04859,
AA746048, T31617, H04764,
T78758,
244077, T32807, D60323, AA634475,
H01477, AI193962, H00918,
D81446,
M86147, AA983881, AA318875,
N64328,
AA165369, 239361, D62629,
T16370,
F03272, H00919, N34301, and
H46107.
HOFNH30 224 9283651 - 362 15 - AF186380, and AF127138.
376
HWMEV63 225 9311541 - 440 15 - D13626, and AC078816.
454
HUUDH57 226 11561741 - 251915 - AI888110, AI161293, AI889765,
2533 AI473943,
AI423941, AI248937, AI084822,
AI249135,
AA361076, AI334443, AI284640,
AW303196,
AW301350, AA521323, AA521399,
AW274349, AL138455, AL046205,
AL042753, AI963720, AL042853,
AA581903,
AW327868, AW419262, AW270382,
AL119691, AA515909, AI696962,
AI754955,
AI281881, AW238278, AW103758,
AA468022, AL044940, AL041690,
AA503473, AI110770, AA631507,
AA680243,
AI732120, AA610491, AL039958,
AA356078,
AA610493, AA584195, AW270270,
AA613203, AW439558, AA164251,
AL119649, AA613345, AA576336,
AI133164,
H10994, AL046457, AA179944,
AA446657,
AA613227, AI821714, AI792133,
AI791913,
AA737318, AL038474, AA682912,
AA523837, AA483771, AL138265,
AA657918, AL048925, AA994578,
AI799642,
AA744338, AI610159, AW088846,
AI669589,
F36273, AI370074, AW023672,
AI355206,
AI133262, AL120687, AI821785,
AA653618,
AI610920, AI567076, AA837677,
AA280632,
AA493471, AI733755, AA610783,
AA126035,
AA584082, AI200051, N23896,
AL042420,
AA806796, AI357823, AA126051,
AA533725,
AI471543, AA649642, AI801591,
AC005778,
AC005900, AL096776, AL049829,
AL121603,
AC002565, U95742, AL121915,
AC006213,
AC007298, AC005412, AF123462,
AL022328,
AC003977, U57009, AC007216,
AC004690,
AC004987, AC002059, AC007384,
AC004381, AC000353, AL031281,
414
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AD000092, AC002984, AC006328,
AC006344, AL122021, AC005250,
AL023284, AL023575, AC004019,
X54181,
AC005291, AF129756, AL022163,
AC007227,
AL096701, AL034420, AF015156,
AC002549,
AC006960, AC002430, AC005242,
X55926,
AC008372, AC005274, AL121934,
AF147275,
AFI 18808, AC007032, U66059,
AF124523,
AC006989, AC002385, 293023,
L04965,
AC007151, AC006999, AC007385,
AC004878, AL031053, U62317,
AC007285,
AC005969, AL020995, U18391,
AC005740,
AF146367, AL136297, AC005331,
AC005968,
U85195, AC006270, AC005815,
AL034351,
AC006501, AE000658, AC004263,
AC007392, AC006285, AC010072,
AC005102, AL031054, AC007919,
AC005019, U47924, AC005696,
AC000066,
U18394, AJ010770, AC00490I,
AL031390~
AC006195, AL023882, AC002289,
D83989,
AL031311, AL031662, AP000962,
AP000142,
AC003007, AL049757, U67832,
AP000557,
AC002390, AC004865, AC005768,
AB023054, AL035072, AC004694,
AC006241, AP000552, AP000504,
U69730,
AC008101, AC004502, AC006211,
AC006965, AC000041, AP000555,
AC007541, AL049776, D84394,
298744,
AC005527, AC004592, AC005154,
AC008079, 543650, AC005962,
AP000304,
AC005295, AP000359, AC007051,
. AC00582I, AP001054, AF027390,
ALI32992,
AC005747, AC005261, AC005859,
AP000047, AL078477, AC005909,
AF091512,
AL132712, AC000052, AP000049,
AP000433,
AC005216, AL034343, AC004491,
AC007043, 282244, AF227510,
AC004547,
AC009069, AL139054, AC002094,
AC018769, AC004049, AL035494,
AL035425, AC004539, L44140,
AL009051,
AL022727, AC004953, AC005529,
AC004879, AC002543, AF196779,
AR036572, U91328, AC004650,
AC004638,
AP000115, AC004890, AC005362,
U95740,
286061, AC006016, AC005246,
AF029308,
AL031775, 270289, AF001549,
AC009516,
AC009509, AP000548, AC000029,
AC007274, AC007458, AF064861,
AF067844,
D87675, AC006044, AC007245,
AC006139,
AC005257, AL008716, AL050331,
AL117258,
AC007376, AL049692, AC006252,
AC003037, AC007226, AC005378,
AL133500, AL035448, AL050097,
AC002994,
AL021453, AC004972, AF207550,
AC004970,
AL031597, AC016025, AC00773I,
AL096861, 299495, 298051,
AC007114,
AC004183, AC002316, AL133399,
AC006045, AC000072, AC000114,
AC004913, AC004626, and AP000959.
415
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
HDQFT77 227 11570011 - 135715 - AI582617, AW194919, AI393304,
1371 AI760916,
AI378837, AI628122, AI525818,
AA861720,
AI682246, AA775482, AI651311,
AA025281,
AI857832, AI340350, AI348117,
AI338259,
AI015680, AI242142, AI860137,
AA476668,
AI200562, AA862367, AA806615,
AW103824, AA968628, AA731250,
AA453588, AI559269, AI871538,
AA909432,
AA025321, AI540267, AA975563,
AI184361,
AI500004, AI474803, AI590227,
AL079963,
AI888953, AI702406, AI620284,
AL119863,
AI349645, AI673297, AW026882,
AW150578, AI312428, AI619502,
AI284484,
AI625079, AI537244, AA225339,
AI637584,
AI564719, AL048656, AI802542,
AA572758,
AL036403, AI340603, AI872711,
AI569583,
AI433157, AI524671, AW238730,
AI538716,
AA508692, AI926790, AI783504,
AI521012,
AL045500, AL036274, AL036146,
AI554245,
AI348897, AI251434, AI340582,
AW074993,
AW103371, AW074869, AI539771,
AW087445, AI872545, AI349004~
AW302988, AW183130., AW268220,
AL049085, AA427700, AI815855,
AI269862,
AI500523, AL036396, AA640779,
AI610307,
AL047763, AW071417, AI537677,
AI445432,
AI687728, AL040243, AL045266,
AI536638,
AI889376, AW104724, AI569945,
AW302992, AI432969, AI554427,
AI702073,
AI312152, AI345735, AI868831,
AI133559,
AI343112, AL121365, AI571909,
AW078529,
AI862144, AW268253, AW301300,
AI922901, AI349598, AI343059,
AI290154,
AI890833, AI349933, AI345608,
AI697137,
AI590120, AW132056, AW301505,
AI696612, AI497733, AI274508,
AI281773,
AL134259, AI313320, AI702068,
AI349614,
AI343030, AI866608, AI334450,
AI686877,
AI954183, AI284517, AI923989,
AI921248,
AI631107, AI440239, AW169527,
AI475451,
AI677796, AI702433, AI635461,
AI224992,
AI312146, AI312339, AI799199,
AI273142,
AI476046, AW 129106, AI269696,
AI281762,
AI800453, AI800433, AL043326,
AI633419,
AI498579, AI866002, AI433976,
AI630252,
AI591311, AI920968, AI682841,
AI866751,
AL036802, AW169653, AI610645,
AI537303,
AI445025, AW020693, AL038778,
AW089572, AI439478, AI271786,
AI828731,
AI572787, AL036631, AI282281,
AW075351,
AI539153, AW086113, AI869367,
AW148320, AI340627, AL038605,
AW075413, AI349937, AI500077,
AL135661,
AI569616, AI445165, AW 162071,
AI634345,
AL120736, F27438, AI648684,
AI801325,
AW008048, AI567351, AI570909,
AW002342, AL038565, AA613907,
AI491852, AI500706, AW085799,
AW081036, AA470491, AI567612,
AI250369,
416
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI500662, AI434468, AW023590,
AI925156,
AI539808, AI636719, AI309401,
AL041772,
AW071349, AI281772, AI469532,
AW075084, AA493647,AI784252,
AI950664,
AI340519, AI499512, AW021588,
AW051258, AW117746, AI611738,
AI632408, AI306613, AI308032,
AI59I316,
AI307708, AI289937, AI362637,
AI318280,
AF078164, AJ000937, AL133640,
I48979,
I89947, 578214, I48978, A08916,
AF090900,
AF078844, I89931, AL122050,
AF090903,
AF090901, AL122093, Y16645,
AF113699,
AL050393, AL117457, A08913,
AL122121,
AF079765, AL117435, A08910,
ALl 10196,
AF113013, AL117460, AF113690,
AL110221,
AL0501 I6, AL096744, U42766,
AF090943,
AL133075, AL050149, AF090896,
AF090934,
I49625, AF177401, I03321,
AF106862,
Y11254, AL137459, AL050146,
AF146568,
AF017437, AR011880, AL133560,
AL133606,
X82434, AL137550, Y11587,
A08909,
AJ238278, AL080124, AL133016,
AL133565,
AL049452, AF118064, AL1I7583,
X84990,
AL133557, AF125948, AL050108,
AF113677,
X70685, AF113019, AF113689,
AL050277,
AL049466, AL137527, AL049938,
AL133093,
AJ242859, 568736, AF104032,
AF091084,
AF118070, AL133080, AF113691,
AF017152,
AF113676, AL1I0225, AL117394,
AL080060,
AF113694, U72620, AL137557,
A65341,
AF111851, E07108, L31396,
AF158248,
AB019565, X72889, L31397,
AL049464,
AR059958, AF125949, AL080137,
A12297,
E03348, A93016, AF118094,
A77033,
A77035, AL049314, X63574,
AL137271,
AF097996, AF026124, AF183393,
AL122123,
A58524, A58523, U35846, A03736,
U91329,
E07361, AF087943, AL049382,
E02349,
282022, AL122110, AL050024,
AL049300,
AL117585, AL137463, AL049283,
AL049430,
AL050138, AL122098, U00763,
AF061943,
X96540, AL137538, AL137648,
U80742,
X65873, AL137283, I33392,
U67958,
AL080127, AL133113, X93495,
AL137560,
A08912, 272491, I09360, AL110197,
AL050172, AF067728, AL080159,
AL137521,
X98834, Y09972, AR038969,
I42402, E08263,
E08264, AF111112, AL133072,
E15569,
AJ012755, 561953, U68387,
I17767,
AF079763, AF1I9337, A93350,
AL133568,
I26207, AL133067, E04233,
AF026816,
AL080074, AR000496, U39656,
AL122049,
AF111849, AL137429, AF003737,
AL137526,
AL137523, Y14314, E05822,
237987,
AL137533, AL133014, AFI85576,
AL133077,
Y10655, AF162270, U58996,
AL110280,
AF000145, AL117440, U78525,
AF057300,
AF057299, I00734, AL137480,
AL133104,
AL137556, M30514, AF153205,
E00617,
417
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
E00717, E00778, Y07905, AL133081,
AJ006417, AR038854, L30117,
A90832,
AF106827, AF210052, AF061573,
AR013797,
AL137478, E08631, AF091512,
AF100931,
AL137476, U49908, X62580,
U96683,
AL137294, AL122111, A07647,
I09499,
AL133098, A45787, AF008439,
I66342,
AL137705, AF081197, A08911,
AL122118,
AL117432, L19437, AL137529,
E12747,
Y10080, X87582, AL137292,
U88966,
AF126247, AF132676, and AF061836.
HBXBG65 228 9327801 - 521 15 - 836281, AF094480, and AF094479.
535
HMVDZ78 229 9385741 - 236 15 - AB002313.
250
HE8PB92 230 12295371 - 413715 - AI879963, AI189299, AW051858,
4151 AI878977,
AI479758, AL045453, AW271337,
AW160411, AW162028, AI149405,
AI968340, AW303452, AI815661,
AW377804, AI569274, AI807283,
AI023506,
AI471357, AW369109, AW368453,
AW368509, AW368450, AI422763,
AI015868, AI799169, AI682722,
AI635546,
AL119774, AA777405, AA406166,
AA669754, AA033817, AA709153,
AA961549, H29085, T67993,
AI201745,
AI654569, AI088711, AA411138,
AA292424,
AI207055, W96116, AA029272,
AI687486,
' AI018823, AI655062, AI537447,
AI422760,
H10418, AL039715, AA782413,
AI879479,
AA291879, AI249192, AI355951,
AA972123,
AI148900, AA528040, AA007683,
AI247713,
AA524851, AW207087, AA031831,
AA126830, W96117, AA031830,
W46590,
AW132109, H10419, AA291559,
H97172,
AA182652, AW205819, AI278462,
N66629,
AA470856, AI198439, AI041366,
AA120826,
AW368514, AA460566, AA182613,
AA182762, AI699804, AA120827,
AA461491,
AW080497, AA348783, 899753,
AW043877,
AA182545, AW439115, T68139,
H02488,
AA182642, AI250641, F00043,
AA182686,
T16457, AA007684, AA009429,
W76085,
AA127312, AI631507, W72240,
AW206125,
H97171, AA182659, H02489,
AI382416,
AI908902, T28762, AI370801,
F08541,
AA182737, AI419101, F00518,
AA009430,
AA676983, AI419110, W46589,
AI419592,
AI686493, 899931, F04751,
H28980,
AA126315, AL039716, AI908897,
AI189298,
AW361233, C00266, AA854372,
AA366673,
N84974, AI961383, L24389,
M37712, and
M88565.
HSDHB12 231 9419731 - 624 15 - AA447298.
638
HE8UL90 232 9427491 - 775 15 - D80247, D80022, D51060, D80195,
789 D58283,
D80043, D80391, D59787, D80196,
D59467,
D80522, D57483, C14389, C14331,
D80439,
D80253, D80302, D59889, D80166,
D59619,
D80210, D80I64, D80240, D59859,
D59502,
C14014, AA305409, D51423,
D51799,
D59275, D80038, D80227, D80366,
D51022,
418
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
D81026, D81030, C06015, D80212,
D80219,
D80269, D80268, D80188, D80248,
D50979,
D50995, D80024, D59927, C15076,
AA514186, AA305578, D80133,
D59610,
D80193, D80045, D80157, AA514188,
T11417, AW360811, D80378,
D51103,
CI4429, AW177440, D80251,
D51759,
C75259, D80241, AW178893,
C03092,
D59653, H67866, T03269, AW377671,
AW375405, D45260, H67854,
AA809122,
AI525923, AW366296, AW 178906,
AW360844, AW360817, C05695,
AW179328,
C14227, T48593, D6b010, AW375406,
AW378534, AW179332, AW377672,
AW 179023, AW 178905, D59373,
AW 177731,
AW378528, AW178762, AWI790I9,
F13647,
AW378532, D80014, D51221,
T03116,
AW177501, C14344, AW177511,
AW352170,
D58246, AW360834, D80258,
D81111,
AI525917, AW179020, D59503,
D59317,
AW 179024, D80064, AW377676,
AW352171,
D80168, AW378533, C14973,
AW178907,
AW 178908, 233452, AW 177505,
AW 178980,
D59474, D51250, AW177733,
AI535686,
AW360841, AW352120, AI525920,
AI525227, AI557774, AA514184,
AW178775,
C14046, AW367950, AW178909,
AW177456,
C14407, C14957, AW179004,
D59551,
D58101, AW179329, AW176467,
AW178986,
AW 178914, AW 178774, AW
178754,
AW179018, AW352158, AW352117,
AI525242, D60214, AI525235,
AI557751,
AW 179009, AW 179012, C16955,
AW 178911,
AW378543, AW378525, AW378540,
AW177722, AW352163, AW177734,
AI525912, T02974, AA285331,
H67858,
AI525925, AI525215, AW378539,
AW177728, D59695, 221582,
D45273,
D80949, D59627, D51213, AW378542,
C05763, F13796, AI525222,
C04682,
AWI7878I, AW360855, C14077,
AI525237,
AI910186, C14298, D51053,
AI905856,
T02868, AW369651, 230160,
C13958,
AI525928, D80314, AA305720,
D51231,
D31458, D50981, N66429, AI525228,
AI525216, AW177508, AW177497,
T03048,
AI525238, AI535961, AI535959,
AF154671,
A62300, AF058696, AR018138,
AB002449,
A82595, AR060385, A84916,
A62298,
AB028859, AJ132110, AR008278,
I50I26,
I50132, I50128, I50133, AR054175,
AR016514, I14842, X67155,
AR060138,
A45456, Y17188, A94995, D26022,
A266I5,
AR052274, Y12724, A25909,
AR066488,
Y17187, Y09669, A43192, A43190,
AR038669, A67220, D89785,
A78862,
D34614, AR008443, AR066487,
A30438,
A63261, AR008277, AR008281,
AR062872,
A70867, D88547, AR016691,
AR016690,
419
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
U46128, D50010, AR008408,
A64136,
A68321, X82626, I79511, X68127,
D13509,
AR025207, AR060133, AF123263,
X72378,
and AR032065.
HTXAA15 233 12004851 - 2541 15 - AA814365, AA648502, H11953,
2555 820002,
AA746117, H06599, AA374468,
and
W60570.
HOFMP09 234 11948401 - 1346 15 -1360AI096506, AI688979, AW088625,
AI623455,
AI378021, AW089731, AI334787,
AW 148926, 854862, AI744763,
AW 102888,
AW072414, AI061201, 854001,
N59116,
T53386, 852267, AI565144,
AA477654,
AI886419, AW089470, AI804837,
AA402646,
853118, AI887407, AI830659,
AA479843,
AI65379I, AA394269, AW19389I,
AI684263,
AI499132, AI887289, AW194324,
AA291585,
H24954, AI432124, 873552,
AI653885,
AI873571, AA633384, AW150649,
AI870177,
AW028475, AI873999, AI538811,
AI524776,
AW243859, AI684209, AI525964,
847936,
AA476975, AW103389, AI288000,
AA430383, AA410602, AA293640,
AW 130914, AI914715, AA236709,
AW439076,.AI538248, AA479720"AI524589,
AA411455, AA477340, AW338545,
AW438957, AI283299, AI689706,
AA426533,
AA757345, AI241778, AA428332,
AA290786,
AA430560, AI918551, AI345347,
AI345416,
AI345612, AI345415, AI648684,
AI591415,
AW129264, AI280561, AI859464,
AW 105601, AA464646, AI801602,
AA433977, AI587606, AI682798,
AI784028,
AI865320, AI468872, AI280661,
AI699011,
AA367777, AI583054, AI610645,
AI439443,
AA804614, AI539153, AW 161202,
AW450212, AL039086, AI677797,
AW102900, AA743354, AI874151,
H92687,
AI886055, AW268122, AI633419,
AL041115,
AI270099, AW198075, AW020419,
AI610667, AW082532, AI800464,
AI494201,
AI886594, AI680498, AI537617,
AW089006,
AW409775, AI570966, AI554343,
AW163823, AA768725, AI805688,
N27632,
AL038445, AW168503, AA761557,
AW021091, AI872148, AI590118,
AI919593,
AI744768, AI678446, AW275299,
AL039276,
H89138, AI636619, AI863665,
AI696819,
AI680280, AW088899, AW020397,
AI336575, AW 193467, 841605,
AA568405,
AW029533, AW169604, AW193125,
F37471,
AW089275, AA580663, AI287446,
AI537075,
AL040011, AW085786, AI475270,
AW265004, AL079728, AW 151034,
AW023338, AI568138, AI955945,
AI345477,
AI285448, AI254226, AL119791,
AI624529,
AI918554, AI078510, AA603709,
AI916419,
AI348914, AI921442, AI419650,
AI335426,
AI348777, AI631107, AW051088,
N71180,
AW083750, AI917963, AI961589,
AI288285,
420
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI766348, AA744557, AI890507,
AI690748,
AW059828, AI630927, AL037582,
AW194441, N75771, AL037602,
AI251221,
AI279628, AI744279, AI873638,
AW162189,
AI348901, AW026630, AI345688,
AI933992,
AW084097, AI866820, AI684145,
AA493923,
AI365256, AI857296, AW151136,
AI868163,
AI56I356, AA494167, AW263808,
AI559599,
AI538850, AW163834, AL119399,
AI345608,
AL040243, X83425, AF221507,
AF158248,
AL137555, AL080127, AR029490,
AFl 13676,
E03348, AL137557, E03349,
U91329,
AL050024, X06146, 282022,
AL050138,
AL110171, AL049466, X63162,
AL122098,
AL133014, AL050277, AF176651,
A18777,
AL049452, A08916, AR068751,
AC002467,
AF036941, I89947, I48978,
A08913, E01314,
AR038854, AF047716, 577771,
A08912,
A08910, I89931, A08909, Y11587,
AL133619,
E01614, E13364, I49625, AF118094,
A65341,
AF162270, AL110196, A08908,
AF199027,
AJ242859, U96683, Y10080,
E02221, S76508,
AF113689, AR038969, AF113699,
U90884,
AR059958, AB007812, AL117629,
AL117440, I89934, AF100931,
X93495,
ALI33104, X79812, AF118070,
Y11254,
AL137478, E01812, AL050172,
AF082324,
AF026124, AF061795, AF151685,
AL133016,
AL137658, AL137527, AL117432,
AL110222,
AL137521, AL137665, AJ012755,
U72620,
X72889, AF003737, L30117,
Y08769,
AL122118, AL133072, U95114,
U92068,
X00861, U49434, AF090886,
AF061573,
ALI37300, AR013797, AL1I7583,
U87620,
X83508, AF169154, AF028823,
A65340,
AL133640, E06743, AL110221,
AL117578,
569510, S68736, AF146568,
AL133565,
I89944, AL080159, A08907,
E04233,
AF065135, AL122106, I17544,
AL137273,
AF106657, AF030513, AL080074,
AL049300,
AF111851, D83989, U77594,
AF185576,
AL050155, E15569, AF067790,
AL049460,
AL133645, I03321, AL050116,
AF058921,
AF125949, AL137550, AL050170,
X70514,
AL137537, A15345, AF026816,
AL080124,
A21103, AL122110, 575997,
536676,
AR000496, I33392, U39656,
I42402,
AL117649, J05032, AL133075,
I09499,
AL137256, AL137547, A12297,
AL137480,
AB029065, AL080163, AL122121,
AF032666,
AL110280, AL137476, X53587,
AL137459,
L19437, X70685, AF215669,
AL133080,
X98834, AL137574, Y14314,
AR059883,
AF205861, AL023657, AF061981,
U78525,
AL080148, AF139986, AL096751,
AL137548,
AF102578, AF057300, AF057299,
AF017437,
X80340, AF017790, X92070,
237987, I30339,
I30334, AL133606, I68732,
AL137463,
AL080060, A52563, AL1I7648,
X72387,
421
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL117416, AFI53205, AF094480,
A45787,
D16301, AL050092, AF137367,
AF000145,
AF081197, AF081195, AF113013,
E01573,
E02319, AF111112, AF078844,
U42031,
AF091084, AL137429, AF110329,
AF114170,
AF126247, AL137526, AF118064,
AF183393,
X52128, AL133624, AL137538,
AL080234,
AL080158, AF000301, AL137711,
AL137292,
I48979, AL049465, U88966,
A08911, I22272,
561953, X63410, AR020905,
Y16258,
AF113019, X82434, U54559,
and AL122049.
HFPEL47 235 11433881 - 196315 - AJ243874, and AL031575.
1977
HFIHF63 236 1137853I - 202915 - AI127432, AA010826, AAI47500,
2043 AI127523,
W95509, AW182823, AI383344,
AA625557,
AI420515, AI378016, AI669104,
AA147929,
AA234759, AI864152, AW297177,
W954I2,
AA011202, AA782437, AI869000,
AI702739,
AI027151, C02468, AA889785,
AA450119,
and AI291551.
HCElI41 237 11562271 - 214515 - AI769814, AI332304, AI43S407,
2159 AI568859,
AA716223, H23117, AI470931,
AI769160,
H23116, T15752, T16288, 871701,
819556,
T33015, 843906, T27055, AA077185,
AA223802, AA349536, AA224351,
and
AC008039.
HHAUD86 238 1195748I - 1912IS - AA477213, AA929049, AI246790,
1926 AI817726,
AA477264, AI090213, AI040006,
AI625881,
AA327819, AI042113, AI624098,
AI653458,
AI887475, AI751773, AW264080,
AI758930,
AI796494, AI146845, N26216,
AI796630,
AI039881, F30814, AI688562,
AI278769,
AI751774, AI082861, W73303,
AI185324,
D63205, AI081463, AA115144,
AI660724,
AA775566, AI368115, W73038,
AI401254,
AA775270, AA334737, AI089662,
AA776836,
AA804859, AA775860, AI039841,
AI910517,
AA774463, F36581, W45177,
AI129600,
AI246469, 870622, AI3999I6,
AI750917,
872411, AI217429, AA769804,
AA421770,
AI468412, 870456, H39900,
870522,
AA852390, AW439978, AA039500,
AW028386, AI127154, AII22975,
873276,
AI081861, AA530998, AA992235,
872825,
872450, 869467, W92952, AI927256,
AA037484, W16559, AA115367,
AI092399,
W45082, W92953, AI263350,
AA908436,
AA568530, AA037563, AI184469,
AW273646, 848676, AA039499,
AI244856,
AA129903, AA129904, AW439903,
AA644176, AA853860, AI042566,
AI016097,
AI494579, AA776612, AI904995,
AW 170175,
AA733145, AI201332, AI608936,
AI632408,
AI886753, AI819976, AI584140,
AI280637,
AI702433, AI491897, AI818980,
AI382201,
AI434468, AL036I46, AI54I056,
AW149869,
AW081036, AW198068, AI269205,
AI620003, AI679174, AW150453,
AI800384,
AI624206, AI637584, AI538716,
AI611738,
AI559296, AI955917, AI862139,
AW132056,
422
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI696612, AI274508, AI890833,
AI926790,
AI564719, AI281772, AI889376,
AI620284,
AI524671, AI926367, AW051258,
AI921248,
AI619502, AI677796, AI802542,
AI933589,
AW026882, AI433157, AI702073,
AI796743,
AI866751, AL079963, AI475394,
AW079075,
AI633125, AI446373, AW008048,
AI872545,
AI439350, AW104724, AI431975,
AL119863,
AW117746, AI866780, AI499285,
AI783504,
AI349004, AI362637, AW118518,
AA279293,
AW268220, AW080327, AI872711,
AW080090, AI567935, AI493248,
AI648509,
AI286256, AI634751, AW301505,
AI590227,
AL045500, AI345587, AI289937,
AI922215,
AL045266, AL039086, AI499381,
AI287489,
AI537244, AI816010, AW 149227,
AI476046,
AI554485, AI491775, AI345416,
AI345612,
AI627360, AI818977, AA508692,
AI873644,
AI611354, AI687728, AI934259,
AI432969,
AI682841, AI280521, AI521040,
AI445432,
AI476109, AI815232, AI435641,
AW198090,
AI335426, AI348777, AW166903,
AL036802,
AI554818, AI610307, AI801325,
AW002362,
AI500523, AL121286, AI932794,
AW103371,
AI702068, AW086113, AI285735,
AI536638,
AI306613, AW183130, AI521560,
AI922901,
AI569583, AI500662, AI623396,
AI619749,
AI932510, AI284484, AL047763,
AI634737,
AI254731, AI538829, AI439443,
AW076093,
AW 104827, AI445025, AL050202,
X82434,
I89947, AL117435, I48979,
A08913,
AF090934, AF091084, AL080124,
AF113677,
I48978, A08916, X84990, AF090903,
A08910,
I89931, AL137550, I49625,
AF183393,
AL049382, AJ000937, AL133640,
282022,
E02349, AL133075, AF090901,
Y11254,
AL110196, AL117460, AL133560,
AF090900,
AF158248, AL050149, X63574,
E03348,
AF113691, AL133016, AL133113,
AF113690,
I03321, AL050393, AL050277,
AF113699,
E07108, AR059958, AL049938,
A65341,
AF017437, AL133093, A77033,
A77035,
AL110221, AL117457, AF177401,
AF113019,
Y11587, A08909, AL050108,
AL049452,
AL137271, AL080060, AL122121,
AR011880,
578214, AL049466, AF106862,
AF104032,
AL050116, AF125948, AB019565,
AF113694,
Y16645, AL137557, AL133080,
AL117583,
AF090896, AF079765, A58524,
A58523,
AJ238278, AF113676, AL110225,
AF113689,
AF146568, AL133565, AL050138,
AL049464,
AF113013, 568736, AF078844,
AF111851,
AL137459, AJ242859, Y14314,
AL122093,
U42766, AF090943, AF118064,
AF118070,
AL049314, AL117585, AL133557,
AF017152,
AF125949, AL122050, L31396,
AL050146,
AL080137, AL117394, AL137527,
AL133606,
L31397, AL122123, E07361,
A93016,
AL050024, I33392, AL049300,
AF118094,
423
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL137463, AF087943, A03736,
X72889,
AL049283, AL122098, AL096744,
U35846,
U91329, AL049430, U00763,
A08912,
AL137283, AL122110, AL137538,
U80742,
A12297, AF097996, X70685,
AL080159,
U72620, AL137648, AF026816,
X98834,
X96540, X65873, AL080127,
X93495,
AL110197, AF061943, AF067728,
AJ012755,
U67958, AL137560, I09360,
A93350,
AR000496, U39656, I42402,
AL137521,
E08263, E08264, AL133072,
E15569,
AL110280, AR038969, AF111112,
AF119337,
AR038854, AL137523, I26207,
AF153205,
AL133014, AF079763, AL133568,
AL050172,
AF185576, AF026124, A45787,
Y09972,
AL133077, AF057300, AF057299,
AF000145,
Y07905, AL137480, AL122049,
AL137533,
AL133104, 237987, A08911,
AL137556,
AL137526, AF111849, AJ006417,
AL137476,
E05822, AL122111, AF106827,
AL133098,
AF003737, AL080074, I17767,
I00734,
561953, E00617, E00717, E00778,
272491,
A07647, U58996, AL133067,
L19437,
AL117440, AF030513, U88966,
X87582,
AF162270, I66342, AL137705,
AC006371,
AL137294, U68387, AF061573,
AF008439,
M30514, U96683, AL137292,
U49908,
AL137478, AF118090, Y10655,
E04233,
L30117, AF051325, A90832,
E08631,
AL023657, AL080148, AR013797,
AF069506,
D83032, AF095901, AL137429,
AF132676,
AF061836, AF061981, E12747,
X83508,
AL133081, and AL122118.
HFKKE19 239 9474181 - 276 15 - D87469, AL031597, AL157901,
290 and
AL356389.
HLWAR77 240 9474841 - 1275 15 - AA449919, AA449920, and AF119815.
1289
HWAFW39 241 12177871 - 3297 15 - AA694391, 807065, T27258,
3311 AA397568,
AI382296, AA399529, AA996049,
AL120058,
807488, AA569667, AA582073,
AA507822,
AI056177, AA581247, AA452887,
AI251591,
AA604645, AL079734, AA084609,
AI829174,
AI254913, AA579205, AA524229,
AA630854,
AA837686, N32944, AA701080,
AI280504,
AI291309, AA228778, C15363,
F28845,
AA508809, AI783911, AA744018,
AA714288,
T41115, AI254779, AA213959,
AL119247,
H58354, AI370512, AI419337,
AA503018,
AW 188742, AA584862, T39169,
AA557982,
AA659324, AA845848, AA558814,
AI440117,
AW265279, AI049676, AA665181,
AI361900,
AA904275, AA904137, N64587,
AA019804,
W45306, AA018207, AW023662,
AA828592,
AW302017, H96249, AA829036,
H11612,
AI569363, AA715173, AA114077,
AA715075,
AA598954, F08248, AF106037,
AF222340,
AB011097, AF183569, AC005519,
U91321,
AC004655, AC005004, AC000087,
AC006581, AL031587, AP000555,
AP000493,
AP000967, AL022721, 293023,
AC004150,
424
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AL022238, AC007999, AC003665,
AC004707, AC005017, AC006965,
AC004910, AC004685, AL049569,
AL035683, AF111168, AL049757,
AC006013,
AC010200, U47924, AC005778,
AL031295,
AL035400, AF200465, AC005726,
AC016831,
298742, AC005874, AF134471,
AC003104,
AC007298, AL031255, 282244,
AC005003,
AL035455, U80017, AC004878,
AC009516,
AC002316, AC004583, AL049869,
AL009181, AC004098, 296074,
AC002558,
AC005740, AC009731, AC005934,
AC004921, AC005242, AC006953,
AC007021, AC003101, AF001550,
AC002425, AC005031, AL031848,
U52112,
AL023807, AC000025, AF001548,
AF091512,
AC007938, 293930, AC004953,
AC005495,
AC007216, AC005527, AC006597,
AP000045, AL035685, AC006538,
AP000117,
AL132992, AC005049, 284487,
AL096701,
U85195, AL121658, AC000026,
297054;
AP000252, AC005523, AL049766,
284466,
AC002301, AL035079, AC004832,
AD000092, U91326, AC005632,
AC004966,
AC005900, AL096791, AC003684,
AC016025, AF129756, AC005940,
AL022163,
AC012384, AP000079, AC002544,
AC005037, AC006039, AC005952,
AC007371, AF024533, AE000658,
AC007227,
AL034420, AC004099, AC005899,
AC016830, 297053, AC004675,
294044,
295113, AP000350, AC006285,
AL022165,
AC005207, AC005102, AF038458,
AC004895, AC005606, AC004797,
AC004448, AL035684, AC002350,
AF088219,
AC005411, AC004386, AC004596,
AC007637, AL117258, AP000553,
AF001549,
AL109827, AC007541, AP000692,
U62317,
AC003689, AC009509, AL133355,
AC005702, AF196969, AC005839,
AC004000, AC004821, AP000115,
U07562,
AC005391, AL031602, AL034423,
AC006537, AL020997, AC007193,
AL117354, AC005920, AL0967I2,
AP000558,
AC004815, AC004841, AC002300,
AC005041, AL035555, AC006312,
AC002044, AC000090, AC005091,
299716,
AJ003147, AD000812, 293017,
AC002365,
AP000247, AC005544, AL031276,
AP000112,
AC002314, AC005104, AP000704,
AL050321,
AC005514, 298941, AL009172,
AC005387,
AL050332, AP000689, 285996,
AC007687,
AL024498, AC002299, AC005875,
AC002126, AJ011930, AL133312,
AC004104,
AF205588, 294056, AC002115,
AC004876,
AC004805, AC004859, AL050318,
AC004485, AL133289, AC005844,
AP000697,
AP000313, U95742, AC007546,
AC005747,
AL035072, AL035411, AC002511,
AL021391,
425
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
U89335, AC007308, AC002059,
282178,
AL031774, AC005482, AC003982,
286090,
AC006014, AC007226, AC00657I,
AC004383, 295118, AL031597,
AC005666,
AL022336, AL080243, AP000152,
298044,
AC003036, and AC005881.
HBCBF1I 242 12049331 - 193415 - 867750, AWI18248, HI2807,
1948 866136,
AI016321, N47721, AI866708,
AA148713,
AC005015, AC005081, AC005049,
AC005264, AC004526, AC003101,
AC002288, AC006512, AC004895,
AC004953, AC004638, AF049895,
297054,
AF030876, AC018633, AC007842,
AL031728,
AC005829, AL121748, 269732,
295115,
AF031078, AC005222, AL034412,
AC006449,
AC006965, AC004612, U47924,
AC006362,
AL031311, AC005841, AC006344,
AC003684, AC004834, 295116,
AL009172,
AC007298, AC007157, AC005913,
AC006530, 285987, AL109627,
AC005828,
AC007687, AC006946, AC005736,
299128,
AC004601, AL049795, AC005924,
AC007685, AL035410, and ALi
17352.
HHFME38 243 947970I - 629 15 - AC004616, AC011307, AC011307,
643
AC004616, AC011302, and AC011302.
HBJHS02 244 11561661 - 163015 - AW205367, AW402801, N24246,
1644 AI654541,
N28316, N38941, AW383418,
AW383426,
AI276242, AA215300, N33010,
AW383396,
AA458944, N20230, AI439520,
AW402242,
W03476, N25452, AA459158,
AW383428,
N30453, N21241, AI760983,
N20533,
N73074, AI434284, N72999,
N20563,
AW403946, N67502, AI470743,
AA837208,
AW407871, H84381, AW404443,
N29316,
N26470, AI864746, H98912,
H84382,
N35519, H99497, W02963, AW403434,
W02298, N4651 I, AA76I778,
N71796,
AI222330, N29315, AW402824,
N28949, and
AW402928.
HCE3J64 245 12166501 - 165215 - ~AI951872, AW305020, 838978,
1666 AI094942,
AA448371, AA448777, H46357,
AW341249,
ABOI 1176, and U27341.
HFKHD91 246 11296271 - 134915 - AI858128, AA422028, W74456,
1363 AI524577,
W79191, and AB023193.
HDAAN31 247 12049791 - 174415 - AA620978, AI419965, AI635561,
1758 AI695908,
AI123457, AA927259, AA489964,
AA401729,
AW 104724, AL036146, AI269205,
AI432969,
AW 132034, AW 151485, AW008048,
AI673710, AI274541, AW087445,
AI349937,
AI580984, AI445025, AI538829,
AW149869,
AI536638, AI783504, AI620284,
AI68284I,
AI637584, AI5387I6, AI802542,
AI564719,
AI758437, AL036396, AW074993,
AI349614,
AI524671, AI343112, AI349645,
AI619502,
AW268253, AI349598, AI312152,
AW026882, AI345735, AI281762,
AI307708,
AI433157, AI349772, AA508692,
AI500523,
AI349004, AI284484, AW071417,
AI627360,
AI538259, AI625079, AL044207,
AI590128,
426
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AW169671, AI340582, AL045500,
AL119049,
AI282281, AI636456, AL047763,
AI634737,
AI554818, AW071349, AI800453,
AI800433,
AI271786, AI440239, AI683585,
AI872711,
AI590227, AI871697, AI568855,
AI648684,
AI309401, AI635461, AI624206,
AL036361,
AI439717, AI925196, AI349256,
AI815855,
AI926790, AI869367, AI349933,
AW268220,
AW 103371, AI521012, AI281837,
AI921248,
AI334884, AI348897, AW 183130,
AL040243,
AI445432, AI273142, AI345253,
AW30I409,
AL047042, AI702073, AI290154,
AW 169653,
AI249323, AI567612, AL042753,
AL036802,
AI560099, AW075413, AI673297,
AI284020,
AI800384, AI678302, AW129171,
AI597750,
AI568870, AI630928, AI499463,
AW090013,
AW274192, AI249257, AL045266,
AL043326,
AI636445, AW 118512, AW 131954,
AW196141, AI612920, AI554484,
AI538790,
AI283941, AL135661, AI610756,
AI811344,
AI912866, AI275175, AI702406,
AI281779,
AI570384, AI857296, AW002342,
AI440426,
AI475451, AI569616, AI702433,
AI224992,
AI799199, AI572787, AW075351,
AI686877,
AI687728, AI349226, AI269696,
AW 148320,
AI868831, AL038605, AI500077,
AI633419,
AI498579, AI445165, AI866002,
AI433976,
AI922901, AI828731, AI281773,
AI567128,
AW117882, AW087462, AI610645,
AI567351, AI697137, AW238730,
AL038565,
AI609593, AW080327, AI862144,
AI631107,
AI636719, AI539153, AW150578,
AW168650, AI539771, AL134259,
AI950664,
AI866608, AW089572, AI349957,
AW195969, AW086113, AI500659,
AI612913, AI475371, AW068845,
AI609331,
AW026610, AA804740, AW005858,
AW075667, AI539780, AW074869,
AI754897, AI828682, AW301300,
AL036274,
AW 148408, AI521040, AI610307,
AI591311,
AI920968, AW075207, AI287489,
AI250293,
AW129202, AW102761, AW118557,
AI702068, AI818683, AI634345,
AI499393,
AI160954, AW149851, AW403717,
AI690426, AI564992, AI571909,
AI285735,
AL119791, AI812107, AI569583,
AI554427,
AW082040, AI889376, AI537303,
AI784252,
AI687127, AA287231, AI537677,
AI690480,
AI609589, AL036631, AI687375,
AW080992,
AW188539, AI570009, AI668893,
AI431327,
AI064830, AC007023, AL050393,
AL122093,
I48979, I89947, AL050108,
X84990,
AL080124, AF113694, AL080060,
AF106862,
AL133640, I8993I, AF090900,
568736,
AF090901, AF090903, S78214,
A08916,
A08913, AF118064, AF113677,
AF113691,
AF113019, AF090934, AF113699,
AL133016,
I48978, AL117457, AF090943,
AF078844,
L31396, L31397, AL133557,
AL117460,
427
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AF090896, AL110221, AL050116,
AL137527,
AL110196, AB019565, AF113690,
AL122121,
AF104032, AL049452, AJ242859,
AL133075,
AL050146, AF113689, AF113013,
Y11587,
E03348, AR059958, U42766,
AF118070,
AL122050, AL049314, AF017152,
AL050149,
AF125949, AL080137, AL133606,
X63574,
AL049466, AL049938, AL050277,
AF113676,
AL133093, AF158248, AL133565,
A93016,
Y16645, E07361, AL133080,
AL137557,
AL050138, AF111851, AL122123,
AF091084,
AJ000937, AL117394, AL137283,
Y11254,
X82434, AL137459, AL096744,
AF125948,
AL110225, AF079765, AF146568,
A65341,
U91329, I49625, AF017437,
A03736,
AL133560, E02349, U00763,
AF177401,
AL049430, AL137550, AR011880,
AJ238278,
A08910, A08912, AL117585,
AF097996,
X70685, AL049464, AL117583,
282022,
E07108, AL049300, AL117435,
A12297,
AL049382, A08909, AF067728,
AF183393,
. A77033, A77035, AL137271,
A58524,
A58523, AF118094, I33392,
AL050024,
AL137648, AL133113, I03321,
X96540,
AL049283, AL122098, AL122110,
X65873,
X72889, AL137538, AL137463,
U80742,
U35846, X98834, I09360, AF087943,
U72620,
Y09972, S61953, AC006336,
AL080159,
AL080127, AL110197, AL133568,
U68387,
X93495, AJ012755, U67958,
U49908,
AL137523, AF111112, AF026816,
AL050172,
I42402, AL137521, I66342,
E08263, E08264,
AL137560, AL133072, AF061943,
AR000496,
U39656, E15569, A93350, A08911,
AF057300, AF057299, II7767,
A07647,
AR038969, AF119337, AF003737,
AF095901,
X87582, AC004690, AC004093,
AF026124,
237987, M30514, AF118090,
I00734, Y14314,
U95739, I26207, E00617, E00717,
E00778,
Y07905, AL110280, AL133104,
AF185576,
AL137526, AF106827, L30117,
AR013797,
AL133077, AL122049, AL133098,
AC007390,
AL133067, AR038854, E05822,
272491,
AF153205, A45787, AL133014,
AC004200,
L13297, U58996, AL122111,
AF079763,
AF100931, AF162270, AC004987,
AC002467,
AR054984, U78525, AL137294,
AF000145,
AL137556, AC004686, AL137429,
AL137292,
AC006371, AL137533, AL117440,
AL137476,
A90832, AL080074, L19437,
AL035587,
AF061573, AC007298, X62580,
and
AF111849.
HE8AM92 248 11627791 - 194815 - AW195380, N23786, AI807492,
1962 AI734217,
AA425224, AA634119, AI088774,
AI668657,
AI805290, AI693531, W20302,
AI344107,
AI830204, AA071290, AI023328,
AW069189,
AI446315, AI764987, AI367900,
AI088165,
AA541267, AA779556, AA228107,
AI040754,
AA521303, AA552601, AA314127,
854083,
428
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AI263054, H29680, AA046045,
AI870566,
AA122313, AI921148, AA815201,
AA884602,
860682, AA747446, AW297058,
H08571,
AI361541, 860683, AI284342,
T66056,
AA873444, AA122312, D52689,
AA386170,
AA399256, AW242164, 819696,
818168,
F13183, 243231, AI093433,
N36074, T77025,
AA151813, T65297, AA350782,
AI309309,
AA576719, 854134, D25599,
AW004629,
N46213, 836565, AI620774,
T33549,
AA8114S4, C20572, AA337811,
812223,
F02683, F10790, AI421110,
F03793, F12174,
834437, AA888883, AI289652,
AA279402,
AW105294, F07164, F08075,
AI355753,
H29594, AA328526, T36239,
AA975250,
850027, F06393, F11810, 840964,
839944,
848971, 841712, N36942, F07553,
AI244963,
AA642020, AW367327, AI354930,
AI092767,
AW008997, 844252, 850366,
AI335889,
AI460092, AI766428, AA806386,
AA334776,
AI358493, AA331654, AA774074,
824870,
F05321, F05907, AA577350,
AI569329,
AI273806, AI358182, F03445,
F05235,
844573, F05322, N69072, F01488,
AA902193, AI284343, AA046154,
D61303,
AI335808, AI022959, F05267,
AW069641,
814569, AI471308, F01581,
T24915,
AA425500, T2S071, AI283001,
AA071293,
AA984503, F02156, AA748545,
T31990,
F01582, F01520, AI699076,
858045,
AA412231, N90680, T10067,
AA169608,
AW371978, AJ243721, AF182814,
AI637725,
AW510545, and AW518221.
HSXBF22 249 9527441 - 162615 - AI973128, AI459802, AI370911,
1640 AI370927, 3
AI423465, AW207527, AI873583,
888039,
886664, AI356884, AW015789,
AI460086,
N46716, AI886914, and H43809.
HUSXE73 250 11258451 - 212615 - AW 138763, AI968244, AI671228,
2140 AI146849,
AL037051, AI650986, AL042909,
AL040992,
AL039423, AL038531, AA974891,
AL039109, AL045353, AL036973,
AL039128,
AL045337, AL038837, AI93S406,
AI375139,
AL045341, AI632343, AL038025,
AL044407,
AL039074, AL039108, AL039386,
AL039659,
AL037726, AL039648, AL039625,
AL039678,
AI580312, AL039629, AI1903S8,
AI823383,
AL039564, AL039538, AA758662,
~
AW166381, AI816934,
AI362170, AI307616,
AL039410, AI339511, AL037639,
AI092493,
AI193719, AA676785, AL039566,
AL036196,
AL037615, AL044530, AA701414,
AI375073,
AI077483, AL039509, AI090245,
AW003931,
AL036767, AL039156, AI307365,
N70081,
AL036238, AL037027, AI991601,
AL036765,
AI967935, AL043441, AI637874,
AI990350,
AI825545, AI621021, W67234,
AL036725,
AL0361S8, AI186726, AW206481,
AW140070, N30322, AL039150,
AL036117,
AL037601, AL039924, AW338117,
AI095704,
429
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
AA031644, AI859068, AW136394,
H00954,
AW263085, AL036132, AI984849,
AW338430, 839467, AI219050,
AI334231,
862632, AI241351, AL036167,
AI355851,
AI334036, AL037047, AL038821,
AA449686,
AL036964, AI336416, H72039,
AI735518,
AL037054, AL037643, AL037085,
AL045794,
AL036679, T24119, AA699736,
AL039085,
AL037021, T24112, AL037177,
AL134524,
AW013814, AL043445, AL037104,
AL038043, AL043422, AL037526,
AL039076,
AL037049, AL037600, AL043423,
AL036924,
AL036268, AL036133, 839468,
H00069,
F26300, AL036163, 830863,
AL036733,
AL036914, AI130689, AL043868,
W67345,
AL037742, AL036139, AL036207,
AL036418,
AI142134, T23947, AL036998,
AL038983,
T02921, AL036900, AL042898,
AL037124,
AW451070, AI905981, AL036152,
AI906040,
AI906064, AL037082, AL038851,
AL037727,
AL037178, AL045328, AL036190,
AL039643,
AI535983, AL036228, AI620138,
AI535783,
299396, AL036191, AL049018,
AA358091,
AW452756, AL038838, AL037436,
AL036742, N74688, AL036150,
AA704504,
AL047012, AL037323, AL044125,
AL047170,
AL040463, AI524317, 847228,
AL037435,
AL047219, AL039432, AL044162,
AL041238,
AL038532, AL040193, AI183860,
AL040621,
AL043538, AL043496, AL040464,
AI801924,
AL041347, AL038822, AL047183,
AL041324,
AL041098, AL039077, AL044186,
AL037295,
AL040617, AL041096, AL040625,
AL044037,
AL038761, AL041163, AL048425,
AL040510,
AL043923, AL043814, AL045684,
AL040075,
AL043467, AL043845, AL044603,
AL041133,
AL040576, AL041752, AL041635,
AL047057,
AL040294, AL036953, AL040119,
AL041358,
AL043677, AL045753, AL040322,
AL041296,
AL044064, AL047037, AL040839,
AL041459,
AL040472, AL041577, AL040149,
AL043492,
AL041602, AL041346, AL042135,
AL041086,
AF186111, A10361, E13740,
I13349, A35536,
A35537, A02135, A02136, A04663,
A04664,
I08051, A91965, I19517, A22413,
A76773,
A11245, A92636, AR035975,
AR035977,
AR036903, AR035974, AR035976,
AR035978, AR027069, AR062871,
A04710,
AR017907, A95051, A02712,
AR062872,
I06859, A18050, A23334, A75888,
I70384,
AR062873, A60111, A23633,
AR007512,
A52326, A18053, A43189, A43188,
A20701,
V00745, AR043601, A20702,
A84772,
A20700, A84776, A84773, A84775,
A92133,
A84774, AR067731, AR067732,
A91750,
A58522, I60241, I60242, A02710,
E12615,
AR035193, A07700, A13392,
A13393,
AR027100, I28266, I21869,
X73004, A70040,
E03165, AR060673, AR060676,
A49428,
430
CA 02395858 2002-06-21
WO 01/54474 PCT/USO1/01349
296142, AR028564, A08458,
A08457,
E02221, E01614, E13364, A51384,
I01992,
A00782, A02741, A14595, A18755,
A25856,
I12245, A13038, A29289, A49695,
A49696,
AF118808, I66498, I66497,
I66496, I66486,
X68127, I40851, A60983, AR022240,
AR031374, A49700, AR031375,
A58521,
AR020969, AR025207, AR036905,
A38214,
A44171, I56772, I95540, AR018924,
A63067,
A51047, A63064, AR018923,
A48774,
A63072, A48775, AR068507,
AR068506,
AR015960, AR000007, AR015961,
A85477,
A85396, AJ244003, AJ244004,
A25909,
I66495, I66494, A98767, I19516,
A93963,
A93964, I63120, A95052, AR043602,
AR043603, A95117, A23998,
I66487,
AR037157, A86792, AR054109,
I18371,
A58524, A58523, A64081, A24783,
A24782,
A81878, I03343, E14304, A27396,
A97211,
A49045, E16678, E16636, A82653,
A93016,
U87250, D28584, I25027, I26929,144515,
I26928, I26930, I26927, A58525,
I49890,
I44516, AF156296, AR038762,
AR000006,
A58526, A91753, I00079, E
16590, I84554,
I84553, AF156294, AR064707,
AJ244005,
AJ230933, Y11923, A67220,
Y11926,
A15078, I00074, I03665, D88984,
I03664,
X16234, E00523, AR038286,
I25041, I92483,
I00077, AR008430, AF156303,
DI4548,
AR066494, AF156299, I07429,
I18302,
M28262, X13220, D34614, A97221,
AF156302, AF156304, AF019720,
S70644,
A18722, A91754, E06034, M32676,
AB012117, I69350, AF096810,
AR063812,
565373, X58217, E04616, AR064706,
I68636,
A60957, I62368, AR031488,
I13521, I52048,
I44531, A60968,105558, Y11449,
AF096793,
AR066482, A60985, A60990,
A60987, I48927,
AR009151, D44443, I66485,
874316,
AI433512, AI634964, AI933476,
and
AI933484.
HNFCS26 251 8994061 - 168715 - H70763, AW376414, AW403498,
1701 AW205281,
AW204171, AW450761, AI571894,
AF114491, AC004262, AC005327,
AC004999, AF053356, AC004841,
AL021707,
AC003010, AC004834, AC007151,
M22403,
AC007663, and AL034400.
HWLXT48 252 9576301 - 440 15 - AA932449, AA306873, AA305881,
454
AW245862, AA088641, N44651,
N31513,
825850, 888663, AW248398,
AI073401,
AA137171, AW449148, AI824292,
AL136295, and AF044127.
HBCPT10 253 9576311 - 127815 - AI131178, AI073401, AI087304,
1292 AW001150,
AI870504, AA632131, AA527353,
AI268314,
AI199367, AI279I89, AW4I919I,
AA293I61,
AA639837, AI859436, AA777588,
AI936230,
AW071823, AA809698, AA528107,
W72175,
AA719229, AA809330, AI333884,
AI138637,
AI202785, N33080, AI299098,
AA527330,
431
DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.
CECI EST LE TOME 1 DE 3
~~ TTENANT LES PAGES 512 A 431
NOTE : Pour les tomes additionels, veuillez contacter 1e Bureau canadien des
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