NOVEL POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME

NOUVEAUX POLYPEPTIDES ET ACIDES NUCLEIQUES LES CODANT

English Abstract

The present invention is directed to novel polypeptides and to nucleic acid
molecules encoding
those polypeptides. Also provided herein are vectors and host cells comprising
those nucleic acid
sequences, chimeric polypeptide molecules comprising the polypeptides of the
present invention
fused to heterologous polypeptide sequences, antibodies which bind to the
polypeptides of the
present invention and to methods for producing the polypeptides of the present
invention.

Claims

WHAT IS CLAIMED IS:

1. Isolated nucleic acid having at least 80% sequence identity to a nucleotide
sequence that encodes a polypeptide comprising the amino acid sequence shown
in Figure 45
(SEQ ID NO:119).

2. The nucleic acid of Claim 1, wherein said nucleotide sequence comprises the
nucleotide sequence shown in Figure 44 (SEQ ID NO:118).

3. The nucleic acid of Claim 1 or Claim 2, wherein said nucleotide sequence
comprises the full-length coding sequence from within the sequence shown in
Figure 44 (SEQ ID
NO:118).

4. The nucleic acid of Claim 1 which comprises the full-length coding sequence
of
the DNA deposited under accession number ATCC 209670.

5. Isolated nucleic acid having a nucleotide sequence that encodes a
polypeptide
comprising the amino acid sequence shown in Figure 45 (SEQ ID NO:119).

6. The nucleic acid of Claim 5, wherein said nucleotide sequence comprises the
nucleotide sequence shown in Figure 44 (SEQ ID NO:118).

7. The nucleic acid of Claim 5 or Claim 6, wherein said nucleotide sequence
comprises the full-length coding sequence from within the sequence shown in
Figure 44 (SEQ ID
NO:118).

8. The nucleic acid of Claim 5 which comprises the full-length coding sequence
of
the DNA deposited under accession number ATCC 209670.

9. A vector comprising the nucleic acid of any one of claims Claim 1 to 8.

10. The vector of Claim 9 wherein said nucleic acid is operably linked to
control
sequences recognized by a host cell transformed with the vector.

11. A host cell comprising the vector of Claim 9 or Claim 10.

12 The host cell of Claim 11 wherein said cell is a CHO cell, an E. coli or a
yeast
cell.

13. A process for producing a polypeptide comprising culturing the host cell
of Claim
11 or Claim 12 under conditions suitable for expression of said polypeptide
and recovering said
polypeptide from the cell culture.

14. Isolated polypeptide comprising a sequence having at least 80% sequence
identity


to the amino acid sequence shown in Figure 45 (SEQ ID NO:119).
15. Isolated polypeptide comprising a sequence having at least 80% sequence
identity
to the amino acid sequence encoded by the nucleotide deposited under accession
number ATCC
209670.
16. Isolated polypeptide comprising a sequence having the amino acid sequence
shown in Figure 45 (SEQ ID NO:119).
17. Isolated polypeptide comprising a sequence having the amino acid sequence
encoded by the nucleotide deposited under accession number ATCC 209670.
18. A chimeric molecule comprising a polypeptide according to any one of
Claims 14
to 17, fused to a heterologous amino acid sequence.
19. The chimeric molecule of Claim 18 wherein said heterologous amino acid
sequence is an epitope tag sequence.
20. The chimeric molecule of Claim 18 wherein said heterologous amino acid
sequence is a Fc region of an immunoglobulin.
21. An antibody which specifically binds to a polypeptide according to any one
of
Claims 14 to 17.
22. The antibody of Claim 21 wherein said antibody is a humanised antibody.
23. The antibody of Claim 21 wherein said antibody is a monoclonal antibody.
24. The antibody of Claim 23 wherein said antibody is a chimeric antibody.
25 A composition comprising an antibody according to any one of Claims 21 to
24
inadmixture with a pharmaceutically acceptable carrier.

Description

CA 02421364 2003-03-25
DE1~IA~TDES OU BREVETS VOLUl~'IINEUX
LA PRESENTE PARTIE DE CETTE DEVLANDE OU CE BREVETS
COVIPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE
NOTE: Pour les tomes additionels. veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION i PATENT CONTAINS WORE
THAN ONE VOLUME.
THIS IS VOLUME OF
NOTE: For additional volumes please contact the Canadian Patent Office.

CA 02421364 2003-03-25
230 2 35 290
His Phe Leu Ala Leu Asp Al.a Ser Gln His Ser Ser Leu Ser Thr
245 a50 255
Arg Phe G.Ly Thr Val Ala Val Pro Asn 1.1e Leu Leu Phe C;ln Gly
260 a:65 270
Ala Lys P.ro Met. Ala Arg Phe Asn Hi.s fhr Asp Arg Thr Leu Glu
275 ~'80 285
Thr Leu Lys Ile Phe Ile Phe Asn G~~n Thr Gly Ile Glu Ala Lys
290 :?95 300
Lys Asn Vai. Val. Val Th:r Gl,n Ala Asp (~ln Il,e C~ly Fro L~eu Pro
305 310 315
Ser Thr Leu Ile L,ys Ser Val Asp Trp Leu Leu Val Phe Ser Leu
320 325 330
Phe Phe Leu Ile Ser Phe Il.e Met Tyr Ala Thr I:le Arg Thr Glu
335 340 345
Ser Iie Arg Trp Leu Ile Pro Gly Gln Glu Gln (~lu His 'Jal Glu
350 355 360
<210> 911
<211> 29
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 911
cacagagcca gaagtggcgg aatc 29
<210> 412
<211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial Seauence
<400> 912
ccacatgttc ctgctcttgt cctgg 25
<210> 413
<211> 45
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> I-45
<:223> Artificial Sequence
<900> 413
2 6 .:

CA 02421364 2003-03-25
cggtagtgac tgtactctag tcctgtttta caccccgtgg tgc:cg 45
-:210> 419
<:211> 1166
<:212> DNA
<:.213> Hcmo sapiens
<.-400> 419
cccggctccg ctccctctgc cccctcgggg t.cgc:gcgccc acgatgctcc 50
agggccctgg ctcgctgctg ctgctcttc~:~ tcgc:ctcgca ctgctgcctg 100
ggctcggcgc gcgggctctt cctctttggc cagcccgact tctcctacaa 150
gcgcagcaat t.gcaagccca tcccggtcaa cca<~cagctg tgccacggca 200
tcgaatacca gaacatgcgg ctg<vcc:aacc tgct:gggcca cgagaccatg 250
aaggaggtgc tggagcaggc cggc:gcttgg atcc.cgctgg tcatgaagca 300
gtgccacccg gacaccaaga agttcctgtg ctcgctct:tc gcccc:cgtct 350
gcctcgatga cctagacgag accatccaac catgcc:actc qctctgcgtg 400
caggtgaagg accgctgcgc ccc<gt:catg tccgccat.cg gcttcccctg 450
gcccgacatg cttgagtgcg accgtttc<:c ccaggacaac ctacct.ttgca 500
tccccctcgc tagcagcgac cac~:tcctgc cagccaccga ggaagctc~~a 550
aaggtatgtg aagcctgcaa aaataaaaat galgat.gaca <3cgacata;~t: 600
ggaaacgctt tgtaaaaatg attttg cac-t gaaaat.aaaa gtgaaggaga 650
taacctacat caaccgagat acc:~aaato.a t:cctgc~agac caagagcaag 700
accatttaca agctgaacgg tgtgtccg<aa agggacctga agaaatcggt 750
gctgtggct:c aaagacagct tgcagtgcu c ctgtg«ggag at:gaacgaca 800
tcaacgcgcc ctatctggtc atgggacaga aacagggtgg ggagctggtg 850
atcacctcgg tgaagcggtg gcagaagggg cagag,sgagt tcaagcgcat 900
ctcccgcagc atccgcaagc tgcagtgcT:a gtcccggcat cctgatggct 950
ccgacaggcc tgctccagag cacggctgac cat.ttctgct ccgggatctc 1000
agctcccgtt ccccaagcac actcctag:Jt gctccagtct cagcctgggc 1050
agcttccccc tgccttttgc acgtttgcat ccc:cagcatt tcctgagtta 1100
taaggccaca ggagtggata gctgttttca c:ct:aaaggaa aagcccaccc 1150
gaatcttgta gaaatattca aacaaataaa atc:atgaata ttttaa X196
<210> 915
<211> 295
<212> PRT
<213> Homo sapiens
<400> 915
Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser
26~:

CA 02421364 2003-03-25
1. 5 10 15
His Cys Cys Leu Gly Ser Al.a Arg Gly heu Phe Leu Phe Gly Gln
2G 25 30
Fro Asp Phie Ser Tyr Lys Arg Ser Asr~ C'ys Lys Fro Ile Pro Val
35 40 95
Asn Leu Gln Leu Cys His Gly Ile Glu Tyr Gir_ Asn Met ~?rg Leu
50 55 60
Fro Asn Leu Leu Gly His Glu Thr Met Lys G1u Val Leu C.lu Gln
65 70 75
Ala Gly Ala Trp Ile Pro Leu Val Met. Lys Gln C:ys His Faro Asp
80 85 90
Thr Lys Lys Phe L,eu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp
95 10C 105
Asp Leu Asp Glu Thr Ile Gin Pro Cys His Ser Leu Cys 'Jal Gln
11G 11~ 120
Va7. Lys Asp Arg Cys Ala Pro Va1 Met 5er Ala Phe Gly Phe Pro
125 130 135
Trp Pro Asp Met Leu Giu Cys AsL Arq Phe Pro Gln Asp Asn Asp
190 14 ~~ 150
Leu Cys Ile Pro Leu Ala Ser Ser Asp Hi:I~eu Leu Pro Ala Thr
155 16() 165
Glu Glu Ala Pro Lys Val Cys Glu Ala Cys hys Asn Lys Asn Asp
170 175 180
Asp Asp Asn Asp Ile Met Glu Th: heu Cys Lys Asn Asp Phe Ala
18~, 190 195
Leu Lys Ile Lys Val Lys Glu IlF, Thr Ty.r Ile Asn Arg Asp Thr
200 20'210
Lys Ile Ile Leu Glu Thr Lys Ser Lys Thr Ile Tyr Lys Leu Asn
215 220 225
Giy Val Ser Glu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys
230 235 290
Asp Ser Leu Gln Cys Thr C.'ys Glu Glu Met Asn Asp Ile Asn Ala
295 250 255
Pro Tyr Leu Val Met Gly Cain Lys Gln Gly Gly Glu Leu Val Ile
260 265 270
Thr Ser Val Lys Arg Trp Gln Lys G1y Gln Arg Glu Phe Lys Arg
275 280 285
Ile Ser Arg Ser I1e Arg Lys Leu Gln Cys
290 2cri
<210> 416
<211> 21
e212> DNA
<213> Artificial
263

CA 02421364 2003-03-25
~:220>
<221> Artificial Sequence
<222> 1-27.
<223> Artificial Sequence
<400> 416
cctggctcgc tgctgctgct c 21
<210> 9i7
<211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> :'~-25
<22:3> Artificial Sequence
<400> 41i
cctcacaggt gcactgcaag ctgtc 25
<210> 918
<211> 47
<2i2> DNA
<213> Arta.ficial
<220>
<221> Artificial Sequence
<222> 1-47
<223> Artificial Sequence
<400> 418
ctcttcctct ttggccagcc cgacttctcc tacaagcgca gaattgc 4'7
<210> 419
<211> 7830
<212> DNA
<213> Homo Sapiens
<900> 419
gtggaggccg ccgacgatgg cggggccgac ggaggccgag acggggtt.gg 50
ccgagccccg ggccctgtgc gcqcagcggg gcc:accgCac ctacgcgc;gc 100
cgctgggtgt tcctgctcgc gatcagcctg ctc~aactgct ccaacgcc;ac 150
gctgtggctc agctttgcac ctgtggctqa cgtcattgct gaggacttgg 200
tcctgtccat ggagcagatc aacac7gctgt cactagtcta cctcgtggta 250
tccaccccat ttggcgtggc ggc:catctgg atcctggact ccgtcgggct 300
ccgtgcggcg accatcctgg gtgcgtggct qaactttgcc gggagtgtgc 350
tacgcatggt gccctgcat.g gtt:gttgctga cccaaaaccc atttgccttc 900
ctcatgggtg gccagagcct ctgtgccctt gcccagagcc tggt:catct.t 450
ctctccagcc aagctggctg ccttgtggtt cccagagcac cagcgagcca 500
cggccaacat. gctcgccacc atc7tcgaacc ctctgggcgt ccttgtggcc 550
26~

CA 02421364 2003-03-25
aatgtgctgt: cccctgtgct ggtcaagaa~ ggtgaggaca ttccgttaat 600
gctcggtgtc: tataccatcc ctgctggcgi: c.gtca gcctg ctgtccacca 650
tctgcctgtq ggagagtgtg ccccccaccc~ cgccctctgc cggggctgcc 700
agctccacct cagagaagtt cctggatgg:4 ctcaagctgc agctcatgtg 750
gaacaaggcc tatgtcatcc tggctgtgtg cttgggggga atgatcggga 800
tctctgccag cttctcagcc ctcctggagc agat=cctctg tgcaagcggc 850
cactccagtg ggttttccgg cctctqtggc gctctcttoa tcacgtttgg 900
gatcctgggg gcactggctc tcggcc:ccta tgtc~gaccgg accaagcac:t 950
tcactgaggc c:accaagatt ggcctgtgcc tgttctctct ggcctgcgt:g 1000
ccctttgccc tggtgtccca gctgcaggga cagacccttg c:cctggctclc 1050
cacctgctcg ctgctcgggc tgtt=tggctt ctcggtgggc c:ccgtggcc:a 1100
tggagttggc ggtcgagtgt tcct~tcccc:g tgggggaggg ggctaccac~a 1150
ggcatgatct ttgtgctggg gcaggccgag ggaatactca 1=catgctggc 1200
aatgacggca ctgactgtgc gacgctcgc.a gccgtc:cttg tccacctgcc 1250
agcaggggga ggatccactt gactggacag tqtctctgct gctgatggcc 1300
ggcctgtgca ccttcttcag ctg:.atcctg gcggtc:ttct tccacacccc 1350
ataccggcgc ctgcaggccg agtctgggcta gcccccctcc ac:ccgtaacg 1400
ccgtgggcgg cgcagactca gggccgggtg tggaccgagg gggagcagga 1950
agggctgggg tcctggggcc cagcacgg~:g actccggagt gc:acggcgag 1500
gggggcctcg ctagaggacc ccagagggcc cgggagcc:cc cacccagcct 1550
gccaccgagc gactccccgt gcgcaaggc:c cagcagccac cgacgcgccc 1600
tcccgccccg gcagaca cgc aggcagggT~c c:aagcgtcca gg tttattga 1650
cccggctggg totcactcct ccttctcc~c cccgtgggtg atcacgtagc 1700
tgagcgcctt gtagtccagg ttccccgc-;:a catcgatgga ggcgaactgg 1750
aacatctggt ccacctgcgg gcgggggcga aagggctcct tgcggqctcc 1800
gggagcgaat tacaagcgcg cacct.gaaaa 1830
<210> 420
<211> 5E0
<212> PRT
<213> Homo Sapiens
<40C> 920
Met Ala Gly Pro Thr G1u Ala Glu Thr Gly Leu Ala Gl.u Pro Arg
1 5 10 15
Ala Leu Cys Ala Gln Arg Gly His Arg Thr Tyr Ala Arg Arg Trp
20 c:5 30
265

CA 02421364 2003-03-25
Val Phe Leu Leu Ala Iie Ser Leu Leu Asn Cys Ser Asn Ala Thr
3 5 40 45
Leu Trp Leu Ser Phe Ala Pro Val Ala F~sp Val Ile Ala C-l.u Asp
50 55 60
Leu Val Leu Ser Met Glu Gln Ile Asn 1.'rp Leu Ser Leu Va1 Tyr
65 70 75
Leu Val Val Ser Thr Pro Phe Gly Val Ala Ala Ile Trp Ile Leu
80 85 90
Asp Ser Val Gly Leu Arg Ala Ala Thr Ile Leu Gly Ala Trp Leu
9'.i L00 105
Asn Phe Ala Gly Ser Val Leeu Arq Met Val Pro C;ys Met: ~~'al Val
I10 115 120
Gly Thr Gln Asn Pro Phe A:a Pha Leu Met Gly Gly Gln Ser Leu
125 130 135
Cys Ala Leu Ala Gln Ser Lf~u Val Ile Phe Ser Pro Ala Lys Leu
190 14,~ 150
Ala Aia Leu Trp Phe Fro Glu His Gln Arc( Ala Thr Ala Asn Met
155 160 165
Leu Ala Thr Met Ser Asn Pro Let: Gly Va7_ Leu Val Ala Asn Val
170 175 180
Leu Ser Pro Val Leu Val Lys Ly:; G1y Glu Asp Ile Pro Leu Met
185 19(1 195
Leu Gly Val Tyr Thr I.Le Pro Ala.: Gly Val Val Cys Leu Leu Ser
200 20'~~ 210
Thr Ile C:ys Leu Trp Glu Ser Va. Pro Pro Thr Pro Pro Ser Ala
215 22.7 225
Gly Ala Ala Ser Ser Thr Ser Glu Lys Ph~~ Leu Asp Gly Leu Lys
230 235 290
Leu Gln Leu Met Trp Asn Lys A1~3 T'yr Val lle Le a Ala Val Cys
245 25t'? 255
Leu Gly Gly Met Ile Gly Ile Se.r Aia Ser Phe Ser Ala Leu Leu
260 265 270
Glu Gln Ile Leu Cys Ala Ser Gly His Ser Ser Gly Phe Ser Gly
275; 280 285
Leu Cys Gly Ala Leu Phe Lle Thr Plie Gly Ile Leu Gly Ala Leu
290 295 300
Ala Leu Gly Pro Tyr Val Asp Arg Thr Lys His Phe Thr Glu Ala
305 310 315
Thr Lys Ile Gly Leu Cys Leu Phe Ser Leu Ala Cys Val Pro Phe
320 325 330
Ala Leu Val Ser Gln Leu Gln Gly Gln Thr Leu Ala Leu Ala Ala
335 340 345
26(

CA 02421364 2003-03-25
Thr Cys Ser I_,eu Leu Gly Leu Phe Gly Fhe Ser Val Gly Pro Val
350 355 360
Ala Met Glu Leu Ala Val Glu Cys Ser Fhe Pro Val Gly Glu Gly
365 X70 375
Ala Ala Thr Gly Met I12 Phe Val Leu C~ly G:n Ala Glu Gly Ile
380 ,85 390
Leu Ile Met Leu Ala Met Thr Ala Leo Thr Val Arg Arg Ser Glu
395 400 405
Fro Ser Leu Ser Thr Cys Gln Gln G1y Glu Asp Pro Leu Asp Trp
410 415 420
Thr Val Ser Leu Leu Leu Met Ala Gly Leu Cys Thr Phe Phe Ser
425 430 935
Cys Ile Leu Ala Val Phe Ptue His Thr Prc Tyr Arg Arg Leu Gln
940 495 450
Ala Glu Ser Gly Glu Pro Pro Ser Thr Arg Asn I'~la Vai C;ly Gly
455 96C 465
Ala Asp Ser Gly Pro Gly Val Asp: Arg Gly Gly Ala C;ly Arg Ala
970 47~=. 480
Gly Val Leu Gly Pro Ser Thr Ala Thr Pro Glu Cys Thr Ala Arg
485 990 495
Gly Ala Ser Leu Glu Asp Pro Arc: Gly Pro Gly Ser Faro His Pro
5O0 SO5 51O
Ala Cys His Arg Ala Thr Pro Arg Aia Gln Gly Pro Ala Ala Thr
515 520 525
Asp Ala Pro Ser Arg Pro G.Ly Ar<I Leu Ala Gly Arg Val Gln Ala
530 535 540
Ser Arg Phe Ile Asp Pro A.la Gly Ser Hi:: Ser Ser Phe Ser Ser
545 550 555
Pro Trp Val Ile 'Thr
560
<210> 421
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 421
agcttctcag ccctcctgga gcag 24
<210> 422
<211> 25
<212> DNA
<213> Artificial
26i

CA 02421364 2003-03-25
<220>
~:221> Artificial Sequence
<222> 1-25
<223> Artificial Sequence
<900> 422
cgggtcaata aacctggacg cttqg 25
<210> 923
<:211> 43
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-43
<223> Artificial Sequence
<900> 423
tatgtggacc ggaccaagca ctt.cactgag gccacc:aaga Ltg 43
<210> 424
<211> 9313
<212> DNA
<213> Homo Sapiens
<900> 424
gtcccacatc ctgctcaact gggtcaggt.c cctct~agac cagctcttgt 50
ccatcatttg ctgaagtgga ccaactagtt ccccagtagg gggtctcccc 100
tggcaattct tgatcggcgt ttggacatc,t cagat~~gctt ccaatgaaga 150
tggccttgcc ttggggtcct gcttgtttca taatcatcta actatgggac 200
aaggttgtgc cggcagctct gggggaagc;a gcacggggct gatcaagcca 250
tccaggaaac actggaggac ttgtccag c ttgaaagaac tctagtggtt 300
tctgaatcta gcccacttgg cggtaagcat gatgcaact.t ctgcaacttc 350
tgctggggct tttggggcca ggt:ggctac.~t tat:ttctt_t..t aggggattgt 400
caggaggtga ccactctcac ggtgaaatac caagtgtcag aggaagtgcc 450
atctggtaca gtgatcggga agc:tgtccca ggaactgggc cgggaggaga 500
ggcggaggca agctggggcc gccttccagg tgttgcagct gcctcaggcg 550
ctccccattc aggtggactc tgaggaaggc ttc~ctcagca caggcaggcg 600
gctggatcga gagcagctgt gcc:gacagtg ggatccct.gc ctggttt,:ct 650
ttgatgtgct tgccacaggg gat.ttggctc tgatccatgt ggagatccaa 700
gtgctggaca tcaatgacca ccagccacgg tttcccaaag gcgagcagga 750
gctggaaatc tctgagagcg cctc~ctc;cg aaccc:ggatc c:ccctggac;a 800
gagctcttga cccagacaca ggccctaaca ccctgcacac ctacactctg 850
tctcccagtg agcactttgc cttggatetc attgtgggcc ctgatgagac 900
26c

CA 02421364 2003-03-25
caaacatgca gaactcatag tggtgaagga gctggacagg gaaatccatt 950
cattttttga tctggtgtta actgcctatg ac:aatgggaa <:ccccccaag 1000
tcaggtacca gcttggtc:aa ggtc:aacgtc ttggactcca atgacaatag 1050
ccctgcgttt gctgagagtt cactggcact ggaa atccaa cfaagatgctg 1100
cacctggtac gcttctcata aaacagaccg ccacagaccc t:gaccaagc~c 1150
cccaatgggg aggtggagtt cttrc~caCt aagcac:atgc <a ccagaggt 1200
gctggacacc ttcagtattg atgc:c~aag~ac aggccaggtc attctgcgtc 1250
gacctctaga ctatgaaaag aacc:ctgcct acgaggtc:ga t=gtt<:aggca 1300
agggacctgg gtcccaatcc tat.cccagec cattg<:aaag ttctcatcaa 1350
ggttctggat gtcaatgaca acatccca<ag cat.cca cgtc acatgggcct 1900
cccagccatc actggtgtca gaagctcttc ccaaggacag ttttattgct 1450
cttgtcatgg cagatgactt ggattcagya cacaat.ggt.t tggtccactg 1500
ctggctgagc caagagctgg gccacttcGzg gctgaaaaga actaatggca 1550
acacatacat gttgctaacc aatgccaca c tggacagaga gcagtggccc 1600
aaatataccc tcactctgtt agcccaag:~c caagga ctcc agcccttatc 1650
agccaagaaa cagctcagca ttcagatc;ig t gacatcaac gacaatgcac 1700
ctgtgtttga gaaaagcagg tatgaagt~:t c;:acg.:ggga aaacaactta 1750
ccctctcttc acctcattac catcaagg:~t catgatgcag acttgggcat 1800
taatggaaaa gtctcatacc gcatccagga ctccccagtt gctcacttag 1850
tagctattga ctccaacaca ggagaggtca ctgctcagag gtcactgaac 1900
tatgaagaga tggccggctt tgagt.tccag gt<~atcg:ag aggacagcgg 1950
gcaacccatg cttgcatcca gtgtctctgt gtgggtcagc ctcttggatg 2000
ccaatgataa tgccccagag gtggt:ccagc ctgtgctcag cgatggaaaa 2050
gccagcctct ccgtgcttgt gaatgcctcc acaggccacc tgctggtgcc 2100
catcgagact cccaatggct. tgggc:ccagc gggcactgac acacctccac 2150
tggccactca cagctcccgg ccattccttt tgacaa<:cat. tgtggcaaga 2200
gatgcagact cgggggcaaa tggagagccc <:tctacagca tccgcaatgg 2250
aaatgaagcc cacctcttca tcctcaaccc tcatacgggg cagcagttcg 2300
tcaatgtcac caatgccag<: agcctcat tg ggagt.gagtg ggagctggag 2350
atagtagtag aggaccaggg aagc~ccrvcc ttacagaccc gagccctgtt 2400
gagggtcatg tttgtcacca gtgtgga<:ca c:ctg<igggac tcagcccgca 2950
2 6'-?

CA 02421364 2003-03-25
agcctggggc cttgagcatg tcg<itgctga c:c~gr_gatctg cctggctgta 2500
ctgttgggca tcttcgggtt gatc;ctggct to gt:tcatgt ccatctgccg 2550
gacagaaaag aaggacaaca gggcctacaa ctgtcgggag accgagtcca 2600
cctaccgcca acagcccaag aggc:cc:caga aacacattca gaaggcagac 2650
atccacctcg tgcctgtgct caggggtcag gcaggtgagc catgt:gaagt 2700
cgggcagtcc cacaaagatg tggacaagga ggcgatgatg gaagcaggct 2750
gggacccctg cctgcaggcc ccct:tccacvc tcaccc:cgac cctgtacagg 2800
acqctgcgta atcaaggcaa ccagggagca ccggcqgaga gccgagaggt 2850
gctgcaagac acggtcaacc tcc~:tttc«a ccatcccagg cagaggaatg 2900
cctcccggga gaacctgaac cttc:ccgac:c cccagc;ctgc cacaggccag 2950
ccacgttcca ggcctctgaa ggttgcagcc agcccc:acag ggaggctggc: 3000
tggagaccag ggcagtgagg aag~cccac:a gaggc<:acca gcctc:ctctg 3050
caaccctgag acggcagcga catctcaat.g gcaaa<7tc~tc cc:ctgagaaa 3100
gaatcagggc cccgtcagat cctgcggactc ctggtc:cggc tgtctgtggc 3150
tgccttcg<:c gagcggaacc ccgtggagga gctcactgtg gattctcctc: 3200
ctgttcagca aatctcccag ctgctgtc~::t tgctgcatca gggccaattc 3250
cagcccaaac caaaccaccg aggaaataag tacttggcca agccaggagg 3300
cagcaggagt gcaatcccag aca<:agat«g ccc:aagtgca ag ggctggag 3350
gccagacaga cccagaacag gaggaagggc ctttggatcc tgaagaggac 3400
ctctctgtga agcaactgcr_ agaaaaagag ctgtcaagtc tgctggaccc 3450
cagcacaggt ctggccctgg accggctgag cgc:ccctgac ccggcctgga 3500
tggcgagact ctctttgccc ctcac:cacca act:accatga caatgtgatc 3550
tccccggatg ctgcagccac ggaggagcc:g aggaccttc:c agacgttc:gg 3600
caaggcagag gcaccagagc t.gagcccaac aggcac:gagg ctggccac,aca 3650
cctttgtctc ggagatgagc tcact:gctgg agatgctgct ggaacagcgc 3700
tccagcatgc ccgtggaggc cgcctccaag gcg ctgcggc ggctctcggt 3750
ctgcgggagg accctcagtt tagacttggc caccagtgca gcctcaggca 3800
tgaaagtgca aggggaccca ggtggaaaga cgggga ctga gggc:aagagc 3850
agaggcagca gcagcagcag cagg,-_gcctg tgaac:atacc rcagacgc ct 3900
ctggatccaa gaaccagggg cctgaggatc tgtggacaag agctggtttc 3950
taaaatcttg taactcacta gctagcgrcg gcctgagaac tttagggtga 9000
ctgatgctac ccccacagag gagg~aaUag cccc<sggact aacagctgac 4050
G 71)

CA 02421364 2003-03-25
tgaccaaagc agccccttgt aagcagctct gagtcttttg gaggacaggg 4100
acggtttgtg gctgagataa gtgtttcctg gcaaaacata tgtggagcac 4150
aaagggtcag tcctctggca gaacagatgc cacggagtat c:acaggcagg 9200
aaagggtggc ctt.cttgggt agcaggagt;~ agggggctgt accctggggg 9250
tgccaggaaa tgctctctga cctatcaata aaggaaaagc agtaaaaaaa 9300
aaaaaaaaaa aaa 9313
<210> 425
<211> 1184
<212> PRT
<213> Hcmc sapiens
<400> 925
Met Met Gln Leu Leu Gln Lau Lei: Leu Gly Leu Leu Gly Pro Gly
1 5 10 15
Gly Tyr Leu Phe Leu heu Gly Asp Cys Gln C;lu '~,lal. Thr 'rhr Leu
20 25 30
Thr Val Lys Tyr Gln Val Ser Glu Glu Vaa Pro Ser c~ly Thr Val
35 9(~ 45
Ile Gly Lys Leu Ser Gln Gl.u Lets Gly Arcx C;lu Glu Arg Arg Arg
(~ 5 !':~ 6 0
Gln Ala Gly Ala Al.a Phe Gln Vas I_,eu Gln Leu Prc Gln Ala Leu
65 70 75
Pro I 1e C;ln Val Asp Ser C.lu Gl az Gly Leiz Leu Ser Thr Gly Arg
80 85 90
Arg Leu Asp Arg Glu Gln Leu Cys Arg Gln Trp Asp Fro Cys Leu
95 100 105
Val Ser Phe Asp Val Leu Ala Thr G1y Asp Leu Ala Leu Ile His
710 115 120
Val Glu Ile Gln Val Leu Fap I12 Asn Asp His Gln Pro Arg Phe
125 130 135
Pro Lys Gly Glu Gln Glu Leu Glu Ile Ser Glu Ser Ala Ser Leu
140 145 150
Arg Thr Arg Il.e Pro Leu I~sp Arg Ala Leu Asp Fro Asp Thr Gl.y
155 1E0 165
Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro Ser G1u His Phe
170 1i5 180
Ala Leu Asp Val Ile Val. (~ly Pro Asp Glu Thr Lys His Ala Glu
18.5 190 195
Leu Ile Val Val Lys Glu Leu A:p Arg Glu Ile His Ser Phe Phe
200 205 210
Asp Leu Va1 Leu Thr Ala 'iyr Asp Asn Gly Asn Pro Pro Lys Ser
215 2'<?0 225
2 7 :!

CA 02421364 2003-03-25
Gly Thr Ser Leu Val_ Lys Val Asn Val. Leu Asp Ser Asn Asp Asn
230 '~35 290
Ser Pro Ala Fhe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu
295 25~ 255
Asp Ala Ala Pro Gly Thr Leu Leu Iie Lye 1:eu Thr Ala Thr Asp
260 265 270
Pro Asp Gln Gly Prc Asn G:Ly Glt: Val Glu Phe Phe Leu :per Lys
2_75 280 285
His Met Pro Pro Glu Val Lceu AsP Thr Phe Ser Ile Asp Ala Lys
29C 295 300
Thr Gly Gln Val Ile heu Arg Arc; Pr~J Leu Asp Tyr Glu Lys Asn
305 31c) 315
Pro Ala Tyr Glu Val Asp Va:31 Gln Ala Arca Asp Leu Gly Pro Asn
320 32', 330
Pro Ile Pro Ala His Cys Lys Vas Leu Ilc~ Lys Val Leu Asp Val
335 390 395
Asn Asp Asn ile Pro Ser Ile Hi> Val Th:r Trp .Ala Ser Gln Pro
350 355 360
Ser Leu Val Ser Glu Ala Leu Pr..; Lys Asp Ser Phe Ile Ala Leu
365 37J 375
Val Met Ala Asp Asp Leu Asp Sec Gly His Asn Gly Leu Val His
380 385 390
Cys Trp Leu Ser Gln Glu Leu G1~,~ His Phe Arg Leu Lys Arg Thr
395 400 905
Asn Gly Asn Thr Tyr Me~ Leu Le~.~ Thr Asn Ala Thr Leu Asp Arg
410 41r> 420
Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala Gln Asp Gln
425 430 435
Gly Leu Gln Pro Leu Ser A1<f Lys Lys Gln Leu Ser Ile Gln Ile
940 945 950
Ser Asp Ile Asn Asp Asn Ala Pro Vai Phe Glu Lys Ser Arg Tyr
955 4E0 965
Glu Val Ser Thr Arg Glu Asn A:n Leu Pro Ser Leu His Leu Ile
470 9i5 480
Thr Ile Lys Ala His Asp Ala A::p Leu Gly Ile Asn Gly Lys Val
985 990 995
Ser Tyr Arg Ile Gln Asp .'3er Pro Val Al.a His Leu Val Ala Ile
500 505 510
Asp Ser Asn Thr Gly Glu Val TY:r Ala Gln Arg Ser Leu Asn Tyr
515 5a0 525
Glu Glu Met Ala Gly Phe Glu Ptie Gln V<il Ile Ala G.lu Asp Ser
530 535 590
27

CA 02421364 2003-03-25
Gly Gln Pro Met Leu Ala Ser Ser Val Ser Val. Trp Val ~er Leu
545 550 555
Lea Asp Ala Asn Asp Asn Ala Prc Gl.u Val Va.l Gln Pro Val Leu
560 565 570
Ser Asp Gly Lys Ala Ser Leu Ser Val. Leu Val Asn Ala Ser Thr
57~; 580 585
Gly His Leu Leu Val Pro Ile Glu T'hr Prc Asn C:ly Leu Gly Pro
590 595 600
Ala Gl.y Thr Asp Thr Pro Pro Let: A.Ia Thr His >er Ser Arg Pro
605 610 615
Phe Leu Leu Thr Thr Ile Val Ala Arg Asp Ala Asp Ser Gly Ala
E;20 62'_; 630
Asn Gly Glu Pro Leu Tyr Ser IlE Arg Asn C~ly Asn Glu Ala His
635 690 695
Leu Phe Ile Leu Asn Pro H:is Thr Gly Glrn Leu 1?he Val Asn Val
650 65': 660
Thr Asn Ala Ser Ser heu Ile G11~ Ser Glu Trp Giu Leu Glu Ile
665 670 675
Val Val Glu Asp Gln Gly Ser Prc~ Pro Leu Gln 'Thr Arg Ala Leu
Esc 6a5 690
Leu Arg Val Met Phe Val Thr Se_ Val Asp His Le:u Arg Asp Ser
695 700 705
Ala Arg Lys Pro Gly Ala Leu SeY Met 5er Met Leu Thr Va7. Ile
710 71~ 720
Cys Leu Ala Val Leu Leu Gly I1~.. Phe Gly Leu Ile Leu Ala Leu
72 ~ 730 735
Phe Met 5er Il,e Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr
740 795 750
Asn Cys Arg Glu Ala Glu Ser Thr Tyr Arg Gln G.ln Pro Lys Arg
755 '760 765
Pro Gln Lys His Ile Gln Lys Al.a Asp Ile His Leu Val Pro Val
770 775 780
Leu Arg Gly Gln Ala Gly Glu Pro Cys Glu Val. Gly Gln Ser His
785 790 795
Lys Asp Val Asp Lys Giu Ala Met Met Glu Al,a Gly Trp Asp Pro
800 8C5 810
Cys Leu Gln Ala Pro Phe His LEU 'I'hr Pro Thr Leu Tyr Arg Thr
815 820 825
Leu Arg Asn Gln Gly Asn Gln Gly Ala Pro Ala Glu Ser Arg Glu
830 8~~5 840
Val Leu Gln Asp Thr Val flsn Leu Leu Phe Asn His Pro Arg Gln
895 8_'>0 855
273

CA 02421364 2003-03-25
Arg Asn Ala Ser Arg G.lu A:.n Leu Asn Leu Pro Glu Pro Gln Pro
860 865 870
Ala Thr Gly Gln Pro Arg Ser Arg Fro Leu hys Val Ala Gly Ser
875 880 885
Pro Thr Gly Arg Leu Ala G7y Asp G1n Gly Ser Glu Glu P.la Pro
890 895 900
Gln Arg Pro Fro Ala Ser Sm Ala Thr Leu Arg Arg Gln Arg His
905 91C 915
Leu Asn Gly Lys Val Ser Pro Glu Lys GlL Ser Gly Pro I:rg Gln
920 925 930
Ile Leu Arg Ser heu Val Arg Leu Ser Val A1a Ala Phe Ala Glu
935 940 945
Arg Asn Pro Val Glu Glu Leu Thr Val AsF; Ser Pro Pro 'Jal Gln
950 95_'> 960
Gln Ile Ser Gln Leu Leu Ser Lei: Leu His Gln Gly G1n Phe G1n
965 970 975
Prc Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala hys Pro Gly
980 985 990
Giy Ser Arg Ser Ala Ile Fro AsFa Thr Asp Gly Pro Ser Ala Arg
995 7000 1005
Ala Gly G1y Gln Thr Asp Pro G1u Gln G1u Gl.u Gly Pro Leu Asp
1010 101.' 1020
Pro Glu Glu Asp Leu Ser Val Lys Gln Leu Leu Glu Glu Glu Leu
1025 103 1035
Ser Ser heu Leu Asp Pro Ser Th~. Gly Lea Ala Leu Asp Arg Leu
1090 1045 1050
Ser Ala Pro Asp Pro Ala Trp Me:_ Ala Arg Leu Ser Leu Pro Leu
1055 7060 1065
Thr Thr Asn Tyr Arg Asp Asr_ Val Ile Ser Pro Asp Ala Ala Ala
1070 1075 1080
Thr Glu Glu Pro Arg Thr F'he GlTLur Phe Gly Lys Ala Glu Ala
1085 1090 1095
Pro Glu Leu Ser Pro Thr Gly 'I'hr Arg Leu A1a Ser Thr Phe Val
1100 1105 1110
Ser Glu Met Ser Ser Leu l.,et: Glu Met. Leu Leu Glu Gln Arg Ser
1115 L120 1125
Ser Met Pro Val Glu Ala A1<3 SE:r Glu Ala Leu Arg Arg Leu Ser
1130 1135 1140
Val Cys Gly Arg Thr Leu Ser Leu Asp Leu Ala Thr Ser Ala Ala
1195 11_'~0 1155
Ser Gly Met Lys Val Gln Gly Asp Pro Gly Gly Lys Thr Gly Thr
'_160 1165 1170
274

CA 02421364 2003-03-25
Glu Gly Lys Ser Arg G.ly Ser Sex Ser ;>er Ser Arg Cys Leu
1175 1.'L80
<210> 426
<211> 29
<212> DNA
213> Artificial
<220>
'221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<400> 426
gtaagcacat gcctccagag gtga 29
<210> 927
<211> 29
<2i2> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 427
gtgacgtgga tgcttgggat gttg 29
<2i0> 928
<21.1> 50
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-50
<223> Artificial Sequence
<900> 928
tggacacctt cagtattgat gccaagacag gcc:aggtcat tctgcgtcga 50
<210> 429
<211> 2037
<212> DNA
<213> Homo sapiens
<400> 429
cggacgcgtg ggcggacgcg tggg<lgagag ccgcagtccc ggctgcagca 50
cctgggagaa ggcagaccgt gtgagggggc ctgtgg<:cc:c agcgtgctgt 100
ggcctcgggg agtgggaagt ggaggcaqga gccttcctta cacttcgcca 150
tgagtttcct catcgactcc: agc:a~catga tt:acc:tc:cca gatacta~tt 200
tttggatttg ggtggctttt ct~~catgcgc caatt.gttta aagactatga 250
gatacgtcag tatgttgtac aggtgatott ctccgtgacg tttgcatttt 300
cttgcaccat gtttgagctc atcatctttg aaatcatagg agt<~ttgaat 350
2 7 '~

CA 02421364 2003-03-25
agcagctccc gttattttca ctggaaaatg aacctgtgtq taattctgct 400
gatcctggtt ttcatggtgc ctt2ttacat: t:qgctatttt ~;ttgtgagca 450
atatccgact actgcataaa caac:gactac ttttttcctc~ tctcttatgg 500
ctgaccttta tgtatttctt ctgga<~acta gga~~atcc;ct t tcc:c:attc:t 550
cagcccaaaa catgggatct tatc:cataga acagct.catc agccgggttg 600
gtgtgattgg agtgactctc atg~~c~_cttc tttctc~ga:~ti- ?:ggtgctgtc 650
aactgcccat acacttacat gtcvtacttc ctcag<ta<itg t gact.gacac: 700
ggatattcta gccctggaac ggcga~,tgct gcaaac:catg c3atat:gatca 750
taagcaaaaa gaaaaggatg gcaatggca,c qgagaacaat qttccagaag 800
ggggaagtgc ataacaaacc atcaggtt?.c tggggaatga ~aaaaagtgt 850
taccacttc;a gcatcaggaa gtgaaaat<:.t tactct:tatt :~aacaggaag 900
tggatgcttt ggaagaatta agcaggcagc tLtttctgga aacagctgat 950
ctatatgcta ccaaggagag aatagaat<~c tc caaaacct tcaaggggaa 1000
atattttaat tttcttggtt_ actttttc?:c tatttactgt gtttggaaaa 1050
ttttcatggc taccatcaat attgtttttg atcgagttgg gaaaacggat 1100
cctgtcacaa gaggcattga gatcactgt:g aattatct.gg g<iatccaatt 1150
tgatgtgaag ttttggtccc~ aacacatt'c c:ttcattctt gttggaataa 1200
tcatcgtcac atccatcaga ggattgctga tcactcttac caagttcttt 1250
tatgccatct ctagcagtaa gtcctccaat gt<:attgtcc tgctattagc 1300
acagataatg ggcatgtact ttqtctcc;.c tqt:gctqctg atccgaatga 1350
gtatgcecttt agaataccgc accataatca ct:~aagtcca tggagaactg 1900
cagttcaact tctatcaccg ttqgt:ttgat gtgatcttcc tggtcagcgc 1950
tctctctagc atactcttcc tctatttggc tc~acaaacag gcaccagaga 1500
agcaaatggc accttgaact taagcctact acagactgtt agaggccagt 1550
ggtttcaaaa tttagatata agag<3gggga aaaatggaac cagggcc?.ga 1600
cattttataa acaaacaaaa tgctatggta gcatttttca ccttcatagc 1650
atactccttc: cccgtcaggt gat:ac tatga ccatgagtag catcagccag 1700
aacatgagag ggagaactaa ctcaagacaa tactc:agcag agagcatccc 1750
gtgtggatat gaggctggtg tagaggcgga gaggagccaa gaaactaaag 1800
gtgaaaaata cactggaact= ctggggcaag acatgtctat ggtagctgag 185C
ccaaacacgt aggatttccg ttttaagcrt.t cacatggaaa aggttatagc 1900
tttgccttga gattgactca tt:aaaatc:ag agaci:gtaac aaaaaaaaaa 1950
27v

CA 02421364 2003-03-25
aaaaaaaaaa agggcggccg cgacactaga gtcgacctgc agaagcttgg 2000
ccgccatggc ccaacttgtt tatt.gcagct tataatg 2037
<210> 430
<211> 455
<2,12> PRT
<213> Homo sapiens
<400> 930
Met Ser Phe Leu Ile Asp Ser Ser Il.e Met Ile Thr Ser ~:~lr: Ile
1 5 10 15
Leu Phe Phe Gly Fhe Gly Trp Lea: Phe Fhe Met Arg Gln Leu Phe
2 0 2 .'> 3 0
Lys Asp Tyr Glu Ile Arg Gln Tyn Val Val Gln 'Jal Ile Phe Ser
35 40 95
Val Thr E'he Ala Phe Ser Cys Th:- Met Phe Gla Leu Ile Ile Fhe
50 55 60
Glu Ile Leu Gly Val Leu Asn Se:- Ser 5er Arg Tyr Phe His Trp
65 70 75
Lys Met Asn Leu Cys Val Ile Lea Leu Ile Leu Val Phe Met Val
80 85 90
Pro Fhe Tyr Ile Gly Tyr Phe Ile Val Ser Asn Ile Arg Leu Leu
95 100 105
His Lys Gln Arg Leu Leu Fhe Ser Cys Leu Leu Trp Leu Thr Phe
110 11 5 120
Met Tyr Phe Phe Trp Lys I_eu Gly Asp Pro Phe Fro Ile Leu Ser
125 130 135
Pro Lys His Gly Ile Leu Ger Il= Glu Gln Leu Ile Ser Arg Val
140 195 150
Gly Val Ile Gly Val Thr Leu Met Ala Leu Leu Ser Gly Phe Gly
155 16C 165
Ala Val Asn Cys Pro T'yr Thr Tyr Met Ser Tyr Phe Leu Arg Asn
170 175 180
Val Thr Asp Thr Asp Ile Leu Ala Leu Glu Arg Arg Leu Leu Gln
185 190 195
Thr Met Asp Met Ile Tle :~er Lys Lys Lys Arg Met Ala Met Ala
200 2Ci5 2.10
Arg Arg Thr Met Phe Gln ~~ys Gly Glu Val. His Asn Lys Pro Ser
215 2~.'0 225
Gly Phe Trp Gly Met Ile Lys Seer Val Thr Thr Ser Ala Ser Gly
230 23S 240
Ser Glu Asn Leu Thr Leu Ile G'n Gln Glu Val Asp Ala Leu Glu
245 250 255
Glu Leu Ser Arg Gl.n Leu Phe LE~u Giu Thr Ala Asp Leu Tyr Ala
27'i

CA 02421364 2003-03-25
260 a?65 270
Thr Lys Glu Arg Ile Glu Tyr Ser Lys "Chr Phe L,ys Gly Lys Tyr
275 280 285
Phe Asn Phe Leu Gly Tyr Phe Phe Ser :Cle Tyr C.'ys Val Trp Lys
290 .?95 300
Ile Phe Met Ala Thr Ile Asn Il.e Val Phe Asp Arg Val c~ly Lys
305 310 315
Thr Asp Prc Val Thr Arg G7y Ile Gltr Ile Thr Val Asn syr Leu
320 32C~ 330
Gly Ile Gln Fhe Asp Val Lys PhE Trp Ser Gln C~is Ile Ser Phe
33_': 39C? 345
Ile Leu Val Gly ile Ile Ile Va? Thr Ser Ile Arg Gly Leu Leu
350 355 360
Ile Thr Leu Thr Lys Phe Ph a Tyr A).a Ile Ser Ser Ser ~ys Ser
365 37C? 375
Ser Asn Val Ile Val heu Leu Leu Ala Gln Ile Met Gly Met. Tyr
380 385 390
Phe Val Ser Ser Val Leu Leu Ilt~ Arg Met= Ser Met Pro Leu Glu
395 900 405
Tyr Arg Thr ile Ile Thr Glu Va.l. heu Gly Glu Leu Gln Phe Asn
910 41','~ 920
Phe Tyr His Arg Trp Phe Asp Va? Ile Phe Leu Val Ser Ala Leu
425 93J 935
Ser Ser Ile Leu Phe Leu Tyr Letr A.la His hys Gln Ala Pro Glu
940 495 950
Lys Gln Met Ala Frc
455
<210> 431
<211> 907
<212> DNA
<21.3> Homo Sapiens
<220>
<221> unsure
<222> 78, 81, 113, 157, 224, 297
<223> unknown base
<90C> 431
catgggaagt ggagccggag ccitccttac actcgccatg agtttcct;.ca 50
tcgactccag catcatgatt acc:tcccnga nactattttt tggatttc~gg 100
tggcttttct tcngcgccaa tgtttaaaga ct:atcagata cgtcagtatg 150
ttgtacnggt gatcttctcc gtgacgtttg cc<~ttt:c:ttg caccatgl_tt 200
gagctcatca tctttgaaat cttnggacta ttgaatagca gctcccgtta 250
ttttcactgg aaaatgaacc tgtg-gtaat tctgctgatc ctggttntca 300
278

CA 02421364 2003-03-25
tggtgccttt ttacattggc tattttattg tgagcaatat ccgactactg 350
cataaacaac gactgctttt tt.cc tc~tctc ttatggctga cctttatgt a 900
tttccag 407
<210> 932
<2.11> 457
<212> DNA
<213> Homo sapiens
<220>
<221> unsure
<222> 31, 66, 81-82, 89, 122, 1~4, 187, 232, 241, 900, 424, 427, 434
<Z23> unknow:~ base
<400> 432
gtgttgccct tggggagggg aaggggagc-c nggcc<attc ctaaaatttg 50
gccaagggtt tctttnttga att:cgggtt nngnat=acct tcccagaaaa 100
tattttttgg atttggggta gntttttttc atgcgccaat ~gtttaaaga 150
ctatgagata cgtcagtatg ttgtacagcrt gatntl_ntcc gt:ga<:gtttg 200
cattttcttg caccatgttt gagctcat;va tntttgaaat ~t:taggagta 250
ttgaatagca gctcccgtta ttttcactqg aaaatgaacc tgtgtgtaat 300
tctgctgatc ctqgttttca tggtgccttt ttacattggc t.attttattg 350
tgagcaatat ccgactactg cataaaca=is gactg~~tttt ttcctgtctn 900
ttatggctga cctttatgta tttnttnt.lg aaantaggag atccctttcc 450
cattctc 457
<210> 433
<211> 20
<212> DNA
<213> Artificial
<22C>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 93.:
aagtggagcc ggagccttcc 20
<210> 434
<211> 22
<212> DNA
<213> Artificial
<:220>
<221> Artificial Sequence
<222> 1-22
<223> Artificial Sequence
<400> 439
tcgttgttta tgcagtagtc gg 22
2 7 ~a

CA 02421364 2003-03-25
<210> 435
211> 4"_
s212> DNA
<213> Artificial
<220>
~:221> Artificial Sequence
~222> 1-91
<223> Artificial Sequence
<400> 435
attgtttaaa gactatgaga tacgtc agt.a tgttgtacag c3 41
<210> 436
<211> 3951
<212> DNA
<213> Homo sapiens
<900> 436
ctcgcgcagg gatcgtccca tggccgggc:rc tcggac~ccgc gacccttggg 50
gggcctccgg gatttgctac: ctttttggct ccctgctcgt cgaactgctc 100
ttctcacggg ctgtcgcctt caatctggac gtgatgggtg ccttgcgcaa 150
ggagggcgag ccaggcag cc tcttcggcr_t ctctgtggcc ctgcaccggc 200
agttgcagcc ccgaccccag agctggctgc tggtgg gtgc tccccaggcc 250
ctggctcttc ctgggcagca ggcgaatcgc act.ggaggcc tcttcgcttg 300
cccgttgagc ctggaggaga ctgactgcta cagagtggac atcgaccagg 350
gagctgatat gcaaaaggaa agcaaggaga ac<:agtggtt gggagtcagt 900
gttcggagcc aggggcctgg gg<~caagatt gtt:acc:tgtg cacaccgata 950
tgaggcaagg cagcgagtgg aceagatcct ggagacgcgg gatatgattg 500
gtcgctgctt tgtgctcagc caggacctgg ccatccagga tgagtt.gqat 550
ggtggggaat ggaagttctg tgagggacgc ccc:caaqgcc atgaacaatt 600
tgggttctgc cagcagggca cagct;gccgc c:ttctc<:cct gatagccact 650
acctcctctt tggggcccca ggaa<:ctata attggaaggg cacggccagg 700
gtggagctct gtgcacaggg ctcagcggac ctggcacacc tggacgac:gg 750
tccctacgag gcggggggag agaaggagca ggacc:cccgc ctcatcccgg 800
tccctgccaa cagctacttt ggct:ctcta ttgacac:ggg gaaaggtctg 850
gtgcgtgcag aagagctgag ctr.tgtggct ggagc:ccccc gcgccaacca 900
caagggtgct gtggtcatcc tgcg~~aagga cagcqccagt cgcctggtgc 950
ccgaggttat gctgtctggg gac~cgcctga cctcc:ggctt tggctactca 1000
ctggctgtgg ctgacctcaa cagtgatqgc tggc<:agacc tgatagtggg 1050
tgccccctac ttctttgagc gc~aagaaga gctggggggt gctgtgtatg 1100
280

CA 02421364 2003-03-25
tgtacttgaa ccaggggggt cacrgggctg ggatctcc:cc tctccggctc 1150
tgcggctccc ctgactccat gttcgggatc agcctggctg tcctggggga 1200
cctcaaccaa gatggctttc cagatattCC agtgggtgcc <:cctttgatg 1250
gtgatgggaa agtcttcatc taccatggc;a gc:agcc:tggg c~gttgtcgc:.~ 1300
aaaccttcac aggtgctgga ggg~:gaggct gtgggc;atca agagctt.cgg 1350
ctactccctg tcaggcagct tggatatgga tgggaaccaa t:accctgacc 1900
tgctggtggg caccctggct gacaccgc<g tgctci:tcag ggccagaccc: 1950
atcctccat.g tctcccatga ggtctctatt gctccacgaa gc:atcgacct 1500
ggagcagccc aactgtgctg gcggccactc ggtct<xtgtg gacctaaggg 1550
tctgtttcag ctacattgca gtccccagc:a gctat<~gc:cc tactgtggcc 1600
ctggactat:g tgttagatgc: ggacacagac cggaggctcc ggggccaggt 1650
tccccgtgtg acgttcctga gccgtaacvt ggaagaaccc aagca ccagg 1700
cctcgggcac cgtgtggctg aagcacca~;c atgaccgagt ctgtggagac 1750
gccatgttcc agctccagga aaatgtcaaa gacaagcttc gggccattgt 1806
agtgaccttg tcctacagt<: tccagacc-~c tcggctccgg cgacaggctc 1850
ctggccaggg gctgcca cca gtggcccc-~a tc:ca caat:gc ccaccagccc 1900
agcacccagc gggcagagat ccacttcctg aaqcaaggct gtggtgaaga 1950
caagatctgc cagagcaatc tgcagctggt ccacgcccgc ttctgtaccc 2000
gggtcagcga cacggaattc caacca ctgc ccatggatgt ggatggaaca 2050
acagccctgt ttgcactgag tgcgcagcca gtcattggcc tggagctgat 2100
ggtcaccaac ctgccatcgg acc:cagccca gccccaggct gatggggatg 2150
atgcccatga agcccagctc ctg gt:cat.gc ttc:ctgactc act.gcactac 2200
tcaggggtcc gggccctgga ccctgcggag aagccac:tct gcctgtccaa 2250
tgagaatgcc tcccatgttg agt.gtgagct ggggaacccc atgaagagag 2300
gtgcccaggt caccttctac ctcatcctta qcacctccgg gatcagcatt 2350
gagaccacgg aactggaggt agagctgctg ttggccacga tcagtgagca 2900
ggagctgcat ccagt:ctctg cac:gagcccg tgtcttcatt gagctgccac 2450
tgtccattgc aggaatggcc: at tccccagc aactcatctt ctct:ggtgtg 2500
gtgaggggcg agagagccat gcagtctc:ag cgggatgtgg gcagcaaggt. 2550
caagtatgag gtcacggttt ccaaccaagg ccagt:cgctc agaaccctgg 2600
gctctgcctt cctcaacat.c atgtggcca c atgagattgc caatgggaag 2650
28L

CA 02421364 2003-03-25
tggttgctgt acccaatgca ggttgagctg gagggcgggc aggggcctgg 2700
gcagaaaggg ctttgctctc ccaggc:ccaa c::atcctccac c:tggatgtgg 2750
acagtaggga taggaggcgg cgggagctgg agccacct:ga gcagcaggag 2800
cctggtgagc ggcaggagcc cagc:atgtcc tg~3tggccag t.gtcctctgc 2850
tgagaagaag aaaaacatca ccctggactg cgcccggggc acggccaaca 2900
gtgtggtgt.t cagctgccca ctct:acagct ttgacc:gcgc c~gctatgcta 2950
catgtctggg gccgtctctg gaac:agcacc tt.tctggagg agtaca cage 3000
tgtgaagtcc ctggaagtga ttgtccggctc caacat:caca gtgaagtcct 3050
ccataaagaa cttgatgctc cgacaatgcct ccacagtgat cccadtgatg 3100
gt.atacttgg accccatggc tgtggtggua gaagga gtgc cctggtgggt 3150
catcctcctg gctgtact.gg ctgggctgot ggt.gclvagca ~~tgcr_ggtgc: 3200
tgctcctgtg gaagatggga ttcttcaaa:~c gggcgaagca cc:ccgaggcc 3250
accgtgcccc agtaccatgc ggtgaagatt cctcgc~gaag accgacagca 3300
gttcaaggag gagaagacgg gcaccatc~:t gaggaacaac tggggcagcc 3350
cccggcggga gggcccggat gcacacccc::a tcctgc~ctgc tgacgggcat 3400
cccgagctgg gccccgatgg gcatccag<~g ccaggi:accg cctaggttcc 3950
catgtcccag cctggcctgt ggctgccctc cat.cccttcc ccagagatgg 3500
ctccttggga tgaagagggt agagtgggrt gca ggtgtcg catcaagatt 3550
tggcaggatc ggcttcctca ggc~gcacacXa cct:ctcccac ccacaagaac 3600
tcctcccacc caacttcccc ttagagtgct gtgagatgag agtgggtaaa 3650
tcagggacag ggccatgggq tagggtgaga agggcagggg tgtcctgatg 3700
caaaggtggg gagaagggat cctaatc.c:~t tcca ctccca ttcaccctgt 3750
gtaacaggac cccaaggacc tgc:ct.ccccg gaagtgcctt aacctagagg 3800
gtcggggagg aggttgtgtc actgactcag gcvtgctcctt ctctagtttc 3850
ccctctcatc tgaccttagt ttgctegccat cagtctagtg gtttcgtggt 3900
ttcgtctatt tattaaaaaa tat:ttgagaa caaaaaaaaa aaaaaaaaaa 3950
a 3951
<:210> 437
<211> 1141
<212> PRT
<213> Homo Sapiens
<400> 437
Met Ala G1y Ala Arg Ser Arg A:>p Yro Trp Gly Ala Ser Gly Ile
1 5 10 15
282
gggtcagcga cacggaattc caacca ctgc

CA 02421364 2003-03-25
Cys Tyr Leu Phe Gly Ser Leu Leu Val C>lu Leu L~eu Phe Ser Arg
20 25 30
Ala Val Ala Phe Asn Leu As_p Val Met Gly Ala Leu Arg Lys Glu
35 40 95
Gly Glu Pro G1y Ser Leu PI:e Gly Phe Ser Val Ala Leu His Arg
50 55 60
Gln Leu G.Ln Pro Arg Pro Gln Sex Trp Leu Leu Val Gly Ala Pro
b5 70 75
Gln Ala Leu Ala Leu Pro GLy Glr Gl.n Ala Asn Arg Thr Gly Gly
80 85 90
Leu Phe Ala Cys Prc_ Leu Ser Leu Glu Glu Thr Asp Cys Tyr Arg
95 100 105
Val Asp Ile Asp Gln Gly Al-a AsPMet- Gln Lys Glu Ser ~ys Glu
110 11~~ 120
Asn Gln Trp Leu Gly Va.1 Ser Val Arch Ser Gln C;ly Pro Gl.y Gly
125 130 135
Lys Ile Val Thr Cys Ala His Arc; Tyr Glu Ala Arg C~In Arg Val
190 145 150
Asp Gln Ile Leu Glu Thr Arg AsIMet Ile Gly Arg Cys Phe Val
155 16() 1.65
Leu Ser Gln Asp Leu A1a lle Arc; Asp Glu Leu Asp Gly Gly Glu
170 17w 180
Trp Lys F°he Cys Glu G1y Arg Pro Gln Gly His G1u (~ln Phe G1y
185 190 195
Phe Cys Gln G1n Gly Thr Ala Ala Ala Phf~ :>er Pro Asp Ser His
200 2G~~ 210
Tyr Leu Leu Phe Gly Ala Pro G1;~ Thr Tyr Asn Trp Lys Gly Thr
215 22J 225
Ala Ara Val Glu Leu C:ys Ala Gle: C~ly Ser Ala Asp Leu Ala His
230 23'; 290
Leu Asp Asp Gly Pro Tyr ClL Al:j Gly Gly Glu Lys Glu Gln Asp
245 250 255
Pro Arg .Leu Ile P.ro Val Fro Ala Asn Ser Tyr Phe Gly Phe Ser
260 265 270
Ile Asp Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe
275 280 285
Val Ala Gly Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile
290 295 300
Leu Arg Lys Asp Ser Aia :;er Arg Leu Val Pro Glu Val Met Leu
305 310 315
Ser Gly Glu Arg Leu Thr Ser Gly Fhe Gly Tyr Ser Leu Ala Val
320 325 330
28.

CA 02421364 2003-03-25
Ala Asp Leu Asn Ser Asp Gly Trp P.ro Asp heu 11e Val C)ly Ala
335 340 395
Fro Tyr Phe Phe G'lu Arg Gln Glu Glu Leu Gly Gly Ala Val Tyr
350 355 360
Val Tyr Leu Asn Cln Gly Gly Hi._= Trp Ala Gly lle Ser Pro Leu
365 37C 375
Arg Leu Cys Gly Ser Pro Asp Sex Met Fhe Gly lle Ser Leu Ala
380 38~~ 390
Val. Leu Gly Asp Leu Asn Gln Asp Gl;~ Phe~ Fro Asp Ile Ala Val
395 900 405
Gly Ala Fro Phe Asp Gly Asp Gly Lys Val Fhe lle Tyr His Gly
910 91'. 920
Ser Ser Leu Gly Val Val ALa LyPrc Sei; c~ln Val heu Glu Gly
425 430 935
Glu Ala Val G1y ile Lys Ser Phf: Gl y Tyr Ser Leu Ser t,1 y Ser
940 99': 450
Leu Asp Met Asp Gly Asn G1n Ty; Prc Asps Leu Leu Val Gly Ser
455 460 465
Leu Ala Asp Thr Ala Val Leu Ph<e Arg Ala Arg Pro Ile Leu His
470 47!=, 480
Val Ser His Glu Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu
48_°°. 490 995
Gln Prc Asn Cys Ala C~ly Gl.y Hi:~ Ser Val Cys Val Asp Leu Arg
500 505 510
Val Cys Phe Ser Tyr Ile Ala VaL F'ro Ser Ser Tyr Ser Pro Thr
~:15 520 525
val Ala Leu Asp Tyr Val Leu Asr~ Ala Asp Thr Asp Arg Arg Leu
5j~ 535 590
Arg Gly Gln Val Fro Arg Val Thr E'he Leu Ser Arg Asn Leu Glu
545 550 555
Glu Fro Lys His Gln Ala Ser Gly Thr Val Trp Leu Lys His Gln
560 565 570
His Asp Arg Val Cys Gly Asp Ala Met Phe Gln Leu Gln Glu Asn
575 580 585
Val Lys Asp Lys Leu Arg Ala Ile Val. Val Thr Leu Ser Tyr Ser
590 595 600
Leu Gln Thr Fro Arg Leu Jlrg Axg Glr: Ala Pro Gly Gln Gly Leu
605 b10 615
Pro Pro Val Ala Pro Ile Leu Asn A1,.3 His Gln Pro Ser Thr Gln
620 625 630
Arg Ala Glu Ile His Phe Leu Lys G:Ln Gly Cys Gly Glu Asp Lys
635 690 645
284

CA 02421364 2003-03-25
Ile Cys G.Ln Ser Asn Leu Gln Leu Val His Ala Arg Phe Cys Thr
6_'~0 fi55 660
Arg Val Ser Asp Thr Glu POe Gln Pro Leu Pro Met Asp Val Asp
665 670 675
Gly Thr Thr Ala Leu Phe Ala Leu Sei: Gly Gln Pro Val Ile Gly
680 tp85 690
Leu Glu Leu Met Val Thr Asn Leu Pro 5er Asp Pro Ala C~ln Pro
695 '700 705
Gln Ala Asp Gly Asp Asp A'~a His G.lu Ala C;ln lieu Leu Val Met
710 '715 720
Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro
'~25 730 735
Ala Glu Lys Fro Leu Cys L,eu Ser Asn Giu Asn 11.a Ser His Val
790 795 750
Glu Cys Glu Leu Gly Asn P.r.o Met Lys Arg Gly Ala Gln Val Thr
755 760 765
Phe Tyr Leu Ile Leu Ser Thr Sen Gly Ile ::er Lle Glu 'f'hr Thr
770 77'> 780
Glu Leu Glu Val Glu Leu Leu Lei.: Ala Thr Ile Ser c~lu Gl n Glu
785 790 795
Leu His Pro Val Ser Ala Arg Ala Arg Val Phe I1e Glu Leu Pro
800 80'. 810
Leu Ser I:le Ala Gly Met A1a I1<e Pro Gln Gln Leu Phe Phe Sex
815 820 825
Gly Val Val Arg Gly Glu Arg Ala Met G1=~ Ser Glu Arg Asp Val
830 83':, 89U
Gly Ser Lys 'Jal hys Tyr Glu VaL I'hr Val Ser Asn Gl.n Gly Gln
895 850 855
Ser Leu Arg Thr Leu Gly Ser Ala E'he Leu Asn I.le Met Trp Pro
860 865 870
His Glu ile Ala Asn Gly L.ys Trp Leu Leu Tyr Pro Met Gln Val
875 880 885
Glu Leu Glu Gly Gly Gln C;ly Pro G7y Gln Lys Gly Leu Cys Ser
890 895 900
Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser Arg Asp Arg
905 910 915
Arg Arg Arg Glu Leu Glu lero Pro Giu Gln Gln Glu Pro Gly Glu
920 925 930
Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu
935 990 995
Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg G1y Thr Ala Asn
950 9'_~5 960
GH_J

CA 02421364 2003-03-25
CysVai ValPheSerCysProLeufyrSer PheF~spArgAlaAla


965 970 975


ValLeu HisValfrpGlyAr-gLeu'frpAsn SerThrPheLeuGlu


980 9g5 990


GluTyr SerAlaValLysS<-.rLeisGll.iVal IleValArgAlaAsn


995 1000 1005


il.eThr ValLysSerSerIieLy:AsnLeu MetheuArgAspAla


1010 1015 1020


SerThr ValIleProValMetVa1TyrLeu AspProMetALaVal


1025 1030 1035


Va1ALa GluGlyValFroTrpTrp~Va1Il<=L,euLeuAlaVa1Leu


1090 7.045 1050


AiaGly LeuLeuValLeuAl.aLei.iLeuVa.1LeuLeuLeuTrpLys


1055 1060 1065


MetGIy PhePheLysArgAlaLy:,HisPro GluAiaThrValPro


1070 107 1080


GlnTyr HisAlaValLysIlePryArgGlu AspArgGlnGlnPhe


1085 1090 1095


LysGlu GluLysThrGly'fhrIlaLeuArg i~snAsnTrpGlySer


1100 7.105 1110


ProArg ArgGluGlyProAspAlaHisPro IleLeuAlaAlaAsp


1115 1120 1125


GlyHis ProGluLeuGLyProAsr%GIyHis Pr:oGlyProGlyThr


1130 1135 1140


Ala


<210> 938
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<:900> 938
ggctgacacc gcagtgctct tcag 29
<210> 939
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 439
28n

CA 02421364 2003-03-25
gctgctgggg actgcaatgt agcy 29
<210> 440
<211> 46
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-46
<223> Artificial Sequence
<400> 440
catcctccat gtctcccatg aggtctcte:~t tqctcc:ac:ga agcatc 96
<210> 941
<211> 1969
<212> DNA
<213> Homc> Sapiens
<400> 441
cgcgccgggc gcagggagct gagt.ggaccXg ctcgagac.gg cggcgcgtgc 50
agcagctcca gaaagcagcg agttggcaga gcaggc~ctgc atttccagca 100
ggagctgcga gcacagtgct. ggctcacaac aagatgctca aggtgtcagc 150
cgtactgtgt gtgtgtgcag ccgcttgg~ag cagtca gtct ctcgcagctg 2U0
ccgcggcggt ggctgcagcc ggggggcggt cggacggcgg taattttctg 250
gatgataaac aatggctcac cacaatct~:t caatatgaca aggaagtcgg 300
acagtggaac aaattccgag acgaagtaga ggatgattat ttccgcactt 350
ggagtccagg aaaacccttc gatcaggctt tagatccagc taaggatcca 900
tgcttaaaga tgaaatgtag tcgccataaa gtatgcatt.g ctcaagat.tc 450
tcagactgca gtctgcatta gtc:ac:cgg.ag gcttacacac aggatgaaag 500
aagcaggagt agaccatagg cagtggaggg gtc:ccatatt atccacctgc 550
aagcagtgcc cagtggtcta tccvcagccct gtt=tgtggtt cagatggt:ca 600
tacctactct tttcagtgca aactagaata tcaggcatgt gtcttaggaa 650
aacagatctc agtcaaatgt gaaggacatt gcc:cat.gtcc ttcagataag 700
cccaccagta caagcagaaa tgt.taagaga qcatgcagtg acctggagtt 750
cagggaagtg gcaaacagatt.gcgggac:tg gttcaaggcc cttcatgaaa 800
gtggaagtca aaacaagaag acaaaaacat tgctgaggcc tgagagaagc 850
agattcgata ccagc:atctt gcc:aatttgc aaggactcac ttggctggat 900
gtttaacaga cttgatacaa actatgacct gctattggac cagtcagagc 950
tcagaagcat ttaccttgat aagaatg<;ac agtgt:accaa ggcattcttc 1000
aattcttgtg acacatacaa ggacagtt.ta atatc:taata atgagtggtg 1050
287

CA 02421364 2003-03-25
ctactgcttc cagagacagc aagcicc;cacc tt gcc~.gact ctagctcagca 1100
atattcagaa gcggcaaagg gtoaaclaaac tcctaqgac<-i cttataaccc:c 1150
ctgtgtgatg aagatggtta cta~:~a~sgcca acacaatc~tc atggc:agtgt 1200
tggacagtgc tggtgtgttg acagatatc:g aaatgaaatc atgggatcca 1250
gaataaatgg tgttgcagat tgtg ctatag attttgagat ctccggagat 1300
tttgctagtg gcgattttca tgaatggaot gatgat:gagg atgat:gaaga 1350
cgatattat.g aatgatgaag atgaaattga agatgatgat gaagatgaag 1400
gggatgatga tgatggtggt gatc~accat.g atgtatacat ttgattgatg 1950
acagttgaaa tcaataaatt ctacatttct aatatr.taca aaaatgatag 1500
cctatttaaa attatcttct.. tccccaataa caaaatgatt ctaaacctca 1550
catatatttt gtataattat ttgaaaaatt gcagctaaag tt:atagaact 1600
ttatgtttaa ataagaatca tttgctttra gtt.tttatat tccttacaca 1650
aaaagaaaat acatatgcag tctagtcaga caaaataaag ttttgaagtg 1700
ctactataat aaatttttca cgagaacaaa ct:t:tgtaaat cttccataag 1750
caaaatgaca gctagtgc:tt gggatcgtac atgttaatt.t tttgaaagat 1800
aattctaagt gaaatttaaa ataaataa:~t ttttaatgac ctgggtctta 1850
aggatttagg aaaaatatgc atgct:ttaat tgcatttcca aagtagcatc 1900
ttgctagacc tagatgagtc agrataacag agagatacca catgactcca 1950
aaaaaaaaaa aaaa 1969
<210> 942
<211> 936
<21.2> PRT
<213> Homo sapiens
<400> 442
Met Leu Lys Val Ser Ala Va1 Le~u Cys Val Cys Ala Ala Ala Trp
1 5 10 15
Cys Ser Gln Ser Leu Ala Al,s Ala A1<~ A7a Val Ala Ala Ala Gly
20 25 30
Gl.y Arg Ser Asp Gly Gly Asn Pt:e Leu A:;p Asp Lys Gln Trp Leu
35 40 95
Thr Thr Il.e Ser Gln Tyr Asp Lys Glu Va1 Gly Gln Trp Asn Lys
50 _'~5 60
Phe Arg Asp Glu Vai Glu Asp A:>p Tyr Phe Arg Thr Trp Ser Pro
65 70 75
Gly Lys Pro the Asp Gln Ala Lt:~u Asp Pro Ala Lys Asp Pro Cys
80 ,5 90
Leu Lys Met Lys Cys Ser Arg His Lys Val Cys Ile Ala Gln Asp
288

CA 02421364 2003-03-25
G5 100 105
Ser Gln Thr Ala Val Cys Iie Ser His Arg Arg Leu Thr His Arg
110 L15 120
Met Lys GIu Ala Gly Val Asp His Arg Gln Trp Arg Gly Pro Ile
125 13C 135
Leu Ser Thr Cys Lys Gl.n Cys Prc Vai Val Tyr I'ro Ser Pro Val
140 14'. 150
Cys Gly Ser Asp Gly His Thr Tyr Ser Phe Gln Cys Lys Leu Glu
I55 16C) 165
Tyr Gln Ala Cys Val Leu Gly Lye G1:~ Ile Ser Val hys (~ys Glu
170 175 180
Gly His Cys Pro Cys Pro Ser Asp Lys Pro T hr :per Thr Ser Arg
185 19(.~ 195
Asn Val Lys Arg Ala Cys Ser Ash Leu Glu I'he Arg ('~lu Val Ala
zoo 2 c~-, 210
Asn Arg Leu Arg Asp Trp Fhe Lys Ala Leu His Glu Ser Gly Ser
27.5 220 225
Gln Asn Lys Lys Thr Lys Thr Le,a Leu Arg I'ro Glu Arg Ser Arg
230 235 240
Phe Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp
245 250 255
Met Fhe Asn Arg Leu Asp Thr Asn Tyr Aso Leu Leu Leu Asp Gln
260 265 270
Ser Glu Leu Arg Ser Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr
275 280 285
Lys Ala Phe Phe Asn Ser Cys Asp 'I'hr Tyr Lys Asp Ser Leu Ile
290 295 300
Ser Asn Asn Glu Trp Cys Tyr Cys Phe Gln Arg Gln Gln Asp Pro
30'~ 3I0 315
Pro Cys Gln Thr Glu I_,eu Ser Asn ile Gl.n Lys Arg Gln Gly Val
32(7 325 330
Lys Lys Leu Leu Gly Gin "'yx: Ile Pro Leu Cys Asp Glu Asp Gly
335 340 345
Tyr Tyr Lys Pro Thr Gln Cy:: His Gly Ser Val Gly Gln Cys Trp
350 355 360
Cys Val Asp Arg Tyr Gly flSI7 Glu Val Met Gly Ser Arg Ile Asn
36'> 3i0 375
Gly Val Ala Asp Cys Ala Tle Asp Phe Glu Ile Ser Gly Asp Phe
380 38,5 390
Ala Ser Gly Asp Fhe His c:;lu Txp Thr A;~p Asp Glu Asp Asp Glu
395 400 405
Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu Asp Asp Asp Glu
28!?

CA 02421364 2003-03-25
910 915 420
Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His Asp Val Tyr
925 ~3C 935
lle
<210> 493
<211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial Sequence
<400> 443
cagcaatatt cagaagcggc aaggg 25
<210> 999
<211> 28
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-28
<223> Artificial Sequence
<400> 444
catcatggtc atcaccacca tcatcatc 28
<210> 445
<211> 48
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-98
<:223> Artificial Sequence
<900> 995
ggttactaca agccaacaca atgtcatgg c agtgttggac agtgctgg 98
<210> 946
<211> 3617
<212> DNA
<:213> Homo sapiens
<900> 446
cagactccag atttccctgt= caa ccacgag gagtc;cagag aggaaacgcg 50
gagcggagac aacagtacct~ gacgcctctt tcagc:ccggg atcgccccag 100
cagggatggg cgacaagatc tggctgccct tcccc:gtgct ccttctggcc 150
gctctgcctc cggtgctgct= gccagggqcg gccgc~ct:tca c.accttccct 200
cgatagcgac ttcaccttta cccttccc:gc cggcc~agaag gagtgcttct 250
290

CA 02421364 2003-03-25
accagcccat gcccctgaag gcctcgctgg agatcgagta ccaagtttta 300
gatggagcag gatt.agatat tgatttccat ctt.c~cctct.r cagaaggcaa 350
aaccttagtt tttgaacaaa gaaaat;caga t=ggagt.tc:ac actgtagaqa 400
ctgaagttgg tgattacatg ttctgc:tttg aca<3tacatt cagcaccatt 450
tctgagaagg tgattttctt tgaattaatc ctggataata t:.gggagaar_a 500
ggcacaagaa caagaagatt ggaagaaata tattactc~gc <,icagatatat 550
tggatatgaa actggaagac atcctggaat ccatcaac:ag <;atcaagt<;c 600
agactaagca aaagtgggca catacaaatt ctgcttacaag c:atttgaagc 650
tcgtgatcga aacatacaaq aaagcaactt tgatagagtc aatttctggt 700
ctatggttaa tt,tagtggtc atggtggtgg tgtcagccat tcaagtttat 750
atgctgaaga gtctgtttga agataagac_ag aaaagt..agaa ~ataaa«ct:c 800
caaactagag tacgtaacat tgaaaaatga ggcat<iaaaa ~gcaataaac 850
tgttacagtc aagaccatta atggtctt<a ccaaa<statt ttgagatata 900
aaagtaggaa acaggtataa ttttaatgt_g «aaat~..aagt cttcactttc 950
tgtgcaagta atcctgctga tccagttgta cttaagtgtg taacaggaat 1000
attttgcaga atataggttt aac:tgaatga agccatatta ataa~ctgcat 1050
tttcctaact ttgaaaaatt ttgcaaat~xt ctt.aggtgat ttaaataaat 1100
gagtattggg cct:aattgca acaccagtat gtt.tttaaca ggttctatta 1150
cccagaactt ttttgtaaat gcggcagtt:a caaattaact gtggaagttt 1200
tcagttttaa gttataaatc ac<vtgagaat tac:ctaatga tggattg«at 1250
aaatctttag actacaaaag cccaactttt ctca atttac atatgcatct 1300
ctcctataat gtaaatagaa taatagcttt ga<iatacaat taggtttttg 1350
agatttttat aaccaaatac at.tt<;agtgt aacatattag cagaaagcat 1400
tagtctttgt actttgctta cat.t<:ccaaa agctgacatt ttc«cgattc 1450
ttaaaaacac aaagttacac t.tact:aaaat taggacatgt tttctctttg 1500
aaatgaagaa tatagtttaa aagcttcctc ctccataggg acacattttc 1550
tctaaccctt aactaaagtg taggatttta aaattaaatg tgaggtaaaa 1600
taagtttatt tttaatagta tctg-:.caagt taatatc.tgt caacagttaa 1650
taatcatgtt atgttaattt taacatgatt gctgacttgg ataattcatt 1700
attaccagca gttatgaagg aaatattgct aaaat:gatct gggcctac:ca 1750
taaataaata tctccttttc tgagctct.aa gaatt:at:cag aaa«caggaa 1800
agaatttaga aaaacttgag aaaa:cctaat ccaaaataaa att:cacttaa 1850
29t

CA 02421364 2003-03-25
gtagaactat aaataaatat ctagaatctg actggcacat <:atgacatc~c 1900
tactcataac ataaatcaaa ggagatgatt aatttc:cagt tagctggaag 1950
aaactttggc tgtaggtttt tatt:ttctac aagaattctg c~tttgaatta 2000
tttttgtaag caggtacatt ttataaaat g taagc<:ctac i=gtaaggttt 2050
agcactgggt gtacatattt attaaaaatt tttati_atas caactttt.at 2100
taaaatggc:c tttctgaaca ctttatttat tgatgttgaa gtaaggatta 2150
gaaacataga ctcccaagtt ttaaacacc.;t aaatg=gaat ~aacccatata 2200
tacaacaaag tttctgccat ctagcttttt= gaagtctatg ggggtcttac: 2250
tcaagtacta gtaatttaa<: ttcatcatga atgaa~aata atttttaagr_ 2300
tatgcccatt tataacgttg ttt.atgacaa cattgtgagt tagaaacaaa 2350
cttaaaattt ggggtataga acc:cctcaac aggttagtaa tgctggaatt 2900
cttgatgagc aataatgata accagagagt g<~t.ttcat.tt ac:actcatag 2450
tagtataaaa agagatacat ttc:cctctta ggc:ccctggg agaagagc:ag 2500
cttagatttc cctactggca aggtt.tttaa aaatgaggta aatgccgtat 2550
atgatcaatt accttaattg gccaagaaaa tgc:ttcaggt gtctaggggt 2600
atcctctgca acacttgcag aac:aaaggt.c aat=aagatcc ttgcctat.ga 2650
atacccctcc cttttgcgct gtta<iattt=.g caatgagaag caaatttaca 2700
gtaccataac taataaagca gggtacagat ataaactact gcatcttttc 2750
tataaaactg tgattaagaa ttctacctct cctgtatggc tgttactata 2800
ctgtactctc tgact:cctta cctaacaatg aatttgt-tac ataatctrct 2850
acatgtatga tttgt.gccac: tgatc:ttaaa cctatgattc agtaacttct 2900
taccatataa aaacgataat tgc;tttattt ggaaaagaat ttaggaatac 2950
taaggacaat tatttttata gacaaagtaa aaagacagat atttaagagg 3000
cataaccaaa aaagcaaaac ttgtaaa<:ag agt:aaaaatc tttaatattt 3050
ctaaagacat actgttt.atc tg~.:ttcat.at gcttt=tttta att.tcactat 3100
tccatttcta aattaaagtt atgctaaactt gagta agog tttatca:~tt 3150
aacagctcat. tttgtctttt tcaatataca aattl~taaaa atactacaot 3200
atttaactaa ggcccaaccg atttccat:.aa tgtagcagtt accgtgttc:a 3250
cctcacacta aggcctagag tttgctct..ga tatg~~atttg gatgattaat= 3300
gttatgctgt tctttcatgt gaatgtcaag acatggaggg t=gtttgtaat 3350
tttatggtaa aattaatcct tcttacacat aatggtgtct taaaattgac 3900
292

CA 02421364 2003-03-25
aaaaaatgag cacttacaat tgtc~tgtctc ctcaaatgaa gattctttat 3950
gtgaaatttt aaaagacatt gattccgcat gtaaggattt t.tcatctgasa 3500
gtacaataat gcacaatcag tgttgctcaa actgcttt.at acttataaac 3550
agccatctta aataagcaac gtattgtgag tactgatatg t.atataataa 3600
aaattatcaa aggaaaa 3617
<21C> 997
<211> 229
<212> PRT
<21:.~> Homc: Sapiens
<400> 497
Met Gly Asp Lys Ile T.rp Leu Pro Phe Pro Val Leu Leu Len Ala
15
Ala Leu Fro Pro Val. Leu Leu Pr~:~ Gl.y Ala Ala Gly Phe Thr Pro
25 30
Ser Leu Asp Ser Asp Phe Thr Pht:~ Thr Leu Pro A1a Gly Gln Lys
35 40 45
Glu Cys Phe Tyr Gln Prc Met Prro Leu Lys Ala Ser Leu Glu Ile
SO 55 60
Glu Tyr Gln Val Leu Asp Gly Ala Giy Leu Asp I1e Asp Phe His
65 70 75
Leu Ala Ser Pro Glu Gl.y Lys Thr Leu Val Phe Glu Gln Arg Lys
80 85 90
Ser Asp Gly Val His Thr Vat. G7u Thr Glu Val Gly Asp Tyr Met
95 100 105
Phe Cys Phe Asp Asn Thr Phe Ser Thr Ile Ser Glu Lys Val Ile
110 115 120
Phe Phe Glu Leu Ile Leu Asp ASn Met Gly Glu Gln Ala Gln Glu
12'_u 130 135
Gin Glu Asp Trp Lys Lys 'ry~° Ile 'Phr Gly Thr Asp Ile Leu Asp
190 195 150
Met Lys Leu Glu Asp Ile :,eu G7u Ser Ile Asn Ser Ile Lys Ser
155 1E>0 165
Arg Leu Ser Lys Ser Gly His I~e Gln I7.e Leu Leu Arg Ala Phe
170 l.'s 180
Glu Ala Arg Asp Arg Asn Ile Gin Glu Ser Asn Fhe Asp Arg Val
185 1~a0 195
Asn Phe Trp Ser Met Val Asn Lc-'u Val Val Met. Val. Val Val Ser
200 205 210
Ala Ile Gln Val Tyr Met Leu Lys Ser Lc=u Phe Glu Asp Lys Arg
215 220 225
Lys Ser Arg Thr
293

CA 02421364 2003-03-25
~~210> 948
<211> 23
<212> DNA
<:'l'j> P.rtificia;
<:220>
<221> Artificial Sequence
<222> 1-23
<~223> Artificial Sequence
<400> 948
cccagcaggg ctgggcgaca aga 23
<210> 499
<211> 23
<21.2> DNA
<213> Artificial
<220=>
<221> Artificial Sequence
<222> 1-23
<223> Artificial Sequence
<400> 449
gtcttccagt ttcatatcca ata 23
<210> 950
<211> 93
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-43
<223> Artificial Sequence
<400> 450
ccagaaggag cac:ggggaag ggc:agccaga tc_~ttgtc:gcc cat 4 3
<210> 451
<211> 859
<212> DNA
<213> Homo Sapiens
<900> 451
ccatccctga gatcttttta taaaaaaccc agtctttgct gaccagacaa 50
agcataccag atctcaccag agagtcgcag acact.atgct gcct_cccatg 100
gccctgccca gtgtgtcctg gatgctgctt tcctgcctca ttct.cctgtg 150
tcaggttcaa ggtgaagaaa cccagaar.ga actgc:cctct ccac:ggatca 200
gctgtcccaa aggctccaag gcctatgcrct cccccagcta tgcc:ttgttt 250
ttgtcacc:aa aatcctggat ggatgcacrat ctgg<vttgcc agaagcggcc 300
ctctggaaaa ctggtgtctg tgctcag=gg ggctgaggga tccttcgr_gt 350
cctccctggt gaggagcatt agtaaca~~ct actcatacat ctggattggg 900
ctccatgacc ccacacaggg ctc:tgagcct gatggagatg gatg ggagtg 950
294

CA 02421364 2003-03-25
gagtagcact gatgtgatga attactttgc atgggagaaa aatccctcca 500
ccatcttaaa ccctggccac tgtclggagcc tgt.caagaag cacaggattt 550
ctgaagtgga aagattataa ctgtgatgca aagttaccct aitgtctgcaa 600
gttcaaggac tagggcaggt gggaagtcag cagcct.cagc t_tggcegtge:a 650
gctcatcatg gacatgagac cagt:.gtga~zg act=caccctg daagagaata 700
ttctccccaa actgccctac ctgactacc~t tgtcat.gatc ca ccttcttt 750
ttcctttttc tt.caccttca tttcaggcit ttctct:gtct tccatgtctt 800
gagatctcag agaataataa taaaaatg~t actttataaa aaaaaaaaaa 850
aaaaaaaaa 859
<2i0> 952
<211> 175
<2i2> PRT
<213> Homc.~ sapiens
<400> 452
Met Leu Pro Pro Met. Al.a L,eu Pro Ser Val Ser Trp Met Leu Leu
1 5 10 15
Ser Cys Leu Ile Leu Leu (:'ys Gln Val Gln Gl.y G1u Glu Thr Gln
20 25 30
Lys Glu Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys
35 40 95
Ala Tyr Gly Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser
50 55 60
Trp Met Asp Ala Asp Leu Ala Cys Gln Lys Arg Fro Ser Gly Lys
65 70 75
Leu Val Ser Val Leu Ser Gly Ana Glu Gly Ser Phe Val Ser Ser
80 E',5 90
Leu Val Arc Ser Iie Ser .Asn S<-~r Tyr Se:r Tyr Ile Trp Ile Gly
G5 1 ()0 105
Leu His Asp Fro Thr Gln Gly Ser Gl.u Pro Asp Gly Asp Gly Trp
1i0 1'15 120
Glu Trp Ser Ser Thr Asp Val Mot Asn Tyr Phe Ala Trp Glu Lys
i25 130 135
Asn Pro Ser Thr Ile Leu Asn Pro Gly His Cys Gly Ser Leu Ser
140 145 150
Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp Tyr Asn Cys Asp Ala
155 160 7.65
Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp
170 175
<210> 953
<211> 550
295

CA 02421364 2003-03-25
<212> DNA
<213> Homo Sapiens
<900> 453
ccagtctgtc gccac:ctcac: ttgg~gtctg ctgtccccgc caggcaagcc 50
tggggtgaga gcacagagga gtggc~ccggg accatgcggg ggacgcggct 100
ggcgctcctg gcgctggtgc tggctgcctg cggagagctg gcgccggccc 150
tgcgctgcta cgtctgtccg gacacccacag gagtgtcgga ctgtgtcacc 200
atcgccacct gcaccaccaa cgaaaccatg t:gcaagacca cactctactc 250
ccgggagata gtgtacccct tcc:aggggga ctc:cacggtg accaagtcct 300
gtgccagcaa gtgtaagccc tcgg<itgtgg atggcatcgg ccagaccc:tg 350
cccgtgtcct gctgcaatac tgagctgtgc aatgtagacg gggcgcccgc 900
tctgaacagc ctccactgcg gggccctcac gctcctccca ctcttgaqcc 450
tccgactgta gagtccccgc ccacccccat ggccctatgc ggcccagccc 500
cgaatgcctt gaagaagtgc ccc:ctgcacc aggaaaaaaa aaaaaaaaaa 550
<210> 959
<211.> 125
<2i2> PRT
<213> Homo sapiens
<900> 959
Met Arg Gly Thr Arg Leu Ala Le~.~ Leu Ala Leu Val Leu Ala Ala
1 ' 10 15
Cys Gly G1n Leu Ala Pro Ala Leu Arq Cys Tyr Val Cys Pro G1u
20 25 30
Pro Thr Gly Val Ser Asp Cys Val Thr Ile Ala Thr Cys Thr Thr
~5 40 95
Asn G1u 'Chr Met Cys Lys Thr The Leu Tyr Ser Arg Glu Ile Va1
50 55 60
Tyr Pro Phe Gln Gly Asp Ser Thr Val Thr Lys Ser Cys Ala Ser
65 70 75
Lys Cys Lys Pro Ser Asp Val Asp Gly Ile Gly Gln Thr Leu Pro
80 85 90
Va1 Ser Cys Cys Asn Thr Glu Leu Cys Asn Val Asp Gly Ala Pro
95 100 105
Ala Leu Asn Ser Leu His C'ys Gl~~ Ala Leu Thr Leu Leu Pro Leu
110 115 120
Leu Ser Leu Arg Leu
l~~
<210> 455
<211> 1518
<21.2> DNA
<213> Homo Sapiens
296

CA 02421364 2003-03-25
<9co> 455
ctgcagtcag gactctggga ccgcaggggg ctccc.ggac c ctgactctgc 50
agccgaaccg gcacggtttc gtggggaccc aggcttgcaa agtgacggtc 100
attttctctt tctttctccc tcitctagtcc ttctgagatg atggctctgg 15C
gcgcogcggg agctacccgg gtc_:tt:tgtcg c:gatggtagc ggcggctcac 200
ggcggccacc ctctgctggg agtgagcgcc accttgaact cggttctcaa 250
ttccaacgct atcaagaacc tgcccccacc gctgggcggc gctgcggggc 300
acccaggctc tgcagtcagc gccgcgccgg gaatcctgta cccgggcggg 350
aataagtacc agaccatt.ga caactaccag ccgtacccgt gcgcagagga 400
cgaggagtgc ggcactgatg agtactgcgc tagtcccacc cgcggagggg 450
acgcaggcgt gcaaatctgt ctcgcctgca ggaagcgccg aaaacgctgc 500
atgcgtcac g ctatgtgctg ccccggga:~t tactgcaaaa atggaatatg 550
tgtgtcttct gatcaaaatc atttccgagg agaaat.tgag gaaaccatca 600
ctgaaagctt tggtaatgat catagcac<a tggatgggta ttccagaaga 650
accaccttgt cttcaaaaat gtatcacac:c aaaggacaag aaggttctgt 700
ttgtctccgg tcatcagact gtgcctcagg attgtgttgt gct.agacact 750
tctggtccaa gatctgtaaa cct:gtcct::3a aagaaggtca agtgtgtacc 800
aagcatagga gaaaaggctc tcatggacta gaaat,attcc agcgttgtta 850
ctgtggagaa ggtctgtctt gccggataca gaaagatcac catcaagcca 900
gtaattcttc taggcttcac acttgtcaga gacactaaac cagct.atcca 950
aatgcagtga actcctttta tataatagat gctatgaaaa ccttttatga 1000
ccttcatcaa ctcaatccta aggatatac::a aqttctgtgg tttcagttaa 1050
gcattccaat aacaccttcc: aaaaacctcrg agtgtaagag ct:ttgtttct 1100
ttatggaact cccctgtgat tgcagtaaat tactgtattg taaattctca 1150
gtgtggcaca tacctgtaaa tgcaatgaa:~a cttttaatta tttttct.aaa 1200
ggtgctgcac tgcctatttt, tcctcttgtt: atgta<iattt ttgtacacat 1250
tgattgttat cttgactgac aaatattcta tattgaactg aagtaaatca 1300
tttcagctta tagttcttaa aagcataa<:c cttt.ac cc.ca -ttaattcta 1350
gagtctagaa cgcaaggatc tcttggaatg acaaatgata ggtacctaaa 1900
atgtaacatg aaaatact.ag cttattttct gaaatgtact atcttaatgc: 195C
ttaaattata tttcccttta ggctgtgat.a gttttt:gaaa taaaatttaa 1500
catttaaaaa aaaaaaaa 1518
?_97

CA 02421364 2003-03-25
<210> 956
<211> 266
<212> PRT
<213> Homo Sapiens
<900> 956
Met Met Ala Leu G1y Ala Ala Gly Ala Thr Arg Val Fhe Val Ala
i ~ 10 15
Met Val Ala Ala A1a Leu Gly Gly His Pro Leu Leu Gly Val Ser
20 25 30
Ala Thr Leu Asn Ser Val Leu AsrSer Asn Ala Ile Lys Asn Leu
35 90 95
Pro Fro Pro Leu Gly Gly P.la Ai.a Gly His Pro Gly Ser Ala Val
50 55 60
Ser Ala Ala Pro Gly Ile Leu Tyr Frc Gly Gly Asn Lys Tyr Gln
65 70 75
Thr Ile Asp Asn Tyr Gln F'ro Tyr Pro Cys Ala Glu Asp Glu Glu
80 85 90
Cys Gly Thr Asp Glu Tyr ('ys Ala Ser Pro Thr Arg Gly Gly Asp
95 100 105
Ala Gly Val Gln Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg
11G 115 120
Cys Met Arg His Ala Met Cys Cys Frc: Gly Asn Tyr Cys Lys Asn
125 130 135
Gly Ile Cys Val Ser Ser Asp Gln Asn His Phe Arg Gly Glu Ile
190 195 150
Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn Asp His Ser Thr Leu
155 160 165
Asp Gly 'yr Ser Arg Arg Thr Th_ Leu Ser Ser Lys Met Tyr His
170 1.7.~ 180
Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys
185 190 195
Ala Ser Gly Leu Cys C:ys Ala Arca His Php '1'rp Ser Lys Il.e Cys
200 20.'~ 210
Lys Pro Val Leu Lys G.lu Gl.y Glm Val Cy;~ I'hr Lys His Arg Arg
21' 220 225
Lys Gly Ser His Gly L~eu Glu Ilf, Phe Gln Arg Cys Tyr Cys Gly
230 23.'5 290
Glu Gly Leu Ser Cys Arg Ile Glr: Lys Asp His His Gln Aia Ser
29' 250 255
Asn Ser Ser Arg Leu His Thr Cy: Gin Arc3 His
260 265
<210> 957
<211> 638
298

CA 02421364 2003-03-25
<212> DNP.
<213> Homo sapiens
<220>
<221> unsure
<222> 30, 123, 133, 139, 180, a:14, 259, 282, 308, 95'2, 967, 471, 973,
509, 556
<223> unknown base
<400> 457
tgtgtttccc tgcagtcaga atttgggacn gcaggggttc ccggacctga 50
ttttgcagcg gaacgggaag gtttrgtc~gg acccaggttg aaatgacc~gt 100
catttttttt tctttctcct tcnggagtcc ttntgagang atggttttgg 150
gcgcagcggg agctaacccg gtt-ttttgtn gcgat.ggtag cggcggtttt 200
cggcggccac cttntgctgg gagtgagcgc caccttgaat cggttttcaa 250
ttccaacgnt atcaagaacc: tgcccccacc gntgggcggc gctgcggggc 300
acccaggntt tgcagtcagc gccgcgccgg gaatcctgta cccgggcggg 350
aataagtacc agaccattga caatt=accag ccgtacc:cgt gcgcagagga 400
cgaggagtgc ggcactgatg agtactgcgc tagtcccacc cgcqgagggg 450
angcgggcgt gcaaatntgt ntragcct.gca ggaagcgccg aaaacgctgc 500
atgcgtcang ctatgtgctg ccccgggaat tactgcaaaa atggaatatg 550
tgtgtnttct gatcaaaatc atttccgagg agaaattgag gaaacc:atca 600
ctgaaagctt tggtaatgat catagcacct tggatggg 6r'.8
<210> 458
<211> 4040
<212> DNA
<213> Homo sapiens
<400> 458
gaggaaccta ccggtaccgg ccgcgcqctg gtagtcgccg gtgtggctgc 50
acctcaccaa tcccgtgcgc cgcggctggg ccgtcggaga gtgcgtgtgc 100
ttctctcctg cacgcggtgc ttaggctcgg ccaggcgggg tccgccgc:ca 150
gggtttgagg atgggggagt agctacagga aqcgaccccg cgatggcaag 200
gt:atattttt gtggaatgaa aacrgaagtat tagaaatgag ct:gaagac:ca 250
ttcacagatt aatatttttg gggacagatt tgtgatgctt gattcaccct 300
tgaagtaatg tagacagaag ttctcaaat:t tgcatattac atcaactgga 350
accagcagtg aatcttaatg ttcacttaaa tcagaacttg cataagaaag 400
agaatgggag t~tggttaaa taaagatgac t.<3t=atcagag acttgaaaag 950
gatcattctc tgttttctga tagtgtatat ggccatttta gtgggcacag 500
atcaggattt ttacagttta cttggagtgt c.caaaactgc aagcagtaga 550
'299

CA 02421364 2003-03-25
gaaataagac aagctttcaa gaaattgoca ttgaagttac atcctgataa 600
aaacccgaat aacccaaatg cacatggoga t:tttt taaaa ataaatagag 650
catatgaagt actcaaagat gaagatctac ggaaaaagta tgacaaatat 700
ggagaaaagg gacttgagga taat~~aaqgt ggccagtat:g aaagctggaa 750
ctatt:atcgt tatgattttg gtatttatga tgatqatcct gaaatcat=aa 800
cattggaaag aagagaattt gatgctgc:tg ttaatt<:tgg agaactgtgg 850
tttgtaaatt tttactcccc aggctgttca cactgccatg atttagctcc 900
cacatggaga gactttgcta aa:~aagtGga tgggttactt cgaattgqag 950
ctgttaactg tggtgatgat aga atgcttt qccgaatgaa aggagtcaac 1000
agctatccca gtctcttcat ttttcggtct ggaatggccc cagtgaaata 1050
tcatggagac agatcaaagg aga gtttagt gagttttgca atgcagcatg 1100
ttagaagtac agtgacagaa cttt<xgacag qaaattttgt caactccata 1150
caaactgctt ttgctgctgg tattggctgg ctgatcactt tttgttcaaa 1200
aggaggagat tgtttgactt cacagacacg actcaggctt agtggcatgt 1250
tgtttctcaa ctcattggat gcta<jagaaa tat=atttgga agtaatac:at 1300
aatcttccag attttgaact actttcggca aacacactag aggatcgttt 1350
ggctcatcat cggtggctgt tattt:ttt~a ttt=tggaaaa aatgaaaatt 1900
caaatgatcc tgagctgaaa aaactaaaaa ctctacttaa aaatgatcat 1450
attcaagttg gcaggtttga ctgttcctct gcaccaqaca tctgtagtaa 1500
tctgtatgtt tttcagc:cgt ct<:tagcagt at.ttaaagga caaggaacca 1550
aagaatatga aattcatcat ggaaagaaga ttca atatga tatacttgcc 1600
tttgccaaag aaagtgtgaa ttctcatgtt accacgcttg gacctcaaaa 1650
ttttcctgcc aatgacaaag aac:catggct tgttgatttc tttgccccct: 1700
ggtgtccacc atgtcgagct ttactaccag agt:tacgaag agcatcaaat 1750
cttctttatg gtcagcttaa gtttggtaca ctagattgta cagttcatga 1800
gggactctgt aacatgtata acattcagcxc ttatccaaca acagtggtat 1850
tcaaccagtc caacattcat gagtatgaag gacatcactc tgctgaacaa 1900
atcttggagt tcatagagga tcttatga~t ccttc~~gtgg tctcccttac 1950
acccaccacc ttcaacgaac tagttaca<;a aagaaaacac aacgaagtct 2000
ggatggttga tttctattct ccgtggtgr_c atccttgcca agtcttaatg 2050
ccagaatgga aaagaatggc ccggacatva actggactga tcaacgtggg 2100
300

CA 02421364 2003-03-25
cagtatagat tgccaacagt atcattcttt ttgtgcccag gaaaacgttc 2150
aaagataccc tgagataaga ttttttcccc c:aaaatcaaa taaagcttat 2200
cagtatcaca gttacaatgq tt-~gaatag9 qatgcttatt c:cctgagaat 2250
ctggggtcta ggatttttac ctcaagtatc cacaqatcta acacctcaaa 2300
ct:ttcagtga aaaaqttct<i caagg ga<:aa atcattqgqt gattgatt.tc 2350
tatgctcctt ggtgtggacc ttgccagaat tt=tgctccag aatttgagct 2400
cttggctagg atgattaaag gaaaagtaaa agctqgaaaa gtaqactgtc 2950
aggcttatgc: tcagacatgc caqaaagctg ggatcagggc ctatccaact 2500
gttaagtttt atttctacga aaqagcaaag agaaattttc aagaagagca 2550
gataaatacc agagatgcaa as<~caatcgc tqccttaata agtgaaaaat 2600
tggaaactct ccgaaatcaa ggc:aagagga ataaggatga actttgataa 2650
tgttgaagat gaagaaaaaq tttaaaagaa attctgacag atgacatcag 2700
aagacaccta tttagaatgt tacatttatg atgggaatga atgaacatta 2750
tcttagactt gcagttgtac tgccagaatt atctacagca ctggtgtaaa 2800
agaagggtct gcaaactttt tctgt:aaagg gccggtttat aaatatttta 2850
gactttgcag gctataatat atggttcaca catgagaaca agaatagagt 2900
catcatgtat tctttgttat tt:~ct:tttaa c:aaccttt.aa aaaatattaa 2950
aacgattctt agctcaqagc catac:aaaag taggctqgat tcagtccatg 3000
gaccatagat tgctgtcccc ctcgacggac ttataatgtt tcaggtggct 3050
ggcttgaaca tgagtctqct gte:ct.atcta c:ataaatgtc taagttgtat 3100
aaagtccact ttcccttcac gtttt:ttggc tgacctgaaa agaggtaact 3150
tagtttttgg tcacttgttc tcctaaaaat qctatcccta accatatatt 3200
tatatttcgt tttaaaaaca ccc:at:gatgt. ggcacagtaa acaaaccc:tg 3250
ttatgctgta ttattat:gag gaqattcttc att=gttttct ttccttctca 3300
aaggttgaaa aaatgctttt aatttttcac agccgagaaa cagtgcaqca 3350
gtatatgtgc acacagtaag tacacaaatt tgagcaacag taagtgcaca 3400
aattctgtaq tttgctgtat catccaggaa aac:ctgaggg aaaaaaatta 3950
tagcaattaa ctgggcattg tagagtatcc taaatatqtt atcaagtatt 3500
tagagttcta tattttaaag atatatgt~t tcatgtat:tt tctgaaattg 3550
ctttcataga aattttccca ctgatagttg atttttgagg catctaatat 3600
ttacatattt gccttctgaa ctttgtttag acctgtatcc tttatttaca 3650
ttgggttttt ctttcatagt tttggttt~t caca cctqtc cagtct.attt 3700
301

CA 02421364 2003-03-25
attattcaaa taggaaaaat tactttacag gttgttttac tgtagcttat 3750
aatgatactg tagttattcc agtta ctagt ttact.gtcag agggctgcct 3800
ttttcagata aatattgaca taataactga agttattttt ataagaaaat 3850
caagtatata aatctaggaa agg gatcttc tagtttctgt gttgtttaga 3900
ctcaaagaat cacaaatttg tcagtaacat gtagttcxttt agttataz~tt 3950
cagagtgtac agaatggtaa aaattccaat cagtcaaaag aggtcaatqa 4000
attaaaaggc ttgcaacttt ttc:aaaaaaa aaaaaaaaaa 4040
<210> 459
<211> 747
<212> PRT
<213> Homo Sapiens
<400> 459
Met Gly Va1 Trp Leu Asn I,ys Asp Asp Tyr I1e Arg Asp Leu Lys
1 5 10 15
Arg Iie Ile Leu Cys Phe lieu I1e Val Tyr Met Ala Ile Leu Val
20 25 30
Gly Thr Asp Gln Asp Phe '~'yr Ser Leu Leu Gly Val Ser Lys Thr
35 40 45
Ala Ser Ser Arg Glu Ile flrg Gln A7.a Phe Lys Lys Leu Ala Leu
50 55 60
Lys Leu His Pro Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly
65 70 75
Asp Phe Leu Lys lle Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu
80 85 90
Asp Leu Arg Lys Lys Tyr Asp Lys Tyr Gly Glu Lys Gly Leu Glu
95 100 105
Asp Asn Gln Gly Gly Gln 'I'yr Glu Ser Trp Asn Tyr Tyr Arg Tyr
1i0 115 120
Asp Fhe Gly Ile Tyr Asp Asp Asp I?ro Glu Ile I1e Thr Leu Glu
125 130 135
Arg Arg Glu Phe Asp Ala F:la Vai Asn Ser Gly Glu Leu Trp Phe
140 195 150
Val Asn Phe Tyr Ser Pro Gly Cys Ser His C ys His Asp Leu Ala
155 160 165
Pro Thr Trp Arg Asp Phe A.La Lys Glu Val Asp G.ly Leu Leu Arg
170 175 180
Ile Gly Ala Val Asn Cys Gly Asp Ash: Arg Met Leu Cys Arg Met
185 190 195
Lys Gly Val. Asn Ser 'lyr Fro Ser Leu Phe ILe Phe Arg Ser Gly
200 205 210
302

CA 02421364 2003-03-25
Met Ala Pro Val Lys T yr His G.iy Asp Arg Ser l:ys Glu Ser Leu
215 220 225
Val Ser Phe Ala Met Gln His Va;l Arq_ Ser Thr Val Thr Glu Leu
2~;0 2 35 290
Trp Thr Gly Asn Phe Vai Asn Star Ile G~~.n Thr A1a Phe Ala Ala
295 2':0 255
Gly Ile Gly Trp Leu Ile Thr Pt:e Cys Seer Lys Gly G.l.y Asp Cys
260 2f~~> 270
Leu Thr Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Phe Leu
275 280 285
Asn Ser Leu Asp Ala Lys i~lu Ile Tyi: Le:u Glu Val Iie Hi.s Asn
290 295 300
Leu Pro Asp Phe Glu Leu ~eu Ser Ala A:~n Tlnr Leu Glu Asp Arg
305 310 315
Leu Ala His His Arg Trp heu Le~u Phe Phe His Phe Gly Lys Asn
32 0 32 5 330
Glu Asn Ser Asn Asp Fro (~lu Leu Lys Lys Leu Lys Thr Leu Leu
335 340 395
Lys Asn Asp His Ile Gln '~~al Gly Arr7 Phe Asp ('ys Ser Ser Ala
350 3'~_'~ 360
Fro Asp Ile Cys Ser Asn Leu Tyr Val Phe Gln Fro Ser Leu Ala
365 370 375
Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu Ile His His Gly
380 3~5 390
Lys Lys Ile Leu Tyr Asp '_1e Leu Ala Phe Ala Lys Glu Ser Val
395 4C0 905
Asn Ser His Val Tl-:r Thr Leu Gly Pro Gln Asn Fhe Pro Ala Asn
910 41'_. 420
Asp Lys Glu F'r'o Trp Leu Va~ Asp Phe Phe Ala F'ro Trp Cys Pro
925 930 935
Fro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu
490 995 450
Leu Tyr Gly G1n Leu Lys :'he Gly Thr Leu Asp Cys Thr Val His
955 960 465
Glu Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr
970 975 980
Val Val Phe Asn Gin Ser Asn Ile I3is Glu Tyr Glu Gly His His
985 490 995
Ser Aia Glu Gln Ile Leu Glu Phe Iie Glu Asp Leu Met Asn Pro
500 505 510
Ser Val Val Ser Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr
515 520 525
303

CA 02421364 2003-03-25
Gln Arg Lys His Asn Glu Val Twp Met Val Asp Phe Tyr Ser Pro
5,55 54O
Trp Cys His Pro Cys Gln Val Le~u Met Fro Glu Trp Lys Arg Met
545 550 555
Ala Arg Thr Leu Thr Gly Leu Ile Asn V<'il Gly Ser Ile Asp Cys
560 565 570
Gln Gln Tyr His Ser Phe Cys Ana Gln G7u Asn Val Gln Arg Tyr
575 580 585
Pro Glu I1e Arg Phe Phe Pro Pro Lys Ser Asn Lys A1a Tyr Gln
590 595 600
Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu Arg
605 670 615
Ile Trp Gly Leu G'ly Phe Leu Prc ~~ln Val Ser Thr Asp Leu Thr
620 625 630
Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys Asn His Trp
635 690 645
Val ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe
650 655 660
Ala Pro Glu Ph a Glu Leu :i.eu A~a Arg Met Ile Lys Gly Lys Val
665 670 675
Lys Ala Gly Lys Val Asp c:ys Gin Ala Tyr Ala Gln Thr Cys Gln
680 685 690
Lys Ala Gly I1e Arg Ala 'f'yr Pro 'fhr Val Lys Phe Tyr Phe Tyr
695 700 705
Glu Arg Ala Lys Arg Asn fhe Gln G1~n Glu Gi.n Ile Asn Thr Arg
710 715 720
Asp Ala Lys Aia Ile Ala Ala Leu Ile Ser Glu Lys Leu Giu Thr
725 730 735
Leu Arg Asn Gln Gly hys Arg Asn hy; Asp Gl.u Leu
790 745
<210> 460
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 460
actccccagg ctgttcacac tgc:c 29
<210> 961
<211> 24
<212> DNA
<213> Artificial
304

CA 02421364 2003-03-25
<220>
<221> Artificial Sequence
<222> 1.-29
<223> Artificial Sequence
<400> 461
gatcagccag ccaataccag cagc 24
<210> 462
<211> 50
<212> DNF,
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-50
<223> Artificial Sequence
<900> 962
gtggtgatga tagaatgctt tgccgaatga aaggagtcaa cagctatccc 50
<210> 963
<211> 1818
<212> DNA
<213> Homo sapiens
<900> 463
agacagtacc tcctccctag gactacac:aa ggact:gaacc agaaggaaga 50
ggacagagca aagccatgaa catcatccta gaaatccttc tgcttctgat 100
caccatcatc tactcctact: tggagtcc;tt ggtg<3agttt ttcattcctc 150
agaggagaaa atctgtggct ggggagattg ttctcattac tggagctggg 200
catggaatag gcaggcagac tacttatgaa tttgcaaaac gacagagcat 250
attggttctg tgggatatta ataagcgcgg tgtggaggaa actgcagc,tg 300
agtgccgaaa actaggcgtc actgcgcotg cgtatgtggt agactgcagc 350
aacagagaag agatctatcg ctcactaaat caggtqaaga aagaagtggg 400
tgatgtaaca atcgtggtga ataatgctgg gacaqtatat ccaaccgatc 950
ttctcagcac caaggatgaa gacla-tacca agacatttga ggtcaacatc 500
ctaggacatt tttggatcac: aaaagcac:tt cttcc:atcga tgatggagag 550
aaatcatggc cacatcgtca caqtggcttc agtgtqcggc cacgaaggga 600
ttccttacct catcccatat: tgttccagca aatttgccgc tgttggcttt 650
cacagaggtc tgacatcag<c acttc~agccc ttgggaaaaa ctggtatcaa 700
aacctcatgt ctctgcccag ttrttgtc;aa tactgggttc accaaaaatc 750
caagcacaag attatggcct: gtattggaga c~agatgaagt cgtaagaagt B00
ctgatagatg gaatacttac caataagaaa atgatt.tttg ttccatcgta 850
tatcaatatc tttctgagac tacagaagtt tc:ttc:ctgaa cgcgcctcaq 900
30'>

CA 02421364 2003-03-25
cgattttaaa tcgtatgcag aatattc<iat tt gaagcagt ggttggccac 950
aaaatcaaaa tgaaatgaat aastaagc_-tc cagccagaga tgtatgcatg 1000
ataatgatat gaatagtttc gaatcaatgc tgcaaaqctt tatt~tca~~at 1056
tttttcagtc ctgataatat taaaaacattt ggtttgqcac tagcagcagt 1100
caaacgaaca agattaatta ccr_gtcttcc tgtttctcaa gaatatttac 1150
gtagtttttc ataggtctgt ttttcctt_t.c atgcctctta aaaacttctg 1200
tgcttacata aacatactta aaaggtttt.c tttaagatat tttatttttc 1250
catttaaagg tggacaaaag ctacctccct aaaagtaaat acaaagagaa 1300
cttatttaca cagggaagat ttaagactgt tcaagtagca ttccaatcta 1350
tagccatgcc acagaatatc aacaagaaca cagaatcaagt gcac:agctaa 1900
gagatcaagt ttcagcaggc agctttatct caacctggac atattttaag 1450
attcagcatt tgaaagattt cc~~tagcctc ttcct:ttttc attagcccaa 1500
aacggtgcaa ctctattctg gactttatta cttgattctg tcttctgtat 1550
aactctgaag tccaccaaaa gtggacc<.:tc t.atatttcct ccctttttat 1600
agtcttataa gatacattat gaaaggtc.~ac cgactct:att ttaaatctc;a 1650
gaattttaag ttctagcccc atg ataauct ttttctttgt aatttatgct 1700
ttcatatatc cttggtccca gagatgttta gacaatttta ggctcaaaaa 1750
ttaaagctaa cacaggaaaa ggaactgtac tggctattac ataagaaaca 1800
atggacccaa gagaagaa 1818
<210> 964
<211> 300
<212> PRT
<213> Homo Sapiens
<900> 964
Met Asn Ile Ile Leu Glu 1e Leu Leu LEU Leu Ile Thr Ile Ile
1 5 10 15
Tyr Ser Tyr Leu Glu Ser ;~eu Val Lys Phe Phe Ile Pro Gln Arg
20 25 30
Arg Lys Ser Val A7.a Gly ;slu I'_e Va'1 Leu Ile T'hr Gly Ala Gly
35 90 95
His Gly Ile Gly Arg Gln Thr TY:r 'I'yr Glu Pine P.la Lys Arg Gln
50 ~5 60
Ser Ile Leu Val Leu Trp Asp I1e Asn Lys Arq_ Gly Val Glu Glu
65 70 75
Thr Ala Al.a Glu Cys Arg Lys Leu Giy Val Thr Al.a His Ala Tyr
80 85 90
Val Val Asp Cys Ser Asn Arg Glu Glu Ile 'I'yr Arg Ser Leu Asn
306

CA 02421364 2003-03-25
95 1010 7 05
Gln Val Lys Lys Glu Val Gly Asp Val Thr I1e Va1 Val Asn Asn
110 175 120
Ala Gly Thr Val Tyr Pro Ala Asp L~eu Leu Ser Thr Lys Asp Glu
125 1 30 135
Glu Ile Thr Lys Thr Phe Glu Val .Ilsn Ile Leu Gly Hi.s Phe Trp
190 195 150
Ile Thr Lys Ala Leu Leu Prc> Ser Met Met Glu Arg Asn His Gly
155 160 165
His I=le Val Thr Val Ala Ser Val Cys Gly His Glu Gly Ile Pro
170 1~5 180
Tyr Leu Ile Pro Tyr Cys Ser SE~r Lys Phe Ala Ala Val Gly Phe
185 190 195
His Arg Gly Leu Thr Ser i~lu LE:u Gln Ala Leu Gly Lys Thr Gly
200 205 210
Ile Lys Thr Ser CyS heu Cys Pro Val Phe Val. Asn Thr Gly Phe
215 220 225
Thr Lys Asn Pro Ser Thr llrg Leu Trp Pro Val Leu Glu Thr Asp
230 2~~5 290
G1u Val Val Arg Ser Leu 7.1e A~-p Giy Ile Leu Thr Asn Lys Lys
245 250 255
Met Ile Phe Va1 Pro Ser Tyr Ile Asn Ile Phe Leu Arg Leu G1n
260 2E~5 270
Lys Phe Leu Pro Glu Arg Ala Ser Aia Ile Leu Asn Arg Met G1n
275 2~0 285
Asn Ile Gln Phe Glu Ala Val Val Gly His Lys Ile Lys Met Lys
290 295 300
<210> 465
<211> 159
<212> DNA
<213> Homo Sapiens
<900> 965
cggcggcggc. tgcgggcgcg agqtgagqgg cqcgaqgtga ggggcgcgag 50
gttcccagca ggatgccccg gctctgcagg aagctgaagt gagaggc<:cg 100
gagagggccc agcccgcccg ggqc<iggatg a<:caaggccc ggctgttc:cg 150
gctgtggctg gtgctggggt cggt<lttc:at gatcct:gctg atcatcgtgt 200
actgggacag cgcaggcgcc gcgcacttct ac:ttgcacac gtccttctct 25C
aggccgcaca cggggccgcc gctgcccacg cccgggccgg acagggacag 300
ggagctcacg gccgactccg atgtcgacga gtttctggac aagtttctca 350
gtgctggcgt gaagcagagc gaccttccca gaaaggagac ggagcagccg 900
30l

CA 02421364 2003-03-25
cctgcgccgg ggagcatgga qgagagc~tg agag<~ctacg actqgtcccc 950
gcgcgacgcc cggcgcagcc cagaccaqgg ccggcaqcag gcggagcgqa 500
ggagcgtgct gcggggcttc tgcgccaact ccagcctggc cttccccacc 550
aaggagcgcg cattcgacga catccccnac tcggagcaga gcc~jcctgat 600
cgtggacgac cggcacgggg ccatctactg ctacgtc,Iccc aaggtggcct 650
gcaccaactg gaagcgcgtg atgatcgtgc tgagcgqaag cctqctgcac 700
cgcggtgcgc cctaccgcga cccgctg<:gc atcccgcgcg agcacgtgca 750
caacgccagc gcgcacc:tga ccttcaae:aa gttct=gqcgc cgctacggga 800
agctctcccg ccacctcatg aaggtcaugc tcaagaagta cac<:aagttc 850
ctcttcgtgc gcgacccctt cgtgcgcctg atctccgcct tccgcagcaa 900
gttcgagctg gagaacgagg ag~tctaccg ~;aagt:tcgcc gtgc:ccatgc 950
tgcggctgta cgccaaccar_ accagcctgc ccgcctcggc gcgcgaggcc 1000
ttccgcgctg gcctcaaggt gtccttcqcc aacttcatcc agtacctgct 1050
ggacccgcac acggagaagc tggcgccctt caacgaqcac tggc:ggcagg 1100
tgtaccgcct ctgccacccg tgc cagatcg actacgactt cqtggggaag 1150
ctggagactc tggacgagga cgccgcg<:ag ctgct_gcagc tactccaggt 1200
ggaccggcag ctccqcttcc ccccgag<:ta ccggaacagg accgccagca 1250
gctgggagga qgactggttc gcc;aagatcc ccctqqc:ctg gaggcagcaq 1300
ctgtataaac tctacgaggc cgactttqtt c:tcttcggct accccaagcc 1350
cgaaaacctc: ctccgagact gaaagctt tc qcgt.t:gc:ttt ttctcgcgtq 1900
cctggaacct qacgcacgcg cactccacatt tttttatgac ctacgatttt 1950
gcaatctggg cttcttgttc actccactgc ctctatccat tgagtactgt 1500
atcgatattg ttttttaaqa ttaatatatt tcag<ttattt aatacga 1547
<210> 46E
<211> 919
~212> PRT
<213> Homo sapiens
<900> 46E
Met. Thr Lys Ala Arg Leu Phe Arg L~eu Trp Leu Val Leu G1y Ser
1 5 7 0 15
Val Phe Met Ile Leu Leu I1e Ile Val Tyr Trp Asp Ser Ala Gly
20 a.5 30
Ala Ala His Phe Tyr Leu His Thr Ser Phe Ser Arg Pro His Thr
35 40 45
Gly Pro Pro Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu
50 55 60
30f

CA 02421364 2003-03-25
Thr Ala Asp Ser Asp Val lisp Glu Phe Leu Asp Lys Phe Leu Ser
65 ~0 75
Ala Gly Val Lys Gln Ser Asp Leu Fro Arg Lys Glu Thr Glu G1n
80 85 90
Pro Pro Ala Pro Gly Ser Met Glu Glu Ser Val Arq Gly Tyr Asp
95 100 105
Trp Ser Prc Arg Asp Ala Arch Arg Ser Pro Asp Gln Gly Arg Gln
110 115 120
Gln Ala Glu Arg Arg Ser Va.i Leu Arq Gly Phe Cys Aia Asn Ser
125 1~~0 135
Ser Leu Ala Phe Pro Thr lays Glu Arq Ala Phe Asp Asp Ile Pro
140 195 150
Asn Ser Glu Leu Ser His Leu Ile Val A~;p Asp Arg His Gly Ala
155 160 165
Ile Tyr Cys Tyr Val Pro Lys Va.l Ala Cys Thr Asn Trp Lys Arg
170 175 180
Val Met Ile Val Leu Ser (~ly Ser Leu Leu His Arg Gly Ala Pro
185 190 195
Tyr Arg Asp Pro Leu Arg Cle Pro Arg Glu His Val His Asn Ala
200 205 210
Ser Ala His Leu Thr Phe lisp Lys Fhe Trp Arg Arg Tyr Gly Lys
2i5 220 225
Leu Ser Arg His Leu Met lays Val Lys Leu Lys Lys Tyr Thr Lys
230 23.5 240
Phe Leu Phe Val Arg Asp Pro Phe Val Arq Lcu Ile Ser Al.a Phe
245 250 255
Arg Ser Lys Phe Glu Leu Glu Asn G:lu Glu Phe Tyr Arg Lys Phe
260 265 270
Ala Val Pro Met Leu Arg lieu Tyr Ala Ann His Thr Ser Leu Pro
2'75 280 285
Ala Ser Ala Arg Glu Ala F'he Arg Ala Gly Leu Lys Val Ser Phe
290 295 300
Ala Asn Phe Ile Gln Tyr Leu Le-a Asp Pro His Thr Glu Lys Leu
305 310 315
Ala Pro Phe Asn Glu His Trp Arg Gln Val Tyr Arg Leu Cys His
320 325 330
Pro Cys Gln Ile Asp Tyr Asp PY,e Vai Gly Lys Leu Glu Thr Leu
335 390 345
Asp Glu Asp Ala Ala Gln Leu Leu Gln Leu Leu Gln Val Asp Arg
350 355 360
Gln Leu Arg Phe Pro Pro Ser Tyr Arg Asn Arg Thr Ala Ser Ser
365 370 375
309

CA 02421364 2003-03-25
Trp Glu Asp Trp lle Pro Ala Trp Gln
Glu E'he Leu Arg
Ala Lys


380 385 390


Gln Leu Lys Leu Asp Phe Leu Phe Tyr
Tyr 'I'yr Val Gly
c~lu
Aia


395 9C0 405


Pro Lys Glu Asn Asp
Pro Leu :~en
Arg


410


<210>
467


<211>
1071


~212>
DNA


<213> apiens
Homo
S


<400>
467


tcgggccagaattcggcacgaggcggcacgagggcgacggcctcacgggg50


ctttggaggtgaaagaggcccagagtagagagagagagagaccgacgtac100


acgggatggctacgggaacgcgc:tatgccgggaaggtggtggtcgtgacc150


gggggcgggcgcggcatcggagctgggatcgtgcgcgccttcgtgaacag200


cggggcccgagtggttatctgccXacaaggatgagtctgggggccgggccc250


tggagcaggagctccctggagct.gtcttcatcctctgtgatgtgactcag300


gaagatgatgtgaagaccctggtttctgagaccatccgccgatttgg<:cg350


cctggattgtgt'tgtcaacaacgctggccaccacccacccccacagaggc400


ctgaggagacctctgcccagggattccgccagctgctggagctgaaccta450


ctggggacgtacaccttgaccaagctcgccct:cccctacctgcggaagag500


tcaagggaatgtcatcaacatct.ccagc:ctggtgggggcaatcggccagg550


cccaggcagttccctatgtggccaccaagggggcagtaacagccatgacc600


aaagctttggccctggatgaaagtccatatggtgtccgagtcaactgtat650


ctccccaggaaacatctggacccvcgctgtgggaggagctggcagccttaa700


tgccagaccctagggccacaat<:cgagagggc<xtgctggcccagccactg750


ggccgcatgggccagcccgctgaggtcggggctgcggcagtgttcctggc800


ctccgaagccaacttctgcacgggcattgaactgctcgtgacggggggtg850


cagagctggggtacgggtgcaaggccaatcggagcacccccgtggacgcc900


cccgatatcccttcctgatttctctcatttca acttggggcccccttc:ct950


aggactctcccaccccaaactccaacctgtatcagatgcagcccccaagc1000


ccttagactctaagcccagt-tagcaaggtgccgggtcaccctgcaggttc1050


ccataaaaacgatttgcagcc X071


<210>
468


<211>
270


<212>
PRT


310

CA 02421364 2003-03-25
<213> Homo Sapiens
<900>468


Met A1aThrG1yThrArg'"yrAlaGly LysValValValValThr


1 5 1C 15


Gly GlyGlyArgGlyIleGlyA1aGly IleValArgAl.aPheVal


20 c5 30


Asn SerGlyA1aArgValValIleCys AspLysAspGluSerGly


35 90 95


Gly ArgAl.aLeuGluGlnGluLeuPro GlyAlaValPheIleLeu


50 5' 60


Cys AspValThrGlnGluAspAsp'JalLysThrLeuValSerGl.u


65 70 75


Thr IleArgArgPheGlyF~rgLeuAsp CysValValAsnAsnAla


80 85 90


Gly HisHisProProProGlnArgPro GluGluThrSerAlaGln


95 100 105


Gly PheArgGlnLeuLeu!sluLe:uAsn LeuLeuGlyThrTyrThr


110 115 120


Leu ThrLysLeuAlaLeuPro'IyrLeu ArgLysSerGlnGlyAsn


125 130 135


Val IleAsnIleSerSerheuValGly AlaIleGlyGinAlaGln


140 195 150


Ala ValProTyrValAlaThrLysGly AlaValThrAlaMetThr


155 160 165


Lys AlaLeuAlaLeuAsp~'~luSerPro TyrGlyValArgValAsn


1'70 1 180
i5


Cys IleSerProGlyAsnIleTrpThr ProLeuTrpG1uGluLeu


185 190 195


Ala AlaLeuMetProAspProArgAla ThrIleArgGluGlyMet


200 2_05 210


Leu AlaGlnProLeuGlyArgMEtGly GlnProAlaGluValGly


215 220 225


Ala AlaA1aValPheheuAlaSerG.luAlaAsnPheCysThrGly


230 2 240
j5


Ile GluLeuLeuVal.Thrc~l.yGlyAla GluLeuGlyTyrGlyCys


295 250 255


Lys AlaSerArgSerThrProValAsp AlaProAspIleFroSer


260 265 270


<210>
969


<211>
687


<212>
DNA


<213> o ns
Hom sapie


<900>
969


31..

CA 02421364 2003-03-25
aggcgggcag cagctgcagg ctgacctt:gc agcttgqcgg aatggactgg 50
cc:tcacaacc tgctgtttct tcttaccatt tccat_cttcc tggggctggg 100
ccagcccagg agccccaaaa gcaagaggaa ggggcaaggg cggcctgggc 150
ccctggcccc tggccctcac caggtgc~,ac tgga<_~ctggt gtcacggatg 200
aaaccgtatg cccgcatgga ggagtat<xag aggaacatcg aggagatggt 250
ggcccagctg aggaacagct cagagctcrgc c.cagagaaag tgtgaggtca 300
acttgcagct gtggatgtcc aac:aagactga gcctgtctcc ctggggctac 350
agcatcaacc acgaccccag ccqtatcccc gtggacctgc cggaggcacg 900
gtgcctgtgt ctgggctgtg tgaacccctt caccatgcag gaggaccgca 950
gcatggtgag cgtgccggtg ttcagccagg t.tcctgtgcg ccgccgcctc 500
tgcccgccac cgccccgcac agggcctt.gc cgccagcgcg cagtcatgga 550
gaccatcgct gtgggctgca cctgcatctt ctgaatcacc tggcccagaa 600
gccaggccag cagcccgaga ccatcctc~ct tgcacctttg tgccaagaaa 650
ggcctatgaa aagtaaacac tgacttttga aagcaag 68'7
<210> 970
<211> 180
<212> PRT
<213> Homo sapiens
<900> 970
Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile
1 5 10 15
Phe Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys .'~er Lys Arg Lys
20 25 30
Gly Gln Gly Arg Pro Gly Pro LF~u Ala Pro Gly Pro His Gln Val
35 90 95
Pro Leu Asp Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu
50 ';5 60
Glu Tyr G1u Arg Asn Ile Glu Giu Met Val A1a Gln Leu Arg Asn
65 70 75
Ser Ser Glu Leu Ala Gln Arg Ls;~s Cys Glu Val Asn Leu Gln Leu
80 ~ 85 90
Trp Met Ser Asn Lys Arg Ser Leu Ser Po Trp Gly Tyr Ser Ile
95 100 105
Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro G1u Ala Arg
7 10 1-15 120
Cys Leu Cys Leu Gly Cys Val Asn Fro Phe Thr Met Gln Glu Asp
125 1:30 135
Arg Ser Met Val Ser Val E'ro V<~l Phe Ser Gln Val Pro Val Arg
190 145 150
31:'

CA 02421364 2003-03-25
Arg Arg Leu Cys Pro Pro ,'re Pro Arg Thr Gly Pro Cys Arg Gln
155 160 165
Arg Ala Val Met Glu Thr Ile Ana Val Gly Cys Thr Cys Ile Phe
170 1?5 180
<210> 471
<211> 2368
<212> DNA
<213> Homo Sapiens
<400> 471
gcgccgccag gcgtaggcgg ggtggccott gcgtctcccg cttccttgaa 50
aaacccggcg ggcgagcgag gctgcggcc:c ggccc;ctgc:c cttc:cccaca 100
ctccccgccg agaagcctcg ctcggcgc.cc aacatggcgg gtgggcgctg 150
cggcccgcag ctaacggcgc tcctggcc:gc ctgg<itcgcg gctgtggcgg 200
cgacggcagg ccccgaggag gcc:gcgct gc cgccggagca gagc:cgggtc 250
cagcccatga ccgcctccaa ctggacgc:tg gtgatggagg gcgagtggat 300
gctgaaattt tacgccccat~ ggtgtcca.tc <:tgccagcag actgattcag 350
aatgggaggc ttttgcaaag aatggtga:aa tacttcagat cagtgtgggg 400
aaggtagatg tcattcaaga accaggtttg adtggccgct tctttgtcac 950
cactctccca gcattttttc atgcaaac~ga tggg<~tattc c:gccgttatc 500
gtggcccagg aatcttcgaa gacctgcaga attatatctt agagaagaaa 550
tggcaatcag tcgagcctct gactggctgg aaatccccag cttctctaac 600
gatgtctgga atggctggtc tttttagcat ctctggcaag atat.ggcatc 650
ttcacaacta tttcacagtg actcttgoaa t:tcctgcttg gtgttcttat 700
gtgtttttcg tcatagccac cttggttttt ggccttttta tgggtctgqt 750
cttggtggta at-atc:agaat gtttctat gt gccac:tt:cca aggcatttat 800
ctgagcgttc tgagcagaat cggagatcag aggactgctca tagagctgaa 850
cagttgcagg atgcggagga ggaaaaaaat gattc:aaatg aagaagaaaa 900
caaagacagc cttgtagatg atgaagaaga gaaagaagat cttggcgatg 950
aggatgaagc agaggaagaa gaggaggagg ~acaacat.ggc tgctggtgtg 1000
gatgaggaga gaagtgaggc caatgatcag gggcccccag gagaggacgg 1050
tgtgacccgg gaggaagtag aga:ctgac;ca ggctgaagaa ggcatotctg 1100
agcaaccctg cccagctgac acagaggtgg tggaagactc cttgaggc:ag 1150
cgtaaaagtc agcatgctga caagggactg tagatttaat gatgcgtttt 1200
caagaataca caccaaaaca atatgtc~gc t=tccc:tttgg cctgcagttt 1250
313

CA 02421364 2003-03-25
gtaccaaatc cttaattttt cctgaatqag caagc;ttctc ttaaaagatg 1300
ctctctagtc atttggtctc atggcagtaa gcctc:atgta tactaaggag 1350
agtcttccag gtgtgacaat caggatatag aaaaacaaac gtagtgttgc 1400
gatctgtttg gagactggga tgggaacaag ttcatttact taggggtcag 1450
agagtctcga ccagaggagq ccaittcccag tcctaatcag caccttccag 1500
agacaaggct gcaggccctg tgaaatgaoa qccaagcagg agccttggct 1550
cctgagcatc cccaaagtgt aacgtagaag ccttqcatcc ttttcttgtg 1600
taaagtattt atttttgtca aattgcac~ga aacatcaggc accacagtgc 1650
atgaaaaatc tttcacagct agaaattaaa agggccttgg gtatagagag 1700
cagctcagaa gtcatcccag ccctctgaat ctcctgtgct atgttttatt 1750
tcttaccttt aatttttcca gcatttccac catgggcatt caggctctcc 1800
acactcttca ctattatct:: ttg gtcagag gactc:caata acagccaggt 1850
ttacatgaac tgtgtttgtt cat:tctg~cc taagc~ggttt agataatcaq 1900
taaccataac ccctgaagct gtgactgcca aacatctcaa atgaaatgtt 1950
gtggccatca gagactcaaa aggaagtaag gattttacaa gacagattaa 2000
aaaaaaattg ttttgtccaa aat:atagttg ttgttgattt ttttttaagt 2050
tttctaagca atatttttca agcvc<~ga«gt cctctaagtc ttgccagtac 2100
aaggtagtct tgtgaagaaa agtt<Iaatac tgttttgttt tcatctcaag 2150
gggttccctg ggtcttgaac tactttaata ataacaaaaa aaccacttct 2200
gattttcctt cagtgatgtq cttttg_qtga aagaattaat gaactccagt 2250
acctgaaagt gaaagatttg attttgtttc catcttctgt aatcttccaa 2300
agaattatat ctttgtaaat ctcvtcaatac tcaatctact gtaagtaccc 2350
agggaggcta atttcttt 2368
<210> 972
<211> 349
<212> PRT
<213> Homo sapiens
<400> 972
Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala Leu Leu Ala
Ala Trp Ile Ala Ala Vai Ala Ala Thr Ala Gly Pro Glu Glu Ala
20 25 30
Ala Leu Pro Pro Glu Gln ,e= Arq_ Va1 Gln Pro Met Thr Ala Ser
35 90 45
Asn Trp Thr Leu Val Met Glu G7y Glu Trp Met Leu Lys Phe Tyr
50 55 60
31L

CA 02421364 2003-03-25
Ala Pro Trp Cys Pro Ser (:ys Gln Gln Thr Asp Ser Glu Trp Glu
65 i'0 75
Ala Phe Ala Lys Asn Gly Glu Ile Leu Gln Ile Ser Va1 Gly Lys
80 E'5 90
Val Asp Val Il.e Gin Glu 'r'ro Giy Leu Se-r Gly Arg Phe Fhe Val
95 lCiO 105
Thr Thr Leu Pro Ala Phe I'he Hps Ala Lys Asp G1y Iie Phe Arg
110 1l 5 120
Arg Tyr Arg Gly Pro Gly Ile Phe Glu Asp Leu Gln Asn Tyr Ile
125 1 30 135
Leu Glu Lys Lys Trp Gln Ser Val. G.lu Pro Leu Thr Gly Trp Lys
140 195 150
Ser Pro Ala Ser Leu Thr Met Ser Gly Met Ala Gly Leu Phe Ser
155 160 165
Ile Ser Gly Lys Iie Trp His Leu His Asn Tyr Fhe Thr Val Thr
1'70 175 180
Leu Gly Iie Pro Ala Trp C;y.s Ser Tyr Val Phe Phe Val Ile Ala
185 190 195
Thr Leu Val Phe Gly Leu Phe ME-'t Gly Leu Val Leu Val Val Ile
200 205 210
Ser Glu Cys Phe Tyr Val Pro Leu Pro Arg His Leu Ser Glu Arg
215 2~:0 225
Ser Glu Gln Asn Arg Flrg Ser Giu Glu Ala His Arg Ala Glu Gln
230 23 _'. 290
Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn G1u Glu Glu
245 250 255
Asn Lys Asp Ser Leu Val lisp Asp Glu Glu Glu Lys Glu Asp Leu
260 265 2 70
Gly Asp Glu Asp Glu Ala Glu Glu G:iu Glu Glu Glu Asp Asn Leu
2'75 280 285
Ala A.La G1y Val Asp C~lu Glu Arg Ser Glu Ala Asn Asp Gln G1y
290 295 300
Pro Pro Gly G1u Asp Gly Val Tt,r Arg Glu Glu Val Glu Pro Glu
305 31 0 315
Glu Ala Glu Glu Gly I1e :3er Glu Gln Pro Cys Pro Ala Asp Thr
320 3a:5 330
Glu Val Val Glu Asp Ser Leu Arg Gln Arg Lys Ser Gl.n His Ala
335 3~0 395
Asp Lys Gly Leu
<210> 973
<211> 24
31 '?

CA 02421364 2003-03-25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<:223> Artificial Sequence
<900> 973
gtccagccca tgaccgcctc caac 24
<210> 479
<211> 29
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 474
ctctcctcat ccacaccagc agcc 29
<210> 475
<211> 44
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-49
<:223> Artificial Sequence
<900> 475
gtggatgctg aaattttacg ccccatggtg tccatcctgc cage 99
<210> 476
<211> 2978
<212> DNA
<273> Homo Sapiens
<900> 476
atctggttga actacttaag ctt:aatttgt taaactccgg taagtaccta 50
gcccacatga tttgactcag agatt:ctctt rtgtccacag acagtcatct 100
caggggcaga aagaaaagag ct:ccaaatg ctatatctat tcaggggc:tc 150
tcaagaacaa tggaatatca tc<:tgattta gaaaatttgg atgaagatgg 200
atatactcaa ttacacttcg actci=caaag caataccagg atagctgttg 250
tttcagagaa aggatcgtgt get:gcatctc ctccttggcg cctcattgct 300
gtaattttgg gaatcctatg ctt:ggtaata ctggtgatag ctgtggtcct 350
gggtaccatg ggggttcttt ccagcccttg tcctcctaat tggattatat 900
atgagaagaa ctgtt:atcta ttc:adcatgt cactaaattc ctgggatgga 950
agtaaaagac aatgctggca actgggctct aatctcctaa agatagac:ag 500
31 E.

CA 02421364 2003-03-25
ctcaaatgaa ttgggattt<i tagtaaaaca agtgt.cttcc caacctgata 550
attcattttg gataggcctt tct:cggcc:cc agactgaggt accatggctc 600
tgggaggatg gatcaacatt ctcvttctaac ttatttcaga tcacraaccac 650
agctacccaa gaaaacccat ctcca aattg tgtatggatt cacgtgtcag 700
tcatttatga ccaactgtgt agtgtgcc:ct catatagtat ttgtgagaag 750
aagttttcaa tgtaagagqa agggtggaga aggagaqaga aatatgtgaq 800
gtagtaagga ggacagaaaa cagaacagaa aagagtaaca gctgaggtca 850
agataaatgc agaaaatgtt:- tagagagctt ggccaactgt aat<:ttaacc 900
aagaaattga agggaqaggc: tgt:gatttct gtatttqtcg acctacaggt 950
aggctagtat tatttttcta gttagtarat cc ctagacat ggaatcaggg 1000
cagccaagct tgagttttta ttttttattt atttattttt ttgagatagg 1050
gtctcacttt gttacccagg ctqgagtcrca gtgg<:acaat ctcgactcac 1100
tgcagctatc tctcgcctca gcccctcaag tagct:gggac tacaggtgca 1150
tgccaccatg ccaggctaat ttttggtatt ttttqtagag actgggtttt 1200
gccatgttga ccaagctggt ct~~taactcc tgggcttaag tgatctgccc 1250
gccttggcct cccaaagtgc tgqgattaca gatgtgagcc accacacctg 1300
gccccaagct tgaattttca ttctgccatt qactt:ggcat ttaccttggg 1350
taagccataa gcgaat<:tta at'tctg<~ct ctatcagagt tgtttcatgc 1400
tcaacaatgc cattgaagtg ca~~ggtgtgt tgcca cgatt tgaccctcaa 1950
cttctagcag tatatcagtt atqaact<aag qgtg<~aatat atttctgaat 1500
agctaaatga agaaatggga aaaaatcttc accacaatca gagcaatttt 1550
attattttca tcagtatgar_ cataattatg attar-catct tagtaaaaag 1600
caggaactcc tactttttct ttatcaatt:a aata<xctcag agagtacatc 1650
tgccatatct ctaatagaat cttttttttt ttttl-ttttt ttt<~agacag 1700
agtttcgctc ttgttgccca ggctqgaqtg caacggcacg atctcggctc 1750
accgcaacct ccgccccctg ggttcaac3ca attctcctgc ctcagcctcc 1800
caagtagc:tg qgattacagt caggcaccac cacacccggc t:aattttqta 1850
tttttttagt agagacaggg ttt.ctccatg tcggtcaggg tagtcc:cgaa 1900
ctcctgacct caagtgatct gcctgcctcg gcctc~ccaag tgctgggatt 1950
acaggcgtga gccactgcac ccagcctaga atcttgtata atatgtaatt 2000
gtagggaaac tgctctcata ggaaagtttt: ctgcttttta aatacaaaaa 2050
tacataaaaa tacataaaat ctgatgarga atata aaaaa gtaaccaacc 2100
3i7

CA 02421364 2003-03-25
tcattggaac aagtattaac attttggaat atgttttatt agttttgtga 2150
tgtactgttt tacaattttt acc:atttttt tcagtaatta ctgtaaaatg 2200
gtattattgg aatgaaacta tatttcctca tgtgca gatt tgtcttattt 2250
tt.ttc:atact: ttcccactgg tgc~tattt tt atttc:caatg gatatttctg 2300
tattactagg gaggcattta cagtcctcto atgttgatta atat.gtgaao 2350
agaaattgta ccaattttac t:aaattatgc agtttaaaat ggatgatttt 2400
atgttatgtg gatttcattt caataaaaaa aaactcttat caaaaaa~:aaa 2950
aaaaaaaaaa aaaaaaaaaa aaaaaaa~24?8
<210> 97?
<211> 201
<212> PRT
<213> Homo Sapiens
<400> 477
Met Glu Tyr His Pro Asp Leu G1u Asn Leu Asp Glu Asp Gly Tyr
1 5 10 15
Thr Gln Leu His Phe Asp Ser. G:n Ser A:n Thr Arg Ile Ala Val
20 a?5 30
Val Ser Glu Lys Gly Ser ~~ys Ala Ala Ser Pro Pro Trp Arg Leu
35 ~10 45
Ile Ala Val Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile
50 _'; ~ 60
Ala Val Va.l. Leu Gly Thr Met G';y Va.1 Leu Ser Ser Pro C:ys Pro
65 ~70 75
Pro Asn Trp Ile Il.e Tyr t;lu L=Y~s Ser Cvs Tyr Leu Phe Ser Met
80 85 90
Ser Leu Asn Ser Trp Asp Gly Sc.r Lys Arg Gln C:ys Trp Gln Leu
95 100 105
Gl.y Ser Asn Leu Leu Lys Ile A,p Se.r SEer Asn C~lu Leu C;l.y Phe
110 l L5 120
Ile Val Lys Gln Val Ser Ser Gn Pro Asp Asn Ser Phe Trp Ile
125 130 135
Gly Leu Ser Arg Pro Gln 'I'hr G.u Val Pro Trp Leu Trp Glu Asp
190 145 150
Gly Ser Thr Phe Ser Ser .4sn Le-'u Phe G.i.n Ile Arg Thr Thr Ala
155 160 165
Thr Gln Gl.u Asn Pro Ser Pro Asn Cys Val Trp Ile His Val Ser
170 175 180
Val Ile Tyr Asp Gln Leu C'ys Ser Val P_.ro Ser Tyr Ser Ile Cys
185 190 195
Glu Lys Lys Phe Ser Met
313

CA 02421364 2003-03-25
200
<210> 478
<211> 27
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-27
<223> Artificial Sequence.
<900> 478
gtccacagac agtcatctca ggagcag 27
<210> 479
<211> 20
<212> DNA
<213> Artificial
<:220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<900> 479
acaagtgtct tcccaacctq 20
<210> 480
<211> 29
<212> DNA
~~213> Artificial
<220>
<:221> Artificial Sequence
<:222> 1-24
<223> Artificial Sequence
<4C0> 980
atcctcccag agccatggta cct:c 2.9
<210> 981
<211> 51
<212> DNA
<213> Artificial
<220>
~:221> Artificial Sequence
<222> 1-51
<223> Artificial Sequence
<400> 981
ccaaggatag ctgttgtttc agagaaaatga tcgtgtgctg catctcctcc 50
t 51
<210> 982
<211> 3819
<212> DNA
<213> Homo Sapiens
<400> 982
ggaaggggag gagcaggcca cacaggcaca ggccggtgag ggacctgccc 50
319

CA 02421364 2003-03-25
agacctggag ggtctcgctc tgtcacac:ag gctgc~agtgc agtggtgtga 100
tcttggctca tcgtaacctc cacctccc:gg rattcaa~xtga ttctcatgcc 150
tcagcctccc gagtagctgg gattacacgt ggtg<3cttcc aagagtgact 200
ccgtcggagg aaaatgactc cc::agtcgct. gctgcagacg acactgttcc 25C
tgctgagtct gctcttcctg gtccaagc;t:g cccacggcag gggc:cacagg 30C
gaagactttc gcttctgcag cc.agcggaac cagacacaca ggagcag.cct 350
ccactacaaa cccacaccag acctgcg<:at. ctcc<jtcgag aactccgaag 400
aggccctcac agtccatgcc cctttccca:g c::agcccaccc tgcttcccga 450
tccttccctg accccagggg cctctacc:ac ttctgc~~tct actggaaccg 500
acatgctggg agattacatc tt:ctctatgg caagcgtgac t:tcttgctga 550
gtgacaaagc ctctagcctc ctctgcttcc agcaccagga ggagagcct.g 600
gctcagggcc ccccgctgtt agccacttct gtcac ctcct ggtggag::cc 650
tcagaacatc agcctgccca gtgccgccag cttcaccttc t:.ccttccaca 100
gtcctcccca cacggccgct cacaatgc:ct cggtggacat gtgcgagctc 750
aaaagggacc tccagctgct cagccagttc c,tga<3ge:atc c:ccagaaggc 800
ctcaaggagg ccctcggctd cc~~ccgcc,ag ccagcagttg cagagcctgg 850
agtcgaaact gacctctgtg agattcatgg gggacatggt gtccttcgag 900
gaggaccgga tcaacgccac ggt.gtggaag ctcc<~gccca c:agccggcct 950
ccaggacc:tg cacatccact cccggcagga ggaggagcag agcgagatca 1000
tggagtactc ggtgctgctg cctcgaa<:ac tcttccagag gacgaaaggc 1050
cggagcgggg aggctgagaa gag actcat:c ctggtggact tcagcagcca 1100
agccctgttc caggacaaga att.ccagc:ca agtcctgggt gagaaggtct 1150
tggggattgt ggtacagaac accaaagt.ag c:caacct:cac ggagcccgt:g 1200
gtgctcactt tccagcacca gct.acagc:cg aaga<itgtga ctctgcaatg 1250
tgtgttctgg gttgaagacc ccacattc~ag cagcccgggg cattggagc.a 1300
gtgctgggtg tgagaccgtc aggagag<taa cccaaac:atc c:tgcttctgc 1350
aaccacttga cctactttgc agtgctgatg gtct<~ctcgg tggaggtgga 1400
cgccgtgcac aagcactacc tgagcct~:ct ctcctacgtg ggctgtgtcg 1450
tctct.gccct ggcctgcctt gtcaccattg ccgcctacct ca gctccagg 1500
gtgcccctgc cgtgcaggag gaaacctcgg gactacacca tcaaggtgca 1550
catgaacctg ctgctggccg tcttcctcXct ggaca cgagc t:tcctgctca 1600
320

CA 02421364 2003-03-25
gcgagccggt ggccctgaca ggctctgagg ctggctgccg agccagtgcc 1650
atcttcctgc acttctccct gct.cacctgc ct:ttcctgga tgggcctc:ga 1700
ggggtacaac. ctctaccgac tcgtggtgga ggtctttgc7c acct:atgtcc 1750
ctggctacct actcaagctg agc;gc:catgg <~caggggct.t. ccccatcttt 1800
ctggtgacgc tggtggccct ggt:ggatgtg gacaactat.g gccccatcat 1850
cttggctgtg cataggactc cactagggcgt catctaccct tccatgtgct 1900
ggatccggga ctccctggtc agctacatca cc:aacctgqg cctcttcagc 1950
ctggtgtttc tgttcaacat ggc:catgca a gccaccatgg tggtgcagat 2000
cctgcggctg cgcccccaca ccc:aaaagtg gt:cacatgtg ctgacact:gc 2050
tgggcctcag cctggtcctt: ggcctgccct gggccttgat cttcttct:cc 2100
tttgcttctg gcaccttcca gct.tc~tcctc ct:ctac<:ttt. tcagcatc:at 2150
cacctccttc caaggcttcc tcatctt<at c:tggtactgg tccatgccagc 2200
tgcaggcccg gggtggcccc tcc:cctctga agagcaactc agacagcgcc 2250
aggctcccca tcagctcggg cagcacctcg tccaqcc:gca tctaggcc:tc 2300
cagcccacct gcccatgtga tgaagcagag atgcggcctc gtcgcacact 2350
gcctgtggcc cccgagccag gce:cagcccc aggccagtca gccgcagact 2900
ttggaaagcc caacgaccat ggagagatgg gccgttgcc:a tggtggacgg 2950
actcccgggc tgggcttttg aat:tggcctt ggggactact cggcactc:ac 2500
tcagctccca cgggactcag aagtgcgccg ccatqctgcc tagggtactg 2550
tccccacatc tgtcccaacc cagc~ggagg cc.tggtctct ccttacaac c 2600
cctgggccca gccctcattg ctc:~ggggcca c,~gccttggat; cttgagggtc 2650
tggcacatcc ttaatcctgt gcc:cctgcct gggac:agaaa tgtggctcca 2700
gtt.gctctgt ctctcgtggt: cac:cctg~~gg gcact.ctgca tcctctgtca 2750
ttttaacctc aggtggcacc cagggcgaat ggggc:ccagg gcagaccttc 2800
agggccagag ccctggcgga ggagagg<cc t:t_tgc:c:agga gcac:agcagc 2850
agctcgccta cctctgagcc caggcccc:ct c:cctccc:tca gccccccagt 2900
cctccctcca tcttccctgg ggttctcctc ctctcccagg qcctccttgc 2950
tccttcgttc acagctgggg gtccccgatt ccaat:gctgt. tttttgggga 3000
gtggtttcca ggagctgcct ggtgtctcct gtaaatgttt gtctactgca 3050
caagcctcgg cctgcccctg agccagg<:tc ggtaccgatg cgtgggctgg 3100
gctaggtccc tctgtccatc tgggcctttg tatgagctgc attgcccttg 3150
ctcaccctga ccaagcacac gcu.tcagagg gg ccctcagc ctctcctgaa 3200
321

CA 02421364 2003-03-25
gccctcttgt ggcaagaact gtggaccatg ccagtcccgt ctggtttcca 3250
tcccaccact ccaaggactg ag<:~ctga<ct c ctctggtga cactggccta 3300
gagcctgaca ctctcctaag aggttctctc caagccccca aatagctcca 3350
ggcgccctcg gccgcccatc atclgttaatt ct~gtc:caaca aacacacaca 3900
ggtagattgc tggcctgttg taggtggtag ggacacagat gaccgacctg 3950
gtcactcctc ctgccaacat tcagtctcxgt at_gtqaggcg t.gcgtgaagc 3500
aagaactcct ggagca acag gga c,3ggc;ag ccatc:attcc tgcctgggaa 3550
tcctggaaga cttcctgcag gagtcagcgt tcaatcttga ccttgaagat 3600
gggaaggatg ttctttttac gta ccaattc tt_ttcrtcttt tgatattaaa 3650
aagaagtaca tgttcattgt agagaatttg gaaacagtag aagagaatca 3700
agaagaaaaa taaaaatcag ctgttgtaat c;gcctagcaa aaaaaaaaaa 3750
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3800
aaaaaaaaaa aaaaaaaaa 381'
<210> 483
<211> 693
<212> PRT
<213> Homo sapiens
<900> 483
Met Thr Pro Gln Ser Leu Leu Gin Thr Thr Leu Phe Leu Leu Ser
1 5 70 15
Leu Leu Phe Leu Va.1 Gln (~ly Ala His G7.y Arg Gly His Arg Glu
20 a5 30
Asp Phe Arg Phe Cys Ser C~ln Axg Asn G7.n Thr His Arg Ser Ser
35 40 45
Leu His Tyr Lys Fro Thr Pro A__p Leu Arg Ile Ser Ile Glu Asn
'.~0 '_;5 60
Ser Glu Glu Ala Leu Thr 'Jal His A1a Pro Phe Pro Ala Ala His
65 ~'0 75
Pro Ala Ser Arg Ser Phe Pro A.:p Pro Aig Gly Leu Tyr His Phe
80 85 90
Cys Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr
95 100 205
Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu
110 1_5 120
Cys Phe Gln His Gln Glu Glu S<:r L.~eu A_ a Gln C-~ly Pro Pro Leu
125 130 135
Leu Ala Thr Ser Val Thr Ser Trp Trp Ser Pro Gln Asn Iie Ser
190 195 1.50
322

CA 02421364 2003-03-25
Leu Pro Ser Ala Ala Ser F'he Thr Phe Ser Phe His Ser Pro Pro
155 160 165
His Thr Ala A:La His Asn Ala Ser Val Asp Met Cys Glu Leu Lys
1?0 175 180
Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His Pro Gln Lys
1S5 190 195
Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln Leu Gln
200 205 210
Ser Leu Glu Ser Lys Leu Thr Ser Va.L Arg Phe Met Gly Asp Met
215 220 225
Val Ser Phe Glu Giu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu
230 ' 235 240
Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln
245 250 255
Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Vai Leu Leu Pro
260 265 270
Arg Thr Leu Phe Gln Arg "'hr Lys Gly Arg Ser Gly Gl.u Ala Glu
2.75 280 285
Lys Arg Leu Leu Leu Val Asp Phe Ser Ser G1n Ala Leu Phe Gln
290 295 300
Asp Lys Asn Ser Ser Gln Val Leu G1y Glu Lys Val Leu Gly Ile
305 310 315
Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val
320 325 330
Leu Thr Phe Gln His Gln Leu Gin Pro Lys Asn Val Thr Leu Gln
3'3.'390 345
Cys Val. Phe Trp Val Glu Asp Pxo Thr Leu Ser Ser Pro Gly His
350 355 360
Trp Ser Ser Ala Gly C:ys Glu TY,r Vai Arg Arg Glu Thr Gln Thr
365 370 375
Ser Cys Phe Cys Asn His heu TL,r Tyr Phe Ala Val Leu Met Val
380 385 390
Ser Ser Val G1u Val Asp Ala Val His Lys His Tyr Leu Ser Leu
395 900 405
Leu Ser Tyr Val Gly Cys Val Val Ser A7a Leu Ala Cys Leu Val
910 975 420
Thr Ile Ala Ala Tyr Leu c~ys Ser Arg Val Pro Leu Pro Cys Arg
925 930 435
Arg Lys Fro Arg Asp Tyr 'I'hr Ile Lys V<~l His Met Asn Leu Leu
490 995 950
Leu Ala Vai Phe Leu Leu Asp TY:r Ser Phe Leu Leu Ser Glu Pro
455 460 965
323

CA 02421364 2003-03-25
Val A1a Leu '1'hr G1y :>er (~lu Ala.~ Gly Cys Arg Ala Ser Ala Ile
970 975 980
Phe Leu His Pk:e Ser Leu Leu Thr Cys Leu Ser T:rp Met Gly Leu
985 990 995
Glu Gly 'I'yr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr
500 505 510
Tyr Val Pro Gly Tyr Leu heu Lys Leu Ser Ala Met. Gly Trp Gly
515 520 525
Phe Pro Ile Phe heu Val '.Fhr Leu Val Ala Leu Val Asp Val Asp
530 535 590
Asn Tyr Gly Pro Ile Ile L,eu Ala Va:L His Arg Thr Pro Glu Gl.y
545 550 555
Val Iie Tyr Pro Ser Met c:."ys Trp Ile Arg Asp Ser Leu Val Ser
560 565 570
Tyr Ile 'Ihr Asn Leu Gly heu Phe Ser Leu Val Phe Leu Phe Asn
57 '. 580 585
Met Ala Met Leu Ala Thr Met Val Val. Gln Ile Leu Arg Leu Arg
590 595 600
Pro His Thr G:Ln Lys Trp her His Val Leu Thr Leu Leu G1y Leu
605 610 615
Ser Leu Val Leu Gly Leu Prc- Trp Ala Leu Ile Phe Phe Ser Phe
62 0 625 630
Ala Ser Gly Thr Phe Gin l.~eu Val Va.1 Leu Tyr Leu Phe Ser Ile
635 690 695
Ile "'hr Ser Phe Gl.n Gly Phe Len Ile Phe Ile Trp Tyr Trp Ser
650 655 660
Met Arg Leu Gln Ala Arq C~ly Gly Pro Ser Pro Leu Lys Ser Asn
665 670 675
Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser
680 685 690
Ser Arg Ile
<210> 989
<:211> 516
<212> DNA
<213> Homo sapiens
<220>
<221> unsure
<222> 68, 70, 89, 197
<223> unknown base
<400> 989
tgcctggcct gccttgtcaa ca<3tgcccact t.act<a gctt ccaggttgcc 50
ctgccttgca gaggaaancn tcgggactac accnt=caagt gcacatgaac 100
329

CA 02421364 2003-03-25
ctgctgctgg ccgtcttcct: gctggacacg agctt:cc:tgc tcagcgnagc 150
cggtggccct gacaggctct: gaagg ctggc t.gccc~agcca gtgccatctt 200
cctgcacttc tcctgctcac ctgcctttcc t.ggatgggcc tcgaggggta 250
caacctctac cgactcgtgg tggaggtott t.ggcacctat gtcc:ctggct 300
acctactcaa gctgagcgcc atgggctggg gcttc:cccat cattctggtg 350
acgctggtgg ccctggtgga tgtggacaac tatggcccca tcat.cttggc 400
tgtgcatagg actccagagg gcgtcatc:ta cccttccatg tgctggatcc 450
gggactccct ggtcagctac att:accaacc tgggc:ctctt cagcctggtg 500
tttctgttca acatgg 516
<210> 485
<211> 22
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-22
~:223> Artificial Sequence
<900> 985
ggcattggag cagtgctggg tg 22
<:210> 486
<21i> 24
<212> DNA
<:213> Artificial
<220>
<2:21> Artificial Sequence
<:222> 1-24
<:22 j> Artificial Sequence
<900> 486
t.ggaggccta gatgc.ggctg gacg 24
<210> 487
<211> 2849
<212> DNA
<21i> Homo sapiens
<220>
<221> unsure
<:222> 2715
<223> unkncwn base
<900> 987
cggacgcgtg ggcggacgcg tgggcggacg cgtgggcgga cgcgtgggct 50
ggttcaggtc caggttttgc tttgatc< tt ttca<3aaact. ggac~acacag 100
aagagggctc taggaaaaag ttttggatgg gattatgtgg aaactaccct 150
gcgattctct gctgccagag cag gctcggc gct.tccaccc c:agtgcagcc 200
325

CA 02421364 2003-03-25
ttcccctggc ggtggtgaaa gagactcggg agtcactgct tccaaagt~gc 250
ccgccgtgag tgagctctca ccc:c<3gtcag ccaaatgagc ctcttcgggc 300
ttctcctgct gacatctgcc ctggc~cgCCC agagacaggg gactcaggcg 350
gaatccaacc tgagtagtaa attccagttt tccaacaaca aggaacagaa 400
cggagtacaa gatcctcagc; atgagagaat tattactgtg tctactaatg 450
gaagtattca cagcccaagg ttt:cctcata cttatccaag aaatacgc~tc 500
ttggtatgga gat.tagtagc agt.agaggaa aatgtatgga tacaact.t:ac 550
gtttgatgaa agatttgggc ttgaagaccc agaagat:gac atatgcaagt 600
atgattttgt agaagttgag gaacccaatg atggaactat attagggc:gc 650
tggtgtggtt ctggtactgt accaggaaaa cagatttcta aaggaaat.ca 700
aattaggata agatttgtat ctgatgaata tt:ttc:c:t.tc.:t gaaccagggt: 750
tctgcatcca ctacaacatt: qtaatgcc:ac aattc:acaga agctgtgagt 600
ccttcagtgc tacccccttc agcy ttgcca ctggacctgc ttaataatgc 850
tataactgcc ttt.agt.acct tggaagacct t.attcgatat cttgaacc:ag 900
agagatggca gttggactta gaagatctat ataggccaac t.tggcaact.t 950
cttggcaagg cttttgt.t.tt: t:g<:~aagaaaa tccac~agtgg tggatctgaa 1000
ccttctaaca gaggaggtaa gattatac;ag ctgcacacct cgtaacttct 1050
cagtgtccat aagggaagaa ctriaagactaa ccgat.ac:cat t.ttctggc:ca 1100
ggttgtctcc tggttaaacg ctc:~tggtcagg aactqtgcct gttgtctcca 1150
caattgcaat gaatgtcaat gtgtcccaag caaagttact aaaaaatacc 1200
acgaggtcct tcagttgaga ccaaagaccg gtgtc;agggg attccacaaa 1250
tcactcaccg acgtggccct ggagcaccat gaggagtgtg actgtgtgtg 1300
cagagggagc acaggaggat: ag<:cgcat ca c;caccagcag ctct tgccca 1350
gagctgtgca gtgcagtggc tgattctatt agagaacgta tgcgttatct 1400
ccatccttaa tctcagttgt ttgcttc<sag gacctttcat cttcaggat:t 1450
tacagtgcat tctgaaagag gagacatc::aa acagaattag gagttgtgca 1500
acagctcttt tgagaggagg cctaaaggac aggagaaaag gtcttcaatc 2550
gtggaaagaa aattaaatgt tgtatta«at agat<:ac:cag ctagtttcag 1600
agttaccatg tacgtattcc actagctggg ttctgtattt. cagttctttc 1650
gatacggctt agggtaatgt cagtacagga aaaaaactgt gcaagtgagc 1700
acctgattcc gttgccttgc ttaactctaa agctccatgt cctgggccta 1750
aaatcgtata aaatctggat ttt:ttttttt ttttttgctc atattcac:at 1800
326

CA 02421364 2003-03-25
atgtaaacca gaacattcta tgt:actac:aa acctggtttt taaaaaggaa 1850
ctatgttgct atgaattaaa cttgtgtcat gctgatagga cagactgctat 1900
ttttcatatt tcttattaaa atttctgcca t:ttagaagaa gagaactaca 1950
ttcatggttt ggaagagata aacctgaaaa gaagagtggc cttatctt.ca 2000
cttt.atcgat aagtc:agttt atttgtttca tt:gtgtacat ttttatat:tc 2050
tccttttgac attataactg ttggcttttc taatcttgtt aaatatatct 2100
atttt.tacca aaggtattta atattct.ttt tt.atcacaac ttagatcaac: 2150
tatt.tttagc ttggt.aaatt tttct_aaaca caattgttat agccagagga 2200
acaaagatga tataaaatat tgt_tgctctg acaaaaatac atgtattt:ca 2250
ttctcgtatg gtgctagagt ta<~attaarc t:qcattttaa aaaactgaat 2300
tggaatagaa ttggtaagtt gcaaagactt tt:tgaaaata attaaattat 2350
catatcttcc attcctgtta ttc~gagatga aaataaaaag caacttatqa 2400
aagtagacat tcagatccag ccr~ttactaa cc:tattcctt ttttggggaa 2450
atctgagcct agctcagaaa aa<:ataaagc accttgaaaa agacttggca 2500
gcttcctgat aaagcgtgct: gtc~ctgtcaca gtaggaacac atcctatt:ta 2550
ttgtgatgtt gtggttttat: tat:cttaaac t.ctgttccat acac.ttgt:at 2600
aaatacatgg atatttttat gtacagaagt atgtctctta accagttc:ac 2650
ttattgtact ctggcaattt: aaaagaaaat cagtaaaata ttttgctt:gt 2700
aaaatgctta atatngtgcc taggttatgt ggtgactatt tgaatcaaaa 2750
atgtattgaa tcatcaaata aaagaatatg pctattttgg ggagaaaatt. 2800
aaaaaaaaaa aaaaaaaaaa aggt-taggg ataac:agggt aatgcggcc 2899
<210> 988
<211> 395
<212> PRT
<213> Homo sapiens
<400> 988
Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly
1 5 '0 15
Gln Arg Gln Gly Thr Gln Ala G7u Ser A:>n Leu Ser Ser Lys Phe
20 25 30
Gln Phe Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln
3'_~ 90 45
His Glu Arg Ile Ile Thr 'Ja.1 SEr Thr Asn Gly Ser Ile His Ser
50 55 60
Pro Arg Phe Pro His Thr Tyr Pro Arch Asn Thr Val Leu Val Trp
65 ~~0 75
327

CA 02421364 2003-03-25
Arg Leu 'Jal Ala Val Glu C~lu Asn Val Trp Ile Gln Leu Thr Phe
80 85 90
Asp Glu Arg Phe Giy Leu C~lu Asp Prc~ Glu Asp Asp Ile Cys Lys
95 100 105
Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp G1y Thr Ile Leu
110 115 120
Gly Arg Trp Cys Gly Ser <,1y Thr Val Pro Gly Lys Gln Ile Ser
125 130 135
Lys Gly Asr~: Gln Ile Arg =le Arq Phe Val Ser Asp Glu Tyr Phe
140 195 150
Pro Ser Glu Pro Gly Phe Cys Ile His Tyr Asn Ile Val Met Pro
155 160 165
Gln Phe Thr Glu A1a Val Ser Pro Ser Val Leu Pro Pro Ser Ala
170 175 180
Leu Pro Leu Asp Leu heu Asn Asn Ala Ile Thr Ala Phe Ser Thr
185 190 195
Leu G1u Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp Gln Leu
200 2C5 210
Asp Leu Glu Asp Leu Tyr Arg Pro Tt~:r Trp Gln Leu Leu Gly Lys
215 220 225
Ala Phe Val Phe Gly Arg l,ys SEr Arg Val Val Asp Leu Asn Leu
230 235 240
Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe
245 2~~0 255
Ser Val Ser Ile Arg Glu t~lu Leu Lys Arg Thr Asp Thr Ile Phe
260 265 270
Trp Pro Gly Cys Leu Leu ~..~al Lys Arg Cys Gly Gly Asn Cys Ala
275 280 285
Cys Cys Leu His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys
290 295 300
Val Thr Lys Lys Tyr His Glu Val Leu Gl.n Leu Arg Pro Lys Thr
305 310 315
Gly Val Arg Gly Leu His '~ys Ser Leu Thr Asp Val Ala Leu Glu
320 32 5 330
His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser Thr fly Gly
335 340 395
<210> 989
<211> 21
~:212> DNA
<.213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21
328

CA 02421364 2003-03-25
<223> Artificial Sequence
<400> 489
acttCtcagt gtccataagg a ~'1
<210> 490
<:211> 40
<212> DNA
<213> Artificial
<220>
<.221> Artificial Seauence
<222> 1-90
<.223> Artificial Sequence
<400> 990
gaactaaaga gaaccgatac cattttct.gg ccaggtt.gtc 40
<210> 991
<211> 20
<212> DNA
<213> Artificial
«20>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 491
caccacagcg tttaaccagg 20
<210> 492
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 7.-20
<c223> Artificial Sequence
~:900> 492
acaacaggca cagttcccac 20
<210> A93
<27.1> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<:222> 1-21
<223> Artificial Sequence
<400> 993
ggcggaatcc aacctgagta g 21
<210> 999
<211> 20
<212> DNA
<213> Artificial
<220>
32'~

CA 02421364 2003-03-25
<':221> Artificial Sequence
<222> 1-20
c:223> Artificial Sequence
~:400> 999
gcggctatcc tcctgtgctc 20
<210> 995
<211> 3283
<212> DNA
<213> Homo Sapiens
<900> 995
cccatctcaa gctgatcttg gcacctctca t.gctctgctc tcttcaacca 50
gacctctaca ttccattttg gaagaagact aaaaatggtg tttccaatgt 100
ggacactgaa gagacaaatt cttatccttt ttaac:ataat cctaatttcc 15C
aaactccttg gggctagatg gtt,tcctaaa actctgccct gtgatgtc:ac 200
tctggatgtt ccaaagaacc atgtgatcgt ggactgcaca gacaagcatt 250
tgacagaaat tcctggaggt: attcccac:ga ac:accacgaa cctcaccctc 300
accattaacc acataccaga catctcccca gcgtc:ctttc acagactgga 350
ccatctggta gagatcgatt: tc<sgatgcaa c:tgtgtacct attccactgg 900
ggtcaaaaaa caacatgtgc: atcaagaegc tgcagattaa acccagaagc 450
tttagtggac tcacttattt aaaatccc:tt t.acctggatg gaaaccagct 500
actagagata ccgcagggcc tc;~cgcctag cttacagctt ctcagccttg 550
aggccaacaa catcttttcc atcagaaaag agaatctaac agaactggcc 600
aacatagaaa tactctacct gggccaaaac t:gttattatc gaaatccttg 650
ttatgtttca tattcaatag agaaagatgc cttcctaaac ttgacaaagt 700
taaaagtgct ctccctgaaa gataacaatg tcacagccgt ccctactgtt 750
ttgccatcta ctttaacaga ac~atatc:ac t.acaacaaca tgat:.tgcaaa 800
aatccaagaa gatgatttta ataacctc:aa ccaattacaa attcttgacc 850
taagtggaaa ttgccctcgt tgttataatg ccccatt:tcc ttgtgcgccg 900
tgtaaaaata attctcccct acagatc~::ct gtaaatgctt ttgatgcgct 950
gacagaatta aaagttttac gtctacacag t.aactctctt cagc:atgtgc 1000
ccccaagatg gtttaagaac atcaacaaac tccaggaact ggatctgtcc 1050
caaaacttct tggccaaaga aattgggcat gctaaatttc t.gcattttct 1100
ccccagcctc atccaattgg atctgtcrtt caattttgaa c:ttcaggtct 1150
atcgtgcatc tatgaatcta tcacaagc:at tttctt;~act gaaaagcctg 1200
aaaattct.gc ggatcagagg atatgtcttt aaagagttga aaagctttaa 1250
330

CA 02421364 2003-03-25
cctctcgcca ttacataatc ttcaaaatct t:gaagttctt gatcttggca 1300
ctaactttat aaaaattgct aacct:cagca tgtttaaaca atttaaaaga 1350
ctgaaagtca tagatctttc agtgaataaa atatcacctt caggagattc 1400
aagtgaagtt ggcttctgct caaat:gc:cag aacttctgta gaaagttatg 1950
aaccccaggt cctggaacaa ttacattatt tcagatatga taagtatgca 1500
aggagttgca gattcaaaaa caaagaggct t.ctttcatgt ctgttaatga 1550
aagctgctac aagtatgggc agacc:ttgga tc;taagt.aaa aatagtatat 1600
tttttgtcaa gtcctctgat tttcagcatc t.ttctttcct caaatgcctg 1650
aatctgtcag gaaatctcat taqccaaact ct:taatggca gtgaatt<:ca 1700
acctttagca gagctgagat atttggactt ctccaacaac cggcttgatt 1750
tactccattc aacagcattt gaaga gcttc acaaact:gga agttctggat 1800
ataagcagta atagccatta ttttcaatca gaagcaatta ctcatatgct 1850
aaactttacc aagaacctaa age;ttctgca gaaactgatg atgaacgaca 1900
atgacatctc ttcctccacc agcaggacca tggagagtga gtctcttaga 1950
actctggaat tcagaggaaa tcacttagat gt:tttatgga gagaaggtga 2000
taacagatac ttacaattat tcaagaatct <~ctaaaatta gaggaatt:ag 2050
acatctctaa aaatt.cccta agt:ttcttgc cttctggagt ttttgatggt 2100
atgcctccaa atctaaagaa tct:ctctttg gccaaaaat.g ggctcaaatc 2150
tttcagttgg aagaaactcc agtgtctaaa gaaccaggaa actttggacc 2200
tcagccacaa ccaactqacc: acrgtccctg ac~agat:tatc caactgttcc 2250
agaagcctca agaatctgat. tcttaaga:at aatcaaatca ggagtctgac 2300
gaagtatttt. ctacaagatg ccttccar,tt gcgatat:ctg gatctcagct 2350
caaataaaat ccagatgatc: caaaagaoca gcttc:cc;aga aaatgtc~:~tc 2900
aacaatctga agatgttgct ttt.gcatcat aatcggtttc tgtgcacct.g 2450
tgatgctgtg tggtttgtct ggtg~~gtt as ccatacc4gag gtgactattc 2500
cttacctggc cacagatgtg acttgtgtgg ggccaggagc acacaagggc 2550
caaagtgtga tctccctgga tct:gtaca-~cr_ tgtgagttag atct:gacr:aa 2600
cctgattctg ttctcacttt ccatatctgt atctctcttt ctcatggtga 2650
tgatgacagc aagtc:accts tatttctggg atgtgtggta tatttaccat 2700
ttctgtaagg ccaagataaa ggggtatc:ag cgtctaatat caccagactg 2750
ttgctatgat gcttttattg tg~~atgacac t:aaagaccca gctc~tgaccg 2800
agtgggtttt ggctgagctg gtggccae:ac tggaagaccc aagagagaaa 2850
331

CA 02421364 2003-03-25
cattttaatt tatgtctcga ggaaagggac tggttaccag ggcagccagt 2900
tctggaaaac ctt.tcccaga gcGtacagct t.agcaaaaag acagtgtttg 2950
tgatgacaga caagtatgca aagactgaaa at:.t:ttaagat agcattttac 3000
ttgtcccatc agaggctcat gga.tgaaaaa gt.t:gatgt.ga ttatcttoat 3050
atttcttgag aagccctttc agaagtccaa gt:tcctccag ctccggaaaa 3100
ggctct.gtgg gagttctgtc: cttgagtggc caacaaaccc gcaagctc:ac 3150
ccatacttct ggc:agtgtct aaagaacgcc ctggccacag acaatcatgt 3200
ggcctatagt caggtgttca aggaaacg:at c;tagcccttc tttgcaaaac 3250
acaactgcct agtttaccaa ggagaggcct ggc 3283
<:210> 996
<211> 1099
<212> PRT
<.213> Homo sapiens
<400> 496
Met Val Phe Pro Met Trp 7'hr Lea Lys Arg Gln Ile Leu Ile Leu
1 5 10 15
Phe Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe
20 25 30
Pro Lys Thr Leu Pro Cys F.sp Val Thr Leu Asp Val Pro Lys Asn
35 40 45
His Val Ile Val Asp Cys 'Thr Asp Lys His Leu Thr Glu Ile Pro
50 55 60
Gly Gly Ile Pro Thr Asn Thr TY<r Asn Leu Thr Leu Thr Ile Asn
65 70 75
His Ile Pro Asp Ile Ser Pra Ala Ser Phe His Arg Leu Asp His
ao s5 90
Leu Val Glu Ile Asp Fhe Arg Cys Asn Cys Val Pro Ile Pro Leu
95 1C0 105
Gly Ser Lys Asn Asn Met C'ys Ile Lys Arg Leu Gln Ile Lys Pro
110 115 120
Arg Ser Phe Ser Gly Leu Thr Tyr Leu Lys Ser Leu Tyr Leu Asp
125 10 135
Gly Asn Gln Leu Leu Glu lle Fro Gln Gly Leu Pro Pro Ser Leu
190 19w 150
Gln Leu Leu Ser Leu Glu Ala An Asn Ile Phe Ser Ile Arg Lys
155 1E~0 165
Glu Asn Leu Thr Glu Leu Ala Asn 11.e Glu Ile Leu Tyr Leu Gly
170 115 180
Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser Tyr Ser Ile
185 190 195
332

CA 02421364 2003-03-25
Glu Lys Asp Ala Phe Leu I~a n Leu Thr Lys Leu Lys Val Leu Ser
200 205 210
Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro Ser
215 220 225
Thr Leu Thr Glu Leu Tyr L,eu Tyr Asn Asn Met Ile Ala Lys Ile
230 235 290
Gl.n Glu Asp Asp Phe Asr. Asn Leu Asn Gln Leu Gln Ile Leu Asp
245 250 255
Leu Ser G1y Asn Cys Pro Arg Cys 'I'yr Asn Ala Pro Phe Pro Cys
26C 265 270
Ala Pro Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala
275 280 285
Phe Asp Ala Leu Thr Glu I,eu Lys Val Leu Arg Leu His Ser Asn
290 295 300
Ser Leu Gln His Val Pro Pro Arg 'Irp Phe Lys Asn Iie Asn Lys
305 310 315
heu Gln Glu Leu Asp heu Ser Gln Asn Phe Leu Ala Lys Glu I1e
320 325 330
Gly Asp Ala Lys Phe Leu His PY:e Leu Pro Ser Leu Ile Gln Leu
335 390 345
Asp Leu Ser Phe Asn Phe G1u Leu Gln Val Tyr Arg Ala Ser Met
350 355 360
Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser Leu Lys Ile Leu
365 370 375
Arg Ile Arg Gly Tyr Val F'he Lys Glu Leu Lys Ser Phe Asn Leu
380 3E?5 390
Ser Pro Leu His Asn Leu Gln Asn Leu G7u Val Leu Asp Leu Gly
395 900 405
Thr Asn Phe Ile Lys I:le Ala A:n Leu Ser Met Phe Lys Gl.n Phe
910 975 920
Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys Ile Ser Pro
925 930 935
Ser Gly Asp Ser Ser Glu '.Jal G:.y Phe Cys Ser Asn Ala Arg Thr
440 945 950
Ser Val Glu Ser Tyr Glu Pro Gn Val Leu Glu Gln Leu His Tyr
455 4E>0 965
Phe Arg Tyr Asp Lys Tyr Ala Aag Ser Cys Arg Phe Lys Asn Lys
970 4?5 980
Glu Ala Ser Phe Met Ser 'Jal A~u Glu SEer Cys Tyr Lys Tyr Gly
485 990 495
Gln Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Fhe Val hys Ser
500 505 510
333

CA 02421364 2003-03-25
Ser Asp Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser
515 520 525
Gly Asn Leu Ile Ser G1n Thr Leu Asn Gly Ser Glu Phe Gln Pro
530 5 .5 540
Leu Ala Glu Leu Arg Tyr Leu A_p Phe Ser Asn Asn Arg Leu Asp
595 550 555
Leu Leu His Ser Thr Ala Phe GLu Gl,z Leu His hys Leu Glu Val
560 565 570
Leu Asp Ile Ser Ser Asn Bier Hs Tyr Phe Gln Ser Glu Gly Ile
575 580 585
Thr His Met Leu Asn Phe Thr Lys Asn Leu Lys Val Leu G1n Lys
590 595 60C
Leu Met Met Asn Asp Asn Asp Tle Ser Ser Ser Thr Ser Arg Thr
605 670 615
Met Glu Ser Glu Ser Leu Arg Thr Leu Glu Phe Arg Gly Asn His
620 625 630
Leu Asp Val Leu Trp Arg Gl-s Gly Asp Asn Arg Tyr Leu Gln Leu
635 690 645
Phe Lys Asn Leu Leu Lys Leu Giu Glu Leu Asp Lle Ser hys Asn
650 655 660
Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly Met Pro Pro
665 6''0 675
Asn Leu Lys Asn Leu Ser Leu Aa Lys Asn Gly I~eu Lys Ser Phe
680 685 690
Ser Trp Lys Lys Leu Gln !Jys Lc~u L ys Asn Leu Glu Thr Leu Asp
695 700 705
Leu Ser His Asn Gln Leu Thr Thr Val Pro G1u Arg Leu Ser Asn
710 7_~5 720
Cys Ser Arg Ser Leu Lys Asn heu I've Leu Lys Asn Asn Gln I1e
725 7B0 735
Arg Ser Leu Thr Lys Tyr Phe Lc-u Gln Asp Ala Phe Gln Leu Arg
790 795 750
Tyr Leu Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gin Lys Thr
755 760 765
Ser Phe Pro Glu Asn Val Leu A:sn As:~ Leu Lys Met Leu Leu Leu
770 7'75 780
His His Asn Arg Phe Leu Cys Thr Cys A:>p A1a Val Trp Phe Val
785 790 795
Trp Trp Val Asn His Thr Glu Vai '?'hr Iie Pro Tyr Leu Aia Thr
800 805 810
Asp V al Thr Cys Val Gly Pro Giy Ala H.is Lys Gly Gln Ser Val
815 8:?0 825
3~j9

CA 02421364 2003-03-25
Ile Ser Leu Asp Leu Tyr ~'hr C}~~s Glu Leu Asp Leu Thr Asn Leu
830 8~.5 890
Ile Leu Phe Ser Leu Ser Iie Ser Val Se:r Leu Phe Leu Met Val
895 850 855
Met Met Thr Ala Ser His L.eu 'ryr FOe TrP: Asp Val Trp Tyr Ile
860 865 870
Tyr His Phe Cys Lys Ala Lys Ile l.ys Gly Tyr Gln Arg Leu Ile
8'75 880 885
Ser Pro Asp Cys Cys Tyr Asp Ala Prue Ile Val 'Iyr Asp Thr Lys
890 895 900
Asp Pro Ala Val Thr Glu Trp Val heu Ala Glu Leu Val Ala Lys
905 910 915
Leu Glu Asp Pro Arg Glu Lys Hps Phe Asn Leu Cys Leu Glu Glu
920 9~' '; 930
Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln
935 990 995
Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys
950 955 960
Tyr Ala Lys Thr G.lu Asn Phe Lys I:le Ala Phe Tyr Leu Ser His
965 970 975
Gln Arg Leu Met Asp Glu ~y5 Va,l Asp Val Ile Ile Leu Ile Phe
980 985 990
Leu Glu Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys
995 1000 1005
Arg Leu Cys Gly Ser Ser 'Jal Leu Glu Trp Pro Thr Asn F'ro Gln
1010 105 1020
Ala His Pro Tyr Phe Trp Cln Cys Leu Lys Asn Ala Leu Ala Thr
1.02.5 10 30 1035
Asp Asn His Val Ala Tyr Ser Gln Val Pt:e Lys Glu Thr Val
1090 10~1_'~
<210> 497
<211.> 9199
<2i2> DNP,
<213> Homo sapiens
<900> 49i
gggtaccatt ctgcgctgct gcaagttacg gaat<xaaaaa t.tagaacaac 50
agaaacatgg aaaacatgtt cc~;tcagtcg tcaai_gctga cctgcatttt 100
cctgctaata tctggttcct gtgagttatg cgccgaagaa aattttt~uta 150
gaagctatcc ttgtgatgag aaaaagct,;aa atgactcagt tattgcagag 200
tgcagcaatc gtcgactaca ggaagttccc caaacggtgg gcaaatatgt 250
gacagaacta qacctgtctg ataatttcat cacacacata acgaatgaat 300
?3'~

CA 02421364 2003-03-25
catttcaagg gctgcaaaat ctcactaaaa taaatctaaa ccacaacccc 350
aatgtacagc accagaacgg as<it<:ccqgt atacaat.caa atggcttctaa 400
tatcacagac ggggcattcc tcaac.:ctaaa aaacctaagg gagttactgc 450
ttgaagacaa ccagttaccc: ca<~atacc:ct ct:ggtttgcc agagtctt:tg 500
acagaactta gtctaattca aaacaatata tacaacataa ctaaagaggg 550
catttcaaga cttataaact: tgaaaaatct ctatttqgc:c tggaactc~ct 600
attttaacaa agtttgcgag aauactaGca t.agaagatgg agtatt:tgaa 650
acgctgacao atttggagtt: gct;atcacta tctttcaatt ctctttcaca 700
cgtgccaccc aaactgccaa gct.ccctacg caaactvtt:t ctgagcaaca 750
cccagatcaa atacattagt gaagaagatt tcaagggatt gataaattta 800
acattactag atttaagcgg garzctgtc:cg <~ggtctcttca atgccccatt 850
tccatgcgtg ccttgtgatg gtggtgcttc aattaatata gatcgttttg 900
cttttcaaaa cttgacccaa cttcg atacc tasaac:ctctc tagcacttcc 950
ctcaggaaga ttaatgctgc ctggtttaaa aatat.gcctc atctgaaggt 1000
gctggatctt gaattcaact= atttagtqgg agaaatagtc tctggggcat 1050
ttttaacgat gctgccccgc tt~agaaatac t:tgacatgtc t:tttaactat 1100
ataaagggga gttatccaca gcata ttaat atttccagaa acttctctaa 1150
acttttgtct ctacgggcat tgcattt<_ag aggtt:atgtg ttcc:aggaac 1200
tcagagaaga tgatttccag cccctgaigc agcttccaaa cttatcgact 1250
atcaacttgg gtattaattt r_attaag<aa a~tcgatttca aacttttcca 1300
aaatttctcc aatctggaaa ttatttac:tt gtcagaaaac agaatatcac 1350
cgttggtaaa agatacccgg cac.~agtt<zta caaat:agttc ctcttt.tcaa 1900
cgtcatatcc ggaaacgacg ctcaacaqat tttg<:gtttg acccacattc 1450
gaacttttat catttcaccc gtcctttaat aaagccacaa tgtgctgctt 1500
atggaaaagc: cttagattta agcctcaa-aca gtattttctt cattgggcca 1550
aaccaatttg aaaatcttcc tgacattgcc tgttl=aaatc tgtctgcaaa 1600
tagcaatgct:. caagtgttaa gtggaactga attttcaqcc attcct.catq 1650
tcaaatattt ggatttgaca aacaatagac tagactttga taatgctagt 1700
gctcttactg aattgtccga ctt.ggaac~t t ctagatctca c7ctataattc 1750
acactatttc agaatagcag gcgtaacaca tcatctagaa tttattcaaa 1800
atttcacaaa tctaaaagtt ttaaacttga gccacaacaa catttatact 1850
336

CA 02421364 2003-03-25
ttaacagata agtataacct ggaaagcaag tccctggtag aattagtttt 1900
cagtggcaat cgcct.tgaca tttt:gtggaa tgatgatgac aacaggtata 1950
tctccatttt caaaggtctc aagaatctga cacgtctgga tttatccctt 2000
aataqgctga agcacatccc aaatgaagca t.tc~cttaat,t tgccagcgag 2050
tctcactgaa ctacatataa atcrat:aatat. gt;taaagttt tttaactgga 2100
cattactcca gcagtttcct cgtct:cgagt tgcttgactt acgtggaaac 2150
aaactactct ttttaactga tac;c<:tatct gactttacat cttcccttcg 2200
gacactgctg ctgagtcata acaggatttc ccacctaccc tctggctttc 2250
tttctgaagt cagtagtctg aagcacctcg attaaagttc caat,ctgca.a 2300
aaaacaatca acaaatccgc acttgaacct aagaccacca ccaaattatc 2350
tatgttggaa ctacacggaa acc:cctttga cstgcacctgt gacattggag 2400
atttccgaag atggatggat gaacatctga atgtcaaaat tcccagactg 2950
gtagatgtca tttgtgccag tcctggggat c:aaagaggga agagtattgt 2500
gagtctggag ctaacaactt. gt<ttttcaga tgtcactgca gtgatatt:at. 2550
ttttcttcac: gttctttatc accaccatgg ttatgtt:ggc tgccctggc:t 2600
caccatttgt tttactggga tgtti=ggttt atatataatg tgtgtttagc 2650
taaggtaaaa ggctacaggt ctctttccac atcccaaact ttctatgatg 2700
cttacatttc ttatgac acc: aaa gatgcct ctgtta<vtga ctgggtgata 2750
aatgagctgc gctaccacct tgaagagagc cgagacaaaa acgttctcct 2800
ttgtctagag gagagggatt gggac:cccrgg att.ggccatc atcgacaacc 2850
tcatgcagag catcaaccaa ag<:aagaaaa cagtatttgt tttaaccaaa 2900
aaatatgcaa aaagc:tggaa ctttaaaa,ca gc:ttt tt:act tgg<attgca 2950
gaggctaatg gatgagaaca tgg atgtqat t:atat:t:tatc ctgctggagc 3000
cagtgttaca gcatt:ctcag tatttgacgc tacgdcagcg gatctgtaag 3050
agctccatcc tccagtggcc: tgacaacccg aaggcagaag gcttgttttg 3100
gcaaactctg agaaatgtgg tcttgactga aaatgattca cggtataaca 3150
atatgtatgt cgatt:ccatt aagcaata:ct aactga~:vgtt aagtcatgat 3200
ttcgcgccat aataaagatg caaagga<:tg acatttctgt attagttatc 3250
tattgctatg taacaaatta tcccaaaact t.agtg gt.tta aaacaacaca 3300
tttgctggcc cacagttttt gagggtcagg agtcc:aggcc cagcataact 3350
gggtcctctg ctcagggtgt ctcagagctct gcaai:gtagg tgttcaccag 3400
agacataggc atcactgggg tcacactcat gtggi:tgttt t.ctggattca 3950
33-i

CA 02421364 2003-03-25
attcctcctg ggctattggc caaaggctat ar_.tcatqtaa gccatgcgag 3500
cctctcccac aaggcagctt gcttcatcag agctagcaaa aaagagaggt 3550
tgctagcaag atgaagt~ac aat:cttttgt aatcgaatca aaaaagtgat 3600
atctcatcac tttggccata ttrtatttgt t.agaagtaaa ccacaggtcc 3650
caccagctcc atgggagtga ccacctcagt ccagggaaaa cagctgaaga 3700
ccaagatggt gagctctgat tgett=cagtt ggtcatc:aac tattttccct 3750
tgactgctgt cctgggatgg cctgctatca t:g<stgataga ttgtgaatat 3800
caggaggcag ggatcactgt ggacc:atctt agc.agttgac ctaacacatc 3850
ttcttttcaa tat.ctaagaa cttttgcc:ac tgtgactaat ggtcctaata 3900
ttaagctgtt gtttatattt at<:.atat.atc t:atggctaca tggttatatt 3950
atgctgtggt tgcgttcggt tttatttac:a gttgctttta caaatatttg 4000
ctgtaacatt tgacttctaa ggtttagatg cc:atttaaga actgagatgg 9050
atagctttta aagcatcttt tac:tt:cttac c.attttt:taa aagtatgc:ag 4100
ctaaattcgo agcttttggt ctzitattgtt aattgccatt gctgtaaatc 9150
ttaaaatgaa tgaataaaaa tgtttcattt tacaaaaaaa aaaaaaaaa 4199
<210> 998
<211> 1091
<21.2> PRT
<213> Homo Sapiens
<::400> 498
Met Glu Asn Met Phe Leu (~ln Ser Ser Met Leu T'hr Cys Ile Phe
10 15
Leu Leu Ile Ser Gly Ser (.",ys Gnu Leu Cys Ala Glu Glu Asn Phe
20 25 30
Ser Arg Ser Tyr Pro C:ys Asp Glu Lys Lys Gln Asn Asp Ser Val
35 40 95
Ile Ala Glu Cys Ser Asn Flrg Arg Leu Gl n Glu Val Pro G'ln Thr
50 55 60
Val Gly Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn PYie Ile
65 70 75
Thr His Ile Thr Asn Glu Ser PY!e Gln Gly Leu Gln Asn Leu Thr
80 85 90
Lys Ile Asn Leu Asn His Asn Pro Asn Val Gln His Gln Asn Gly
95 100 105
Asn Pro Gly Ile Gln Ser Asn Gl.y Leu Asn Ile Thr Asp Gly Ala
110 115 120
Phe Leu Asn Leu Lys Asn Lea Arg Glu Leu Leu heu Glu Asp Asn
125 1;'s0 7 35
338

CA 02421364 2003-03-25
Gln Leu Pro Gln Il.e Pro Ser Gly Leu Pro Glu Ser Leu Thr Glu
190 145 150
Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn Ile Thr Lys Glu Gly
255 160 165
Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr Leu Al.a Trp Asn
170 175 180
Cys Tyr Phe Asn Lys 'Jal Cys Gln Lys Thr Asn Ile Glu Asp Gly
185 190 195
Val Phe Glu Thr Lea Thr ~~sr~ Leu GlLn Leu Leu Ser Leu Ser Phe
200 20~: 210
Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu Arg
'215 220 225
Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Iie Ser Glu Glu
230 235 290
Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly
2_.45 250 255
Asn Cys Pro Arg Cys Phe Asn Ala Fro Pre Pro Cys Val Pro Cys
260 265 270
Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn
275 2E0 285
Leu Thr Gln l,eu Arg Tyr heu Asn Leu Ser Ser Thr Ser Leu Arg
290 295 300
Lys Ile Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu Lys Val
305 310 315
Leu Asp Leu Gl.u Phe Asn '1'yr LEU Vai Gly Glu Ile Val Ser Gly
320 325 330
Ala Phe Leu Thr Met Leu Pro Arg I~eu Glu Ile Leu Asp Leu Ser
335 390 395
Phe Asn Tyr Iie Lys Gly Ser Tyr Fro Gln His Ile Asn Ile Ser
350 355 360
Arg Asn Phe Ser Lys Leu Leu Ser Leu Arq Ala Leu His Leu Arg
365 3:'0 375
Gly Tyr Val Phe Gln Glu Leu Arg Glu Asp Asp Phe G1n Pro Leu
X80 385 390
Met Gln Leu Pro Asn Leu Ser Tt:r Il.e Asn Leu Gly Il.e Asn Phe
395 400 905
Ile Lys Glr. Ile Asp Phe Lys LE~u Phe G-n Asn Phe Ser Asn Leu
41 0 9 _.5 420
Gl.u Ile Ile Tyr Leu Ser GIu A:>n Arg Ile Ser Pro Leu Val Lys
925 930 435
Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His
440 995 950
339

CA 02421364 2003-03-25
Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser
45', 460 965
Asn Phe Tyr His Phe Thr Arg Pro Let. Ile Lys Pro Gln Cys Ala
970 975 480
Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe
98w 490 495
Ile Gl.y Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu
500 505 510
Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu
515 520 525
Phe Ser Ala Ile Pre His Va_ Lys Tyr Leu Asp Leu Thr Asn Asn
530 535 540
Arg Leu Asp Phe Asp Asn Flla Ser i~l.a Leu T'hr Glu Leu Ser Asp
545 550 555
Leu Glu Vas L~eu Asp Leu Ser Tyr Asn Ser Hi.s Tyr Phe Arg Ile
560 SE~: 570
Ala Gly Val Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn
575 580 565
Leu Lys Val Leu Asn Leu Ser His Asn Asn Ile Tyr Thr Leu Thr
590 595 600
Asp Lys Tyr Asn Leu Glu ,'3e; Lys Ser Leu Val Glu Leu Val Phe
605 610 615
Ser Gly Asn Arg Leu Asp =l:lc= Leu Trp A:;n Asp Asp Asp Asn Arg
620 625 630
Tyr Ile Ser Ile Phe Lys Gly LE-a Lys A~:n Leu Thr Arg Leu Asp
635 690 645
Leu Ser Leu Asn Arg Leu »ys His Ile Fro Asn Glu Ala Fhe Leu
650 6'_;5 660
Asn Leu Prc A.la Ser T~eu Thr Glu Leu His I:Le Asn Asp Asn Met
665 6;0 675
Leu Lys Phe Phe Asn Trp Thr LE-a Len Gln G.ln Phe Pro Arg Leu
680 685 690
Glu Leu Leu Asp Leu Arg Gly A;;n Lys Leu Leu Fhe Leu Thr Asp
695 700 705
Ser Leu Ser Asp Phe Thr S er Ser Leu Arg Thr Leu Leu Leu Ser
7i0 7_5 720
His Asn Arg Ile Ser His Leu Pro Ser G=~y Phe Leu Ser Glu Val
725 730 735
Ser Ser Leu Lys Hi.s Leu Asp LE~u Ser Ser Asn Leu Leu Lys Thr
740 795 750
Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser
755 760 765
3 9 ~~

CA 02421364 2003-03-25
Met Leu Glu Leu His Gly Asn Pro I?he Glu Cys Thr Cys Asp Ile
770 775 780
Gly Asp Phe Arg Arg 'I'rp Met. Asp Glu His Leu Asn Val Lys Ile
785 790 795
Pro Arg Leu Val Asp Va1 Ile Cys Ala Se-r Pro Gly Asp Gln Arg
800 805 810
Gly Lys Ser Lle Val Ser Leu G1 a Leu Tl-:r 7.'hr Cys Val Ser Asp
815 8~0 825
Val Thr Aia Val Ile Leu I?he Pk~e Ftie Thr Phe Phe Ile Thr Thr
830 8~;5 840
Met Val Met Leu Ala Ala l.~eu Alaj His His Leu Phe Tyr Trp Asp
845 8'_~0 855
Val Trp Phe Ile Tyr Asn Va:1 Cys Leu Ala Lys Val Lys Gly Tyr
860 865 870
Arg Ser Leu Ser Thr. Ser Gln Thr Phe Tyr Asp Al.a Tyr Ile Ser
875 880 885
Tyr Asp Thr Lys Asp A.la Ser Val Thr Asp Trp Val Ile Asn Glu
890 895 900
Leu Arg Tyr His Leu Glu (:~lu Ser Arg Asp Lys Asn Val Leu Leu
905 97_0 915
Cys Leu Glu Glu Arg Asp 'Lrp Ap Pro G'_y Leu Ala Ile Il.e Asp
920 92 5 930
Asn Leu Met Gln Ser Ile Asn Gln Se:r Lys Lys Thr Val Fhe Val
9 5 940 945
Leu Thr Lys Lys Tyr Ala Lys SE~r Tr.p A;n Phe hys Thr Ala Phe
950 9'.5 960
Tyr Leu Ala Leu Gln Arg l_~eu Mf.~t Asp Glu Asn Met Asp Val Ile
965 9'70 975
Iie Phe Ile Leu Leu Glu Pro V;:cl Leu GLn His Ser Gln Tyr Leu
980 985 990
Arg Leu Arg Gln Arg Ile '~ys Lys Ser Ser Ile T~eu Gln Trp Pro
995 10()0 1005
Asp Asn Prc Lys Ala Glu Gly Lc:u Phe Trp Gln Thr Leu Arg Asn
1010 1015 1020
Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val
1025 1030 1035
Asp Ser Ile L:ys Gln 'ryr
1040
<210> 499
<211> 20
<212> DNA
<213> Artificial
391

CA 02421364 2003-03-25
<220>
<221> Artificial Sequence
<222> 1-2.0
<223> Artificial Seauence
<400> 499
taaagaccca gctgtgaccg 20
<210> 500
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<900> 500
atccatgagc ctctgatggg 20
<210> 501
~211> 95
<2i2> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-45
<223> Artificial Sequence
<900> 501
atttatgtct cgaggaaagg gactggttac cagggcagcc agttc 95
<210> 502
<211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21
<223> Artificial Sequence
<400> 502
gccgagacaa aaacgttctc c 21
<210> 503
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequa_nce
<222> 1-24
<223> Arti.fi.cial Sequence
<900> 503
catccatgtt ctcatccatt agcc 29
<210> 509
<211> 96
<212> DNA
392

CA 02421364 2003-03-25
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-46
<223> Artificial Sequence
<400> 504
tcgacaacct catgcagagc atcaaccaaa gcaagaaaac agtatt 46
<210> 505
<211> 1738
<212> GNA
<213> Homo sapiens
<900> 505
ccaggtccaa ctgcacctcg gttctatc:la ttgaattccc cggggatc:ct 50
ctagagatcc ctcgacctcd acccacgcgt ccgccaagct ggccctgcac 100
ggctgcaagg gaggctcctg tggacagg:c aggcaggtgg gcctcaggag 150
gtgcctccag gcggccagtg ggcctgaggc ccc:agcaagg gctagggtcc 200
atctccagtc ccaggacaca gcagcggcca ccatggccac gcctgggctc 250
cagcagcatc agcagccccc aggaccgggg aggcacaggt ggcccccacc 300
acccggagga gcagctcctg ccc.ctgtccg ggggatgact gattctcctc 350
cgccaggcca cccagaggag aaqgccaccc cgcctggagg cacaggccat 900
gaggggctct caggaggtgc tgc-tgatgtg gcttctggtg ttggcagtgg 450
gcggcacaga gcacgcctac cggcccggcc gt:agggtgtg tgctgtccgg 500
gctcacgggg accctgtctc cgagt=cgttc gtgcagcgtg tgtaccagcc 550
cttcctcacc acctgcgacg qgc:accgggc. ~tgcagc:acc taccgaacca 600
tctataggac cgcctaccgc cgcagccctg ggctggcccc tgccaggcct 650
cgctacgcgt gctgccccgg ctcagaagagg accagcgggc ttcctggggc 700
ctgtggagca gcaatatgcc agc:c<xccatg ccggaacgga gggagctgtg 750
tccagcctgg ccgctgccgc: tgc:cctgcag gatggcc,~ggg tgacactt=gc 800
cagtcagatg tggatgaatg cagtgctagg ag gggcggct gtccccagcg 850
ctgcatcaac accgccggca gtt:.act.ggtg c:cagtgt:tgg gaggggca ca 900
gcctgtctgc agacggtaca ctctgtgtgc ccaagggagg gccccccagg 950
gtggccccca acccgacagg agtggacagt gcaatgaagg aagaagtgca 1000
gaggctgcag tccagggtgg acctgctgga ggagaagctg cagctggtgc 1050
tggccccact gcacagcctg gcctcgcagg cactggagca tgggctcccg 1100
gaccccggca gcctcctggt gcactccttc cagcagctcg gccgcatcga 1150
ctccctgagc gagcagattt cctt~~ctUga ggagcagctg gggtcctgct 1200
393

CA 02421364 2003-03-25
cctgcaagaa agactcgtga ctgcccagcg ccccaggca g gactgagccc 1250
ctcacgccgc cctgcogccc ccatgccc:~t gc:c:caacatg ctgggggtcc 1300
agaagccacc tcggggtgac tgagcggaag gccaggcagg gccttcctcc: 1350
tcttcctcct ccccttcctc gggaggctcc cc:agacc<:tg gcatgggatg 1400
ggctgggatc ttctct:gtga atc<:acccct ggctaccccc accctggcta 1950
ccccaacggc atcccaaggc caggtgggcc ct.cagctgag ggaaggtacg 1500
agctccctgc tggagcctgg gac:ccatg~c acaggccagg cagcccggag 1550
gctgggtggg gcctcagtgg ggc:ctgct:g c ctgaccccca gcacaataaa 1600
aatgaaacgt gaaaaaaaaa aa<:aaaaaaa aaaaaaaaaa a,saaaaaoaa 1650
aaagggcggc cgcgactcta gagtcgact gcagaagctt ggccgccatg 1700
gcccaacttg tttattgcag cttat:aatgg ttacaaat 173
<210> 506
<211> 273
<212> PRT
<213> Homo Sapiens
<400> 506
Met Arg Gly Ser Glr: Glu Val Leu Leu Met Trp Leu Leu Val Leu
1 ~ 10 15
Ala Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val
20 25 30
Cys Ala Val Arg Ala His Gly Asp Fro Val Ser Glu Ser Phe Val
35 90 45
Gln Arg Val Tyr Gln Fro F'he Leu Thr Thr Cys Asp Gly His Arg
0 ' 60
Ala Cys Ser Thr Tyr Arg ,'hr Lle Tyr Arg Thr AIa Tyr Arg Arg
65 i0 75
Ser F'ro Gly Leu Ala Pro Ala Arg Fro Arc, 'T'yr Ala Cys Cys Pro
80 85 90
Gly Trp Lys Arg Thr Ser my Leu Pro Gly Ala Cys Gly Ala Ala
95 100 105
Ile Cys Gln Fro Pro C;ys Arcl A:,n Gly Gly Ser Cys Val Gln Fro
110 115 120
Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln
125 1 30 135
Ser Asp Val Asp Glu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln
190 145 150
Arg Cys Ile Asn Thr Ala Gly Seer Tyr Trp Cys Gln Cys Trp Glu
155 160 165
Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys Val Pro Lys Gly
394

CA 02421364 2003-03-25
1'70 175 180
Gly Pro Pro Arg Val Ala Frc> Asn Prc> Thr Gly Val Asp Ser Ala
185 190 195
Met Lys Glu Glu Vai ~ln Arq_ Leu Glni Ser Arg Val Asp Leu Leu
200 205 210
Glu Glu Lys Leu Gln Leu ~.'al Leu Ala Pro Leu His Ser Leu Ala
21c~ 220 225
Ser Gln Ala Leu Glu His: Cly Leu Fro Asp Pro Gly Ser Leu Leu
2 30 23'_~ 240
Val His Ser Phe Gln Gln L~eu Gly Arg Ile Asp Ser Leu Ser Glu
~95 25C? 255
Gln Ile Ser Phe Leu Glu C~lu Gln hc:u Gly Ser Cys Ser Cys Lys
260 265 270
Lys Asp Ser
<210> 507
<211> 1700
<212> DNA
<:213> Homo sapiens
<90C> 507
gccaggcagg tgggcctcag gac~gtgcctc caggc:ggcca gtgggcctga 50
ggccccagca agggctaggg tcc:atctcca gtcccaggac acagcagcgg 100
ccaccatggc cacgcctggg ct~:cagcagc atcagagcag cccc.tgtggt 150
tggcagcaaa gttcagcttg gctgggcccg ctgtgagggg cttcgcgct.a 200
cgccctgcgg tgtcccgagg gctgaggtct cctcat<a tc tcccaagcag 250
tggatgagca acccaacggg gg<;ccggcga gggg<iactgg cccc.:gaggga 300
gaggaacccc aaagccacat ctgtagc<:ag gatgagcagt gtgaatccag 35C
gcagccccca ggaccgggga ggcacaggtg gcccccacca ccccxgaggag 400
cagctcctgc ccctgtccgg gggatgacag attctcctcc gccaggccac 950
ccagaggaga aggccacccc gcctggacagc acaggcc:atg aggggctctc 500
aggaggtgct gctgatgtgg cttctggv.gt tggc<3gtggg r:ggcacagag 550
cacgcctacc ggcccggccg tagggtg?.gt gctg-cc:ggg cacacgggga 600
ccctgtct.cc gagtcgttcg tgcagcgt:.gt gtacc;agccc ttcctcacca 650
cctgcgacgg gcaccgggcc tgcagcac;ct accgaaccat ctataggacc 700
gcctaccgcc gcagccctgg gctggcc~.wa gccaggcctc gctacgcgtg 750
ctgccccggc tggaagagga ccagcgggct tcctggggcc t=gtggagcag 800
caatatgcca gccgccatgc cggaacggag ggagctgtgt c cagcctggc 850
395

CA 02421364 2003-03-25
cgctgccgct gccctgcagg atggc:ggggt gacacttgcc agtcagatgt 900
ggatgaatgc agtgctagga ggggcggctg tccccagcgc tgcatcaaca 950
ccgccggcag ttactggtgc cagtgttggg aggggcacag cctgtctgca 1000
gacggtacac tctgtgtc~cc caagcagaggg ccccccaggg tggcccccaa 1050
cccgacagga gtggacagtg caatgaagga ag aagtgcag aggctgcagt 1100
ccagggtgga cctgctggag gagaagctgc agctggtgct ggccccac:tg 1150
cacagcctgg cctcgcaggc actggagcat gggctc:ccgg accccggcag 1200
cctcctggtg cactccttcc agcagctcgg ccgcatcgac tccctgagcg 1250
agcagatttc cttcctggag gagcagctgg ggtcctgctc ctgcaagaaa 1300
gactcgtgac tgcccagcgc tcc:aggctgg a<a gagcccc tcacgccgcc 1350
ctgcagcccc catgcccctg cccaacatgc tgggggtcca gaagccac:ct 1900
cggggtgact gagcggaagg ccaggcaggg ccttc:ct:cct cttcctcctc 1950
cccttcctcg ggaggctccc cadaccctgg catgggatgg gctgggatct 1500
tctctgtgaa tccac:ccctg qct:ac~cccua ccctc~gc;tac cccaacggca 1550
tcccaaggcc aggtggaccc tcagctgagg gaaggtacga gctc:cctgct 1600
ggagcctggg acccatggca caggcdcacgc agcccggagg ctgggtgggg 1650
cctcogtggg ggctgctgcc tgacccccag cacaataaaa atgaaacgtg 1700
<210> 508
<211> 273
<212> PRT
<213> Homo sapiens
<900> 508
Met Arg Giy Ser Gln Glu 'Ja1 Leu Leu Met Trp Leu Leu Val Leu
1 5 =0 15
Ala Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val
~0 a5 30
Cys Ala Val Arg Ai.a His Gly App Pro Val Ser Glu Ser Phe Val
35 40 95
Gln Arg Val Tyr Gln Pro Phe LE~u Thr Thr Cys Asp Gi.y His Arg
50 55 60
Ala Cys Ser Thr Tyr Arg Thr I!e Tyr Arg Thr Ala Tyr Arg Arg
E.5 70 75
Ser Pro G1y Leu Ala Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro
80 85 90
Gly Trp Lys Arg Thr Ser e~ly Leu Pro Gly Ala Cys Gly Ala Ala
95 100 105
Ile Cys Gl.n Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro
110 715 120
346

CA 02421364 2003-03-25
Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln
125 130 135
Ser Asp Val Asp Glu c:ys Ser Ala Arg Arg C7ly G.ly Cys Pro Gln
140 195 150
Arg Cys Ile Asn Thr Ala C;ly Ser Ty:r Trp C:ys Gln Cys Trp Glu
155 160 165
Gly His Ser Leu Ser Ala Ash. Gly Thr Leu Cys Val Pro Lys Gly
170 175 180
Gly Pro Pro Arg Val Ala Fro Asn Pros Thr Gly Val Asp Ser Ala
185 190 195
Met. Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp Leu Leu
200 205 210
Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu Ala
215 220 225
Ser Gln Ala Leu Glu His C;ly Leu Pro Asp Prc Gly Ser Leu Leu
230 235 290
Val His Ser Phe Gln Gln Let. Gly Arg Ile Asp Ser Leu Ser Glu
29': 250 255
Gln lie Ser Phe Leu Glu ~~lu Gin Leu Gly Ser Cys Ser Cys Lys
260 265 270
Lys Asp Ser
<210> 509
<211> 1538
<21.2> I~NA
<213> Homo Sapiens
<400> 509
cccacgcgtc cgaagctggc cct.gcacggc tgcaagggag gctcctgtgg SO
acaggccagg caggtgggcc: tcaggaggtg cctcc:aggcg gccagtgggc 100
ctgaggcccc agcaagggct: agggtccatc tc:cagtccca ggacacagca 150
gcggccacca tggccacgcc tgggctccag cagcat~:.agc agcccccagg 200
accggggagg cacaggtggc ccccaccacc cggaggagca gctcctgccc 250
ctgtccgggg gatgactgat: tc':cctccgc c:aggccaccc agaggagaag 300
gccaccccgc ctggaggcac agc~ccatgag gggctctcag gaggtgctgc: 350
tgatgtggct tctggtgttg gcagtgggcg gcacagagca cgcctaccgg 400
cccggccgta gggtgtgtgc tgtccgggct c.acgdggacc ctgtctccga 950
gtcgttcgtg cagcgtgtgt accagccc.vt.t cctc<3ccacc t.gcgacgggc 500
accgggcctg cagcacctac cgaaccat.ct ataggaccgc c:taccgccgc 550
agccctgggc tggcccctgc caggcctc:gc tacgcgt:gct gccccggctg 600
39'i

CA 02421364 2003-03-25
gaagaggacc agcgggcttc: ctggggcct:g tggagcagca atatgccagc 650
cgccatgcc:g gaacggaggc~ agc:t:gtgt~,c agc:ctggccg ci=gccgctgc 700
cctgcaggat ggcggggtga cacttgccag t<:agatgtgg atgaatgcag 750
tgctaggagg ggcggctgtc; cccagcgctg cgt;caacacc g<:cggcagtt 800
actggtgcca gtgttgggag gggcacagcc tgtctgcaga cggtacactc 850
tgtgtgccca agggagggcc: ccccagggtg gc:ccccaacc cgacaggagt 900
ggacagtgca atgaaggaag aagtgcagag gct:gcagtcc agggtggacc 950
tgctggagga gaagctgcag ctc:gtgctgg ccccactgca cagcctggcc 1000
tcgcaggcac tggagcatgg gctcccgg:3c c;c<:ggcagc:c tcctggtgca 1050
ctccttccag cagctcggcc gcatc:gactc cctgagcgag cagatttcct 11.00
tcctggagga gcagctgggg tcctqctcct gcaagaaaga ctcgtgactg 1150
cccagcgccc caggctggao tgagc:ccct.c ac.gccgccct gcagccccca 1200
tgcccctgcc caacatgctg ggc;gt:ccaga agccacctcg gggtgactga 1250
gcggaaggcc aggcagggcc ttcctcctct tcctcctcc:c cttcctcggg 1300
aggctcccca gaccctggca tgr~g<~tgcgc t:gggatcttc tctgtgaatc 1350
cacccctggc tacccccacc ctqgctaccc caacggc:atc ccaaggc<;ag 1400
gtgggccctc agctgaggga aggtacgagc tc,cctgctgg agcctggqac 1950
ccatggcaca ggccaggcag cc<:ggaggct gggtggggcc tcactggggg 1500
ctgctgcctg acccccaqca caataaaaat gaaacqtq 1_'>38
<210> 510
<211> 273
<212> PRT
<213> Homo sapiens
<400> 510
Met Arg Gly Ser Gln Glu Val hEU Leu Met Trp heu Leu Val Leu
1 5 10 15
Ala Val Gly Gly Thr Glu His Ana Tyr Arg Pro Gly Arg Arg Val
20 25 30
Cys Ala Val Arg Ala His Gly Asp Fro Val Ser Glu Ser Phe Val
35 40 45
Gln Arg Val Tyr Gln Pro Phe Lea Thr Thr Cys Asp G1y His Arg
50 '.~5 6O
Ala Cys Ser Thr Tyr Arg Thr I.:e Tyr Arg Thr Ala Tyr Arg Arg
65 '/0 75
Ser Pro Gly Leu Ala Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro
80 85 90
348

CA 02421364 2003-03-25
Gly~ Trp hys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly Ala Ala
95 100 105
Ile Cys Gln Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro
110 115 120
Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln
125 1 ii) 135
Ser Asp Val Asp Glu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln
140 14.5 150
Arg Cys Val Asn Thr Ala Gl.y Ser Tyr Trp Cys Gln Cys Trp Glu
155 160 165
Gly His Ser Leu Ser Ala Asp Gly Thx Leu C:ys Val Pro Lys Gly
170 175 180
Gly Pro Pro Arg Val Ala Prc Asr: Prcs Thr Gly V<sl Asp Ser Ala
185 190 195
Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp Leu Leu
200 205 210
Glu Glu Lys Leu Gln i~eu Val Leu Ala Pro Leu His Ser Leu Ala
215 220 225
Ser Gln Ala Leu Glu Flis C~ly Lei: Prc; Asp Pro Gly Ser Leu Leu
230 23'_~ 290
Val His Ser Phe Gln Gln L,eu Gly Arg Ile Asp Ser Leu Ser Glu
295 250 255
Gln Ile Ser Phe Leu Glu C:lu Gln Leu Gly Ser Cys Ser Cys Lys
2 6C 265 270
Lys Asp Ser
<210> 511
<:211> 21
<:212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<.222> 1-21
<223> Artificial Sequence
<900> 511
tggagcagca atatgccagc c '21
<210> 512
<211> 22
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-22
<223> Artificial Sequence
<900> 512
349

CA 02421364 2003-03-25
ttttccact:c ctgtcgggtt gg a_'2
<210> 513
<211> 46
<212> DNA
<213> Artificial
<220>
<221> Artificial Sec~uenc:e
<222> 1-46
<223> Art.ific.ial Sequence
<400> 513
ggtgacactt gcc:agtcaga tgtggatgaa tgcagtgcta ggaggg 46
<210> 514
<211> 2690
<212> DNA
<213> Homo Sapiens
<220>
<221> unsure
<:222> 2039-2065
<223> unknown base
<400> 514
ggttgccaca gctggtttag gg<:cccgacc ac.tggggccc cttgtcagga 50
ggagacagcc tcccggcccg gggaggacaa gtcgctgcca cctttggctg 100
ccgacgtgat tccctgggac ggtccgtttc ctgccgtcag ctgccggc:cg 150
agttgggtct ccgtgtttca ggccggctcc cccttcctgg tctcccttct 200
cccgctgggc cggtttatcg ggaggagatt gtcttccagg gctagcaatt 250
ggactttt.ga tgatgtttga ccc:ag cggca ggaatagcag gcaacgtgat 300
ttcaaagctg ggctcagcct ctcitttcttc tctcgt:gtaa tcgcaaaacc 350
cattttggag caggaattcc aar.c<~tgtct cxtgatggtgg tgagaaagaa 900
ggtgacacgg aaatgggaga aac.:tccca;gg caggaac:acc ttttgctgtg 450
atggccgcgt catgatggcc cggcaaa<=gg gcatttt:cta cctgaccctt 500
ttcctcatcc tggggacatg tacactcttc ttcgcctttg agtgccgcta 550
cctggctgtt cagctgtctc ctgccatc-cc tgtatttgct. gccatgctct 600
tccttttctc catggctaca ctgttgac:ga cc:agcttcag tgaccctgga 650
gtgattcctc gggcgctacc agatgaagca gctttcatag aaatggagat 700
agaagctacc aatggtgcgg tgccccaggg ccagcgacca ccgcctcg to 750
tcaagaattt ccagataaac aaccagattg tgaaa ctgaa atactgttac 800
acatgcaaga t.cttccggcc t=ccccggcxc:c tcccattgca gcatctgtga 850
caactgtgtg gagcgcttcg ac::atcacvtg cccctgggtg gggaattgtg 900
ttggaaagag gaactaccgc tacttctacc tcttcatcct ttctctctcc 950
35u

CA 02421364 2003-03-25
ctcctcacaa tctatgtctt cgccttcaa~c atcgtctatg tggccctcaa 1000
atctttgaaa attggcttct tgqagacact gaaag.aaact cctggaactg 105C
tt.ctagaagt c:ctcatttgc ttctttacac tca.ggtccgt cgtgggactg 1100
actggat.tt:c atactttcct cgtggctct_c. aac.cagacaa ccaatgaaga 1150
catcaaagga tcatggacag ggaagaatcg cgtccagaat ccctacagcc 1200
atggcaatat tgtgaagaac tgctgtga:~g tgctgtgtgg ccccttgc.cc 125C
cccagtgtgc tggatcgaag gggtatttt:g cca ctggagg aaagtggaag 1300
tcgacctccc agtactcaag agaccagtag cagcctctt:g ccacagagcc 1350
cagcccccac agaacacctg aactc.aaar,g a<aatgccgga ggacagcagc 1900
actcccgaag agatgccacc tccagagccc ccagagccac cacaggaggc 1450
agctgaagct gagaagtagc ctatca atc~g aagagacttt tgtttgtgtt 1500
taattagggc tatgagagat ttcaggtgag aagttaaacc tgagacagag 1550
agcaagtaag ctgtcccttt taact:.gtttt tctttgqtc:t ttagtcaccc 1600
agttgcacac tggcattttc ttcctgcaag ct.tttttaaa tttctgaact 1650
caaggcagtg gcagaagatg tc<cgt:cacct ct:gataactg gaaaaatggg 1700
tctcttgggc cctggcactg gttct=ccot.g gcctcagcc:a cagggtcc:cc 1750
ttggaccccc tctcttccct cca=zgatccca qccctcctgc tt_ggggtcac 1800
tggtctcatt ctggggctaa aagtttttga gactggca ca aatcctcc:ca 1850
agctgctgca cgtgctgagt ccagaggcag tcacagagac ctctggccag 1900
gggatcc.taa ctgggttctt ggggtcttca ggact.gaaga ggagggac~ag 1950
tggggtcaga agattctcct ggccaccaag tgccagcatt gccc:acaaat 2000
ccttttagga atgggacagg taacttccac ttgttgtann nnnnnnnnnn 2050
nnnnnnnnnn nnnnnttgtt= ttTc~~ttt tg acacctgctc ccattaggag 2100
caggaatggc agtaataaaa gtat~3cactt tggtcat.tt:c tttt.cctcaa 2150
aggaagcccg agtgctcact taaacactat c-ccctcagac tccctgtgtg 2200
aggcctgcag aggccctgaa tgcacaaa:tg ggaaaccaag gcacagagag 2250
gctctcctct cctctcctct cccccgatqt accctcaaaa aaaaaaaaat 2300
gctaaccagt tcttccatta ag:~ctcggc:t gagtgaggga aagcccagca 2350
ctgctgccct ctcgggtaac tcaccctaag gcctcggccc acctctggct 2400
atggtaacca cactgggggc ttcctccaag ccccgct:ctt c:cagcacttc 2450
caccggcaga gtcccagagc cacttcac:cc tgggg gtggg ctgtggcccc 2500
351

CA 02421364 2003-03-25
cagtcagctc tgctcaggac ctg~otcta~.t tcagggaaga agatt=tatgt 2550
attatatgtg gctatatttc ctagagca::c tgtgtrttcc tca ttctaag 2600
ccagggtcct gtctggatga cttatgcgyt gggggagtgt aaaccggaac 2650
ttttcatcta tttgaaggcg attaaactyt. gt.ctaatgca 2f>90
<210> 515
<211> 364
<212> PRT
<213> Homo Sapiens
<400> 515
Met Ser Val Met Val Val Arg Lys hys Val Thr Arg Lys Trp Glu
1 5 10 15
Lys Leu Pro Gly Arg Asn Thr Phr: Cys Cys Asp Gly Arg Val Met
20 25 30
Met Ala Arg Gln Lys Gly Ile Phe 1'yr Leu Thr Leu Phe Leu Ile
35 40 95
Leu Gly Thr Cys Thr Leu Fhe Phe Ala Phe Glu Cys Arg Tyr Leu
50 55 60
Ala Val Gln Leu Ser Fre Ala Ile Pro Val Phe Ala Ala Met Leu
F>5 70 75
Phe Leu Phe Ser Met Ala Thr Lea Leu Arg Thr Ser Phe Ser Asp
80 85 gp
Pro Gly Val Ile Pro Arg Ala Leu Fro Asp Glu Ala Ala Phe Ile
95 100 105
Glu Met Glu Iie Glu Ala 'T'hz- Asn G'_y Ala V~~1 Pra Gln Gly Gln
110 115 120
Arg Pro Pro Pro Arg Ile Lys Asn Fhe Gln Ile Asn Asn Gln Ile
125 130 135
Val Lys Leu Lys Tyr C.ys 'yr Thr Cys Lys Ile Phe Arg Fro Pro
140 195 150
Arg Ala Ser His Cys Ser lle Cys Asp Asn Cys Val Glu Arg Phe
155 160 165
Asp His His Cys Pro Trp Va1 Gly Asn Cys Val Gly Lys Arg Asn
170 175 180
Tyr Arg Tyr Phe Tyr Leu I'he Ire Leu Ser Leu Ser Leu Leu Thr
185 190 195
Ile Tyr Val Phe Ala Phe Asn Ire Val Tyr Val Ala Leu Lys Ser
200 205 210
Leu Lys Ile Gly Phe Leu Glu Ttar Leu Lys Glu Thr Pro Gl.y Thr
215 220 225
Val Leu Glu Val Leu Ile t.'.ys Ptie Fhe Thr Leu Trp Ser Val Val
230 235 240
Gly Leu Thr Gly Phe His T'hr Pine Leu Val Ala Leu Asn Gln Thr
352

CA 02421364 2003-03-25
245 250 255
Thr Asn Glu Asp Ile Lys G;ly Ser Trp Thr Gly Lys Asn Ara_ Val
260 265 270
Gin Asn Pro Tyr Ser His G7.y Asa Ile Va.1 Lys Asn Cys Cys Glu
275 280 285
Val Leu Cys Gly Fro Leu Pro Pr:o Ser Val Leu Asp Arg Arg Gly
290 295 300
Ile Leu Pro Leu Glu Glu Ser Gl,~ Ser Arg Pro Pro Ser Thr Gln
305 310 315
Glu Thr Ser Ser Ser Leu Leu Pr:. Glr: Ser Pro Ala Pro Thr Glu
320 325 330
His Leu Asn Ser Asn Glu Met Pr~.> GLu Asp Ser Ser Thr Prr Glu
335 340 395
Giu Met Pro Fro Pro Glu Pro Pr~~ Glu Pro Pro Gln Glu Ala Ala
350 355 360
Glu Ala Glu Lys
<210> 516
<:211> 255
<212> DNA
<213> Homo Sapiens
<220>
<221> unsure
<'.222> 36, 38, 88, 118, 13'>, 193, 213, 222
<223> unknown base
<900> 516
aaaaccctgt attttttaca atgcaaatag acaatn<~ncc tggaggtctt 50
tgaattaggt attataggga tg<~tgggctt. gatttttntt cctggaggct 100
tttggctttg gactctcnct ttcac ccaca gagcnct:tcg accatcactg 150
cccctgggtg gggaattgtg ttc~gaaagag gaactaccgc tanttctacc 200
tcttcatcct ttntcactc<: cncctcaeaa tctatgtctt cgccatcaac: 250
atcgt 255
<210> 517
<217.> 24
<212> DNA
<213> Artificial
<220>
<227.> Artificial Sequence
<222> i-29
<223> Artificial Sequence
<900> 517
caacgtgatt tcaaagctgg gct.c 2,4
<210> 518
353

CA 02421364 2003-03-25
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 518
gcctcgtatc aagaatttcc 20
<210> 519
<211> 1F
<212> DNA
<213> Artificial
<:220>
<221> Artificial Sequence
<222> 1-1S
<223> Artificial Sequence
<400> 519
agtggaagtc gacctcc:c 18
<210> 520
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
c222> 1-29
<223> Artificial Sequence
<900> 520
ctcacctgaa atctctcata gcc.c 24
<210> 521
<:211> 50
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
~:222:> 1-50
<223> Artificial Sequence
<900> 521
cgcaaaaccc attttgggag caggaattcc aatcatgtct. gtgatggtgg 50
<210> 522
<211> 1679
<212> DNA
<213> Homo sapiens
<400> 522
gttgtgtcct tcagcaaaac agt.ggat~.ta aatctccttg c:acaagctt:g 50
agagcaacac aatctatcag gaaagaaaga aagaaaaaaa c:cgaacctga 100
caaaaaagaa gaaaaagaag aagaaaaaaa atcatgaaaa ccatccagcc 150
354

CA 02421364 2003-03-25
aaaaatgcac aattctatct cttgggcaat. cttca<~gggg ct.ggr_tgctc. 200
tgtgtctctt ccaaggagtg cccgtgcgc;a gcggagatgc caccttcccc 250
aaagctatgg acaacgtgac ggtccggcag ggggagagcg ccaccctcag 300
gtgcactatt gacaaccggg tcacccgggt ggcctggca a aaccgcagca 350
ccatcctcta tgctgggaat gacaagtggt gcctggatcc tcgcgtggtc 900
cttctgagca acacccaaac gcagtaca<7c at.cgagatcc agaacgtgga 950
tgtgtatgac gagggccctt acacctgcv.c ggt.gcagaca gacaaccacc 500
caaagacctc tagggtccac ctcattgt:lc aagtatctcc caaaattgta 550
gagatttctt cagatatctc cattaatgaa gggaacaata tr_agcctcac 600
ctgcatagca actggtagac cagagcctac ggttacttgg agacacatct 650
ctcccaaagc ggttggcttt gtgagtgaag acgaatactt ggaaattcag 700
ggcatcaccc gggagcagtc: aggggactac gagtgcagtg cctccaatga 750
cgtggccgcg cccgtggtac ggagagtaaa ggtcaccgtg aactatccac 800
catacatttc agaagccaag ggtacaggtg tccccgtggg acaaaagggg 850
acactgcagt gtgaagcctc agcagtcccc tcagcagaat tccagtggta 900
caaggatgac aaaagactga ttgaaggaaa gaaaggggtg aaagtggaaa 950
acagacctr_t cctctcaaaa ctcat=cttct tcaatgtct.c tgaacatgac 1000
tatgggaact acacttgcgt ggc.ctccaac aagctgggcc acaccaatgc 1050
cagcatcatg ctatttggtc caggcgccgt cagcgaggtg agcaacggca 1100
cgtcgaggag ggcaggctgc gtctggctgc tgcctcttct ggtcttgcac 1150
ctgcttctca aattttgatg tgagtgccac ttccccaccc gggaaaggct 1200
gccgccacca ccaccaccaa cacaacagca atggcaacac cgacagcaac 1250
caatcagata tatacaaatg aaattagaag aaacacagcc tcatgggaca 1300
gaaatttgag ggaggggaac aaagaatact ttggggggaa aagagtttto 1350
aaaaagaaat tgaaaattgc ctt~gcagata tttaggtaca atggagtttt 1400
cttttcccaa acgggaagaa cacagcacac ccggcatgga cccactgcaa 1450
gctgcatcgt gcaacctctt tggtgccagt gtgggcaagg gctcagcctc 1500
tctgcccaca gagtgccccc acgtggaaca ttctggagct ggccatccca 1550
aattcaatca gtccatagag acga.acactaa tgagaccttc cggcccaagc 1600
gtggcgctgc gggcactttg gtagactgtg ccaccacggc gtgtgttgtg 1650
aaacgtgaaa taaaaagagc aaaaaaaaa 1679
<210> 52~'
355

CA 02421364 2003-03-25
<211> 344
<212> PRT
<213> Home Sapiens
<4~~i> 5G3
Met Lys Thr Ile Gln Pro Lys Mei His Asn Ser Ile Ser 'i'rp Ala
15
Ile Phe Thr Gly Leu Ala Ala Leo Cys Leu E'he G1n (~ly 'Jal Pro
2C 25 30
Val Arg Ser Gly Asp Ala Thr Fhe F'ro Lys Ala Met Asp Asn Val
35 90 95
Thr Val Arg Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp
~; 0 5 .'; 6 0
Asn Arg Va1 Thr Arg Val Ala Trt:~ Leu Asn Arg Ser 'Chr Ile Leu
65 ;0 75
Tyr Ala Gly Asn Asp Lys Trp Cy:~ Leu Asp Pro Arg 'Jal Val Leu
80 85 90
Leu Ser F~sr. Thr Gln Thr Gln Tyr Ser Ile Glu Ile Gln Asn Val
95 100 105
Asp Val Tyr Asp Glu Gly Fro Tyr Thi: Cys Ser Val Gln Thr Asp
110 115 120
Asn His Pro Lys Thr Ser P.rg Val His Leu Ile Val Gl.n Val Ser
125 i3C 135
Pro Lys Ile Val G.lu Ile S~er Ser Asp Ile Ser Ile Asn Glu Gly
140 145 150
Asn Asn Ile Ser Leu Thr C~ys Ile Ala Thr Gly Arg Pro Glu Pro
155 160 165
Thr Val. Thr Trp Arg His Ile Ser Pro Lys Ala Val Gly Phe Val
170 175 180
Ser Glu Asp Glu Tyr Leu Clu Ile Gln Gly Ile Thr Arg Glu Gln
185 190 195
Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala Ala Pro
200 205 210
Val Val Arg Arg Val. Lys ''al Thr Val Asn Tyr Pro Pro Tyr Ile
215 220 225
Ser Glu Ala Lys Gly Thr (~ly Val Fro Val. Gly Gln Lys Gly Thr
230 235 290
Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp
245 250 255
Tyr Lys Asp Asp Ly~> Arg ,eu Ile G1u Gly Lys Lys Gl.y Val Lys
260 265 270
Val G.lu Asn Arg Pro Phe i~eu Se:r I_~ys Leu Ile Phe Phe Asn Val
275 280 285
Ser Glu His Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys
356

CA 02421364 2003-03-25
290 29'i 300
Leu G1y His Thr Asn A1a Ser Ile Met Leu Fhe Gly I'ro Giy Ala
3C5 310 315
Val Ser Glu Val Sez Asn GLy Thr Ser Arg Arg Ala C,~ly ~ys Val
320 32~~ 330
Trp Leu i~eu Pro Leu Leu Val Leu His Leu Leu Leu Lys Phe
335 39 C)
<2i0> '.i24
<211> 503
<212> DNA
<213> Homo sapiens
<400> 529
gaaaaaaaat catgaaaacc atccagccaa aaatgcacaa tt:ctatctct 50
tgggcaatct tcacggggct ggctgctcr_g tgtctcttcc aaggagtgcc 100
cgtgcgcagc ggagatgcca ccttccccaa agctatggac aacgtgacgg 150
tccggcaggg ggagagcgcc accctcaggt gcactattga caaccgggtc 200
acccgggtgg cctggctaaa ccgcagca~c at:cctctatg ctgggaatga 250
caagtggtgc ctggatcctc gcgtggtcct ~ctgagcaac: acccaaacgc 300
agtacagcat cgagatccag aacgtggatg tgtatgacga gggcccttac 350
acctgctcgg tgcagacaga caaccaccca aagacctcta gggtccac;ct 900
cattgtgcaa gtatctccca aaattgtaga gatttcttc,a gatatctcca 450
ttaatgaagg gaacaatatt agcctcacct gcatagcaac tggtagac:ca 500
gag 503
<:210> 525
<:211> 26C2
<212> DNA
<:213> Homo sapiens
<900> 525
atggctggtg acggcggggc cgggcagggg ac:cggggccg cggcccggga 50
gcgggccagc tgccgggagc ccr_gaatcac cgcctggccc gact.ccacca 100
tgaacgtcgc gctgcaggag ctgggagctg gcagcaacgt gggattccag 150
aaggggacaa gacagctgtt aggctcacgc acgcagctgg agctggtctt 200
agcaggtgcc tctctactgc tggctgca:ct g<.t.tctgggc t.gccttgtgg 250
ccctaggggt ccagtaccac agagacccat cccacagcac ctgccttaca 300
gaggcctgca ttcgagtggc tgg aaaaaztc ctggagtccc tggaccg,sgg 350
ggtgagcccc: tgtgaggact tttaccaqtt r_tcctgtggg ggctggattc 400
ggaggaaccc cctgcc:cgat ggg cgttc:tc gctggaacac cttcaacagc 450
357

CA 02421364 2003-03-25
ctctgggacc aaaaccaggc catactga~:g cacctgcttg aaaac:accac: 500
cttcaactcc aacagtgaag ctgagcagaa gacacagcgc ttctacctat 550
cttgcctaca ggtggagcgc att:4aggacxc tgggagcc:ca gccactgaga 600
gacctcattg agaagattgg tggttgga:cc attacggggc cctgggacca 650
ggacaactt.t atggaggtgt tgaaggcac~t agcagggacc tacagggcca 700
ccccattctt caccgtctac atcagtgca.-.g act.ct.aagag ttccaacagc 750
aatgttatcc aggtggacca gtctgggcrrc tttctgc:~ct ctcgggatta 800
ctacttaaac agaactgcca atgagaaa:yt gc:tcactgcc tatctggatt 850
acatggagga actggagatc~ ctgctgggtg qgcggcccac ctccacgagg 900
gagcagatgc agcaggtgct. ggagttggag atacagctgg ccaacatcac 950
agtgccccag gaccagcggc gcgacgagga gaagatctac cacaagatga 1000
gcattt.cgga gctgcaggc~. ctcgcgccca ccatggactg gcttgagttc 1050
ctgtctttc~t tgctgtcacc attggagttg agtgac:tctg agcctgtggt 1100
ggtgtatggg atggattatt:. tgcagcaggt gtcagagctc atcaaccqca 1150
cggaaccaag catcctgaac aattacct:ga tctggaacct ggtgcaaaag 1200
acaacctcaa gcctggaccg acc:ctttgag tc:tgcacaag agaagctact 1250
ggagaccctc tatggcacta agaagtcctg tgtgccgagg tggcagacct 1300
gcatctccaa cacggatgac gcccttggct rtgctttggg gtcactcttc 1350
gtgaaggcca cgtttgaccg gcaaagcaaa gaaatt<7cag aggggatgat. 1400
cagcgaaatc cggac:cc~cat ttctaggaggc: c-ctgggacag ctggtttgga 1450
tggatgagaa gacccgccag gcagccaagg agaaagc:aga tgcc:atctat 1500
gatatgattg gtttcccaga ct:ttatcctg gagcccaaag agctggatga 1550
tgtttatgac gggtacgaaa tt'ctgaaga ttctttcttc caaaacatgt 1600
tgaatttgta caacttctct gccaaggtta tggctgacca gctc;cgcaag 1650
cctcccagcc gagacc.agtg gagcatgacc ccccagacag tgaatgccta 1700
ctaccttcca actaagaatg ag,jtcgtc:tt ccccgct:ggc atc<agcagg 1750
cccccttcta tgcccgcaac ca:ccca<~gg ccctgaactt cggtggcatc 1800
ggtgtggtca tgggccatga gttgacgc:at gcctttgatg accaagggcg 1850
cgagtatgac aaagaaggga acctgcg<Icc ctgg2.ggcag aatgagtccc 1900
tggcagcctt ccggaaccac acggcctctca tggaggaaca gtacaat.caa 1950
taccaggt:.ca atggggagag gct:caacc~gc cgccagacgc tgggggagaa 2000
cattactgac aacggggggc tgaaggctgc: ctacaatgct tacaaagcat 2050
358

CA 02421364 2003-03-25
ggctgagaaa gcatggggag gag:ragcaac tgccagcc~gt ggggca cacc 2100
aaccaccagc tcttcttcgt ggg;~tttgcc c:ag gtgtggt gctcggtccg 2150
cacaccagag agctctcacg aggggctg<rt gaccgacc:cc cacagccctg 2200
cccgcttccg cgtgctgggc act;:tctcca actcccgtga cttcctgcgg 2250
cacttcggct gccctgtcgg ctcccccat.g aacccagggc agctgtgtga 2300
ggtgtggtag acctggatca ggggagaa~t ggccagctgt caccagacct 235C
ggggcagctc tcctgacaaa gctgtttgca cttgggttgg gaggaagcaa 2400
atgcaagctg ggctgggtct. agtccctcc:c ccccacaggt gacatgagta 2450
cagaccctcc tcaatcacca cattgtgc::t c_t:gctttggg ggtgcccctg 2500
cctccagcag agcccccac<~ attcactgtg acatctttcc gtgtcaccct 2550
gcctggaaga ggtctgggtg gggaggccag ttcccatagg aaggagtctg 2600
cc 2602
<210> 52 6
<211> 736
<212> PRT
<213> Homo sapiens
<400> 526
Met Asn Vai. Ala Leu Gln C,lu Leu Gly Ala Gly Ser Asn Val Gly
1 5 10 15
Phe Gln Lys Gly Thr Arg tln Leu Leu GIy Ser Arg Thr GLn Leu
20 % 5 30
Glu Leu Val Leu Ala Gly Ala Ser Leu Leu Leu ALa Ala Leu Leu
35 4(? 95
Leu Gly Cys Leu Val Ala :~eu Gly Val GLn Tyr His Arg Asp Pro
';0 55 60
Ser His Ser Thr C.'ys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly
65 70 75
Lys Ile Leu Glu Ser Leu .asp A_g Gly Val Ser Pro Cys Glu Asp
80 h5 90
Phe Tyr Gln Phe Ser Cys ,Gly G:iy Trp I:le Arg Arg Asn Pro Leu
95 100 105
Pro Asp Gly Arg Ser Arg Trp Asr: Thr Phe Asn Ser Leu Trp Asp
110 115 120
Gln Asn Gln A1a Ile Leu Lys His Leu LE:u Glu Asn Thr Thr Phe
125 130 135
Asn Ser Ser Ser c;lu Ala Glu GLn Lys Thr Gln Arg Phe 'ryr Leu
i90 195 150
Ser Cys Leu Gln Val Glu Arg Ile Glu Gl.u Leu Gly Ala Gln Pro
155 16C 165
359

CA 02421364 2003-03-25
Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly 'T'rp Asn Tle 'I'hr Gly
7 70 17~, 180
Pro Trp Asp Gln Asp Asn Pne Met Gl a Val Leu Lys Ala 'Jal Ala
185 19(~ 195
Gly Thr Tyr Arg Ala Thr Pro Ph<~ Phe Thr Val Tyr Ile Ser Ala
200 20r:~ 210
Asp Ser Lys Ser Ser Asn Ser Asn Val I'e Gln Va1 Asp Gln Ser
21F~ 220 225
G1y Leu Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala
230 235 240
Asn Glu Lys Val Leu Thr Al.a Tyr heu Asp Tyr Met Glu GLu Leu
295 250 255
Gly Met Leu Leu Gl.y Gly P.rg Pro Thr Ser Thr Arg Glu Gln Met
26G 265: 270
Gln Gln 'dal Leu Gl.u Leu Glu Ile Glr~ heu Ala Asn Ile Thr Val
275 280 285
Pro Gin Asp Gln Arg Arg Asp Glu Giu Lys Ile Tyr His Lys Met
290 295 300
Ser Ile Ser Glu Leu Gln Ala Leu Al.a Pro Ser Met Asp Trp Leu
3U5 310 315
Glu Phe Leu Ser Phe Leu Leu Ser Pro Leu Glu Leu Ser Rsp Ser
320 325 330
Glu Fro Val Val Val Tyr c~ly Met Asp Tyr Leu Gln Gln Val Ser
335 340 345
Glu Leu Ile Asn Arg Thr c:~lu Pro Ser Ile Leu Asn Asn Tyr Leu
350 355 360
Ile Trp Asn Leu Vai Gln Lys TOr Thr Ser Ser Leu Asp Arg Arg
365 3 7 0 375
Phe Glu Ser Ala C;ln Glu Lye Lc:;u Leu G'l.u Thr Leu Tyr Gly Thr
380 385 390
Lys Lys Ser Cys Val Pro Arg Trp Gln Thr Cys Ile Ser Asn Thr
395 900 905
Asp Asp Ala Leu Gly Phe Ala Le~u C;ly Ser Leu Phe Val. Lys Ala
410 915 920
Thr Phe Asp Arg c;ln Ser Lys Gl.u Ile Ala Glu Gly Met I1e 5er
925 430 435
Glu Ile Arg Thr Ala Phe Glu Giu Ala Leu Gly Gln Leu Val Trp
940 945 450
Met Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp Ala
955 960 965
Ile Tyr Asp Met Ile Gly Phe Fro Asp Fhe Ile Leu Glu Fro Lys
470 975 480
360

CA 02421364 2003-03-25
Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser
985 490 995
Phe Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys Val
50~~~
505 510
Met Ala Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser
515 520 525
Met Thr Pro Gln Thr Val Asn Ala Tyr Tyr Leu hro Thr hys Asn
530 535 590
Glu Ile Val Phe Pro Ala Gly Ile Leu Gln ~:la I'ro Phe Tyr Ala
54 5 550 555
Arg Asn His Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val
560 56_'~ 570
Met Gly His G1u Leu Thr H~s Ala Phe Asp Asp c';ln Gly Arg Glu
575 5so 585
Tyr Asp Lys Glu Gly Asn Leu Arc_; Pro Trp Trp Gln Asn Glu Ser
590 595 600
Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met G1u Glu Gln Tyr
605 610 615
Asn Gln Tyr Gln Val Asn Gly Glu Arg Leu Asn Gly Arg Gln Thr
620 625 630
Leu Gly Glu Asn Ile Thr Asp Asn G.ly Gly heu Lys Ala Ala Tyr
635: 640 695
Asn Ala Tyr Lys Ala Trp Leu Ar~a Lys His Gly Glu Glu Gln G1n
650 655 66C
Leu Prc Ala Val Gly Leu Thr Asri I-Iis Gln Leu Phe Phe Val Gly
665 670 675
Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser His
680 685 690
Glu Gly Leu Val Thr Asp fro His Ser Pro Ala Arg Phe Arg Val.
695 70G 705
Leu G1y Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly
7~~0 715 720
Cys Pro Vai Gly Ser Pro ~9et Asn Fro Gly Gln Leu Cys Glu Val
'725 7:0 735
Trp
<210> 527
<211> 9308
<212> DNA
<213> Homo sapiens
<220>
<221> unsure
<222> 1978, 3978, 905'7-4058, 9!"i70
361.

CA 02421364 2003-03-25
~223> unknown base
-4oe> 527
gcccggccct ccgccctccg cacvc~.:cgc:c tccctcc<ac cgcccgctcc 50
cgcgccotcc tccctc:c~~tc ctccccagc:t gtcccgttcg cgtcatgccg 100
agcctcccgg ccccgccg gc ccc~.~ctgctg c:tcctcgggc tgctgctgct 150
cggetcecgg ccggcecgcg geg~~cggee.c agagecce.ec gtgctgceca 200
tccgttctga gaaggagccg ctg~ccgttc ggggagcggc aggtaggtgg 250
gcgcccgggg gaggcgcggg cggggagtc;g ggctcggc~gc gagtcagcgc 300
cagcccggag ggggcgcggg gcgcaggtr~g c:tcggcgcgg cgggcggccc 350
ggagggtggg cgggggcaga agggcgcggt gcctgggacc cgggacccgc 400
gggcagccc;c cggggcggca cacggcgcc:3a gct:gggcagc ggcctccagc 450
caagcccgtc cccgcaggct gcaccttcrag cgggaaggtc tatgccttgg 500
acgagacgtg gcacccggac ctaggggac:c cattcggggt gatgcgctgc 550
gtgctgtgcg cctgcgaggc gcagtggggt cgccgtac;ca ggggccctgg 600
cagggtcaclc tgcaagaaca tcaaacca<~a gtgccc:aacc ccggcctgtg 650
ggcagccgcg ccagctgccg ggacoctgct gccagacctg cccccaggac 700
ttcgtggcgc tgctgac:agg gccgaggtcg caggcggtgg ca cgagcc:cg 750
agtctcgctg ctgcgct:cta gcctc:cgct:t ctctatctcc tacaggcggc 800
tggaccgccc taccaggatc cgcttctcag actccaatgg cagtgtcctg 850
t.ttgagcacc ctgcagcccc caccc;aagat ggcctggtct gtggggtgtg 900
gcgggcagtg cctcggttgt ctctgcggct ccttagggc:a gaacagct.gc 950
atgtggcact tgtgacactc act.caccctt caggggaggt ctgggggcct 1000
ctcatccggc accgggcc.ct gtc;cccaaag ac;cttcagtq ccatcctgac 1050
tctagaaggc ccccaccagc: agcXgcgtagg gggcatcac;c ctgctcactc 1100
tcagtgacac agaggac:tcc ttc7cattttt tgctgctctt ccgaggcc~tt 1150
gcaggactaa cccaggttcc: cttgaggotc cagattctac accaggggca 1200
gctactgcga gaacttcagg ccaatgt<:tc agcc<:aggaa ccaggctttg 1250
ctgaggtgct gcccaacctg acagtccagg agatggactg gctggtgctg 1300
ggggagctgc agatggccct ggagtggcaca ggcaggccaa ggctgcgcat 1350
cagtggacac attgctgcca ggaagagca g cgacgtc:ctg c:aaagtgtcc 1400
tttgtggggc taatgccctg at::ccagt.cc aaacgggtgc tgccggctca 1950
gccagcctca ctctgctagg aaatggcncc ctgat.cctcc aggtgcaatt 1500
362

CA 02421364 2003-03-25
ggtagggaca accagtgagg tggtggcc~;t gacactggaa accaagcctc 1550
agcggaggga tcagccca ct gtcca:gtgcc acatggctgg cctat:cctcc 1600
cctgccccca ggccgtgggt atctg~~cctg ggctggggtg cccgaggggc 1650
tcatatgctg ct.gcagaatg agctcttccvt gaacgtgqgc ac:caaggact. 1700
tcccagacgg agagcttcgg ggg;:,aacgt.g gctgccct,gc cctactgtgg 1750
ggcatagcgc ccgccctgcc cgtgcccc~a gcaggagccc tggtgctacc 1800
ccctgtgaag agccaagcag cagggcacc~c ctggcttt:cc tt;ggataccc 1850
actgtcacct gcactatgaa gtgctgctrag ctgggctt:.gg tggctcagaa 1900
caaggcact;g tcactgccca cct.ccttgc~g cct.cctggaa cgccagggcc 1950
tcggcggctg ctgaagggat tctatggctc agaggcccag ggtgtggtga 2000
aggacctgga gccggaactg ctgcggcac:c tggcaaaagg catggcttcc 2050
ctgatgatca ccaccaaggt agc.cccagag gggagctccg agggcagcct 2100
ctcctcccag gtgcacatag ccaaccaat:g tgaggttggc ggactgcocc 2150
tggagqcggc cggggcc:gag ggggtgcggg cgctgggggc t~..cggataca 2200
gcctctgctg cgccgcctgt ggtgcctggt c-tcccggccc tagcgcccgc 2250
caaacctggt ggtcctqggc ggc.cc:cgaga c:cccaacaca tgcttctt.cg 2300
aggggcagca gcgcccccac ggggctcgct gggcgcccaa ctacgacccg 2350
ctctgct.cac tctgcac:ctg ccagagacga ac:ggtgatct gtgacccggt 2900
ggtgtgccca ccgcccagct gcccacaccc ggtgc:aggct cccgaccagt 2950
gctgccctgt ttgccctggr_. tgcaattttg atggt.gaccg gagctggcgg 2500
gcagcgggta cgcggtggca ccc:cgttqtg crcccctttg gctt.aat,~_aa 2550
gtgtgctgtc: tgcacctgca agc:agggggg cactggagag gtgcactgtg 2600
agaaggtgca gtgtccccgg ctggcctgtg cccagcctgt gcgtgtcaac 2650
cccaccgact gctgcaaaca gtgtccaggt gagg<:ccacc c:ccagctggg 2700
ggaccccatg caggctgatg ggccccgggg ctgccgtttt gctgggcagt 2750
ggttcccaga gagtcagagc tggcaccc:ct cagtgccccc gtttggagag 2800
atgagctgta tcacct.gcag atqtgggqta agtgg ggagc agaggcttgt 2850
gtgaggtggg tactgggagc ctggtctgga gtagggagac cttcccaggg 2900
aggtccctga agaagctgaa ggtcactqt.g tccc,sgtgcc t=ctgggggac 2950
actcagtgtc tgctctgtct tgtaccaggc aggggtgcct cactgtgagc 3000
gggatgactg ttcactgcca ctgtcctgtg gctcggggaa ggagagtcga 3050
tgctgttccc gctgcacggc ccaccggc;g g cgtaagtgag ggagtccagg 3100
363

CA 02421364 2003-03-25
gtcagcagct gtgagtggag ggctcacctg cctgtgggac tcctgatcag 3150
agaagggagc actc:actgtg tgc«ggaaca gtgcagcctg c:ctcacaagt 3200
gccattccaa tccaccctca cagcaacctg gtggaattgt tatttatgac 3250
cttttcttt:a caaatgagat ttct:gaagct cagagaaatt: aagcaacgag 3300
atgaaggtca cccagctgtg tgcactgacc tgtttagaaa atactggcct 3350
ttctgggacc aaggcaggga tgcrtrgcc:c tgccct:c:t:at gc:ctctctgt 3900
gcctctccac tccctctccc ctcctccaac attccctccc ttctqtctc::c 3950
agcagcccca gagaccagaa ctg<itccaga gctggagaaa gaagccgaag 3500
gctcttaggg agcagccaga ggg~~caagig accaagagga tggggcctga 3550
gctggggaag gggtggcatc gaggaccttc ttgcattc~tc ct.gtgggaag 3600
cccagtgcct ttgctcctct gtcctgcc? c: tactcccacc cc:cactacct 3650
ctgggaacca cagctccaca agggggagag gcagctgggc cagaccgagg 3700
tcacagccac tccaagtcct gcc::t,gccac cctc:ggcctc tgtcctggaa 3750
gccccacccc tttcttcctg tacataatgt cactggcttg ttgggatttt. 3800
taatttatct tcactcagca ccaagggc ,c <:qgacact:cc actcctgctg 3850
cccctgagct gagcagagtc attattggag agttttgtat ttattaaaac 3900
atttctttit cagtctttgg gcatgaggtt ggctctttgt ggccaggaac 3950
ctgagtgggg cctggtggag aaggggcnga gagtaggagg tgagagagag 9000
gagctctgac acttggggag ctgaaagaga cctggagagg cagaggatag 4050
cgtggcnntt ggctggc:atn cctgggttcc gcagaggggc tggggatggt 4100
tcttgagatg gtctagagac tcaagaattt agggaagtag aagcaggatt 4150
ttgactcaag tttagtttcc cacatcgctg gc:ctgtttgc tgacttcatg 9200
tttgaagttg ctccagagag agaatcaaag gtgtcaccag cccctctc:tc 9250
cctccttccc ttcccti::ccc ttt.cl:ttc <;c t cccca<cr_.c t.cccctcc:cc 4300
tCCCCtCC 938
<210> 528
<211> 1285
<212> DNA
<213> Homo sapiens
<900> 528
ggccgagcgg gggtgctgcg cggcggcegt gatggctggt gacggcgggg 50
ccgggcaggg gaccggggcc gcggcccggg agcgggccag ctgccgggag 100
ccctgaat.ca ccgcctggcc cgactcca cc atgaacgtcg cgctgcagga 150
364

CA 02421364 2003-03-25
gctgggagct ggcagcaacg tgggattcca gaaggggaca agacagctgt. 200
taggctcacg cacgcagctg gagca ggtct tagcaggtgc ca ctctactg 250
ca ggctgcac tgcttctggg ctg<:ct:tgtg gccctagggg t:ccagtacca 300
cagagaccca tcccacagca cctqcctta~ agaggcctgc attcaagtgg 350
ctggaaaaat cctggagtcc ctggaccgag gggtgagccc ca gtgaggac 400
ttttaccagt tctcctgtgg gggcaggat t cggaggaacc <:cctgcccc~a 450
tgggcgttct cgctggaaca ccttcaaca.g cctctgggac raaaaccagg 500
ccatactgaa gcacctgctt. gaaaacacc-a crttc~aac-tc a:agcagtgaa 550
gctgagcaga agacacagcg cttctaccta tcttgcctac aggtggagcg 600
cattgaggag ctgggagccc agccactgag agacctcatt gagaagattg 650
gtggttggaa cattacgggg ccctgggac;c aggacaactt tatggaggtg 700
ttgaaggcag tagcagggac ctacagggcc accccatt:ct tcaccgtcta 750
catcagtgcc gactctaaga gttccaaca~g caatgttatc caggt:ggacc 800
agtctgggct ctttctgccc tct~gggat_t actacttaaa c<~gaactgcc 850
aatgagaaag taaggaacat. cttccgaac;c rc:catccc:t:a cccctggctg 900
agctgggctg atccctgttg acttttcc~a ttgccaaggg t~~agagcagg 950
gaaggtgagc ctatcctgtc: acctagtgaa caaactgccc ctcctttctt 1000
tCttCttttC ttCCtCCCtC: CCtCCCtttC t.tCCCCtttt CCttCCti.CC lOSO
ttcctcttat tcttctagta ggtr_tcatag acaccta~,tg tgtgccaggt 1100
ccagtggggg aattcggaga tataagtttc cgagccatt:g ccacaggaag 1150
cgttcagtgt cgatgggttc atagacctag ataggctgat aacaaagctc 1200
acaagagggt cctgaggatt caggagagac ttatggagcc agcaaagtct 1250
tcctgaagag attgcatttg agc:caggt~cc tgtag 1285
<210> 529
<211> 1380
<212> DNA
<213> Homo Sapiens
<:400> 529
atgcctacta ccttccaact aagaatgaga tcgtcttccc cgctggcatc 50
ctgcaggccc ccttctatgc ccgcaacc:ac cccaaggccc tgaacttcgg 100
tggcatcggt gtggtcatgg gccatgaqtt gacgcatgcc tttgatgacc 150
aagggcgcga gtatgacaaa gaagggaacc tgcggccctg gtggcagaat 20C
gagtccctgg cagccttccg gaaccacacg gcctgcatgg aggaacagt.a 250
caatcaatac caggtcaatg gggagagg ct caacggccgc cagacgctgg 300
365

CA 02421364 2003-03-25
gggagaacat: tgctgacaac ggggggctga aggctgccta caatgcttac 350
aaagcatggc tgagaaagca tggggaggag cagcaactgc c.~agccgtggg 400
gctcaccaac caccagctct tcttcgtggg at:t:tgcccag gtgtggtgct 450
cggtccgcac accagagagc tc:.tc;acgarg ggc:tggtgac c;gacccccac 500
agccctgccc gcttccgcgt gctclggcact ctctccaact c;ccgt.gactt 550
cctgcggcac ttcggctgcc ctqtcggct.c ccccatgaac ccagggcagc 600
tgtgtgaggt gt.ggtagacc tggatcag<.tg gagaaatggc cagctgtcac 650
cagacctggg gcagctctcc tgacaaagc;t gtttgctctt gggtt:gggag 700
gaagcaaatg caagctgggc tgggtctactt cc.-ctcccccc cacaclgtgac 750
atgagtacag accctcctca atc,accac,t tgt.grct~:tg ctttgggggt 800
gcccctgcct ccagcagagc ccccaccar.t cac;tgtgaca tctttccgtg 850
tcaccctgc:c tggaagaggt ctgggtggc~g aggccagttc ccataggoag 900
gagtctgcct cttctgt.ccc caggctca.,t cagcctggcg g~~catggggc 950
ctgccgtgcc tgccccactg tg<:cccacag gcctgggtgg tgtacctc:ct 1000
ggacttctcc ccaggctcac tca.~gt:gcgca <;ttaggggtg gactcagc;tc 1050
tgtctggctc accctc<3cgg gct.accccca c;ctcaccctg tgctcctt:gt 1100
gccactgctc ccagtgc:tgc tgctgacctt cactgac:agc tcctagtqga 1150
agcccaaggg cctctgaaag cctcctgctg cccactgttt ccctgggc.tg 1200
agaggggaag tgcatatgtg tagcgggtac tggttcctgt gtcttagggc 1250
acaagcctta gcaaatgatt gattctcc:ct. ggacaaagca ggaaagcaga 1300
tagagcaggg aaaaggaaga ac.~gagttta tttttacaga aaaqagggtg 1350
ggagggtqtg gtcttggccc ttataggacc 1380
<210> 530
<211> 39
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-39
<223> Artificial Sequence
<400> 530
gaagcagtgc agccagcagt agagaggcac ctgctaaga 39
<210> 531
<211> 24
<212> DNA
<213> Artificial
366

CA 02421364 2003-03-25
<220>
<221> Arti.fic.ial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 531
acgcagctgg agctggtctt agca 24
<210> 532
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<400> 532
ggt.actggac ccctagggcc acaa 29
<210> 533
<211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21
<223> Artificial Sequence
<900> 533
cctcccagcc gagaccagtg g 71
<210> 539
<21i> 21
<212> DNA
<213> Artificial
<220>
~:221> Artificial Sequence
<222> 1-21
<223> Artificial Sequence
<900> 534
ggtcctataa gggccaagac c a1
<210> 535
<211> 44
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-99
<223> Art-ificial Sequence
<900> 535
gactagttct agatcgcgag cggccgccct tttttttttt tttt 49
<210> 536
<211> 16
<212> DNA
367

CA 02421364 2003-03-25
<213> Artificial
<220>


<221>Artificial Sequence


<222>1-16


<223>Artificial Sequence


<400>536


cggacgcgtg
ggtcga
16


<210>53'1


<211>21


<212>DNA


<213>Artificial


<220>


<221>Artificial Sequence


<222>1-21


<223>Artificial Sequence


<900>53i


cggccgtgat
ggctggtgac
g
2.i


<210>538


<211>20


<212>DNA


<213>Artificial


<220>


<-221>Artificial Sequence


<:222>1-20


<223>Artificial Sequence


<400>538


ggcagactcc
ttcctatggg
20



368

CA 02421364 2003-03-25
DE1~IANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEyLaNDE OU CE BREVETS
CO~IPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE~
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
THIS IS VOLUME OF
NOTE: For additional volumes please contact the Canadian Patent Office.