NOVEL POYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME

NOUVEAUX POLYPEPTIDES ET ACIDES NUCLEIQUES LES CODANT

English Abstract

The present invention is directed to novel polypeptides and to nucleic acid
molecules encoding
those polypeptides. Also provided herein are vectors and host cells comprising
those nucleic acid
sequences, chimeric polypeptide molecules comprising the polypeptides of the
present invention
fused to heterologous polypeptide sequences, antibodies which bind to the
polypeptides of the
present invention and to methods for producing the polypeptides of the present
invention.

Claims

WHAT IS CLAIMED IS:
1. Isolated nucleic acid having at least 80% sequence identity to a nucleotide
sequence that encodes a polypeptide comprising the amino acid sequence shown
in Figure 196
(SEQ ID NO:468).
2. The nucleic acid of Claim 1, wherein said nucleotide sequence comprises the
nucleotide sequence shown in Figure 195 (SEQ ID NO:467).
3. The nucleic acid of Claim 1 or Claim 2, wherein said nucleotide sequence
comprises the full-length coding sequence from within the sequence shown in
Figure 195 (SEQ
ID NO:467).
4. The nucleic acid of Claim 1 which comprises the full-length coding sequence
of
the DNA deposited under accession number ATCC 209865.
5. Isolated nucleic acid having a nucleotide sequence that encodes a
polypeptide
comprising the amino acid sequence shown in Figure 196 (SEQ ID NO:468).
6. The nucleic acid of Claim 5, wherein said nucleotide sequence comprises the
nucleotide sequence shown in Figure 195 (SEQ ID NO:467).
7. The nucleic acid of Claim 5 or Claim 6, wherein said nucleotide sequence
comprises the full-length coding sequence from within the sequence shown in
Figure 195 (SEQ
ID NO:467).
8. The nucleic acid of Claim 5 which comprises the full-length coding sequence
of
the DNA deposited under accession number ATCC 209865.
9. A vector connprising the nucleic acid of any one of claims Claim 1 to 8.
10. The vector of Claim 9 wherein said nucleic acid is operably linked to
control
sequences recognized by a host cell transformed with the vector.
11. A host cell comprising the vector of Claim 9 or Claim 10.
12 The host cell of Claim 11 wherein said cell is a CHO cell, an E. toll or a
yeast
cell.
13. A process for producing a polypeptide comprising culturing the host cell
of Claim
11 or Claim 12 under conditions suitable for expression of said polypeptide
and recovering said
polypeptide from the cell culture.
14. Isolated polypeptide comprising a sequence having at least 80% sequence
identity


to the amino acid sequence shown in Figure 196 (SEQ ID NO:468).
15. Isolated polypeptide comprising a sequence having at least 80% sequence
identity
to the amino acid sequence encoded by the nucleotide deposited under accession
number ATCC
209865.
1 (i. Isolated polypeptide comprising a sequence having the amino acid
sequence
shown in Figure 196 (SEQ ID NO:468).
17. Isolated polypeptide comprising a sequence having the amino acid sequence
encoded by the nucleotide deposited under accession number ATCC 209865.
18. A chimeric molecule comprising a polypeptide according to any one of
Claims 14
to 17, fused to a heterologous amino acid sequence.
19. The chimeric molecule of Claim 18 wherein said heterologous amino acid
sequence is an epitope tag sequence.
20. The chimeric molecule of Claim 18 wherein said heterologous amino acid
sequence is a Fc region of an immunoglobulin.
21. An antibody which specifically binds to a polypeptide according to any one
of
Claims 14 to 17.
22. The antibody of Claim 21 wherein said antibody is a humanised antibody.
23. The antibody of Claim 21 wherein said antibody is a monoclonal antibody.
24. The antibody of Claim 23 wherein said antibody is a chimeric antibody.
25 A composition comprising an antibody according to any one of Claims 21 to
24
inadmixture with a pharmaceutically acceptable carrier.

Description

CA 02421388 2003-03-25
DE1~IANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DE1'I_.~i~IDE OU CE BREVETS
CO!~iPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE~
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION i PATENT CONTAINS WORE
THAN ONE VOLL VIE.
THIS IS VOLUItE~ OF
NOTE: For additional volumes please contact the Canadian Patent Office.

CA 02421388 2003-03-25
230 235 290
His Phe Leu Ala Leu Asp Ala Se.r Gln His SE:r Ser Leu Ser Thr
245 a50 255
Arg Phe Gly Thr Val Ala Val Pro A~;n Ile Leu Leu Phe Gln G1y
260 265 270
Ala Lys Pro Met Ala Arg Phe Asn His Thr Asp Arg Thr heu Glu
275 280 285
Thr Leu Lys I.le Phe Ile Phe Asn G1n 'I'hr Gly Ile Glu Ala Lys
290 295 300
Lys Asn Val Val Val Thr Gln A1a P.sp Gln Ile Gly Pro Leu Pro
305 310 315
Ser Thr Leu Ile Lys Ser Val Asp Trp Leu heu Val Phe Ser Leu
320 325 330
Phe Phe Leu L1e Ser Phe Ile Met 'I'yr Ala 'Chr Ile Arg Thr Glu
335 340 345
Ser Ile Arg Trp Leu Ile Pro Gly ~~ln Glu Gln Glu His Val Glu
350 3'_~5 360
<210> 411
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<:400> 411
cacagagcca gaagtggcgg aatc 24
<210> 412
<'211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial Sequence
<400> 412
ccacatgttc ctgct<atgt cctgg 25
<210> 413
<211> 45
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-45
<223> Artificial Sequence
<400> 913
267.

CA 02421388 2003-03-25
cggtagtgac tgtactctag tcctgtttta cvacc:ccgtgg tgccg 45
<210> 414
<211> 1196
<212> DNA
<213> Homo Sapiens
<400> 419
cccggctccg ctccctctgc cccctcgggg tcgcgc:gccc acgatgctgc 50
agggccctgg ctcgctgctg ctgctcatcc tcgccr_cgca ctgctgcctg 100
ggctcggcgc gcgggctctt cctctt:tggc cagcccg~.ct tct:cctacaa 1.50
gcgcagcaat tgcaagccca tcccggtcaa cctgcagctg tgccacggca 200
tcgaatacca gaacatgcgg ca gcccaacc tgctgggcca cgagaccatg 250
aaggaggtgc tggagcaggc cggcgcttgg atc:c:cgctgg tcatgaagco 300
gtgccacccg gacaccaaga agttcctgtg ctcgctcttc gcccccgtct 350
gcctcgatga cctagacgag accatccagc catgccactc gca ctgcgtg 900
caggtgaagg accgctgcgc cccgcltcatq tccg~~cttcg gcttcccctg 450
gcccgacatg cttgagtgcg accgtttccc: ccaggacaac gacctttgca 500
tccccctcgc tagcagcgac cacctcctgc; cagccac~cga ggaagctcca 550
aaggtatgtg aagcctgcaa aaataaaaat gatgatgaca acgacataat 600
ggaaacgctt tgtaaaaatg attttgcact gaaaataaaa gtgaaggaga 650
taacctacat caaccgagat accaaaatca tcctggagac caagagcaag 700
accatttaca agctgaacgg tgtgtccgaa agggacctga agaaatcggt 750
gctgtggctc aaagacagct tgcagtgcrac ctgtgaggag atgaacgaca 800
tcaacgcgcc ctatctggtc: atgggacaga aac;agggtgg ggagctggtg 850
atcacctcgg tgaagcggtg gcagaaggylg cagag,sgagt tcaagcgcat 900
ctcccgcagc atccgcaagc tgcagtgcta gtc:ccggcat cctgatggct 950
ccgacaggcc tgctccagag cac;ggctgac cat:ttctgct ccgggatc;tc 1000
agctcccgtt ccccaagcac aci:cctagct. gc:tcc.agtct. cagcctgggc 1050
agcttccccc tgccttttgc acgtttgc;at cr_ccagcatt. tcctgagtta 1100
taaggccaca ggagtggata gctgttttca cctaaaggaa aagcccaccc 1150
gaatcttgta gaaatattc:a aactaataaa atca~gaata ttttaa 1196
<210> 415
<21.1> 295
<212> PRT
<213> Homo Sapiens
<900> 415
Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser
2 c~ 2

CA 02421388 2003-03-25
1 5 10 15
His Cys Cys Leu Gly Ser Ala Arg G:iy Leu Phe Leu Phe Gly Gln
20 25 30
Pro Asp Phe Ser Tyr Lys Arg Ser Asn Cy~s Lys Pro Ile Pro Val
35 40 45
Asn Leu Gln Leu Cy~. His Gly Ile Glu Tyr Gln Asn Met Arg Leu
50 55 60
Pro Asn Leu Leu Gly His Glu Thr Met Lys C~lu Vai Le~.a Glu Gin
65 '70 75
Ala Gly Ala Trp Ile Pro Leu Val Met: Lys c:~ln Cys His Pro Asp
80 85 90
Thr Lys Lys Fhe Leu Cys Ser heu I?he Ala Fro Val Cys Leu Asp
95 100 105
Asp Leu Asp Glu Thr Ile Glr: Pro Cys His Ser Leu Cys Val Gln
110 1:15 120
Val Lys Asp Arg Cys Ala Pro 'Jal Met Ser Ala Phe G1y Phe Pro
125 130 I35
Trp Pro Asp Met Leu Gl.u Cys Asp Arg Phe Pro Gln Asp Asn Asp
140 145 150
Leu Cys Ile Pro Leu A:La Ser Ser Asp His Leu Leu Pro F.la Thr
155 160 165
Glu Glu Ala Pro Lys Val Cys Glu Ala Cys Lys Asn Lys Asn Asp
170 175 180
Asp Asp Asn Asp Ile Met Giu Thr Leu ~Cya Lys Asn Asp Phe Ala
185 190 195
Leu Lys Ile Lys Val hys Glu IlcThr Ty° Ile Asn Arg Asp Thr
200 20'~ 210
Lys Ile Ile Leu Glu 'Chr Lys See Lys Thr Ile Tyr Lys Leu Asn
215 220 225
Gly Val Ser G.lu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys
2.30 235 240
Asp Ser Leu Gln Cys Thr Cys Glu Glu Met Asn Asp Il.e Asn Ala
295 250 255
Pro Tyr Leu Val Met Gly t~ln Lys C~ln Gl.y Gly Glu Leu Val Ile
260 255 270
Thr Ser Val Lys Arg Trp Gln Lys Gly Gln Arg Glu Phe Lys Arg
275 280 285
Ile Ser Arg Ser Ile Arg Lys Leu Gln Cys
290 295
<210> 416
<211> 21
<212> DNA
<213> Artificial
263

CA 02421388 2003-03-25
<220>
<221> Artificial Sequence
<222> 1-21
<223> Artificial Sequence
<400> 416
cctggctcgc tgctgctgct c 21
<210> 417
<211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial Sequence
<400> 91.
cctcacaggt gcactgcaag ctgtc ''<:5
<2i0> 418
<211> 4.
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<:222> 1-47
<223> Artificial Sequence
<400> 41S
ctcttcctct ttggccagcc cgacttctcc tacaaccgca gaatt.gc 47
<210> 419
<211> 1830
<212> DNA
<213> Homo Sapiens
<400> 919
gtggaggccg ccgacgatgg cggggccgac ggaggccgag acggggttgg 50
ccgagccccg ggccctgtgc gcac<~gcggg gccaccgcac ctacgcgcgc 100
cgctgggtgt tcctgctcgc gatcagcctg ctcaactgct ccaacgccac 150
gctgtggctc agctttgcac ctgtggctga cgtcattgct gaggacttgg 200
tcctgtccat ggagcagat:c aactggctgt cactggtcta cctcgtggta 250
tccaccccat ttggcgtggc ggccatctgg atcctggact ccgtcgggct 300
ccgtgcggcg accatcctgg gtgcgtggct gaactttgcc gggagtgtgc 350
tacgcatggt gccctgcatg gttgttggga cccaaaaccc: atttgccttc 400
ctcatgggtg gccagagcct ctgtgccct.t gccc:agagcc. tggtcatctt 450
ctctccagcc: aagctggctg c<~ttgtggtt cccagagcac: cagcgagcca 500
cggccaacat gctcgccacc atgtcgaacc ctctgggcgt ccttgtggcc 550
264

CA 02421388 2003-03-25
aatgtgctgt cccctgtgct ggtcaagaag ggtgaggaca ttc~ugttaat 600
gctcggtgtc tataccatcc ctgctggcgt ;:gtctgcctg ctgtccacca 650
tctgcctgtg ggagagtgtg ccccccaccc ~gccca:ctgc cggggctgcc 700
agctccacct cagagaagtt cctagcatggg ct:caa<~ctgc agcacatgtg 750
gaacaaggcc tatgt.catcc tggctgtgtg cttggggclga at<~atcggga 800
tctctgccag cttctcagcc: ctcctggagc agatcctca g tgcaagcggc 850
cactccagtg ggttttccgg cctctgtggc gct<:tcti~ca tcacgtt_tgg 900
gatcctgggg gcactggctc tcggccccta tgtgGac::gg accaagcact 950
tcactgaggc caccaagatt ggcctgtgcc tgttca ct.ct ggcctgcgtg 1000
ccctttgccc tggtgtccca gctgcaggga cagac ccttg ccctggctgc 1050
cacctgctcg ctgctcgggc tgttt.ggctt ctcggtgggc cccgtggcca 1100
tggagttggc ggtcgagtgt tccttccccc; tggggg<iggg ggctgccaca 1150
ggcatgatct ttgtgctggg gcaggccgacggaatactca tcatgctggc 1200
aatgacggca ctgactgtgc gacgctcgga gccgtc~ttg tccacctgcc 1250
agcaggggga ggatccactt gactggacag tgtca ctgct gctgatggcc 1300
ggcctgtgca ccttcttcag ctgcat:cctg gcggtcttct tccac:acc<:c 1350
ataccggcgc ctgcaggccg agtcagggga gc.~.cccctcc acccgtaacg 1900
ccgtgggcgg cgcagactca gggccgggtg tggaccgagg gggagcagga 1450
agggctgggg tcctggggcc cag cacggc;g act.ccc~gagt gcacggcgag 1500
gggggcctcg ctagaggacc: ccagaggg.:c cgggagcccc cacccagcct 1550
gccaccgagc gactccccgt gcgcaaggcc cagcagccac cgacgcgccc 1600
tcccgccccg gcagactcgc aggcagggtc ca<3gcgtcca ggtttatt.ga 1650
cccggctggg tctcactcct cct:tctcctc cc~~gtgggtg atcacgtagc 1700
tgagcgcctt gtagtccagg ttgc~~cgcca catcgatgga ggcgaactgg 1750
aacatctggt ccacctgcgg gcgggggcga aaggg ctcct tgcgggctc:c 1800
gggagcgaat tacaagcgcg cacctgaaaa 1830
<210> 420
<211> 560
<212> PRT
<213> Homo Sapiens
<400> 420
Met Ala Gly Pro Thr Glu A1a C~lu Thr Gly Leu Ala Glu Pro Arg
7. ' 10 15
Ala Leu Cys Ala Gln Arg Gly Isis Arg 'lhr Tyr Ala Arg Arg Trp
20 25 30
265

CA 02421388 2003-03-25
Val Phe Leu Leu Ala Ile Ser Leu Lc=u Asn Cys Ser Asn Ala Thr
35 4C 45
Leu Trp Leu Ser Phe Ala Pro Val Ala Asp Val I1e Ala Glu Asp
50 55 60
Leu Val Leu Ser Met Glu Gln Ile Asn Trp heu Ser Leu Val Tyr
n;j 75
Leu Val Val Ser Thr Pro Phe Gly Val Ala Ala Ile Trp Ile Leu
80 85 90
Asp Ser Val Gly Leu Arc, Ala Ala '"hr Ile Leu Gly Aia Trp Leu
95 100 105
Asn Phe Ala Gly Ser Va1 Leu Arg Met Val Pro Cys Met. Val Val
11U 1~5 120
Gly Thr Gln Asn Pro Phe Ala Phe Leu Met Gly Gl.y Gln Ser Leu
125 130 135
Cys Aia Leu Ala Gln Ser Le.a Val Ile Phe Ser Pro Ala Lys Leu
1.10 i45 150
Ala Ala Leu Trp Phe Pro Glu His Gln Arg Ala Thr Ala Asn Met
155 i60 165
Leu Ala Thr Met 5er Asn Pro Leu Gly Val Leu Val Ala Asn Val
170 X75 180
Leu Ser Pro Val Leu Val Lys Lys Gly Glu Asp 1:1e Pro L~eu Met
'.85 190 195
Leu Gly Val Tyr 'I'hr Lle Pro Ala Gly Va:. Val Cys Leu Leu Ser
200 205 210
Thr Ile Cys Leu Trp Glu Ser Val Pro Pry Thr Pro Pro Ser Ala
215 220 225
Gly Ala Ala Ser Ser Thr Ser Glu Lys Phe Leu Asp Gly Leu Lys
230 235 240
Leu Gln Leu Met Trp Asn Lys Ala Tyr Val I:Le Leu Ala Val Cys
295 250 255
Leu Gly Gly Met Ile Gly Ile SE~r A1a Ser Phe Ser Ala Leu Leu
260 265 270
Glu Gln Ila Leu Cys Ala Ser G1y His Ser Ser Gly Phe Ser Gly
275 280 285
Leu Cys G1y Ala Leu Phe Il.e Thr Phe Gly Ile Leu Gly Ala Leu
290 295 300
Ala Leu Gly Pro Tyr Val Asp Arg Thr hys His Phe Thr Glu Ala
305 310 315
Thr Lys Ile Gly Leu Cys Leu Phe Ser :~eu A1a Cys Val Pro Phe
32(i 325 330
Ala Leu Val Ser Gln Leu Gln Gly Gln Thr Leu Ala Leu Ala Ala
335 390 395
266

CA 02421388 2003-03-25
Thr Cys Ser Leu I:eu Gly Leu Phe G.'_y F?he Ser Val Gly Pro Val
350 35': 360
Ala Met Glu Leu Ala Val Glu Cys Sur Phe: Pro Val Gly Glu c,ly
365 370 3-75
Ala Ala Thr Gly Met I1e Phe Val Leu Gly G1n Ala Glu Gly Ile
380 385 390
Leu Tle Met. Leu Ala Met Thr Ala I..eu Thr Val Arg Arg Ser Glu
395 900 405
Fro Ser Leu Ser Thr Cys Gln Gln Gly Glu asp Pro Leu Asp Trp
910 915 420
Thr Val Ser Leu Leu Leu Met Ala Gly Leu Cys Thr Phe PY.e Ser
425 430 435
Cys Ile Leu Ala Val Phe Phe fiis Thr Pro Tyr Arg Arg Leu Gln
440 945 450
Ala Glu Ser Gly Glu Pro Pro Ser Thr Arg Asn Ala Val Gly Gly
955 460 465
AIa Asp Ser Gly Pro Gly Val Asp Arg Gly Giy Ala G1y Arg Ala
470 475 480
Gly Val Leu Gly Pro Ser Thr Ala Thr Pro Glu Cys Thr Ala Arg
985 490 495
Gly Ala Ser Leu Glu Asp Pro Ara Gly Pro Gly Ser Fro His Pro
50C 505 510
Ala Cys His Arg Ala Thr Pro Arc, Ala Glr: Gly Pro Ala Ala Thr
515 520 525
Asp Ala Pro Ser Arg Pro Gly Arg 'Leu Al,a Gly Arg Val Gln Ala
530 535 540
Ser Arg Phe Ile Asp Pro F,la Gly Ser His Ser Ser Phe Ser Ser
545 550 555
Pro Trp Val Ile Thr
560
<210> 421
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<22.3> Artificial Sequence
<400> 421
agcttctcag ccctcctgga gc:ag 2~1
<210> 422
<211> 25
<212> DNA
<213> Artificial
a: 6 7

CA 02421388 2003-03-25
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial. Sequence
<400> 422
cgggtcaata aacctggacg cttgg 2'>
<210> 423
<211> 93
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-43
<223> Artificial Sequence
<400> 423
tatgtggacc ggaccaagca cttcactgaq gccaccaaga ttg 43
<210> 429
<21i> 4313
<212> DNA
<213> Homo Sapiens
<400> 429
gtcccacatc ctgctcaact gggt.caggtc cctcttagac cagctcttgt 50
ccatcatttg ctgaagtgga ccaac~agtt ccccaqtagg <~ggtctcccc 100
tggcaattct tgatcggcgt ttggacatca cagatc:gctt_ ccaatgaaga 150
tggccttgcc ttggggtcct gcttgttt~:a taatc.3tcta actatgggac 200
aaggttgtgc cggcagctct gggggaagga gcacggggct gatcaagcca 250
tccaggaaac actggaggac ttgtccagcc tt:gaaagaac tctagtggtt 300
tctgaatcta gcccacttgg cggtaagcat gatgcaactt ctgcaacttc 350
tgctggggct. tttggggcca ggtggctact tattt:ctttt aggggattgt 900
caggaggtga ccactctcac ggtgaaatac caagrgtcag aggaagtgcc 450
atctggtaca gtgatcggga agctgtc~~ca ggaactgggc cgggaggaga 500
ggcggaggca agctggggcc: gc.cttccagg tc~ttgcagct gcctcaggcg 550
ctccccattc aggtggactc tcxaggaaggc ttgca cagca caggcaggcg 600
gctggatcga gagcaqctgt gccgacagtg ggat:ccctgc ct.ggtttcct 650
ttgatgtgct tgccacaggg gatttgctctc tga~_ccatgt ggagatccaa 700
gtgctggaca tcaatgacca ccagccacgg t.tt::ccaaag gcgagcagga 750
gctggaaatc tctgagagcg cct.ctctgcg aacccggatc cccctggaca 800
gagctcttga cccagacaca ggccctaaca ccc.tgcacac ctacactctg 850
tctcccagtg agcactttgc cttggatgtc att:gtgggcc ctgatgagac 900
268

CA 02421388 2003-03-25
caaacatgca gaactcatag tggtgaagga gctggacagg gaaatccatt 950
cattttttga tctggtgtta actgcctatg acaatgggaa cccccccaag 1000
t;~aggtacca gcttggtcaa ggtcaacgtc ttggactcca atgacaatag 1050
ccctgcgttt gctgagagtt cactggcact ggaaatccaa gaagatgctg 1100
cacctggtac gcttctc<~ta aaactc3a~~cg ccacagaccc tgaccaaggc 1150
cccaatgggg aggtggagtt catcctcagt aagcaca:gc ctccagaggt 1200
gctggacacc ttcagtattg atgccaagac aggcc:aggtc attctgcgtc 1250
gacctctaga ctatgaaaag aaccctgcct acgac3gtgga tgttcaggca 1300
agggacctgg gtcccaatcc tatcc;cagcc cattgcaaag ttctcatca<~ 1350
ggttctggat gt.caatgaca acatcccaag catccacgtc acatgggc:ct 1400
cccagccatc actggtgtca gaagctcttc: ccaaggacag ttttattgct 7.450
cttgtcatgg cagatgactt ggattcagga caca.atggtt tggtccactg 1500
ctggctgagc caagagctgg gccacttcag gctgaaaaga actaatgg<:a 1550
acacatacat gttgctaacc aatgcc:acac tggacagaga crcagtggccc 1600
aaatataccc tcactctgtt agcr:caagac caaggactcc agccctta~c 1650
agccaagaaa cagctcagcs ttcagatcag tgacat:caac gacaatgcac: 1700
ctgtgtttga gaaaagcagg tatgaagtct ccacgcggga aaacaactta 1750
ccctctcttc acctcattac~ catcaaggc t catgatgcag acttgggc:at 1800
taatggaaaa gtctcatacc gcatc;cagga ctccccagtt gctcactt.ag 1850
tagctattga ctccaacaca ggag<aggtca ctgctcagag gtcactgaac 1900
tatgaagaga tggccggctt tgagttcc,ag gtgat:cgcag aggacagcgg 1950
gcaacccatg cttgcatcca gtg tctc'-gt gtgggtcagc ctcttggatq 2000
ccaatgataa tgccccagag gtggtccagc ct.gt:~ctcag cgatggaaaa 2050
gccagcctct ccgtgcttgt gaat.gcctcc acaggccacc tgctggi:gcc 2100
catcgagact cccaatggct tgggcccagc gggc:actgac; acacctccac 2150
tggccactca cagc:tcccgg cc:attccttt tgac;aaccai: tgt ggcaaga 2200
gatgcaga<a. cgggggcaaa tggagagccc: ctci.acagca tccgcaatgg 2250
aaatgaagcc cacctcttca tcctcaaccc: tcatacgggg cagctgttcg 2300
t.caatgtcac caatgccagc ;gcctc:~t:tu ggagtgagtg ggagctggag 2350
atagtagtag aggaccaggg aagccccccc ttacagaccc gagccctgtt 2900
gagggtcatg tttgtcacca gtgtggacca ~~ct.gagggac tcagcccgca 2450
269

CA 02421388 2003-03-25
agcctggggc cttgagcatg tcgatgctga cggtgatctg cctggctgta 2500
ctgttgggca tcttcgggtt gatcctgcct ctgttc:atgt ccatctgccg 2550
gacagaaaag aaggacaaca gggcctacaa ctgtcgggag gcc.gagtcca 2600
cctaccgcca gcagcccaag aggcccc<~ga aacacattca gaaggcagac 2650
atccacctcg tgcctgtgct caggggtcag gcaggtgagc cttgtgaagt 2700
cgggcagtcc cacaaagatg tggacaagga gg<:gatg<stg gaagcaggct 2750
gggacccctg cctgcaggcc cccttccacc tcacc:ccgac cctgtacagg 2800
acgctgcgta atcaaggcaa ccagggagca ccgg<:ggaga gccgagaggt 2850
gctgcaagac acggtcaacc tcctttt,caa ccatcccagg cagaggaatg 2900
cctcccggga gaacctgaac cttcc~cgagr cccagcc:tgc cacagcaccag 2950
ccacgttcca ggcctctgaa ggttgcaggc agccccacag ggaggctggc 3000
tggagaccag ggcagtgagg aagccccac-3 gaggccacca gcctcctctg 3050
caaccctgag acggcagcga catc:tcaatg gcaaagtgtc ccctgagaaa 3100
gaatcagggc cccgtcagat cctgcggaac ctggtccggc t.gtctgtggc 3150
tgccttcgcc gagcggaacc ccgt:ggagga gctcaca gtg gattctcctc 3200
ctgttcagca aatctcccag ctgctgtcca tgctgc:atca gggccaattc 3250
cagcccaaac caaaccaccg aggaaataag tacttggcca agccaggagg 3300
cagcaggagt gcaatcccag acacagatgg ccc:aagtgca agggctggag 3350
gccagacaga cccagaacag gar,gaagggc ca ttggatcc tgaagaggac 3400
ctctctgtga agcaactgct agaagaagag ctgtcaagtc tgctggaccc 3450
cagcacaggt ctggccctgg acc:ggctgag cgcccctgac ccggcctgga 350C
tggcgagact ctctttgccc ctcacca~:ca actaccgtga caatgtgatc 3550
tccccggatg ctgcagccac ggaggag~~cg aggaccttcc agacgttcgg 3600
caaggcagag gcaccagagc tgagcccaac aggcacgagg ctggccagca 3650
cctttgtctc ggagatgagc tc;actgctgg agatgctgct: ggaacagcgc 3700
tccagcatgc ccgtggaggc cgcctcc:gag gcgc:tgcggc ggca ctcggt 3750
ctgcgggagg accctcagtt tagacttggc: c:accagtgca gcctcaggca 3800
tgaaagtgr_a aggggaccca ggtggaaaga cggg gactga gggcaagagc 3850
agaggcagca gcagcagcag caggtgcctg t:gaacatacc tcagacgcct 3900
ctggatccaa gaaccagggg c:ctegaggatc r_gtggacaag agctggtttc 3950
taaaatcttg taactcacta gcT,agcggcg gccagagaac tttagggtga 4000
ctgatgctac ccccacagag gaggcaagag ccccaggact aacagctgac 4050
'270

CA 02421388 2003-03-25
tgaccaaagc agccccttgt aagcagctct ~_~agtcttt-,_g gaggacaggg 4100
acggtttgtg gctgagataa gt:.gtttcctg gcaaaacata tgtggagcac 4150
aaagggtcag tcctct.ggca gaacagatgc cacggagtat. cac:aggcagg 4200
aaagggtggc cttcttgggt agcaggagtc agggggctgt. accctggggg 9250
tgccaggaaa tgctctctga cctatcaata aaggaaaagc agtaaaaaaa 9300
aaaaaaaaaa aaa 4313
<210> 425
<211> 1109
<212> PRT
<?13> Homo Sapiens
<400> 425
Met. Met GIn Leu Leu Gln Leia Leu Leu Gly Leu Leu C>Iy P.ro Gly
1 5 10 15
Gly Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu
20 25 30
Thr Val Lys Tyr Gln Val Seer Glu Glu Val Pro Ser Cly Thr Val.
35 40 45
Ile Gly Lys Leu Sex Gln Gnu Lei: Gl.y Arcr Glu Glu Arg Arg Arg
50 5'~ 6C
Gln Ala Gly Al.a Ala Phe Gln Vas Leu Gl~.z Leu Pro Gln Ala Leu
6 5 70 75
Pro Ile Gln Val Asp Ser Glu Glu Gly Leu Leu Ser Th r Gly Arg
80 85 90
Arg Leu Asp Arg Glu Gln heu Cys Arg Gln Trp Asp Pro Cys Leu
95 100 105
Val Ser Phe Asp Val Leu Ala Thr Gly Asp Leu Ala Leu Ile His
110 115 120
Val Gl.u Ile Gln Val Leu Asp ILe Asn Asp His Gln Prc: Arg Fhe
125 130 135
Pro Lys Gly Glu Gln Glu Leu Glu Ile ~~er Glu Ser Ala Ser Leu
140 745 150
Arg Thr Arg Ile Pro Leu Asp Arg Al.a ';.eu Asp Pro Asp Thr Gly
155 7 60 165
Pro Asn Thr Leu His Thr T'yr Thr Leu Ser Pro Ser Glu His Phe
170 175 100
Ala Leu Asp Val Ile Val Gly Prc Asp Glu Thr Lys His Ala Glu
185 190 195
Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser Phe Phe
200 205 2.10
Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys Ser
215 220 225
271

CA 02421388 2003-03-25
Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn
230 235 240
Ser Prc Ala Fhe Ala Glu Ser Se.~_ Leu Rl.a Leu Glu Ile Gln Glu
245 250 255
Asp Ala Ala Pro Gly Thr Leu Leu Ire Lys LE:u Thr Ala Thr Asp
2F0 265 270
Pro Asp Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys
275 280 285
His Met Pro Pro Glu Val Leu Ash Tt~r Phe Ser Ile Asp Ala Lys
290 295 300
Thr Gly Gln Val Ile Leu Arg Arg Pao Leu Asp Tyr Glu Lys Asn
305 310 :815
Pro Ala Tyr Glu Val Asp Val Gln A.ia Arg Asp Leu Gly Prc Asn
320 325 :330
Pro Ile Pro Ala His Cys Lys Val Leu Ile Lys Val Leu Asp Val
335 390 395
Asn Asp Asn Ile Pro Ser Ile His V<il Thr Trp Ala Ser Gln Prc
350 35~:~ 360
Ser Leu Val Ser Glu Ala Leu Pro Lys Asp Ser Phe Ile Ala Leu
365 370 375
Val Met Ala Asp Asp Leu Asp Ser Gly His Asn Gly Leu Vai His
380 j8'i 390
Cys Trp Leu Ser Gln Glu Leu Gly His Phe Arg Leu Lys Arc_ Thr
395 900 405
Asn Gly Asn Thr Tyr Met Leu LE:u Thr Asn Ala Thr Leu Asp Arg
97.C 915 920
G'~u Gln Trp Fro Lys Tyr Thr Leu Thr l.,eu Leu Ala Gln Asp Gln
925 430 435
Gly Leu Gln Fro Leu Ser Aia Lys L~ys Gln heu Ser Ile Gln Ile
990 495 950
Ser Asp Ile Asn Asp Asn Ala Pro V'al Phe Glu Lys Ser Arg Tyr
455 960 965
Glu Val Ser Thr Arg Glu Asn Asn Iaeu Pro :aer Leu His Leu Ile
470 475 980
Thr Ile Lys Ala His Asp Ala Asp l.~eu Gly ;1e Asn Gly Lys Val
985 490 495
Ser Tyr Arg Ile Gln Asp Ser Pro Val Al.a His Leu Val Ala Ile
500 505 510
Asp Ser Asn Thr Gly Glu Val Thr Ala Gln i~rg Ser Leu Asn Tyr
515 520 525
Glu Glu Met Ala Gly Phe Glu Phe (~ln Val Ile Ala Glu Asp Ser
530 535 590
2a.

CA 02421388 2003-03-25
Gly Gln Pro Met Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu
545 550 555
Leu Asp Ala Asn Asp Asn Ala Pro Glu 'v'al Val Glr: Pro Val Leu
560 5F5 570
Ser Asp Gly Lys Ala Ser Leu Ser Val Leu Val Asn Ala Ser Thr
575 580 585
Gly His Leu Leu Val Pro Ile Glu Thr Pro Asn Gly Leu Gly Pro
590 595 600
Ala Gly Thr Asp Thr Pro Pro Leu Ala 'nhr His Ser Ser Arg Pro
605 610 615
Phe Leu Leu Thr 'Ihr Ile Val A-~a Arg Asp F.la Asp Ser Gly Ala
620 625 630
Asn Gly Glu Pro Leu Tyr Ser Ile Arg Asn C~ly Asn Glu Ala His
635 fig ~ 695
Leu Phe Ile Leu Asn Pro fii.s Thr Gly Gln Leu Phe Val Asn Val
650 655 660
Thr Asn Ala Ser Ser Leu Ile Gly ;per Glu 'Trp Glu Leu Glu Ile
665 670 675
Val Val Glu Asp Gln Gly Ser Pro Fro Leu C~lr. Thr Arg Ala Leu
680 685 690
Leu Arg Val Met Phe Val Thr S~~r Val Asp His Leu Arg Asp Ser
695 700 705
Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Va1 Ile
710 715 720
Cys Leu Ala Vai Leu Leu Gly Ile f'he Gl.y Leu Ile Leu Ala Leu
725 730 735
Phe Met Ser Ile Cys Ar_q Thr Glu Lys Lys Asp Asn Arg Ala Tyr
740 795 750
Asn Cys Arg Glu Ala Glu Ser Thr '1'yr Arg Gln Gln Pro Lys Arg
755 '7Ei0 765
Fro Gln Lys His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val
770 775 780
Leu Arg Gly Gln Ala Gly Glu Pro c.,ys Glu b'al Gly Gln Ser His
785 790 795
Lys Asp Val Asp Lys Glu Ala Met Met Glu .~la Gly Trp Asp Pro
800 8G5 81C
Cys Leu Gln Ala Pro Phe His Leu Thr Pro Thr Leu Tyr Arg Thr
815 82'0 ~025
Leu Arg Asn Gln Gly Asn Gln Cly Ala Pro Ala Glu Ser Arg Glu
830 835 890
Val Leu Gln Asp Thr Val Asn L,eu :Leu Phe Asn His Pro Arg Gln
845 850 855
2 '7 3

CA 02421388 2003-03-25
Arg Asn Ala Ser Arg Glu Asn Leu Asn Leu Pro Glu Pro Gln Pro
860 865 870
Ala Thr Gly Gln Pro Arg Ser ,Arg P.ro Leu Lys Val. Ala Gly Ser
875 880 885
Pro Thr Gly Arg Leu Ala G1y Asp GIn G1y S~~r Glu Glu A1a Pro
890 895 900
Gln Arg Fro Pro Aia Ser Ser Ala Thr Leu Arg Arg Gln Arc His
905 910 915
Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro Arg Gln
920 925 930
Ile Leu Arg Ser Leu Val Arg LE:u Ser Val Ala Ala Phe Ala Glu
935 990 945
Arg Asn Pro Val. Glu Glu Leu Thr Val Asp ~er Pro Pro Vai Gln
950 955 960
Gln Ile Ser Gln Leu Leu Ser Leu l.eu His C~ln Gly Glr. Phe Gln
965 970 975
Pro Lys Pro Asn His Arg Giy Asn I,ys Tyr I~eu Ala Lys Pro Gly
98(7 985 990
Gly Ser Arg Ser Ala Ile Pro Asp 'I'hr Asp Gly Pro Ser Ala Arg
995 1000 1005
Ala Gly Gly Gln Th.r Asp Pro Glu Gln Glu Glu Gly Pro Leu Asp
1010 1015 1020
Pro Glu Glu Asp Leu Ser Val Lys Gln Leu Leu Glu Gl.u Glu Leu
1025 10?0 1035
Ser Ser Leu Leu Asp Pro Ser Thr ,1y Leu Ala Leu Asp Arg Leu
1090 1045 1050
Ser Ala Pro Asp Pro Ala Trp Met Ala Arg Leu Ser Leu Prc Leu
1055 10Ei0 1065
Thr Thr Asn Tyr Arg Asp Asr: Va1 Ile Ser Pro Asp Ala A:a Ala
10'70 10'75 1080
Thr Glu Glu Pro Arg Thr Phe Gln Thr Phe Gly Lys Al.a Glu Ala
1085 1090 1095
Pro Glu Leu Ser Pro Thr Gly 'Phr Arg Leu Ala Ser Thr Phe Val
1100 1105 1110
Ser Glu Met Ser Ser Leu Leu Glu Met Leu Leu Glu Gi.n Arq_ Ser
1115 1120 1.125
Ser Met Pro Val Glu Al.a Al.a Ser Glu Ala Leu Arg Arg Lec.z Ser
1130 1135 1190
Val Cys Gly Arg Thr Leu Ser Leu Asp I.,eu A.la Thr Ser Ala Ala
1195 1150 1155
Ser Gly Met Lys Val Gln Gly Asp Pro Gly Gly Lys Thr Gly Thr
11E;0 1165 11'10
2 ?4

CA 02421388 2003-03-25
Glu Gly Lys Ser Arg Gly Ser Ser Ser Ser Ser Arg Cys Leu
1175 1180
<210> 426
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 926
gtaagcacat gcctccagag gtgc 24
<210> 927
<211> 29
<212> DNA
<2i3> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 427
gtgacgtgga tgcttgggat gttg 29
<210> 428
<211> 50
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-50
<223> Artificial Sequence
<900> 928
tggacacctt cagtattgat gccaagacag gccaggtcat tctgcgtcga 50
<210> 929
<211> 2037
<212> DNA
<213> Homo Sapiens
<400> 929
cggacgcgtg ggcggacgcg tgggggagaa ccgcagt:ccc ggctgcagca 50
cctgggagaa ggcagaccgt gtgagggggc° ctgtggc~ccc agcgtgctgt 100
ggcctcgggg agtgggaagt ggaggcagg<i gccttcctta cacttcgcca 150
tgagtttcct catcgactcc agcatcatg._i tt.acct~,:cca gatactattt 200
tttggatttg ggtggctttt cttcatgcg~: caattgttta aagactatga 250
gatacgtcag tatgttgtac aggtgatctt ctcc:gtgacg tttgcatttt 300
cttgcaccat gtttgagctc atcatctttg aaatcttagg agtattgaat 350
2'75

CA 02421388 2003-03-25
agcagctccc gttattttca ctggaaaatg aacctgtgt:g taattctgct 400
gatcct.ggtt ttcatggtgc ctttttac.at tggctatttt attgt.gagca 450
atatccgact actgcataaa caacgactgc t ttttt.cctg tctcttatgg 500
ctgaccttta tgtatttctt ctggaaa cta ggagatccct ttcccattct 550
cagcc-caaaa catgggatct tatccataga a~cagctcatc agccgggttg 600
gtgtgattgg agtgactctc atggctcttc tttctggatt tggtgctgtc 650
aactgcccat acacttacat gtcttacttc ~~tcaggaatg tgactgacac 700
ggatattcta gccctggaac ggcgac:tgct gcaaaccatg gatatgatca 750
taagcaaaaa gaaaaggatg gcaatggcac ggaga<scaat gtt:ccagaag 800
ggggaagtgc ataacaaacc atcaggtttc tggggaat.ga taaaaagtgt 850
taccacttca gcatcaggaa gtgaaaatct tactcttatt caacaggaag 900
tggatgcttt ggaagaatta agcaggcagc tttttctgga aacagctgat 950
ctatatgcta ccaaggagag aatagaatac tcc:aaaac~ct tcaaggggaa 1000
atattttaat tttcttggtt actttttctc ta~~tt:acvgt gtttggaaaa 1050
ttttcatggc taccatcaat attgtttttg atcgagttgg gaaaacggat 1100
cctgtcacaa gaggcattga gatcactgtg aattatctgg gaatccaatt 1150
tgatgtgaag ttttggtccc aacacatttc ctt.cattctt gttggaat.aa 1200
tcatcgtcac atccatcaga ggattgctga tcactcttac caagttcttt. 1250
tatgccatct ctagcagtaa gtcct.ccaat gtcattgtcc tgctattagc 1300
acagataatg ggcatgt.act ttgtc~tcctc: tatgctc~ctg atccgaatga 1350
gtatgccttt agaataccgc accar_aatc~; ctgaagtcct tggagaactg 1900
cagttcaact tctatcaccg ttggtttgat gtgatcitcc tggtcagcgc 1950
tctctctagc atactcttcc tctatttggr tcacaaa cag gcaccagaga 1500
agcaaatggc accttgaact taagcctact acagactgtt agaggccagt 1550
ggtttcaaaa tttagatata agagggggga aaaatggaac cagggcctga 1600
cattttataa acaaacaaaa tgctatggta gcat:ttttca ccttcatagc 1650
atactccttc cccgtcaggt gatact:atga ccat=gagtag c:atcagccag 1700
aacatgagag ggagaactaa ctcaagacaa tactcagcag agagcatccc 1750
gtgtggatat gaggctggtg tagaggcgga gaggacccaa gaaactaaag 1800
gtgaaaaata cactggaact ctggggcaag acatgt.ctat ggtagctgag 1850
ccaaacacgt aggatttccg ttttaaggt.t cacatggaaa aggttatagc 1900
tttgccttga gattgactca ttaaaatcag agactgtaac aaaaaaaaaa 1950
276

CA 02421388 2003-03-25
aaaaaaaaaa agggcggccg cgactctaga gtcgacctcac agaagcttgg 2000
ccgccatggc ccaacttgtt tattgcagct tataatg :%037
<210> 430
<2I1> 455
<2i2> PRT
<.273> Homo sapiens
<400> 430
Met Ser Phe Leu Ile Asp Ser Ser Ile Mei= Ile Thr Ser Gln Ile
1 5 10 15
Leu Phe Phe Gly Phe Gly Trp Leu Phe Phe filet Arc:l Gln Lea Fhe
20 25 30
Lys Asp Tyr Glu Ile Arg Gln T-yr Val Val c~ln Va.L Ile Phe Ser
35 40 45
Val Thr Phe Ala Phe Ser Cys Thr Met Phe Glu Leu Ile Ile Phe
50 55 60
C:lu Ile Leu Gly Val Leu Asn Ser Ser Seer Arg Tyr Phe His Trp
65 70 75
hys Met Asn Leu Cys Val Ile Leu Leu Ile Leu Val Phe Met Val
80 :>5 90
Pro Phe Tyr ile Gly Tyr Phe Ile Val Ser Asn Il.e Arg Leu Leu
95 100 105
His Lys Gln Arg Leu Leu Phe~ Ser Cys L~au Leu Tt:p Leu Thr Phe
110 115 120
Met Tyr Phe Phe Trp Lys Leu Gly Asp Pro Phe Pro Ile Leu Ser
125 130 135
Pro Lys His Gly I1e Leu Ser Ile Glu Gln Leu Ile Ser Arg Val
190 145 150
Gly Val. Ile Gly Val Thr Leu Met Ala L,eu Leu Ser Gly Fhe Gly
155 160 165
Ala Val Asn Cys Pro Tyr Thr Tyr Met Ser Tyr Fhe Leu Arg Asn
170 ~-75 180
Val Thr Asp Thr Asp Ile Leu Ala Leu Glu Arg Arg Leu Leu Gln
185 190 195
Thr Met Asp Met: 11e Ile Ser Lys. Lys Ly:~ Arg Met Ala Met Ala
20C 205 210
Arg Arg Thr Met Phe Gln Lys Gly Glu Va:. His Asn Lys .Pro Ser
215 220 225
Gly Phe Trp Gly Met Ile Lys Ser Val Th:r Thr Ser A1a Sex Gly
230 23 ~~ 240
Ser Glu Asn Leu Thr Leu Ile Gln Gln Glu Val Asp A1a Leu Glu
245 25(7 255
Glu Leu Ser Arg Gln Leu Phe Lea Glu Thr Ala Asp Leu Tyr Ala
;? 7 7

CA 02421388 2003-03-25
260 265 270
Th r Lys Glu Arg Ile Glu Tyr Ser Lys Thr Phe Lys Gly Lys Tyr
275 280 285
Phe Asn Phe Leu Gly Tyr Phe Phe Ser Ile Zyr Cys Val Trp Lys
290 295 300
Ile Phe Met Ala Thr Ile Asn Ile Val I?he F~sp Arg Val Gly Lys
30'i 310 31.5
Thr Asp Pro Val Thr Arg Gly Ile t,lu Ile ~~hr Val Asn Tyr Leu
320 325 330
Gly Ile Gln F~he Asp Val Lys Phe '!'rp Ser ~~ln His Ile Ser Phe
335 340 345
Ile Leu Val Gly Ile Ile Ile Val Thr Ser Ile Arg Gly Leu Leu
350 355 360
Ile Thr Leu Thr Lys Phe Phe Tyr .Alts Ile Ser Ser Ser Lys Ser
365 370 375
Ser Asn Val Ile Val Leu Leu Leu Ala Gln Il.e Met Gly Met Tyr
380 385 390
Phe Val Ser Ser Val Leu Leu Ile Arg Met Ser Met Pro Leu Glu
395 900 405
Tyr Arg Thr Ile Ile Thr Glu Val Leu Gly Glu Leu Gln Phe Asn
410 415 420
Phe Tyr His Arg Trp PY~e Asp Val Ile Phe Leu Val Ser Ala Leu
425 430 435
Ser Ser Ile Leu Phe Leu Tyr Leu Alts His Lys Gln Ala F'ro Glu
490 945 450
Lys Gln Met Ala Fro
455
<210> 931
<211> 407
~:212> DNA
<213> Homo Sapiens
<220>
<221> unsure
<222> 78, 81, 113, 15;, 229, 29'
<223> unknown base
<400> 931
catgggaagt ggagccggag ccttccttac act.cg:~catg agtttcctca 50
tcgactccag catcatgatt accts cccnga nactattttt tggatttggg 100
tggcttttct tcngcgccaa tgttt:aaaga ctatgagata cgtcagtatg 150
ttgtacnggt gatcttctcc gtgac:gtttg ccatttcttg caccatgttt 200
gagctcatca tctttgaaat ctr_nggaqta ttgaatagca gctcccgtta 250
ttttcactgg aaaatgaacc tgtgtgtaat tctgc:tgatc ctggttntca 300
278

CA 02421388 2003-03-25
tggtgccttt ttacattggc tattttattg tgagcaatat ccgactactg 350
cataaacaac gactgctttt ttcctgtctc ttat:ggctga cctttat.gta 400
tttCCag 4~7
<210> 932
<211> 457
<212> DNA
<213> Homo Sapiens
<220>
<221> unsure
<222> 31, 6F, 81-82, 89, 122, 184, 187, 2:~2, 291, 900, 424, 427, 439
<223> unknown base
<400> 432
gtgttgccct tggggagggg aaggggagcc nggecctttc ctaaaatttg 50
gccaagggtt tctttnttga attccgggtt nngnatacct tcccagaaaa 100
tattttttgg atttggggta gntttttttc atgcgccaat tgtttaaaga 150
ctatgagata cgtcagt.atg ttgt<~caggt gatnttntcc gt:gacgtttg 200
cattttcttg caccatgttt gagctcatca tntttgaaat nt=taggagta 250
ttgaatagca gctcccgtta ttttcactgci aaaatge3ar_c tgtgtgtaat 300
tctgctgatc <a ggttttca tggtgcctt~ ttacat:.ggc tattttattg 350
tgagcaatat ccgactactg cataaacaac gactgctttt ttcctgtctn 400
ttatggctga cctttatgta tttnttntgg aaantaggag atccctttcc 450
cattctc 457
<210> 433
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 433
aagtggagcc ggagccttcc 20
<210> 934
<211> 22
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-22
<223> Artificial Sequence
<900> 434
tcgttgttta tgcagtagtc gg 22
279

CA 02421388 2003-03-25
<210> 435
<211> 9i
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> l.-41
<223> Artificial Sequence
<900> 935
attgtttaaa gactatgaga t.acgtcagta tgttgtac~ag g 41
<210> 936
<211> 3951
<212> DNA
<213> Homo sapiens
<900> 936
ctcgcgcagg gatcgtccca tggccggggc tcggagccgc gacccttggg 50
gggcctccgg gatttgctac ctttttggct ccctgctcgt cgaactgctc: 100
ttctcacggg ctgtcgcctt caatctggac- gtgatgctgtg ccttgcgcaa 7.50
ggagggcgag ccaggcagcc tcttcggctt ctct:gtggcc ctgcaccggc 200
agttgcagcc ccgaccccag agctggctgc tggtgg3tgc tccccaggcc 250
ctggctcttc ctgggcagca ggcgaatcgc actc7gaggcc t.cttcgctt.g 300
cccgttgagc ctggaggaga ctgact:gcta cag<~gtggac atcgaccagg 350
gagctgatat gcaaaaggaa agcaaggaga accagtggtt. gggagtcagt 900
gttcggagcc aggggcctgg gggcaagatt gttaccagtg cacaccgata 45G
tgaggcaagg cagcgagtgg accagatcc:t ggagacgcgg gatatgattg 500
gtcgctgctt tgtgctcagc: caggacct~~g ccatcc~ggga tgagttggat 550
ggtggggaat ggaagttctg tgagggacgc ccc:caaggcc atgaacaatt 600
tqggttctgc cagcagggca cagctgccgc ctt:ctcccct gatagccact 650
acctcctctt tggggcccca ggaacctata attggaaggg cacggccagg 700
gtggagctct gtgcacaggg ctcagcggac ctggc:acacc tggacgacgg 750
tccctacgag gcggggggag agaaggagca ggacccccgc ctcatcccgg 800
tccctgccaa cagctactt.t ggcttctca a ttgactcggg gaaaggtctg 850
gtgcgtgcag aagagctgag ctttgtggct ggagcccccc gcgccaacca 900
caagggtgct gtggtcatcc tgcgcaagga cagcgccagt cgcctggtgc 950
ccgaggttat gctgtctggg gagcgcctga cca ccggctt tggctac;tca 1000
ctggctgtgg ctgacctcaa c~:gt=gatggc t.ggccagacc: tgatagtggg 1050
tgccccctac ttctttgagc gccaagaaga gctggggggt gct.gtgtatg 1100
280

CA 02421388 2003-03-25
tgtacttgaa ccaggggggt cactgggc:tg ggatct=cccc tctccggctc 1150
tgcggctccc ctgactccat gttcgggatc agcct:~gctg i:.cctggggga 1200
cctcaaccaa gatggctttc cagataittgc agtgggtgcc ccctttgatg 1250
gtgatgggaa agtcttcatc taccat:.ggga gcagcct<~gg ggttgtcgcc 1300
aaaccttcac aggtgctgga gggcgaggct gtgggca~~ca ag;agcttcgg 1350
ctactccctg tcaggcagct tggatatgga tgggaac~~aa taccctgacc 1400
tgctggtggg ctccctggct gacaccgcag tgct<a tcag ggccagaccc 1450
atcctccatg tctcccatga ggtctctatt gctccacgaa gcatcgacct 1500
ggagcagccc aactgtgctg gcggc:cactc ggtctgtgtg gacctaaggg 1550
tctgtttcag ctacatt:gca gtccc cagca gctatagccc tactgt.ggcc 1600
ctggactatg tgttagatgc ggac.acagac: cggaggctcc ggggccaggt 1650
tccccgtgtg acgttcctga gccgtaacct ggaagaac<:c aagcaccagg 1700
cctcgggcac cgtgtggct.g aagcaccagc atgaccgagt ctgtggagac 1750
gccatgttcc agctccagga aaatgtcaaa gacaagcttc gggccattet 1800
agtgaccttg tcctacagtc tccagaccctcggctccgg cgacaggctc 1850
ctggccaggg gctgcctcca gtggccccca tcctcaatgc ccaccagcc:c 1900
agcacccagc gggcagagat ccacttcctg aagcaaggct gtggtgaaga 1950
caagatctgc cagagcaatc tgcag~;tgcrt ccacg<.~ccgc ttctgtaccc 2000
gggtcagcga cacggaattc caacctctc~c c~catgc~atgt ggatggaaca 2050
acagccctgt ttgcactgag tgggcagcca gtcattggcc tggagctgat 2100
ggtcaccaac ctgccatcgg acccagccca gcc:ccaggct gatggggatg 2150
atgcccatga agcccagct:: ctggtcatgc ttcctgactc actgcact.ac 2200
tcaggggtcc gggccctgga cccagcggag aagccactct gcctgtcc:aa 2250
tgagaatgcc tcccatgttg agt:gtgagct ggggaacccc atgaagagag 2300
gtgcccaggt. caccttctac ctcatcctta gcacctccgg gatcagcat.t 2350
gagaccacgg aactggaggt agagctgc:tg tt.ggccacga tcagtgagca 2400
ggagctgcat ccagtctctg racgagc<;cg tgtcttcatt gagctgccac 2450
tgtccattgc aggaatggcc attccccagc aactcttctt ctctggtgtg 2500
gtgaggggcg agagagccat gc:agtctgag cgggatgt.gg gcagcaaggt 2550
caagtatgag gtcacggttt cc:aaccaagg ccagtcgctc: agoaccctgg 2600
gctctgcctt cctcaacatc atgtggcctc atgagattgc caatgggaag 2650
231

CA 02421388 2003-03-25
tggttgctgt acccaatgca ggttgagctg gagggc:gggc aggggcctgg 2700
gcagaaaggg ctttgctctc ccaggc:c<:aa catcc:tccac <;tggatgtgg 2750
acagtaggga taggaggcgg cgggagctgg agccacct:ga gcagcaggag 2800
cctggtgagc ggcaggagcc c:agcatgtcc tggtggcc:ag tgtcctctgc 2850
tgagaagaag aaaaacatca <:cctggactg cgcccggc.~gc acggccaact 2900
gtgtggtgtt cagctgccca ca ctacagct ttgac:cgcgc ggctgtgctg 2950
catgtctggg gccgtctctg gaacagcacc tttct~ggagg agtactcagc: 3000
tgtgaagtcc ctggaagtga ttgtccgggc caacatcaca gt.gaagtcct 3050
ccataaagaa cttgatgctc cgagatgcct ccacagt.gat cc:cagtgatg 3100
gtatacttgg acc:ccatggc tgtggtggca gaaggac)tgc cct.ggtgggt 3150
catcctcctg gctgtactgg ctgggctgct ggtgctagca ctgctggtgc 3200
tgctcctgtg gaagatggga ttcttcaaac. gggcga,sgca ccccgaggcc 3250
accgtgcccc agtaccatgc ggtgaagatt. cctc;gggaag accgacagca 3300
gttcaaggag gagaagacgg gcaccatcct gaggaacaac tggggcagcc 3350
cccggcggga gggcccggat gcacacccc:a tcc~gcctgc: t.gacaggcat 3400
cccgagctgg gccccgatgg gcar_ccaggg ccaggcaccg cctaggttcc 3450
catgtcccag cctggcctgt ggctgccct.c catcccttcc ccagagatgg 3500
ctccttggga tgaagagggta agagtggg:~t gctggtgtcg catcaagatt 3550
tggcaggatc ggcttcctca ggggcacaga cctctcccac ccacaagaac 3600
tcctcccacc caacttcccc ttagagtgct gtgagatgag agtgggtaaa 3650
tcagggacag ggccatgggg tagggtgaga agggcagggg tgtcctgatg 3700
caaaggtggg gagaagggat cctaatcoct tc~~tc:tccca ttcacccLgt 3750
gtaacaggac cccaaggacc tg~~ctccc-:cg gaagt_gcctt aacctaga_qg 3800
gtcggggagg aggttgtgtc actgactcag gctgc,tcctt ctctagtttc 3850
ccctctcatc tgaccttagt ttgctgc<~at cagt~tagtg gtttcgtggt 3900
ttcgtctatt tattaaaaaa tatt.tgagaa caaaaaaaaa aaaaaaaaaa 3950
a 3951
<210> 437
<2i1> 1191
<212> PRT
<213> Homo sapiens
<400> 437
Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile
1 5 10 15
282

CA 02421388 2003-03-25
Cys Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg
20 25 30
Ala Val. Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu
35 40 45
Gly Glu Pro Gly Ser Leu Phe Gly I~he Ser ~~'al Ala Leu His Arg
50 55 60
G1n Leu Gln Pro Arg Pro Gln Ser Trp Leu Leu Val Giy Ala Pro
65 70 75
Gln Ala Leu Ala Leu Pro Giy Gln Gln A-i.a Asn Arg Thr Gly Gly
EO 85 90
Leu Phe Ala Cys Pro Leu Ser Leu Glu Glu Thr Asp Cys Tyr Arg
95 100 1.05
Val Asp Ile Asp Gln Gly Ala Asp Met Gln Lys Glu Ser Lys Glu
110 115 120
Asn Gln Trp Leu Gly Val Ser Val Arg ier Gln Gly Prc Gly Gly
125 130 135
Lys Ile Val Thr Cys Ala His Arg T'yr Glu Ala Arg Gln Arg Val
140 145. 150
Asp Gln Ile Leu Glu Thr Arg As~~ Met Ile Gly Arg Cys Phe Val
155 360 165
Leu Ser Gln Asp Leu Ala I1e Arg Asp Glu Leu Asp Gly Gly Glu
170 17~ 180
Trp Lys Phe Cys Glu Gly Arc Pry G1n Gly His Glu Gln Phe Gly
185 190 195
Phe Cys Gln Gln Gly Thr Ala Ala Aia Phe Ser Pro Asp Ser His
200 205 210
Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly Thr
215 2<t0 225
Ala Arg Va1 Glu Leu Cys Ala G'~n Gly Ser Ala Asp Leu Ala His
230 235 24C
Leu Asp Asp Gly Fro Tyr Glu A1a Gly Gly Glu Lys Glu Gln Asp
245 250 255
Pro Arg Leu Ile Pro Val Pr_o Ala Asn Ser Tyr Phe Gly Phe Ser
260 265 270
I1e Asp Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe
275 .%8C) 285
Val Ala Gly Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile
290 ~'95 300
Leu Arg Lys Asp Ser Ala Ser Arg Leu Val Pro Glu Val Met Leu
305 31.0 315
Ser Gly Glu Arg Leu Thr Ser Gly Phe Gly Tyr Ser Leu Ala Val
320 325 330
283

CA 02421388 2003-03-25
Ala Asp Leu Asn Ser Asp Gly Trp Pro Asp Leu Ile Val Gly Ala
335 340 395
Pro Tyr Phe Phe Glu Arg Gln G:Lu Glu Leu Gly Gly Ala Val Tyr
350 35.5 360
Val Tyr Leu Asn Gln Gly Gly His Trp Ala C~ly Ile Ser Pro Leu
36'.p 370 375
Arg Leu Cys Gly Ser Pro AsF Ser Met Fhe ~.~ly Ile Ser Leu Ala
380 385 390
Val Leu Gly Asp Leu Asn Glrv Asp Gly Fhe Fro Asp Ile A1a Val
395 900 405
Gly Ala Pro Fhe Asp Gly Asp Gly Lys Val Phe Iie Tyr His Gly
910 415 420
Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val Leu Glu Gly
425 430 435
Glu Ala Val GIy Ile Lys Ser Phe Gly Tyr Ser Leu Ser Gly Ser
990 945 450
Leu Asp Met Asp Gly Asn Gin Tyr Pro Asp Leu heu Val Gly Ser
455 46C 96'i
Leu Ala Asp Thr Ala Val Leu Phe Arg Ala Arg F?ro Ile Leu His
470 975 4$0
Val Ser His Glu Vai Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu
985 490 995
Gln Pro Asn Cys Ala Gly C;ly His Ser Val Cys Val Asp Leu Arg
500 505 510
Val Cys Phe Ser Tyr Ile Ala Val Pro Ser Ser 'I'yr Ser Pro Thr
51.5 52 0 525
Val Ala Leu Asp Tyr Val Leu Asp Ala Asp Thr Asp Arg Arg Leu
530 535 540
Arg Gly Gln Val Pro Arg Val Thr Phe L~2u Ser Arg Asn Leu Glu
545 550 555
Glu Pro Lys His Gln Ala Ser Gl.y 'I'hr Val Trp Leu Lys His Gln
560 565 570
His Asp Arg Val Cys Gly Asp Ala Met Fhe Gln Leu Gln Glu Asn
575 580 585
Val Lys Asp Lys Leu Arg A1a ~le Val Va7. Thr Leu Ser Tyr Ser
590 595 600
Leu Gln Thr Pro Arg Leu P.rg Arg Gl.n Ala Pro Gly Gln Gly Leu
605 610 615
Fro Pro Val Ala Pro Ile Leu Asn A:La His Gln Pro Ser Thr Gln
620 625 630
Arg Ala Glu Ile His Phe Leu Lys Gln Gly Cys G1y Glu Asp Lys
635 690 695
289

CA 02421388 2003-03-25
I1e Cys Gin Ser Asn Leu Gln Leu Val His P.la ArG Phe Cys Thr
650 655 660
Arg Val Ser Asp Thr Glu Phe Gln Fro Leu Prcu MeC Asp Val Asp
665 670 675
Gly Thr Thr Ala Leu Phe Ala Leu per Gly Gln Prn Va1 Ile Gly
680 685 b90
Leu Glu Leu Met Val 'rhr Asn heu e'ro Ser Asp Pro Ala Gln Pro
695 700 705
Gln Ala Asp G1y Asp Asp Ala His Glu ALa Gln Leu Leu Val Met
710 X15 720
Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg A:La Leu Asp Pro
725 730 735
Ala Glu Lys Pro Leu Cys Leu Ser Asn Glu Asn Ala Ser His Val
740 745 750
Glu Cys Glu Leu Gly Asn Pro Met Lys Arg Gly Ala Gln ~'al Thr
755 760 76_'.
Fhe Tyr Leu Ile Leu Ser Thr Ser Gl.y Ile: Ser Ile Glu Thr Thr
770 775 780
Giu Leu Glu Val Glu Leu Leu Lei Ala Thr Ile :3er Glu Gln Glu
785 790 795
Leu His Pro Val Ser Ala Arg Ala Arg Val Phe Ile Glu Leu Pro
800 805 810
Leu Ser Ile Ala Gly Met hla Ile Pro Gln Gin Leu Phe Phe Ser
815 820 825
Gly Val Val Arg Gly G1u Arg Ala Met Gln Ser Glu Arg Asp Val
830 835 840
Gly Ser Lys Val Lys Tyr Glu Val Thr Val Ser Asn Gln Gly Gl.n
895 8~0 855
Ser Leu Arg Thr Leu Gly Ser Ala Phe Leu Asn Iie Met Trp Pro
860 865 870
His Glu Ile Ala Asn Gly LVS Trp Leu Leu Tyr Pre Me!. Gln Val
875 J E80 885
Glu Leu Glu Gly Gly Gln G1y Fro Gly Gln Ly.s Gly Leu Cys Ser
8901 f395 900
Pro Arg Pro Asn Ile Leu Hi.s i~eu Asp 'Jal Asp Ser Arg Asp Arg
905 910 915
Arg Arg Arg Glu Lea Glu Pro Pro G:lu <>ln Gln Glu Pro Gly Glu
920 925 930
Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu
935 990 945
Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg Giy Thr Ala Asn
950 955 960
285

CA 02421388 2003-03-25
CysValValFheSerCysPro LeuI'yrSer PheAspArgAla
Ala


965 970 975


ValLeuHisValTrpGlyArg LeuirpAsn ,perThrPheLeu
Glu


980 985 990


C~luTyrSerAlaValLysSer LeuGluVal IleValArgAla
Asn


995 1000 1005


IleThrValLys5erSerIle LysAsnLeu MetLeuArgAsp
Ala


1010 1015 1020


SerThrValIleProValMet 'JalTyrL~euAspProMetAla
Val


1025 1030 1035


ValAlaGluGlyValPrcTrp TrpValIle LeuLeuAlaVa.1
Leu


1040 1095 1050


AlaGlyLeuLeuValLeuAia LeuLeuVal LeuLeuLeuTrp
Lys


1055 106C 1065


MetGlyPhePheLysArgAia Ly:HisPro GluAlaThrVal
Pro


1070 107c> 1080


GlnTyrHisAlaValLysIle ProArgGlu AspArgGlnGln
Phe


1085 109;) 1095


LysGluGluLysThrGlyThr IleLeuArg AsnAsnTrpGly
Ser


1100 1105 1110


PreArgArgGluGlyProlispAnaHisPro Il.eLeuAlaAla
Asp


7.115 110 1125


GlyHisProGluLeuGlyPro A:pGlyHis ProGlyProGly
Thr


11:30 l 1140
1~j5


Ala
<210> 438
<211> 24
<212> DNA
<213> Artificial.
<220>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<400> 438
ggctgacacc gcagtgctct tcag 24
<210> 439
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<900> 439
286

CA 02421388 2003-03-25
gctgctgggg act.gcaatgt agct 24
<210> 440
<211> 46
.212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-46
<22?> Artificial Sequence
<400> 440
catcctccat gtctcccatg aggtctctae: tgctcc<3cga agcatc 46
<210> 941
<211> 1964
<212> DNA
<=.213> Homo sapiens
<400> 441
cgcgccgggc gcagggagct gagtggacgg ctcgagacgg cggcgcgtgc 50
agcagctcca gaaagcagcg agttggcaga gcagggctgc atttccagca 100
ggagctgcga gcacagtgct. ggctcacaac aagatgctca aggtgtcagc 150
cgtactgtgt gtgtgtgcag ccqcttggtg cagtcagtct ctcgcagctg 200
ccgcggcggt ggctgcagcc ggggggcggt cggacggcgg taattttc:tg 250
gat:gataaac aatggctcac ca<:aatctct cagtatgaca aggaagtcgg 300
acagtggaac aaattccgag acgaagt«ga ggatgattat ttcc:gcactt 350
ggagtccagg aaaaccctt:c gatcagg~at: taga~ccagc taaggatcca 400
tgcttaaaga t_qaaatgtag tcgccataaa gtatgcattg ctcaagattc 450
tcagactgca gtctgcatta gtcaccggag gcttaca<:ac aggatgaaag S00
aagcaggagt agaccatagg cagtggaggg gtcc:catatt atccacctgc 550
aagcagtgcc cagtggtc:ta tcccagc:cct gttt:gtggtt cagatggtca 600
tacctactct tttcagtgca aactagaata tca<xgcatgt gtcttaggaa 650
aacagatctc agtcaaatgt gaaggac;att acc~atgtcc ttcagataag 700
cccaccagta caagcagaaa tgttaagaga gcatgcagtg acctggagtt 750
cagggaagtg gcaaacagat tgcgggactg gttcaaggcc cttcat~gaaa 800
gtggaagtca aaacaagaag acaaaaacat tgctgaggcc taagagaagc 850
agattcgata ccagcat.ctt gccaatttgc aaggactcac ttggctggat 900
gtttaacaga cttgatacaa actatgacct gctattggac cagtcagagc 950
tcagaagcat ttaccttgat aagaatgaac agtgtaccaa ggcattcttc 1000
aattcttgtg acacatacaa ggacagtita atatctaata atgagtggtg 1050
287

CA 02421388 2003-03-25
ctactgcttc cagagacagc aagac<:cacc ttgc:cag~.ct gagctcagca 1100
atattcagaa gcggcaaggg gtaaayaagc tc<:taggaca gtatat:cccc 1150
ctgtgtgatg aagatggtta caacaagcca acacaatgtc atggcagtgt 1200
tggacagtgc tggtgtgttg acagatatgg aaatc7aagtc atgggatcca 1250
gaataaatgg tgttgcagat tgtgcaatag attttgagat ctccggagat. 1300
tttgctagtg gcgattttca tgaatgcxact gatgatc,agg atgatgaaga 1350
cgatattatg aatgatgaag atgaaattga agatgat:gat gaagatgaag 1400
gggatgatga t:gatggtggt gatgaccat<3 atgt:at<~cat ttgattgatg 1450
acagttgaaa tcaataaatt ctacatttct aatatttaca aaaatgatag 1500
cctatttaaa attatcttct tccccaataa caaaatgatt ctaaacctca 1550
catatatttt gt.ataattat ttgaaaaatt gcagctaaag t:tatagaact 1600
ttatgtttaa ataagaatca ttt.gcttt<.:a gttttt:atat tccttaca~~a 1650
aaaagaaaat acatatgcag tctagtcaya caaaa':aaag ttttgaagtg 1700
ctactataat aaatttttca cgagaacaaa ctt.tgtaaat cttccataag 1750
caaaatgaca gctagtgctt gggat:cgtac atgttaatt.t tttgaaagat 1800
aattctaagt gaaat.ttaaa ataaa taaat ttttaatgac ctgqgtcT_ta 1850
aggatttagg aaaaatatgc atgctttaat tgcat:ttcca aagtagcatc 1900
ttgctagacc tagatgagt:c aggataa~:ag agagatacca catgactcca 1950
aaaaaaaaaa aaaa 1964
<210> 442
<211> 936
<2i2> PRT
<213> Homo sapiens
<400> 442
Met Leu Lys Val Ser Ala Val ~~eu Cys Val Cys Ala Ala Aia Trp
1 5 10 15
Cys Ser Gln Ser Leu Ala fila Ala A1a Ala Val Ala Ala AIa Gly
20 25 30
Gly Arg Ser Asp Gly Gly Asn Phe Leu Asp Asp Lys Gin Trp Leu
35 40 45
Thr Thr Ile 5er Gln Tyr Asp Lys Glu Val Gly G'yn Trp Asn Lys
50 'a5 60
Phe Arg Asp Glu Val Glu Asp Asp T'yr Phe Arg Thr Trp Ser Pro
65 70 75
Gl.y Lys Pro Fhe Asp Gln Ala Leu Asp Pro Ala Lys Asp Pro Cys
80 85 90
Leu Lys Met Lys Cys Ser Arg His Ly;> Val C:ys Ile Ala Gln Asp
288

CA 02421388 2003-03-25
95 100 105
Ser Gln Thr Ala Val Cys Iie Ser His Arg llrg Leu Thr His Arg
110 11.5 1.20
Met Lys Glu Ala Gly Val. Asp His Arg Gl.n Trp Arg Gly Pro Tle
125 130 135
Leu Ser Thr Cys Lys Gln Cys Pro Val Val Tyr Fro Ser Pro Val
140 1~5 150
Cys Gly Ser Asp Gly His Thr 'ryr Ser Phe Gln Cys Lys Leu G1u
155 160 165
Tyr Gln Ala Cys Val Leu Gly Lys Glu Ile Ser Val Lys Cys Glu
170 175 180
G1y His Cys Pro Cys Pro Ser Asp Lys Pro Thr Ser Thr Ser Arg
185 190 195
Asn Val Lys Arg Ala Cys Ser Asp Leo Glu Phe Arg Glu Val Ala
200 205 210
Asn Arg Leu Arg Asp Trp Phe Ly: Ala Leu His Glu Ser Gly Se:r
215 220 225
Gln Asn Lys Lys Thr Lys Thr Leu Leu Arg Pro Glu Arg Ser Arg
230 235 290
Phe Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp
245 250 255
Met Phe Asn Arg Leu Asp 'Phr An Tyr Asp Leu Leu Leu Asp Gln
260 265 2'70
Ser Glu Leu Arg Ser Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr
275 280 285
Lys Ala Phe Phe Asn Ser Cys Asp Thr Tyr Lys Asp Ser Leu I1e
290 295 300
Ser Asn Asn Glu Trp Cys Tyr C:ys Phe Gln Arg Gln Gln Asp Pro
305 a10 315
Pro Cys Gln Thr C>1u Leu Ser Asn Ile c;ln Lys Arg Gln Gly Val
320 325 330
Lys Lys Leu Leu Gly Gln Tyr Ile Pro Leu Cys Asp Glu Asp Gly
335 340 345
Tyr Tyr Lys Pro Thr Gln Cys Hi.s Gly Ser Val Gly Gin Cys Trp
350 355 360
Cys Val Asp Arg Tyr Gly .Asn Glu Val Met G:Ly Ser Arg Ile Asn
365 370 375
Gly Val Ala Asp Cys Ala Ile Asp Phe Glu Ile Ser Gly Asp Phe
38C 3R5 390
Ala Ser Gly Asp Phe His Glu Trp 'rhr Asp Asp Glu Asp Asp Glu
395 400 405
Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu Asp Asp Asp Glu
289

CA 02421388 2003-03-25
410 415 420
Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His Asp Jal Tyr
425 430 435
Tle
<210> 443
<211> 25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-25
<223> Artificial Sequence
<400> 443
cagcaatatt cagaagcggc aaggg 25
<210> 449
<211> 28
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> ~-28
<223> Artificial Sequence
<400> 449
catcatggtc atcaccacc:a tcatcatc: 28
<210> 44'
<211> 98
<212> DNA
<213> Artificial
<220>
<22i> Artific.iai Sequence
<222> 1-48
<223> Artificial Sequence
<400> 945
ggt.tactaca agccaacaca atgtcatggc agtgttggac agtgctgg 48
<210> 446
<211> 361'l
<212> DNA
<213> Homo sapiens
<400> 946
cagactccag atttccctgt caaccacgag gagtccagag aggaaacgcg 50
gagcggagac aacagtacct gacgcctctt. tcagcccggg atcgccccag 100
cagggatggg cgacaagatc tggctgccct tccccgtgct ccttctggcc 150
gctctgcctc cggtgctgct gcctggggcg gccggctt:ca caccatccct 200
cgatagcgac ttcaccttta cccttcccgc cggccagaag gagtgcttct 250
290

CA 02421388 2003-03-25
accagcccat gcccctgaag gcctcgctgg agatcgagta ccaagtt:tta 300
gatggagcag gattagatat t:gatttccat ct.tgcctctc cagaaggcaa 350
aaccttagtt tttgaacaaa gaaaatcaga tggagttrac actgtagaga 400
ctgaagttgg tgattacatg ttctactttg acaat:acatt cagcaccatt: 450
tctgagaagg tgattttctt tgaatta atc ctggataata tgggagaaca 500
ggcacaagaa caagaagatt ggaagaaata tattact:ggc acagatat_ar- 550
tggatatgaa actggaagac atcctggaar ccatcaacag catcaagtcc 600
agactaagca aaagtgggca catacaaatt ctgcttagag catttgaagc 650
tcgtgatcga aacatacaag aaagcaactt: tgat~agagtc aatttctggt 700
ctatggttaa tttagtggtc atggtggtc,g tgtcagcr:at tcaagtttat 750
atgctgaaga gtctgtttga agataa gaqg aaaagt:agaa cttaaaactc 800
caaactagag tacgtaacat_ tgaaaaatcaa qgc;atasaaaa tgcaataaac 850
tgttacagtc aagaccatta atggtcttct ccaaaatatt ttgagatata 900
aaagtaggaa acaggtataa ttttaatgtg aaaattaagt cttcactttc 950
tgtgcaagta atcct.gctga tcc;agttgta ct-.aagtgtg taacaggaat 1000
attttgcaga atataggttt aactgaatga agcc<3tatta ataactgcat 1050
tttcctaact ttgaaaaat:t. ttgcaaa~.gt cttag gtgat ttaaataaat 1100
gagtattggg cctaattgca acaccagr_ct gtttttaaca ggttctatta 1150
cccagaactt ttttgtaaat gcggcagtta c<aaattaact gtggaagttt 1200
tcagttttaa gttataaatc acct:gagaat to ccaaatga tggattgaat 1250
aaatctttag actacaaaag ccc,sactttt ctctatttac atatgcatct 1300
ctcctataat gtaaat:agaa taatagctt:t gaaatacaat taggtttttg 1350
agatttttat aaccaaatac atttcagtgt uacatattag cagaaagcat 1900
tagtcttt.gt actttgctta cattcccaaa <igctgacatt ttcacgattc 1950
ttaaaaacac aaagttacac t.tactaaaat tac,gacatgt tttctctttg 1500
aaatgaagaa tat:agtttaa aag ctt.cctc ctccataggg acacattttc 1550
tctaaccctt aactaaagtg taggat.ttta aaatt:aaatg tgaggtaaaa 1600
taagtttatt tttaatagta tctgtcaagt taatatctgt caacagttaa 1650
taatcatgtt atgttaattt taacatgatt gctgacttgg ataattcatt 1700
attaccagca gttatgaagg aaatattgct aGaatgatct gggcctacca 1750
taaataaata tctccttttc tgagc.tctaa gaattatcag aaaacaggaa 1800
agaatttaga aaaacttgag aaaac:ctaat cc~aaaataaa attcacttaa 1850
291

CA 02421388 2003-03-25
gtagaactat aaataaatat ctagaatctg actggctcat catgacatcc 1900
t:actcataac at:aaatcaaa ggagatgatt aattt:cc,sgt tagctggaag 1950
aaactttggc tgtaggtttt tattttc:tac aagaattctg gtttgaatta 2000
tttttgtaag caggtacatt ttataaaatg taagccctac tqtaaggttt: 2050
agcactgggt qtacatattt attaaaaatt tttattataa caacttttat. 2100
taaaatggcc t.ttctgaaca ctttatttat tgatgtt:gaa gtaaggatta 2150
gaaacataga ctcccaagtt ttaaacacct aaatgtgaat aacccat.ata 2200
tacaacaaag tttcagccat ctagcttttt gaagtctatg ggggtcttac 2250
tcaagtacta gtaatttaac ttcatc-atga atgaactata atttttaagt 2300
tatgcccatt tataacgttg tttatgacta cattgt.gagt tagaaacaaa 2350
cttaaaattt ggggtataga accc:ctcaac aggttagtaa tgctggaatt 2400
cttgatgagc aataatgata accagaga~yt gat:tt~:attt acactcatag 2950
tagtataaaa agagatacat ttccca ct~~a ggc:ccctggg agaagagcag 2500
cttagatttc cctactggca aggtttttaa aaatgaggta aatgccgt.at 25_'0
atgatcaatt accttaattg gcc:aagaaaa tgctt.caggt gtctaggggt 2600
atcctctgca acacttgcag aacaaag<tc aataagatcc ttgcctatga 2650
atacccctcc cttttgcgct gttaaatttg caatgagaag caaatttaca 2700
gtaccataac taataaagca gggt.acagat at:aaactact gcatcttttc 2750
tataaaactg tgattaagaa ttct:acctct cctgtatggc tgttactgta 2800
ctgtactctc tgactcctta cctaacaatg aatttgttac ataatcttct 2850
acatgtatga tttgtgcc:ac tgatcttaaa cct<3tgattc agtaacttct 2900
taccatataa aaacgataat tgctttatt,' ggaaaagaat ttaggaatac 2950
taaggacaat tatttttat.a aacaaagtaa aaagacagat atttaagagg 3000
cataaccaaa aaagcaaaac t.tgtaaacag <~gtaaaaatc tttaat_attt 3050
ctaaagacat actgtttatc tgcttcatat gcttttttt:a atttcactat 3100
tccatttcta aattaaagtt atgctaaat.t gagtaagctg tttatcactt 3150
aacagctcat tttgtctttt tcaatatac a aav.tttaaaa atactacaat 3200
atttaactaa ggcccaa ccg atttccataa tgtagcagtt accgtgttca 3250
cctcacacta aggcctagag tttgctctga tatgcatttg gat:gattaat 3300
gttatgctgt tctttcatgt gaatgtcaag ac:atggaggg tgtttgtaat 3350
tttatggtaa aattaatcct tcttacacat aatggtgtct taaaattgac 3400
292

CA 02421388 2003-03-25
aaaaaatgag cacttacaat tgtatgtctc ctcaaatgaa gattctttat 3950
gtgaaatttt aaaagacatt gattc~:g::at gtaaggattt ttcatctgaa 3500
gtacaataat gcacaatcag tgttgctcaa actgcttv.at acttataaac 3550
agccatctta aataagcaa~: gtattgtgag t,actc(atatg tatataataa 3600
aaattatcaa aggaaaa 3617
<210> 447
<217> 229
<212> PRT
<213> Homo sapiens
<400> 447
Met Gly Asp Lys Ile Trp Leu Pra Phe Pro Val. Leu Leu L,eu Ala
1 5 1U 15
Ala Leu Pro Pro Val Leu Leu Pre Gly Ala Ala Gly Phe ~'hr Pro
20 2~. 30
Ser Leu Asp Ser Asp Phe Th r Phe Thr Leu Pro Ala Gly Gin Lys
35 40 45
Glu Cys Phe Tyr Gln I?ro Met Pr;,Leu Lys Ala Ser Leu Glu Ile
50 55 60
Glu Tyr Gln Val Leu Asp Gly Ala Gly Leu Asp Ile Asp Phe His
65 70 75
Leu Ala Ser Pro Glu Gly Lys Thr Leu Val Phe Glu Gln Arg Lys
80 85 90
Ser Asp Gly Val H=s Thr Val Glu Thr G:L.u Val Gly Asp Tyr Met
Q5 1 JO 105
Phe Cys Phe Asp Asn Thr Phe Ser Thr Ile Ser Glu Lys Val Ile
110 11 '. 120
Phe Phe Glu Leu Ile Leu Asp Asn Met Gly Glu Gln Alm Gln Glu
125 7.30 135
Gln Glu Asp Trp Lys Lys Tyr Ile Thr Gly Thr Asp Ile heu Asp
140 195 150
Met Lys Leu Glu Asp Ile I_~eu ~~lu Ser Ile Asn Ser Ile hys Ser
155 160 165
Arg Leu Ser Lys Ser Gls.~ flis Ile Gln Ile Leu Leu Arg Ala Phe
170 175 180
Glu Ala Arg Asp Arg Asn Ile Gln Glu Ser Asn Phe Asp Arg Val
185 190 195
Asn Phe Trp Ser Met Val Asn Leu Val Val Met Val Val Val Ser
200 205 210
Ala Ile Gln Val Tyr Met Leu Lys Ser Leu Phe Glu Asp Lys Arg
215 220 225
Lys Ser Arg Thr
293

CA 02421388 2003-03-25
<210> 448
<211> 23
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-23
<223> Artificial Sequence
<400> 498
cccagcaggg ctgggcgaca aga 23
<210> 499
<:211> 2 3
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-23
<223> Artificial Sequence
<400> 949
gtcttcc:.agt ttcatatcca ata 23
<210> 450
<211> 93
<212> DNA
<213> Artifi-cial
<220>
<221> Artificial Sequence
<222> 1-43
<223> Artificial Sequence
<400> 450
ccagaaggag cacggggaag ggcagcc:aga tcttgtcgcc: cat 43
<210> 451
<21I> 859
<'~ 12 > DNA
<213> Home sapiens
<400> 451
ccatccctga gatcttttta taaaaaaccc <~gtctttgct gaccagacaa 50
agcataccag atctcaccag agagtc:gcag acactatgc:t gcctcccatg 100
gccctgccca gtgtgtcctg gatgctgctt tcc:tgcctca ttctcctgtg 150
tcaggttcaa ggtgaagaaa cccagaagga act.gccctct ccacggatca 200
gctgtcccaa aggctccaag gcctatggct ccccctgcta tgccttgttt 250
ttgtcaccaa aatcctggat ggatgcagat ctggcttgcc agaagcggcc 300
ctctggaaaa ctggtgtctg tgctcagtgg ggctgaggga tccttecgtgt 350
cctccct.ggt gaggagcatt agtaacagct acacatacat ctggattggg 400
ctccatgacc ccacacaggg ctctgagcct g<~tggagatg gatgggagtg 450
294

CA 02421388 2003-03-25
gagtagcact gatgtgatga attactttgc atgggag.jaa aat.ccctcca 500
ccatcttaaa ccctggccac tgtgggGgcc tgtcaagaag cacaggattt 550
ctgaagtgga aagattataa ctgtgat:gca aagt:r_accct atgtctgca<~ 600
gttcaaggac t.agggcagGt gggaag=cag cagcctc:agc ttggcgtgca 650
gctcatcatg gacatgagac cagtgtgaacr actcaccctg gaagagaata 700
ttctccccaa actgccctac ctgactacct_ tgtcat~~atc ctccttcttt 750
ttccttt.ttc ttcaccttca t.ttcaggctt ttctctgtct tccatgtcit. 800
gagatctcag agaataataa taaaaatgtt actttataaa aaaaaaaaaa 850
aaaaaaaaa 859
<21 0> 452
<211> 175
<212> PRT
<213> Homo sapi.ens
<900> 452
Met Leu Pro Pro Met Ala Leu E'ro Ser Val Ser Trp Met Leu Leu
1 5 10 15
Ser Cys Leu Ile Leu Leu ~~ys Gin Val Gl.n Gly Glu Glu Thr Gln
c: 0 a' S 3 0
Lys Glu Leu Pro Ser Pro Arg I.e Ser Cys Pro Lys Gly Ser Lys
35 40 95
Ala Tyr Giy Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pre: Lys Ser
5O 55 6O
Trp Met Asp Ala Asp Leu Ala Cys Gln hys Arg Pro Ser Gly Lys
65 7C. 75
Leu Val Ser Val Leu Ser Gly Ala Glu (~ly Ser Phe Val Ser Ser
8(r 85 90
Leu Val Arg Ser Ile Ser Asn Ser Tyr Ser Tyr Ile Trp Ile Gly
95 100 105
Leu His Asp Pro Thr Gln Gly Ser G:Lu Pro Asp Gly Asp Gly Trp
110 115 120
Glu Trp Ser Ser Thr Asp 'Jal Met Asn Tyr Phe Ala Trp Glu Lys
lay 130 135
Asn Pro Ser Thr Iie Leu Asn Pro Gly His Cys Gly Ser Leu Ser
190 145 150
Arg Ser Thr Gly Phe Leu Lys Trp l.,ys Asp Tyr Asn C',ys Asp Ala
155 160 165
Lys Leu Pro Tyr Val Cys Ly:- Phe Lys Asp
170 i75
<210> 453
<211> 5 50
295

CA 02421388 2003-03-25
<212> DNA
<213> Homo sapiens
<400> 453
ccagtctgtc gccacctcac ttggtgtctg ctgtccccgc caggcaagcc 50
tggggtgaga gcacagagga cxtgggccggg accatgcggg ggacgcggct 100
ggcgctcctg gcgctggtgc tggctgcctg cggagagctg gcgccggccc 150
tgcgctgcta cgtctgtccg gagcccacag gagtgtcgga ct.gtgt:cacc: 200
atcgccacct gcaccaccaa cgaaac~~atc; tgcaagacca cactctactc 250
ccgggagata gtgtacccct tccaggggg« ctccacggtg accaagtcct 300
gtgccagcaa gtgtaagccc tcggatgtgr3 atggcatcgg ccagaccctg 350
cccgtgtcct gctgcaatac tgagctgtgc aatgtagacg gggcgcccgc 900
tctgaacagc ctccactgcg gggccctcac gctcctccca ctcttgagc;c 950
tccgactgta gagtccccgc ccacccccat ggccct:atgc ggcccagccc 500
cgaatgcctt gaagaagtgc cccctgcai:c aggaaaaaaa aaaaaaaaaa 550
<210> 459
<2i1> 125
<212> PRT
<213> Homo Sapiens
<400> 459
Met Arg Gly Thr Arg Leu Ala Lc=a Leu Ala Leu Val Leu Ala Ala
1 5 10 15
Cys Gly Glu Leu Ala Fro Ala Leu Arch Cys Tyr Val Cys Pro Glu
20 a5 30
Pro Thr Gly Val Ser Asp Cys Val Thr I1e Ala Thr Cys Thr Thr
35 40 45
Asn Glu Thr Met Cys Lys Thr Thr Leu Tyr Ser Arg Glu Ile Val
50 5°, 60
Tyr Pro Fhe Gln Gly Asp Ser 'Thr Val '1'hr Lys Ser Cys Ala Ser
65 70 75
Lys Cys Lys Pro S2r Asp Val Asp Gly Ile Gly Gln Thr Leu Pro
80 85 90
Val Ser Cys Cys Asn Thr Glu Leu Cys Asn Val Asp Gly Ala Pro
95 100 105
Ala Leu Asn Ser Leu His Cys Gly Ala Leu Thr Leu Leu Pro Leu
110 115 120
Leu Ser Leu Arg Leu
125
<210> 455
<211> 1518
<212> DNA
<213> Homo Sapiens
296

CA 02421388 2003-03-25
<400> 455
ctgcagtcag gactctggga ccgcaggggg ctcccggacc ctgactctgc 'i0
agccgaaccg gcacggtttc gtggggaccc aggcttgcaa agtgacggtc i00
attttctctt tctttctccc. t:.cttgagtcc ttc:tgag,3tg atggctctgg :L50
gcgcagcggg agctacccgg gtctttGtcg cgatggtagc ggcggctctc: 200
ggcggccacc ctctgctggg agtgagc:gcc accttgaact cggttctcaa 250
ttccaacgct atcaagaacc tgcccccacc gctgggc:ggc gctgcggggc 300
acccaggctc tgcagtcagc gccgcgccgg gaatcct:gta cc cgggcggg 350
aataagtacc agaccattga caactaccag ccgt:aci:cgt gcgcagagga 400
cgaggagtgc ggcactgatg agtactgcgc tagt:cccacc cgcggagggg 950
acgcaggcgt gcaaatctgt ctcgcctgca ggaagcgccg aaaacgctgc 500
atgcgtcacg ctatgtgctg ccccgggaat tactgcaaaa atggaatatg 550
tgtgtcttct gatcaaaatc attrc~cgayg agaaat_tgag gaaaccat~ca 600
ctgaaagctt tggtaatgat catagcacc-t t.ggatcxggta ttccagaaga 650
accaccttgt cttcaaaaat. gtatcacac~c aaaggacaag aaggttctgt 700
ttgtctccgg tcatcagact gtgcctcagg attgtgttgt gctagacact 750
tctggtccaa gatctgtaaa cct:gtcctga aagaaggtca agtgtgtacc 800
aagcatagga gaaaaggctc tcatggacta gaaat:attcc agcgttgtta 850
ctgtggagaa ggtctgt.ct.t gccggataca gaaagatcac c atcaagcca 900
gtaattcttc taggcttcac acttgtc,~ga gacawtaaac cagctatcca 950
aatgcagtga actcctttta tataatagat gca atgaaaa ccttttatga 1000
ccttcatcaa ctcaatccta aggatataca agttctgtgg tttcagttaa 1050
gcattccaat aacaccttcc aaaaacctgg agtc,taagag ctttgtttct 1100
ttatggaact cccctgtgat tgcagtaaat tact:gtattg taaattctca 1150
gtgtggcact tacctgtaaa tgcaatgaaa rtt.~:taatta tttttctaaa 1200
ggtgctgcac tgcctatttt tcctcttgtt atgtaaattt ttgt.acacat 1250
tgattgttat cttgactgac aaatattcta tattgaactg aagtaaatca 1300
tttcagctta tagttcttaa aagcataacc ctttacccc:a tttaattcta 1350
gagtctagaa cgcaaggatc t,cttggaat.g acaaatgata ggtacctaaa 1400
atgtaacatg aaaatactag cttatt.ttc:t gaa~atgtact atcttaatgc 1450
ttaaattata tttcccttta ggctgtgata gtttttgaaa taaaatttaa 1500
catttaaaaa aaaaaaaa 151E
297

CA 02421388 2003-03-25
<:210> 456
<211> 266
<212> PRT
<213> Homo Sapiens
<900> 456
Met Met A1a Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala
1 5 10 15
Met Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser
20 25 30
Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu
35 40 45
Pro Pro Pro Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val
50 55 60
Ser Ala Ala Pro Gly Ile Leu Tyr Pro (~ly Gly Asn hys Tyr Gln
65 7C 75
Thr Ile Asp Asn Tyr Gln Pro Tyr Pro wya Ala Gl.u Asp Glu Glu
80 8'9C
Cys Gly Thr Asp Glu Tyr Cys Ala Ser Pr~_~ Thr Arg Gly Gly Asp
95 10~ 105
Ala Gly Va1 Gln Ile Cys LeLn Ala Cys: Arg Lys Arg Arg Lys Arg
110 115 120
Cys Met Arg His Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn
125 130 135
Gly Ile Cys Val Ser Ser Asp G1n Asn H_s Phe Arg Gly <~lu Ile
190 145 150
Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn Asp His Ser Thr Leu
155 160 165
Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser Lys Met. Tyr His
170 175 180
Thr Lys Gly Gln Glu Gly Ser Val Cys heu Arg Ser Ser Asp C:ys
185 190 195
Ala Ser Gly Leu Cys Cys Ala llrg His 1?he Trp Ser Lys Ile Cys
20C 205 210
Lys Pro Val Leu Lys Glu Gly Gln Vr:l Cys Thr Lys His Arg Arg
215 220 225
Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly
230 235 240
Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser
2_95 250 255
Asn Ser Ser Arg Leu His Thr Cys Gln Arg His
260 265
<210> 457
<211> 638
298

CA 02421388 2003-03-25
<212> DNA
<213> Homo sapiens
<220>
<221> unsure
<222> 30, 123, 133, 139, 180, 214, 259, 282, 308, 452, 46'1, 471, 473,
509, 556
<223> unknown base
<400> 45'?
tgtgtttccc tgcagtcaga atttgggacr gcaggggttc ccggac:ctga 50
ttttgcagcg gaacgggaag gttttgtggc; ac:ccaggttg aaatgacggt 100
catttttttt tctttctcct tcng:aagtccv t.tntgag ang atggttttgg 150
gcgcagcggg agctaacccg gttttttgtn gcgatggtag cggcggtttt 200
cggcggccac cttntgctgg gagtgagcgc ca<~cttgaat cggttttcaa 250
ttccaacgnt atcaagaacc tgc<.:cc:cacc gntgggcggc gctgcggg<~c 300
acccaggntt tgcagtcagc gccgcgccgg gaatcc:tgta cccgggcggg 350
aataagtacc agaccattga caattaccag c.cgtac ccgt gcgcagagga 400
cgaggagtgc ggcactgatg agtactgc~3c tagtcc:cacc cgcggagggg 450
angcgggcgt gcaaatntgt ntngcctgca ggaagcgccg aaaacgctgc 500
atgcgtcang ctatgtgctg ccccgggaat tactgcaaaa atggaat<ctg 550
tgtgtnttct gatcaaaatc atttccgagg agaaattgag gaaaccatca 600
ctgaaagctt tggtaatgat catagcacct tggat:ggg E38
<210> 958
<211> 9040
<212> DNA
<213> Homo Sapiens
<900> 458
gaggaaccta ccggtaccgg ccgcgcgctg gtagtcgccg gtgtggctgc 50
acctcaccaa tcccgtgegc cgcggctggg ccgt:cggaga gtcxcgtgtgc 100
ttctctcctg cacgcggtgc ttgggctcgg ccac~gcgggg tccgccgcca 150
gggtttgagg atgggggagt agctacagga agcgaccccg cgatggcaag 200
gtatattttt gtggaatgaa aaggaagtat tagaaatgag ctgaagacca 250
ttcacagatt. aatatttttg <~ggacagatt tgtgatgctt gattcaccct 300
tgaagtaatg tagacagaag tt~~tcaaat:t tgc:atattac atcaactgga 350
accagcagtg aatcttaatg ttcact:taaa tc<igaacttg cataagaaag 400
agaatgggag tctggttaaa taaagatgac tatatcagag acttgaaaag 450
gatcar_tctc tgttttctga tagtgtatat ggccatttta gtgggcacag 500
atcaggattt ttacagttta cttggagtgt ccaaaactgc aagcagtaga 550
299

CA 02421388 2003-03-25
gaaataagac aagctttcaa gaaattggca ttgaagt~ac atcctgataa 600
aaacccgaat aacccaaatg ~:acatgccga ttttt.taaaa ataaatagag 650
catatgaagt actcaaagat gaagatctac ggaaaaagta tgacaaatat 700
ggagaaaagg gacttgagga taatraaggt gg<:cagtatg aaagctggar~ 750
ctattatcgt tatgattttg gtatttatga tgatgatcct gaaat<:ataa 800
cattggaaag aagagaattt gatgctgctc~ tt:aattc:tgg agaactgtgg 850
tttgtaaatt tttactcccc aggctottca cact.gccatg atttagctcc 900
cacatggaga gact:ttgcta aagaagtgga tgggttactt cgaattggag 950
ctgttaactg tggtgatgat agaatgcttt gccgaatgaa aggagtcaac 1000
agctatccca gtctcttcat ttttcggtct ggaatggccc cagtgaaata 1050
tcatggagac agatcaaagg agagtttagt gagttttgca atgcagcatg 1100
ttagaagtac agtgacagaa ctttggacag gaaatt.ttgt caactccata 1150
caaactgctt ttgctgctgg tattggctgg ctgatcactt tttgttcaaa 1200
aggaggagat tgtttgactt cacagacacg ac:tcaggctt agtggcatgt 1250
tgtttctcaa ctcattggat gcta,sagaaa tatat:ttgga agt.aatacat 1300
aatcttccag attttgaaca actttcggca aacacactag aggatcgttt 1350
ggctcatcat cggtggctgt tattttttca tt:ttggaaaa aatgaaaatt 1400
caaatgatcc tgagctgaaa aaaca aaaaa ctctacttaa aaatgatcat 1950
attcaagttg gcaggtttga ct.gttcctct gc:accagaca tctgtagtaa 1500
tctgtatgtt tttcagccgt c~_ctagcagt atttaaagga caaggaacca 1550
aagaatatga aattcatcat ggaaagaaga ttctatatga tatacttgcc 1600
tttgccaaag aaagtgtgaa ttctcat~gtt accacgcttg gacctcaaaa 1650
ttttcctgcc aatgacaaag aaccatggct t:gttgatttc tttgccccc:t 1700
ggtgtccacc atgtcgagct ttactaccag agttacgaag agcatcaaat 1750
cttctttatg gtcagcttaa c~tttgcrtaca ctagattgt:a cagttcatga 1800
gggactctgt aacatgt.ata acattc:aggc ttatccaaca acagtggtat 1850
tcaaccagtc caacattcat gagtat:gaag gac:atcactc tgctgaacaa 1900
atcttggagt tcatagagga tcttatgaat ccttcagtgg tctcccttac 1950
acccaccacc ttcaacgaac tagttacaca aagaaaacac aacgaagtct 2000
ggatggttga tttctattct ccgtggtgtc atccttgc:ca agtct:taatg 2050
cc~agaatgga aaagaatggc ccggacatta ac:tggactga tcaacgtggg 2100
300

CA 02421388 2003-03-25
cagtatagat tgccaacagt atcattcttt ttgtgccc:ag gaaaacgttc 2150
aaagataccc tgagataaga t:tttttcccc caaaatcaaa taaagcttat 2200
cagtatcaca gttacaatgg ttggaatagg gatgc:ttatt ccctgagaat 2250
ctggggtcta ggatttttac ctcaagtatc cacagatcta acacctcaga 2300
ctttcagtga aaaagttcta caagggaaaa atcattoggt gattgatttc 2350
tatgctcctt ggtgtggacc ttgccagaat tt.tgctccag aatttgagct 2400
cttggctagg atgattaaag gaaaagtga<.~ agctggaaaa gtagactgtc 2450
aggcttatgc tcagacatgc cagaaagctc~ ggatcagggc ctatccaact 2500
gttaagtttt atttctacga aagagc:aaag agaaatttt.c aagaagagca 2550
gataaatacc agagatgcaa aagcaatcgc tgccttaata agtgaaaa<~t 2600
tggaaactct ccgaaatcaa ggcaagagga ataaggatga acttt:gataa 2650
tgttgaagat gaagaaaaag tttaaaagaa attctgacag atgacatcag 2700
aagacaccta tttagaatgt: tacatttat:g atgggaatga atgaacatta 2750
tcttagactt gcagttgtac tgccagaat_t atca acagca ctggtgtaaa 2800
agaagggtct gcaaactttt tctgtaaagg gccggtttat aaatatttta 2850
gactttgcag gctataatat atggttcaca catgagaaca agaatagagt 2900
catcatgtat tctttgttat ttGc'_tttaa caacc:tttaa aaaatattaa 2950
aacgattctt. agctcagagc catacaaaag taggctggat tcagtccatg 3000
gaccatagat tgctgtccc:c ctcgacggac ttat~~atgtt tcaggtggct 3050
ggcttgaaca tgagtctgct gtgctatc~t.a cataaatgtc taagttgtat 3100
aaagtccact tt.cccttcac gttttttggc tgacctgaaa agaggtaact 3150
tagtttttgg tcacttgttc t<.:ctaaaaat gctatcccta accatatatt 3200
tatatttcgt tttaaaaaca cccatgatgt ggcacagtaa acaaac~~ctg 3250
ttatgctgta ttattatgag gagattcttc attgttttct ttccttctca 3300
aaggttgaaa aaatgctttt aatttttmcac agc:,gagaaa cagtgcagca 3350
gtatatgtgc acacagtaag tacacaaatt t:gagcaacag taagtgcaca 3400
aattctgtag tttgctgtat cat:ccaggaa a acctgaggg aaaaaaatta 3450
tagcaattaa ctgggcattg tagagt.atcc ta~.atatgt:t atcaagtatt 3500
tagagttcta tattt.taaag atatat:gtgt tcatgtattt tctgaaattg 3550
ctttcataga aattttccca ctgata gttg at!:tttgagg catctaatat 3600
ttacatattt gccttctgaa ctttgttttg acctgtatcc tttatt.taca 3650
ttgggttttt ctttcatagt tttggttttt cactcctgtc cagtctattt 3700
301

CA 02421388 2003-03-25
attattcaaa taggaaaaat tactttacag gttgt.tti:ac. tgtagcttat 3750
aatgatactg tagtt:attc: <?gttactagt ttactgt~::ag agggctgcct 3800
ttttcagata aatattgaca taataac:tga agttattttt ataagaaaat 3850
caagtatata aatctaggaa aggg<atcttc tagt.ttctgt gttgtttaga 3900
ctcaaagaat cacaaatttg tcagtaacat gt.agttc;tt.t agttataatt 3950
cagagtgtac agaatggtaa aaattccaat cagtcaaaag aggtcaatga 4000
attaaaaggc rtgcaacttt ttcaaaaaaa aaaaaaaaaa 9040
<210> 459
~~211 > 747
<212> PRT
<213> I-iomo sapiens
<900> 459
Met Gly Val Trp Leu Asn Lys Asia Asp Tyr Ile Arg Asp Leu Lys
1 5 10 15
Arg Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val
20 2 °~ 30
Gly Thr Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr
35 90 95
Ala Sex Ser Arg Glu Ile Arg Gl.n Ala Pr.e Lys Lys Leu Ala Leu
50 55 60
Lys Leu His Pro Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly
65 'i0 75
Asp Phe Leu Lys Ile Asn Arg ALa Tyr Glu Val Leu Lys Asp Glu
so a5 90
Asp Leu Arg Lys Lys Tyr Asp Lys Tyr Gly Glu Lys Gly Leu Glu
95 100 105
Asp Asn Gln Gly Gly Gln Tyr clu Ser Trp Asn Tyr 'Lyr Arg Tyr
110 115 120
Asp Phe Gly Ile Tyr Asp Asp Asp Pro c;lu Ile I1e 'Phr Leu Glu
12'> 130 135
Arg Arg Glu Phe Asp Ala Ala 'Jal Asn Ser Gly Glu Leu Trp Phe
190 145 150
Val Asn Phe Tyr Ser Pro Gly Cys Ser His Cys His Asp Leu Ala
155 160 165
Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp Gly Leu Leu Arg
170 175 180
Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu Cys Arg Met
185 190 195
Lys Gly Val Asn Ser Tyr Pro Ser l,eu Phe Ile Phe Arg Ser Gly
200 205 210
302

CA 02421388 2003-03-25
Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser heu
215 220 225
Val Ser Phe Ala Mer Gln His Val Arg Ser Thr Val Thr Glu Leu
230 235 240
Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Fhe Ala Ala
245 2 50 255
Gly Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys
260 265 270
Leu Thr Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Phe Leu
275 280 285
Asn Ser Leu Asp Ala Lys Glu Ile Tyr l,eu Glu Val Ile His Asn
290 295 300
Leu Pro Asp Phe Glu Leu Leu Ser Ala Asn Thr I,eu Glu Asp Arg
305 31C 315
Leu Ala His His Arg Trp Leu Leu Phe Phe His Phe Gly Lys Asn
320 325 330
Glu Asn Ser Asn Asp Fro Glu Leu Lys Lys Leu Lys Thr Leu Leu
335 34~ 395
Lys Asn Asp His Ile Gln Val Gly Arq_ Phe Asp Cys Ser 5er Ala
350 355 360
Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe Gln Pro Ser Leu Ala
365 370 375
Val Phe Lys Gly Gln Gly Thr Lys Glu T~ir Glu Ile His His Gly
380 385 390
Lys Lys I.Le Leu Tyr Asp Ile Leu Ala P:ne Ala Lys Glu Ser Val
395 400 905
Asn Ser His Val Thr Thr Leu Gl.y Pro Gln Asn Phe Pro Ala Asn
910 415 420
Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys Pro
42= 430 435
Pro Cys Arg Ala Len Leu Pro f:~lu Leu i?rg Arg Ala Ser Asn Leu
490 445 450
Leu Tyr Gly Gln Leu Lys Fhe Gly Thr Leu Asp Cys Ttr Val His
455 960 465
Glu Gly Leu Cys Asn Met iyr Asn I=Le Gln Ala Tyr Pro Thr Thr
470 475 480
Val Val Phe Asn Gln Ser Asn Ile His Glu Tvrr Glu Gly His His
485 990 495
Ser Ala Glu Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro
500 505. 510
Ser Val Val Ser Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr
515 520 525
303

CA 02421388 2003-03-25
Gln Arg Lys His Asn Glu Val Trp hlet Val Asp Phe Tyr Ser Pro
530 535 540
Trp Cys His Pro Cys Gln Val Leu Met Pro (_~lu Trp Lys Arg Met
545 550 555
Ala Arg Thr Leu Thr G1y Leu Ile Asn Val G1y Ser Ile Asp Cys
560 565 570
Gln Gln Tyr His Ser Phe Cys Ala Gln Glu Asn Val Gln Arg Tyr
5~?5 580 585
Pra Glu Ile Arg Phe Phe Pro Pro Lys Ser Asn Lys Ala Tyr G1n
590 595 600
Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu Arg
605 610 615
Ile Trp Gly Leu G1y Phe Leu Pro Gln Val Ser Thr Asp Leu Thr
620 625 630
Pro Gln Thr Phe Ser Glu Lys VaLeu Gln C~ly Lys Asn His Trp
635 640 695
Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe
650 655 660
Ala Pro Glu Phe Glu Leu lieu Ala Arg Met Ile Lys Gly Lys Val
665 670 6?5
Lys Al.a Giy Lys Val Asp c:ys Gln Ala Tyr A1a Gln Thr Cys G.ln
680 6f.5 690
Lys Ala Gl.y Ile Arg Ala Tyr Pro 'rhr V.al Lys Phe Tyr Phe Tyr
695 700 705
Glu Arg Ala Lys Arg Asn Phe Gln Glu G.lu GIn Ile Asn Thr Arg
710 715 l20
Asp Ala Lys Ala Ile Ala Ala I.~eu Ile F>ex: Glu Lys Leu Glu Thr
'J2'. '?30 735
Leu Arg Asn Gln Gly Lys Arg isn Lys Asp Glu Leu
'14(J 795
<2I0> 460
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> i-29
<223> Artificial Sequence
<400> 460
actccccagg ctgttcacac tgcc 29
<210> 961
<211> 24
<212> DNA
<2i3> Artificial
304

CA 02421388 2003-03-25
<220>
<221> Artificial Sequence
<222> i-24
<'223> Artificial Sequence
<400> 461
gatcagccag ccaataccag cagc 2~
<210> 962
<211> 50
<212> DNA
<213> Artificial
<220>
<221.> Artificial Sequence
<~222> 1-50
<:223> Artificial Sequence
<900> 462
gtggtgatga tagaatgctt tgccgaatga aaggagtcaa cagctatccc 50
<210> 463
<211> 1818
<212> DNA
<213> Homo sapi.ens
<40C> 463
agacagtacc tcctccctag gac:tacacaa ggactgaacc agaaggaaga 50
ggacagagca aagccatgaa catcatccvt.a gaaatccttc t.gcttctgat 100
caccatcatc tactcctac;t tggagtcgtt ggtgaagttt ttcattcctc 150
agaggagaaa atctgtggct ggggagattg tt:ctcattac tggagct.ggg 200
catggaatag gcaggcagac tacttatgaa tttgcaaaac gacagagcat 250
attggttctg tgggatatta at.aagcgcgg tgtggaggaa actgcagctg 300
agtgccgaaa actaggcgtc actgc:g<.:~atg cgtatgtggt agactgcagc 350
aacagagaag agatctatcg ctctct.iaat c:aggtgaaga aagaagtggg 400
tgatgtaac:a atcgtggtga ataatgctgg gacagtatat ccagccgatc 950
ttctcagcac caaggatgaa gagattacca agacatttga ggtcaacatc 500
ctaggacatt tttggatcac: <3aaagc-actt ctt:ccatcga tgatggagag 550
aaatcatggc cacatcgtca ~~agtgclcttc agt:.gtgcgg<: cacgaaggga 600
ttccttacct catcccatat tgttccagca aatttgccgc tgttggcttt 650
cacagaggtc tgacat;:aga acatcaggcc ttgggaaaaa ctggtatcaa 700
aacctcatgt ctctgcccag tttttgtgaa tactgggttc accaaaaatc 750
caagcacaag attatggcct gtattggaga cagatgaagt cgtaagaagt 800
ctgatagatg gaatacttac caataagaaa a~gatttttg ttccatcgta 850
tatcaatatc tttctgagac tacagaagtt tcttcctgaa cgcgcctcag 900
305

CA 02421388 2003-03-25
cgattttaaa tcgtatgcag aatattcaat ttgaagcagt ggttggccac 950
aaaatcaaaa tgaaatgaat aaataagctc cagccagaga tgtatgcat.g 1000
ataatgatat gaatagtttc gaatcaatgc tgc~aaag<at tatttcacat 1050
tttttcagtc ctgataatat taaaaacatt ggtttggcac tagcagcagt 1100
caaacgaaca agattaatta cctgtcttcc tgtt:t:ctcaa gaatatttac 1150
gtagtttttc ataggtctgt tttt<.ctttc atgcctctt:a aaaacttctg 1200
tgcttacata aacatactta aaaggttttc tttaagatat tt:tatttttc 1250
catttaaagg tggacaaaag ctacctccct aaaagtaaat acaaagagaa 1300
cttatttaca cagggaaggt ttaagactgt tcaagtagca ttccaatctg 1350
tagccatgcc acagaatatc aacaagaaca cagaatgagt gcacagc:taa 1400
gagatcaagt ttcagcaggc agc;rttatct caa~~ctggac atatttta<ig 1450
attcagcatt tgaaagattt. ccctagcctc ttcctt:tttc:attagcccaa 1500
aacggtgcaa ctctattctca gactttatta cttgar.tctg tcttctgtat 1550
aactctgaag tccaccaaaa gtggaccctc tatatttcct ccctttttat 1600
agtcttataa gatacattat gaaaggtgac cgactctat:t ttaaatct_ca 1650
gaattttaag ttctagcccc atgataacct ttttcat.tgt aatttatgct 1700
ttcatatatc: cttggtccca gagatgttta gacaatttta ggctcaaaaa 1750
ttaaagctaa cacaggaaaa ggaactgtac tcgctattac ataagaaaca 1800
atggacccaa gagaagaa 181E
<210> 469
<211> 300
<212> PRT
<213> Homo Sapiens
<400> 469
Met Asn Ile Ile Leu Glu Iie L.eu Leu Leu Leu Iie Tt~r Ile Ile
1 5 10 15
Tyr Ser Tyr Leu Glu Ser Leu val Lys Phe Phe Ile Fro Gln Arg
20 25 30
Arg Lys Ser Val Ala Gly Glu I1e Val Leu Ile Thr Gly Ala Gly
35 40 95
His Gly Tle Gly Arg Gln Thr Thr Tyr Glu Phe Ala Lys Arg Gln
50 55 60
Ser Ile Leu Val Leu Trp Asp Ile Asr_ Lys Arg Gly Val Glu Glu
65 70 75
Thr Ala Ala Glu C:ys Arg Lys Leu Gly Val Thr Ala His Ala Tyr
80 85 90
Val Val Asp Cys Ser Asn Arg Glu Glu Ile Tyr Arg Ser Leu Asn
306

CA 02421388 2003-03-25
95 100 105
Gln Val Lys Lys Glu Val G.ly Asp Val Thr lle Val Val Asn Asn
110 L15 120
Ala Gly Thr Val Tyr Pro Ala Asp Leu Leu Ser Thr Lys Asp Glu
125 130 135
Glu Ile Thr Lys Thr Phe Gl.u Val Asn Ile Leu Gly His Phe Trp
140 145 150
lle Thr Lys Ala Leu Leu Pro Ser Met Met Glu Arg Asn His Gly
155 160 165
His Tle Val Thr Val Ala Se:r Val Cys Gly His Glu Gly !:1e Pro
170 175 180
Tyr Leu Ile Pro Tyr Cys Ser Ser Lys Phe Ala Ala Val Gly Phe
i85 190 195
Hi.s Arg G1y Leu Thr Ser G.Lu Leu Gln Ala Leu Gly Lys Thr Gly
200 205 210
ale Lys Thr Ser Cys Leu Cys Prc~ Val Phe Val Asn Thr Gly Phe
215 220 225
Thr Lys Asn Pro Ser Thr Arg Leu Trp Pro Val Leu Glu Thr Asp
230 235 240
Glu Val Val Arg Ser Leu I.le AsP~ Gly Ile Leu 'Thr Asn Lys Lys
295 25(7 255
Met Ile Phe 'Jal Pro Ser Tyr I1<> Asn Ile Phe Leu Arg Leu Gln
260 26.'i 270
Lys Phe Leu Pro Glu Arg Al.a SeAla Ile Leu Asn Arg Met Gln
275 28» 285
Asn Ile Gln Phe Glu Ala Val Val Gly His Lys Iie Lys Met Lys
290 29, 300
<210> 465
<211> 154'7
<212> bNA
<213> Homo Sapiens
<400> 965
cggcggcggc tgcgggcgcg aggtgagggg cgc:gaggtga gg ggcgcgag 50
gttcccagca ggatgccccg gctctgcagg aagctgaagt gagaggcccg 100
gagagggccc agcccgcccg gggcaggat.g accaaggcc:c ggctgttccg 150
gctgtggctg gtgctggggt cggtgttcat gat:cctgct_g atcatcgtgt 200
actgggacag cgc:aggcgcc gcgcacttc:t acttgcacac gtccttct:ct 250
aggccgcaca cggggccgcc gctgc;ccacg cccgggccgg acagggac;ag 300
ggagctcacg gccgactccg atgtcgacga gtttctggac aagttt.ctca 350
gtgctggcgt gaagcagagc gaccttccca gaaaggagac ggagcagccg 900
30i

CA 02421388 2003-03-25
cctgcgccgg ggagcatgga ggagagcgt~x agaggctacg actggtcccc 950
gcgcgacgcc cggcgcagcc cagacc:aggg ccggcagcag gcggagcgga 500
ggagcgtgct gcggggcttc t:gcc;cc:aact ccagcctggc cttccccacc 550
aaggagcgcg cattcgacga catccccaac tcggagctga gccacctgat 600
cgtggacgac cggcacgggg ccatct=actg ctacgtgccc aaggtggcct 650
gcaccaactg gaagcgcgtg atgatcgtgc tgagcggaag cctgctgcac 700
cgcggtgcgc cctaccgcga cccgctgcgc atcccccgcg agcacgtgca 750
caacgccagc gcgcacctga cctt~caacaa gttctc(gcgc cgctacggga 800
agctctcccg ccacctcatg aaggt~~aacac tcaagaagta caccaagtwe 850
ctcttcgtgc gcgacccctt cgtgcgcci:g atctcc:gcct r_ccgcagcaa 900
gttcgagctg gagaacgagg agttctacc:~g caagticgcc gtgcccatgc 950
tgcggctgta cgccaaccac accagcctctc ccgcctcggc gc:gcgaggcc 1000
ttccgcgctg gcctcaaggt gtccttcgc:c aacttcatcc agtacctgct 1050
ggacccgcac acggagaagc tggcgccctt c:aacgagcac tggcggcagg 1100
tgtaccgcct ctgccacccg tgccagatcg act.acgactt cgtggggaag 1150
ctggagactc tggacgagga cgccgcgcag ctgctgcagc tactccaggt 1200
ggaccggcag ctccgcttcc ccccgagcta ccggaacagg accgccagca 1250
gctgggagga ggactggttc gccaagatc:c ccctggcctg gaggcagcag 1300
ctgtataaac tctacgaggc cgactttgtt ctcttcggct accccaaqcc 1350
cgaaaacctc ctccgagact. gaaagctttc gc:gttgcttt ttctcgcgtg 1900
cctggaacct gacgcacgcg cactccagtt tt.tttatgac ctacgatttt 1450
gcaatctggg cttcttgttc actccactgc ctctatccat tgagtacr_gt 1500
atcgatattg ttttttaaga ttaatatatt tcagcttattt aatacga 1597
<21.0> 466
<211> 414
<27.2> PRT
<213> Homo sapiens
<400> 966
Met Thr Lys Ala Arg Leu Phe Arg Leu Trp Leu Val Leu Gly Ser
1 5 10 15
Val Phe Met Ile Leu Leu Ile I1e Val Tyr Trp Asp Ser Al.a Gly
20 ~5 30
Ala Ala His Phe Tyr Leu His T~~r Ser Phe Ser Arg Pro His Thr
35 40 45
Gly Pro Pro Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu
50 55 60
308

CA 02421388 2003-03-25
Thr Ala Asp Ser Asp Val Asp Glu Phe Leu Asp Lys Phe Leu Ser
65 7U 75
Ala Gly Val Lys GLn Ser Asp Leu Pro Arg Lys Glu Thr Glu Gln
80 85 90
Pro Pro A1a Pro Gly Ser Met Glu Glu Ser Val. Arg Gly Tyr Asp
95 100 105
Trp Ser Prc Arg Asp Ala Arg Ara Ser Prc Asp C~ln Gly Arg Gln
110 115 120
Gln Ala Glu Arg Arg Ser Val Leu Arg Gly Phe C'ys Ala Asn Ser
i25 130 135
Ser Leu Ala Phe Pro Thr L.,~s G1~: Arg Ala Phe Asp Asp Lle Pro
140 195 150
Asn Ser Glu Leu Ser Hi.s Leu Ile Val Asp Asp Arg His GLy Ala
155 160 165
Ile Tyr Cys Tyr Vai Pro Lys Va.Ala Cys Thr Asn Trp Lys Arg
170 17!. 180
Val Met Ile Val Leu Ser Gly Ser Leu Leu His Arg Gly Ala Pro
185 190 195
Tyr Arg Asp Pro Leu Arg Ile Pr;~ Arg Glu His Val His Asn Ala
200 205 210
Ser Ala His Leu Thr Phe Asn Lys Phe Trp Arg Arg Tyr Gly Lys
215 220 225
Leu Ser Arg His Leu Met Lys Val Lys Leu Lys Lys Tyr Thr Lys
230 235 290
Phe Leu Phe Val Arg Asp 1'ro Fhe Val Arg Leu Ile Ser Ala Phe
295 250 255
Arg Ser Lys Phe G1u Leu Glu Asn Glu Glu Phe Tyr Arg Lys Phe
260 265 270
Ala Val Pro Met Leu Arg Leu Tyr Al.a Assn His Thr Ser Leu Pro
275 280 285
Ala Ser Ala Arg Glu Ala Phe Arg Ala Gly Leu Lys Val Ser Phe
290 295 300
Ala Asn Phe Ile Gln Tyr Leu Leu Asp Pro His Thr Glu Lys Leu
305 3:10 315
Ala Pro Phe Asn Glu His Trp Aog G.ln Val Tyr Arg Leu Cys His
320 325 330
Pre Cys Gln Ile Asp Tyr Asp Pt:e Val Gly Lys Leu Glu Thr Leu
335 390 395
Asp Glu Asp Ala A1a Gln Leu Leu Gln Leu Leu Gln Val Asp Arg
350 355 360
Gln Leu Arg Phe Pro Pro Ser Tyr Arg Asn Arg Thr Ala Ser Ser
365 370 375
309

CA 02421388 2003-03-25
Trp Glu Glu Asp Trp Phe A~.a Lys Ile Pro Leu Ala Trp Arg Gln
380
3 8 '~
390
Gln Leu Tyr Lys Leu Tyr G:i.u Ala Asp Phe Val Leu Phe Gly Tyr
395. 90C? 905
Pro Lys Pro Glu Asn Leu Leu Arg Asp
910
<210=> 967
<211> 1071
<212:> DNA
<213> Ilomo sapiens
<400> 467
tcgggccaga attcggcacg aggc:ggcacg agggcgacgg cctcacgggg 50
ctttggaggt gaaagaggcc cagaatagag agagagagag accgacgtac I00
acgggatggc tacgggaacg cgcaatgccg ggaaggtggt ggtcgtgacc 150
gggggcgggc gcggcatcgg agctgggatc gtgcgcgcct tcgtgaac:ag 200
cggggcccga gtggttatct gcgac:aagga tgagtctggg ggccgggccc 250
tggagcagga gctccctgga gctgtcttta tcctctgtga tgtgactcag 300
gaagatgatg tgaagaccct ggt:ttctgag accatccgcc gatttggccg 350
cctggattgt gttgtcaaca acgc~gge:ca ccacc:caccc ccacagaggc 900
ctgaggagac ctctgcccag ggattccacc agctgctgga gctgaaccta 450
ctggggacgt acaccttgac caagctcc~cc ca cccctacc tgcggaagag 500
tcaagggaat gtcatcaaca tctccagc:ct ggtgggggca atcggcc.agg 550
cccaggcagt tccctatgtg gccaccaagg gggcagtaac agccsatgacc 600
aaagctttgg ccctggatga aagtccat:at ggtgtccgag t=caactgtat 650
ctccccagga aacatctgga ccccgct~-~tg ggaggagctg gcagccttaa 700
tgccagaccr_ tagggccaca atccgaga gg gcatgctggc ccagccactg 75U
ggccgcatgg gccagcccgc tgaggtcggg gctgcggcag tgttcctggc 800
ctccgaagcc aacttctgca cc~ggcatt.ga actgctcgtg acggggggtg 850
cagagctggg gtacgggtgc aaggccagtc ggagcacccc cgtggacgcc 900
cccgatatcc cttcctgatt t!-tctcattt c:tactt.gggg cccccttcct 950
aggactctcc caccccaaac tccaacctgt atcagatgca gcccccaagc 1000
ccttagactc taagcccagt tagcaaggtg ccgggt.cacc ctgcaggttc 1050
ccotaaaaac gatttgcagc c 1071
<2I0> 468
<211> 270
<212> PRT
310

CA 02421388 2003-03-25
<213> Homo Sapiens
<400> 468
Met Ala Thr Gly Thr Arg Tyr Ala Gly :Lys Va1 Val Val Val Thr
1 ' 10 15
Gly Gly Gly Arg Gly Ile G:l.y Ala Gl.y Ile Val Arg Ala Pte Val
20 2_'> 30
Asn Ser Gly Ala Arg Val Val Ile Cys Asp Lys Asp Glu Ser Gly
35 4(i 45
Gly Arg Ala Leu Glu Gln G.Lu Leu Pro G1~,~ Ala Val Phe Ile Leu
0 5'~ 6 0
Cys Asp Vai Thr Gln Glu Asp AsF% Val Lys Thr Leu Va1 Ser Glu
65 70 75
Thr Ile Arg Arg Phe Gly Arg Lea Asp Cys Val Val Asn Asn Ala
80 85 90
Gly His His Pro Pro Pro Gln Arg Pro Glu Glu Thr 5er Ala Gln
95 100 105
Gly Phe Arg Gln Leu Leu Glu Leu Asrn Leu Leu Gly Thr Tyr Thr
110 115 120
Leu Thr Lys Leu Ala heu Pro Tyr Let-: Arg Lys Ser Gl.n Gly Asn
125 130 135
Val Ile Asn Ile Ser Ser Leu Va.1 Gly Ala Ile Gly Gln Ala Gln
140 195 150
Ala Val Pro Tyr Val Ala '1'h_= Lys Gly Ala Val Thr Ala Met Thr
155 160 165
Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly Val Arg Val Asn
1;0 1'.?5 180
Cys Ile Ser Pro G1y Asn Ile Trp Thr Pro Leu Trp G1u G1u Leu
185 1!~0 195
Ala Ala Leu Met Pro Asp Fro Arg A1a Thr Ile Arg Glu Gly Met
200 205 210
Teu Ala Gln Pro Leu Gly Arg Met Gly GLn Prc Ala Glu Val Gly
215 22C 225
Ala Ala Ala Val Phe Leu Ala Ser Glu Al.a Asn Phe Cys Thr Gly
230 2:35 290
Ile Glu Leu Leu Val Thr Gly GLy Ala Glu Leu Gly Tyr Gly Cys
245 250 255
Lys Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser
260 265 270
<21U> 969
<211> 687
<212> DNA
<213> Homo sapiens
<400> 469
3 ?.1

CA 02421388 2003-03-25
aggcgggcag cagctgcagg ctgaccttac: agctt:Igcgg aatggactgg 50
cctcacaacc tgctgtttct tcttaccai.t: tc:<:atcttcc tggggctggg 100
ccagcccagg agccccaaaa gcaagaggaa ggggcaaggg cggcctgggc 150
ccctggcccc tggccctcac caggtgccac tggac~~tggt gtcac:ggatg 200
aaaccgtatg cccgcatgga ggagtatgag aggaacatcg aggagatggt 250
ggcccagctg aggaacagct cagagctggc ccagagaaag tgtgaggtca 300
acttgcagct gtggatgtcc aacaagagga gc<;tgtctcc ctggggctac 350
agcatcaacc acgaccccag ccgtatcccc gtggacctgc cggaggcacg 400
gtgcctgtgt ctgggctgtg tgaacccctt <:accatgcag gaggaccgca 950
gcatggtgag cgtgccggtg ttc:agccagg ttcctgtgcg ccgccgccac 500
tgcccgccac cgccc:cgcac agggcctt.gc cgccagcgcg cagtcatgga 550
gaccatcgct gtgggctgca cctgc atc:tt. ctgaatcacc t.ggcccagaa 600
gccaggccag cagcccgaga ccatcctoct tgcac:ctttg tgcc:aagaaa 650
ggcctatgaa aagtaaacac tg,~cttttga aagcaag 68~J
<210> 970
<21i> 180
<212> PRT
<213> Homo sapiens
<900> 470
Met Asp Trp Pro His Asn Leu Leu Ptie Lc~u Leu Thr Ile Ser Ile
1 5 10 15
Phe Leu Gly Leu Gly Gln Pro Arg Seer Pro Lys Ser Lys Arg Lys
20 25 30
Gly Gln Gly Arg Pro Gly Pro Leu ALa Pro Gly Pro His Gln Val
35 40 45
Pro Leu Asp Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu
50 55 60
Glu Tyr Glu Arg Asn Ile Glu Glu Met Val. Ala Gln Leu Arg Asn
65 70 75
Ser Ser Glu heu Ala Gin Arg i,ys Cys Glu Val Asn Leu Gln Leu
80 85 90
Trp Met Ser Asn Lys Arg Ser Leu Ser Fro Trp Gly Tyr Ser Ile
95 100 105
Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu Ala Arg
110 715 120
Cys Leu Cys Leu C:ly Cys Val Jsn Pro Phe Thr Met: Gln Glu Asp
125 7.30 135
Arg Ser Met Val Ser Val Pro Val Fhe Ser Gln Val Pro Val Arg
140 :L45 150
312

CA 02421388 2003-03-25
Arg Arg Leu Cys Pro Fro Pro Prc~ Ara, Thr Gly Fro C:ys Arg Gln
15s l6C:c 165
Arg Ala Val Met Giu Thr Tle A1<Val Gly Cys 'rhr Cys Ile Phe
170 175 180
<210> 971
<211> 2368
<212=> DNA
<213> Homo Sapiens
<400> 971
gcgccgccag gcgtaggcgg ggtggccctt gcgtctcccg cttccttgaa 50
aaacccggcg ggcgagcgag gctgcgggcc ggccgctgcc cttccccaca 100
ctccccgccg agaagcctcg ctcggcgccc aacatggcgg gtgggcgctg 150
cggcccgcag ctaacggcgc tcc::a ggccgc ctggatcgcg gctgtggc:gg 200
cgacggcagg ccccgaggag gccgc:gctgc cgc:cggagca gagccgggtc 250
cagcccatga ccgcctccaa ctqgacgctg gtgatggagg gcgagtggat 300
gctgaaattt tacgccccat ggtgt:ccatc ctgccagcag actgattcag 350
aatgggaggc ttttgcaaag aatggtgaaa tactt.cagat cagtgtgggg 900
aaggtagatg tcattcaaga accaggtttg agtggccgca tctttgtcac 450
cactctccca gcattttttc atc~caaactga tgggatattc cgccgttatc 500
gtggcccagg aatcttcgaa gacctgcaga attateatctt agagaagaaa 550
tggcaatc:aa tcgagcca ct gactggctgg aaat<:cccag cttctctaac 600
gatgtctgga atggctggtc tttttagcat ctct<lgcaag atatggcat~c 650
ttcacaacta tt.tcacagtg actcttggaa ttcc~:_gcttg gtgttcttat 700
gtgtttttcg tcatagccac ctt:ggttrt:t ggccttttta t=gggtctggt 750
cttggtggta atatcagaat gtttctargt gcca~~:ttcca aggcatttat 800
ctgagcgttc tgagcagaat cggagatcJag aggaggctca 1=agagctgaa 850
cagttgcagg atgcggagga ggaaaaagat gattcaaatg aagaagaaaa 900
caaagacagc cttgtagatg atgaagaaga gaaagaagat cttggcgatg 950
aggatgaagc agaggaagaa gagqaggagg ac:aacttggc tgctggt.gtg 1000
gatgaggaga gaagtgaggc caatgatcag gggcccccag gagaggacgg 1050
tgtgacccgg gaggaagtag agcctgagga ggctgaagaa ggcatct..ctg 1100
agcaaccctg cccagctgac acagaggtgg t:ggaagactc cttgaggcag 1150
cgtaaaagtc agcatgctga caagggactg tagatttaat gatgcgtttt 1200
caagaataca caccaaaaca atatgtcagc ttcc:ctttgg cctgcagttt 1250
3:3

CA 02421388 2003-03-25
gtaccaaatc r:ttaattttt cctgaatgag caagcttctc ttaaaagatg 1300
ctctctagtc atttggtctc atggcagtaa gcc:tcatgta tactaaggag 1350
agtcttccag gtgtgacaat caggat:atag aaaaacaaac gtagtgttgg 1400
gatctgtttg gagactggga tggctaacaag ttc:atttact taggggtcaig 1950
agagtctcga ccagaggagg ccat.tcccag tcctaatcag c:accttccag 1500
agacaaggct gcaggccctg tgaaatgaaa gccaagcagg agccttggct 1550
cctgagcatc cccaaagtgt aacgtagaag ccttgc:atcc t:tttcttgtg 1600
taaagtattt atttttgtca aattgcagra aacatcaggc accac:agtgc 1650
atgaaaaatc tttcacagct agaaattgaa agggccttgg gtatagagag 1700
cagctcagaa gtcatcccag ccct.ctga~:~t ctcctgtgct atgtrttatt 1750
tcttaccttt aatttttc:ca gcatttcca~c catgggcatt cagget.ctcc 1800
acactcttca ctattatctc ttggtcagag gactccaata acagccaggt 1850
ttacatgaac tgtgtttgtt catt:ctgar:c taaggggttt agataatcag 1900
taaccataac ccctgaagct gtgactgcc:a aac:atctcaa atgaaatgtt 1950
gtggccatca gagactcaaa aggaagtaag gattttacaa gacagattaa 2000
aaaaaaattg ttttgtccaa aatatagttg ttgttgattt ttttttaagt 2050
tttctaagca atatttttca agc:cagaagt cctctaagtc ttgccagt_ac 2100
aaggtagtct tgt.gaagaaa agt.tgaatac tgttttattt tcatctcaag 2150
gggttccctg ggtcttgaac tactttaata ataaotaaaa aaccacttct 2200
gattttcctt cagtgatgtg ct.vttggtga aagaattaat gaactccagt 2250
acctgaaagt gaaagatttg attttgtttc catct:tctgt aatcttccaa 2300
agaattatat ctttgtaaat ct:a caatac tcaatctact gtaagtaccc 2350
agggaggcta atttcttt 2368
<210> 472
<211> 34g
<212> PRT
<213> Homo sapiens
<900> 472
Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala Leu Leu Ala
1 5 10 15
Ala Trp Ile Ala Ala Val Ala Ala Thr Ala Gly Pro Glu Glu Ala
20 '25 30
Ala Leu Pro Pro Glu Gln Ser Arg Va.L Gln Pro Met Thr Ala Ser
35 90 45
Asn Trp Thr Leu Val Met Glu Gay c;l.u T'rp Met. Leu Lys Phe Tyr
50 55 60
37.4

CA 02421388 2003-03-25
Ala Pro Trp ~~ys Pro Ser Cys Gln Gln Thr Asp :.,er Glu Trp Glu
65 ~0 75
Ala Phe Ala Lys Asn Gly G.W Ile Leu Gln I1e Ser Val C~ly Lys
80 85 90
Val Asp Val Ile Gln Gl.u Pro Gly Leu Ser Gly Arg Phe Phe Val
95 100 105
Thr Thr Leu Fro Ala Phe Phe Hi:v Ala Lys Asp Gl.y Ile Phe Arg
110 115 120
Arg Tyr Arc_ Gly Pro Gly I.Le Phe Glu Asp Leu Gln Asn T yr Ile
130 135
125
Leu Glu L~ys Lys Trp Gln Ser Va-~ Glu Pro Leu 'Ihr Gly Trp Lys
140 145 150
5er Pro Ala Ser heu Thr Met Ser G.ly Met Ala Gly Leu Phe Ser
155 160 165
Ile Ser Gly Lys Ile Trp His Le,. His Assn Tyr Fhe Thr Val Thr
170 175 180
Leu Gly Ile Pro Ala Trp C:ys Ser Tyr Val Fhe Phe Val Ile Ala
195 190 195
Thr Leu Va1 Phe Gly Leu Phe Met G1y Leu Val Leu Val Val Ile
2_00 205 210
Ser Glu Cys Phe Tyr Val Pro Leu Fro Arg His Leu Ser Glu Arg
215 220 225
Ser Glu Gln Asn Arg Arg Ser Glu Glu Ala His Arg Ala Glu Gln
230 2.~5 240
Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn Glu Glu Glu
295 250 255
Asn Lys Asp Ser Leu Val Asp Asp Glu Glu Glu Lys Glu Asp Leu
260 265 270
Gly Asp Glu Asp Glu Ala Glu G.iu Glu G:L.u Glu Glu Asp Asn Leu
2?5 280 285
Ala Ala Gly Val Asp Glu Glu Arg Ser Glu Ala Asn Asp Gln Gly
290 295 300
Pro Pro Gly Glu Asp Gly Val Thr Arg Glu Glu Val Glu Pro Glu
305 370 315
Glu Ala Glu Glu G1y Ile Ser GLu Gln Pro Cys Fro Ala Asp Thr
320 325 330
Glu Val Val Glu Asp Ser Leu Arg Gln Arg Lys Ser Gln His Ala
335 390 345
Asp Lys Gly Leu
<210> 973
<211> 29
315

CA 02421388 2003-03-25
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
v 222> 1-2.4
~'223> Artificial Sequence
<400> 973
gtccagccca tgaccgcctc caac 29
<210> 974
<211> 24
<212> DNA
<213> Artificial
t2LO>
<221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 474
ctctcatcat ccacaccagc agcy 24
<210> 975
<211> 44
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-94
<223> Artificial Sequence
<400> 975
gtggatgctg aaattttacg cc<:catggtg tccatc.ctgc cagc 94
<210> 476
<211> 2478
<212> DNA
<:213> Homo sapiens
<400> 476
atctggttga actacttaag cttaattt:gt taaa<:tccgg taagtaccta 50
gcccacatga tttgactcag agattctcett ttgt<ecacag acagtcatct 100
caggggcaga aagaaaagag ctcccaaatg ctat<3tctat t.caggggctc 150
tcaagaacaa tggaatatca tc<agattta gaaaa tttgg atgaagatgg 200
atatactcaa ttacacttcg actctcaaag coat,~ccagg aatagctgttg 250
tttcagagaa aggatcgtgt gctgcat;:tc ctccttggcg cctcatt.gct 300
gtaattttgg gaatcctatg cttggtaata ctggtgatag ctgtggtcct 350
gggtaccatg ggggttcttt cc<3gcccttg tcctcctaat tggattatat 900
atgagaagag ctgt.tatcta ttcagcatgt cactaaattc ctgggatgga 450
agtaaaagac aatgctggca actgggctct aatctcctaa agatagacag 500
3i6

CA 02421388 2003-03-25
ctcaaatgaa ttgggattta tagtaaaaca agtgtcttcc caacctgata 550
attcattttg gataggcctt tctcggcccc agactgaggt accatggctc 600
tgggaggatg gatcaacatt ctcttctaac ttatttcaga t:cagaaccac 650
agctacccaa gaaaacccat ctccaaattg tgtaatggatt cacgtgtc<3g 700
tcatttatga ccaaci:gtgt agtgtgccct catatagt:at: tt.gtgagaag 750
aagttttcaa tgtaagagga agggtggaqa aggagagaga aatatgtgag 800
gtagtaagga ggacagaaaa cagaacagr~a aagagtaaca gctgaggtca 850
agataaatgc agaaaatgtt tagagagctt ggccaactgt aatcttaacc 90C
aagaaattga agggagaggc tgtgatttc_-t gt.atttgtcg ac:ctacaggt 950
aggctagtat tatttttcta gttagtagat c:ccaagacat ggaatcaggg 1000
cagccaagct tgagttttta ttttttattt att:tattttt ttgagatagg 1050
gtctcacttt gttacccagg ctggagtgc.a gtggcacaat ctcgactcac 1100
tgcagctatc tctcgcctca gccccacaag ta<~ctgggac tacaggtgca 1150
tgccaccatg ccaggctaat ttttggtgtt ttttgtagag actgggtt.tt 1200
gccatgttga ccaagctggt ctctaactc c tgggcttaag tgatctgccc 1250
gccttggcct cccaaagtgc tgggattaca gatgtgagcc accacacctg 1300
gccccaagct tgaattttca ttcagccatt gacttggcat ttaccttggg 1350
taagccataa gcgaatctta atttctgc;ct c:t:atc:agagt tgtttcatgc 1400
tcaacaatgc cattgaagtg cacggtgtgt tgccacgatt tgaccctcaa 1450
cttctagcag t:atatcagt.t atgaactgag ggtgaaatat: atttctgaat 1500
agctaaatga agaaatggga aaaaatcttc acca<.~agtca gagcaatttt 1550
attattttca tcagtatgat cataattatg attarcatct t:agtaaaaag 1600
caggaactcc tactttttct tt.atcaatta aatagctcag agagtacatc 1650
tgccatatct ctaatagaat cttttttttt tttttttttt tttgagacag 1700
agtttcgctc ttgttgccca ggctggagtg c:aacggc:acg atctcggctc 1750
accgcaacct ccgccccctg ggtt.caagca attctcctgc ctcagcctcc 1800
caagtagctg ggattacagt caggcaccac c<scacccggc: taattttgta 1$50
tttttttagt agagacaggg tttctccatg tcggtcaggg tagtcccgaa 1900
ctcctgacct caagtgatct gc:ctgcctcg gcctcccaag tgctgggatt 1950
acaggcgtga gccactgcac cc:agcctaga atcttgtata atatgtaatt 2000
gtagggaaac tgctctcata gga<iagtttt c:tgcatttta aatacaaaaa 2050
tacataaaaa tacataaaat ct=gatgatga atat:aaaaaa gtaaccaacc 2100
3 ~~. 7

CA 02421388 2003-03-25
tcattggaac aagtat.taac attttggaat atgttttatt agttttgtga 2150
tgtactgttt tacaat,tttt accaatttttt tcagtaatta cagtaaaatg 2200
gtattattgg aatgaaacta tati_tcctoa tgtgct.gatt tgtcttattt 2250
ttttcatact ttcccactgg tgctattttt atttc<:aatg gatatttctg 2300
tattactagg gaggcatt.ta cagtcctcra atgttgatta atatgtgaaa 2350
agaaattgta ccaattttac taaattatcc agtttaaaat ggatgatttt 2400
atgttatgtg gatttcattt caataaaaaa aaactcttat caaaaaaaaa 2450
aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2478
<210> 477
<211> 201
<212> PRT
<213> Homo Sapiens
<400> 477
Met Gl.u Tyr His Pro Asp Leu G1u Asn Leu Asp Glu Asp Gly Tyr
1 5 10 15
Thr Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val
20 25 30
Val Ser Glu Lys Gly Ser c;yS Ala Ala Ser Pro Pro Trp Arg Leu
35 90 95
Ile Ala Val Ile Leu Gly lle Leu Cys Leu Val Ile Leu Val Ile
5'0 55 60
Ala Val Val Leu Gly Thr Met G::y Val Leu Ser 5er Pro Cys Pro
65 ~'0 75
Pro Asn Trp Ile Ile Tyr i_lu Lys Ser Cvs Tyr Leu Phe Ser Met
80 f35 90
Ser Leu Asn Ser Trp Asp Gly Seer Lys A:_g Gln Cys Trp Gln Leu
95 100 105
Gly Ser Asn Leu Leu Lys Ile Asp Ser Ser Asn Glu Leu Gly Phe
110 115 120
Ile Val Lys Gln Val Ser Ser G1n Pro Asp Asn Ser Phe Trp Ile
125 130 135
Gly Leu Ser Arg Pro Gln Thr Glu Val. Pro Trp Leu Trp Glu Asp
140 145 150
Gly Ser Thr Phe Ser Ser ASn Leu Phe Gln Ile Arg Thr Thr Ala
155 160 165
Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His Val Ser
17C 175 180
Val Ile Tyr Asp Gln Leu Cys Ser Val Fro Ser Tyr Ser Ile Cys
185 190 195
Glu Lys Lys Phe Ser Met
3 _8

CA 02421388 2003-03-25
200
<210> 478
<211> 27
<212> DNA
<213> Artificial
<220>
<221> Artificial :iequence
<2 22> 1-27
<223> Artificial Sequence
<400> 478
gtccacagac agtcatctca ggagcag ;'.
<210> 479
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<900> 479
acaagtgtct tcccaacctg 20
<210> 480
<211> G4
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<:222> 1-24
<:223> Artificial Sequence
<:400> 980
atcctcccaq agccatggt.a cctc 24
~~210> 481
~:211> 51
<?_ 12 > DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-51
<223> Artificial Sequence
<900> 981
ccaaggatag ct:gttgtttc agagaaagga tcgtgtgctg catctcctcc 50
t 51
<210> 482
<211> 3819
<212> DNA
<213> Homo sapiens
<900> 482
ggaaggggag gagcaggcca cacaggcaca ggcc:ggtgaq ggacctgccc 50
319

CA 02421388 2003-03-25
agacctggag ggtctcgctc tgtcacacag gctggagt.gc agtggtgtga 100
tcttggctca tcgtaacctc cacctc:ccgg gttcaagtga ttctcatgcc 150
tcagcctccc gagtagctgg gatt.acaggt ggtgacttcc aagagtgac:t 200
ccgtcggagg aaaatgactc cccagtcgct gctgcagacg acactgttc:c 250
tgctgagtct gctcttcctg gtcca<~ggtg cccaccigcag gggccacag g 300
gaagactttc gcttctgcag ccac3cggazzc cagacacaca ggagcagcct 350
ccactacaaa cccacaccag acctgcgca:t ctccat:cgag aactc:cgaag 400
aggccctcac agtccatgcc cctttccct:.g cagccoac;cc tgcttcccga 450
tccttccctg accccagggg cct.ct.accaac ttctgcctct actggaaccg 500
acatgctggg agottacatc: ttctctatgg caagcgtgac tt:cttgctga 550
gtgacaaagc ctctagcctc ctctgcttcc agcac~agga ggagagcctg 600
gctcagggc:c ccccgctgtt agccacttat gtc.acctcct ggtggagccc 650
tcagaacatc agcctgccca gtgccgccag ctt:caccttc tccttccaca 700
gtcctcccca cacggccgct cacaatgcct cggtggacat gtgcgagctc 750
aaaagggacc tccagctgct cagccagttc ctgaagcatc cccagaaggc 800
ctcaaggagg ccctcggctg ccc:ccgccag ccagcagttg cagagcctgg 850
agtcgaaact gacctctgtg agatt_catgg gggac:atggt gtccttcgag 900
gaggaccgga tcaacgccac ggtgtggaag ctccagccca cagccggcct 950
ccaggacctg cacatccact cccggcagga ggaggagcag agcgaga=ca 1000
tggagtactc ggtgctgctg cctcgaac;ac tcttc;cagag gacgaaaggc 1050
cggagcgggg aggctgagaa gag actcr;tc ctggt:ggact tcagcagcca 1100
agccctgttc caggacaaga attccagc:c;a agtcctgggt gagaaggtct 1150
tggggattgt; g gtacagaac accaaag;.ag ccaacctcac ggagcccgtg 1200
gtgctcac;tt tccagcacca gc.tacag%;cg aagaatgtga c:tctgcaatg 1250
tgtgttctgg gttgaagacc ccacattgag cagcc:cgggg cattggagca 1300
gtgctgggtg tgagaccgtc aggagagaaa ccca.aacatc ctgcttctgc 1350
aaccacttga cctactttgc agtgctgatg gtctcctcgg tggaggtgga 1400
cgccgtgcac aagcactacc tgagcctcct ctcctacgtg ggctgtctcg 1450
tctctgccct ggcctgcctt gt.caccattg ccgcctacct ctgctccagg 1500
gtgcccctgc cgtgcaggag gaaacctcgg gactacacca tcaaggtgca 1550
catgaacctg ctgctggccg tc.ttcctgct ggacacgagc ttcctgca ca 1600
320

CA 02421388 2003-03-25
gcgagccggt ggccctgaca ggctctgagg ctggctgccg agccagtgcc 1650
atcttcctgc acttctccct gctcacctgc ctti=cctgga tgggcctcqa 1700
ggggtacaac ctctaccgac tcgtggtgga ggt.ctttggc acctatgtcc 1750
ctggctacct actc:aagctg agcgc<:atag gctggggct.t ccccatcttt 1800
ctggtgacgc tggtggccct ggtggatgtg gacaactotg gccccatcat 1850
cttggctgtg cataggactc cagagggcgt catctaccct tccatgtgct 1900
ggatccggga ctccctggtc agcr_a~~atca ccaacctggg cctcttcagc: 1950
ctggtgtttc tgttcaacat ggc~~atgcta gccaccatgg tggtgcagat. 2000
cctgcggctg cgcccccaca cccaaaagrg gtcacatgtg ctgacactgc 2050
tgggcctcag cctggtcctt ggc~ctgccct gggccttgat cttcttctcc 2100
tttgct.tct=g gcaccttcca gcttgtcga~c ctcta~~cttt tcagcatcat 2150
cacctccttc caaggcttcc tcatcttcat ctggtactgg tccatgcggc 2200
tgcaggcccg gggtggcccc tcccctctga agagcaact.c agacagcgcc 2250
aggctcccca tcagctcggg cac~cacctcg tccagccgca tctaggcctc 2300
cagcccacct gcccatgtga tgaagcagag atgcggcctc gtcgcacact 2350
gcctgtggcc cccgagccag gcc:cagcccc aggccagtca gccgcagact 2900
ttggaaagcc caacgaccat ggagagatgg gccgttgcca tggtggac:gg 2450
actcccgggc tgggcttttg aattggccr_t ggggactact cggctctc;ac 2500
tcagctccca cgggactcag aagtc~cgccg ccatgctgcc tagggtac~tg 2550
tccccacatc tgtcccaacc cagctggagg cctggtc.tct ccttacaacc 2600
cctgggccca gccctcattg ctgggggc:ca ggcct:tggat c.ttgagggtc 2650
tggcacatcc t:taatcctgt gcccctgc:ct gggac:agaaa tgtggctcca 2700
gttgctctgt. ctctcgtggt ca~,cctga:~gg gcaci=ctgca tcctctgtca 2750
ttttaacca c aggtggcac:c cagggcgaat ggggc:ccagg gcagaccttc 2800
agggccagag ccctggcgga ggagaggc:cc tttg~~cagga gcacagcagc 2850
agctcgccta cctct.gagcc caggccccct ccctccctca gccccccagt 2900
cctccctcca tcttccctgg ggttctcctc ct:ctcccagg gcctccttgc 2950
tccttcgttc acagctgggg gtccccgatt ccaatgctgt tttttgggga 3000
gtggtttcca ggagctgcct ggtc~tctgct gtaaatgttt gtctactgca 3050
caagcctcgg cctgccc:ctg agccaggctc ggtaccgatg cgtgggctgg 3100
gctaggtccc tctgtccatc tgggcctttg tatgagctgc: attgcccatg 3150
ctcaccctga ccaagcacac gc..ctcagagg ggccctcagc: ctctcct~gaa 3200
321

CA 02421388 2003-03-25
gccctcttgt ggcaaqaact gtgqaccatg ccagtcccgt ctggtttcca 3250
tcccaccact ccaaggactg agactgacct cct:ctggtga cactggccta 3300
gagcctgaca ctctcctaag aggttctctc caagccccca aatagctcc:a 3350
ggcgccctcg gccgcccatc atg<lttaatt ctgtcc:aaca aacacacacg 3900
ggtagattgc tggcctgttg taggtggta:g ggacacagat gaccgacctg 3450
gtcactcctc ctgccaacat tcagtctgc~t atgtgaggcg tgcgtgaagc. 3500
aagaactcct ggagctacag ggacagggaYg ccatc<3tt.cc tgcctgggaa 3550
tcctggaaga cttcctgcag gagtcagccft: tcaatcttga ~:rttgaagat 3600
gggaaggatg ttctttttac gtaccaatt_c: t.tttg-cttt tgatattaaa 3650
aagaagtaca tgttcattgt. agagaatttg gaaactgtag aagagaatca 3700
agaagaaaaa taaaaatcag ctgttgtaat cgcctagcaa aaaaaaaaaa 3750
aaaaaaaaaa aaaaaaaaaa aaaaaaaa<-~a aaaaaaaaaa aaaaaaaaaa 3800
aaaaaaaaaa aaaaaaaaa 3819
<210> 983
<211> 693
<212> PRT
<213> Homo Sapiens
<900> 983
Met Thr Pro Gln Ser Leu Leu G1n 'I'hr Tr.r Leu Phe Leu Leu Ser
1 5 10 75
Leu Leu Phe Leu Val G In Gly Ala Hi.s Gl y Arg Gly His Arg Glu
20 25 30
Asp Phe Arg Phe Cys Ser c~ln Arg Asn Gln Thr His Arg Ser Ser
35 90 95
Leu His Tyr Lys Pro Thr Pro Aap Leu Arg Ile Ser Ile G:Lu Asn
50 .'~5 60
Ser Glu Glu Ala Leu Thr Val Hi.s Ala P:ro Phe Pro Ala Ala His
65 ?0 75
Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe
80 85 90
Cys Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr
95 100 105
Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu heu
110 115 120
Cys Phe Gln His Gln Glu G7_u Ser Leu Ala Gln Gly Pro Pro Leu
125 130 135
Leu Ala Thr Ser Val Thr Ser T'rp Trp Ser Pro Gln Asn I1e Ser
140 195 150
322

CA 02421388 2003-03-25
Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser Phe His Ser f'ro Pro
155 160 165
His Thr Ala Ala His Asn A7.a Ser Val Asp Met Cys Glu heu Lys
170 175 180
Arg Asp Leu Gln Leu Leu Ser Glr: Phe :Leu Lys His F'ro Gln Lys
185 190 195
Ala Ser Arg Arg Prc Ser Ala Ala Pro Ala Ser Gln Gln Leu Gln
200 205 210
Ser Leu Glu Ser Lys Leu Thr Sez: Val Arg Phe Met Gly Asp Met
215 220 225
Val Ser Phe Glu Glu Asp Arg I1<> Asn Ala Thr Val 'I'rp Lys Leu
230 23.'; 290
Gln Pro Thr Ala Gly L~eu Gl.n Asp Leu His Ile His Ser Arg Glr!
295 250 255
Glu G'_u Glu Gl.n Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro
260 26'; 270
Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu
275 280 285
Lys Arg Leu Leu Leu Va1 Asp Phe Ser Ser Gln Al.a Leu Fhe G1n
290 295 300
Asp Lys Asn Ser Ser Gln Va-_ Leu Gly Glu Lys Val Leu Gly Ile
305 310 315
Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val
320 32'5 330
Leu Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Th r Leu Gln
335 340 395
Cys Val Phe Trp Val Glu Asp Pr-o Thr Leu Ser Ser Pro Gly His
350 355 360
Trp Ser Ser Ala Gly Cys Glu Tt~~r Val Arg Arg Glu Thr Gln Thr
365 3'70 375
Ser Cys Phe Cys Asn His Leu Ttor Tyr Phe Ala Val Leu Met Ual
380 3.35 390
Ser Ser Vai Glu Val Asp Ala Val Hip; Lys His Tyr Leu Ser Leu
395 900 905
Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu Ala Cys Leu Val
910 915 420
Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu Pro Cys Arg
925 930 435
Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val. His Met Asn Leu Leu
940 995 450
Leu Ala Val Phe Leu Leu Asp T'hr Ser Phe Leu Leu Ser Glu Pro
455 960 465
3a?3

CA 02421388 2003-03-25
Val Ala Leu Thr Gly Ser G1u Ala Gly C:ys Arg AIa Ser AIa Ile
970 975 980
Fhe Leu His Phe Ser Leu Leu Thr Cys i~eu Ser Trp Met c;ly Leu
985 990 495
Clu Gl.y Tyr Asn heu Tyr Arg Leu Val Val Glu Val Phe (~ly Thr
500 50'. 510
Tyr Va1 Pro Gly Tyr Leu Leu Lye. Leu Ser Ala Met Gly T rp Gly
51 ' 52() 525
Phe Fro Ile Phe Leu Val T'hr Leu Val Ala Leu Val Asp Vai Asp
530 535 590
Asn Tyr Gly Pro Ile Ile Leu A1<: Val His Arg TYrr Pro Glu Gly
595 550 555
Val Ile Tyr Pro Ser Met C'ys Trx:~ Ile Ar~a Asp Ser Leu Val Ser
560 56~ 570
Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe Leu Phe Asn
575 580 585
Met AIa Met Leu Ala Thr Met Val Val G:Ln Ile Leu Arg Leu Arg
590 595 600
Pro His Thr Gln Lys Trp Ser Hi.s Va.l Leu Thr Leu Leu Gly Leu
605 610 615
Ser Leu Va1 Leu Gly Leu l'ro 'T'rp Ala Leu I l a Phe Pt:e Ser Phe
620 625 630
Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile
635 690 645
I1e Thr Ser Phe Gln Gly PhE= LEeu IIe Phe Ile Trp Tyr Trp Ser
650 655 660
Met Arg Leu Gln Aia Arg t.~ly G;iy Pro Ser Pro Leu Lys Ser Asn
665 6'~0 675
Ser Asp Ser Ala Arg Leu Pro Ile Ser Seer Gly Ser Thr Ser Ser
680 685 690
Ser Arg Ile
<210> 484
<211> 516
<212> DNA
<213> Homo sapiens
<220>
<221> unsure
<222> 68, 70, 89, 197
<223> unknown base
<900> 484
tgcctggcct gccttgtcaa caatgccgct tactctgctt ccaggttgcc 50
ctgccttgca gaggaaancn tcgggactac accn.tcaagt; gcacatgaac 100
324

CA 02421388 2003-03-25
ctgctgctgg ccgtcttcct gctggacacg agcttcctgc tcagcgnagc 150
cggtggccct gacaggctct gaaggctggc tgccgagcca gtgccatctt 200
cctgcacttc tcctgctcac ctgc.ctttcc tggatgggcc tcgaggggt.a 25G
caacctctac cgactcgtgg tggaggtctt tggcacctat qtccctggct 300
acctactcaa gctgagcgcc atgggctggg gcttccccat ctttctggtg 350
acgctggtgg ccctggtgga tgtggaca~~c tatggc:ccca tcatcttggc 400
tgtgcatagg actccagagg gcgtc,atcta cccttc:catg tgctggatcc 450
gggactccct ggtcagctac atcaccaaoc tgggcctctt cagcctggtg 500
tttctgttca acatgg 516
<210> 985
<211> 22
<2i2> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-22
<223> Artificial Sequence
<900> 985
ggcattggag cagtgctggg tg 22
<210> 486
<211> 24
<212> DNA
<:213> Artificial
<220>
<:221> Artificial Sequence
<222> 1-24
<223> Artificial Sequence
<900> 486
tggaggccta gatgcggctg gacg 29
<210> 48%
<21.1> 2849
<212> DNA
<21.3> Homo sapiens
<220>
<221> unsure
<222> 2715
<223> unknown base
<400> 48?
cggacgcgtg ggcggacgcg tgggcgga cg cgtgggcgga cgcgtgggct 50
ggttcaggtc caggttttgc tttgatcctt ttcaaaaact ggagacacag 100
aagagggctc taggaaaaag tttt=ggatgg gattatgtgg aaactaccct 150
gcgattctct gctgccagag caggctcggc gcttccaccc cagtgcagcc 200
32 5

CA 02421388 2003-03-25
ttcccctggc ggtggtgaaa gagactcggg agtcgc'vgct tccaaagtgc 250
ccgccgtgag tgagctctca ccccagtcag ccaaatgagc: ctcttcgggc 300
ttctcctgct gacatctgcc ctggccggcc agagacaggg gactcaggcg 350
gaatccaacc tgagtagtaa attc.cagttt tccagcaaca aggaacagaa 400
cggagtacaa gatcctcagc atgagagaat tattacagtg t:ctactaat:g 450
gaagtattca cagcccaagg tttcctcata cttatc:caag aaatacggtc 500
ttggtatgga gattagtagc agtagaggaa aatgtatgga tacaacttac 550
gtttgatgaa agatttgggc ttgaagacr:c agaagatgac ;~tatgcaagt: 600
atgattttgt agaagttgag gaacccagtg atggaa ctat attagggcgc 650
tggtgtggtt ctggtactgt acc:aggaa,~a cagat.ttcta aaggaaatca 700
aattaggata agatttgtat ctgatgaata ttttc~~ttct gaaccagggt 750
tctgcatcca ctacaacatt gtc:atgcc;~c aat:tcacaga agctgtgagt 800
ccttcagtgc tacccccttc agctttgc~:a ctggacctgc ttaataatgc 850
tataactgcc tttagtacct tggaagacct tattcgatat cttgaacc:ag 900
agagatggca gttggactta gaagatctat ataggccaac ttggcaac:tt 950
cttggcaagg cttttgtttt tggaagaaaa tcc~agagtgg tggatctgaa 1000
ccttctaaca gaggaggtaa gattatacag ctgcacacct cgtaactt:ct 1050
cagtgtccat aagggaagaa ctaaagaqaa ccgat.accat tttctggr:ca 1100
ggttgtctcc t:ggttaaacg <ac~tclgtc~gg aactcJtgcct gttgtctcca 1150
caattgcaat gaatgtcaat gtgt~~ccaaag c;aaac~ttact aaaaaatacc 1200
acgaggtcct tcagttgaga ccaaagao cg gtgtcagggg attgcacaaa 1250
tcactcac:cg acgtggccct ggagcac<;at gagg<igtgtg actgtgtgtg 1300
cagagggagc acaggaggat agccgcat:ca ccacc,agcag c:tcttgccca 1350
gagctgtgca gtgcagtggc tgattctatt agagaacgta t:gcgttatct 1900
ccatccttaa tctcagttgt ttgcttcaag gacctttcat cttcaggatt 1450
tacagtgcar_ tctgaaagag gagacataaa acagaattag gagttgtgca 1500
acagctcttt tgagaggagg cctaaaggac aggagaaaag gtcttcaatc 1550
gtggaaagaa aattaaatgt tgtattaaat agatcaccag ctagtttcag 1600
agttaccatg tacgtattcc actagctggg ttctgtattt cagttctttc 1650
gatacggctt agggtaatgt cagt~acagga aaaaaactgt gcaagtgagc 1700
acctgattcc gttgccttgc ttaactctaa agctccatgt. cctgggccta 1750
aaatcgtata aaatctggat tt:tt_tttttt tttt.ttgctc: atattcacat 1800
326

CA 02421388 2003-03-25
atgtaaacc.a gaacattcta tgtactacaa acctggtttt taaaaaggaa 1850
ctatgttgct atgaattaaa cttgtgtcat gctgatagga cagactggat 1900
ttttcatatt tcttattaaa attt=ctgcca tttagoagaa gagaacteac:a 1950
ttcatggttt ggaagagata aacc:tgaaaa gaagagtggc catat.ctt<:a 2000
ctt:tatcgat aagtcagttt attT_gtttc:a ttgtgtacat ttttatattc 2050
tccttttgac attataactg ttggcttttc taatcttgtt aaatatatct 2100
att.tttacca aaggtattta atattctttt ttatgacaac ttagatcaac 2150
tatttttagc ttggtaaatt tttct.aaac:a c;aattcxttat agccagagga 2200
acaaagatga tataaaatat tgttgctctg acaaaaatac atgtatttca 2256
ttctcgtatg gtgctagagt tagattaarc tgcattttaa aaaa<:tgaat 2300
tggaatagaa ttggtaagtt gcaaagac't. r_tt.gaaaata attaaattat 2350
catatcttcc attcctgtta ttggagatga aaataaaaag caacttatga 2900
aagtagacat tcagatccag ccattactaa cctattcctt ttttggggaa 2450
atctgagcct agctcagaaa aac:ataaagc accttgaaaa agacttgaca 2500
gcttcctgat. aaagcgtgct gtgctgtgca gtaggaacac atcctattta 2550
ttgtgatgtt gtggttttat tatcttaaac tctgttccat acacttgtat 2600
aaatacatgg atatttttat gtacagaagt atgtctctt:a accagttcac 2650
ttattgtact ctggcaattt aaaagaaaat c:agtaaaata ttttgctrgt. 2700
aaaatgctta atatngtgcc taggttatgt ggtgactatt. tgaatcaaaa 2750
atgtattgaa tcatc:aaata aaagaatcatg gctattttgg ggagaaaatt 2800
aaaaaaaaaa aaaaaaaaaa aggtttaeXgg ataacagggt aatgcggcc 2849
<210> 988
<211> 395
<212> PRT
<213> Homo sapiens
<400> 988
Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly
1 5 10 15
Gln Arg Gl.n Gly Thr Gln Al.a Glu Ser Asn L~eu Ser Sex Lys Phe
20 25 30
Gln Phe Ser Ser Asn Lys Glu Gin Asn Gly Val Gln Asp Pro Gln
35 90 95
His Glu Arg Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser
50 55~ 60
Pro Arg Phe Pro His Thr Tyr Fro Arg F,sn Thr Val Len Val Trp
65 70 75
32 ?

CA 02421388 2003-03-25
Arg Leu Val Ala Val Glu Glu Asn Val Trp Ile Gln Leu Thr Phe
8C 85 90
Asp Glu Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp Ile C.:ys Lys
95 :00 105
Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp Gly Thr ~7.e Leu
110 115 120
Gly Arg Trp Cys Gly Ser Gly Thr Val Prc Gly Lys Gln ~le Ser
125 130 135
Lys Gly Asn Gln Ile Arg I.ie Arc: Phe Val Ser Asp Glu '"yr Phe
7_40 145 150
Pro Ser Glu Pro Gly Phe Cys Ilc Hip: Tyr Asn .Lle Val Met Pro
155 160 165
Gln Phe Thr Glu Ala Val Ser Pr~~ Ser Val Leu Pro Pro Ser Ala
170 17'=: 180
Leu Pro Leu Asp Leu Leu Asn Asn Ala Ilt~ Thr Al.a Phe Ser Thr
185 190 195
Leu Glu Asp Leu Ile Arg Tyr Le.x Glu Pro Glu Arg Trp Gln Leu
200 205 210
Asp Leu Glu Asp Leu Tyr P.ra, Pr~:~ Thr Trp Gln Leu Leu Gly Lys
215 220 225
Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu
230 235 240
Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe
245 250 255
Ser Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe
260 26w 270
Trp Pro Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala
275 280 285
Cys Cys Leu His Asn Cys Asn Gnu C'ys G).n Cys Val Pro Ser Lys
290 295 300
Val Thr Lys Lys Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr
305 3:10 315
Gly Val Arg Gly Leu His Lys Ser Leu Thr Asp Val Ala lieu Glu
32.0 3:% 5 330
His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser Thr Gly Gly
335 390 395
<210> 489
<211> 21
<212> DNA
<213> Artificial
<220%
<221> Artificial Sequence
<222> 1-21
328

CA 02421388 2003-03-25
<22.3> Artificial Sequence
<400> 989
acttctcagt gtccataagg g 27
<210> 490
<211> 40
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<'Z22> 1-4G
<223> Artificial Sequence
<400> 490
gaactaaaqa gaaccgat=ac cattttctgg c:cagg~tgtc 40
<210> 491
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<900> 991
caccacagcg tttaaccagg 20
<210> 492
<211> 20
<212> DNA
<213> Artificial
<220>
<:221> Artificial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 49~:
acaacaggca cagttcccac 20
<210> 493
<211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> l-21
<223> Artificial Sequence
<400> 993
ggcggaatcc aacctgagta g 21
<210> 494
<211> 20
<212> DNA
<213> Artificial
<220>
329

CA 02421388 2003-03-25
<221> Artifir_ial Sequence
<222> 1-20
<223> Artificial Sequence
<400> 494
gcggctatcc tcctgtgctc 20
<210> 995
<211> 3283
<212> DNA
<27.3> Homo sapiens
<900> 995
cccatctcaa gctgatcttg gcacctctca tgctc~=gctc tcttcaacca 50
gacctctaca ttccattttq gaagaagac~t aaaaatggtg tttccaatgt 100
ggacactgaa gagacaaatt ctt:atccttt ttaac._itaat cctaatttcc 150
aaactccttg gggctagatg gtttcctaaa act:ctgccct gtgatgtcac 200
tctggatgtt ccaaagaacc atgtgatcgt. qgactgcaca gacaagcatt 250
tgacagaaat tcctggaggt attcccacga acaccacgaa cctcaccctc 300
accattaacc acataccaga catctcccca gcgtcctttc acagactgga 350
ccatctggta gagatcgatt tcagatgcaa ctgtgtacct attccact::gg 400
ggtcaaaaaa caacatgtgc atcaagaggc t.gcacattaa accc.agae3gc 450
tttagtggac tcacttattt aaaatccc:tt taco ggatg gaaaccagct 500
actagagata ccgcagggcc t.cccgcctag cttac:agctt ctcagccttg 550
aggccaacaa catcttttcc atcagaaaag agaatctaac agaactggcc 600
aacatagaaa tactctacct gggccaaaaac tgttattatc gaaatccttg 650
ttatgtttca tattcaatag agaaagatgc cttcctaaac ttgacaaagt 700
taaaagtgct ctccctgaaa gataaca,-atg tcacagccgt ccctaca gtt 750
ttgccatcta ctttaacaga actatat_etc taca,scaaca tgattgcaaa 800
aatccaagaa gatgatttta ataacct.~.a~ ccaattacaa attcttgacc 850
taagtggaaa ttgccctcgt tgLtataatg c<:ccatttcc ttgtgcgccg 900
tgtaaaaata attctcccct acagatccct gtaaatgctt ttgatgc:gct 950
gacagaatta aaagttttac gtctacacag t<~actctctt: cagcatgtgc 1000
ccccaagatg gtttaagaac atcaacaaac tccaggaact: ggatctgtcc 1050
caaaacttct tggccaaaga aatt=ggggat gctaaatttc: tgcattttct 1100
ccccagcctc atccaattgg atctgtcttt caattttgaa cttcaggtct 1150
atcgtgcatc tatgaatcta tcacaagcat. tttcatcact: gaaaagcctg 1200
aaaattctgc ggatcagagg atatgtcttt aaagagttga aaagctttaa 1250
330

CA 02421388 2003-03-25
cctctcgcca ttacataatc ttcaaaatct tgaagttctt gatcttggca 1300
ctaactttat aaaaattgct aaci:tcagc:a tgtttaaaca atttaaaaga 1350
ctgaaagtca tagatctttc agtc~aataaa atatcacctt caggagatt:c 1900
aagtgaagtt ggcttctgct caaatgccag aacttctgta caaaagttata 1450
aaccccaggt cctggaacaa tta;-attatt tcagat:atga t=aagtatgca 1500
aggagttgca gattcaaaaa caaagaggca. tcttteatgt ctgttaatga 1550
aagctgctac aagtatgggc agaccttgc~a tctaagtaaa aatagtat,at 1600
tttttgtcaa gtcctetgat tttcagcatc t.ttctttcct caaatgcctg 1650
,satctgtcag gaaatctc:at tagccaaact: cataarggca gtgaattcca 1700
acctttagca gagctgagat att.tggactt ctr.:caacaac cggcttgatt 1750
tactccattc aacagcattt gaagagcttc acaaactgga agttctggat 1800
ataagcagta atagccatta ttttcaatca gaaggaatta ctcatatgct 1850
aaactttacc aagaacctaa aggttctgca gaaactgatg atgaacgaca 1900
atgacatctc ttcctccacc agcaggacca t:ggagagtga gtctcttaga 1950
actctggaat tcagaggaaa tcact_tagat gttttatgga gagaaggtga 2000
taacagatac ttacaattat t.caagaatct gctaaaatta gaggaatt=ag 2050
acatctctaa aaattcccta agtttcttgc ct=tctggagt ttttgatg gt 2100
atgcctccaa atctaaagaa tctctctttq gccaaaaatg ggctcaaatc 2150
tttcagttgg aagaaactcc agtgtctuaa gaacct:ggaa actt:tggacc 2200
tcagccacaa ccaactgacc actgtccc;tg agagatt.atc caactgttcc 2250
agaagcct.ca agaatctgat tcttaagaat aatcaaatca ggagtctgac 2300
gaagtatt.tt ctacaagatg cct.tccagtt gcgaratctg gatctcagct 2350
caaataaaat. ccagatgatc caaaagac:ca gctt.cccaga aaatgtcctc 2400
aacaatctga agatgttgct tttgcatcat. aatcggtttc tgtgcacctg 2450
tgatgctgtg tggtttgtct ggtgggttaa c:c:atacggag gtgactattc 2500
cttacctggc cacagatgtg acttgtgtgg ggccaggagc acacaagggc 2550
caaagtgtga tctccctgga tctgtacacc tgtgagttag atctgacaaa 2600
cctgattctg ttctcacttt cc:atatctgt atctctcttt ctcatggtga 2650
tgatgacagc aagtcacctc tatttctggg atgtgtggta tatttaccat 2700
ttctgtaagg ccaagataaa ggggtatcag cgtctaatat caccagactg 2750
ttgctatgat gctttt.attg tgtatgacac t;aaGgaccca gctgtgaccg 2800
agtgggtttt ggctgagctg gt:ggccaaac tggaagaccc aagagacXaaa 2850
3 z1

CA 02421388 2003-03-25
cattttaatt tatgtctcga ggaaagggac tggttaccag ggcagccagt 2900
tctggaaaac ctttcccaga gcatacagct tagcaaaaag acagtgttt:g 2950
t.gatgacaga caagtatgca aagactgaaa attttGagat a:zgcat.tttac 3000
ttgtcccatc agaggctcat ggatgaaaaa gttgat.gtga ttatcttgat 3050
atttcttgag aagccc:tttc agaagtccaa gttcctccag ctccggaaaa 3100
ggctctgtgg gagttctgtc cttgagtgcxc caaca<iaccc: gcaagctcac 3150
ccatacttct ggcagtgtct. aaagaacgcc ctggccac.ag ac:aatcatgt 3200
ggcctatagt caggtgttca aggaaacg<Xt ctagcccttc tttgcaaaac: 3250
acaactgcca agtttaccaa ggagaggcc;t ggc 3:?83
<210> 496
<211> 1049
<212> PRT
<213> Homo sapiens
<400> 496
Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu
1 5 10 15
Phe Asn Ile I.le Leu Ile ;:>er Lys Leu Leu Gly Ala Arg Trp Phe
20 25 30
Pro Lys Thr Leu Pro Cys hasp Val Thr Leu Asp Val Pro Lys Asn
35 90 95
His Vai Ile Val Asp <.'ys Thr A:~p hys His Leu Thr Glu Ile Pro
50 55 60
Gly Gly Ile Pro Thr Asn Th,r Ttar Asn Leu Thr Leu Thr Lle Asn
E~5 ''0 75
His Ile Pro Asp Ile Ser Pro A:la Ser Phe His Arg Leu Asp His
80 E5 AO
Leu Val Gl.u Ile Asp Phe Arg Cys Asn Cys Val I'ro Ile Pro Leu
95 100 105
Gly Ser Lys Asn Asn Met Cys Ile Lys Arg Leu Gln Ile Lys Pro
1i0 115 720
Arg Ser Phe Ser Gly Leu Thr T;,,~r Leu Lys Ser Leu Tyr Leu Asp
125 130 135
Gly Asn Gln Leu Leu Glu Ile Fro Gln Gly heu Pro Prc: Ser Leu
140 145 150
Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile Fhe Ser Ile Arg Lys
155 160 165
Glu Asn Leu Thr Glu Leu A_a A,sn Ile Clu IlE: Leu Tyr Leu Gly
170 775 180
Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Z'yr Val Ser Tyr Ser Ile
1s5 190 195
332

CA 02421388 2003-03-25
Glu Lys Asp Ala Phe Leu A~.n Leu Thr Lys Leu Lys Val Leu Ser
200 a?05 210
Leu Lys Asp Asn Asr~ Val Thr Ala Val Pro Thr Val Leu Pro Ser
2:L'_v 220 225
Thr Leu Thr Glu Leu Tyr LF>a Tyr Asn Asn Met Ile Ala Lys Ile
230 235 240
Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp
29 ~: 250 255
Leu Ser Gly Asn C;ys Pro Arg Cya Tyr Asn Ala Pro Phe Pro Cys
260 26'.i 270
Ala Pro Cys Lys Asn Asn Ser Prc> Leu Gln Ile Pro Val Asn Ala
275 280 285
Phe Asp Ala Leu Thr Glu heu Ly:> Val Leu Arg Leu His Ser Asn
290 255 300
Ser Leu Gln His Val Pro Pr.o Arg Trp Phe Lys Asn Ile Asn Lys
305 310 315
Leu Gln Glu Leu Asp Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile
320 32 5 330
Gly Asp Ala Lys Phe Leu His Phe Leu Pro Ser Leu Ile Gln Leu
335 340 345
Asp Leu Ser Phe Asn Phe Glu Lea Gln Val Tyr Arg Ala Ser Met
350 355 360
Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser Leu Lys Ile Leu
365 370 375
Arg Ile Arg Gly Tyr Val Phe Lys Glu Leu Lys Ser Phe Asn Leu
380 385 390
Ser Pro Leu Hi.s Asn Leu c~ln A;n heu G7a Val Leu Asp Leu Gly
395 900 405
Thr Asn Phe Ile Lys Ile Ala A:=n Leu Ser Met. Phe Lys Gln Phe
470 9:.5 420
Lys Arg Leu Lys Val :Ile Asp Le:u Ser V<~1 Asn Lys Ile Ser Pro
925 430 435
Ser Gly Asp Ser Ser Glu Val Gay F'he Cys Ser Asn Ala Arg Thr
490 445 450
Ser Val Glu Ser Tyr Giu Pro Gln Val Leu Glu Gln Leu His Tyr
455 460 465
Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys
970 975 480
Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly
485 990 495
Gln Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser
500 50_'. 510
333

CA 02421388 2003-03-25
Ser Asp Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser
515 52C 525
Gly Asn Leu Ile Ser Gln Thr Leu Asn Gly Ser Cilu Phe Gln Pro
530 535 590
Leu Ala Glu Leu Arg Tyr Leu AsF; Phe Ser Asn Asn Arg Leu Asp
545 550 555
Leu Leu His Ser Thr Ala Phe Glu Glu Leu His Lys Leu Glu Val
560 56'. 570
Leu Asp Ile Ser Ser Asn Ser Hip. T,rr Phe Gln Ser Glu Gly Ile
575 580 585
Thr His Met Leu Asn Phe Thr Ly;: Asn Leu Lys Val Leu Gln Lys
590 59~ 600
Leu Met Met. Asn Asp Asn Asp Ile Ser Ser Ser Thr Ser Arg Thr
605 610 615
Met Glu S'er Glu Ser Leu Arg Thr Leu Glu Phe Arg Gly Asn His
620 625 630
Leu Asp Val Leu Trp Arg Glu Gly Asp Asn Arg Tyr Leu Gln Leu
635 640 645
Phe Lys Asn Leu Leu Lys I~eu Glu G1u Leu Asp Ile Ser Lys Asn
650 655 660
Ser Leu Ser Phe Leu Pro Ser Gly 'Jal Phe Asp Gly Met. Fro Pro
6E5 670 675
Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly L~eu Lys Ser Phe
680 685 690
Ser Trp Lys Lys Leu Gln Cys LE:~u Lys Asn Leu Glu Thr Leu Asp
695 700 705
Leu Ser His Asn Gin Leu Thr Thr Val Pro Glu Arg Leu Ser Asn
710 7'15 720
Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile
725 730 735
Arg Ser Leu Thr Lys Tyr I'he Leu Gln Asp Ala Phe Glr: Leu Arg
740 745 750
Tyr Leu Asp Leu Ser Ser Asn Lys Ile G.ln Met :Ile Glr: Lys Thr
755 760 765
Ser Phe Pro Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu
770 775 780
His His Asn Arg Phe Leu Cys Thr Cys A.sp Ala Val Trp Phe Val
785 790 795
Trp Trp Val Asn His Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr
800 805 810
Asp Val Thr Cys Val Gly Pro Cly Ala His Lys Gly Gln Ser Val
815 820 825
3:39

CA 02421388 2003-03-25
Ile Ser Leu Asp Leu Tyr Thr Cys Glu Leu Asp heu Thr Asn Leu
830 83'. 890
Ile Leu Fhe Ser Leu Ser Lle Ser Val Ser Leu Phe Leu Met Val
895 85C) 855
Met Met Thr Ala Ser His Leu Tyr Phe Trp Asp Val Trp 'Iyr Ile
860 865 870
Tyr His Phe Cys Lys Ala hys Ile Lys Gly 'I'yr Gln Arg Leu Ile
875 88~) 885
Ser Prc Asp Cys Cys Tyr Asp Ala Phe I1~~ Val Tyr Asp Thr Lys
890 895 90C
Asp Pro Ala Val Thr Glu 'I'rF: Va1 Leu Ala Glu Leu Val Ala Lys
905 91(7 915
Leu Gl.u Asp Pro Arg Glu Ly:; His Phe Asn Leu Cys Leu Glu Glu
920 925 930
Arg Asp Trp Leu Pro Gly C=In Fro Val Leu Glu Asn Leu Ser Gln
935 940 995
Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys
950 95.5 960
Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyx Leu Ser His
965 9;0 975
Gln Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe
980 985 990
Leu Glu Lys Pro Phe Gln L,ys SE>r Lys Phe Leu Gln Leu Arg Lys
995 1000 1005
Arg Leu Cys Gly Ser S'er Val Lr:u Glu T:~p Pro Thr Asn Pro Gln
1010 1015 1020
Ala His Pro Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr
1025 1030 1035
Asp Asn His Val Ala Tyr Ser Gln Val. Phe Lys Glu Thr Val
1090 1045
<210> 99'7
<211> 4199
<212> DNA
<213> Homo sapiens
<400> 997
gggtaccatt ctgcgctgct gcaagttacg gaatgaaaaa ttagaac:aac 50
agaaacatgg aaaacatgt.t cc:ttcagtcg tcaa.tgctga cctgcatttt 100
cctgctaata tctggttcct gtgagttatg cgcc:gaagaa aatttttcta 150
gaagctatcc ttgtgatgag aaaaagcaaa atgactcagt tattgcagag 200
tgcagcaatc gtcgactaca ggaagttccc caaacggtgg gcaaatatgt 250
gacagaacta gacctgtctg ataatttcat cacacacata acgaatgaat 300
3a5

CA 02421388 2003-03-25
catttcaagg gctgcaaaat ctcactaaaa taaatctaaa ccacaacccc 350
aatgtacagc accagaacgg aaatcccggt atacaat::aa atggcttgaa 900
tatcacagac ggggcattcc tcaacctaaa aaacctaagg gagttactgc 950
ttgaagacaa ccagttaccc caaataccct c:tggtttgcc agagtctttg 500
acagaactta gtctaattca aaacaatata tacaacataa ctaaagagg g 550
catttcaaga cttataaact tgaaaaatc:t ctatttggcc tggaactgct 600
attttaacaa agtttgcgag aaaactaac_a t.agaa<aatgg agtatttgaa 650
acgctgacaa atttggagtt gctat.cact_a t:ctttcaatt ctctttcaca 700
cgtgccaccc aaactgccaa gct:ccctas:g caaacttttt ctgagcaaca 750
cccagatcaa atacattagt gaagaagatt tc:aagggatt gataaattta 800
acattactag atttaagcgg gaactgtc;,g aggtgcttca atgccccatt 850
tccatgcgtg ccttgtgatg gtggtgcttc aattaatata gatcgttttg 900
cttttcaaaa cttgacccaa cttcgataac taaacctctc tagcacttcc 950
ctcaggaaga ttaatgctgc ctggtttaaa aatatgcctc atctgaaggt 1000
gctggatctt gaattcaact atttagtggg agaaatagt:c t.ctggggc_at 1050
ttttaacgat gctgccccgc: ttagaaatac ttgacatgtc ttttaacr_at 1100
ataaagggga gttatccaca gcatattaat atttc:cagaa acttctct=aa 1150
acttttgtct ctacgggcat tgc~atttaag aggttatgtg ttcc:aggaac 1.200
tcagagaaga tgatttccag cccctgat;gc agctt:ccaaa ctt:atcgar_t 1250
atcaacttgg gtattaattt. tattaag<:aa atcga tttca aactt.ttcca 1300
aaatttctcc: aatctggaaa ttatttartt gtcagaaaac agaatatcac 1350
cgttggtaaa agatacccgg c:agagtt«tg caaa-agtt.c ctcttttcaa 1900
cgtcatatcc ggaaacgacg ctcaaca<:lat tttgagtttg acccacattc 1450
gaacttttat catttcaccc gtcctttr~at aaagccacaa tgtgctgctt 1500
atggaaaagc cttagattta agcctcaaca gtattttctt cattgggcca 1550
aaccaatttg aaaatcttcc tgacattc~cc tgtttaaatc tgtctgcaaa 1600
tagcaatgct caagtgttaa gtggaacrga attttcagcc attcctc:atg 1650
tcaaatattt ggatttgaca aacaatag ac tagactttga taatgctagt 1700
gctcttactg aatt.gtccga ctt.ggaagtt ctagat:ctca gctataattc 1750
acactatttc agaatagcag gc:gtaacaca tcatctagaa tttattcaaa 1800
atttcacaaa tctaaaagtt ttaaacttga gccacaac:aa catttatact 1850
336

CA 02421388 2003-03-25
ttaacagata agtataacct ggaaagcaag tccctggtag aattagtttt 1900
cagtggcaat cgccttgaca tttt.gtggaa tgatgatgac aacaggtai=a 1950
tctccatttt caaaggtc:tc aagaatctca cacgtc:tgga t:ttatccct=t 2000
aataggctga agcacat<:cc aaatgaag<°a ttcctt.aatt tgccagcgag 2050
tctcactgaa ct.acata~.aa atgataatcat gttaaagttt tttaactgga 2100
cattactcca gcagttt<~ct cgtctcgaqt t.gcttc~actt acgtggaaac 2150
aaactactct ttttaacvga tagcctatut gactt_acat cttccctt~~g 2200
gacactgctg ctgagtcata acaggatttc c:cacct:accc tctggctttc 2250
tttctgaagt cagtagt~tg aagcacctcg attta.3gttc caatctgcta 2300
aaaacaatca acaaatc:~gc act:tgaaa<:t aagaccacca ccaaattatc 2350
tatgttggaa ctacacggaa acc:cctttga atgcacctgt gacattggag 2400
atttccgaag atggatggat gaacatctga atgtcaaaat tcccagaca g 2950
gtagatgtca tttgtgccag tcctggggat caaagaggga agagtattgt 2500
gagtctggag ctaacaactt gtgtttcaga tgtcactgc:a gtgatattat 2550
ttttcttcac gtt.ct.ttatc acwaccatgg ttatgttggc t.gccctgqct 2600
caccatttgt tttactqgga tgi:.ttggttt at=atGtaata tgtgtttagc 2650
taaggtaaaa ggctacaggt ct<attcc,ac at_ccc:aaact ttctat.g<3tg 2700
cttacatttc t:tatgac:acc aaaagatgc;ct ctgtt:actga ctgggtgata 2750
aatgagctgc gctacc<:cct tgaag agagc cgagacaaaa acgt:tctc~ct 2800
ttgtctagag gagaggc~att gg:~accccrgg attggccatc atcgacaacc 2850
tcatgcagag catcaaa:.caa agc:aagaaaaa cagtatttgt to taaccaaa 2900
aaatatgcaa aaagctc:~gaa ctttaaa,::~ca gctt~ttact tggctttgca 2950
gaggctaatg gatgagaaca tggatgt::tat t.atatttatc ca gctggagc 3000
cagtgttaca gcattctcag tatttgaggc tacggcagcg gatctgtaag 3050
agctccatcc tccagt:xgcc tgacaacccg aaggcagaag gcttgttttg 3100
gcaaactctg agaaatgtgg tc:ttgact,:ga aaatgattca cggtataaca 3150
atatgtatgt cgattccatt. aagc;aat3ct aactgacgtt aagtcatgat 3200
ttcgcgccat aataaagatg caaaggaatg acatttctgt attagttatc 3250
tattgctatg taacaaatta tcccaaaact. tagtggtt.ta aaacaacaca 3300
tttgctggcc cacagttttt gagggtcagg agtccaggcc cagcataact 3350
gggtcctctg ctcagggtgt ctca gaqgct gcaa.tgtagg tgttcaccag 3400
agacataggc atcactgggg tcacactcat gtggtt.gttt tctggattca 3450
3 3'7

CA 02421388 2003-03-25
attcctcctg ggctattagc caaaggctat actcatgt.aa clccat.gcgag 3500
cctc:tcccac aaggcagcat gct.tc~atcug agctagcaaa aaagagaggt: 3550
tgctagcaag atgaagt<:ac aat~~ttttgt aatcgaatca aaaaagtgat 3600
atctcatcac tttggccata t.tctatttrt tagaagtaaa c cacaggtcc 3650
caccagctcc atgggagtga cca~~ctca~xt_ ccagggaaaa cagc~gaaga 3700
ccaagatggt gagctctgat tgct=tcagt_t ggtcatcaac tattttccct 3750
tgactgctgt cctgggatgg cctgctat~.t tgatgataga ttgtgaatat 3800
caggaggcag ggatcactgt ggaccatc-:.t agcagttgac ctaacacatc 3850
ttcttttcaa tatctaagaa ctttt.gccac tgtgactaat ggtcctaata 3900
ttaagctgtt gtttatattt atc:atata_c tatggctaca tggttatatt 3950
atgctgtggt tgcgttcggt tttattta~~a gttgctttta caaatatttg 4000
ctgtaacatt tgacttctaa ggttt:agatg ccatttaaga actgagatgg 4050
atagctttta aagcatcttt tacttcttac cattttttaa aagtatgcag 9100
ctaaattcga agcttttggt ctatattatt aattciccatt gctgtaaatc 4150
ttaaaatgaa tgaataaaaa tgt:ttcattt tacaaaaaaa aaaaaaaaa 4199
<210> 498
<211> 1041
<211> PRT
<213> Homo Sapiens
<400> 998
Met Glu Asn Met Phe Leu Gln Seer Ser Met Leu 'Phr Cys Ile Phe
1 5 10 7 5
Leu Leu Iie Ser GLy Ser Cys GLu Leu Cys Ala Glu Glu Asn Phe
20 25 30
Ser Arg Ser Tyr Pro Cys Asp G::u Lys Lys Gln Asn Asp Ser Val
35 90 45
Ile Ala Gl.u Cys Ser Asn Arg A~g Leu Gln Glu Val Prc: Gln Thr
50 55 60
Val Gly Lys I'yr Val Tpr Glu I:eu Asp Leu .'per Asp Asr. Phe Ile
65 70 75
Thr His Ile Thr Ian Glu Ser Fhe Gln Gly Lei:c Gln Asn Leu Thr
80 8'_> 90
Lys Ile Asn Leu Issn His Asn Prc Asn Val Gln His Gln Asn Gly
95 100 105
Asn Fro Gly Iie C~ln Ser Asn C;ly Leu Asn lle Thr Asp Gly Ala
1G 7.15 120
Phe Leu Asn Leu ,ys Asn Leu Arg Glu Leu Leu Leu Glu Asp Asn
.25 i30 135
338

CA 02421388 2003-03-25
Gln Leu Pro Gln Ile, Pro Ser Gly Leu Pr<> Giu Ser Leu Thr Glu
29(i 195 150
Leu Ser Leu Ile Glr: Asn Asn IlE:~ Tyr Asn 11e 'Phr Lys !.1u Gly
15', 160 165
Ile Ser Arg Leu Iie Asn Leu Ly:: Asn Leu Tyr -~,eu Ala '1'rp Asn
17-'0 17!~ 180
Cys Tyr Phe Asn Ly:~ Val Cys Gl~.i Lys Th:r Asn Ile Gl.u Asp Gly
18 ~ 190 195
Val Phe Glu Thr Le.1 Thr Asn Leu Glm Lev Leu Ser Leu Ser Phe
200 205 210
Asn Ser Leu Ser His 11a1 F'ro Pro Lys Leu Pro Ser Ser Leu Arg
215 220 225
Lys Leu Phe Leu Ser Asn Thr Gln ile Lys 'Iyr Ile Ser Glu Glu
230 235 290
Asp Phe Lys Gly Leu Il.e Asn Le..z Thr Leu Leu Asp Leu Ser Gly
245 250 255
Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys
2E.0 265 270
Asp Gly Gly Ala Ser Ile Asn Iie Asp Arg Phe Ala Phe Gln Asn
2''5 280 285
Leu Thr Gln Leu Ax g Tyr Leu As n L,eu Ser Ser T'hr Ser Leu Arg
2~a0 2~)5 300
Lys Ile Asn Ala Aa Trp Phe L;s Asn Met Pro His Leu Lys Val
3 .t5 3:1 0 315
Leu Asp Leu Glu Phe Asn Tyr Lf~u Val G:Ly Glu I:le Val 5er Gly
3:?0 3:'S 330
Ala Phe Leu Thr M~=t :Leu Pro A.cg Leu Glu Ile heu Asp Leu Ser
3 5 340 395
Phe Asn Tyr Ile Lys Gly Ser Tyr Pro G1n His Ile Asn Ile Ser
350 3'i5 360
Arg Asn Phe Ser hys Leu Leu Ser Leu Arg Ala Leu His Leu Arg
365 370 3'75
Gly Tyr Va1 Phe Gln Glu Leu Arg Glu Asp Asp Phe Gln Pro Leu
380 385 390
Met Gln Leu Pro P~sn Leu SE:r T:lr Ile Asn Leu Gly I1e Asn Phe
395 900 405
Ile Lys Gln Ile F~.sp Phe Lys L.eu Phe Gln Asn Phe Ser Asn Leu
S10 915 920
Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val Lys
~25 X30 435
Asp Thr Arg Gln Ser Tyr A.la Asn Ser Ser Ser Phe Gln Arg His
490 445 450
3 :3 9

CA 02421388 2003-03-25
Ile Arg Lys Arg Arc Ser Thr Asp Phe Glu Phe Asp Pro f'is Ser
95' 460 465
A.sn Phe Tyr His Phe Thr Arg Pro Leu Tle hys Pro Gln C.ys Ala
9'7C~ 475 480
Ala Tyr Gly Lys AlaLeu A;~p LeL; Ser Leu Asn Ser Ile Phe Phe
98~ 990 495
Ile Gly Pro Asn Glr~ Phe GLu Asr~ Leu Prc> Asp 1e Ala Cys Leu
500 505 520
Asn Leu Ser Ala Asri Ser Asn Ala Gln Va-~ Leu Ser Gly T hr Glu
51'~ 520 525
Phe Ser Ala Ile Pr~; His Val Ly:: Tyr Leu Asp Leu Thr Asn Asn
530 53'._590
Arg Leu Asp Phe Asp Fa n Ala SeA1a Len Thr Glu Leu Ser Asp
545 55~ 555
Leu Glu Val Leu Asp Leu Ser Tyr Asr~ Ser His Tyr Phe Arg Iie
560 565 570
Ala Gly Va.L Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn
5'75 580 585
Leu Lys Val Leu Asn Leu :ver Hi:; Asn Asn Ile Tyr Thr Leu Thr
5G0 595 600
Asp Lys Tyr Asn Leu Glu Ser Lys Ser Leu Val Glu Leu Val Phe
6C5 610 615
Ser Gly Asn Arg Leu Asp Ile Leu Trp Asn Asp Asp Asp Asn Arg
6a:0 6~ 5 630
Tyr Ile Ser Ile Pte Lys Gly Leu Lys A:;n Leu Thr Arg Leu Asp
6;s5 64:0 695
Leu Ser Leu Asn A.-g Leu Lys His Ile Pno Asn Glu Ala Phe Leu
6'.'.0 6.'i5 660
Asn Leu Pro Ala Ser Leu 'I'thr Giu Leu H=~s Ile Asn Asp Asn Met
6~~5 6'J0 675
L~eu Lys Phe Phe Asn Trp Thr Lf.:~u I:eu G.Ln Gl.n F'he Pro Arg Leu
6r30 685 690
Glu Leu Leu Asp Leu Arg G'ly Ann Lys Leu Leu I'he Leu Thr Asp
695 700 705
Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser
710 715 720
His Asn Arg Ile Ser His Le~u P:.o Ser Gly Phe L,eu Ser Glu Val
725 730 735
Ser Ser Leu Lys His Leu Asp Leu Ser Ser Asn L,eu L,eu Lys Thr
790 745 750
Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser
'.~55 760 765
390

CA 02421388 2003-03-25
Met Leu Glu Leu His Gly Asn Prc: Phe Glu Cys Thr Cys Asp Ile
77C: 775 780
Gly Asp Phe Arg Arc; Trp Met Asp Glu Hip; Leu Asn Val ':~ys Ile
78w, 790 795
Pro Arg Leu Val Asp Val Ile CyAla Ser Fro C~ly Asp Gl.n Arg
800 805 810
Gly Lys Ser Ile Vai Ser Leu Glu Leu Thr Thr Cys Val Ser Asp
81~ 820 825
Val Thr Ala Val Ile Leu Phe Pht~ Phe Th:. Phe Phe Ile Thr Thr
83 7 83:, 890
Met Val Met Leu Ala Ala L,eu A1=3 His Hi.s Leu Phe Tyr Trp Asp
845 850 855
Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr
860 865 870
Arg Ser Leu Ser Thr Ser C:ln Thr Phe Tyr Asp Ala Tyr Ile Ser
875 880 885
Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu
8G0 895 900
Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu
9C~5 910 915
Gys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp
9a 0 925 930
Asn Leu Met Gln SEr Ile Asn Gln Ser Lys Lys Thr Val Phe Val
9.'-,5 940 945
Leu Thr Lys Lys Tyr Ala L~ys SE_r Trp Asn Phe Lys Thr Ala Phe
950 955 960
Tyr Leu Ala Leu Gin Arg Leu Met Asp G:Lu Asn Met Asp Val Ile
965 970 975
Ile Phe Ile Leu Leu Glu Pro V~~l lieu Gln His Ser Gln Tyr Leu
980 935 990
Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro
995 1000 1005
Asp Asn Pro Lys A1a Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn
1010 1015 1020
Val Val Leu Thr C~lu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val
1025 1030 1035
Asp Ser Ile Lys Cln Tyr
1640
<210> 499
<21.1> 20
<212> DNA
<2i3> Artificial,
391

CA 02421388 2003-03-25
<220>
<221> Artificial Se<~uence
<222> 1-2O
<223> Artificial Sequence
<400> 499
taaagaccca gctgtgaccg 20
<21U> 500
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-c:0
<223> Artificial Sequence
<900> 500
atccatgagc ctctgatggg 20
<210> 501
<211> 45
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-45
<22's> Artificial Sequence
<400> 501
atttatgtct cgaggaaagg gactggtt:ac caggclcagcc agttc 45
':210> 502
~:211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21.
<223> Artificial Sequence
<400> 502
gccgagacaa aaacgttctc c 21
<210> 503
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial .equencE>
<222> 1-24
<223> Artificial 6equencc,e
<400> 503
catccatgtt ctcatc-catt agc~~ 2~i
<210> 504
<211> 96
<212> DNA
3q2

CA 02421388 2003-03-25
<213> Artificial.
<220>
<221> Artificial Sequence
<222> 1-96
<223> Artificial Sequence
<900> 504
tcgacaacct catgcagagc atcaacca~:a gcaagaaaac agtatt 9n
<210> 505
<211> 1738
<212> DNA
<213> Homo sapiens
<900> 505
ccaggtccaa ctgcacctcg gttctatc<xa t:tgaattccc cggggatcct 50
ctagagatcc ctcgacctcg acccacgcgt ccgccaagct gg ccctgcac 100
ggctgcaagg gaggctc:ctg tggac:agg::;c aggcaggtgg gcctcaggag 150
gtgcctccag gcggccagtg ggcctgaggc cccagcaagg gctagggtcc 200
atctccagtc ccaggacaca gcagcggcca c:catggccac gcctgggctc 250
cagcagcatc agcagccccc agc;ar_cgggg aggcocaggt ggcccccacc 300
acccggagga gcagctc:ctg cccc~gtccg ggggatgact gattctcct.c 350
cgccaggcca cccagaggag aaggccac:cc cgcct:ggagg cacaggcc;at 900
gaggggctct caggagcltgc tgctgatc,;tg gcttc:tggtg t.tggcagt_gg 450
gcggcacaga gcacgcca ac cggcccgc;cc, gtagggtgtg tgctgtccgg 500
gctcacgggg accctg~:.ctc cgagtcgttc. gtgc<sgcgtg t.gtaccagcc 550
cttcctcacc acctgc~yacg ggcaccgggc Ctgcagcacc taccgaacca 600
tctataggac cgccta~~cgc cgcagcc<:tg ggct~3gcccc tgccaggcct 650
cgctacgcgt gctgccccgg ctggaag<agg accagcgggc t~tcctggggc 700
ctgtggagca gcaatatgcc agccgcc;atg ccggaacgga gggagctgtg 750
tccagcctgg ccgctg:~cgc tgcc:ctgcag gatggcgggg tgacacttgc 800
cagtcagatg tggatgaatg cagtgct<xgg aggggcggct gtccccagcg 850
ctgcatcaac accgc:cggca gttactggtg ccagtgttgg gaggggcaca 900
gcctgtctgc agacggtaca ctctgtgtgc ccaagggagg gccccccagg 950
gtggccccca acccgacagg agtggacagt gcaatgaagg aagaagtgca 1000
gaggctgcag tccagc;gtgg acctgctgga ggagaagctd cagctgc,~tgc 1050
tggccccact gcacaccctg gcctcgc:agg cact:ggagca tgggctcccg 1100
gaccccggca gcctcc: tggt gcactcc:ttc cagc:agctcg gccgcatcga 1150
ctccctgagc gagcac;attt ccttcctgga ggagcagctg gggtcctgct 1200
3~~3

CA 02421388 2003-03-25
cctgcaagaa agactcgtga ctgcc~~agc:g c:cccaggctg gactgagccc 1250
ctcacgccac cctgcagccc ccatgcccct gcccaa catg ctgggggt~Jc 1300
agaagccacc tcggggtgac tgagcggaag gccagc~cagg gc:cttcctcc 1350
tcttcctcct ccccttc:~tc gggaggctc:c c:cagaccctg gcatgggatg 1900
ggctgggatc ttctctgtga atccaccc~:t ggctaccccc accctggcta 1950
ccccaacggc atcccaaggc caggtgggc:c ctcag~~tgag ggaaggtacg 1500
agctccctgc tggagcctgg gacccatggc acaggccagg cagcccggag 1550
gctgggtggg gcctcagtgg gggctgctc~c ctgaccccca gcacaataaa 1660
aatgaaacgt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1650
aaagggcggc cgcgact:cta gagtcgacct gc:agaagctt ggccgccatg 1700
gcccaacttg tttattgcag ctt:at:aatgg ttacaaat. 1738
<210> 506
<211:~ 273
<212PR';
<213> Homo sapiens
<400> 506
Met Arg Gly Ser Gin C~lu Val Le:u Leu Met Trp Leu Leu Val Leu
1 5 =0 15
Ala Val Gly Gly Thr Glu His A-~;a Tyr Arg Pro Gly Arg Arg Val
..?0 25 30
Cys Ala Val Arg Aia His Gly A:-.p Pro Val Ser Glu Ser Phe Val
?5 90 95
Gln Arg Val Tyr GLn Pro Phe Le~u Thr Thr Cys Asp Gly His Arg
'~0 =;5 60
Ala Cys Ser Thr Tyr Arg Thr Ite Tyr Arg Thr Ala Tyr A rg Arg
65 70 75
Ser Pro Gly Leu Ala Pro Ala Aa:g Pro Arg Tyr Al.a Cys Cys Pro
80 85 90
Gly Trp Lys Arg Thr Ser Gly Le a Pro Gly Ala Cys Gly Ala Ala
95 100 105
Ile Cys Gln Pro Pro Cys Arg Asn ugly Gly Ser Cys Vas Gln Pro
720 115 120
Gly Arg Cys Arg C'ys Pro Ala Gly Trp P,rg Gly Asp Thr Cys G1n
125 130 135
Ser Asp Val Asp c:~lu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln
.90 7.95 150
Arg Cys Ile Asn "'hr Ala Gly Ser Tyr Trp Cys Gln Cys Trp Glu
S5 x.60 165
Gly His Ser Leu 'per Ala Asp C-'ly Thr l.;eu Cys Val Pro Lys Gly
3.~ 4

CA 02421388 2003-03-25
17C 175 180
Gly Pro Pro Arg Val Al<3 Prro Asr, Pro Thr Gly Val Asp Ser A1a
18' 190 195
Met Lys G1u Glu Va: Gln Arg Leu Gl,n Ser Arg Val Asp Leu Leu
<'0(~ 205
210
Glu Glu hys Leu Gln Leu Val Leu Ala Prc: Leu His Ser Leu Ala
2.1 ' 220 225
Ser Gln Ala Leu Glu His Gly Lei: Pro AsF> Pro Gly Ser Leu Leu
23 ) 235 290
Val His Ser Phe Gl:u Gln Leu G1;' Arg Ile Asp Ser Leu Ser Glu
29-~ 250 255
Gln Ile Ser Phe L,e~.a Glu Glu Gltc Leu Gly Ser Cys Ser Cys Lys
267 265 270
Lys Asp Ser
<210. 507
<211? 1700
212> DNA
<213~ Homo sapiens
<400> 507
gccaggcagg tgggcctcag gaggtgcctc caggcggcca gtgggcctga 50
ggccccagca agggctaggg tccatctc.ca gtcccaggac acaacagc:gg 100
ccaccatggc cacgcctggg ctc:ca gce,gc atcagagcag cccca gtggt 150
tggcagcaaa gttcagottg gctgggccvcg ca gtc~agggg cttcgcgcta 200
cgccctgcgg tgtccc~Iagg gctgaggtct cctcatct.tc tccctagcag 250
tggatgagca acccaac;ggg ggcccggc.;ga ggggaactgg c:cccgaggga 300
gaggaacccc aaagccacat ctgtagccvag gatgagcagt gtgaatccag 350
gcagccccca ggaccgggga ggcacagcitg gcccccacca cccggaggag 900
cagctcctgc ccctgt~cgg gggatga::ta attctcctcc gccaggccac 450
ccagaggaga aggcca::ccc gcctggaggc acaggccatg aggggctctc 500
aggaggtgct gctgatgtg g cttc:tggt:,gt tggcagtggg cggcacagag 550
cacgcctacc ggcccggccg tagggtgt:gt gctgtccggg ctcacgggga 600
ccctgtctcc gagtcgttcg tgcagcgtgt gtaccagcco ttcctcacca 650
cctgcgacgg gcaccgggcc tgcagca~~ct accgaaccat ctataggacc 700
gcctaccgcc gcagcc-ctgg gctggcc:~ct gccaggcctc: gctacgcgtg 750
ctgccccggc tggaacagga cc:agcgggct tcctggggcc: tgtggagcag 800
caatatgcca gccgccatgc cggaacggag ggagctgtgt ccagcctggc 850
3 <! 5

CA 02421388 2003-03-25
cgctgccgct gccctgcagg atggcggggt gacacttgcc agtcagatgt 900
ggatgaatgc agtgctacga ggggcggct g tccccagcgc t:gcat.caac:a 950
ccgccggcag ttactggtgc cagtgttggg aggggca<:ag cctgtctgca 1000
gacggtacac t.ctgtgtgcc caagggagc.g c.cc:cccaggg t~ggcccccaa 1050
cccgacagga gtggacac7tg caatgaagga agaagtgcag aggctgcagt 1100
ccagggtgga cctgctggag gagaagctc:c agctggtgct ggccccactg 1150
cacagcctgg cctcgcalgc actggagc<lt gggct~~ccgg accccggcag 1200
cctcctggtg cactccttcc agcagctcgg ccgcatcgac tccctgagcg 1250
agcagatttc cttcctggag gagcagctgg ggtcctgctc ctgcaagaaa 1300
gactcgtgac tgcccagcgc tc<:acgct:~g actgagcccc tcacgccgcc 1350
ctgcagcccc catgcccctg cccaacatgc tgggggtcca gaagccacct 1900
cggggtgact gagcggaagg ccaggcaggg c:cttcctcct cttcctcc:tc 1450
cccttcctcg ggaggctccc cagaccctgg catgggatgg gctgggat_ct 1500
tctctgtgaa tccaccc:ctg gctaccccca ccctggctac cccaacggca 1550
tcccaaggcc aggtggaccc tcagctgagg gaaggtacga gctccctg ct 1600
ggagcctggg acccatUgca caggccaggc agccc:ggagg ctgggtgggg 1650
cctcagtggg ggctgctgcc tga cccc<;ag cacaataaaa atgaaacgtg 1700
<210> 50E~
<~?11> 273
<21.2> PRT
<213> Eiomo Sapiens
<400> 508
Met Arg G.ly Ser Gln Glu Val LF~u Leu Met Trp Leu Leu Val Leu
i 5 J0 75
Ala Val Giy Gly Tnr Glu His ALa Tyr Arg Pro Gly Arg Arg Val
20 25 30
Cys Ala Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val
35 90 95
Gln Arg Val Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg
50 55 60
Ala Cys Ser Thr 7yr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg
65 70 75
Ser Pro Gly Leu 1,1a Pro Ala F,rg Pro F,rg Tyr Ala Cys Cys Pro
80 85 90
Gly Trp Lys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly Ala Ala
95 7.00 105
Iie Cys Gln Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro
IC :.15 120
3 ~~ 6

CA 02421388 2003-03-25
Gly Arg Cys Arg Cy« Pro Aia Gly Trp Arg Gly Asp Thr Cys Gln
12'- 130 135
Ser Asp Val Asp G11:: Cys Ser Ale; Arg Arg Gly Gl.y Cys Pro Gln
19(: 1.4;> 150
Arg Cys Ile Asn Th= F.la G 1y Ser Tyr Trh C:ys Gln C:ys 'rrp Glu
15~, 160 165
Gly His Ser Leu Se_ Ala Asp G1~:; Thr Leu Cys 'Jal Pro Lys Gly
17-~ 175 180
Gly Pro Prc: Arg 'Jai Ala Pro Asn P'ro Thr Gly Val Asp 5er Ala
185 190 195
Met Lys Glu Glu Vai Gln Arg Leu Gln Ser Arg Val Asp Leu Leu
200 205 210
Glu Glu Lys Leu Gln Leu Val Le,~ Ala Pro Leu His Ser Leu Ala
215 220 225
Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro C~ly Ser Leu Leu
230 235 290
Val His Ser Phe Gln Gin lieu Gly Arg Ile Asp Ser Leu Ser Glu
2~!5 250 255
Gln Ile Ser Pi-ie Leu Glu C.;lu Gln Leu Gly Ser Cys Ser Cys Lys
2F.0 265 270
Lys Asp Ser
<210> 509
<211> 1538
<2.12:> DNA
<213> Homo sapiens
<400> 509
cccacgcgtc cgaagctggc cctgcacggc tgcaagqgag gctcctgtgg 50
acaggccagg caggtg:~gcc tcaggagqtg cctccaggcg gccagtgggc 100
ctgaggcccc agcaagggct aaggtccatc tccagtccca ggacacagca 150
gcggccacca tggccacgcc tgggctccag cagcatcagc agcccccagg 200
accggggagg cacaggtggc ccccacc.scc cggaggagca gctcctgccc 250
ctgtccgggg gatgactgat tctcctc~~gc c.aggccaccc: agaggagaag 300
gccaccccgc ctggaggcac aggccatgag gggctctcag gaggtgctgc 350
tgatgtggct tctggtgttg gcagtgggcg gcac:agagca cgcctaccgg 400
cccggccgta gggtgtgtgc tgtccgggct cacggggacc ctgtctccga 450
gtcgttcgtg cagcgtgtgt a~,cagccctt cctc;accacc tgcgacgggc 500
accgggcctg cagcac:ctac cgaaccatct ataggaccgc ctaccgccgc 550
agccctgggc tggccc:ctgc caggcctcgc tacgcgtgct gccccggctg 600
397

CA 02421388 2003-03-25
gaagaggacc agcgggcttc ctggggcctg tggagcagca atatgccaqc 650
cgccatgccg gaacggaggg agctgtgtcc agcctcgccg ctgccgctgc 700
cctgcaggat ggcggggtga cacttgccag tc:agatgtgg atgaatgcag 750
tgctaggagg ggcggcacxtc cccag~~gctg cgtcaacacc gccggcagtt 80G
actggtgcca gtgttgggag ggg:~acagoc tgtctc;caga cggtacactc 850
tgtgtgccca agggaggcrcc ccccagggtg gcccccaacc cgacaggagt 900
ggacagtgca atgaaggaag aagtgcag~_g gctgcagtcc agggtqgacc 950
tgctggagga gaagctg~:ag ctggtgctc;g cccca~~tgca cagcctggcc 1000
tcgcaggcac tggagcatgg gctcccgg<~c cccgg.~agcc tcctggtgca 1050
ctccttccag cagctcggcc gcatcgac'=c cctgagcgag cagatttcct 1100
tcctggagga gcagctgggg tcctcctc~:t gc:aagaaaga ctcgtgactg 1150
cccagcgccc caggctggac tgagcccc~c acgccgccct gcagccccca 1200
tgcccctgcc caacatgctg ggggtccaga ag ccacctcg gggtgactga 1250
gcggaaggcc aggcagggcc ttcctcct~~t tcctcctccc cttcctcggg 1300
aggctcccca gaccctcgca tgggatggg c tgggatcttc tctgtgaatc 1350
cacccctggc tacccccacc ctggctac:cc caacggcatc ccaaggc<;ag 1400
gtgggccctc agctgaggga aggtacgagc: tccct.gctgg agccagggac 1450
ccatggcaca ggccagqcag ccoggagc~ct gggtc~gggcc t.cagtggggg 1500
ctgctgcctg acccccagca caataaaaat gaaacgtg 1538
<210> 510
<~11> 273
<212> PRT
<213> Hcmo sapiens
<400> 510
Met Arg Gly Ser GLn Glu Val Le a Leu Met Trp Leu Leu Val Leu
1 5 :LO 15
Ala Val Gly Gly Tnr Glu His A:.a Tyr Arg Pro Gly Arg Arg Val
?0 25 30
Cys Ala Val Arg Ala His Gly A>p Pro Val Ser Glu Ser Phe Val
35 40 45
Gln Arg Val Tyr Gln Pro Phe h~~u Thr Thr C:ys Asp Gly His Arg
50 55 60
Ala Cys Ser Thr 'Tyr Arg Thr Ile Tyr A.rg Thr Ala Tyr Arg Arg
65 70 75
Ser Pro Gly Leu Ala Pro Ala Arg Pro F,rg Tyr Ala Cys Cys Pro
80 85 90
3 ~18

CA 02421388 2003-03-25
Gly Trp Lys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly F.la Ala
95 100 105
Ile Cys Gln Prc Frc: Cys Arg Asn Gly Gly Ser Cys Val Gln Pro
110 115 120
Gly Arg Cys Arg C.:y~ Pro Ala Gly Trp Arg Gly Asp Thr c'ys Gln
12~. 13G 135
Ser Asp Val Asp Gli.~ Cys Ser A1a Arg Arch Gly Gly Cys Pre Gln
14(~ 14~; 150
Arg Cys Val Asn 'lh:r Ala Gly Ser Tyr Trp Cys (~ln Cys Trp Glu
15~~ 160 165
Gly His Ser Leu Sev Ala Asp G1~, Thr Leu Cys 'Jal fro Lys Gly
17!180
1. 7 0
Gly Pro Pro Arg Va1 Ala Pro Asm Pro Thr Gly Val Asp Ser Ala
180 190 195
Met Lys Glu Glu Va1 Gln Arg Leu Gin Ser Arg Val Asp Leu Leu
200 205 210
Glu G1u Lys Leu Gln Leu Val Leu Al.a Pro Leu His Ser Leu Ala
215 220 225
Ser Gln A1<i Leu Glu His G:ly Leu Prc Asp Pro Gly Ser Leu Leu
230 235 290
Val His Ser Phe Gln Gln L~eu Gl_v Arg Ile Asp Ser Leu Ser Glu
245 250 255
Gln I1e Ser Phe Leu Gl.u (;1u Gln Leu Gly Ser Cys Ser Cys Lys
2(0 2H5 270
Lys Asp Ser
<210:~ 511
<211> 27.
<212> DNA
<213> Artificial
<220>
<221> Artificial Sc-~quence
<222> 1-21
<2'23> Artificial Sequence
<900> 51?
tggagcagca atatgc;~agc c 21
<210> 512
<211> 22
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence=
<222> 1-22
<223> Artificial Sequence
<900> 512
349

CA 02421388 2003-03-25
ttttccacr_c ctgtcgggt.t gg <'2
~:210> 513
<211> 46
<2 12> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> l.-96
<223> Artificial Sequence
<900> 513
ggtgacactt gccagtcaga tgtggatgaa tgcagtgcta ggaggg 96
<210> 519
<211> 2690
<212> DNA
<213> Homo Sapiens
<220>
<221> unsure
<222> 2039-2065
<223> unknown base
<40C> 514
ggttgccaca gctggtttag ggccccgacc actggggccc cttgtcagga 50
ggagacagcc tcc:cggcccg gggaggacaa gtcgctgcca cctttggctg 100
ccgacgtgat tccctgc;gac ggtc~~gtttc ctgccgtcag ctgccggccg 150
agttgggtct ccgtgt~,.tca ggccggctcc cccti:cctgg tctcccttct 200
cccgctgggc cggttta~tcg ggaggagatt gtctt ccagg gctagcaati_ 250
ggacttttga tgatgtttga cccagcggca ggaavagcag gcaacgtgat 30C
ttcaaagctg ggctcagcct ct-gtttcttc tctcgtgtaa tcgcaaaacc 350
cattttggag caggaatt<:c aatcatgtct gtgatggt.gg tgagaaagaa 400
ggtgacacgg aaatgggaga aactccc,~gg caggaacacc ttttgctgtg 450
atggccgcgt catgat:ggcc cggcaaaagg gcattttcta cctgaccctt 500
ttcctcatcc tggggacatg tacactc=tc ttcgcctt:tg agtgccgcta 550
cctgqctgtt cagctatctc ctgccatccc tgtatttgct gccatgctct 600
tccttttctc catggctaca ct gt:tgagga ccagcttcag tgaccct:gga 650
gtgattcctc gggcg<:tacc ac~atgaagca gctttcatag aaatggagat 700
agaagctacc aatggtgcgg tgccccaggg ccaqcgacca ccgc~~tcgta 750
tcaagaattt ccagataaac aaccagattg tga~cac:tgaa atactgttac 800
acatgcaaga tcttcc:ggcc tcc~ccg<~gcc tcc<:attgca gcatctgtga 850
caactgtgtg gagcgcvtt.cg accatcactg cccctgggtg gggaattgtg 900
ttggaaagag gaactaccgc tacttci_acc tctt:catcct ttctctctcc 950
350

CA 02421388 2003-03-25
ctcctcacaa tctatgtc:tt cgccttcaac atcgtcaatg tggccctcaa 7.000
atctttgaaa at:tggctt ct tggagacatt gaaagaaact c:ctggaact.g 1050
ttctagaagt cctcatt'gc ttctttacac tctggtccgt c:gtgggactg 1100
actggatttc atactttc:ct cgtggctcic aaccagacaa coaatgaaga 1150
catcaaagga tcatgga:ag ggaagaatc:g cgtccagaat ccctacagcc 1200
atggcaatat tgtgaagaac tgctgtga:ug i_gctgt:.gtgg ccccttgccc 1250
cccagtgtgc tggatcgaag gggtattt",=g cc:actggagg aaagtggaag 1300
tcgacctccc agtactcaag agaccagt<~g cagcctcttg ccacagagcc 1350
cagcccccac agaacacctg aac:tc:aaa~:g agatgccgga ggacagcagc 1900
actcccgaag agatgccacc tccagagc~:;c ccagagccac cacaggaggc 1450
agctgaagct gagaagtagc ctatcaat~~g aagagacttt tgtttgtgtt 1500
taattagggc tatgagagat ttc:ag gtgag aagttaaac:c tgagacagag 2550
agcaagtaag ctgtc:ccttt t::a<ictgtttt tctttggtct ttagtcaccc 1600
agttgcacac tggcattttc ttg ctgcaag cttttttaaa tttctgaa ct 1650
caaggcagtg gcagaacaatg tcagtcac~ct: ctgataactg gaaaaatggg 1700
tctcttgggc c.ctggc<.:ctg gttctccatg gcctcagcca cagggtcccc 1750
ttggaccccc tctcttc:cct ccagatcc::c:a gccctcctgc ttggggtcac 1800
tggtctcatt ctggggcaaa aagttttt.ga gactc~gctca aatcctccca 1850
agctgctgca cgtgctgagt ccagaggc:ag tcac,~gagac ctctggccag 1900
gggatcctaa ctgggt~ctt ggggtctt:ca ggactgaaga ggagggagag 1950
tggggtcaga agattctcct ggccacc<~ag tgccagcatt gcccacaaat 2000
ccttttagga at.gggacagg taccttc~:~ac ttgttgtann nnnnnnnnnn 2050
nnnnnnr.nnn nr:nnnttgtt. tttccttttg actcctgctc ccattaggag 2100
caggaatggc agtaataaaa gtctgcactt tggtcatttc ttttcctcag 2150
aggaagcccg agtgctcact taaacactat cccctcagac tccctgtgtg 2200
aggc:ctgcag aggccctgaa tgcacaaatg ggaaaccaag gcacagagag 2250
gct.ctcctct cctctcctct cccc:cgatgt accca caaaa aaaaaaaaat 2300
gctaaccagt tctt.ccatta agcctcggct gagt:gaggga aagcccagca 2350
ctgctgccct ctcgggtaac tcawcctaag gcct:cggccc acctctggct 2400
atggtaacca cactgggggc ttcctcc:aag ccccgctctt ccagcacttc 2450
caccggcaga gtccc<igagc cacttcaccc tgggggtggg ctgtggcccc 2500
351

CA 02421388 2003-03-25
cagtcagctc tgctcaggac ctgctctatt tcagggaaga agatttatgt. 2550
attatatgtg gctatatttc ct.aqagcacc tgt.gttttcc tctttctaag 2600
ccagggtcct gtctggatga cttatgcggt gggggagtgt aaaccggaac 2650
ttttcatcta tttgaagc;cg attaaactc;t gtctaatgca 2690
<210> 515
<2'11> 369
<2>1i_'> PRT
<213:> Homo sapiens
<400> 515
Met Ser Val Met Val Val P.rg Ly:, Lys Val Thr Arg Lys Trp Gl.u
Lys Leu Pro Gl.y Ar:l Asn Thr Phe- Cys Cys Asp Gly Arg Val Met
2.'> 3G
Met Ala Arg Gln Lys Gly Ile Phi: Tyr Leu Thr Leu Phe Leu Ile
35 90 45
Leu Gly Thr Cys Thr Leu F'hE: Phe Al.a Phe Glu Cys Arg Tyr Leu
50 55 60
Ala Val Gln Leu Ser Pr.e Ala Ile Pro Val Phe Ala Ala Met Leu
E-5 70 75
Phe Leu Phe Ser Met Ala _'hr Leu Leu Arg Thr Ser Phe Ser Asp
E'; 0 ~ 5 9 0
Pro Gly Vai Ile Pro Arg Ala Le~u Pro Asp Glu Ala Ala Phe Ile
fa5 100 105
Glu Met Glu Ile G~.u Ala Thr Asn Gly Ala Val Pro Gln Gly Gln
1 i 0 1. 5 120
Arg Pro Pro Pro Arg Ile Lys Ann Phe G.ln Ile Asn Asn Gln Ile
1:'S 130 135
Val Lys Leu Lys Tyr Cys 'I'yr Thr C:ys Lys Ile Phe Arg Pro Pro
1~0 145 150
Arg Ala Ser His Cys Ser Ile Cys Asp Asn Cys 'Jal Glu Arg Phe
155 160 165
Asp His His Cys Fro Trp Val Gly Asn Cys Val Gly Lys Arg Asn
170 175 180
Tyr Arg Tyr Phe Tyr Leu Phe I.Le Leu Ser Leu Ser Leu Leu Thr
785 190 195
Ile Tyr Val Phe F.la Phe Asn Ile Val Tyr Val Ala Leu Lys Ser
200 205 210
Leu Lys I.le Gly Phe Leu Glu Thr Leu hys Glu Thr Pro Gly Thr
a15 220 225
Val Leu Glu Val I,eu Ile Cys Phe Phe Thr Leu Trp Ser Val Val
a 30 a:35 240
Gl.y Leu Thr Gly Phe His T:nr Phe Leu Val Ala Leu Asn Gln Thr
3 -'':~ 2

CA 02421388 2003-03-25
245 250 255
Tl:r Asn G.lu Asp Ile Lys Gly Ser Trp Thr Gly Lys Asn Arg Val
26C: 265 270
Gln Asn Fro Tyr Ser His Gly Asn Ile Val Lys Asn Cys C'ys Glu
27': 280 285
Val Leu Cys Gly Fr< Leu Pro Pro Ser VaI Leu Asp Arg Arg Gly
i:9C: 295 300
Tle Leu Pro Leu C;lt. Glu S<~r Gly Ser Arq Pro Pro Ser ':'hr Gln
30'. 310 315
Glu Thr Ser Ser Ser Leu Leu Prc. GIn Ser Pro AIa Pro Thr G1u
32t,) 32_'330
His Leu Asn Ser Asr: Glu Met Prc~ Gl.u Asp Ser :3er Thr Pro Glu
33'~ 390 345
Glu Met Pro Pro Pr:> Glu Pro Prco Glu Pro Pro Gln Glu Ala Ala
350 35~ 360
Glu Ala Glu Lys
<210> 516
<211> 255
<212> DNA
<213> Homo sapiens
<220~
<221> unsure
<222> 36, 38, 88, 718, 13'., 19 ~, 213, 222
<'223> unknown base
<400> 51b
aaaaccctgt attttttaca atgcaaatag acaatnancc tggaggtcat 50
tgaattaggt attatac;(gga tggtggggtt gatttatntt cctggaggct 100
tttggctttg gactctcwct ttctccc~aca gagcncttcg accatcac.tg 150
cccctgggtg gggaattgtg ttggaaa<aag gaact:accgc tanttctacc 200
tcttcatcct ttntct~.acc cncctca~:aa tctatgtctt cgccttcaac 250
atcgt 255
<210> 517
<211> 24
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 517
caacgtgatt tcaaagctgg gctc 24
<210> 518
353

CA 02421388 2003-03-25
<211> 20
x212%~ DNA
<213> Artificial
'~2GO%~
<2~1> Artificial Se<luence
<222> 1-20
<223> Artifi.ci.al Sequence
<400> 518
gcctcgtatc aagaatt'cc 20
<210> 5i9
<211> 18
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-78
<223> Art:ifici.al Sequence
<400> 519
agtggaagtc gacctccc 18
<210> 520
<:211> 24
<:212> DNA
<:213=> Artificial
<220>
<::221> Artificial Sequence
<222:> 1-29
<223> Artificial Sequence
<400> 520
ctcacctgaa atctctc:ata gccc 29
'2i0> 521
<'211> 50
<212> DNA
<213> Artificial
<220>
<227> Artificial Sequence
<222> 1-50
<223> Artificial SequencF
<400> 521
cgcaaaaccc attttgggag coggaat:cc aatcatgt:ct gtgatggtgg 50
<210> 522
<211> 1679
<212> DNA
<213> Homo Sapiens
<900> 522
gttgtgtcct tcagcaaaac aqtggattta aatcaccttg cacaagcttg 50
agagcaacac aatct~:tcag gaaaga<~aga aag~iaaaaaa ccgaac~~tga 100
caaaaaagaa gaaaaagaag aaga aaaaaa atcatgaaaa ccatccagcc 150
354

CA 02421388 2003-03-25
aaaaatgcac aatt:ctatct cttgggcaat cttcacgggg caggctgcr_c 200
tgtgtctctt ccaaggaatg cccgtgcgca gcggagatgc caccttccc;c 250
aaagctatgg acaacgtc;ac ggtccggc~;g ggggacaagcg ccaccctcag 300
gtgcactatt gacaacccagg tca;;ccggct ggcctggcta aaccgcag;:a 350
ccatcctcta tgctgggaat gacaagtg<at gcctggatcc tcgcgtggtc 400
cttctgagca acacccaaac- gcagtacayc atcgagatcc agaacgtgga 450
tgtgtatgac gagggcc.-tt acacctgctc ggtgcagaca gacaaccacc 500
caaagacctc tagggtc:~ac ctcattgtc:3c aagtatctcc caaaattgta 550
gagatttctt cagatat..tc cattaatgaa gggaacaata ttagcctcac 600
ctgcatagca actggtagac cagagcct,3c ggttacttgg agacacatct 650
ctcccaaagc ggttggcttt gtc~agtga,sg acgaatactt ggaaattcag 700
ggcatcaccc gggagcagtc aggggactac gagtgcagtg cctccaatga 750
cgtggccgcg cccgtggtac ggagagtaaa ggtcaccgtg aactatc<:ac 800
catacatttc agaagcraag ggtacagqtg tcccc:gtggg acaaaagggg 850
acactgcagt gtgaagc:ctc: agcagtcccc tcagc:agaat tccagtggta 900
caaggatgac aaaagactga tt,:3aaggaaa gaaaggggtg aaagtggaaa 950
acagaccttt cctctca-~aaa ctcatcttct tcaatgtctc t.gaacatgac 1000
tatgggaact acacttqcgt ggcctcc~;ac aagci_gggcc acaccaatgc 1050
cagcatcatg ctattt~~gtc caggcgcc:gt cagcgaggtg agcaacggca 1100
cgtcgaggag ggcaggc~tgc gtctggctgc tgcctcttct ggtcttgcac 1150
ctgcttctca aatttt:~atg tgagtgc::ac: ttccccaccc gggaaaggct 1200
gccgccacca ccaccaccaa cacaacagca atggcaacac cgacagcaac 1250
caatcagata tatacaaatg aaattag,aag aaacacapcc tcatgggaca 1360
gaaatttgag ggaggggaac aaagaat:~ct ttggggggaa aagagtttta 1350
aaaaagaaat tgaaaattgc: cttgcagata tttaggtaca atggagtttt 1400
cttttcccaa acgggoagaa cacagca~ae ccggct:tgga cccactgcaa 1450
gctgcatcgt gcaacctctt tg gtgcc:agt gtgqgcaagg gctcagc:ctc 1500
tctgcccaca gagtgc:cccc ac,gtggaaca ttct.ggagct ggccate:cca 1550
aattcaatca gtccaLagag ac:gaacagaa tgac~accttc cggcccaagc 1606
gtggcgctgc gggcar:tttg gtag actgtg cca<:cacggc gt.gtgttgtg 1650
aaacgtgaaa taaaaagagc aaaaaauaa 1679
<210> 523
355

CA 02421388 2003-03-25
<211> 349
<21.2> PRT
<21.3> Homo Sapiens
<4C0> 523
Met Lys Thr Ile C~lr~ Pro I,ys Met His Asn Ser Il.e Ser 'I'rp Ala
i ' 10 15
Ile Phe Thr Gly Leu Ala Ala Lea Cys Leu Phe Gln Gly 'Jal Prc
2ty 2'~ 30
Val Arg Ser Gly Asp Ala Thr Phe Fro Lys Ala Met Asp Asn Val
3 i 90 95
Thr Val Arg Gln Gly Glu Ser Al,3 Thr Leu Arg ~.ys 'I'hr Iie Asp
50 5'. 60
Asn Arg Val Thr Arg Val Ala Trt~ Leu Asn Arg Ser Thr Ile Leu
65 70 75
Tyr Ala Gly Asn Asp Lys Trp Cy:~ Leu Asp Pro Arg Val Val Leu
80 85 90
Leu Ser Asn Thr Gln Thr Gln Tyr Ser Ile Glu Iie Gln Asn Val
~5 100 105
Asp Val Tyr Asp Glu Gly Fero Tyr Thr Cys Ser Val Gln Thr Asp
110 115 120
Asn His Pro Lys TYr Ser Arg Val His Leu Ile Val Gln Val Ser
125 1'0 135
Fro Lys Ile Val G-a Ile ;e:r Se:r Asp Il.e Ser Ile Asn Gl.u Gly
1~i0 145 150
Asn Asn Ile Ser LE'u Thr Cys I2.e Al.a Thr Gly Arg Fro Glu Pro
1p5 1E;0 165
Thr Val Thr Trp A.rg His I:le S<~r Pro Lys Ala Val Gly Phe Val
1 %0 1'75 180
Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr Arg Giu Gln
185 190 195
Ser Gly Asp Tyr Glu Cys Ser A_a Ser Asn Asp Vai Ala Ala Fro
200 205 210
Val Val Arg Arg Val Lys Val Thr val Asn 'I'yr Pro Prc, Tyr Ile
215 220 225
Ser Glu Ala Lys Gly Thr Gly Val. Pro Val Gly Gln Lys Gly Thr
230 235 290
Leu Gln Cys Glu Ala Ser Aia Val t?ro Ser Ala Glu Fhe Gln Trp
a45 250 255
Tyr Lys Asp Asp lays Arg Leu Lle Glu C~ly Lys Lys Gly Val Lys
a'60 a:6'_i 270
Val Glu Asn Arg Hrc Phe Leu :ver Lys Leu Il<_> Phe Phe Asn Val
275 280 285
Ser Glu His Asp ":'yr Gly Asn 'Cyr Thr (:ys Val Ala Ser Asn Lys
356

CA 02421388 2003-03-25
29C 295 300
I~eu Gly His Thr Asr~ Ala Ser Ile Met Leu Phe Gly Fro Gly Ala
30' 31C 315
Val Ser Glu Val :~ex Asn Gl.y Thl Ser Arq Arg Ala Gly Cys Val
32( 325 330
Trp Leu Leu Pro Leu Leu Val Lei: His Leu Leu Leu hys Phe
33'; 390
<210> 529
<211> 503
<212> DNA
<213> Homo Sapiens
<400> 524
gaaaaaaaat catgaaaacc atccagccaa aaatgcacaa ttctatctct 50
tgggcaatct tcacggg:4ct ggctgctc~:g tgtctcttcc aaggagtgcc 100
cgtgcgcagc ggagatg:oca ccttcccc~ja agctatggac aacgtgac:gg 150
tccggcaggg ggagagcgcc accctcaggt gcactattga caaccgggtc 200
acccgggtgg cctggctaaa ccgcagcacc atcctctatg ctgggaatga 250
caagtggtgc ctggatc:ctc gcatggtcct tctgagcaac acccaaacgc 300
agtacagcat cgagatccag aacgtggatg tgtatgacga gggcccttac 350
acctgctcgg tgcagacaga caaccaccoa aagacctcta gggtccac:ct 400
cattgtgcaa gtatctccca aaattgtaga gattt.cttca gatatctc~ca 950
ttaatgaagg gaacaa? att age:ctcacct gcatagcaac tggtagac~ca 500
gag 503
<210> 525
<211> 2602
<21Z> DNA
<213> Homo Sapiens
<400> 525
atggctggtg acggcggggc cgggcagggg accggggccg cggcccggga 50
gcgggccagc tgccgggagc cctgaatcac cgcctggccc gactccacca 100
tgaacgtcgc gctgcaggag ctgggagutg gcagcaac:gt gggattccag 150
aaggggacaa gacagctgtt. aggca cac:gc acgcagct.gg agctggtctt 200
agcaggtgcc tctctactgc tggctgcact gcttct.gggc: tgccttgtgg 250
ccctaggggt ccagtoccac agagacccat cccacagc:ac ctgccttaca 300
gaggcctgca ttcgactggc tqgaaaaatc ctggagtccc: tggaccgagg 350
ggtgagcccc tgtgaggact tttaccagtt ctcc:tgtggg ggctggattc 400
ggaggaaccc cctgcc:cga t gggcgtt ctc gctggaaca<: ctt:caacagc 450
357

CA 02421388 2003-03-25
ctctgggacc aaaaccaggc catactgaag cacctgcttg aaaacaccac 500
cttcaactcc agcagtgaag ctgagcagaa gacacagcgc ttctacctat 550
cttgcctaca ggtggagogc attgaggagc tgggaaccca ctCCactgac:~a 600
gacctcattg agaagatt gg tggt:tggaac attacc~gggc c:ctgggacca 650
ggacaacttt atggaggtgt tgaagg cac;t agcagc~gacc t~acagggcca 700
c~cacattctt caccgtc~:aa atcagtgcrg actct<3agag r_tccaacagc 750
aatgttatcc aggtgga~:ca gtctgggctc tttctgccct ctcgggatta 800
ctacttaaac agaactg;:ca atgagaaacTt gctcactgcc tatctggatt 850
acatggagga actgggg;~tg ctgctggg'=g ggcgg~~ccac ctccacgagg 900
gagcagatgc agcaggty ct= ggagttgga g at.acagctgg ccaacatcac 950
agtgccccag gaccagcggc gcgacgagga gaagatctac cacaagatga 1000
gcatttcgga gctgcaggct ctggcgccct ::catggactg gcttgagttc 1050
ctgtctttct tgctgtc:acc attggagttg agtgactctg agcctgtggt 1100
ggtgtatggg atggattatt t.gc:agcaggt gtcagagctc atcaaccgca 1150
cggaaccaag catcctaaac aattacctga tctggaacct ggtgcaaaag 1200
acaacctcaa gcctggaccg acgcl~ttgag tctgc:acaag agaagc:tgct 1250
ggagaccctc tatggc<cta agaagtcc;tg t.gtgc:cgagg tggc:agacct 1300
acatctccaa cacggatgac: gcccttggct ttgct:ttggg gtcactc~t.c 1350
gtgaaggcca cgtttga-lccg gcr~aagca~aa gaaat tgcag aggggatgat 1400
cagcgaaatc cggaccrtcat ttgaggac:,gc:. c:ctgc3gacag ctggtttgga 1450
tggatgagaa gacccg<;cag gcagccaa gg agaaagcaga tgccatctat 1500
gatatgattg gtttcc:.aga ctttatc::ag gagcccaaag agctggatga 1550
tgtttatgac gggtac3aaa tttctgaaga ttctttcttc caaaacatgt 1600
tgaatttgta caactt~~tct gccaaggt.ta t_ggctgacca gctccgcaag 1650
cctcccagcc gagacc.agtg gagcatga cc ccccagacag tgaatgccta 1700
ctaccttcca actaagaatg agatcgt:at ccccgctggc atcctgcagg 17'>0
cccccttcta tgcccgcaac cacc:ccaa~gg ccctgaactt cggtggr:atc 1800
ggtgtggtca tgggccatga gttgacgcat gcctttgatg accaagggcg 1850
cgagtatgac aaagaaggga ac:ct:gcggcc ca ggtggcaq aatgagtccc 1900
tggcagcctt ccggaa~ccac ac:ggcctgca tggaggaaca gtacaatcaa 1950
taccaggtca atggggagag gcac~aacggc cgcc:agacgc tgggggagaa 2000
cattactgac aacggc~gggv tga,sggctgc ctacaatgct tacaaagcat 2050
358

CA 02421388 2003-03-25
ggctgagaaa gcatggggag gagceagcaac tgccagccgt ggggctcacc 2100
aaccaccagc tcttct.tc:gt gggatttgcc caggtcrtggt gctcggtccg 2150
cacaccagag agctctcacg aggggctggt gaccgacccc <:acagccctg 2200
cccgcttccg cgtgctgqgc actct~Ltc<~a actcccgtga cttcctgcgg 2250
cacttcggct gccctgtogg ctcccccat.g aacccagggc agctgtgtga 2300
ggtgtggtag acctggatca ggggagaaat ggccagctgt caccagacct 2350
ggggcagct:c tcctgac<3aa gctgtttgia catgggttgg gaggaagcaa 2900
atgcaagctg ggctgggtct agtccct.c~:c cccca~~aggt gacatgagta 2450
cagaccctcc tcaatcacca cattgtgc;:~t ctgctttggg ggtgcccctg 2506
cctccagcag agccccc,~cc att:cactg~::g acatctttcc gtgtcaccct 2550
gcctggaaga ggtctgggtg gggaggcc,:~g ttcccatagg aaggagtctg 2600
cc 2602
<210> 526
<211> 736
<212> PRT
<213> Homo Sapiens
<900> 525
Met Asn Val Ala LE~u GIn alu Leu Gl.y A7.a Gl.y Ser Asn Val Gly
1 5 7 0 1. 5
Phe GI,n Lys Gly Thr Arg ~:~ln Leu heu G_y Ser Arg Thr Gln Leu
:'0 a?5 30
Glu Leu Val Leu Ala Gly Ala Scv,r Lea Le a heu Ala Ala Leu Leu
i5 ~10 95
Leu Gly Cys Leu Val Ala L~eu Gy 'Jal Gln Tyr tlis Arg Asp Pro
30 15 60
Ser His Ser Thr Cys Leu Thr Giu Ala Cys Lle Arg Val Ala Gly
65 70 75
Lys Ile Leu Glu Ser Leu Asp Arg Gly Val Ser Pro Cys Glu Asp
90 85 90
Phe Tyr Gln Phe Ser Cys Gly Gly 'I'rp Ile Arg Arg Asn Pro Leu
95 100 105
Pro Asp Gly Arg Ser Arg 'rrp Asn Th r Fhe Asn Ser Leu Trp Asp
110 115 120
Gln Asn Gln Ala Ile Leu L_vs His Leu heu Glu Asn Thr Thr Phe
125 130 135
Asn Ser Ser Ser <;1u Ala Glu Cln Lys Thr Gln Arg Phe Tyr Leu
~9G 145 150
Ser Cys Leu Gln Val Glu Arg ~le Glu Glu Leu Gly Ala Gln Pro
55 ., 60 165
3 !~ 9

CA 02421388 2003-03-25
Leu Arg Asp Leu 11E Glu Lys Ile Gly Gly Trp Asn Ile 'I'hr Gly
17C 175 180
Pro Trp Asp Gln AsI- Asn Fhe Met Glu Val Leu Lys Ala Val Ala
18' 190 195
Gly Thr Tyr P.rg Alra Thr Pro Phe Phe Thr Val Tyr I:le Ser Ala
20(' 205 210
Asp Ser Lys Ser Ser Asn Ser Asn Val Ile Gln 'Jal Asp Gln Ser
21', 220 225
Giy Leu Phe Leu Pr~~ Ser Arg Asx> Tyr Ty.r Leu Asn Arg Thr Al.a
23:) 23'~ 240
Asn Glu Lys Val Leu Thr Ala Tyr L,eu Asp Tyr Met Glu Glu Leu
245 250 255
Gly Met Leu Leu Gly Gly Ara_ Pre Thr Ser Thr Arg Glu Gln Met
260 265 27C
Gln Gln Val Leu Glu Leu C~lu Ile G.l_n Leu Ala Asn Ile Thr Val
275 280 285
Pro Gln Asp Gln Arg Arg Asp Glw Glu Lys Ile Tyr Hl.s Lys Met
2G0 295 300
Ser Ile Ser Glu Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu
3f~5 310 315
Glu Phe Leu Ser PY:e Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser
3r'0 325 330
Glu Pro Val Val Val Tyr Gly Met Asp Tyr Leu Gln Gln Val Ser
3a5 340 345
Glu Leu Ile Asn Arg Thr ~=lu P:o Ser I:Le Leu Asn Asn Tyr Leu
350 355 350
Ile Trp Asn Leu Val Gln Lys TPnr Thr Ser Ser Leu Asp Arg Arg
3~5 3'70 375
Phe Glu Ser Ala Gln Glu Lys Leu L,eu Glu Thr Leu Tyr Gly Thr
380 385 390
Lys Lys Ser C.'ys Val Pro Arg Trp G In Thr Cys Ile Sex Asn Thr
395 400 405
Asp Asp Ala Leu GIy Phe Ala Leu Gly Ser Leu Phe Val Lys Ala
910 415 420
Thr Phe Asp Arg C--In Ser Lys Glu Tle Ala Gla Gly Met. Ile Ser
925 930 435
Glu Ile Arg Thr F;la Phe G:Lu C;lu Ala heu Gly Gln Leu Val Trp
490 945 450
Met Asp Glu Lys Thr Arg Gln Ala Ala hys Glu Lys Ala Asp Ala
955 460 465
Ile Tyr Asp Met ;:1e Gly P:~e I-'ro Asp I?he Ile Leu Gla Pro Lys
470 <175 480
360

CA 02421388 2003-03-25
Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser
48~- 99C 495
Phe Fhe Gln Asn Met Leu Asn Let: Tyr Asn Phe Ser Ala L~ys Val
50C 50't 510
Met Ala Asp C-In Lei; Arg Lys Pr;Pro Ser Arg Asp Gln 'I'rp Ser
51-'520 525
Met Thr Pro Gln Th; Val Asn Al~a Tyr Tyr heu Pro Thr i.,ys Asn
53~~ 535 540
Glu Ile Val Phe Pr~:~ Ala Gl.y I1:' Leu Glo Ala Pro Phe Tyr Ala
54=> 55~~ 555
Arg Asn His Pro Lys Ala Leu P.su Phe Gly Gly Ile Gly Val Val
SEA 565 570
Met Gly His G1_u Leu Thr His Al,~ Phe Asp Asp Gln Gly Arg Glu
575 580 585
Tyr Asp Lys Glu Gly Asn I,eu Arg Pre Trp Trp Gln Asn Glu Ser
590 595 600
Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met Glu Giu Gln Tyr
6G5 610 615
Asn Gln Tyr Gln V~~1 Asn C,lv Glu Arg Leu Asn Gly Arg Gln Thr
6a0 ~ 625 630
Leu Gly Glu Asn Ile Thr Asp Asn Gly Gly Leu Lys Ala Ala Tyr
6: 5 640 645
Asn Ala Tyr Lys A~a Trp Leu Arg Lys His Gly Gl.u Glu Gln Gln
6'>0 655 660
Leu Pro Ala Val G.~y Leu 'Chr Ann His Gln Leu Phe Phe Val Gly
6~;5 b'70 675
Phe Ala Gln Val Tip Cys Ser V~~1 Arg Thr Pro Glu Ser Ser His
630 6~=>5 690
Glu Gly Leu Val T:~r Asp Pro His Ser Pro Ala Arg Phe Arg Val
695 700 705
Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly
710 715 720
Cys Pro Val Gly Ser Pro Met A:~n Pro Gly Gln Leu Cys Glu Val.
725 730 735
Trp
<210> 527
<211> 4308
<212> DNA
<213> Homo sapien:;
<220>
<221> unsure
<222> 1978, 3978, 4057-9058, 4070
3iil

CA 02421388 2003-03-25
~223> unknown base
<400> 527
gcccggccct ccgccctc:cg cactcccgr~ tccctccctc c:gcccgctcc 50
cgcgccctcc tccctccctc ctccccagct gtcccgttcg <:gtcatgccg 100
agcctcccgg ccccgcccrgc cccgc~gctg ctcctc:gggc tgctgctgct 150
cggctcccgg ccggcccgcg gcgc:cggcc:c agagcccccc gtgctgccca 200
tccgttctga gaaggagc:cg ctgcccgttc ggggagcggc aggtaggtgg 250
gcgcccgggg gaggcgcyagg cggggagtcg ggctcg gggc gagtcagcgc 300
cagcccggag ggggcgc;:agg gcgcaggtclg ctcggcgcgg cgggcggccc 350
ggagggtggg cgggggc,~ga agggcgcggt gcctgggacc cgggacccgc 400
gggcagcccc cggggcggca cacggcgccla gctgggcagc ggcctccagc 950
caagcccgtc cccgcaggct gcaccttcc~g cgggaaggtc tatgccttgg 500
acgagacgtg gcacccggac ct.aggggac~c cattcggggt gatgcgctgc 550
gtgctgtgcg cctgcgaggc gccagtggggt caccgtacca ggggccctgg 600
cagggtcagc tgcaagaaca tcaaaccaga gtgcccaacc ccggcctgtg 650
ggcagccgcg ccagctaccg ggac<ict~ct, g<.:cagacctg cccccaggac 700
ttcgtggcgc tgctgac:agg gcc:gaggt cg caggcggtgg cacgagc<;cg 750
agtctcgctg ctgcgcicta gcca ccgctt ct:.ctatctcc tacaggcggc 800
tggaccgccc taccagciatc cgc;ttctcag actcc:aatgg cagtgtcct.g 850
tttgagcacc ctgcage ccc cacccaac:aat. ggcctggtct gtggggtgtg 900
gcgggcagtg cctcgg~:tgt ctctgcgact. ccttagggca gaacagctgc 950
atgtggcact tgtgac:~ctc actcacc~at caggggaggt ca gggggcct 1000
ctcatccggc accggg:_cct gtccccaqag acctt.cagtg ccatcctgac 1050
tctagaaggc ccccac~agc agggcgt<~gg gggcatcacc ctgctcactc 1100
tcagtgacac agaggactcc ttgcattt:tt tgctgctctt ccgaggcctt 1150
gcaggactaa cccaggttcc cttcagg,~tc cagattctac accaggggca 1200
gctactgcga gaacttcagg ccaatgtctc agcccaggaa ccaggctttg 1250
ctgaggtgct gcccaacctg acagtccagg agatggactg gctggtgctg 1300
ggggagctgc agatggccct ggagtgg:3ca ggcaggccag ggctgcgcat 1350
cagtggacac attgctgcca ggaagagctg cgac:gtcctg caaagtgtcc 1900
tttgtggggc taatgccctg at:cccaatcc aaac:gggtgc tgccggctca 1450
gccagcctca ctctgr-tagg aaa~ggc-ncc ctgatcctcc aggtgcaott 1500
3p2

CA 02421388 2003-03-25
ggt.agggaca accagtgGgg tggtggccat gacactggaa accaagcctc 1550
agcggaggga tcagcccacct gtcc~tgtgoc acatggctgg c:ctatcctcc 1600
c:ctgccccca ggccgtgcagt atctgccct.g ggctggggtg cccgaggggc 1650
tcatatgctg ctgcaga<-;tg agctcttcc:t. gaacgi.gqgc <3ccaaggact 1700
tcccagacgg agagcttcgg gggcaacgtg gctgccctgc c ctactgtgg 1750
ggcatagcgc ccgccctgcc cgtgcccct:a gcaggagccc tggtgctacc 1800
ccctgtgaag agccaagcag cagggcac:;3c ctggctttcc ttggat.accc 1850
actgtcacct gcactatgaa gtgctgctcxg cctgggcttgg tggctcagaa 1900
caaggcactg tcactgcc ca cctc cttg;xg cctcctggaa cgccagggcc 1950
tcggcggctg ctgaagggat tctat.ggctc agaggcccag ggtgtggtga 2000
aggacctgga gccggaactg ctgcggcacc tggcaaaagg catggcttcc 2050
ctgatgatca ccaccaaggt ag<:cc:cag.ag gcxgagctccg agggcagcct 2100
ctcctcccag gtgcacatag ccaa<:caatg tgaggttggc ggactgcgcc 2150
tggaggcg gc cggggcrgag ggggtgccagg cgctqggggc tccggat<--~ca 2200
gcctct.gctg cgccgcctgt ggtgcctcagt. ctccc:ggccc tagcgcccgc 2250
caaacctggt ggtc<acaggc gg<:cccgaga c:ccc<iac:aca tgcttcttcg 2300
aggggcagca gcgcccc;cac ggggctcg ct. gggcg cccaa ctacgacccg 2350
ctctgctcac tctgca<:ct.g ccagaga~,ga acggtgatct gtgacccggt 2900
ggtgtgccca ccgccc:~gct gc_ccacar:cc ggtgcaggct cccgaccagt 2450
gctgccctgt t;tgccctggc tgctatt~:t=g atggtgaccg gagctggcgg 2500
gcagcgggta cgcggt.~gca ccccgttc:~tg cccccctttg g cttaattaa 2550
gtgtgctgtc tacacctgca aacaggg:~gg cactggagag gtgcactgtg 2600
agaaggtgca gtgtccccgg ctggcct::xtg cccagcctgt gcgtgtc.aac 2650
cccaccgact gctgcaaaca gtgtcca:~gt: gaggcccacc cccagctggg 2700
ggaccccatg caggctgatg ggccccgggg ctgccgtttt gctgggcagt 2750
ggttcccaga gagtcagagc tggcacccct c:agtgccccc: gtttggagag 2800
atgagctgta tcacctgcag atgtggggta agtggggagc agaggct:tgt 2850
gtgaggtggg tactgggagc ctggtctgga gtagggagac: cttcccaggg 2900
aggtccctga agaag<agaa ggt~~actgtg tccc:agtgcc tctgggggac 2950
actcagtgtc tgctct.gtct tgt.accaggc aggggtgcct cactgtgagc 3000
gggatgactg ttcacrgcca c:tgtcctgtg gctcggggaa ggagagtcga 3050
tgctgttccc gctgcacggc ccaccgcrcgg cgt<3agtgag ggagtccagg 3100
363

CA 02421388 2003-03-25
gtcagcagct gtgagtggag ggctcacctg cctgtgggac tcctgat.cag 3150
ggaagggagc actr_actgtg tgcaggaaca gtgcagcctg cctcacaagt 3200
gccattccaa tccaccctca cagcaacctg gtggaa.ttgt: tatttatgac 3250
cttttcttta caaatgacaat ttct=gaagct cagagaaatt aagcaacgag 3300
atgaaggtca cccagctcrtg tgcactgacc tgttt<igaaa atactggcct 3350
ttctgggacc aaggcaggga tgctttgccc tgccctctat gcctctctgt 3400
gcctctccac tccctcta cc ctcctcca<,c- attccctccc ttctgtctcc 3950
agcagcccca gagaccagaa ctgatcca<~a gctggagaaa gaagccgaag 3500
gctcttaggg agcagccaga gggccaagt:g accaagagga tggggcct.ga 3550
gctggggaag gggtggcatc gaggacctt.c ttgcattctc ctgtgggaag 3600
cccagtgcct ttgctcctct gtcctgcct:c tactcccacc cccactacct 3650
ctgggaacca cagctccaca agggggagaa gcagctgggc cagaccgagg 3700
tcacagccac tccaagtcct gccctgcc;~c cctcggcctc tgtcct.ggaa 3750
gccccacccc tttcttcctg tacataatgt cactggcttg ttgggatt.tt 3800
taatttatct tcactcagca ccaag ggccc cggacactcc actcctgca g 3850
cccctgagct gagcagagtc attattggag aqttt.tgtat ttattaaaac 3900
attt.cttttt: cagtcat tgg gcatgagc;ti: ggctcattgt ggccaggaac 3950
cagagtgggg cctggtggag aaggggcr:ga gagtaggagg t.gagagagag 4000
gagctctgac acttggggag ctgaaagaga cctggagagg c:agaggatag 4050
cgtggcnntt. ggctgg~:atn cctgggttcc gcagaggggc tggggatggt 4100
tcttgagatg gtctag-jgac tcaagaattt aggga agtag aagcaggatt 9150
ttgactcaag tttagt'.tcc cac:atcgcag gcctg tttgc tgacttcatg 4200
tttgaagttg ctccagagag agaatca<:ag gtgtcaccag cccctctctc 9250
cctccttccc ttcccttccc tttctttcvcc tcccctcccc tcccctcccc 4300
tcccctcc 9308
<210> 528
<211> 1285
<212> DNA
<213> Homo sapien
<400> 528
ggccgagcgg gggt.gctgcg cggcggccgt gatggctggt= gacggcgggg 50
ccgggcaggg gaccgc;ggcc g<:ggcccggg agcgggccac~ ctgccgggag 100
ccctgaatca ccgccvggcc cgactcc:aCC atgaacgtcg cgctgcagga 150
3h9

CA 02421388 2003-03-25
gctgggagct ggcagcaacg tgggattcc<~ gaaggggaca agacagctrt 200
taggctcacg cacgcagctg gagca ggtcr tagcaggtgc ctctctactg 250
ctggctgcac: tgcttctagg ctgc:cttgtg gccctagggg tccagtacca 300
c.agagaccca tcccacacca cctctccttac agaggcctgc attcgagtgg 350
caggaaaaat cctggagtcc ctggaccgag gggtgagccc c:tgtgaggac 400
ttttaccagt tctcctgtgg gggc~tggat t c:ggaggaacc c:cctgcccga 450
t;gggcgt:tct cgctgga~:zca ccttcaacag cctct<~ggac caaaaccagg 500
ccatactgaa gcacctgcat gaaaacacca c cttcaactc cagcagtgaa 550
gctgagcaga agacacagcg cttctacct:a tcttgcctac aggtggagcg b00
cattgaggag ctgggag~;cc agccactg~:cg agacctcatt gagaagattg 650
gtggttggaa cattacg~:lgg ccctgggacc aggac.=actt tatggaggtg 700
ttgaaggcag r_agcagggac ctacagggcc accccattct tcaccgtcta 750
catcagtgcc gactctaaga gttccaac<sg caatgttatc caggtggacc 800
agtctgggct ctttctgccc tc.tcggga-_t aca acttaaa cagaactgcc 850
aatgagaaag taaggaacat cttccgaac~c cccatcccta cccctggctg 900
agctgggctg atccctgttg acttttcc.~t t:tgccaaggg tcagagcagg 950
gaaggtgagc ctatcctgtc acct<3gtgaa caaactgccc ctcctttc,tt 1000
tcttct.tttc ttcct.ccctc cctccctttc ttcccctttt cctt.cctr_cc 1050
ttcctcttat tcttctagta ggtttcatag acacc;tactg t.gtgcc:aggt 1100
ccagtggggg aattcgqaga t,ata~agtttc cgagccattg ccacaggaag 1150
cgttcagtgt cgatgggttc atggacct ag atagc~ctgat aacaaagctc 1200
acaagagggt cctgaggatt caggagac:ac ttatggagcc agcaaagtct 1250
t:cctgaagag attgca~tta agccaggtcc tgtag X285
<210> 529
<211> 1380
<212> DNA
<21.3> Homo sapiens
<400> 529
atgcctacta ccttccaact aagaatgaga tcgtcttccc cgctggcatc 50
ctgcaggccc ccttctatgc ccgcaaccac cccaaggccc tgaactt.cgg 100
tggcatcggt gtggtcatgg gccatgagtt. gacgcatgcc: tttgatgacc 150
aagggcgcga gtatgacaaa gaagggaacc tgcggccctg gtggcaqaat 200
gagtccca gg cagccttccg gaaccac:acg gcct.gcatgg aggaacagta 250
caatcaatac caggtcaatg gggagaggct caac:ggccgc: cagacgctgg 300
365

CA 02421388 2003-03-25
gggagaacat tgctgacaac ggggggctga aggctgccta c:aatgcttac 350
aaagcatggc tgagaaagca tggggaggag cagcaactgc c:agccgtggg 400
gctcaccaac caccagct ct tctt.cgtgc;g at t.tgc:ccag gtgtggtgc-t. 950
cggtccgcac accagagagc tctcacgac~g ggctggtgac cgacccccac 500
agccctgccc gcttccgc:gt gctgggca< t <:t_ctcc:aact cc:cgt:gactt 550
cctgcg_qcac ttcggctclcc ctgtcggctc ccccatgaac ccagggcagc 600
tgtgtgaggt gtggtagacc: tggatcag~:Ig gagaa,3tggc cagctgtcac: 650
cagacctggg gcagctc=cc: tgacaaag~a gtttgctctt gggttgggag 700
gaagcaaatg caagctgggc tgggtcta~lt ccctcccccc cacaggtgac 750
atgagtacag accctcctca atcac:cacat tgtgcctctg ctttgggggt 800
gcccctgc-ct ccagcagagc ccc-caccatt cactgtgaca tctttccgtg 850
tcaccctgcc tggaagaggt ctgggtgggg aggccagttc ccatagg-<cag 900
gagtctgc.ct cttctgtccc: caggctcact cagccaggcg gccatggggc 950
ctgccgtgcc tgccccactg tgacccacag gcctgggtgg tgtacctcct 1000
ggacttctcc ccaggci.cac tcagtgccca cttaggggtg gactcagctc 1050
tgtctggctc accctcacgg gctaccccvca cctcaccctg tgctccttgt 1100
gccactgctc ccagtgc:tgc tgctgac~wtt c:actgacagc tcctagtgga 1150
agcccaaggg cctctg:~aag cctcctgc:tg ccca~~tgttt c:cctgggctg 1200
agaggggaag tgcatatgtg tagcgggt:ac tggttcctgt g tcttagggc 1250
acaagcctta gcaaatgatt gattctc;:ct. ggacaaagca ggaaagc:aga 1300
tagagcaggg aaaaggaaga ac:agagttta t:.ttttacaga aaagagggtg 1350
ggagggtgtg gtcttggccc ttat:agg,~cc 1380
<210> 530
<211> 39
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence.
<222> 1-39
<223> Artificial :sequence
<400> 530
gaagcagtgc agccaclcagt agagaggcac: ctgct.aaga :39
<210> 531
<211> 29
<212> GNA
<213> Artificial.
36H

CA 02421388 2003-03-25
<220>
<221> Artificial. Sequence
<222~~ I-24
<223> Artificial Sequence
<400> 531
acgcagctgg aactggt~:at agcy 24
<210> 532
<211> 24
<212> DNA
<21.3> Artificial
<22_0>
<221> Artificial Sequence
<222> 1-29
<223> Artificial Sequence
<400> 532
ggtactggac ccctagggcc acaa 24
<210> 533
<211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21
<223> Artificial Sequence.
<400> 533
cctcccagcc gagacc;3gtg g 21
<210> 539
<211> 21
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-21
<223> Artificial ~~equence
<400> 534
ggtcctataa gggcca~agac c 21
<210> 535
<211> 99
<212> DNA
<213> Artificial
<220>
<221> Artificial Sequence
<222> 1-99
<223> Artificial. Sequence
<400> 535
gactagttct agatcgcgag cggccgccct tttttttttt tttt 94
<210> 536
<211=> 16
<212> DNA
367

CA 02421388 2003-03-25
<'213> Artificial
<220>
<221> Artificial Sequence
<222> 1-7.6
W'23> Artificial SPrn »n~P
<900> 536
c.ggacgcgtg ggtcga 16
~''<'10> 537
~211> 21
<212> DNA
W 13> Artificial
<220>
W:21> Artificial Sequence
<222=> 1-21
<223> Artificial Sequence
<400> 537
c:ggccgtgat gqctggtga:v g 21
<210> 538
<211> 20
<212> DNA
<213> Artificial
<220>
<221> Artificial. Sequence
<222> 1-20
<223> Artificial. Sequence
<400> 538
ggcagactcc ttcctatggca 20
_s68

CA 02421388 2003-03-25
DE~IANDES OU BREVETS VOLUl~TINEUX
LA PRESENTE PAR'TIE DE CETTE DEVL~NDE OU CE BREVETS
C01'IPREND PLUS D"UN TO1~IE.
C ECI EST LE T01~IE ~ DE~
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JL' MBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
'THIS IS VOLC,'ME~ OF
NOTE: For additional volumes please contact the Canadian Patent Office.