Note: Descriptions are shown in the official language in which they were submitted.
CA 02534306 2006-O1-30
A NEW COSMETIC COMPOSITION
Field of the invention
The present invention relates to a composition comprising water, optionally
containing
25 - 400ppm of Ag, hydrophobic particles, preferably having a diameter, ranged
from about 5 to
about I50 nm, and/or hydrophilic particles preferably having a diameter,
ranged from about 5 to
about 150 nm and a soluble electrolytic component, capable of releasing free
ions in an aqueous
environment, referred herein to as an electrolyte, wherein when the
concentration of hydrophilic
particles is Owt% then the concentration of hydrophobic particles is >Owt% and
when the
concentration of hydrophobic particles is Owt% then the concentration of
hydrophilic particles is
>Owt%. When the hydrophobic particles are not present in the composition, it
is in a colloid-gel
form and when the hydrophilic particles are not present in the composition, it
is in a colloid-
powder form in which the hydrophobic particles bound shells that encapsulate
aqueous solution
droplets. When hydrophilic and hydrophobic particles are present in the
composition it
simultaneously comprises bounded shells encapsulating a gaseous material,
dispersed in water
and bounded shells encapsulating aqueous solution droplets. Such composition,
according to the
present invention, that presents a characteristic emulsion structure (namely,
the presence of
bounded shells encapsulating gas, coated by an external layer of hydrophilic
particles and an
internal layer of hydrophobic particles), side by side, with a characteristic
powder structure
(namely, the presence of bounded shells encapsulating aqueous solution
droplets, coated by an
external layer of hydrophobic particles and an internal layer of hydrophilic
particles), referred
herein to as a bi-phase composition.
More specifically, a bi-phase composition, according to the present invention,
comprises
a certain proportion of bounded shells encapsulating gas dispersed in
electrolytic solution,
herein referred to as an emulsion phase and bounded shells encapsulating
aqueous solution
droplets, herein referred to as a powder phase. It should be pointed out that
the presence of
electrolyte in the composition of present invention plays a key role in
establishing said unique
bi-phase state.
The composition of present invention represents two forms of powder phases:
(a) The powder phase in a bi-phase composition which comprises water,
hydrophobic
particles, hydrophilic particles and an electrolytic component is represented
by a bounded shell
encapsulating aqueous solution droplets, coated by an external layer of
hydrophobic particles
and an internal layer of hydrophilic particles; and
(b) The powder phase in a composition which comprises water, hydrophobic
particles
and an electrolytic component is represented by a bounded shell encapsulating
aqueous solution
droplets, coated by an external layer of hydrophobic particles.
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The present invention further relates to a topical cosmetic composition
formulated for
concealing wrinkles and for treating and/or improving disorders resulted in
damage to the skin
appearance, including preventing and/or treating a situation of abnormal hair
loss (baldness).
It should be noted that hydrophobic and hydrophilic particles used in the
present
invention have a diameter, preferably in the range from about 5 to about 150
nm. The gaseous
material may be air, ozone, oxygen and/or neutral gas.
Background of the invention
WO 03/049706 the disclosure of which is incorporated herein by reference,
describes an
emulsion comprising water, hydrophilic particles (such as, for example, Si02,
A1203, Ti02,
Fe203 and Mn0) and hydrophobic particles (such as, for example, oxide
particles having
surfaces coated with non-polar, hydrophobic groups), wherein the hydrophilic
and hydrophobic
particles form shells encapsulating a gas that is suspended in the water, said
shells comprising
an external layer of hydrophilic particles and an internal layer of
hydrophobic particles adjacent
to the layer of hydrophilic particles.
WO 03/049706 further describes a powder comprising water, hydrophilic
particles and
hydrophobic particles, wherein the water is encapsulated in shells comprising
an external layer
of hydrophobic particles and an internal layer of hydrophilic particles
adjacent to the layer of
hydrophobic particles.
The concentration of hydrophobic particles in the composition described in WO
03/049706 determines its physical form, namely, in a relatively low
concentration the
composition is in an emulsion form, whereas in a relatively high concentration
the composition
is in a powder form. However, both emulsion and powder forms described in WO
03/049706
represent a mono-phase state since the emulsion form contains bounded shells
encapsulating a
gaseous material, and the powder form contains bounded shells encapsulating
water. Neither
form contains both mentioned bounded shells, side by side, simultaneously.
US Patent 6,808,715, the disclosure of which is incorporated herein by
reference,
describes an emulsion comprising water, hydrophilic particles comprising oxide
particles having
hydrophilic polar groups on their surface (such as, for example, -OH, CaC03,
CuS04 and
CaS04), and hydrophobic particles, wherein the hydrophilic and hydrophobic
particles form
shells as described in WO 03/049706.
The emulsions described in the above mentioned references are useful in
preparation of
topical cosmetic compositions for concealing wrinkles and for treating and/or
improving
disorders resulted in damage to the skin appearance.
Adding an insoluble, crystalline, solid polar ionic compound, such as CaC03,
CuS04
and/or CaS04, to the hydrophilic particles, resulted in increasing and
facilitating the contact
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between the hydrophilic particles that are located externally to the shells in
the emulsion and the
skin. Thus, the various ingredients of the cosmetic composition when applied
to the skin form a
direct contact with the skin surface as a consequence of the presence of polar
crystalline
structure bound to the external layer of the shell.
When applied onto the skin, the above described emulsions and powders may
sometimes suffer from losing of too-much water in a relatively short time
resulted in a rapid
dryness. This dryness phenomenon resulted in reducing the effectiveness of the
topical cosmetic
composition in concealing wrinkles and in treating and/or improving disorders
leading to
damage to skin appearance. The relatively large evaporative surface area of
the nanoparticles
plays a significant role in increasing water evaporation, even at the storage
state, resulted in
shortening the composition's shelf life. Consequently, for preparing a desired
cosmetic
composition having both, longer shelf life and prolonged operation time, some
additional means
are required for increasing and/or stabilizing the attraction forces between
the hydrophobic
particles and water and between the hydrophobic particles and hydrophilic
particles, when the
latter are present. Such means should reduce the loss of water from said
cosmetic composition.
It was surprisingly found that addition of a soluble electrolytic component,
capable of
releasing free ions in an aqueous environment, referred herein to as an
electrolyte, to the
emulsions and powders described hereinabove, resulted in production of a
stable, prolonged
release cosmetic composition that shows a substantial improvement in
concealing wrinkles and
in treating disorders leading to damage in skin appearance, including abnormal
hair loss
(baldness). The role of the electrolyte in the composition of present
invention is to provide free
ions for increasing the electrostatic and ionic forces between the water and
the hydrophobic and
hydrophilic particles, resulted in reducing the loss of water phenomenon.
Furthermore, it was
found that in many cases, the added electrolyte, may substitute the
hydrophilic particles. In such
cases, hydrophobic particles attract negative ions from the aqueous
environment resulted in
creating a water-diffusible layer on the surface of the hydrophobic particles.
Substitution of
hydrophilic particles by electrolyte means that no water in the prepared
powder is bound to
hydrophilic particles to form a gel-like structure. Consequently, a
substantial increase in the
amount of "free" water in the powder forms is obtainable as a result of using
electrolyte for
substituting hydrophilic particles, according to the present invention. Thus,
a colloid-powder
composition comprising water, hydrophobic particles, preferably having a
diameter in the range
of 5-150nm, and an electrolyte is formed, according to the present invention,
and is very useful
in preparing a fully active cosmetic composition formulated for concealing
wrinkles and for
treating and/or improving other disorders in the skin appearance, including
abnormal hair loss
(baldness). It should be emphasized that skin-care ingredients dispersed in
"free" water show
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CA 02534306 2006-O1-30
higher activity and effectiveness compared to the same ingredients when
dispersed in bounded
water, having ice-like structure with low molecular mobility,
The electrolyte in the composition of present invention plays a key role in
the creation
of a bi-phase state, namely the presence of bounded shells encapsulating a
gaseous material side
by side with bounded shells encapsulating aqueous solution droplets. The
proportion of each
type of shell in the composition is dependable by the concentrations of
hydrophobic and
hydrophilic particles as well as the electrolyte. Consequently, it is possible
to monitor the
amount of each type of shell by controlling the concentration of composition's
particles and
electrolyte.
It should be pointed out that when the composition of present invention
comprises
hydrophobic particles and electrolyte (no hydrophilic particles are present)
it is considered a
mono-phase composition having only one type of bounded shells, namely shells
that encapsulate
aqueous solution droplets. The addition of hydrophilic particles to the
composition resulted in
the formation of a bi-phase state in which both types of shells (the one that
encapsulates a
gaseous material and the one that encapsulates aqueous solution droplets) are
present. The
electrolyte in the composition of present invention provides free soluble ions
that strengthen the
links between water, hydrophilic and hydrophobic particles resulted in the
stabilization of both
types of shells presented in the bi-phase state.
The use of electrolyte in an emulsion and/or powder forms of composition,
according to
the present invention, provides a prolonged release, highly effective cosmetic
composition
having increased shelf life. In addition, in many cases, the presence of
electrolytes in the
cosmetic composition avoids the need of addition of other stabilizing and/or
preservative agents.
A metal oxide hydrophilic particle, such as, for example A1203, Ti02, Fe203 or
Mn0
is considered a relatively more positively-charged particle, compared to the
non-metal oxide
hydrophilic particle, such as, for example, SiOz. More specifically, the
positively-charged metal
of the metal oxide hydrophilic particle may attract negatively-charged ions,
whereas the
negatively-charged oxygen of both, metal and non-metal oxide hydrophilic
particles may attract
positively-charged ions present in the medium. Consequently, a combination of
metal and non-
metal oxide hydrophilic particles in the composition of present invention is
correspondingly
resulted in association of the particles with both negatively- and positively-
charged ions present
in the medium.
It is known that addition of increasing amounts of electrolyte to water
resulted in
shifting pH values towards the alkaline range (pH>7). In view of this fact, it
was surprisingly
found that adding increasing amounts of electrolyte, such as, for example,
NaCI to a system
comprising water, hydrophobic particles, such as, for example, hydrophobic
silica nanoparticles
and hydrophilic particles, such as, for example, hydrophilic silica
nanoparticles retains the pH of
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the system on the acidic side (pH<7). More specifically, one would predict
that addition of
increasing amounts of electrolyte to such system will result in dramatically
changes in pH
values, from the acidic side (pH<7) to the alkaline side (pH>7). However, the
presence of
hydrophilic particles in the composition of present invention resulted in
producing a buffering
environment that allows insertion of high concentrations of electrolyte
without significantly
affecting the pH. Taking into consideration that the electrolyte in the
composition of present
invention plays an important role in stabilizing the composition and enhancing
its biological
effectiveness, this pH buffering capability has a great advantage in preparing
cosmetic
compositions, which contain high concentrations of electrolyte.
Summary of the Invention
It is an object of present invention to provide a stabilized, prolonged
release highly
biologically active topical cosmetic composition formulated for concealing
wrinkles and for
treating and/or improving disorders resulted in damage to the skin appearance,
including
preventing and/or treating a situation of abnormal hair loss (baldness).
It is a further object of present invention to provide a composition
comprising water,
optionally containing 25 - 400ppm of Ag, hydrophobic particles, preferably
having a diameter,
ranged from about 5 to about 150 nm and/or hydrophilic particles preferably
having a diameter,
ranged from about S to about 150 nm and a soluble electrolytic component,
capable of releasing
free ions in an aqueous environment, referred to as an electrolyte, wherein
when the
concentration of hydrophilic particles is Owt% then the concentration of
hydrophobic particles is
>Owt% and when the concentration of hydrophobic particles is Owt% then the
concentration of
hydrophilic particles is >Owt%.
It is a further object of present invention to provide a colloid-gel stable
composition
comprising water, optionally containing 25 - 400ppm of Ag, hydrophilic
particles, preferably
having a diameter in the range of S-1 SO nm, and an electrolyte.
It is a further object of present invention to provide a stable, colloid-
powder
composition that comprises water, optionally containing 25 - 400ppm of Ag,
hydrophobic
particles, preferably having a diameter in the range of 5-I SOnm, and an
electrolyte, wherein the
hydrophobic particles bounding shells that encapsulate aqueous solution
droplets.
The ions derived from the electrolytic component are associated with formation
of
strong electrostatic, ionic forces between the water and the hydrophobic
particles, resulted in
decreasing the amount of evaporable and/or removable free water from the
composition.
Consequently, such composition retains its water content to a longer period,
avoiding any
potential rapid dryness of the water encapsulated in the shells. Optionally,
the hydrophobic
particles may be partially, or entirely, coated by an amphiphilic substance
(containing both
CA 02534306 2006-O1-30
hydrophilic and hydrophobic groups) to form a stable composition in which the
water, soluble
electrolyte and other effective skin-care components, such as, for example,
essential oils, are
located internally and externally to the shells encapsulated by a layer of the
amphiphilicly-
coated hydrophobic particles. Such composition of present invention may be
highly effective in
the treatment of a combination of disorders in skin appearance.
It is yet a further object of present invention to provide a bi-phase
composition
comprising water, optionally containing 25 - 400ppm of Ag, hydrophobic and
hydrophilic
particles, preferably having a diameter, ranged from about 5 to about 150nm,
and an electrolyte,
wherein such composition comprises simultaneously, bounded shells
encapsulating a gaseous
material, dispersed in water, side by side with bounded shells encapsulating
aqueous solution
droplets.
The electrolyte in such composition plays a key role in establishing the said
unique bi-
phase state. It releases ions that form strong electrostatic and ionic forces
between the water and
the hydrophobic particles and between the hydrophilic particles and
hydrophobic particles.
Consequently, the insertion of electrolyte into the composition, according to
present invention,
provides soluble free ions that function in stabilization of both types of
shells existing in said bi-
phase composition.
It is assumed that in this case the electrolyte stabilizes the shells of both
the emulsion
structure and the powder structure that exist in the bi-phase water-containing
composition by
increasing the affinity and the electrical attraction forces between the
hydrophobic and
hydrophilic particles and water.
It is yet a further object of present invention to provide a composition
comprising water,
optionally containing 25 - 400ppm of Ag, hydrophilic particles, preferably
having a diameter,
ranged from about 5 to about I SOnm, an electrolyte, and an insoluble,
crystalline, solid polar
ionic compound, such as CaC03, CuS04 and/or CaS04, adsorbed on the surface of
the
hydrophilic particles. Hydrophobic particles, preferably having a diameter,
ranged from about 5
to about 150nm, are optionally present in said composition.
The insoluble ionic compounds when adsorbed on the surface of a hydrophilic
particle
form a layer containing a large amount of sharp protrusions that increase and
facilitate the
contact between the hydrophilic particle and the skin. It further facilitates
the direct contact of
the various ingredients present in such cosmetic composition with the skin. It
is estimated that
these insoluble ionic compounds when adsorbed onto the surface of hydrophilic
nanoparticle
form a complex that provides a high electrical field having catalytic
properties as well as strong
polarization effect capable of attracting even non-polar substances present in
the skin, such as,
for example, fats and pus. The highly efficient anti-bacterial suppression
effect of such
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composition of present invention should attributable to the formation of said
complex when
non-soluble ionic compounds are adsorbed on the surface of hydrophilic
nanoparticle.
A further object of present invention is the preparation of a topical cosmetic
formulation
for concealing wrinkles and for treating and/or improving other disorders in
skin appearance,
such as, for example, acne, psoriasis, seborrhea, skin pigmentation,
cellulitis, herpes, wound
disinfection, skin fungus, skin irritation, allergies of the skin, eczema,
atopic dermatitis, alopecia
and warts, using any of the compositions discussed above.
Description of the invention
The topical cosmetic composition, according to the present invention,
comprises water,
optionally containing 25 - 400ppm of Ag, hydrophobic particles, preferably
having a diameter,
ranged from about 5 to about I50 nm, and/or hydrophilic particles preferably
having a diameter,
ranged from about 5 to about 150 nm and an electrolyte, wherein when the
concentration of
hydrophilic particles is Owt% then the concentration of hydrophobic particles
is >Owt% and
when the concentration of hydrophobic particles is Owt% then the concentration
of hydrophilic
particles is >Owt%. This composition is specifically formulated for concealing
wrinkles and for
treating and/or improving other disorders resulted in damage to the skin
appearance, including
hair loss. Such topical composition, according to the present invention, may
contain additional
conventional and/or non-conventional ingredients beneficial for skin care, for
example an oil,
such as, sea buckthorn oil, primrose oil, almond oii and tea tree oil, vitamin
A, beta carotene,
vitamin E, vitamin C, anti-oxidants, anti-radicals, hydroxy-carboxylic acids,
such as, for
example octylhydroxy stearate, octylhydroxy acetate and salicylic acid,
carboxylic acids, such
as citric acid, propylene glycol, Fulvic acid, benzoyl peroxide, etc.
The topical cosmetic composition of the present invention may be in the form
of lotion,
cream, paste, ointment, gel, aerosol and powder.
The type, size, specific surface (in terms of m2/gr) and concentration of
hydrophobic
and hydrophilic particles in emulsion and powder forms of the composition of
present invention
are described in WO 03/049706 and US Patent 6,808,715. The gaseous material
used in the
emulsion of present invention is described in these references, as well.
The electrolyte used according to the present invention, may release in an
aqueous
environment a monovalent ion, a divalent ion, a multivalent ion or a mixture
thereof.
A monovalent electrolyte may be represented by any soluble salt which releases
free
monovalent ions in aqueous environment, such as, for example, NaCI, KC1, LiCI,
NaN03,
CH3COONa, CH3COOAg, lactic acid salt.
A divalent electrolyte may be represented by any soluble salt which releases
free
divalent ions and/or a mixture of free divalent and monovalent ions in aqueous
environment,
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such as, for example, CaCl2, MgCl2, Epsom salt (MgS04~7H20), Ca(N03)2,
(CH3CO0)ZMg,
ZnS04, (CH3C00)ZZn and a metal salt of dicaboxylic acids.
A trivalent electrolyte may be represented by any soluble salt which releases
free
trivalent ions and/or a mixture of free trivalent, divalent and monovalent
ions in aqueous
environment, such as, for example, FeCl3 and metal salts of tricarboxylic
acids.
Any mixture of electrolytes, such as, for example, the Dead Sea salt
(comprising a
mixture of MgClz 33%, KCI 25%, NaCI 5.7% and CaCl2 0.3%) and any commercial
biological
active product containing salts or minerals that release ions in an aqueous
environment, such as,
for example, "Fulvic Acid Mineral Water" (by Springboard), is within the scope
of present
invention, as well.
An organic divalent- or multivalent ion [for example, the anions derived from
di- and tri
carboxylic acids, such as, succinic, gluconic, uric and citric acids and/or
organic cations derived,
for example, from di- and multi- amines and/or polar amphoteric molecule in a
hybrid ions state
(Zwitterion), for example an amino acid], form a linking bridge between
similar and/or different
hydrophobic nanoparticles, between hydrophobic and hydrophilic particles and
between
hydrophobic particles and water to yield a higher stabilized composition in
either mono-phase or
bi-phase state and consequently, provides a substantially more effective
prolonged release
topical cosmetic composition having longer shelf life. Linking bridges may
establish a well
interconnected system showing a lower rate of water evaporation. More
specifically, forming
linking bridges may reduce the water evaporation by 10 to 100 fold. This
reduction in
evaporation plays an extremely important role in establishing the stable, long
lasting, highly
effective cosmetic composition of the present invention.
WO 03/049706 and US Patent 6,808,715 describe the various cosmetic
applications of
(1) emulsion which comprises water, hydrophobic and hydrophilic particles,
preferably having a
diameter in the range of 5-150 nm, wherein the hydrophobic and hydrophilic
particles form
shells encapsulating a gaseous material that is suspended in the water; said
shells comprising an
external layer of hydrophilic particles and an internal layer of hydrophobic
particles adjacent to
the layer of hydrophilic particles; and of (2) powder which comprises water,
hydrophobic and
hydrophilic particles, preferably having a diameter in the range of 5-150 nm,
wherein the water
is encapsulated in shells comprising an external layer of hydrophobic
particles and an internal
layer of hydrophilic particles adjacent to the Layer of hydrophobic particles.
Using the cosmetic composition, according to the present invention, which
comprises water, hydrophobic particles, preferably having a diameter, ranged
from about 5 to
about 150 nm, and/or hydrophilic particles preferably having a diameter,
ranged from about 5 to
about 150 nm and an electrolyte, wherein when the concentration of hydrophilic
particles is
Owt% then the concentration of hydrophobic particles is >Owt% and when the
concentration of
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hydrophobic particles is Owt% then the concentration of hydrophilic particles
is >Owt% may
result in increasing, enhancing and facilitating one or more of the following
biological effects
associated with skin care activity:
~ Reduction and/or removing wrinkles by straightening the wrinkled skin,
flattening the
furrows and making the wrinkles invisible and less pronounced. Flattering
wrinkles
furrows, reduces the pressure on blood capillaries network, resulted in
restoring of
normal blood supply.
~ Skin reinforcement and rejuvenation:
Due to the presence of electrolyte in the composition of present invention, it
forms a
stable layer when applied onto the skin surface. Said layer which consists of
a stabilized
nanoparticles network is strongly anchored to the skin and may be effective
for several
hours, if so desired. The relatively long lasting, stable network structure
reinforces the
treated skin area, inter alia, by unfolding the folded intracellular capillary
vessels
resulted in an enhancement and/or increasing of blood supply to the treated
skin region,
thus providing the important rejuvenation effect
~ Skin complexion improvement:
As was explained here-in-before, the presence of electrolyte in the
composition of
present invention, provides a stable, long lasting skin-care effective
composition. When
such composition is applied onto the skin surface, it forms a white,
stabilized
nanoparticles network which is strongly anchored to the skin and may stay in
contact for
several hours, if so desired. This white nanoparticles network provides a skin
whitening
effect, resulted in improving skin complexion.
~ Moisturizing skin
~ Antioxidant effect
~ Skin cleaning (cleansers)
~ Soft peeling:
Soft peeling function of the composition of present invention resulted in
removing
impurities, scales and dead cells from treated skin surface, thus eliminating
the favored
natural environment required for fungi and bacteria growth.
~ Bio-stimulation:
The electrolyte present in the composition of present invention plays an
important role
in stimulating biological processes leading to renewal and/or recovery of
damaged skin
functions and/or appearance. The ions derived from the electrolyte are
involved with
and enhance a wide range of biological processes associated with the recovery
of
damaged skin, such as restoring capillary blood flow, cleansing, reinforcing
and self
healing. 1n addition, said ions are associated with other skin care
activities, such as:
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CA 02534306 2006-O1-30
o Maintaining buffering environment for keeping unchanged the desired pH on
the treated skin surface.
o Redistributing electrolytes and/or ions between skin pores, capillaries,
wounds
and regular tissue surface to renew the desired net of typical periodic
electric potential
that is characteristic to normal healthy skin.
o Maintaining electric polarization effect which accelerates skin cellular
activity.
o Facilitating the transformation of the composition of present invention,
which
consists of 3-dimensional colloidal nanoparticles system into a stable, long
lasting, self
organized 2-dimentional network tightly anchored to the skin surface. Such
transformation occurred when the composition is applied onto the skin surface
and it is
followed by the release into the skin of valuable skin-care ingredients. It
should be
mentioned that the ions present in the 2-dimensional network play a key role
in
controlling the release of skin-care ingredients and nutritional factors and
in their
penetration into the skin. Thus, the ions derived from the electrolyte play a
significant
role in the stabilization of the 2-dimensional network that covers and coats
the skin.
Consequently, they directly affect and control the prolonged release process
of
components and ingredients from the composition of present invention, when it
is
applied onto the skin surface.
~ Anti-inflammatory effect.
~ Soothing of irritated skin:
The electrolyte which is present in the composition of present invention
provides ions
that upon application of the composition onto the skin surface produce a net
of electric
potentials causing the skin surface nerves to reduce their sensitivity. At the
same time,
some anti-inflammatory agents such as, for example, sea buckthorn oil and/or
tea tree
oil, are slowly released to provide long lasting skin soothing and anti-
irritation effects.
Thus, the composition of present invention when applied onto the skin surface
produce
a thin coating layer (which may be invisible, if so desired) which functions
as a bandage
having, inter alia, skin soothing and anti-irritation properties.
~ Anti-ageing effect:
The anti-oxidation activity of the composition of present invention, as well
as its
function in deactivation of free radicals play a critical role in forming a
prominent anti-
aging effect. More specifically, the composition found highly effective in
removing
from the treated skin zone dead cells, free radicals, toxins and other
impurities having
aging effect.
The cosmetic composition of present invention practically represents a
structure
consisting of a huge number of tiny particles, specifically arranged in
aggregates, partially
CA 02534306 2006-O1-30
interconnected with soluble ions, which in the mono-phase state it contains
either shells
encapsulating gas and/or vaporized water (an emulsion structure or phase), or
it contains shells
encapsulating aqueous solution droplets (a powder structure or phase) and in
the bi-phase state it
contains both emulsion and powder structures (or phases), represented by the
corresponding
types of shells.
The electrolyte used according to the present invention plays a double role: (
1 ) in
stabilization of specifically designed emulsion or powder structure of the
mono-phase cosmetic
composition and in formation of the characteristic structure of bi-phase
cosmetic composition
which comprises simultaneously, side by side, both emulsion and powder
structures; and (2) in
facilitating and enhancing the favorable effects of ions on skin functions and
appearance.
Consequently, the cosmetic composition of present invention is highly
effective as skin cleanser
that removes dead cells and toxins from the skin nourishes and polishes it,
and in many cases,
repairs damage to skin functions and appearance originated from the
accumulation of dead cells
and/or toxins.
The electrolyte in the cosmetic composition of present invention is further
associated in
facilitating the important antioxidant effect of such composition.
It was further found that the presence of electrolyte in the cosmetic
composition of present
invention significantly accelerates the skin recovery from radiation damages
that generate free
radicals and cause burns and skin inflammations. It is assumed that the ions
released from the
electrolyte may restore electrical balance of damaged skin cells. Said ions
may further act in a
process of neutralization of free radicals and other harmful materials, such
as toxins.
The cosmetic composition of present invention significantly accelerates the
skin
recovery process. For example, application of the composition for treating
burns and/or
following hair removal (inter alia by a laser based procedure) resulted in a
full skin recovery
within one week, while it usually takes 2-2.5 weeks. It is assumed that the
composition of
present invention functions as a buffer preventing further acidification of
burns region and at the
same time enhances capillary blood flow resulted in a recovery of damaged skin
tissue.
The electrolyte used in the topical cosmetic composition of present invention,
releases
ions that play an important role in protecting the treated skin from bacterial
and/or viral attack.
In this respect, the cosmetic composition of present invention may be
considered as an anti-
viral, anti-bacterial composition.
WO 03/049706 and US Patent 6,808,715 describe the mode of operation of a
cosmetic
composition consisting of an emulsion or powder comprising water, hydrophobic
and
hydrophilic particles. More specifically, these references relate to the mode
of operation of said
cosmetic composition which when applied onto the skin surface forms a layer
consisting of
network of filaments made of a particular combination of hydrophilic and
hydrophobic particles.
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A portion of the hydrophilic particles migrates towards the sweat gland ducts
located in the skin,
forming tendrils of hydrophilic particles that penetrate into the ducts. A
portion of the
hydrophobic particles migrates and penetrates the ducts of sebaceous glands
located in hair
follicles inside the skin, forming tendrils of hydrophobic particles that
protrude into the hair
follicles and ducts of corresponding sebaceous glands. In particular, the
hydrophilic and
hydrophobic tendrils protrude into ducts of sweat and sebaceous glands that
are located in
furrows of wrinkles in the treated skin region.
Applying the cosmetic composition of present invention for reduction and/or
removing wrinkles comprising the steps of straightening the wrinkled skin,
flattening
the furrows and making the wrinkles invisible or less pronounced. More
particularly, the
cosmetic composition when applied onto the skin surface forms a layer coating
the
region containing furrows of wrinkles. Such layer consists of network of
filaments that
are made of hydrophobic and/or hydrophilic particles. The network which is
strongly
anchored onto the skin surface covers the furrows of wrinkles. The conversion
of three-
dimensional composition structure into two-dimensional structure is followed
by
breaking and opening the shells resulted in releasing gas and water, by means
of
evaporation and/or water flow into the skin. This process is followed by
increasing
attraction forces between particles constructing the network filaments
resulted in
contraction of filaments and subsequently the entire network.
The contraction of the network filaments resulted, inter alia, in flattening
the
furrows of wrinkles, making them invisible or less pronounced. It is
speculated that
during the contraction, the furrows of wrinkles are mechanically pulled out,
thereby
smoothing the skin and drawing the skin taut. The presence of an electrolyte
in the
cosmetic composition of present invention is resulted in the formation of
stronger links
between the same and/or different hydrophobic particles, between hydrophobic
particles
and the surrounding water, between the same and/or different hydrophilic
particles,
between hydrophobic particles and hydrophilic particles and between
hydrophilic
particles and the surrounding water. Consequently, a controlled slow-release
effect of
ingredients present in the cosmetic composition of present invention is
obtainable.
The presence of a well controlled concentration of electrolyte in the cosmetic
composition of the present invention, leads to the formation of two major
types of compositions:
1. A hypotonic composition which directs the free water to flow towards and
inward the
skin, resulted in skin hydration effect; and
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CA 02534306 2006-O1-30
2. A hypertonic composition which pumps the water outward of skin, resulted in
a skin
dehydration effect.
It is clear that hypotonic composition comprises a relatively low
concentration of
electrolyte, whereas the hypertonic composition comprises a relatively high
concentration of
electrolyte. The composition of present invention comprises electrolyte in a
wide range of
concentrations, for example, from >Owt% to about 30wt% and preferably from
O.lwt% to about
20wt%. The concentration of electrolyte in hypotonic cosmetic composition is
ranged from
>Owt% to about lwt% and preferably from about O.lwt% to about O.Swt% and it is
dependable
on the electrolyte used. For example, for NaCI, it is ranged from a
concentration of >Owt% to a
concentration of about 0.7wt% and preferably, from O.lwt% to about 0.5 wt%.
For ZnS04 it is
from >Owt% to about 0.6wt% and preferably, from about O.lwt% to about 0.4wt%.
The
concentration of electrolyte in hypertonic cosmetic composition is >Iwt%,
preferably from
about 2wt% to about 20wt% and most preferably, from about l3wt% to about 20wt%
when
sodium chloride is used and from about 8wt% to about 20wt% when zinc sulphate
is used. In
terms of molar concentrations the hypotonic composition may comprise from >OM
to about
0.1 M sodium and potassium salts and hypertonic composition may comprise from
about 0.1 SM
to about 3.SM of the same salts.
Hypotonic compositions of present invention play an important role, for
example, in
peeling off dead skin cells from the epidermis. As a result of hypotonic
concentration of
electrolyte, water, ingredients and particles are moved from the cosmetic
composition into the
treated skin area to penetrate between dead skin cells and the surface of the
epidermis.
In case of wet skin surface, water and predominantly hydrophilic particles
intend to penetrate
and accumulate between the dead skin cells and the epidermis. In case of oily
skin surface,
water and predominantly hydrophobic particles intend to penetrate and
accumulate between the
dead skin cells and the epidermis. When the dead skin cells are dry, water
from the cosmetic
composition will flow into the dead cells causing them to swell. The
penetration of water into
the dead cells and accumulation of the hydrophobic and/or hydrophilic
particles between
swelled dead skin cells and the epidermis resulted in mechanical pushing out
and dislodging the
dead skin cells from the epidermis. It should be emphasized that swelling dry
dead skin cells by
a hypotonic cosmetic composition, as itself, plays an important role in
mechanically dislodging
dead skin cells from the epidermis. The removal of dislodged dead skin cells
from the skin,
provides a soft peeling effect resulted in a significant improvement in skin
elasticity and
appearance.
Hypertonic cosmetic composition, according to the present invention, is
useful, for
example, in removing toxins and/or other undesired soluble materials
accumulated in the
interstitial fluids. When such cosmetic composition is in contact with the
skin surface, liquids
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CA 02534306 2006-O1-30
are moving from interstitial routes in the skin outwardly towards the applied
cosmetic
composition. The moved liquids may contain toxins and/or other solved
undesired materials
which eventually removed from the skin surface.
The composition of present invention may be useful in treatment of skin
disorders, such
as, for example, acne, psoriasis, seborrhea, skin pigmentation, cellulites,
herpes, wound
disinfection, skin fungus, skin irritation, allergies of the skin, eczema,
atopic dermatitis, alopecia
and warts.
In particular, it was found highly effective in treating oily, acne-prone skin
due its
prominent role in elimination of secondary infections, softening the skin,
peeling the
contaminated epidermis and improving blood circulation. It is further highly
active in
preventing or treating seborrhea, in absorbing infected secretions and drying
up pimples. Acne
is a product of inflamed sebaceous glands forming a plaque of fatty materials
that prevent free
flow of fluids. When the composition of present invention is applied onto the
acne region, it
provides ions associated-hydrophobic and hydrophilic (when present)
nanoparticles that may
favorably affect the damaged skin - as follows:
( 1 ) Opening and/or removing the plaque of fatty materials from follicles
(pores) to
allow free flow of sebum oil to the surface. More specifically, in view of the
high affinity exists
between ions associated-hydrophobic nanoparticles provided by the composition
of present
invention and the fatty materials that form the plaque, the later are removed
off the plaque. As a
result, the plaque disintegrated and disappeared. Consequently, this operation
keeps the follicles
(pores) open and prevents the bacterial growth (resulted in inflammation) and
subsequently the
development of whiteheads and blackheads on the skin surface.
(2) The ions associated-hydrophobic nanoparticles provided by the composition
of
present invention may function in exchanging ions associated with fatty
materials, resulted in
inflammation suppression.
Acne treatment may combine a procedure applying both, hypotonic and hypertonic
compositions of the present invention. Applying hypotonic composition onto the
acne zone
causes flow of water from the composition towards and inwards the treated skin
resulted in
softening and moisturizing the treated acne zone. This is followed by the
expansion of skin
cells. The hypertonic composition that apply to the acne zone successively,
causes a flow of
water from the treated skin towards the composition layer removing from the
treated acne zone
dead cells, toxins and other undesired impurities. This sequential procedure
(namely, successive
applications of hypotonic and hypertonic compositions of present invention)
may be repeated
several times for better draining of sebaceous glands and preventing further
development of
inflammation. It should be noted that this procedure is effective for opening
and cleaning both,
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CA 02534306 2006-O1-30
the blackheads and whiteheads. The electrolyte present in the composition of
present invention
reduces the comedones oil's melting point and thus plays a key role in
decreasing its viscosity.
It should be emphasized that the composition of present invention may be used
for
restoring the natural body healing resources in a procedure of skin treatment
following disorders
such as, canker sores, hives, picking, rosacea, scratching, shingles,
vitiligo, warts, burns,
dermatoses, itching and cholestasis.
Description of the Figures
Fig. 1 represents a graph of actual composition's density in an increasing
concentration
of electrolyte.
Measured density values are represented by points.
The bi-phase composition comprises 2.Swt% hydrophobic silica nanoparticles,
7.Swt%
hydrophilic silica nanoparticles and a variable concentration of Dead Sea salt
(0-30wt%).
Fig. 2 represents a graph of actual composition's porosity in an increasing
concentration
of electrolyte. The bi-phase composition is as described in Fig. I .
Fig. 3 represents a graph of actual composition's pH in an increasing
concentration of
electrolyte.
Measured pH values are represented by points.
The bi-phase composition is as described in Fig. 1.
Fig.4 represents a graph of actual saline solution's pH in an increasing
concentration of
Dead Sea salt.
Fig. 5 represents a graph of actual composition's density in an increasing
concentration
of electrolyte.
Measured density values are represented by points.
The bi-phase composition comprises Swt% hydrophobic silica nanoparticles, Swt%
hydrophilic silica nanoparticles and a variable concentration of Dead Sea salt
(0-30wt%).
Fig. 6 represents a graph of actual composition's porosity in an increasing
concentration
of electrolyte. The bi-phase composition is as described in Fig. S.
Fig. 7 represents a graph of actual composition's pH in an increasing
concentration of
electrolyte. The bi-phase composition is as described in Fig. 5.
Fig. 8 represents a graph of actual composition's density in an increasing
concentration
of electrolyte.
Measured density values are represented by points.
The mono-phase composition comprises Swt% hydrophobic silica nanoparticles,
Owt%
hydrophilic silica nanoparticles and a variable concentration of Dead Sea salt
(0-30wt%).
CA 02534306 2006-O1-30
Fig. 9 represents a graph of actual composition's pH in an increasing
concentration of
electrolyte. The mono-phase composition is as described in Fig. 8.
Examples
Example 1
The composition's density and porosity are dependable on the concentration of
the
electrolyte.
For determination of composition's density it is necessary to calculate the
bulk density
of the composition (gas pores are not included). In the first step, the
density of the saline
solution is determined. This can be done experimentally - as follows:
Dead Sea salt (a commercial product comprising: MgCIZ 33%, KCI 25%, NaCI 5.7%,
CaCl2
0.3% and water 36%), for example, is dissolved in pure water and the
solution's density (g/ml) is
determined for a range of salt concentrations from 0 to 30 wt%. There is a
linear correlation
between saline solution density and the different concentrations of inserted
salt.
The saline solution density is determined using the following regression
Equation:
Saline Solution Density (SSD) in g/ml = 1+3.257x10-3 C
wherein C represents salt concentration (wt%).
For describing the determination of bulk density of the composition of present
invention, a series of compositions comprising 2.5 - 5% (by composition wt) of
silica
hydrophobic nanoparticles and 0 - 7.5% (by composition wt) of hydrophilic
nanoparticles
suspended in water containing Dead Sea salts in concentrations ranged from 0
to about 30% of
water wt.
For the sake of demonstration, a reference is made to a 100g composition
containing
90g of saline solution and total of lOg of hydrophobic and hydrophilic
nanoparticles.
Taking into account that bulk density of silica is 2.65 g/ml, it is possible
to calculate the
bulk volume of silica:
Bulk volume of silica (ml) =l Og/2.65g/ml = 3.774 ml
Saline solution volume can be calculated, as well:
Saline solution volume (ml) = 90g/SSD g/ml
wherein SSD stands for saline solution density.
The total volume of liquid and bulk (excluding gas pores) in the composition
is
calculated by the equation:
Total volume of liquid and bulk (ml) = 90g/SSD + 3.774
Consequently, the bulk density of the composition can be calculated:
Bulk density (g/ml) = 100g/Total volume of liquid and bulk
It should be pointed out that in this case there is a linear correlation
between
composition's bulk density and the different concentrations of inserted salt.
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CA 02534306 2006-O1-30
The porosity of the composition of present invention can be calculated, as
follows:
Porosity = 1 - Actual density/Bulk density
The following examples deal with the determination of actual density and
porosity of a
series of compositions:
Case 1:
The composition comprises 2.5 wt% hydrophobic silica nanoparticles and 7.5 wt%
hydrophilic silica nanoparticles.
This is a typical bi-phase composition that comprises both structures of
shells: the
emulsion structure (namely, the presence of bounded shells encapsulating gas,
coated by an
external layer of hydrophilic particles and an internal layer of hydrophobic
particles) and the
powder structure (namely, the presence of bounded shells encapsulating water,
coated by an
external layer of hydrophobic particles and an internal layer of hydrophilic
particles). In
addition, it comprises a relatively large amount of hydrophilic nanoparticles
that are not
associated with any shell structure, herein referred to as "free" hydrophilic
particles. The
proportion of shells of emulsion structure to the ones of the powder structure
is dependable on
concentration of electrolyte in the composition. The amount of hydrophilic
particles that are not
associated with shells ("free" hydrophilic particles) is about two-thirds of
the total amount of
hydrophilic nanoparticles.
Such a bi-phase composition that represents an excess of "free" hydrophilic
nanoparticles shows some unique features, as shown in Figs. 1-3.
Fig. 1 represents the actual composition's density for each concentration of
added salt up
to 30wt%. The graph shows that a concentration of Dead Sea salt in the range
between about
1 Owt% and about 25 wt% does not affect the density of the composition.
It is speculated that this is a typical effect of an electrolyte on the
density of such bi-
phase emulsion of present invention, having an excess of hydrophilic
particles. In low
concentrations of electrolyte (<lOwt%), the free ions that are released in an
aqueous
environment function in strengthening the links between "free" hydrophilic
particles and
external layers of shells of either emulsion and/or powder structure on one
side and between the
nanoparticles layers that bound the same shell of either emulsion or powder
structure, on the
other. This ionic effect leads to a partial aggregation of shells, to
reduction of distances between
various shells and to some reduction in shells size, resulted in an increase
in composition's
density. Higher concentrations of salt (10 - 25wt%) function in stabilizing
the ionic links with
no significant effect on the density. Further increase of salt concentration
(>25wt%) is resulted
in an intensive aggregation of shells, in further reduction of distances
between shells as well as
in further reduction in shells size. This leads to a further increase in
composition's density.
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CA 02534306 2006-O1-30
Fig. 2 represents the actual composition's porosity for each concentration of
added salt
up to 30wt%. The graph shows that a concentration of Dead Sea salt in the
range between about
6wt% and about 25wt% does not affect the porosity of the composition.
It is speculated that changes in porosity, as well, are derived from same
typical effect of
an electrolyte on such bi-phase emulsion having an excess of hydrophilic
nanoparticles. Low
concentrations of electrolyte (<IOwt%), lead to a partial aggregation of
shells, to reduction of
distances between shells and to some reduction in shells size. This is
resulted in decreasing
composition's porosity. Higher concentrations of salt (10 - 25wt%) function in
stabilizing the
ionic forces with no significant effect on the porosity. Further increase of
salt concentration
(>25wt%) is resulted in an intensive aggregation of shells in further
reduction of distances
between shells and in further reduction in shells size. This leads to a
further decrease in
composition's porosity.
Fig. 3 represents the effect of salt concentration on the pH of same bi-phase
composition. Addition of up to 30 wt% of Dead Sea salt resulted in slightly
decrease in
composition's pH values.
This is an unexpected finding in view of the fact that addition of Dead Sea
salt to water
resulted in an increase in pH values (cf. Fig. 4). It is speculated that
hydrophilic particles in the
bi-phase composition of present invention play a key role in formation of pH
buffering effect.
The excess of hydrophilic nanoparticles, in the bi-phase composition, as
presented in this case,
leads to formation of a strong pH buffering effect.
Case 2:
The composition comprises Swt% hydrophobic silica nanoparticles and 5 wt%
hydrophilic silica nanoparticles.
This is another case of a bi-phase composition that comprises both structures
of shells:
the emulsion structure and the powder structure. In contrast to previous case
(Case 1 ) the
composition in this case does not comprise a significant amount of free
hydrophilic
nanoparticles that are not associated with any shell structure (only 10-30% of
hydrophilic
nanoparticles are free compared to about 67% in Case 1). The proportion of
shells of emulsion
structure to shells of powder structure is dependable on the concentration of
electrolyte in the
composition. For example, in low concentrations of salt the proportion of
shells of emulsion
structure to the ones of powder structure is 9:1, 1:1 and 1:4 in low, medium
and high
concentrations of salt, respectively.
Such a bi-phase composition that comprises at least 70% of hydrophilic
nanoparticles
being in association with shells and represents either emulsion form (in a low
concentration of
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CA 02534306 2006-O1-30
salt) and/or powder form (in a high concentration of salt) shows different
features, as shown in
Figs. 5-7.
Fig. 5 represents the actual composition's density for each concentration of
added salt up
to 30wt%. The graph shows an ascending linear correlation between the actual
composition's
density and the different concentrations of inserted Dead Sea salt. The non-
linear correlation
shown in Fig. 1 (Case 1) reflects a bi-phase composition in which the amount
of hydrophilic
particles is in excess over the amount of hydrophobic particles. Such
situation maintains a
significant amount of "free" hydrophilic particles that are not associated
with shells of either
emulsion or powder structure. It is estimated that the presence in the bi-
phase composition of a
substantial amount of "free" hydrophilic particles plays a key role in the
formation of non-linear
correlation between composition's density and salt concentration.
Fig. 6 represents the actual composition's porosity for each concentration of
added salt
up to 30wt%. The graph shows a descending linear correlation between the
actual composition's
porosity and the concentrations of inserted Dead Sea salt. The non-linear
correlation shown in
Fig. 2 (Case 1) reflects a bi-phase composition in which the amount of
hydrophilic particles are
in excess over the amount of hydrophobic particles. The discussion made in the
description of
Fig 5, is relevant to this figure, as well.
Fig. 7 represents the effect of salt concentration on the pH of the bi-phase
composition.
Addition of up to Swt% of Dead Sea salt does not significantly affect the
composition's pH
values. The "jump" in pH values from about 4.7 to about 5.3 in a salt
concentration of about
7wt% should be noted.
It is estimated that in low concentrations of salt the composition is mainly
in an
emulsion phase. It comprises very low amount, if at all, of shells of powder
structure (or powder
phase). Upon increasing the concentration of salt the composition is shifted
to the powder form
and the proportion of shells of powder phase is gradually increased. The
shells of powder
structure (or powder phase) appear when salt concentration becomes greater
then a certain
threshold (about 7wt% in present case). At that point, the shells of powder
phase start to
contribute to the measured pH values of the composition. Thus, a "jump" of the
pH values
occurs when the concentration of salt reaches the point in which it is capable
of forming new
shells of powder structure next to the already existing shells of emulsion
structure (or phase).
There is an effect of slight decrease in pH values when salt concentrations
are increased from
about l Owt% to about 20wt%.
Here again, it is speculated that the presence of a sufficient amount of
hydrophilic
nanoparticles in a bi-phase composition, as presented in this case, plays a
key role in the
formation of pH buffering environment.
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CA 02534306 2006-O1-30
Case 3
The composition comprises Swt% hydrophobic silica nanoparticles and no
hydrophilic
silica nanoparticles.
This is a typical composition that solely comprises shells of a powder
structure (or
powder phase) coated by a layer of hydrophobic particles.
In the absence of hydrophilic particles, the composition in this case is in a
"water
powder" form. More specifically, the saline solution droplets are covered by a
layer of
hydrophobic silica nanoparticles. In view of absence of shells of emulsion
structure the term
porosity is not applicable in this particular case.
Fig. 8 represents the actual composition's density for each concentration of
added salt up
to 30wt%. The graph shows an ascending linear correlation between the actual
composition's
density and the concentrations of inserted Dead Sea salt. It is estimated that
the free ions that are
released in an aqueous environment function in strengthening the links between
hydrophobic
particles on one side and between hydrophobic particles and water on the
other. This ionic effect
is resulted in increasing aggregation of shells, in reduction of distances
between shells and in
reduction in shells size.
Fig. 9 represents the effect of salt concentration on the pH of the
composition. An
addition of about lOwt% of Dead Sea salt resulted in an increase of
composition's pH to 7.
Further increase in salt concentration (>10 wt%) resulted in pH values on the
alkaline side. In
the absence of hydrophilic particles the pH buffering effect of the
composition is substantially
reduced.
Example 2
This example deals with the preparation of a composition comprising water,
optionally
containing 25 - 400ppm of Ag, lOwt% silica hydrophilic nanoparticles, 2.Swt%
silica
hydrophobic nanoparticles, Dead Sea salt (1 to 20wt%) and optionally
additional conventional
ingredients.
875g saline solution (containing 1 to 20wt% Dead Sea salt dissolved in
purified water or
dissolved in water containing Ag in an amount of 25-400ppm) and SOg Aerosil
380 (a
commercial product of silica hydrophilic particles, having diameters in the
range of 5-150nm,
produced by Degussa of Germany) are mixed together for about 10 minutes in a
mixer having a
propeller rotating at about 1000rpm (rotations per minute). To the formed gel-
like mixture, 25g
Aerosil 8812 (a commercial product of silica hydrophobic particles, having
diameters in the
range of 5-1 SOnm, produced by Degussa of Germany) are added in three batches:
each batch
which contains about 8.3g is mixed for about 20 minutes at about 1000rpm.
Following the
addition of Aerosil 8812, the mixture is further mixed for about 30 minutes at
1500-1800rpm.
CA 02534306 2006-O1-30
To the formed mixture, SOg Aerosil 380 are added and the mixture is mixed for
about 30
minutes at 1000rpm. The formed mixture is set aside for a period of about 24
hours, during
which it is maintained at a constant temperature of about 20°C and
isolated from mechanical
vibration and shock. Following this "maturation" period, the formed mixture is
ready for
optionally insertion (generally, by mixing for 10 minutes at about SOOrpm) of
one or more skin-
care conventional ingredients such as, for example, evening primrose oil
(EPO), sweet almond
oil, sea buckthorn oil, tea tree oil, Finsolv TN (C,2 - C,5 alkyl benzoate),
octyl hydroxystearate,
salicylic acid, vitamin C, citric acid and benzoyl peroxide.
Air, ozone, oxygen or neutral gas may be suspended in water and encapsulated
within
the composition - as follows:
- Removing gas from purified water;
- While mixing the components during the formation of the composition, it
should be
hermetically sealed from the surrounding atmosphere. The hydrophilic and
hydrophobic
nanoparticles should be inserted into the electrolyte solution by suction with
the chosen gas.
Example 3
This example deals with a composition comprising water, optionally containing
Ag in
an amount of 25-400ppm, IOwt% Aerosil 380 (silica hydrophilic nanoparticle),
2.Swt% Aerosil
R 812 (silica hydrophobic nanoparticles), Dead Sea salt (1 to 20wt%) and
optionally one or
more conventional skin-care and/or anti-acne agent, selected from the group
consisting of
evening primrose oil (EPO), sweet almond oil, sea buckthorn oil, tea tree oil,
Finsolv TN (C,2 -
C,5 alkyl benzoate), octyl hydroxystearate, salicylic acid, vitamin C, citric
acid, azelaic acid,
benzoyl peroxide, zinc acetate and sulphur. Said composition found to be
highly effective in
treating acne. It should be pointed out that the concentration of the salt in
such composition is
determined according to the treated skin type (dried, oily, etc) and the
particular acne type,
grade and state of the treated individual. Compositions containing higher
concentrations of salt
( 10 - 20wt%) are preferred for treating an oily skin and an intensive acne
state.
Example 4
The composition which comprises water, optionally containing Ag in an amount
of 25-
400ppm, Swt% Aerosil 380 (silica hydrophilic nanoparticle), Swt% Aerosil R 812
(silica
hydrophobic nanoparticles), Dead Sea salt (I to 20wt%) and optionally one or
more
conventional skin-care and/or anti-acne agent, as described in Example 3 found
to be highly
effective in treating acne.
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CA 02534306 2006-O1-30
Example 5
The composition which comprises water, optionally containing Ag in an amount
of 25-
400ppm, Swt% Aerosil R 812 (silica hydrophobic nanoparticles), Dead Sea salt (
1 to 20wt%)
and optionally one or more conventional skin-care and/or anti-acne agent, as
described in
Example 3 found to be highly effective in treating acne.
Example 6
This example deals with a composition comprising water, optionally containing
Ag in
an amount of 25-400ppm, IOwt% Aerosil 380 (silica hydrophilic nanoparticle),
2.Swt% Aerosil
R 812 (silica hydrophobic nanoparticles), Dead Sea salt ( 1 to 20wt%) and
optionally one or
more conventional skin-care ingredient, selected from the group consisting of
evening primrose
oil (EPO), sweet almond oil, sea buckthorn oil, tea tree oil, borage oil,
Finsolv TN (C,2 - C,5
alkyl benzoate), octyl hydroxystearate, salicylic acid, vitamin C and citric
acid. Said
composition found to be highly effective in concealing wrinkles and in
treating disorders
resulted in damage to the skin appearance. It should be pointed out that the
concentration of the
salt in such composition is determined according to the treated skin type
(dried, oily, etc).
Compositions containing higher concentrations of salt ( 10 - 20wt%) are
preferred for treating an
oily skin.
Example 6a
The composition of Example 6 comprises l2wt% Dead Sea salt and 2wt% sweet
almond oil.
Example 6b
The composition of Example 6 comprises l6wt% Dead Sea salt and 3wt% evening
primrose oil.
Example 6c
The composition of Example 6 comprises l2wt% Dead Sea salt and 4wt% sea
buckthorn oil.
Example 6d
The composition of Example 6 comprises 8wt% Dead Sea salt and 3wt% Finsolv TN
(C~Z - C~5 alkyl benzoate).
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CA 02534306 2006-O1-30
Example 6e
The composition of Example 6 comprises lwt% Dead Sea salt and 3wt% octyl
hydroxylstearate.
Example 7
This composition deals with a composition comprising water, optionally
containing Ag
in an amount of 25-400ppm, Swt% Aerosil 380 (silica hydrophilic nanoparticle),
Swt% Aerosil
8812 (silica hydrophobic nanoparticles), Dead Sea salt (1 to 20wt%) and
optionally one or more
conventional skin-care ingredient, selected from the group consisting of
Evening primrose oil
(EPO), Sweet almond oil, Sea buckthorn oil, Tea tree oil, borage oil, Finsolv
TN (C,Z - C,5
alkyl benzoate), octyl hydroxystearate, salicylic acid, vitamin C and citric
acid. Said
composition found to be highly effective in concealing wrinkles and in
treating disorders
resulted in damage to the skin appearance. It should be pointed out that the
concentration of the
salt in such composition is determined according to the treated skin type
(dried, oily, etc).
Compositions containing higher concentrations of salt ( I 0 - 20wt%) are
preferred for treating an
oily skin.
Example 8
(A). Hypotonic composition for treating acne
Formulation in wt%
Dead Sea salt 0.2
Zinc sulfate 1
Hydrophobic 5
silica
Hydrophilic 5
silica
Tea tree oil 2
Sea buckthorn 3
oil
Vitamin A 0.1
Vitamin C 1.5
Vitamin E acetate0.1
Methylparaben 0.1
Propylene glycol2
Purified water 80%
The water may contain 25 - 400
optionally ppm of Ag.
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CA 02534306 2006-O1-30
(B). Iiypertonic composition for treating acne
Formulation in wt%:
Dead Sea salt 14
Zinc sulfate 6
Hydrophobic 5
silica
Hydrophilic 5
silica
Tea tree oil 3
Sea buckthorn 5
oil
Vitamin A 0.1
Vitamin C 1.7
Vitamin E acetate0.1
Methylparaben 0.1
Purified water60
The water may ly contain 25 -
optional 400 ppm of Ag.
Example 9
This example
deals with a
composition
applicable for
preventing abnormal
hair loss and
for treating
alopecia:
Formulation in
wt%
Dead Sea salt 1.5
Hydrophilic silica4
Hydrophobic silica6
Propylene glycol30
Methylparaben 0.1
Sea buckthorn 2
oil
Minoxidil 7.4
Purified water 50
The water may optionally contain 25 - 400 ppm of Ag.
This is a highly effective composition. In addition to its function in
removing undesired
fatty materials from the treated area it plays an important role in
facilitating the penetration of
minoxidil (an anti-balding drug that is applied directly to the scalp) inside
the hair follicles.
Example 10.
This example deals with a highly effective composition for treating eczema and
atopic
dermatitis:
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CA 02534306 2006-O1-30
Formulation in wt%
Hydrophilic 7.5
silica
Hydrophobic 2.5
silica
Dead Sea salt 12
Zinc acetate 5
Methylparaben 0.1
Retinyl palmilate
(Vitamin A) 0.1
Aloe vera 0.1
Vitamin E acetate0.1
Primrose oil 3
Sea buckthorn 3
oil
Borage oil 3.6
Purified water 63
The water may contain 25 - 400
optionally ppm of Ag.
Example 12
A composition for treating acne
Formulation in wt%
Hydrophilic silica 7.5
Hydrophobic silica 2.5
Dead Sea salt 20
Propylene glycol 3.0
Retinyl palmilate 0.10
Methyl paraben 0.20
Propylparaben 0.10
Aloe barbadensis (Aloe vera) leaf powder 0.10
Tocopheryl acetate (Vitamin E) 0.10
Salicylic acid 0.5 to 2.0
Purified water 64.4 to 65.9 (depending on the amount of salicylic acid)
Note: Similar formulations for treating acne containing higher concentrations
of salicylic acid
(such as, for example, 3 to l2wt%) are within the scope of present invention,
as well.
CA 02534306 2006-O1-30
Examute 13
A composition in the form of cream for treating cellulitis
Formulation in wt%
Hydrophilic silica7.5
Hydrophobic silica2.5
Dead Sea salt 18.7
Propylene glycol 2.8
Retinyl palmilate0.09
Methyl paraben 0.18
Propylparaben 0.09
Aloe barbadensis
(Aloe vera) leaf
powder 0.09
Tocopheryl acetate
(Vitamin E) 0.09
Imadazoidinyl 0.18
urea
Kojic acid 0.5
Limon oil 1.0
Wheat germ oil 1.0
Joroba oil 1.0
Peach oil 0.5
Calendula oil 0.5
Eucalypt oil 0.5
Sea buckthorn 0.5
White clay 1.0
Purified water 61.28
26
