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| (12) Patent Application: | (11) CA 2534317 |
|---|---|
| (54) English Title: | BENZIMIDAZOLE ACETONITRILES |
| (54) French Title: | BENZOXAZOLE ACETONITRILES |
| Status: | Deemed Abandoned and Beyond the Period of Reinstatement - Pending Response to Notice of Disregarded Communication |
| (51) International Patent Classification (IPC): |
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|---|---|
| (72) Inventors : |
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| (73) Owners : |
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| (71) Applicants : |
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| (74) Agent: | KIRBY EADES GALE BAKER |
| (74) Associate agent: | |
| (45) Issued: | |
| (86) PCT Filing Date: | 2004-09-10 |
| (87) Open to Public Inspection: | 2005-03-24 |
| Examination requested: | 2009-07-14 |
| Availability of licence: | N/A |
| Dedicated to the Public: | N/A |
| (25) Language of filing: | English |
| Patent Cooperation Treaty (PCT): | Yes |
|---|---|
| (86) PCT Filing Number: | PCT/EP2004/052137 |
| (87) International Publication Number: | EP2004052137 |
| (85) National Entry: | 2006-01-31 |
| (30) Application Priority Data: | ||||||
|---|---|---|---|---|---|---|
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The present invention is related to benzimidazole acetonitriles as well as to
pharmaceutical formulations containing such benzimidazole acetonitriles of
formula (I). Said benzimidazole acetonitriles are useful in the treatment of
metabolic disorders mediated by insulin resistance or hyperglycemia,
comprising diabetes type II, inadequate glucosetolerance, insulin resistance,
obesity, polycystic ovary syndrome (PCOS) (I). The present invention is
furthermore related to methods of preparing ben7.oxazole acetonitriles. G is
pyrimidinyl; L is an amino group, or a 3-8 membered heterocycloalkyl,
containing at least one heteroatorn selected from N, O, S or L is an acylamino
moiety; R1 is selected from the group comprising or consisting of hydrogen,
sulfonyl, amino, carboxy, aminocarbonyl, CI-C6-alkyl, C2-C6-alkenyl, C2-C6-
alkynyl or Cl-C6-alkoxy, aryl,halogen, cyano or hydroxy;R2 is selected from
the group comprising or consisting of hydrogen, CI -C6-alkyl, C2-C6alkenyl, C2-
C6-alkynyl, or CI -C6-alkoxy.
L'invention concerne des benzoxazole acétonitriles ainsi que des formulations pharmaceutiques contenant ces benzoxazole acétonitriles représentés par la formule (I). Ces benzoxazole acétonitriles sont utiles dans le traitement de troubles métaboliques médiés par l'insulino-résistance ou l'hyperglycémie, notamment le diabète du type II, une tolérance au glucose inadéquate, l'insulino-résistance, l'obésité, le syndrome des ovaires polykystiques (PCOS) (I). L'invention concerne également des méthodes permettant de préparer des benzoxazole acétonitriles. G représente pyrimidinyle ; L représente un groupe amino ou un hétérocycloalkyle à 3-8 éléments contenant au moins un hétéroatome choisi dans le groupe constitué de N, O, S ou L représente une fraction acylamino. R?1¿ est choisi dans le groupe comprenant ou constitué de : hydrogène, sulfonyle, amino, carboxy, aminocarbonyle, alkyle C1-C6, alcényle C¿2?-C¿6?, alkynyle C¿2?-C¿6? ou alcoxy C¿1?-C¿6?, aryle, halogène, cyano ou hydroxy. R?2¿ est choisi dans le groupe comprenant ou constitué de : hydrogène, alkyle C1-C6, alcényle C¿2?-C¿6?, alkynyle C¿2?-C¿6? ou alcoxy C¿1?-C¿6?.
Note: Claims are shown in the official language in which they were submitted.
Sorry, the claims for patent document number 2534317 were not found.
Text is not available for all patent documents. The current dates of coverage are on the
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page
Note: Descriptions are shown in the official language in which they were submitted.
Sorry, the description for patent document number 2534317 was not found. Text is not available for all patent documents. The current dates of coverage are on the Currency of Information page
2024-08-01:As part of the Next Generation Patents (NGP) transition, the Canadian Patents Database (CPD) now contains a more detailed Event History, which replicates the Event Log of our new back-office solution.
Please note that "Inactive:" events refers to events no longer in use in our new back-office solution.
For a clearer understanding of the status of the application/patent presented on this page, the site Disclaimer , as well as the definitions for Patent , Event History , Maintenance Fee and Payment History should be consulted.
| Description | Date |
|---|---|
| Application Not Reinstated by Deadline | 2011-09-12 |
| Time Limit for Reversal Expired | 2011-09-12 |
| Deemed Abandoned - Failure to Respond to Maintenance Fee Notice | 2010-09-10 |
| Letter Sent | 2010-01-20 |
| Letter Sent | 2010-01-11 |
| Letter Sent | 2010-01-05 |
| Letter Sent | 2010-01-05 |
| Letter Sent | 2009-08-31 |
| Request for Examination Received | 2009-07-14 |
| All Requirements for Examination Determined Compliant | 2009-07-14 |
| Request for Examination Requirements Determined Compliant | 2009-07-14 |
| Letter Sent | 2008-11-27 |
| Correct Applicant Request Received | 2006-11-14 |
| Letter Sent | 2006-09-27 |
| Inactive: Single transfer | 2006-08-17 |
| Inactive: Courtesy letter - Evidence | 2006-04-04 |
| Inactive: Cover page published | 2006-04-03 |
| Inactive: Notice - National entry - No RFE | 2006-03-29 |
| Application Received - PCT | 2006-02-23 |
| National Entry Requirements Determined Compliant | 2006-01-31 |
| Application Published (Open to Public Inspection) | 2005-03-24 |
| Abandonment Date | Reason | Reinstatement Date |
|---|---|---|
| 2010-09-10 |
The last payment was received on 2009-08-12
Note : If the full payment has not been received on or before the date indicated, a further fee may be required which may be one of the following
Patent fees are adjusted on the 1st of January every year. The amounts above are the current amounts if received by December 31 of the current year.
Please refer to the CIPO
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web page to see all current fee amounts.
| Fee Type | Anniversary Year | Due Date | Paid Date |
|---|---|---|---|
| Basic national fee - standard | 2006-01-31 | ||
| Registration of a document | 2006-01-31 | ||
| MF (application, 2nd anniv.) - standard | 02 | 2006-09-11 | 2006-08-10 |
| MF (application, 3rd anniv.) - standard | 03 | 2007-09-10 | 2007-08-14 |
| MF (application, 4th anniv.) - standard | 04 | 2008-09-10 | 2008-08-14 |
| Registration of a document | 2008-08-18 | ||
| Request for examination - standard | 2009-07-14 | ||
| MF (application, 5th anniv.) - standard | 05 | 2009-09-10 | 2009-08-12 |
| Registration of a document | 2009-10-21 |
Note: Records showing the ownership history in alphabetical order.
| Current Owners on Record |
|---|
| MERCK SERONO SA |
| Past Owners on Record |
|---|
| JEAN-PIERRE GOTTELAND |
| MATTHIAS SCHWARZ |
| PASCALE GAILLARD |
| PATRICK PAGE |
| RUSSELL J. THOMAS |
