Note: Descriptions are shown in the official language in which they were submitted.
WO 2021/149827 1
PCT/JP2021/002352
te
: 7/7-1:/.'gq=HEHA-1.1
rkiird-31`f
[0001] 70AU, 7/74 <
7/74
k-Ziltt:{ 4143MV8Igt:15-tht.0=1-11]Alit:_111-0-Z.
14.*1-011i-
[0002] : Lx.)
Ke 5/7-r ,PAtiMIJI/F1,11-N -,:Lt\6,
(,:_fM/70,,tV84#7-LLC
c-c tc. Xs 1.) /slAw,njimj-0)
L --C JER tvc
3ff*--ettMVItRihgt:
1*-51SJSAgz_19),ILIVIIrVqL
[0003] /7-f Ute5 ¨3a1SaMOlgt/I(.7...
11;31-Z t op a), 2_1<tt12675LI-Z*;< VAU(z.ttULA,E'As!tIts.075\,
< Lo tc.iltRl,--C" o
[0004] 7/7-( '>:/M-JERPJL ---ClER tts '1411X --"S
VXM
t:-.3}ja 71Y105 1_, ct ta" s
f10)*' < 05741/A iztt
A, L7411 t\-5tt
7)1.
/tap, gt/X0DiaiRU,IAM
[0005] Nihr_ct
,fhAqd-R K. 75\--D, 7,1<04(,:_ct
31g-L's tt,g -to/tab, 7/
tatriih*A.gEli tc.MztalJel:A
tvrk,
5174:>-2(1)77)1.¨)1/4-gig-a
[0006]
¨ )1. -g--,ti=N )3MM801,00)*MC'ter4,-Ttt
5/7-f >JG)<t. -3 /".rin T 0 R KAM, I-AnkibliEztf122/141.1-gst,`,
A'r#:,.84#JERGAEREtz10.INCItterA7T7'_-t,-C-0 Z. 7 i=i
CA 03165081 2022- 7- 15
WO 2021/149827 2
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¨)1/-75-74ta tt:t 0
A.1-14-A=liUM
*Ecth-R
[0007] 14t,cg1 : WO 2 0 1 8/0 3 1 7 8 9 1-1?L6
14,g11x.2 :WO 20 1 8/1 2 93 6 4
HA =N
_______________________________ effiM ct
[0008] *RHAtg:_LEVNtrligiw).--Cts.t(I-Litt oye9,
yj\.
-Ds gZujiltetEliXt Th-Leti* 5/'V-1 z =1-
1E101J
STEVRATZ 1st) C/D fR
[0009] ftlE111-g6tt, 77)1,¨), 75"-D,
so
IMICtsa V:rfrtig0C(7),t4)
ftfL
tti-ZV7-4t141,7)-,-,4D-ftz-L-__Lt:_cl: 9 irigiagnAWATZ
71Y --e zr:
[0010] ttsb-64\RHAtt,
(a) 5/7--(.:>1%,
( b) I) )1,Ott=1,
>ct 9 44:Zg75\6infR-4-1,Z,-_>44: t fis )3z-Y
( c ) 1=1 E' 1, ¨)145zzf/ tc. ¨
MdEHM--C.bZe
[0011]
(a) 7/7--f:>%,
(b)
)1,034t= led ¨)k -;:,:fft::;=)1,Ez-rf
9 tsZU75µ65RIR-41.Z,-/-s< Lt 1 Ms
(c) 7 D EA,
Rve
(d) ihitt4EAU, 91-1E101J-ez.
CA 03165081 2022- 7- 15
WO 2021/149827 3 PCT/JP2021/002352
[0012]
(a)
( b ) 1)-1) )1,gtt= ¨)k t.R.r.f
771t
t 1 fa,
(c) V'm L71,
¨)145zzf/i-LttAim)=1,:J'i) .. Ezzf
( d 1) ti-i,RMAIJogAtigrAgasUS 5O
[0013]
( ) ( d 1) t-
TAR4LAUMElitt-IgtEg4M-4-zTTI', Eztf
) ) 6 41. tz_-374 G) (a) , (b) , )37õ--(f
(c)
(a) 5/7-,
( b ) )1,)yw 1,
1) 7-t
9 43:Uli\63,EIR-L'_ttt.'-fa:< Lt
(c) 7 1=1E1, ¨)1/R-OVA-Lttt:1) = L.> "i)
[0014] *ftlElAtt,
( ) tak4 LAU *LEIEvIt',Fetlgr,=-V-M 4-1.Z3E-Itt L,
) 1-:CF0 (a) ( b ) Rlf ) -
cf4 6
UZM-JERAIJ-C.bZo
(a) 5/7-1.>
( b ) ,)
-t.,:,031.:;=)1.)3z:rf F. ')Y
:Jct 9 t-s6g75\ 41,6 ts < t 1g
(c) 7PQ E'1,:Js'i) ¨A/73W/
RBA DOJA
[0015] *HC: 9 5 7V-Talia)M*1-Z
4?1-Z t l'z'P_Iii=4:-T-30-Z3}/%30#1/$1J-tt.tz_-_-ZitarALNWAIJ, !t
(LM-1ERPJI'Z'14=kt J. LlYicftgLts.Z
ffi l'cgrigl]il
[0016] [M1A] 0= 5. ¨)1/7..Q4a, i)
B H TME-E.,qa
CA 03165081 2022- 7- 15
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PCT/JP2021/002352
04 0 tc:..80.Z : 1=1 (R4T)
[1511B]:im .A.GD=
1) /3, B H TAE-E;V-A
05 OtrFI') (MI+) -7iN-4--M-e.bzo
[12127a.g. %¨ o%0B
LtEckZ, 4 0 Ctzzl,t5 0
M4>Y4)
MEIJI tc-_621)0JFIR,
[0017] 5/IL
*13A0M4RAlitt,
(a) 5/7-1>%,
( b) o) -tii)1,)3z:y l i)
:Jct 9 td:ZU75\ 6int)R--= tt.Z < t 1 fE, EzZf
( c ) 1. ¨ 'UV ¨ )1,,
[0018] (a) 5/,:/t,
ViRopt
075q1JJEllJ5O*IEIAM,*(z.80-c
5il=1')1,..P1
6.14-L
[0019] G,z, 7/7-(:',./0DEA414sL
[0020]
NALI-*-i4¶:11- GT, 0. 0 5- 1 MR% TZ
t7TL,<(J-Ø 1-0. 8%, litLtzTl,<M-Ø 1 ¨O. 5
[0021] gta ( b) )1.gk
Ez-Y ')1t. MeiVil
[0022] (c) LCS
3ISIt 7VIVR 7 m EL,
00) 031'-altePT < ,
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th3 LT{ Lt Az
[0023] ( b ) L'4114 (c) aD3'.g Eh
4-Lts. o 75i', IN A_ a
, Affitb---es (b) : (c) =2: 1-2 : 6jtL
L< tt (
b) : (c) =2 :
[0024]
(a) 5/74>Lg4-ta (c) Lo3gt-LthLlf---ctt, 7/v-17
(b) L'74t1 (c) 03% iSatz:-MWT FR 9 izs-s kiN -c
41, ts
75<, INAJX, *a.b--c., (a) : (c) =1 : 2 0 1 : 7
< tt, (a) : (c) =1 : 6 o -e 9 , ',4174 ( b ) t=g/stpt..-=*.bb
(a) : (b) : (c) =1 : 20-80 : 20-70, Pfl_.><a (a
) : (b) : (0) =1 : 25 : 6 o 75T1J7T-,'s tt.z.
[0025] 4cRIE11109=1-1,101Jtt, thikihOIJ ( d )
M-
1,11McLiK,RMMA)in-4-z LcLct 9, /'v
,'R1411,R4
k-Zitfrgig-4-z eiThigLtszo A1*ntslyi,K6MAIJLLC
Ki=1-1-)1.= (BHT) ,
(B H T) 75qtm-s-,1,z
[0026] ii-ilk-fbM(DMEHLCtts -11PJ,f4ctz-JJ-L-c, 1-1 o mg%iyipj,-Ttt
< tt 1 5%.. L<1 ¨ 2 %eltrSt--,Ls=rt,z,
[0027] ihikihAUtt, litiga (a) , (b) ,(c)
eiThtg-e 65Sth",k6ThAi_1LEITIt-gat:igAq ( d 1)
,E (a) (b) Rzf (c)
[0028] -) tsVA,Itt/lAL 7 4 7 -f
t
>031211-tt (17211,'fb&'1bil<A) ff*t.f tIT < l,,A1J15 7
4 :J7V#IET--:_t 4-1,z 0
0029] tnitibPJ(z\-1-0-za-Aft-taoplJER2tt, ______________ 2kb T
: MAElistg-M
= : 1 o ¨ 3 : 1 o fati L<tz3 : 1 o
[00u] Ihit,fhMRATItgtat:374flq tc3458-z ( d 1) 6(z,
eiMICT.bZõL 5iiJ u--c tt, H L B IY 4 ^'
CA 03165081 2022- 7- 15
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7 0-59-AttAdeiN7T--..
tITL < (,J: 5 ¨ 6 0 1 ivs_Lo-9T-M,ItAiJ75TIJ7T
ttz o
[0031] -t tdz-57-11tAli Liz 9 ,
6 izgz-Z4b
zo
[0032] u-rtt, fIJAAX,
5- 7 I) 03÷" ') ') R-07J ') 7J- ib
14: z
63EtR--,'_ttLzWd:<Lt, 1 fi, PT'gl,<tt,-<Lt,24,0t,075,16tt,
Z.
[0033] Al*ntsV-M5t,ItAIJ01PJL L-C
¨ POE :
') = 1 :4 (ffi'Mth
)
¨
7 ') Ot0",)-ti) : P 0 ER,ILLEH= 4 : 1 (AtL)
tt. 0
[0034] *RHAODAJERAIRt, it=RIEI)10)03W4btita:00,1EITER4):FOILTZtc.
alp vc..AAJER
151i tS.
--c
)1.4LAIJ, YAMAIJ. P HIPMALIõVskAirnMJ-CM
JER 1,-CtP100
[0035] 172)1i1LMLL
1.J.tg:L Fil
.:>)(
Km**>7 DL J1,-
- )3z.'ff D>fD L')1.)4 j3)1,:./)<
11/L ¨A, )t 3)'¨A, t
PAPJ
451.1 tS, Ki=i-*=:i7P1=1E)1.--t)1/Q
¨ 11a tt.Z. p H L-C tt, 1PJ
airaR, wk. >R,
=:J0t6, s 11/0k,
if,)1,0t6G)AtiltAPpAIJ
77)14J 1) .1L-raõ 7 7 11, )3 I) tAIL-ra,tTJJ
lizo IEREWORL ttitibt
itcfbtI ') iL
[0036]
CA 03165081 2022- 7- 15
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rd:1-th0)Et
1J-75(,1µ tt.z o
[0037] M-JERAlioNiELM
it\RHA0M-MANJ--, 1-:CF0at: TWAT z e-e zo
[0038]
(a) 7/74:>:/,
( b ) #1) )1,031= L. '9 ')
9 tszgT75\65NIRT4-tz/.:vts< t 1 a,
)
z
[0039] tc..th",0#4LMJER Ztai
( d 1) WEIEItigtat,7-74g3-4- RV'
( ) g J10) (a) , (b) , Ez-ef (c)
(a) 5/74,
( b ) -I)-') ,Ez-y
9 ta:ZET75` t 1 fis
(c) 7 1=1 ') ¨)1,/kt/V tc. tt I) = V' 1)
¨)1.,
tµga o
[0040] UT, ct V-/-1t0)-64091-1,101JV4z1-c_apt:_,
( ( d 2) t-tk6MALICdEpt-g-t74t,=-'411q G-c3MH-A11704
HLBe5-7 0) 1 iv,_L0)-57-M5tiltAi] A_ Ez
TY
( ) ( --(14 tt. tc374 -F
(a) 5/74:>%,
( b ) JI/nt.=
1) -t
9 tszET75\61afRsti.z/-/-s< t 1 fM,
(c) 1=1 ') ¨)I.Ezt/V ttt I) I)
vg.A 1-5/7-f -:-,o)V7.1<tt5t/E74-A] Lf15-4-ztaat,z)
9_wat,--ct,tk,\0
CA 03165081 2022- 7- 15
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[0041] _LE
0`)'1 ( d 2) tz=s-30---c, tj-i-,k6mOdRATItgtatz..-.MT
_L
E8 (i i)
,7'-1'>
007_1<ti-V-t/Z-74-A oDtVgit -1,46z
[0042] *RIEIA0M-JERlitt, *31_Ats#R4):F,S, ¨ AU, ¨
') )0X, WIX7J-0) 01, =
01-thORATlIgi-c.tthlIP_Itz..hr
, 7
F.5 flJ I TL.
t/l/Alk-f/)4/11.0¨,
5=s* '.)%,
E=J1/7
A1) 7 ')/1/b.t h ') As )4 h*:-/=1,>¨,<71,-r :Jot
') ') 1:1 fa: 0)
¨ ;
1=0, 7J-I)¨A, tt7J-A,
,)
,r7-t >ts eo -t =4A
; 4 ANJI 74
(//)14tA4L7KA)
; 7 1) ; ') 11,8k=T-11/, ') :/831= -
7J-:i5k
7 ;i)JLiJf
¨)Ii; K5'://1. L71=1 I) FJ ; FKX, ;
%.PJ ; ')
; 7J- I)
6k4L.1-tas 75,6iNattz
1 J-,k_L .3V-AWI-J-4- (71 õ
[0043] 91-111AdiDitfl
*R13/10)5/7-1':>%-git'idEllPitts ,ff-A'fAl$1.11/FlERA
IP] A_ tS1Z,SA10,058.0t:-JER0 zr: LIYUifC--e Z.
[0044] 1441WSEM4-0,0)1Pi
k L. ¨
Am=maµg, InTA, ;ns, '7- 1=1 K. il'AR,FaLiVrtt
iJNA, -3 --MiltiZM'As
mottRibaozaarc 1]8N
ffi,9))31,411EfA4751 tl.Z.
[0045] *RHAOM-l'HAliC'HOtc-MenOIR4Iffitt, _________________________ *tK,
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rA,h1-1::-,t 9 tt. es INA_ tX`I-JER JER ti
1-`1 tt,
717-f 01-1 00mg/m2
____________
A) _________________________ 9 IR4-1-Z e
[0046] 1-:CFV:-Ai*ntcr*-11) ,e.*ti-C*RHA 'TARA e,
t OD-C; < Z017 tcl-
7_RM)3z2)7..'77YR
'N-014,Wilil5ROMIRIt:jR,t-,'S tt.,4K1t1=910CIRItc.ttg_Rgii,
4-04 75qtflg tLZ.
[0047] ,.*=01_1 1
1 rj---71-*11-11,7_,
: g-we : 5 0 (mg
t) Ls V95 0t0)71<41=1=r-ChUND'.1_,--
CkEA5N9g41-
TrL'H4EtEML-C-7411q'ItfiggE OMM, ____ 1 LJZk
(PE )
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7 T:1 V ) "FM- (t-z- R)
:_1-1 e)
4 0 0)
1, 3 77 (:*
[0048] 1=1 I)
H P CgiUR"ffo, MOttNITITIOD:>Q1)14E'-
CA 03165081 2022- 7- 15
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[0049] WiTA-1 = _____________________________ 9i- PR Y6 .A Pit
(Ad Z.5)SM< . 2 7 8 n
t5b. : 6 mm,
25Omm izF15
t7L.2.1.:40tN3E.0¨ZE.I.
4th$F1 : 7 ')/1./0. 0 2 m o I /Lfilfgi'77":)=.z.,a-gi-
34I(p
H6. 0) = 1 3/7
= : O. 8 m L/3}
[0050] *-1-thiN 1 , .FL$3`tiN 1
1 tEgaef,a)-gtIL Ei Lc: ¨ )1, 1, 1:73.1'
= ') : : ¨.)1.7V 1 : 5 0 : 2 5
(ffiffi_bL) L td:
51.gir , *j5 0 t (07.1< 1=0 -Ch1:131% -rei-a3glEr,,4A4
Asg$4
tco tt.tc.I4M Ifl *NV LLOZ9 ER.
[0051] glqiltOMW 2 t,=,-T-4-e ')
Ez-Y, 77-t-vL Fi ¨ L 03'1' ACEH
= 9 , i=i ') Ogg efFNE:S
[.s2]
(A. 2)
ra" Ly=' __ ,Y ( P G) 60 13.A !) .1,
.7. Q.,)..j1104_-,
raA-
ffiTit
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PGiVf
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PG
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t;ii------- 3 :4 P G T:if(7 ( 2 V: ;MO
Lf1I------- 4 !) (--'=7 '11,7 47' -1V)
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[0052] A, 7' 1=1 E' 1, 0)N4-) Ai' 1) L.
¨A/CI]
CA 03165081 2022- 7- 15
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JER 4/MI -C t Ra05-75q41 tt.Z.
[0053] tfP.1 2 ---- 3 (ti-tAt4L1.10)Re.10)**g1")
2 % gl_hti -Cg1F4
tc3-1-2,5A(iCF % 1=1 ') ¨)1/AQ7-451I LT-15t) , a-Cf:>
¨ 11.7_1<g-541(Z, B H T 1 %LtSZck--)rj-EEIS',#tz_:34I
= ') B H T 8E -117-14a f-15
FAN L Fl B H T
fia EDTAJ-1.1) 71tztt M
)1411FR t r,
)in L tc37434111713,11 1) ¨
DI) /3.,B
H T ne,a7-4a0)-41.T.'41.1E-D 0-C, 4 0 C)37.7f 5 0 t --efX4 Lis 7 El4rETIAR
tf 3 0 11411,1"*ODMWE Z, _LE PittIC
i1=1 _L-xig)n#4< ,
[0054] Eztflai 1 A, BL7T-4-
0
:>I=1 ') tt,
= Lt ee-F Z Otc.,(,fli 2 )
1=1 ') B H gE g-Atz.= (t,
(;:.3vtt,
CAVE eigiA A. 6 tt:r it (4.%-fli 3 )
[0055] [3]
(õP 3 )
lAtitiLM 1CitstWiri
(A) ( A)-.-EHT *EDT A (A-BHT
A ,-BHT
;INo.6-2) (N0.3-
4-2)
0.2 g 020 g 0.20 g
0.20 A
õ 49.42 g 49.42 g 49.42
g 49.90 g_
BHT
0.10 g 0.10 g 0.10 g_
EDT A-Na g
=;_-L Ert ktma 0.10 g
g
50.38 g 50..26 g 50.18
g 50.00 g
100.0 g 100.0 g 100.0 g 100.2 g
CA 03165081 2022- 7- 15
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[-t4]
(P. 4)
B H T
40'C $fyr.
S7.3 38,4 80,6
2,7
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1).A.0)=37 J ¨ Ji474341t,¨_. fV7o3M,M.0) B H T
, 4 0 C Eztf 5 0 C 2 EirmR4 ito
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g 00 ='ff o
5
efiegE-.'S
[0057] [5]
(V. 5
BHT t2 te
11111111111111111111E3111111311111012111
96,73 90 357 9' 0,41
, =
9E Sk3,. 96,8 SE 42 90,1":
95-65 k-25
[0058] -A%41J 2 (filelti BHT on-E;)
1. 6%LtSZ,t tz_z4A,1171N 1,
7 D E ))i,D 1 . 6'Yo :Lz i tc.
ZEIM 1=1 I)
1.1 (Zs BHT .5' fyq
L54A (
CA 03165081 2022- 7- 15
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JF B H 5'4A Lf15-4- ) 014
[0059] Ei I) .L.'74ALBHT 7
: 3OU5L 1 10
00m i n-1 (DA-4-e-A311114*-'ff tco
ti.tc.A 3 134172IME
(----tZtE=/ff-Dko
TC*1-4-/*(,R,t=O- ti-iRtL321-4-1.-Cotc_
34-0Y, 2 $n Lk
[0060] -4r0IJ 3 JFI .6.74'ffIL B H /17-Siti.B5a7A
C tvr kiN a 17 6 t,7_771-11J-
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[0061] IfIV,M,00eW, ..59-;'tiltAij a Ez.-Y b JER tc_t4*XC3AtE
fa: < , 1E1 t, 3'1' =IX eV-Zt P.: WC tc o H L
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Jh C3AfEti11$1J1- tcobt:..tt, H B IFA 5
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a b
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CA 03165081 2022- 7- 15
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-FliaotA--ettix-OliNt4 Lis 50 t-e1S4 t_,-c 2 3FgrEMRZ4 MITEMZ=S-3
1) Litt
[0064] (- -rtim 4 )
if)1,4LP-14LzKAt:jcl 1_õ .391,0Alit.j.3"4 Z 0 .
2%J
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¨)I, iTilliS`--e3g tc.341)
iW
, B H vAtii 7 4
B H T 75%141-MtEZ-1 -C 1 . 5 % tSZ
(Zs WM5titPi(E12T- 1) >gg",.) )
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E. >51:11 O)31 H B = Vg 6 44: r:31.1)
3L1t_-_
)72)t,,tg,t7.1KA0D-A-AVYAll-MoAig 7 5 %Lts.Z,t r_171U LtcL
)1/1to)VOM ts tc.õ
[0065] (tht'dm 2)
if)1,4b)74LzKZ(.,=-1_õ ,i'74:39/41Alitr.3"41_,-C O. 2%Lta:Z,t
)31:1 tc. lill/iLAMZKAID-gE75%VAIJO)Pg 8 0% ta:
(Z..,171V
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CA 03165081 2022- 7- 15
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CA 03165081 2022- 7- 15
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