Note: Descriptions are shown in the official language in which they were submitted.
CA 03180863 2022-10-21
SOAP/AMINO ACID-TYPE FACIAL CLEANSING PRODUCT AND PREPARATION
METHOD THEREFOR
FIELD
[0001] The present disclosure relates to the field of cosmetics, and in
particular to a soap/amino
acid-type facial cleansing product and a preparation method thereof.
BACKGROUND
[0002] Facial cleansing products are cleansing products for facial skin, whose
purpose is to
remove dirt on the skin, make the skin refreshed, and help maintain the normal
physiological state
of the skin. Facial cleansing products can remove the skin physiological
metabolites such as
sebum, stratum corneum flakes and sweat, as well as dust, microorganisms,
residues of the
cosmetic used and the like, which are attached to the surface of the skin.
Among all skin care
products, the sale of facial cleansing products accounts for a relatively
large proportion.
[0003] According to the differences in the main ingredients used in facial
cleansing products on
the market, there are currently 7 systems: emulsifying facial cleansing
products, surfactant-type
facial cleansing products, soap-based type facial cleansing products, MAP
(monoalkyl
phosphate)-type facial cleansing products, SCI (sodium cocoyl isethionate)-
type facial cleansing
products, alkyl polyglucoside-type facial cleansing products, and amino acid-
type cleansing
products. Among them: 1) Emulsifying facial cleansing product: An
emulsification system is
adopted, and the appearance of the product is similar to that of ordinary
cream and lotion. Since it
does not contain or contains a small amount of surfactant, it is basically
free of foam when used,
and has poor cleaning effect. However, due to the use of an emulsification
system, it contains a
lot of oil, so it has a certain cleansing and emollient effect on skin, for
which the skin is smooth
after cleaned with it. It has a moisturizing feeling and excellent skin care
function, which is
suitable for neutral skin. 2) Surfactant-type facial cleansing product: With
ordinary surfactant as
the main component, it can be made into transparent or pearlescent system, of
which the
appearance is in the form of a flowable milky liquid or paste, the cleaning
effect is moderate, and
the foam richness is average. However, it may give consumers a feeling of
uncleanness, which is
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due to the inherent characteristic of surfactants. In addition, such products
are also prone to jelly
phenomenon at low temperature, which affects the effect of use by consumers.
Such products are
suitable for use on various types of skin, and have a low cost. For example,
the facial cleansing
lotion with disodium sulfosuccinate as the main surfactant on the market
belongs to the
surfactant-type product. 3) Soap-based type facial cleansing product: Fatty
acid soap is used as
the main component of this product, and the product has a thick paste-like
appearance, generally
has a strong pearlescent effect, rich foam and high cleaning efficiency. It is
suitable for oily skin,
while the disadvantage of it is that it will make skins feel tight or dry
after use. If consumers are
used to such type of product, they will depend on its cleaning efficiency, and
when they use other
types of facial cleansing products, they will feel that the cleaning
efficiency of other facial
cleansing products is not enough. 4) MAP-type facial cleansing product: MAP-
type facial
cleansing product has exactly the same appearance with regular shampoo, and
its use effect is
between the surfactant-type facial cleansing product and the soap-based type
facial cleansing
product. The foam thereof is richer than that of the surfactant-type facial
cleansing product but
less that of the soap-based type facial cleansing product, and the cleaning
efficiency thereof is
stronger than that of the surfactant-type facial cleansing product but not
stronger than that of the
soap-based type facial cleansing product. Therefore, this type of product is
suitable for various
types of skin. Mildness of the facial cleansing products with MAP as the main
surfactant is
between the general surfactant-type facial cleansing products and the soap-
based type facial
cleansing products. It is easy to be cleaned off, and has weak degreasing
efficiency, good use
performance and good skin feeling. However, the MAP-type product has low
viscosity and
insufficient product stability, which is easy to form a shear-thickening
system and appear
jelly-like appearance after thickened. 5) SCI-type facial cleansing product:
SCI-type facial
cleansing product mildly cleanses the skin with fine and rich foam, which has
unique soap-like
appearance and medium cost. The foam thereof is rich and fine, which can
penetrate into the skin
to clean skin. It feels very smooth when used in washing and rinsing, which
brings a more
comfortable feeling of use. 6) Alkyl polyglucoside-type facial cleansing
product: Alkyl
polyglucoside (APG) is a biomass surfactant prepared from the reaction of
natural renewable raw
materials glucose and fatty alcohols without generation of any toxic and
harmful by-products,
which is a non-ionic surfactant with comprehensive and excellent performance,
and also has the
characteristics of anionic surfactant. Alkyl polyglucoside surfactant is used
as the main ingredient
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of facial cleansing product, the use effect of this facial cleansing product
is similar to that of
ordinary surfactant-type facial cleansing product, but it has milder
characteristic and more
comfortable skin feeling, and it is safe and non-irritating, which is often
used as a transparent
product for infants and targets allergic skin. However, this type of product
is difficult to be
thickened, the foam thereof is not rich, and the appearance of the product is
not very beautiful,
which is generally similar to the appearance of shower gel. 7) Amino acid-type
cleansing
products: Amino acid-type cleansing product is the mildest product, which has
characteristics of a
comfortable skin feeling during use, and a strong moisturizing feeling after
use. There are two
types of such products in terms of state. One is paste-like without viscosity
and stringiness, which
is of pure amino acid system and is thickened by the properties of amino acid
itself, but the cost
thereof is very high. The other one is similar to the state of viscous
shampoo, which is generally
thickened by using thickening agents, and it generally cannot be made into
pure amino acid
system, and must be compounded with other surfactants, so the use effect
thereof is slightly poor
while the cost thereof is low.
[0004] Although there are many kinds of facial cleansing products on the
market, consumers
have higher and higher requirements for the feeling of use of facial cleansing
products, and the
demand for facial cleansing products with low irritation, high cleaning
efficiency, rich foam and
good feeling of use is also increasing. Therefore, it is very necessary to
develop a facial cleansing
product that can meet consumers' needs for mildness and cleansing efficiency
of the product.
SUMMARY
[0005] In view of this, it is necessary to provide a soap/amino acid-type
facial cleansing
product, which can meet consumers' requirements for cleansing products with
low irritation, high
cleaning efficiency, rich foam, and good feeling of use.
[0006] A soap/amino acid-type facial cleansing product, comprising an amino
acid surfactant, a
soap-based surfactant, an auxiliary surfactant, an auxiliary agent and a
solvent;
[0007] wherein, the amino acid surfactant is at least one selected from the
group consisting of
potassium cocoyl glycinate, sodium cocoyl glycinate, sodium lauroyl
sarcosinate, TEA-cocoyl
alaninate, sodium cocoyl glutamate, TEA-lauroyl glutamate, sodium lauroyl
glutamate and
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sodium palmitoyl glutamate;
[0008] the soap-based surfactant is at least one selected from the group
consisting of potassium
cocoate, potassium laurate, potassium myristate, potassium palmitate and
potassium stearate;
[0009] the auxiliary surfactant is at least one selected from the group
consisting of sodium
lauroamphoacetate, lauryl hydroxysulfobetaine, cocamidopropyl betaine, lauryl
glucoside, decyl
glucoside, cocamide, dodecyl dimethyl betaine and palm kernel oleamide.
[0010] In some embodiments, the amino acid surfactant is potassium cocoyl
glycinate and/or
sodium cocoyl glycinate; the auxiliary surfactant is at least two selected
from the group
consisting of sodium lauroamphoacetate, lauryl hydroxysulfobetaine,
cocamidopropyl betaine,
lauryl glucoside, decyl glucoside, cocamide, dodecyl dimethyl betaine and palm
kernel oleamide.
[0011] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: 0.1%-15% amino acid surfactant,
0.1%-15%
soap-based surfactant, 0.1%-20% auxiliary surfactant, 0.5%-20% auxiliary agent
and 30%-99%
solvent.
[0012] In some embodiments, the auxiliary agent includes a thickening agent, a
preservative,
and a pH adjusting agent.
[0013] In some embodiments, in the soap/amino acid-type facial cleansing
product, the weight
percentage of the thickening agent is within the range of 0.2% to 13%, the
weight percentage of
the preservative is within the range of 0.01% to 3%, and the weight percentage
of the pH
adjusting agent is within the range of 0.1% to 8%.
[0014] In some embodiments, the thickening agent is at least one selected from
the group
consisting of acrylate copolymers, sodium chloride, hydroxypropyl
methylcellulose, and acrylic
acid (acrylate)/stearyl alcohol polyethers-20 methacrylate cross linked
polymer.
[0015] In some embodiments, the preservative is at least one selected from the
group consisting
of hydantoin, quaternary ammonium salt-15, bisimidazolidinyl urea,
methylparaben, ethylparaben,
benzoic acid, sodium benzoate, sorbic acid and salicylic acid.
[0016] In some embodiments, the type of the soap/amino acid-type facial
cleansing product
includes facial cleansing milk, facial cleansing cream, facial cleansing
paste, facial cleansing
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lotion, facial cleansing gel, facial cleansing mousse or facial cleansing
soap.
[0017] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
0.1%-10%, potassium cocoate 0.5%-8%, sodium lauroamphoacetate 0.5%-8%, lauryl
hydroxysulfobetaine 0.1%-8%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium
chloride
0.01%-2%, hydroxypropyl methylcellulose 0.01%-3%, acrylic acid
(acrylate)/stearyl alcohol
polyethers-20 methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-
1%, pH adjusting
agent 0.1%4% and water 49%-98%.
[0018] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
1%-13%, potassium laurate 0.1%-9%, cocamidopropyl betaine 0.5%40%, lauryl
glucoside
0.1%-8%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-1%,
hydroxypropyl methylcellulose 0.01%-3%, acrylic acid (acrylate)/stearyl
alcohol polyethers-20
methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-1%, pH adjusting
agent 0.1%-1%
and water 44%-98%.
[0019] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
1%-15%, potassium myristate 0.5%40%, decyl glucoside 0.1%-7%, cocamide 1%-10%,
acrylic
acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-0.5%, hydroxypropyl
methylcellulose 0.1%-3%, acrylic acid (acrylate)/stearyl alcohol polyethers-20
methacrylate cross
linked polymer 0.1%-3%, preservative 0.01%-0.8%, pH adjusting agent 0.05%-3%
and water
43%-97%.
[0020] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
2%-12%, potassium stearate 1.5%-15%, dodecyl dimethyl betaine 1%-7%, palm
kernel oleamide
0.1%-5%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-1%,
hydroxypropyl methylcellulose 0.01%-2%, acrylic acid (acrylate)/stearyl
alcohol polyethers-20
methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-1%, pH adjusting
agent
0.05%4% and water 45%-95%.
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[0021] In some embodiments, the soap/amino acid-type facial cleansing product
further
comprises at least one of a skin conditioning agent and a functional
ingredient.
[0022] Another aspect of the present invention provides a method for preparing
a soap/amino
acid-type facial cleansing product, comprising the following step:
[0023] mixing together the raw materials of the above soap/amino acid-type
facial cleansing
product.
[0024] In some embodiments, the preparation method comprises the following
steps:
[0025] providing each raw material;
[0026] mixing the amino acid surfactant, the soap-based surfactant, and the
auxiliary surfactant
evenly, then adding the thickening agent, the pH adjusting agent, the
preservative and the
remaining other raw materials to the resulting mixture, and mixing evenly.
[0027] The technical solution of the present invention has the following
advantages:
[0028] In the soap/amino acid-type facial cleansing product of the present
invention, a specific
amino acid surfactant compounded with a specific soap-based surfactant is used
as the main body,
which is supplemented with a mild auxiliary surfactant, so as to make the
facial cleansing product
have good foaming properties, mildness and low irritation, greatly reducing
the irritation caused
by soap-based surfactants while ensuring the cleaning efficiency of the
product. This is because
the soap-based surfactants form soap precipitation with calcium and magnesium
ions in hard
water during use, which remains on the skin, giving poor feeling of use and
irritation. When the
soap-based surfactant is compounded with amino acid surfactant, the amino acid
surfactant will
remove the soap precipitation remained on the skin during use, improving the
feeling of use and
reducing irritation. In addition, the soap-based surfactant and amino acid
surfactant are both
anionic surfactants, and the auxiliary surfactants are mostly selected from
amphoteric surfactants,
i.e., a type of surfactant that has both cationic hydrophilic groups and
anionic hydrophilic groups.
When the amphoteric surfactant is used alone, its abilities of cleaning,
foaming and emulsifier
wetting are insufficient, but when compounded with soap-based surfactant and
amino acid
surfactant, it will have a synergistic effect on foaming, cleaning efficiency,
feeling of use, and
reducing irritation. .
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[0029] Before use, when this facial cleansing product is rubbed by hands, it
is easier to foam
and have richer foam than the amino acid-type facial cleansing. During use,
when this facial
cleansing product is rubbed on face, it feels milder than the soap-based type
facial cleansing, and
during the washing process, it is easier to be washed than the amino acid-type
facial cleansing.
After use, it presents stronger cleaning efficiency, fresher skin feeling, and
better oil control effect
than amino acid-type facial cleansing, and it gives less feelings of
tightness, dryness, and
irritation than soap-based facial cleansing, which meets the long-term demands
of consumers for
facial cleansing products with high cleaning efficiency, low irritation, and
no feeling of tightness
after use.
[0030] Moreover, this product has simpler formula than traditional facial
cleansing products,
low cost of the formula materials, and good product stability.
BRIEF DESCRIPTION OF DRAWINGS
[0031] FIG. 1 is the comparison diagram of the foaming efficiency of the
facial cleansing
.. products of Example 1 and Comparative Examples 1-2 of the present
invention;
[0032] FIG. 2 is the comparison diagram of the increase rates of skin water
loss using the facial
cleansing products of Example 1 and Comparative Examples 1-2 of the present
invention;
[0033] FIG. 3 is the comparison diagram of the change rates of skin oil
content using the facial
cleansing products of Example 1 and Comparative Examples 1-2 of the present
invention
[0034] FIG. 4 is the comparison diagram of the feeling of use of the facial
cleansing products
of Example 1 and Comparative Example 1 of the present invention;
[0035] FIG. 5 is the comparison diagram of the feeling of use of the facial
cleansing products
of Example 1 and Comparative Example 2 of the present invention.
DETAILED DESCRIPTION
[0036] In order to facilitate understanding of the present invention, the
present invention will
be described more thoroughly below, and preferred embodiments of the present
invention will be
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provided. However, the present invention may be achieved in many different
forms and is not
limited to the embodiments described herein. On the contrary, these
embodiments are provided to
help understand the present invention more thoroughly and completely.
[0037] Unless otherwise defined, all technical and scientific terms used
herein have the same
meaning as commonly understood by those of ordinary skill in the technical
field of the present
invention. The terms used herein in the specification of the present invention
are for the purpose
of describing specific embodiments only, and are not intended to limit the
present invention. As
used herein, the term "and/or" includes any and all combinations of one or
more of the associated
listed items.
[0038] An embodiment of the present invention provides a soap/amino acid-type
facial
cleansing product, comprising an amino acid surfactant, a soap-based
surfactant, an auxiliary
surfactant, an auxiliary agent and a solvent; wherein the amino acid
surfactant is at least one
selected from potassium cocoyl glycinate, sodium cocoyl glycinate, sodium
lauroyl sarcosinate,
TEA-cocoyl alaninate, sodium cocoyl glutamate, TEA-lauroyl glutamate, sodium
lauroyl
glutamate and sodium palmitoyl glutamate; the soap-based surfactant is at
least one selected from
potassium cocoate, potassium laurate, potassium myristate, potassium palmitate
and potassium
stearate; and the auxiliary surfactant is at least one selected from sodium
lauroamphoacetate,
lauryl hydroxysulfobetaine, cocamidopropyl betaine, lauryl glucoside, decyl
glucoside, cocamide,
dodecyl dimethyl betaine and palm kernel oleamide.
[0039] In the above-mentioned soap/amino acid-type facial cleansing product, a
specific amino
acid surfactant compounded with a specific soap-based surfactant is used as
the main body, which
is supplemented with a mild auxiliary surfactant, so as to make the facial
cleansing product have
good foaming properties, mildness and low irritation, greatly reducing the
irritation caused by
soap-based surfactants while ensuring the cleaning efficiency of the product.
Before use, when
this facial cleansing product is rubbed by hands, it is easier to foam and
have richer foam than the
amino acid-type facial cleansing. During use, when this facial cleansing
product is rubbed on face,
it feels milder than the soap-based type facial cleansing, and during the
washing process, it is
easier to be washed than the amino acid-type facial cleansing. After use, it
presents stronger
cleaning efficiency, fresher skin feeling, and better oil control effect than
amino acid-type facial
.. cleansing, and it gives less feelings of tightness, dryness, and irritation
than soap-based facial
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cleansing, which meets the long-term demands of consumers for facial cleansing
products with
high cleaning efficiency, low irritation, and no feeling of tightness after
use.
[0040] The characteristics of each component in the above-mentioned soap/amino
acid-type
facial cleansing product of the present invention are as follows:
[0041] 1) Amino acid surfactant: Amino acid surfactant is a mild and
degradable anionic
surfactant, which is an amino acid (such as glutamic acid, glycine) salt
(sodium salt, potassium
salt, triethanolamine salt) of coconut oil (or laurel oil or palm oil) with
foaming and
decontamination ability. The pH value of amino acid surfactant is 5.5-6.5,
which is close to that
of human skin, and amino acid is the basic substance that constitutes protein,
so it is mild and
non-irritating.
[0042] 2) Soap-based surfactant: Soap-based surfactant is an anionic
surfactant with low price,
its HLB (hydrophilic-lipophilic balance) shows highly hydrophilic, and it has
good cleaning and
degreasing efficiency.
[0043] 3) Auxiliary surfactant: It can enhance the detergency ability and
foaming stability of
the amino acid surfactant and soap-based surfactant, improving the cleaning
and conditioning
abilities of the product. For example, betaine amphoteric surfactants can be
compounded with
anionic amino acid surfactants and soap-based surfactants to improve safety
and increase
viscosity. Among them, dodecyl dimethyl betaine (BS-12) is soluble in water at
any pH with good
detergency ability, good foaming ability and good permeability, it is
resistant to hard water, and
has good biodegradability, low irritation, and mild performance, and it is
compatible well with
anions, cations and nonionic surfactants, and also has conditioning,
antistatic, softening and
sterilizing functions.
[0044] According to the category of hydrophilic groups, amino acid surfactants
can be divided
into glycine surfactants, sarcosine surfactants, alanine surfactants, and
glutamic acid surfactants.
The inventors conducted research and analysis on the performance of various
amino acid
surfactants and found that: in terms of refreshing feeling, glycine
surfactants > sarcosine
surfactants > alanine surfactants > glutamic acid surfactants; in terms of pH
value, glycine
surfactants>sarcosine surfactants>alanine surfactants>glutamic acid
surfactants. Therefore, when
compounded with soap-based surfactants, the preferred sequence of amino acid
surfactants for
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selection is glycine surfactants > sarcosine surfactants > alanine surfactants
> glutamic acid
surfactants. Meanwhile, although fatty acid salt as surfactant is soluble in
water, its solubility and
surface activity are easily affected by pH, metal ions such as calcium and
magnesium, and
temperature factors. It is easily hydrolyzed under acidic conditions so as to
lose surface activity
and decrease water solubility. Therefore, when selecting amino acids to be
compounded, glycine
surfactants and sarcosine surfactants whose pH is relatively close to alkaline
should be selected
first. However, the mildness and washing ability of sarcosine surfactants are
slightly inferior to
those of glycine surfactants, so glycine surfactants are more preferable.
[0045] In some embodiments, the amino acid surfactant is potassium cocoyl
glycinate and/or
.. sodium cocoyl glycinate; the auxiliary surfactant is at least two selected
from the group
consisting of sodium lauroamphoacetate, lauryl hydroxysulfobetaine,
cocamidopropyl betaine,
lauryl glucoside, decyl glucoside, cocamide, dodecyl dimethyl betaine and palm
kernel oleamide.
[0046] Further, the auxiliary surfactant is one selected from the group
consisting of a
combination of sodium lauroamphoacetate and lauryl hydroxysulfobetaine, a
combination of
.. cocamidopropyl betaine and lauryl glucoside, a combination of decyl
glucoside and cocamide,
and a combination of dodecyl dimethyl betaine and palm kernel oleamide.
[0047] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: 0.1%-15% amino acid surfactant,
0.1%-15%
soap-based surfactant, 0.1%-20% auxiliary surfactant, 0.5%-20% auxiliary agent
and 30%-99%
solvent.
[0048] In some embodiments, the auxiliary agent includes a thickening agent, a
preservative,
and a pH adjusting agent.
[0049] Further, in the soap/amino acid-type facial cleansing product, the
weight percentage of
the thickening agent is within the range of 0.2% to 13%, the weight percentage
of the
preservative is within the range of 0.01% to 3%, and the weight percentage of
the pH adjusting
agent is within the range of 0.1% to 8%.
[0050] It can be understood that a thickening agent, also known as gelling
agent, can increase
the viscosity or thickness of products to maintain a uniform and stable
suspension state or turbid
state, or to form gels; in addition, it also has an emulsifying effect. A
preservative can inhibit
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microbial activities, prevent product from spoilage, and make products have a
certain
preservation life. A pH adjusting agent, also known as acidity adjusting
agent, is used to maintain
or change the acidity or alkalinity of a product.
[0051] In some embodiments, the thickening agent is at least one selected from
the group
-- consisting of acrylate copolymers, sodium chloride, hydroxypropyl
methylcellulose, and acrylic
acid (acrylate)/stearyl alcohol polyethers-20 methacrylate cross linked
polymer.
[0052] In some embodiments, the thickening agent is a combination of acrylate
copolymers,
sodium chloride, hydroxypropyl methylcellulose, and acrylic acid
(acrylate)/stearyl alcohol
polyethers-20 methacrylate cross linked polymer. In this way, the combination
of the
-- above-mentioned various types of thickening agents can well improve the
viscosity of the facial
cleansing product of the present invention, while promoting the dispersibility
of each component
and maintaining the stability of the system.
[0053] In some embodiments, the preservative is at least one selected from the
group consisting
of hydantoin, quaternary ammonium salt-15, bisimidazolidinyl urea,
methylparaben, ethylparaben,
-- benzoic acid, sodium benzoate, sorbic acid and salicylic acid. Preferably,
the preservative is
hydantoin.
[0054] In some embodiments, the pH adjusting agent is an acid agent, an alkali
agent, and a salt
with a buffering effect to control the pH value required by the product. In
the present examples,
the pH adjusting agent is potassium hydroxide.
.. [0055] In some embodiments, the solvent is water.
[0056] In some embodiments, the type of soap/amino acid-type facial cleansing
product
includes facial cleansing milk, facial cleansing cream, facial cleansing
paste, facial cleansing
lotion, facial cleansing gel, facial cleansing mousse or facial cleansing
soap.
[0057] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
.. following components by weight percentage: potassium cocoyl
glycinate/sodium cocoyl glycinate
0.1%-10%, potassium cocoate 0.5%-8%, sodium lauroamphoacetate 0.5%-8%, lauryl
hydroxysulfobetaine 0.1%-8%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium
chloride
0.01%-2%, hydroxypropyl methylcellulose 0.01%-3%, acrylic acid
(acrylate)/stearyl alcohol
polyethers-20 methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-
1%, pH adjusting
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agent 0.1%-1% and water 49%-98%.
[0058] Further, the soap/amino acid-type cleansing product comprises the
following
components by weight percentage: potassium cocoyl glycinate/sodium cocoyl
glycinate 1%-10%,
potassium cocoate 2%-8%, sodium lauroamphoacetate 2%-8%, lauryl
hydroxysulfobetaine
1%-8%, acrylic acid (acrylate) copolymer 1%-5%, sodium chloride 0.1%-1%,
hydroxypropyl
methylcellulose 0.01%-0.5%, acrylic acid (acrylate)/stearyl alcohol polyethers-
20 methacrylate
cross linked polymer 1%-5%, preservative 0.1%-0.5%, pH adjusting agent 0.1%4%
and water
53%-90%.
[0059] In this soap/amino acid-type facial cleansing product, a specific soap-
based surfactant,
an amino acid surfactant and an auxiliary surfactant are cooperated according
to the
above-mentioned specific ratio, and also combined with a thickening agent and
the like. During
use, this product will foam rapidly, and the foam is large and rich.
[0060] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
1%-13%, potassium laurate 0.1%-9%, cocamidopropyl betaine 0.5%-10%, lauryl
glucoside
0.1%-8%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-1%,
hydroxypropyl methylcellulose 0.01%-3%, acrylic acid (acrylate)/stearyl
alcohol polyethers-20
methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-1%, pH adjusting
agent 0.1%-1%
and water 44%-98%.
[0061] Further, the soap/amino acid-type facial cleansing product comprises
the following
components by weight percentage: potassium cocoyl glycinate/sodium cocoyl
glycinate 5%-13%,
potassium laurate 0.1%-5%, cocamidopropyl betaine 2%-10%, lauryl glucoside 3%-
8%, acrylic
acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.1%-1%, hydroxypropyl
methylcellulose
0.1%-3%, acrylic acid (acrylate)/stearyl alcohol polyethers-20 methacrylate
cross linked polymer
1%-5%, preservative 0.1%-0.5%, pH adjusting agent 0.1%4% and water 48.5%-
88.5%.
[0062] In this soap/amino acid-type facial cleansing product, the added amount
of specific
amino acid surfactant and auxiliary surfactant is appropriately increased, and
the added amount of
specific soap-based surfactant is less than that of amino acid surfactant, so
that this facial
cleansing product has very low irritation, while having good foaming and
cleaning efficiency.
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Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
[0063] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
1%-15%, potassium myristate 0.5%40%, decyl glucoside 0.1%-7%, cocamide 1%-10%,
acrylic
acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-0.5%, hydroxypropyl
methylcellulose 0.1%-3%, acrylic acid (acrylate)/stearyl alcohol polyethers-20
methacrylate cross
linked polymer 0.1%-3%, preservative 0.01%-0.8%, pH adjusting agent 0.05%-3%
and water
43%-97%.
[0064] Further, the soap/amino acid-type facial cleansing product comprises
the following
components by weight percentage: potassium cocoyl glycinate/sodium cocoyl
glycinate 1%-5%,
potassium myristate 5%-10%, decyl glucoside 1%-5%, cocamide 1%-5%, acrylic
acid (acrylate)
copolymer 0.1%-5%, sodium chloride 0.01%-0.5%, hydroxypropyl methylcellulose
0.1%-3%,
acrylic acid (acrylate)/stearyl alcohol polyethers-20 methacrylate cross
linked polymer 0.5%-3%,
preservative 0.1%-0.5%, pH adjusting agent 0.1%-3% and water 59%-91%.
[0065] In this soap/amino acid-type facial cleansing product, the added amount
of specific
amino acid surfactant and auxiliary surfactant is less than that of soap-based
surfactant, so that
the product has good foaming ability, good cleaning efficiency, mildness and
low irritation.
[0066] In some embodiments, the soap/amino acid-type facial cleansing product
comprises the
following components by weight percentage: potassium cocoyl glycinate/sodium
cocoyl glycinate
2%-12%, potassium stearate 1.5%-15%, dodecyl dimethyl betaine 1%-7%, palm
kernel oleamide
0.1%-5%, acrylic acid (acrylate) copolymer 0.1%-5%, sodium chloride 0.01%-1%,
hydroxypropyl methylcellulose 0.01%-2%, acrylic acid (acrylate)/stearyl
alcohol polyethers-20
methacrylate cross linked polymer 0.1%-5%, preservative 0.01%-1%, pH adjusting
agent
0.05%4% and water 45%-95%.
[0067] Further, the soap/amino acid-type facial cleansing product comprises
the following
components by weight percentage: potassium cocoyl glycinate/sodium cocoyl
glycinate 2%-12%,
potassium stearate 2%-15%, dodecyl dimethyl betaine 1%-5%, palm kernel
oleamide 1%-5%,
acrylic acid (acrylate) copolymer 1%-5%, sodium chloride 0.1%-1%,
hydroxypropyl
methylcellulose 0.5%-2%, acrylic acid (acrylate)/stearyl alcohol polyethers-20
methacrylate cross
linked polymer 1%-5%, preservative 0.01%-1%, pH adjusting agent 0.05%-l% and
water
13
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
47%-91%.
[0068] In this soap/amino acid-type facial cleansing product, the components
are cooperated
according to the above ratio, and the product has good fluidity. During use,
it is easily dispersed
by water, and is easy to foam and be washed off.
[0069] In some embodiments, the soap/amino acid-type facial cleansing product
further
comprises at least one of skin conditioning agent and functional ingredient.
[0070] Acceptable skin conditioning agents and functional ingredients are
added to the facial
cleansing product to impart specific skin feeling, efficacy and claims to the
product.
[0071] An embodiment of the present invention also provides a method for
preparing a
soap/amino acid-type facial cleansing product, comprising mixing together the
raw materials of
the above soap/amino acid-type facial cleansing product.
[0072] Specifically, the method comprises the following steps S10-S50.
[0073] S10. Preparing each raw material component according to the formula: an
amino acid
surfactant, a soap-based surfactant, an auxiliary surfactant, a thickening
agent, a preservative, a
pH adjusting agent, a solvent and other components such as a skin conditioning
agent and a
functional ingredient.
[0074] S20. Mixing the thickening agent and solvent, homogenizing the mixture
at low speed
at 10Hz-15Hz for 2 minutes, then stifling and mixing the mixture evenly at
20Hz-40Hz to obtain
a first mixture.
[0075] S30. Adding the amino acid surfactant, soap-based surfactant, and
auxiliary surfactant to
the first mixture, stifling and dispersing the mixture evenly to obtain a
second mixture.
[0076] S40. Adding the pH adjusting agent, preservative, and the remaining raw
materials such
as the skin conditioning agent and functional ingredient to the second mixture
while stifling,
continuing to stir and mix the mixture evenly, and then homogenizing the
mixture at low speed at
10Hz-15Hz for 2 minutes.
[0077] S50. Filtering out the materials.
[0078] The formula of the above preparation method is concise, in which the
raw materials are
14
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
easily accessible, and the cost of the formula materials is low. The obtained
product has good
stability, in which an amino acid surfactant compounded with a soap-based
surfactant is used as
the main body, supplemented with an auxiliary surfactant. Before use, when
this facial cleansing
product is rubbed by hands, it is easier to foam and have richer foam than the
amino acid-type
facial cleansing. During use, when this facial cleansing product is rubbed on
face, it feels milder
than the soap-based type facial cleansing, and during the washing process, it
is easier to be
washed than the amino acid-type facial cleansing. After use, it presents
stronger cleaning
efficiency, fresher skin feeling, and better oil control effect than amino
acid-type facial cleansing,
and it gives less feelings of tightness, dryness, and irritation than soap-
based facial cleansing,
which meets the long-term demands of consumers for facial cleansing products
with high
cleaning efficiency, and low irritation.
[0079] The following are specific examples
[0080] I. Preparation of soap/amino acid-type facial cleansing
[0081] 1. The formula of the soap/amino acid-type facial cleansings of the
Examples and the
Comparative Examples of the present invention are shown in Table 1 below.
Date Recue/Date Received 2022-10-21
CD
SD
CT
7./
CD
K1 [0082] Table 1
c
CD
CD
SD
CD
7:] Exampl Exampl Exampl Example Exampl Exampl
Example Comparative Comparative
CD
0 e 1 e 2 e 3 4 e 5 e 6
7 Example 1 Example 2
CD
CD
CL
IV
0
1.) Potassium cocoyl
1.) 8 8 10 - - -
12 15 -
8 glycinate
K) Amino acid
surfactant
Sodium cocoyl
- - - 8 8
5 - - -
glycinate
P
,
.3
Potassium cocoate 7 6 5 5 - -
- - 15 .3
rõ
Potassium laurate - - - - 5 -
- - -
rõ
Soap-based
'
,
surfactant Potassium
,
rõ
- - - - -
10 - - - ,
myristate
Potassium stearate - - - - -
8 - -
Sodium
lauroamphoacetat 3 5 - - - - - 3 3
Auxiliary e
surfactant Lauryl
hydroxysulfobetai 3 - - - - - - 3 3
ne
16
o
a)
Cocamidopropyl
7:] - - - - 8 -
- - -
CD
K, betaine
c
CD
CD
CI)
CD
7.]
CD Lauryl glucoside - 7 - 3 5 -
- - -
0
CD
CD
a
NJ
Q
NJ
1.) Decyl glucoside 5 5
8, - _ _ _
_ _ _
K)
Cocamide 5 5
_ _ _ _
_ _ _
P
.
,
.
Dodecyl dimethyl
. 3
_ - 7 - - -
5 - -
betaine
,,,
N)
N)
,
,
.
,:,
,
Palm kernel _ _ _ 5 _ _
5 _ _
oleamide
Acrylic acid
(acrylate) 1.5 1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5
Thickening
agent copolymer
Sodium
0.3 0.3 0.3 0.3 0.3 0.3
0.3 0.3 0.3
chloride
17
F6- Hydroxypropyl
7:]
CD
methylcellul 0-3 0.3 0.3 0.3 0.3 0.3 0.3 0.3
0.3
CD
cp o se
7:]
CD
O Acrylic acid
cp
cp (acryl ate)/ste ar
1.) yl alcohol
1.)
polyethers-20 2 2 2 2 2 2
2 2 2
methacrylate
cross linked
polymer
Hydantoin 0.5 0.5 0.5 0.5 0.5 0.5
0.5 0.5 0.5
Potassium hydroxide 0.2 0.2 0.2 0.2 0.2 0.2
0.2 0.2 0.2
balanc
Water balance balance balance balance
balance balance balance balance
18
CA 03180863 2022-10-21
[0083] 2. The specific preparation process of the facial cleansing product is
as follows:
[0084] 1) The following raw materials were accurately weighed:
[0085] Phase A (thickening phase): water, a thickening agent (acrylic acid
(acrylate)
copolymers, sodium chloride, hydroxypropyl methylcellulose, and acrylic acid
(acrylate)/stearyl
alcohol polyethers-20 methacrylate cross linked polymer).
[0086] Phase B (surfactant phase): an amino acid surfactant, a soap-based
surfactant and/or an
auxiliary surfactant.
[0087] Phase C (pH adjusting phase): a pH adjusting agent (potassium
hydroxide);
[0088] Phase D (remaining phase): a preservative (DMDM hydantoin), a skin
conditioning
agent, a functional ingredient, etc.
[0089] 2) The phase B was added to the main pot, homogenized at low speed at
10 Hz - 15 Hz
for 2 min, and stirred and mixed evenly at 20 Hz - 40 Hz.
[0090] 3) Phase A was added slowly to the pot while stifling, and the mixture
was stirred and
dispersed evenly.
[0091] 4) Phase C and phase D were added slowly to the above mixture while
stirring, and the
obtained mixture was stirred and dispersed evenly.
[0092] 5) The materials were filtered out with filter cloth.
[0093] II. Performance evaluation
[0094] A comparison of the performance tests of the soap/amino acid-type
facial cleansing
prepared in Example 1 with the amino acid type facial cleanser of Comparative
Example 1 and
the soap-based type facial cleansing of Comparative Example 2 of the present
invention was
carried out.
[0095] 1. Evaluation of foaming performance
[0096] 1) Test principle
[0097] Determination of foaming efficiency was carried out according to the
national standard
GB/T13173.6-91 determination method. The sample was prepared into a test
solution of a certain
19
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
concentration with water of certain hardness. Under a certain temperature
condition, 200mL of
the test solution flew to the surface of 50mL of the same test solution at the
bottom of a graduated
cylinder from a height of 90cm, and the measured foam height represented the
foaming ability of
the sample.
[0098] 2) Test method
[0099] Test reagents: calcium chloride CaCl2; magnesium sulfate MgSO4.71120
[00100] Test steps:
[00101] Preparation of 150ppm hard water
[00102] 0.0999g calcium chloride and 0.148g magnesium sulfate were weighed and
dissolved
with distilled water in a 1000mL volumetric flask, then the obtained solution
was diluted to the
mark and shaken well.
[00103] Preparation of test solution
[00104] 2.5g of the sample was weighed and dissolved with 150ppm hard water,
the resulting
mixture was transferred to a 1000mL volumetric flask, diluted to the mark, and
shaken well. The
solution was then aged in a constant temperature water bath at 40+/-0.5 C, and
the total time
from the sample was dissolved with water was 30min.
[00105] Determination of foaming efficiency
[00106] When the test solution was being aged, the water pump was started to
stabilize the water
temperature at 40 0.5 C using the circulating water to pass through the jacket
of a graduated
measuring tube. The inner wall of the graduated measuring tube was pre-soaked
with butyric
acid-sulfuric acid solution overnight, and rinsed with distilled water until
acid-free. During the
test, the inner wall of the graduated measuring tube was first rinsed with
distilled water, and then
rinsed with the test solution. The rinsing should be complete, and there
should be no foam left on
the inner wall.
[00107] The test solution was injected from the bottom of the graduated
measuring tube to
above the 50 mL mark, then the stopcock of the graduated measuring tube was
closed, the
graduated measuring tube was left to stand still for 5 minutes, and then the
stopcock was adjusted
so that the solution level was just at the 50 mL mark. A pipette was filled
with 200mL of the test
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
solution by suction, which was then placed on the top of the graduated
measuring tube. The
stopcock of the pipette was then opened to make the solution flow down, when
the solution in the
pipette was run out, the stopwatch was immediately started, the initial foam
height (the average
height of the edge and vertex of the foam was taken) was read, and a second
reading was
recorded at the end of 5 minutes. The above test was repeated 2-3 times with
new test solutions,
and the tube wall must be washed with the test solution before each test.
[00108] The hardness of water, the concentration of the test solution and the
temperature for
measurement specified above can be changed according to the requirements of
the product
standard, but the changes need to be explained.
[00109] Result expression
[00110] The foaming efficiency of the sample is expressed as the number of mm
of the initial
foam height or the foam height after 5min, and the average value of at least 3
results with errors
within the allowable range was taken as the final result, wherein the errors
between multiple test
results shall not exceed 5mm.
[00111] The experimental test results are shown in Table 2 below:
[00112] Table 2
Sample Comparative Example 2 Comparative
Example 1
Soap-based type facial Amino acid-type
facial Example 1 Soap/amino
acid-type facial cleansing
cleansing cleansing
Initial foam Foam height Initial foam Foam height Initial foam Foam height
Number of height after 5min height after 5min
height after 5min
tests
1 152 145 148 148 150
151
2 155 143 145 144 152
153
3 153 146 146 142 154
153
Mean 153.3 144.7 146.3 144.7 152
152.3
[00113] The foam height at Omin was recorded as an evaluation indicator for
the foaming
efficiency of the tested sample, and the foam height at 5min after foaming was
recorded as an
evaluation indicator for the foam stability. The test data were processed to
obtain a diagram of
21
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CA 03180863 2022-10-21
foaming efficiency and foam stability of different types of facial cleansings
as shown in FIG. 1.
[00114] It can be seen from FIG. 1 that the foaming efficiency of the soap-
based type facial
cleansing was the strongest, followed by the soap/amino acid-type facial
cleansing. However, the
foam stability of the soap-based type facial cleansing was poor, and a large
number of foams
thereof burst within 5 minutes, while the soap/amino acid-type facial
cleansing has the best foam
stability, followed by the amino acid-type facial cleansing. To sum up, the
soap/amino acid-type
facial cleansing of the present invention has relatively strong foaming
efficiency and the best
foam stability, which is overall better than soap-based type facial cleansing
and amino acid-type
facial cleansing in terms of foaming.
[00115] 2. Irritation evaluation
[00116] 1) Test principle: FICK diffusion law: dm/dt=D.A.dp/dx. The amount of
water emitted
through the skin was directly measured through the water vapor pressure
gradient formed by the
water loss of the stratum corneum at different bright spots near the epidermis
(within about 1 cm)
measured by two sets of temperature and humidity sensors. The TEWL value is an
important
indicator of the quality of the skin barrier, and the lower the TEWL value of
the skin is, the better
the moisturizing effect is, and vice versa.
[00117] 2) Test method
[00118] Test environment: the test environment had a temperature of 22 1 C and
a humidity of
50 5%, which was real-time dynamically monitored;
[00119] Test volunteers: At least 30 valid volunteers who were aged between 16-
65 years old
(except pregnant or breastfeeding women) with no serious systemic diseases, no
immunodeficiency or autoimmune diseases, and no history of severe allergies to
cosmetics, and
who had not used hormone drugs and immunosuppressants in the past month, had
not
participated in other clinical trials, had used the test drugs as required and
had complete
information. All volunteers should fill out an informed consent form before
the test.
[00120] Test steps:
[00121] Pre-test preparation: No product (cosmetics or topical medicines)
should be used on the
test site 2-3 days before the test. Before the experiment, the subjects needed
to agree to clean the
22
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
inner sides of their two forearms and air dry their forearms naturally. After
cleaned, the inner
sides of the subjects' two forearms were marked with measurement area. Before
the formal test,
the subjects should sit still in a standard room for at least 30 minutes,
without drinking water,
expose their forearms, place their forearms in a test state, and keep relaxed.
[00122] Test process: In the experiment, a 3x3 cm2 test area was marked on the
inner side of the
left and right arms of the subjects. Multiple areas can be marked on the same
arm, and the areas
were separated by lcm. The experimental samples and control samples were
randomly
distributed on the left and right arms. Measurements of skin water loss in the
test areas were
performed using a probe Tewameter TM300, and the average value of three tests
was taken. Nos.
1-3 were the soap-based type facial cleansing samples of Comparative Example
2, Nos. 4-6 were
the amino acid-type facial cleansing samples of Comparative Example 1, and
Nos. 7-9 were the
soap/amino acid-type facial cleansing samples of Example 1. The DO initial
value (blank value)
of each test area was first measured, then the same amount of the experimental
sample and the
control sample were applied to the test area of the subjects, which was rubbed
for the same
number of circles, then the skin was washed and air dried to measure the water
loss in the three
areas respectively. This test was measured once a week for consecutive 28
days. The test on the
same volunteer was done by the same surveyor.
[00123] Test data: According to the experimental design, the skin water loss
in each time period
was measured respectively, and the increase in skin water loss at each time
point was calculated.
The greater the increase in skin water loss, the greater the damage of the
sample to the skin
barrier and the greater the irritation of the sample.
[00124] 3) Test results and analysis:
[00125] The calculation formula of the reduction rate of skin water loss is:
W%=(W2-Wi)/Wi*100%
[00126] Note: W is the reduction rate of skin water loss, %;
[00127] W2 is the skin water loss value after using the sample;
[00128] Wi is the skin water loss value before using the sample;
[00129] the experimental test results are shown in Table 3 below:
23
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
[00130] Table 3
Number of subject 1 2 3 4 5 6 7 8 9
0 day Initial value 18.6 20.2 24 26.6 27.7 25.4 23.3
25.7 29.2
D7 value 21.1 21.9 24.8 25.9 26.9 24.3
23.8 26.8 29.6
7 days Increase rate /% 13.44 8.42 3.33 -2.63 -2.89 -4.33
2.15 4.28 1.37
Mean value 8.40 -3.28 2.60
D14 value 22.3 21.7 25.1 26.4 27.8
26.4 24.2 27.2 30.2
14
Increase rate 19.89 7.43 4.58 -0.75 0.36 3.94 3.86
6.61 3.42
days
Mean value 10.63 1.18 4.63
D21 value 21.8 22.5 26.3 25.7 27.1 25.8 23.1 26.9 29.8
21
Increase rate 17.20 11.39 9.58 -3.38 -2.17 1.57 -
0.86 4.67 2.05
days
Mean value 12.72 -1.32 1.96
D28 value 21.8 23.6 26.8 26.8 28 26.5
24.7 26.7 30.5
28
Increase rate 17.20 16.83 11.67 0.75 1.08 4.33
6.01 3.89 4.45
days
Mean value 15.23 2.06 4.78
[00131] The test data in the table above were processed to obtain a diagram of
the increase rates
of skin water loss for different types of facial cleansings as shown in FIG.
2. As can be seen from
FIG. 2, long-term use of the soap-based type facial cleansings increased the
water loss of the skin,
and gradually damaged the skin barrier, so the soap-based type facial
cleansings are more
irritating to the skin. Long-term use of the amino acid-type facial cleansing
had less damage to
the skin barrier and lower irritation to the skin. Long-term use of the
soap/amino acid-type facial
cleansing had relatively less damage to the skin barrier, and the damage was
relatively stable,
which would not increase with the increase of the use time. Therefore, the
soap/amino acid-type
facial cleansing of the present invention is also relatively less irritating
to the skin, which is close
to the amino acid-type cleansing.
[00132] 3. Cleaning performance evaluation
24
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
[00133] 1) Test principle
[00134] In the present invention, the evaluation of the oil-absorbing paper
using effect was
performed using the skin oil tester Sebumeter SM815 of German CK. The oil
content test was
carried out using the commonly recognized SEBUMETER method. This method is
based on the
principle of photometer: after a 0.1mm thick special matte tape absorbs the
oil on human skin, it
will become a translucent tape, so that the amount of light transmission
thereof will change, and
the more oil it absorbs, the greater the amount of light transmission thereof
will be, in which way
the content of skin oil can be measured. The biggest advantage of this method
is that the test
probe is small and easy to use, and any position of the skin can be tested.
This is an indirect
measurement method of oil gland secretions, and the results thereof can be
used to differentiate
between different skin types, making it possible to accurately know the oil
changes caused by
internal and external causes.
[00135] 2) Test method
[00136] Test environment: the test environment had a temperature of 22 1 C and
a humidity of
50 5%, which was real-time dynamically monitored;
[00137] Test volunteers: At least 30 valid volunteers who were aged between 16-
65 years old
(except pregnant or breastfeeding women) with no serious systemic diseases, no
immunodeficiency or autoimmune diseases, and no history of severe allergies to
cosmetics, and
who had not used hormone drugs and immunosuppressants in the past month, had
not
participated in other clinical trials, had used the test drugs as required and
had complete
information. All volunteers should fill out an informed consent form before
the test
[00138] Test steps:
[00139] Pre-test preparation: No product (cosmetics or topical medicines)
should be used on the
test site 2-3 days before the test. Before the experiment, 3 areas of a size
of 3cmx3cm were
drawn on the subjects' forehead respectively to evaluate the oil content of
the skin. For each
control sample, the average value of three people was taken to calculate the
percentage of oil
content increment for relevant evaluation.
[00140] Test process: After the subjects sat in a room with a constant
temperature and humidity
for 30 minutes, the oil content in the areas marked on their foreheads was
measured as the initial
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
value. Then the same amount of the experimental sample and the control sample
were applied to
the test area of the subjects, which was rubbed for the same number of
circles, then the skin was
washed and air dried to measure the oil content in the three areas
respectively. This test was
measured once every 20 min for consecutive 100 min. The test on the same
volunteer was done
by the same surveyor.
[00141] 3) Test results and analysis
[00142] The calculation formula of the change rate of oil content is: W%=(W2-
Wi)/Wix100%
[00143] Note: W is the change rate of oil content, %;
[00144] W2 is the skin oil content at 0/20/40/60/80/100min after using the
sample;
[00145] Wi is the skin oil content at Omin after using the sample;
[00146] the experimental test results are shown in Table 4 below:
[00147] Table 4
Oil content
Comparative Example 2 Comparative Example 1
Example 1 Soap/amino acid-type
Time Soap-based type facial Amino acid-type facial
facial cleansing
min cleansing cleansing
Test value Mean value Test value Mean value Test value Mean
value
60.21 48.45 52.86
55.53 52.9 50.54
0 57.79 50.1 55.44
57.63 48.95 62.92
90.1 115.8 101.69
85.34 112.54 98.54
20 87.23 111.01 97.24
86.25 104.69 91.49
95.23 120.34 112.21
98.4 121 109.1
40 101.98 116.58 112.43
112.31 108.4 115.98
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Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
121.5 127.89 122.2
119 140 131.7
60 115.11 134.89
125.9
104.83 136.78 123.8
144.89 143.55 150.3
92 145.1 158.9 142.
80 145.67 156.19
148.25
147.02 166.12 151.53
182.8 205.99 157.28
166.9 189 163.33
100 172.88 188.81
163.67
168.94 171.44 170.4
[00148] The data in Table 4 were processed to obtain the incremental trend
data of oil content
shown in Table 5 and a diagram of oil content change trend as shown in FIG. 3.
[00149] Table 5
Oil content change rate %
Time min Soap-based type facial Amino acid-type facial Soap/amino acid-type
facial
cleansing cleansing cleansing
0 0 0 0
20 50.94 121.58 75.40
40 76.47 132.69 102.80
60 99.19 169.24 127.09
80 152.07 211.76 167.41
100 199.15 276.87 195.22
[00150] It can be seen from the above Tables 4-5 and FIG. 3 that the soap-
based type facial
cleansing had the best oil removal effect. With the growth of time, due to the
strong cleansing and
degreasing ability of the soap-based type facial cleansing, the skin would
secrete more oil in
order to achieve the balance of water and oil, so after 60 minutes, the oil
secretion of the skin
27
Date Recue/Date Received 2022-10-21
CA 03180863 2022-10-21
cleaned with the soap-based type facial cleansing would increase rapidly. The
amino acid-type
facial cleansing had the worst oil removal effect. The soap/amino acid-type
facial cleansing of the
present invention had a degreasing effect close to that of the soap-based type
facial cleansing, and
the skin area cleaned with the soap/amino acid-type facial cleansing of the
present invention did
not present rapid secretion of oil over time.
[00151] 4. Evaluation of the feeling of use
[00152] 1) Test principle
[00153] The cosmetic sensory evaluation method was used. Sensory evaluation is
a special type
of in vivo experiment, and the cosmetic sensory evaluation is an evaluation
method that verifies
subjectivity such as the skin feeling of cosmetics use. The sensory evaluation
mainly includes
visual evaluation, olfactory evaluation and tactile evaluation, which
respectively relies on visual,
olfactory and tactile senses to evaluate appearance, color, smell, skin
feeling and the like of the
cosmetic. The sensory evaluation methods can be divided into difference test,
scale test,
descriptive test, preference test and so on. The performances of different
types of cosmetics are
also different. For example, the performance evaluation of paste, cream and
lotion products
mainly includes spreadability, moisturizing ability, oily feeling, stickiness,
etc., while the
performance evaluation of skin cleansing products and shampoo products mainly
includes ease of
washing, feeling of tightness, etc. In the present invention, the sensory
evaluation method of
preference test was mainly used, and the evaluation dimensions were mainly 5
dimensions, such
as ease of cleaning, no feeling of tightness, no feeling of dryness,
smoothness and refreshing
feeling. A comparison of sensory tests of the soap/amino acid-type facial
cleansing of Example 1
with the soap-based type facial cleansing of Comparative Example 2 and the
amino acid-type
facial cleansing of Comparative Example 1 was conducted respectively.
[00154] 2) Test method
[00155] Test environment: the test environment had a temperature of 22 1 C and
a humidity of
50 5%, which was real-time dynamically monitored;
[00156] Test volunteers: Volunteers who were aged between 16-65 years old
(except pregnant or
breastfeeding women) with no serious systemic diseases, no immunodeficiency or
autoimmune
diseases, and no history of severe allergies to cosmetics, and who had not
used hormone drugs
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CA 03180863 2022-10-21
and immunosuppressants in the past month, had not participated in other
clinical trials, had used
the test drugs as required and had complete information. All volunteers should
fill out an
informed consent form before the test.
[00157] Test steps:
[00158] Pre-test preparation: The subjects should not use any product
(cosmetics or topical
medicines) 2-3 days before the test. Before the experiment, the samples to be
tested were divided
equally, one for each subject.
[00159] Test process: The subjects sat still in a room with a constant
temperature and humidity
for 30 minutes, and then used the experimental samples and control samples
according to their
daily using habits. After their skin was washed and air dried, they filled out
questionnaires for
different samples respectively.
[00160] 3) Test results and analysis
[00161] According to the sensory evaluation results of consumers, the feeling
of use of the
samples was analyzed and evaluated to obtain the tests data as shown in Table
6 below. A
comparison diagram of the feeling of use of the soap/amino acid-type facial
cleansing of
Example 1 of the present invention and the soap-based type facial cleansing of
Comparative
Example 2 is shown in FIG. 4, and a comparison diagram of the feeling of use
of the soap/amino
acid-type facial cleansing of Example 1 of the present invention and the amino
acid-type facial
cleansing of Comparative Example 1 is show in FIG. 5
[00162] Table 6
Sample
Dimension Example 1
Comparative Example 2 Comparative Example 1
Soap/amino acid-type facial Soap-based type facial Amino acid-
type facial
cleansing cleansing cleansing
Refreshing
93.89 94.32 92.99
feeling
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CA 03180863 2022-10-21
Ease of
94.23 95.1 81.5
cleaning
No feeling
94.99 69.74 88.34
of tightness
No feeling
91.21 71.62 92.19
of dryness
Smoothness 92.83 75.34 91.58
[00163] It can be seen from Table 6 and FIGs. 4 to 5 that the soap/amino acid-
type facial
cleansing in Example 1 of the present invention was not different from the
soap-based type facial
cleansing in terms of refreshing feeling and ease of cleaning, but it was
obviously better than the
soap-based type facial cleansing in terms of smoothness, no feeling of dryness
and no feeling of
tightness. Although the amino acid-type facial cleansing was superior to the
soap/amino acid-type
facial cleansing in terms of smoothness, the soap/amino acid-type facial
cleansing was superior to
the amino acid-type facial cleansing in terms of refreshing feeling, ease of
cleaning, no feeling of
tightness and no feeling of dryness. To sum up, the soap/amino acid-type
facial cleansing in
Example 1 of the present invention is generally better than the soap-based
type facial cleansing
and the amino acid-type facial cleansing in terms of feeling of use.
[00164] The inventors tested various properties of the soap/amino acid-type
facial cleansings of
Examples 2 to 7, and found that the facial cleansings in Examples 2 to 7 all
had good foaming
performance, low irritation, good cleaning efficiency and good feeling of use.
[00165] The technical features of the above-described examples can be combined
arbitrarily. In
order to make description brief, all possible combinations of the technical
features in the
above-described examples are not described. However, as long as there is no
contradiction
between the combinations of these technical features, all of them should be
regarded as the scope
described in this specification.
[00166] The above-mentioned examples only represent several embodiments of the
present
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CA 03180863 2022-10-21
invention, and the descriptions thereof are specific and detailed, but should
not be construed as a
limitation on the scope of the present invention. It should be noted that for
those of ordinary skill
in the art, several modifications and improvements can also be made without
departing from the
concept of the present invention, which all belong to the protection scope of
the present invention.
Therefore, the protection scope of the present invention should be subject to
the appended claims.
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