INTEGRIN RECEPTOR ANTAGONISTS

ANTAGONISTES RECEPTEURS D'INTEGRINE

English Abstract

The invention relates to new compounds which bind to integrin receptors, as
well as to their production, their use as integrin receptor antagonists and
for the treatment of diseases, pharmaceutical preparations containing said
compounds and pharmaceutical preparations containing at least one other active
compound.

French Abstract

L'invention concerne des composés se liant à des récepteurs d'intégrine, leur fabrication, leur utilisation comme antagonistes récepteurs d'intégrine et pour le traitement de maladies, des préparations pharmaceutiques renfermant ces composés, ainsi que des préparations pharmaceutiques renfermant au moins un autre composé actif.

Claims

-357-

We claim:

1. A compound of the formula I
A-E-G-L I
where A, E, G and L have the following meanings:
L a structural element of the formula I L,
Image
where
a is 0 or 1,
T is a COOH group or a radical which can be hydrolyzed to COOH,
R2 is hydrogen, NHSO2R21, NHCOR21 or NHCOOR22,
where
R21 is a branched or unbranched, optionally substituted C1-C6-alkyl, C3-C6-
cycloalkyl, C1-C4-alkyl-C3-C6-cycloalkyl radical, C5-C12-bicycloalkyl or
C6-C18-tricycloalkyl radical, an up to trisubstituted, with identical or
different radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6-
membered, saturated, unsaturated or aromatic heterocycle which may
contain up to three different or identical heteroatoms O, N, S, it being
possible for two radicals together to be a fused, saturated, unsaturated
or aromatic carbocycle or heterocycle which may contain up to three
different or identical heteroatoms O, N, S, and this ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated
or aromatic ring can be fused to this ring,



-358-

R22 is a branched or unbranched, optionally substituted C1-C6-alkyl radical
or an optionally substituted aryl or alkylaryl radical,
R3 is hydrogen or -(CH2)b-(X)c -R31,
where
b is 0, 1, 2 or 3,
c is 0 or 1,
X is -SO2-, -S-, -O-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-
,-CO-N(R31)-, -N(R31)-CO-, -SO2-NH-, -SO2-N(R31)- or -N(R31)-SO2-
R31 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary
substitution, an optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl
or C2-C6-alkenyl radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl
radical or a 3- to 6-membered, saturated or unsaturated heterocycle
which is substituted by up to three identical or different radicals and
which may contain up to three different or identical heteroatoms O, N,
S, C3-C8-cycloalkyl, aryl or hetaryl radical, it being possible for two
radicals together to be a fused, saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and the ring can optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
and~
R4 is hydrogen, or a branched or unbranched, optionally substituted C~-a-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
G a structural element of the formula I G,


-359-
Image
where
d is 0, 1 or 2,
R5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary
substitution, an optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl
or C2-C6-alkenyl radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl
radical or a 3- to 6-membered, saturated or unsaturated heterocycle
which is substituted by up to three identical or different radicals and
which may contain up to three different or identical heteroatoms O, N,
S, C3-8-cycloalkyl, aryl or hetaryl radical, it being possible for two
radicals together to be a saturated, unsaturated or aromatic carbocycle
or heterocycle which may contain up to three different or identical
heteroatoms O, N, S, and the ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring
can be fused to this ring, or the side chain of a natural amino acid,
R6 is hydrogen or a branched or unbranched, optionally substituted C1-4-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
E a structural element of the formula I E
-(NH)g-(CH2)f-Q-(CH2)e-CO- I E
where
a is 0, 1 or 2,
f is 0 or 1,


-360-
g is 0 or 1,
Q is a doubly linked, optionally substituted hetaryl radical, it being
possible
for two substituents together to be a saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and this ring can optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
A one of the structural elements of the formulae I A1 to I A20,
Image


-361-
where
R10, R11 are, independently of one another, hydrogen, -(CH2)h-(Y)i-R101, or
the two
radicals together are a 3- to 8-membered, optionally substituted, saturated,
unsaturated or aromatic N-heterocycle which may additionally contain two
other, identical or different heteroatoms O, N or S,
where
h is 0, 1, 2 or 3,
i is 0 or 1,
Y is -SO2-, -S-, -O-, -CO-, -NH-SO2-, -O-CO-, -CO-O-, -NH-CO-,
-CO-NH-, -CO-N(R101)-, -N(R101)-CO-, -SO2-NH-, -N(R101)-SO2- or
-SO2-N(R101)- and
R101 is a hydroxyl group, a branched or unbranched, optionally substituted
C1-C6-alkyl, C1-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an amino
radical with primary or optionally secondary or tertiary substitution, an
optionally C1-C4-alkyl- or aryl-substituted C2-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C12-bicycloalkyl, C6-C18-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted
by up to three identical or different radicals and which may contain up to
three different or identical heteroatoms O, N, S, C3-8-cycloalkyl, aryl or
hetaryl radical, it being possible for two radicals together to be a fused,
saturated, unsaturated or aromatic carbocycle or heterocycle which
may contain up to three different or identical heteroatoms O, N, S, and
the ring can optionally be substituted, or another, optionally substituted,
saturated, unsaturated or aromatic ring can be fused to this ring,
R12 is a branched or unbranched, optionally substituted C1-C4-alkyl,
alkylaryl,
C3-C6-cycloalkyl or C1-C4-alkyl-C3-C6-cycloalkyl radical or an optionally
substituted aryl radical,


-362-
R13 is hydrogen, -OH, -CN, -CONH2, a branched or unbranched, optionally
substituted C1-C4-alkyl, C1-C4-alkoxy or -O-CO-C1-C4-alkyl radical, or an
optionally substituted alkylaryl, -O-alkylaryl, -O-CO-aryl, -O-CO-alkylaryl or
-O-CO-allyl radical,
R14 is hydrogen, a branched or unbranched, optionally substituted C1-C4-alkyl,
-CO-O-C1-C4-alkyl, alkylaryl, -CO-O-alkylaryl, -CO-O-allyl, -CO-C,-C4-alkyl,
-CO-alkylaryl or -CO-allyl radical,
R15 is hydrogen, a branched or unbranched, optionally substituted C1-C4-alkyl
radical or an optionally substituted aryl or alkylaryl radical,
R16, R17 are, independently of one another, -NH2, halogen or a branched or
unbranched, optionally substituted C1-C4-alkyl or C1-C4-alkoxy radical or an
optionally substituted aryl radical,
Z1, Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or
N,
and the physiologically tolerated salts, prodrugs and the enantiomerically
pure or
diastereomerically pure and tautomeric forms.
2. A pharmaceutical preparation for oral or parenteral administration,
comprising at
least one compound as claimed in claim 1 besides conventional pharmaceutical
excipients.
3. The use of a compound as claimed in claim 1 for producing drugs for
treating
diseases.
4. The use as claimed in claim 3 of a compound as claimed in claim 1 as
integrin
receptor antagonist.
5. The use as claimed in claim 4 of a compound as claimed in claim 1 as
antagonist
of the .alpha.v.beta.3 integrin receptor.
6. The use of a compound as claimed in claim 1 for producing drugs for
treating
diseases in which an integrin receptor is involved.



-363-
7. The use as claimed in claim 6 of a compound as claimed in claim 1 for
treating
diseases in which the .alpha.v.beta.3 integrin receptor is involved.
8. The use as claimed in claim 7 of a compound as claimed in claim 1 for
treating
atherosclerosis, rheumatoid arthritis, restenosis after vessel injury,
angioplasty,
acute kidney failure, angiogenesis-associated microangiopathies, diabetic
angiopathies, blood platelet-mediated vascular occlusion, arterial thrombosis,
congestive heart failure, myocardial infarct, stroke, cancer, osteoporosis,
high
blood pressure, psoriasis or viral, parasitic or bacterial diseases,
inflammations,
wound healing, hyperparathyroidism, Paget's disease, malignant hypercalcemia
or
metastatic osteolytic lesions.
9. A pharmaceutical preparation comprising at least one compound as claimed in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
inhibitors of blood platelet adhesion, activation or aggregation,
anticoagulants which prevent thrombin activity or formation,
antagonists of blood platelet-activating compounds or
selectin antagonists.
10. The use of the pharmaceutical preparation as claimed in claim 9 for
producing a
drug for treating blood platelet-mediated vascular occlusion or thrombosis.
11. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
inhibitors of blood platelet activation or aggregation,
serine protease inhibitors,
fibrinogen-reducing compounds,
selectin antagonists,
antagonists of ICAM-1 or VCAM-1
inhibitors of leukocyte adhesion
inhibitors of vessel wall transmigration,
fibrinolysis-modulating compounds,
inhibitors of complement factors,
endothelin receptor antagonists,
tyrosine kinase inhibitors,


-364-
antioxidants or
interleukin 8 antagonists.
12. The use of the pharmaceutical preparation as claimed in claim 11 for
producing a
drug for treating myocardial infarct or stroke.
13. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
endothelia antagonists,
ACE inhibitors,
angiotensin receptor antagonists,
endopeptidase inhibitors,
beta blockers,
calcium channel blockers,
phosphodiesterase inhibitors or
caspase inhibitors.
14. The use of the pharmaceutical preparation as claimed in claim 13 for
producing a
drug for treating congestive heart failure.
15. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
thrombin inhibitors,
inhibitors of factor Xa,
inhibitors of the coagulation pathway which leads to thrombin formation,
inhibitors of blood platelet adhesion, activation or aggregation,
endothelia receptor antagonists,
nitric oxide synthase inhibitors,
CD44 antagonists,
selectin antagonists,
MCP-1 antagonists,
inhibitors of signal transduction in proliferating cells,
antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF, or
antioxidants.



-365-
16. The use of the pharmaceutical preparation as claimed in claim 15 for
producing a
drug for treating restenosis after vessel injury or stent implantation.
17. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
antagonists of the cellular response mediated by EGF, PDGF, VEGF or bFGF,
heparin or low molecular weight heparins or other GAGs,
inhibitors of MMPs,
selectin antagonists,
endothelia antagonists,
ACE inhibitors,
angiotensin receptor antagonists,
glycosylation inhibitors or
AGE formation inhibitors or antagonists of their receptors.
18. The use of the pharmaceutical preparation as claimed in claim 17 for
producing a
drug for treating diabetic angiopathies.
19. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
lipid-lowering compounds,
selectin antagonists,
antagonists of ICAM-1 or VCAM-1
heparin or low molecular weight heparin or other GAGs,
inhibitors of MMPs,
endothelia antagonists,
apolipoprotein A1 antagonists,
cholesterol antagonists,
HMG-CoA reductase inhibitors,
ACAT inhibitors,
ACE inhibitors,
angiotensin receptor antagonists,
tyrosine kinase inhibitors,


-366-
protein kinase C inhibitors,
calcium channel blockers,
LDL receptor function stimulants,
antioxidants or
free radical scavengers.
20. The use of the pharmaceutical preparation as claimed in claim 19 for
producing a
drug for treating atherosclerosis.
21. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
cytostatic or antineoplastic compounds,
compounds which inhibit proliferation or
heparin or low molecular weight heparins or other GAGs.
22. The use of the pharmaceutical preparation as claimed in claim 21 for
producing a
drug for treating cancer.
23. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the group of
compounds for antiresorptive therapy,
compounds for hormone replacement therapy,
recombinant human growth hormone,
bisphosphonates,
compounds for calcitonin therapy,
calcitonin stimulants,
calcium channel blockers,
bone formation stimulants,
interleukin-6 antagonists or
Src tyrosine kinase inhibitors.
24. The use of the pharmaceutical preparation as claimed in claim 23 for
producing a
drug for treating osteoporosis.


-367-
25. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, where appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
TNF antagonists,
antagonists of VLA-4 or VCAM-1,
antagonists of LFA-1, Mac-1 or ICAMs,
complement inhibitors,
immunosuppressants,
interleukin-1, -5 or -8 antagonists or
dihydrofolate reductase inhibitors.
26. The use of the pharmaceutical preparation as claimed in claim 25 for
producing a
drug for treating rheumatoid arthritis.
27. A pharmaceutical preparation comprising at least one compound as claimed
in
claim 1, with appropriate pharmaceutical excipients and at least one other
compound selected from the
group of
collagenase,
PDGF antagonists or
MMPs.
28. The use of the pharmaceutical preparation as claimed in claim 27 for
producing a
drug for improving wound healing.

Description

DEMANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE I)E CETTE DEMANDE OU CE BREVETS
COMPRI~:ND PLUS D'UN TOME.
CECI EST ~.E TOME 1 DE 2
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
THIS IS VOLUME 1 OF 2
NOTE: For additional vohxmes please contact the Canadian Patent Oi~ice.


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
Integrin receptor antagonists
The invention relates to novel compounds which bind to integrin receptors,
their preparation
and use.
Integrins are cell surface glycoprotein receptors which mediate interactions
between cells of
the same type and different cells, and between cells and extracellular matrix
proteins. They
are involved in physiological processes such as, for example, embryogenesis,
hemostasis,
wound healing, immune response and formation) maintenance of the tissue
architecture.
Disturbances of the expression of cell adhesion molecule genes, and
disturbances of
receptor function may contribute to the pathogenesis of a large number of
disorders such as,
for example, tumors, thromboembolic events, cardiovascular disorders,
pulmonary diseases,
disorders of the CNS, of the kidney, of the gastrointestinal tract or
inflammations.
Integrins are heterodimers each consisting of an a and a (3 transmembrane
subunit which
are connected noncovalently. To date, 16 different a and 8 different (3
subunits and 22
different combinations have been identified.
Integrin a~(33, also called vitronectin receptor, mediates adhesion to a large
number of ligands
- plasma proteins, extracellular matrix proteins, cell surface proteins - most
of which contain
the aminoacid sequence RGD (Cell, 1986, 44, 517-518; Science 1987, 238, 491-
497), such
as, for example, vitronectin, fibrinogen, fibronectin, von Willebrand factor,
thrombospondin,
osteopontin, laminin, collagen, thrombin, tenascin, MMP-2, bone sialoprotein
II, various viral,
parasitic and bacterial proteins, natural integrin antagonists such as
disintegrins, neurotoxins
- mambin - and leech proteins - decorsin, ornatin - and same non-RGD ligands
such as, for
example, Cyr-61, PECAM (L. Piali, J. Cell Biol. 1995, 130, 451-460; Buckley,
J. Cell Science
1996, 109, 437-445, J. Biol. Chem. 1998, 273, 3090-3096).
Several integrin receptors show cross-reactivity with ligands which contain
the RGD motif.
Thus, integrin anb(33, also called platelet fibrinogen receptor, recognizes
fibronectin,
vitronectin, thrombospondin, von Willebrand factor and fibrinogen.
Integrin aV(33 is expressed inter alia on endothelial cells, blood platelets,
monocyteslmacrophages, smooth muscle cells, some B cells, fibroblasts,
osteoclasts and
various tumor cells such as, for example, melanomas, glioblastomas, carcinomas
of the
lung, breast, prostate and bladder, osteosarcomas or neuroblastomas.


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
_2_
Increased expression is observed under various pathological conditions, such
as, for
example, in the prothrombotic state, in cases of vessel injury, tumor growth
or metastasis or
reperfusion and on activated cells, in particular on endothelial cells, smooth
muscle cells or
macrophages.
Involvement of integrin a"~i3 has been detected inter alia in the following
pathological states:
cardiovascular disorders such as atherosclerosis, restenosis after vessel
injury, and
angioplasty (neointima formation, smooth muscle cell migration and
proliferation) (J. Vasc.
Surg. 1994, 19, 125-134; Circulation 1994, 90, 2203-2206),
acute kidney failure (Kidney Int. 1994, 46, 1050-1058; Proc. Natl. Acad. Sci.
1993, 90, 5700-
5704; Kidney Int. 1995, 48, 1375-1385),
angiogenesis-associated microangiopathies such as, for example, diabetic
retinopathy or
rheumatoid arthritis (Ann. Rev. Physiol 1987, 49, 453-464; Int. Ophthalmol.
1987, 11, 41-50;
Cell 1994, 79, 1157-1164; J. Biol. Chem. 1992, 267, 10931-10934),
arterial thrombosis,
stroke (phase II studies with ReoPro, Centocor Inc., 8'" annual European
Stroke Meeting),
cancers such as, for example, in tumor metastasis or tumor growth (tumor-
induced
angiogenesis) (Cell 1991, 64, 327-336; Nature 1989, 339, 58-61; Science 1995,
270, 1500
1502),
osteoporosis (bone resorption after proliferation, chemotaxis and adhesion of
osteoclasts to
bone matrix) (FASEB J. 1993, 7, 1475-1482; Exp. Cell Res. 1991, 195, 368-375,
Cell 1991,
64, 327-336),
high blood pressure, psoriasis, hyperparathyroidism, Paget's disease,
malignant
hypercalcemia, metastatic osteolytic lesions, inflammation, heart failure,
CHF, and for
antiviral, antiparasitic or antibacterial therapy and prophylaxis (adhesion
and internalization).
Because of its key role, pharmaceutical preparations which contain low
molecular weight


CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-3-
integrin a~,a3 antagonists are of great therapeutic and diagnostic use inter
alia for the said
indications.
Advantageous a"~i3 integrin receptor antagonists bind to the integrin a~(33
receptor with
increased affinity.
Particularly advantageous a"(33 integrin receptor antagonists additionally
have increased
selectivity for integrin av(33 and have less effect on integrin am(33 by a
factor of at least 10,
preferably by a factor of at least 100.
An integrin a"~i3 antagonist effect has been shown, and a beneficial in vivo
effect has been
demonstrated, for a large number of compounds such as anti-a"(33 monoclonal
antibodies,
peptides containing the RGD binding sequence, natural RGD-containing proteins
(for
example disintegrins) and low molecular weight compounds (FEBS Letts 1991,
291, 50-54;
J. Biol. Chem. 1990, 265, 12267-12271; J. Biol. Chem. 1994, 269, 20233-20238;
J. Cell Biol
1993, 51, 206-218; J. Biol. Chem. 1987, 262, 17703-17711; Bioorg. Med. Chem.
1998, 6,
1185-1208).
WO 9708145 describes meta-guanidine, urea, thiourea or azacyclic aminobenzoic
acid
derivatives and their use as av(33 integrin receptor antagonists.
It is an object of the present invention to provide novel integrin receptor
antagonists with
advantageous properties.
We have found that this object is achieved by compounds of the formula I
A-E-G-L
where A, E, G and L have the following meanings:
L a structural element of the formula I~
~a R2
~~T zL
Rj


CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-4-
where
a is0or1,
T is a COOH group or a radical which can be hydrolyzed to COOH,
RZ is hydrogen, NHS02Rz', NHCORz' orNHCO0R22,
where
Rz' is a branched or unbranched, optionally substituted C~-Cs-alkyl, C3-C6-
cycloalkyl, C~-C4-alkyl-C3-C6-cycloalkyl radical, CS-C,2-bicycloalkyl or C6-
C~e-tricycloalkyl radical, an up to trisubstituted, with identical or
different
radicals, aryl, alkylaryl, hetarylalkyl radical or 3- to 6-membered,
saturated,
unsaturated or aromatic heterocycle which may contain up to three different
or identical heteroatoms O, N, S, it being possible for two radicals together
to be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle
which may contain up to three different or identical heteroatoms O, N, S,
and this ring can optionally be substituted, or another, optionally
substituted, saturated, unsaturated or aromatic ring can be fused to this
ring,
RZZ is a branched or unbranched, optionally substituted C~-Cg-alkyl radical or
an
optionally substituted aryl or alkylaryl radical,
R3 is hydrogen or -(CH2)b-(X)~-R3',
where
b is 0, 1, 2 or 3,
c is0or1,
X is -SOZ-, -S-, -O-, -CO-, -NH-SOZ-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-,
-CO-N(R3')-, -N(Rs,)-CO-, -SOZ-NH-, -SOZ-N(Rs,)- or-N(R3')-S02-,
R3' is hydrogen, a hydroxyl group, a branched or unbranched, optionally


CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
-5-
substituted C~_C~-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary substitution,
an optionally C~_C4-alkyl- or aryl-substituted CZ-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C~2-bicycloalkyl, C6-C~$-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted by up
to three identical or different radicals and which may contain up to three
different or identical heteroatoms O, N, S, C3-C8-cycloalkyl, aryl or hetaryl
radical, it being possible for two radicals together to be a fused, saturated,
unsaturated or aromatic carbocycle or heterocycle which may contain up to
three different or identical heteroatoms O, N, S, and the ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring,
and
R4 is hydrogen, or a branched or unbranched, optionally substituted C~-4-
alkyl,
C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
G a structural element of the formula I~
where
Rb
JN IG
)d
R
d is 0, 1 or 2,
R5 is hydrogen, a hydroxyl group, a branched or unbranched, optionally
substituted C,-Cs-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an
amino radical with primary or optionally secondary or tertiary substitution,
an optionally C~-C4-alkyl- or aryl-substituted CZ-C6-alkynyl or C2-C6-alkenyl
radical, a C5-C~2-bicycloalkyl, C6-C~8-tricycloalkyl radical or a 3- to 6-
membered, saturated or unsaturated heterocycle which is substituted by up
to three identical or different radicals and which may contain up to three
different or identical heteroatoms O, N, S, C3-CS-cycloalkyl, aryl or hetaryl


CA 02371604 2001-10-24
WO OOI66618 PCTIEP00103469
-6
radical, it being possible for two radicals together to be a saturated,
unsaturated or aromatic carbocycle or heterocycle which may contain up to
three different or identical heteroatoms O, N, S, and the ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can be fused to this ring, or the side chain of a natural amino
acid,
R6 is hydrogen or a branched or unbranched, optionally substituted C,-C4-
alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl radical,
E a structural element of the formula IE
-(NH)s (CHZ)~Q-(CH2)e-CO- I
where
a is 0, 1 or 2,
f is0or1,
g is0orl,
Q is a doubly linked, optionally substituted hetaryl radical, it being
possible for
finro substituents together to be a saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms O, N, S, and this ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring can
be fused to this ring,
A one of the structural elements of the formulae IAi to IAZo


CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
_7_
Rls Rls R16
R17 'N TA2 R17 N _ ~~~3
''' \~/
N N
W
Rl ~. ~ IAa 10 ~ IA5 la Q IA( 1 R ~N IA7
R ~N~
Rll Rll
~N IA9 Z= Z~~ N
CN' ' N~ I
R15 R15 Z2' Z1 A15
N IAI1 N IA12 IA13
N~.-- ~N
~ is Ris
R Rls
0
N IA~.a ~~C IA15 ~ IAis
H' C~N
p N
~ls H
w
ZAm N IAie N ~A19 I~2a
I
I I
H
where
R'°, R" are, independently of one another, hydrogen, -(CH2),,-(Y);-
R'°', or the two
radicals together are a 3- to 8-membered, optionally substituted, saturated,
unsaturated or aromatic N-heterocycle which may additionally contain two
other,
identical or different heteroatoms O, N or S,
where
h is 0, 1, 2 or 3,


CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
_g_
is0or1,
Y is -SOZ-, -S-, -O-, -CO-, -NH-S02-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-,
-CO-N(R~°~)-, -N(R'°')-CO-, -SOZ-NH-, -N(R'°')-SOZ- or -
SOZ-N(R'°')- and
R'°' is a hydroxyl group, a branched or unbranched, optionally
substituted C1-
C6-alkyl, C~-C4-alkoxy, -O-alkylaryl or -O-aryl radical, an amino radical with
primary or optionally secondary or tertiary substitution, an optionally C~-C4-
alkyl- or aryl-substituted Cz-C6-alkynyl or CZ-Cs-alkenyl radical, a C5-C~2-
bicycloalkyl, C6-C18-tricycloalkyl radical or a 3- to 6-membered, saturated or
unsaturated heterocycle which is substituted by up to three identical or
different radicals and which may contain up to three different or identical
heteroatoms O, N, S, C3~-cycloalkyl, aryl or hetaryl radical, it being
possible
for two radicals together to be a fused, saturated, unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or
identical heteroatoms 0, N, S, and the ring can optionally be substituted, or
another, optionally substituted, saturated, unsaturated or aromatic ring can
be fused to this ring,
R'2 is a branched or unbranched, optionally substituted C1-C4-alkyl,
alkylaryl, C3-C6-
cycloalkyl or C~-C4-alkyl-C3-C6-cycloalkyl radical or an optionally
substituted aryl
radical,
R'3 is hydrogen, -OH, -CN, -CONH2, a branched or unbranched, optionally
substituted Ci-C4-alkyl, C~-C4-alkoxy or -OCO-C,-C4-alkyl radical, or an
optionally
substituted alkylaryl, -O-alkylaryl, -OCO-aryl, -OCO-alkylaryl or -OCO-ally!
radical,
R'4 is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl,
alkyl
aryl, -COZ-C~-C4-alkyl, -C02-alkylaryl, -COZ-ally!, -CO-C,-Cø-alkyl, -CO-
alkylaryl or
-CO-ally! radical,
R'S is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl
radical
or an optionally substituted aryl or alkylaryl radical.
R'6, R" are, independently of one another, -NH2, halogen or a branched or
unbranched, optionally substituted C1-C4-alkyl or C,-C4-alkoxy radical or an
optionally substituted aryl radical,


CA 02371604 2001-10-24
WO 00!66618 PCTIEP00I03469
-g_
Z', Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or N
and the physiologically tolerated salts, prodrugs and the enantiomerically
pure or
diastereomerically pure and tautomeric forms.
T in the structural element L means a COOH group or a radical which can be
hydrolyzed to
COOH. A radical which can be hydrolyzed to COOH means a radical which is
converted into
a COOH group after hydrolysis.
A group which may be mentioned as an example of a radical T which can be
hydrolyzed to
COOH is
O
_~C_R1
in which R' has the following meaning:
a) OM, where M can be a metal ration such as an alkali metal ration such as
lithium,
sodium, potassium, the equivalent of an alkaline earth metal ration such as
calcium,
magnesium and barium, or an environmentally compatible organic ammonium ion
such as tertiary C~-C4-alkylammonium or an ammonium ion, such as, for example,
ONa, OK or OLi,
b) a branched or unbranched, optionally halogen-substituted C~-Ce-alkoxy
radical such as,
for example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-
methylpropoxy, 2-
methylpropoxy, 1,1-dimethylethoxy, in particular methoxy, ethoxy, 1-
methylethoxy,
pentoxy, hexoxy, heptoxy, octoxy, difluoromethoxy, trifluoromethoxy,
chlorodifluoro-
methoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 1,1,2,2-
tetrafluoroethoxy,
2,2,2-trifluoroethoxy, 2-chloro-1,1,2-trifluoroethoxy or pentafluoroethoxy
c) a branched or unbranched, optionally halogen-substituted C~-C4-alkylthio
radical such
as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-
methylpropylthio, 2-
methylpropylthio or 1,1-dimethylethylthio radical
d) an optionally substituted -O-alkylaryl radical such as, for example, -O-
benzyl


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-10-
e) R' also a radical of the formula -(O)m-N(R'e)(R'9), in which m is 0 or 1,
and R'e and R'9,
which may be identical or different, have the following meaning:
hydrogen,
C,-C8-alkyl, such as, for example, methyl, ethyl, propyl, 1-methylethyl,
butyl, 1-methyl-
propyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-
methylbutyl, 1,2-
dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl,
1-
methylpentyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 1,1-
dimethylbutyl,
2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-
trimethylpropyl, 1-
ethylbutyl, 2-ethylbutyl, heptyl or octyl,
C3-C6-alkenyl such as, for example, 2-propenyl, 2-butenyl, 3-butenyl, 1-methyl-
2-
propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-
butenyl,
2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-
butenyl, 3-
methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-
propenyl,
2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-
pentenyl,
3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-
pentenyl, 1-
methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-
pentenyl, 1,1-
dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-
dimethyl-3
butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-
butenyl, 2,3
dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-
butenyl, 2-ethyl
2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-
propenyl
and 1-ethyl-2-methyl-2-propenyl, in particular 2-propenyl, 2-butenyl, 3-methyl-
2-butenyl
and 3-methyl-2-pentenyl,
C3-C6-alkynyl such as, for example, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-
2-
propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-
butynyl, 1-
methyl-2-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 2-hexynyl, 3-
hexynyl, 4-
hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-2-pentynyl, 1-methyl-3-
pentynyl, 1
methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-
pentynyl, 4
methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-
dimethyl-3
butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-
3-butynyl
and 1-ethyl-1-methyl-2-propynyl, preferably 2-propynyl, 2-butynyl, 1-methyl-2-
propynyl
and 1-methyl-2-butynyl, in particular 2-propynyl,
C3-C8-cycfoalkyl, such as, for example, cyclopropyl, cyclobutyl, cyclopenfyl,
cyclohexyl


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-11 _
and cycloheptyl, cyclooctyl, it being possible for these alkyl, cycloalkyl,
alkenyl and
alkynyl groups each to be substituted,
phenyl, optionally substituted one or more times, for example one to three
times, by
halogen, nitro, cyano, C~-C4-alkyl, C1-C4-haloalkyl, C~-C4-alkoxy, C~-C4-
haloalkoxy or
C~-C4-alkylthio, such as, for example, 2-fluorophenyl, 3-chlorophenyl, 4-
bromophenyl,
2-methylphenyl, 3-nitrophenyl, 4-cyanophenyl, 2-trifluoromethylphenyl, 3-
methoxy-
phenyl, 4-trifluoroethoxyphenyl, 2-methylthiophenyl, 2,4-dichlorophenyl, 2-
methoxy-3-
methylphenyl, 2,4-dimethoxyphenyl, 2-vitro-5-cyanophenyl, 2,6-difluorophenyl
or R'$ and R'9 together form a C4-C~-alkylene chain which is closed to a ring,
is
optionally substituted, for example by C~-C4-alkyl and may contain a
heteroatom
selected from the group of oxygen, sulfur or nitrogen, such as, for example, -
(CHZ)a-,
-(CHz)s-~ -(CH2)s-, -(CHz)r~ -(CHZ)2-O-(CHz)2-, -CH2-S-(CH2)3-. -(CHz)z-O-
(CHZ)3-~ -NH-
(CH2)3-, -CHz-NH-(CHZ)2-, -CH2-CH=CH-CH2-, -CH=CH-(CH2)3-, -CO-(CHZ)2-CO- or
-CO-(CHz)3-CO-.
Preferred T radicals are -COOH, -CO-O-C~-Cs-alkyl or -CO-O-benryl.
A branched or unbranched C~-Cs-alkyl radical for R2' in the structural element
L means, for
example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-
methylpropyl, 1,1-
dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2-dimethylpropyl, 1,1-
dimethylpropyl,
2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl,
1,3-dimethylbutyl,
2,3-dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl,
1,1,2-
trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-
2-methylpropyl,
preferably methyl, ethyl, propyl, butyl or i-butyl.
A branched or unbranched C3-Cs-cycloalkyl radical for RZ' in the structural
element L means,
for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
A branched or unbranched C~-C4-alkyl-C3-Cs-cycloalkyl radical for R2' in
structural element L
means an abovementioned C3-Cs-cycloalkyl radical which is a substituent on a
C~-C4-alkyl
radical.
The C~-Cs-alkyl radicals, C3-Cs-cycloalkyl radicals or C~-C4-alkyl-C3-Cs-
cycloalkyl radical may
be substituted by up to 5 identical or different radicals selected from the
group of halogen,
aryl or hetaryl.


CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-12-
A C5-C,Z-bicycloalkyl radical for Rz' means, for example, indanyl, norbornyl
or camphyl, and
a C6-C,$-tricycloalkyl radical means, for example, adamantyl.
An up to trisubstituted, with identical or different radicals, aryl,
alkylaryl, alkylhetaryl radical or
3- to 6-membered, saturated, unsaturated or aromatic heterocycle which may
contain up to
three different or identical heteroatoms O, N, S, it being possible for two
radicals together to
be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which
may contain
up to three different or identical heteroatoms 0, N, S, and for the ring to
optionally be
substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring to be
fused to this ring for R2' in structural element L means, for example,
aryl radicals such as, for example, phenyl, 1-naphthyl or 2-naphthyl,
alkylaryl radicals such as, for example, benzyl or phenethyl,
alkylhetaryl radicals such as, for example, -CHZ-2-pyridyl, -CHz-3-pyridyl, -
CH2-4-pyridyl,
-CH2-2-thienyl, -CHr3-thienyl, -CHZ-2-thiazolyl, -CH2-4-thiazolyl, CH2-5-
thiazolyl, -CHZ-CHZ-2-
pyridyl, -CH2-CH2-3-pyridyl, -CH2-CHZ-4-pyridyl, -CHz-CHZ-2-thienyl, -CH2-CH2-
3-thienyl,
-CHZ-CHZ-2-thiazolyl, -CHz-CHZ-4.-thiazolyl, or -CH2-CH2-5-thiazolyl,
preferably -CHZ-2-
pyridyl, -CH2-2-thienyl, or-CHz-2-thiazolyl or
hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-
furyl, 3-furyl, 2-pyrrolyl,
3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazofyl, 2-
oxazolyl, 4-oxazolyl, 5-
oxazolyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-
pyrazolyl, 5-
pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-
imidazolyl, 5-imidazolyl,
3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-
pyridyl, 3-pyridyl, 4-
pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-
thiazolyl,
it being possible for the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals to be substituted by up to three identical or different radicals, for
example selected
from the following group:
-N02, -NHZ, -OH, -CN, -COOH, -COO-C,-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C,-C4-alkyl, C3-C6-cycloalkyl, C,-C4-alkoxy, C,-C4-
alkylthio, -O-CH2-
COO-C,-C4-alkyl, -NH-CO-C,-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOz-C,-C4-alkyl, -
SOz-NH-
C,-C4-alkyl, -N(C,-C4-alkyl)2, -NH-C,-C4-alkyl, or -SOZ-C,-C4-alkyl radical,
an optionally


CA 02371604 2001-10-24
WO 00/66618 PCTIEP00l03469
-13-
substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-S02-phenyl, -S02-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benryl, -NH-SOZ-benryl, -S02-NH-benryl, an optionally
substituted radical -
S02-NT'Tz or -CO-NT'Tz where the two radicals T' and Tz may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms 0, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals for RZ' are C~-C4-alkyl, C3-C6-cycloalkyl, -COOH, -COOMe, -CF3, -CN,
C~-C4-alkoxy,
-SCH3, -O-CHz-COOH, phenyl, -SOZCH3, -NO2, -OH, -NHz, -N-pyrrolidinyl, -N-
piperidinyl, -N-
morpholinyl, -N-piperazinyl, -NH-C~-C4-alkyl, -N(C~-C4-alkyl)z, F, CI, Br or
I.
Preferred substituents on the aryl radicals, alkylaryl radicals, alkylhetaryl
radicals and hetaryl
radicals for RZ' in which two radicals together are a fused, saturated,
unsaturated or aromatic
carbocycle or heterocycle which may contain up to three different or identical
heteroatoms 0,
N, S, and the ring can optionally be substituted or another optionally
substituted ring can be
fused to this ring, are the following doubly linked structural elements:
.>; O . /
>:
. O ,:'~o ~ '
H
.~~~S ~-N
,'~...~NS ~/ ~/ '/
A branched or unbranched C~-C~-alkyl radical for R22 in structural element L
means, for
example, the C~-C6-alkyl radicals mentioned above for Rz', preferably 1,1-
dimethylethyl.
Examples of aryl radicals for R~ in structural element L are phenyl, 1-
naphthyl or 2-naphthyl,
preferably phenyl; alkylaryl radicals for R22 in structural element L are
preferably benzyl or
phenethyl.
Suitable substituents on the C~-C6-alkyl radical, aryl radicals or alkylaryl
radicals for R2z in
structural element L are the substituents mentioned above for the aryl
radicals, the alkylaryl
radicals, alkylhetaryl radicals and hetaryl radicals of RZ'.


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-14-
In the radical R3 in structural element L, the index b can be 0, 1, 2 or 3,
preferably 0, 1 or 2,
and the index c can be 0 or 1. The radical X is a doubly linked radical
selected from the
group of -S02-, -S-, -O-, -CO-, -NH-S02-, -O-CO-, -CO-O-, -NH-CO-, -CO-NH-, -
CO-N(R3')-,
-N(R3')-CO-, -SOZ-NH-, -SOZ-N(R3')- or -N(R3')-SOZ-. In the case of radicals
which are
disubstituted by R3', the two R3' radicals can be identical or different.
A branched or unbranched C~-C6-alkyl radical for R3' in structural element L
means, for
example, methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-
methylpropyl, 1,1-di-
methylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 1,2~limethylpropyl, 1,1-
dimethylpropyl, 2,2-
dimethylpropyl, 1-ethylpropyl, hexyl, 1-methylpentyl, 1,2-dimethylbutyl, 1,3-
dimethylbutyl, 2,3-
dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-
trimethylpropyl,
1,2,2-trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl or 1-ethyl-2-methylpropyl,
preferably methyl,
ethyl, propyl, butyl, iso-propyl, sec-butyl and tert-butyl.
A branched or unbranched C~-C4-alkoxy radical for R3' in structural element L
means, for
example, methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-
methylpropoxy or 1,1-dimethylethoxy, in particular methoxy, ethoxy or 1-
methylethoxy.
Examples of -O-alkylaryl or -O-aryl radicals are -O-phenyl, -O-1-naphthyl, -O-
2-naphthyl or
-O-benzyl.
The C,-C6-alkyl, C,-C4-alkoxy radicals of R3' in structural element L can be
substituted by up
to five identical or different radicals selected from the group of halogen,
aryl or hetaryl.
Substituted -O-alkylaryl or -O-aryl radicals mean, for example, the
abovementioned -O-alkyl-
aryl or -O-aryl radicals, it being possible for the aryl moiety to be
substituted by up to three
identical or different radicals selected from the following group:
-NO2, -NHz, -OH, -CN, -COOH, -C00-C~-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C,-C4-alkyl, C3-C6-cycloalkyl, C~-C4-alkoxy, C,-C4-
alkylthio, -0-CHz-
COO-C~-C4-alkyl, -NH-CO-C~-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOz-C~-C4-alkyl, -
SOZ-NH-
C,-C4-alkyl, -N(Ci-C4-alkyl)2, -NH-C~-C4-alkyl, or -SOZ-C~-C4-alkyl radical,
an optionally
substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-phenyl, -SOZ-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -SOz-NH-benzyl, an optionally
substituted radical
-SOz-NT'T2 or -CO-NT'TZ where the two radicals T' and T2 may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or


CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
-15-
heterocycle which may contain up to three different or identical heteroatoms
0, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
An amino radical with primary or optionally secondary or tertiary substitution
for R3' in
structural element L means a primary amino radical -NH2, a secondary amino
radical
-NH(R3") or a tertiary amino radical -N(R3")(Ral2), where
R3" and R3'2 can be, independently of one another, C~-C4-alkyl or C3-C6-
cycloalkyl as
mentioned above, optionally substituted aryl, preferably phenyl, alkylaryl,
preferably benzyl, -
CO-C~-C4-alkyl, preferably -CO-CH3 or -CO-aryl, preferably -CO-phenyl.
In the case where c = 1 and X = CO, the corresponding amide residues result.
Cyclic tertiary amide residues or amino radicals result in the case where R3'
is one of the
heterocyclic systems described below, which is linked via the ring nitrogen to
X = CO or
directly. Examples of preferred amide residues -X-R3' are
0 0 _
N N ~ VO
A C2-Cs-alkynyl or C2-C6-alkenyl radical which is optionally substituted by C,-
C4-alkyl or aryl
for R3' in the structural element L means, for example, CZ-Cs-alkynyl radicals
such as, for
example, ethynyl, 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-
pentynyl, 3-
pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-methyl-2-
butynyl, 1,1-
dimethyl-2-propynyl, 1~thyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-
hexynyl, 1-methyl-
2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-
methyl-4-
pentynyl, 3-methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl,
1,1-dimethyl-3-
butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 1-ethyl-2-butynyl, 1-
ethyl-3-butynyl, 2-
ethyl-3-butynyl or 1-ethyl-1-methyl-2-propynyl, preferably 2-propynyl or
ethynyl
or C2-Cs-alkenyl radical such as, for example, vinyl, 2-propenyl, 2-butenyl, 3-
butenyl, 1-
methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-
methyl-2-
butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-Methyl-
3-butenyl, 3-
methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-2-
propenyl, 2-
hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 2-methyl-2-
pentenyl, 3-


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-16-
methyl-2-pentenyl, 4-methyl-2-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-
pentenyl, 1-methyl-
4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-
dimethyl-2-
butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-
butenyl, 1,3-dimethyl-
2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-2-
butenyl, 2,3-
dimethyl-3-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-
ethyl-3-butenyl,
1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl or 1-ethyl-2-methyl-2-
propenyl, in
particular 2-propenyl or vinyl
which can be substituted by optionally substituted Ci-C4-alkyl radicals, or
aryl radicals as
mentioned above, preferably phenyl, such as, preferably, phenylethynyl or
phenylethenyl.
A C~-C~2-bicycloalkyl radical for R3' means, for example, indanyl, norbornyl
or camphyl, and
a C6-C,B-tricycloalkyl radical means, for example, adamantyl.
A 3-to 6-membered, saturated or unsaturated heterocycle which is substituted
by up to three
identical or different radicals and which may contain up to three different or
identical
heteroatoms O, N, S, C3-C8-cycloalkyl, aryl or hetaryl radical, it being
possible for two
radicals together to be a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
for the ring to
optionally be substituted, or another, optionally substituted, saturated,
unsaturated or
aromatic ring to be fused to this ring, for R3' in structural element L means,
for example
3- to 6-membered, saturated or unsaturated heterocycles which may contain up
to three
different or identical heteroatoms O, N, S, such as N-pyrrolidinyl, N-
piperidinyl, N-
hexahydroazepinyl, N-morpholinyl or N-piperazinyl, it being possible for free
amine protons in
heterocycles with free amine protons, such as, for example, N-piperazinyl, to
be replaced by
conventional amine protective groups such as, for example, methyl, benzyl, Boc
(tert-
butoxycarbonyl), Z (benzyloxycarbonyl), tosyl, -S02-C~-C4-alkyl, -SOZ-phenyl
or -S02-benzyl,
C3-C8-cycloalkyl radicals as described above for Rz',
aryl radicals such as, for example, phenyl, 1-naphthyl or 2-naphthyl or
hetaryl radicals such as, for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-
furyl, 3-furyl, 2-pyrrolyl,
3-pyrrolyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-
oxazolyl, 4-oxazolyl, 5-
oxazofyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 6-pyrimidyl, 3-pyrazolyl, 4-
pyrazolyl, 5-
pyrazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 2-imidazolyl, 4-
imidazolyl, 5-imidazolyl,


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-17-
3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl or 6-pyridazinyl, preferably 2-
pyridyl, 3-pyridyl, 4-
pyridyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-thiazolyl, 4-thiazolyl or 5-
thiazolyl,
it being possible for the heterocyclic, C3-C8-cycloalkyl, aryl and hetaryl
radicals optionally to
be substituted by up to three identical or different radicals, for example
selected from the
following group:
-NOz, -NH2, -OH, -CN, -COOH, -COO-C~-C4-alkyl, halogen, a branched or
unbranched,
optionally substituted C~-C4-alkyl, C3-C6-cycloalkyl, G~-C4-alkoxy, C~-C4-
alkylthio, -O-CHZ-
COO-C~-C4-alkyl, -NH-CO-Ci-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-S02-C,-C4-alkyl, -
SOZ-NH-
C~-C4-alkyl, -N(C~-C4-alkyl)2, -NH-C~-C4-alkyl, or -SOZ-C~-C4-alkyl radical,
an optionally
substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOrphenyl, -SOZ-NH-phenyl, -NH-
CO-
benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -S02-NH-benzyl, an optionally
substituted radical
-SOz-NT'Tz or -CO-NT'TZ where the two radicals T' and T2 may form a cyclic
amine, or a 3-
to 6-membered, optionally substituted, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, or two
radicals together are a fused, saturated, unsaturated or aromatic carbocycle
or heterocycle
which may contain up to three different or identical heteroatoms O, N, S, and
the ring can
optionally be substituted or another, optionally substituted ring can be fused
to this ring.
Preferred substituents of the heterocyclic, C3-C$-cycloalkyl, aryl and hetaryl
radicals for R3'
are C~-C4-alkyl, -COOH, -COOMe, -CF3, -CN, Ci-C4-alkoxy, -SCH3, -O-CH2-COOH, -
phenyl,
-SOzCH3, -N02, -OH, -NHz, -N-pyrrolidinyl-, -N-piperidinyl, -N-morpholinyl, -N-
piperazinyl,
-NH-C~-C4-alkyl, -N(C~-C4-alkyl)Z, F, CI, Br or I.
Preferred substituents of the heterocyclic, C3-C8-cycloalkyl, aryl and hetaryl
radicals for R3' in
which two radicals together are a fused, saturated, unsaturated or aromatic
carbocycle or
heterocycle which may contain up to three different or identical heteroatoms
O, N, S, and the
ring can optionally be substituted, or another, optionally substituted ring
can be fused to this
ring, are the following, doubly linked structural elements:
,
. r
~ , ,
° %'o ; ~.
H
~S .YN
. S ,r ;~ ;..
.~~'" N


CA 02371604 2001-10-24
WO 00!66618 PCTJEPOOJ03469
-18
Examples of the resulting condensed ring systems for R3' are, for example, the
corresponding dioxolanyls, benzopyrrolyls, benzofuryls, benzothienyls or
fluorenyls,
A branched or unbranched, optionally substituted C~-C4-alkyl radical for R4 in
structural
element L means, for example, methyl, ethyl, propyl, i-propyl, butyl, t-butyl
or i-butyl,
preferably methyl.
A branched or unbranched, optionally substituted C3-C6-cycloalkyl radical for
R4 in structural
element L means the radicals mentioned above for Rz', which are optionally
substituted by
up to 5 radicals such as halogen or aryl, preferably cyclohexyl, cyclopentyl
or cyclopropyl.
C3-C~-alkenyl or C3-C6-alkynyl radicals for R4 in structural element L are the
radicals
mentioned above for R'8 or R'9, preferably ally! or propargyl.
Particularly preferred radicals for R4 are hydrogen, methyl, cyclopropyl,
ally! or propargyl, and
hydrogen is very particularly preferred.
Preferred structural elements L have a = 1, so that a (3-amino acid represents
the preferred
basic structure of the structural element L. In particularly preferred
structural elements L,
either the radical R2 = hydrogen and the radical R3 may vary widely as
described above, or
the radical R3 = hydrogen and the radical RZ may vary widely as described
above. Very
particularly preferred structural elements L have R2 = H and R3 may vary
widely as described
above, or R3 = H and RZ = -NHZ, -NH-SOZ-phenyl or -NH-SOZ-benzyl, where Z is
the
benzyloxycarbonyl protective group.
In structural element G of the formula I~, RS means hydrogen and,
independently of R3' in
structural element L, the same radicals as described above for R3' or another
side chain of a
natural amino acid. Preferred R5 radicals are hydrogen, methyl, ethynyl or
methyl-substituted
ethynyl, and hydrogen is particularly preferred.
Rs means, independently of R4, the same radicals as described above for R4.
Preferred Rs
radicals are hydrogen, methyl, ally!, propargyl or cyclopropyl, and hydrogen
is particularly
preferred.
In structural element E of the formula IE, Q means a doubly linked hetaryl
radical which is
optionally substituted by up to three other radicals, it being possible where
appropriate for two


CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
-19
radicals together to be a saturated, unsaturated or aromatic carbocycle or
heterocycle which
may contain up to three different or identical heteroatoms O, N, S, and the
ring can optionally
be substituted, or another, optionally substituted, saturated, unsaturated or
aromatic ring can
be fused to this ring.
A hetaryl radical preferably means a 5- or 6-membered aromatic heterocyclic
system which
may contain up to three different or identical heteroatoms O, N, S, it being
possible for the
free amine protons in heterocycles with free amine protons, such as, for
example, imidazolyl,
triazolyl, pyrazolyl or pyrrolyl, to be replaced by conventional amine
protective groups such
as, for example, methyl, benryl, Boc (tent-butoxycarbonyl), Z
(benzyloxycarbonyl), tosyl, -
S02-C~-Ca-alkyl, -SOz-phenyl or -S02-benzyl.
Preferred hetaryl radicals Q which may be listed are the following structures
where the points
of linkage are indicated by a bond line:
N.
S
N-N ~ ~
N 11 ~~ %r '1
S ~N ~O. ~'~ /C,N,.
H H
~~- ~~~
N N N S
Particularly preferred hetaryl radicals Q which may be listed are the
following structures
where the fixed positions of the points of linkage are indicated by a bond
line, and the
structures can be incorporated in both orientations:


CA 02371604 2001-10-24
WO 00!66618 PCTIEP00l03469
-20
I ! /
0 N~ 0
H
N_~ ~N N I~ l~ N N
O ~S~ ~S, ~Q
H
'W. ~ N ~ N
( i ( i ~ ~ ~ l1~ f'
N N N N
H H
Very particularly preferred hetaryl radicals Q which may be listed are the
following structures
where the fixed positions of the points of linkage are indicated by a bond
line, and the
structures can be incorporated in both orientations:
S S O O H N
~,~~
~ 'E'S'N x
As mentioned above, the free amine protons of imidazolyl, pyrazolyl, triazolyl
or pyrrolyl in
these preferred and particularly preferred structures can also be replaced by
conventional
amine protective groups such as, for example, methyl, benzyl, Boc (tert-
butoxycarbonyl), Z
(benzyloxycarbonyl), tosyl, -S02-C,-Ca-alkyl, -S02-phenyl or -SOZ-benzyl,
Preferred substitutents of the hetaryl radicals are, independently of one
another, one or two
radicals selected from the group of -CN, halogen, preferably CI or F, C~-C4-
alkyl, preferably
methyl, C~-C4-haloalkyl, preferably trifluoromethyl, C,-Ca-alkoxy, preferably
methoxy, -NH-C,-
C4-alkyl or aryl, preferably phenyl.
The structural element A is one of the structural elements of the formula
IA'to IA2o


CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
-21
Rls Rie Ris
R17 / IA1 Rl7 ~ n2 R17 " \ IA3
N N
0 Ri '
S
R1 ~, ~ IA4 R'- \N I, ZA5 R1 ~ p
Rii
~N IAs ~N IA9 Z/~a N IAlo
rt-~ N
Rls Ris ZZ\Zi Nls
R
N~ /All ( ~~A12 ~A13
N
N N
Ri s Ri 5 N
Ris
O
N xAl4 H3C N IA15 ~ ~ zAl6
O' _N
Rls H
N jAl7 N IA18 _N Inl9 In20
O~N
x
where the structural elements of the formula IA', IA2, IA3, IA~, IAS, IAe,
IA'°, or ~,q'3 are preferred,
and the structural element of the formula IA4
0
R1 1
4
A
R11
is particularly preferred, for the structural element A.


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-22
The radicals R'° and R" are, independently of one another and
independently of R3, the
radicals described above for R3 in structural element L, preferably C~-C4-
alkyl, C3-C8-cyclo-
alkyl, C,-Ca-alkyl-C3-Ce-cycloalkyl, aryl, alkylaryl, hetaryl or alkylhetaryl,
it being possible for
the aryl, alkylaryl, hetaryl and alkylhetaryl radicals to carry up to three
identical or different
radicals of the group F, CI, Br or I, C~-C4-alkyl, C3-C6-cycloalkyl, -COOH, -
COOMe, -CF3,
-CN, Ci-C4-alkoxy, -SCH3, -O-CHZ-COOH, phenyl, -S02CH3, -N02, -OH, -NH2, -N-
pyrrolidinyl, -N-piperidinyl, -N-morpholinyl, -N-piperazinyl, -NH-C~-C4-alkyl,
-N(C~-C4-alkyl)z,
-NH-CO-C~-C4-alkyl, -CO-NH-C,-C4-alkyl, -NH-SOZ-C~-C4-alkyl, -SOZ-NH-C~-C4-
alkyl, or
-S02-C~-C4-alkyl, optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-
phenyl,
-SOz-NH-phenyl, -NH-CO-benzyl, -CO-NH-benzyl, -NH-SO2-benzyl, -SOZ-NH-benzyl,
optionally substituted -SOz-NT'T2 or -CO-NT'T2, where the two radicals T' and
T~ may form
a cyclic amine,
or the two radicals R'° and R" together a 3- to 8-membered, optionally
substituted,
saturated, unsaturated or aromatic N-heterocyclic system which may
additionally contain two
other identical or different heteroatoms O, N, or S, such as, for example,
pyrrolidinyl,
piperidinyl, hexahydroazepinyl, piperazinyl or morpholinyl.
R'2 is a branched or unbranched, optionally substituted C~-C4-alkyl,
alkylaryl, C3-C6-cycloalkyl
or C~-C4-alkyl-C3-C6-cycloalkyl radical or an optionally substituted aryl
radical as described
above for Rz'.
A branched or unbranched, optionally substituted C~-C4-alkoxy or -O-alkylaryl
radical for R'3
means the corresponding radicals as described above for R3', preferably
methoxy or
benzyloxy. The radicals -OCO-C,-C4-alkyl-, -OCO-aryl-, -OCO-alkylaryl- or -OCO-
allyl- are
comprised of the group -OCO- and the C~-C4-alkyl, aryl or alkylaryl radicals
described above
under R3', or the allyl radical.
Preferred R'3 radicals are hydrogen, -OH, -O-benzyl, -OCO-phenyl, -OCO-benzyl,
-OCO-
allyl, -CN or-CO-NH2.
Analogously, the radicals -C02-C~~-alkyl-, -COz-alkylaryl-, -COz-allyl-, -CO-
C,-C4-alkyl-, -CO
alkylaryl- or -CO-allyl for the radical R'4 are composed of the group -C02- or
-CO- and the
C~-C4-alkyl, aryl radical described above under R3' or the allyl radical.
Preferred radicals for
R'4 are hydrogen, methyl, benzyl, -COO-benzyl, -COO-allyl, -CO-benzyl or -CO-
allyl.
R'S is hydrogen, a branched or unbranched, optionally substituted C~-C4-alkyl
radical or an


CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-23
optionally substituted aryl or alkylaryl radical as described above for R~' or
R4. Preferred R'S
radicals are hydrogen, methyl, benzyl or phenyl.
R's, R" are, independently of one another, -NH2, halogen, such as CI, Br, I or
F or a
branched or unbranched, optionally substituted C~-C4-alkyl or C,-C4-alkoxy or
optionally
substituted aryl radical as described above for R3', preferably NH2, CI, F,
methyl, methoxy or
phenyl.
Z', Z2, Z3, Z4 are, independently of one another, CH, C-CH3, C-OCH3, C-CI or
N, it being
preferred that Z' and Z2 or ZZ and Z3 or Z3 and Z4 are not simultaneously N.
Unless specified in detail, substituted aryl, alkylaryl, hetaryl or
alkylhetaryl radicals in the
description mean aryl, alkylaryl, hetaryl or alkylhetaryl radicals which may
be substituted by
up to three identical or different radicals selected from the following group:
-NO2, -NHz, -OH, -CN, -COOH, -O-CH2-COOH, -COO-C1-C4-alkyl, halogen, a
branched or
unbranched, optionally substituted C~-C4-alkyl, C3-Cs-cycloalkyl, C~-C4-
alkoxy, C~-C4-alkyl-
thio, -O-CH2-COO-C~-C4-alkyl, -NH-CO-Ci-C4-alkyl, -CO-NH-C~-C4-alkyl, -NH-SOZ-
C,-C4-
alkyl, -S02-NH-C~-Ca-alkyl, -N(Ci-C4-alkyl)z, -NH-C~-C4-alkyl, or -SOz-Ci-C4-
alkyl radical, an
optionally substituted -NH-CO-phenyl, -CO-NH-phenyl, -NH-SOZ-phenyl, -S02-NH-
phenyl,
-NH-CO-benzyl, -CO-NH-benzyl, -NH-S02-benzyl, -S02-NH-benzyl, an optionally
substituted
radical -S02-NT'T2 or -CO-NT'TZ where the two radicals T' and T2 may form a
cyclic amine,
or a 3- to 6-membered, optionally substituted, saturated, unsaturated or
aromatic carbocycle
or heterocycle which may contain up to three different or identical
heteroatoms O, N, S, or
two radicals together are a fused, saturated, unsaturated or aromatic
carbocycle or hetero-
cycle which may contain up to three different or identical heteroatoms O, N,
S, and the ring
can optionally be substituted or another, optionally substituted ring can be
fused to this ring.
The compounds of the formula I and also the intermediates for their
preparation may have
one or more asymmetric substituted carbon atoms. The compounds may be in the
form of
pure enantiomers or pure diastereomers or mixture thereof. It is preferred to
use an
enantiomerically pure compound as active ingredient.
The compounds of the formula I may also be in the form of physiologically
tolerated salts.
The compounds of the formula I may also be in a prodrug form in which the
compounds of
the formula I are liberated under physiological conditions. Reference may be
made herd for


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-24
example to the group T in structural element L, which in some cases contains
groups which
can be hydrolyzed under physiological conditions to the free carboxyl group.
Derivatized
structural elements A which liberate the structural element A under
physiological conditions
are also suitable.
In a preferred embodiment of the compounds of the formula I, the indices a, e,
f and g and
the heterocycle Q are chosen so that the distance between the group T and the
structural
element A is from 10 to 14 atomic linkages, preferably 11 to 13 atomic
linkages, along the
shortest possible route along the molecule backbone.
Further preferred compounds of the formula I have the preferred structural
elements A of the
formula IA', IqZ, Ip3, Iq°, IgS, IqB, IA'° or IA'3 whsle the
structural elements E, G and L may vary
widely as described above.
Further preferred compounds of the formula I have the particularly preferred
structural
element A of the formula Iq4, while the structural elements E, G and L may
vary widely as
described above.
Particularly preferred compounds of the formula I have the preferred
structural elements A of
the formula Iq', Iq~, Iq3, Iq°, IqS, IAe, IA'° or Iq'3 and the
preferred region of the structural
element L, while the structural elements E and G may vary widely as described
above.
Further particularly preferred compounds of the formula I have the
particularly preferred
structural element A of the formula Iq4 and the preferred region of the
structural element L,
while the structural elements E and G may vary widely as described above.
Further particularly preferred compounds of the formula I have the preferred
structural
element A of the formula Iq4 and the preferred region of the structural
element E, while the
structural elements L and G may vary widely as described above.
Very particularly preferred compounds of the formula I have the preferred
structural element
A of the formula Iq4, the preferred region of the structural element E and the
preferred region
of the structural element L, while the structural element G may vary widely as
described
above.
Further very particularly preferred compounds of the formula I have the
preferred region of
the structural element A, the preferred region of the structural element E and
the preferred,


CA 02371604 2001-10-24
WO OOI66618 PCTIEP00103469
-25
region of the structural element G, while the structural element L may vary
widely as
described above.
Extremely preferred compounds of the formula I have the preferred structural
element A of
the formula IA" and the preferred regions of the structural elements E, G and
L.
Very preferred compounds of the formula I are listed in the following table,
where "compound
number" stands for the number of an individualized compound A-E-G-L of the
formula I, the
compound number and the respective compound are separated by a colon, and the
meaning
of the abbreviations of the structural elements A-E-G-L is explained after the
table.


CA 02371604 2001-10-24
WO 00166618 PGTIEP00103469
-26
Compound number: A-E-G-L
1: bhs-25thiaz-nmgly-betaoxaz


2: phhs-24thiaz-bala-betabph


3: bhs-25thiaz-ser-betapy


4: thazep-24thiaz~ly-beta13bendi


5: bim-24thiaz-gly-betatrif


6: bhs-24thioph-gly-betapyee


7: bhs-me25thioph-ala-beta34meoph


8: tolhs-24thioph-gly-betafbph


9: tolhs-24thioph-gly-betameph


10: bim-me24thiaz-bala-betaph


11: bhs-me25thioph-leu-beta34meoph


12: ibhs-24thioph-gly-betathiome


13: bhs-nme35pyr-gly-betabthioph


14: tolhs-nme35pyr-gly-betafu2


15: bhs-ithiadiaz-gly-betahmofu


16: phhs-nme35pyr-bala-betacph


17: impy-24thiaz-bala-betafu3


18: tolhs-25methiaz-bala-psdaptb


19: sabhs-25thiaz-gly-psdap


20. bhs-24thioph-gly-betadcphtb


21: 2py-nme35pyr-leu-psdap


22: bhs-nme35pyr-gly-aspbzla


23: phhs-me24thiaz-gly-zdap


24: bhs-25thiaz-bala-betameph


25: phhs-me24thiaz-ala-beta34meoph


26: tolhs-25methiaz-gly-beta34meoph


27: ibhs-ithiadiaz-gly-betafbph


28: tolhs-ithiadiaz-bala-asppha


29: phhs-ithiadiaz-baia-betaamibe


30: tolhs-24thioph-bala-betabmph


31: phhs-25methiaz-bala-betaol


32: bhs-25oxaz-bala-betamethi


33: ibhs-24thiaz-bala-betahni


34: gua-24thiaz-gly-betaftrif


35: bhs-24thiaz-gly-betafphe




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
_27_
36: tolhs-oxadiaz-gly-psdaptb


37: phhs-25methiaz-bala-betatbuph


38: bhs-24thiaz-nmgly-betathio3


39: phhs-24thioph-gly-betatos


40: 2py-thiadiaz-leu-psdap


41: dhim-35py-gly-betameph


42: bhs-ithiadiaz-gly-aspaba


43: phhs-oxadiaz-gly-beta4bph


44: bhs-25thiaz-gly-csdap


45: ibhs-25thiaz-gly-betahph


46: phhs-25methiaz~ly-betahdbph


47: bim-me25thioph-gly-betaph


48: ibhs-ithiadiaz-bala-beta3quin


49: tolhs-oxadiaz-gly-betadhbfu


50: bhs-oxadiaz-leu-psdap


51: impy-24thioph-bala-betainyl


52: bhs-25methiaz-ala-beta23meoph


53: phhs-24thiaz-gly-betabnaphth


54: impy-42nmeim-bala-betathiome


55: bim-35thioph-ala-betadcph


56: 2py-me24thiaz-gly-betapy


57: phhs-24thioph-bala-betaimid


58: phhs-24thioph-gly-betadhbfu


59: phhs-nme35pyr-bala-betaibph


60: bhs-25thiaz-ser-betameph


61: tolhs-25thiaz-bala-zdap


62: bim-25thiaz-gly-betadcph


63: 2pmhs-42nmeim-gly-betaamibe


64: 2py-24thioph-gly-beta3quin


65: bhs-25methiaz-gly-betamethioph


66: tolhs-ithiadiaz-gly-betafbph


67: phhs-25methiaz-gly-betamethi


68: ibhs-24thiaz-gly-betadtrif


69: bhs-24thioph-gly-betabthioph


70: tolhs-25oxaz-gly-betabmph


71: ibhs-ithiadiaz-bala-suabu


72: bhs-42oxaz-gly-betapy




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-28
73: tolhs-ithiadiaz-g1y-betapyr


74: 2py-24im-g ly-psdap


75: thpy-24thiaz-gly-betadcph


76: phhs-24thiaz-gly-betampy


77: bhs-25methiaz-bala-betadito


78: phhs-25methiaz-bala-suabu


79: bhs-25thiaz-bala-beta23meoph


80: bhs-oxadiaz-leu-betapy


81: tolhs-25oxaz-gly-betabnaphth


82: dhim-25thiaz-ala-zdap


83: tolhs-ithiadiaz-gly-betaimid


84: bhs-ithiadiaz-bala-betaoxaz


85: bim-25thioph-ala-betameph


86: phhs-25oxaz-bala-beta4bph


87: bhs-nme35pyr-nmgly-betainyl


88: phhs-24thiaz-bala-betacbph


89: bhs-25oxaz-bala-betaet


90: bhs-24thioph-bala-betabmph


91: bhs-25oxaz-ala-betaanaphth


92: ibhs-ithiadiaz-gly-betathiobe


93: bhs-25thiaz-bala-betadito


94: 2py-nme35pyr-bala-betapy


95: tolhs-25oxaz-bala-beta3quin


96: bhs-25thiaz-gly-beta23meoph


97: 2py-25methiaz-gly-betadito


98: ibhs-nme35pyr-bala-betahni


99: tolhs-nme35pyr-gly-betadmph


100:ibhs-ithiadiaz-bala-betabdimo


101:2py-24thiaz-gly-aspibua


102:ibhs-nme35pyr-bala-betacbph


103;bhs-24thiazme-gly-zdap


104:bhs-24thioph-bala-betaol


105:2py-24im-gly-zdap


106:tolhs-25methiaz-gly-betapytb


107:tolhs-ithiadiaz-gly-psdap


108:phhs-25thiaz-bala-betabthioph


109:bhs-nme35pyr-gly-betafph




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-29
110:bhs-25methiaz-ala-betadhbfu


111:bim-25fur-ala-psdap


112:2pmhs-24thiaz-gly-betapy


113:bhs-24thiaz-bala-betaphethio


114:bhs-25methiaz-bala-betapytb


115:bhs-25methiaz-bala-betambiph


116:ibhs-25thiaz-gly-betainyl


117:phhs-nme35pyr-bala-betabthioph


118:bhs-25thiaz-bala-betacph


119:bim-26py-ala-betadcph


120:phhs-24thioph-gly-betaphethio


121:gua-24thiaz-gly-betabthioph


122:phhs-24thioph-bala-betaph


123:bhs-25thiaz-gly-betaibph


124:ibhs-nme35pyr-bala-betathio3


125:tolhs-oxadiaz-gly-betapy


126:tolhs-nme35pyr-bala-beta4bph


127:2py-me24oxaz-gly-betadcph


128:tolhs-25methiaz-bala-psdapee


129:bhs-ithiadiaz-gly-suabu


130:ibhs-25methiaz-bala-beta3quin


131:phhs-25oxaz-gly-betaipr


132:bim-53pyrazo-ala-betadcph


133:tolhs-25oxaz-gly-betapym


134:phhs-25oxaz-gly-betathiobe


135:phhs-me24thioph-ala-betaph


136:tolhs-me25thiaz-leu-betapy


137:hs-25thiaz-bala-betapy


138:bim-42nmeim-leu-betapy


139:tolhs-nme35pyr-bala-betampy


140:bhs-24thioph-gly-betahdcph


141:ibhs-25oxaz-gly-betaimid


142:bhs-oxadiaz-gly-csdap


143:ibhs-25oxaz-gly-betadtrif


144:2py-53pyrazo-ala-betapy


145:phhs-nme35pyr-gly-betahdbph


146:tolhs-oxadiaz-bala-zdapch




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-30
147:phhs-oxadiaz-bala-betapych


148:bim-24thioph-gly-betatrif


149:tolhs-25methiaz-bala-betapyr


150:2py-24thiaz-ala-betapy


151:bhs-25thiaz-gly-betapytb


152:tolhs-25oxaz-gly-zdapch


153:bhs-25methiaz-ala-betadcph


154:ibhs-25methiaz-gly-betatos


155:tolhs-25thiaz-gly-beta35dbph


156:bim-me24thioph-leu-betadcph


157:bim-nme35pyr-gly-aspbzla


158:ibhs-24thioph-bala-ibsdap


159:gua-24thiaz-gly-betal3bendi


160:2py-25meth iaz-g ly-psda
p


161:2py-24thiaz-bala-asppha


162:ibhs-ithiadiaz-bala-betaanaphth


163:bhs-nme35pyr-ala-betameph


164:tolhs-oxadiaz-gly-betapym


165:phhs-ithiadiaz-gly-betaph


166:phhs-25methiaz-bala-betadcphtb


167:2pmhs-24thiaz-gly-betaph


168:gua-24oxaz-gly-betafbph


169:bhs-25oxaz-phg-betapy


170:bhs-25methiaz-bala-betahdbph


171:2py-me24thiaz-baia-beta34meoph


172:bhs-25thiaz-bala-betambiph


173:phhs-25methiaz-bala-betadmph


174:bhs-oxadiaz-gly-zdapch


175:dhim-25thioph-gly-betadcph


176:bhs-me25oxaz-gly-zdap


177:ibhs-oxadiaz-gly-betahmo


178:ibhs-25thiaz-gly-betadcph


179:2py-35fur-gly-zdap


180:bhs-24thiaz-ala-beta13bendi


181:bhs-oxadiaz-gly-betadcph


182:phhs-oxadiaz-bala-betah35dc


183:ibhs-oxadiaz-bala-betaet




CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-31 -
184:phhs-nme35pyr-gly-betadmph


185:phhs-me24thioph-bala-betapy


186:tolhs-25oxaz-gly-beta34dcph


187:bim-26py-gly-betameph


188:ibhs-24thiaz-gly-betadcphee


189:phhs-25thiaz-gly-betacbph


190:tolhs-ithiadiaz-gly-betaphethioa


191:bhs-25methiaz-gly-betafu2


192:2pmhs-42nmeim-gly-betabenfu


193:bhs-25methiaz-gly-beta3quin


194:tolhs-25thiaz-bala-betahdcph


195:2py-24thioph-bala-betadcph


196:2py-42nmeim-ala-zdap


197:bim-35thioph-gly-betapy


198:bim-me25thioph-leu-zdap


199:bim-25methiaz-bala-betapy


200:tolhs-25thiaz-bala-betaoxaz


201:phhs-25oxaz-gly-betapbiph


202:tolhs-24thioph-bala-ibsdap


203:bhs-oxadiaz-gly-zdaptb


204:bim-42oxaz-leu-betapy


205.ibhs-25methiaz-gly-zdaptb


206:ibhs-25methiaz-gly-betaol


207:tolhs-ithiadiaz-gly-beta34dcph


208:phhs-ithiadiaz-gly-betacthioph


209:phhs-24thiaz-bala-betahmofu


210:phhs-ithiadiaz~ly-aspibua


211:phhs-24thiaz-gly-betathioph


212:bhs-25methiaz-gly-betaimid


213:gua-25thiaz-gly-betahdcph


214:bhs-25thiaz-ala-betacph


215:gua-24thiaz-gly-betaet


216:tolhs-25methiaz-bala-betahcbph


217:tolhs-ithiadiaz-gly-beta35dbph


218:ibhs-oxadiaz-gly-betadbph


219:tolhs-24thioph-gly-betathioph


220:bim-53pyrazo-bala-zdap




CA 02371604 2001-10-24
WO 00166618 PCTIEPOOJ03469
-32
221: bim-me24oxaz-gly-betadcph


222: bim-triaz-gly-psdap


223: phhs-25thiaz-bala-betampy


224: bhs-oxadiaz-gly-betadcphee


225: bim-ithiadiaz-leu-zdap


226: 2pmhs-24thiaz-gly-betafph


227: bhs-25thiaz-gly-betathioph


228: gua-24thiaz-bala-betadcph


229: impy-42nmeim-bala-betafph


10230: tolhs-24thioph-gly-betadmoph


231: ibhs-oxadiaz-bala-betapbiph


232: ibhs-25methiaz-bala-zdapee


233: tolhs-oxadiaz-gly-betafph


234: bhs-me24oxaz-bala-beta34meoph


15235: tolhs-25methiaz-bala-betahbcph


236: bim-42oxaz-leu-betadcph


237: tolhs-oxadiaz-gly-busu2be


238: tolhs-me25thiaz-ala-betapy


239: phhs-oxadiaz-bala-betainyl


20240: bhs-oxadiaz-gly-psdaptb


241: phhs-24thiaz-gly-busu2be


242: tolhs-25methiaz-bala-zdapee


243: bhs-25thiaz-nmgly-betahmph


244: bhs-oxadiaz-gly-betapy


25245: phhs-25oxaz-gly-betadcphee


246: phhs-24thiaz-gly-betapy


247: tolhs-ithiadiaz-bala-betamesu


248: bhs-25oxaz-nmgly-beta13bendi


249: phhs-24thiaz-gly-psdapch


30250: phhs-25oxaz-bala-asppha


251: phhs-25oxaz-bala-beta3quin


252: phhs-25methiaz-gly-beta3quin


253: phhs-me25oxaz-bala-betadcph


254: phhs-me24thiaz-ala-psdap


35255: ibhs-24thioph-gly-betapych


256: phhs-ithiadiaz-bala-betaibph


257: bhs-25oxaz-bala-betaftrif




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-33-
258:bhs-24thiaz-bala-betahc


259:2py-me24thioph-leu-psdap


260:phhs-24thioph-gly-betahc


261:dhim-26py-gly-betaheph


262:phhs-oxadiaz-bala-betaphethio


263:bhs-42nmeim-gly-betahni


264:tolhs-nme35pyr-bala-betahb


265:ibhs-nme35pyr-gly-betathiobe


266:tolhs-25oxaz-gly-betapytb


267:2py-me24oxaz-ala-beta34meoph


268:ibhs-ithiadiaz-gly-betahph


269:bhs-25methiaz-ala-beta13bendi


270:gua-26py-gly-beta3quin


271:phhs-ithiadiaz-gly-betathiobe


272:bhs-oxadiaz-gly-betabpy


273:ibhs-25thiaz-bala-psdapch


274:phhs-ithiadiaz-gly-betacph


275:phhs-24thioph-gly-betabthioph


276:gua-24thiaz-gly-betamesu


277:tolhs-24thiaz-gly-betambiph


278:bhs-me24oxaz-leu-betaph


279:2pmhs-25methiaz-gly-betabpy


280:bhs-ithiadiaz-bala-betathiobe


281:tolhs-25methiaz-bala-betafphe


282:tolhs-24thiaz-bala-betahni


283:ibhs-25thiaz-gly-zdap


284:bhs-25thiaz-ala-betaanaphth


285:ibhs-ithiadiaz-bala-betaphethio


286:ibhs-25oxaz-gly-betaheph


287:2py-me25thioph-leu-zdap


288:phhs-me24thiaz-bala-betaph


289:bim-me25thioph-bala-betapy


290:2py-25thiaz-bala-betapy


291:phhs-25thiaz-bala-betatbuph


292:bhs-24thioph-ala-beta13bendi


293:tolhs-25methiaz-bala-betathiobe


294:phhs-25thiaz-bala-beta13bendi




CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
-34-
295:bim-nme35pyr-leu-psdap


296:phhs-25methiaz-gly-betatos


297:tolhs-nme35pyr-bala-betaibph


298:phhs-25oxaz-bala-betadcphee


299:hs-24thioph-bala-betapy


300:bim-42nmeim-gly-psdap


301:ibhs-nme35pyr-bala-betambiph


302:bhs-nme35pyr-bala-betahdcph


303:tolhs-ithiadiaz-bala-beta34meoph


304:bhs-25methiaz-ala-betahph


305:bim-53pyrazo-bala-psdap


306:2pmhs-25thiaz-gly-betahb


307:2py-me24thiaz-leu-betadcph


308:gua-24thiaz-gly-betahmph


309:ibhs-nme35pyr-gly-betaimid


310:phhs-24thiaz-bala-zdaptb


311:tolhs-24thiaz-gly-betaph


312:gua-24thiaz-gly-betahdcph


313:bhs-25methiaz-bala-betapyee


314:2py-42nmeim-gly-csdap


315:bhs-25oxaz-ala-betadito


316:bhs-nme35pyr-gly-betafu3


317:ibhs-25oxaz-bala-betahdbph


318:phhs-nme35pyr-gly-betabmph


319:phhs-ithiadiaz-bala-betapych


320:bim-24thiaz-leu-psdap


321:bhs-oxadiaz-bala-betadcphee


322:tolhs-ithiadiaz-bala-betaol


323:gua-42pym-gly-betabediox


324:bim-24thiaz-gly-asppha


325:tolhs-24thiaz-gly-betahmofu


326:ibhs-oxadiaz-gly-beta23meoph


327:phhs-me24thioph-ala-zdap


328:phhs-me24oxaz-gly-betaph


329:bhs-25oxaz-nmgly-beta23meoph


330:tolhs-ithiadiaz-bala-betadbph


331:bhs-24im-bala-zdap




CA 02371604 2001-10-24
WO 00/66618 PCTlEP00103469
-35-
332:phhs-oxadiaz-gly-busu2be


333:ibhs-25methiaz-bala-betathio3


334:tolhs-24thiaz-bala-betabdimo


335:bhs-25oxaz-bala-betaipr


336:2py-me25thiaz-ala-betaph


337:bhs-25methiaz-gly-betapyr


338:tolhs-25oxaz-bala-betainyl


339:ibhs-25oxaz-gly-betaoxaz


340:tolhs-25thiaz-gly-betapyr


341:phhs-25methiaz-bala-betacbph


342:bhs-24thioph-gly-betadmoph


343:tolhs-oxadiaz-bala-aspbzla


344:dhim-25thioph-gly-zdap


345:phhs-25oxaz-bala-betafph


346:tolhs-25methiaz-bala-betaoxaz


347:ibhs-nme35pyr-bala-aspbzla


348:bhs-oxadiaz-bala-betahcbph


349:phhs-oxadiaz-gly-betameph


350:phhs-me24thioph-leu-betadcph


351:ibhs-nme35pyr-gly-busu2be


352:dhim-24oxaz-ala-zdap


353:2py-me24oxaz-ala-betaph


354:phhs-ithiadiaz-gly-betampy


355:bhs-ithiadiaz-gly-psdap


356:ibhs-24thioph-gly-aspbzla


357:bim-ithiadiaz-leu-psdap


358:dhim-24thiaz-gly-betahdcph


359:bim-me25oxaz-ala-betadcph


360:gua-24thiaz-gly-betaoxope


361:bim-nme35pyr-ala-betadcph


362:phhs-24thioph-bala-betabthioph


363:2py-25methiaz-bala-aspbzla


364:tolhs-nme35pyr-gly-betaet


365:bhs-52thiaz-gly-zdap


366:ibhs-oxadiaz-gly-betafbph


367:bhs-24thiaz-gly-betafu3


368:bim-25thiaz-gly-betapy




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-36-
369: bhs-24thiaz-gly-betah35dc


370: tolhs-24thiaz-bala-aspibua


371: tolhs-24thioph-bala-betadhbfu


372: tolhs-24thioph-gly-psdapee


373: ibhs-25thiaz-bala-betapym


374: bhs-52thiaz-ala-betainyl


375: ibhs-25oxaz-bala-betadtrif


376: ibhs-ithiadiaz-gly-betamethioph


377: tolhs-25methiaz-gly-betabpy


10378: ibhs-25methiaz-bala-beta35dbph


379: ibhs-25oxaz-bala-beta35dbph


380: bhs-me25thiaz-bala-zdap


381: bhs-25oxaz-gly-asppha


382: bhs-25methiaz-bala-betaphethio


15383: bim-42oxaz-bala-betadcph


384: ibhs-24thiaz-bala-beta3quin


385: bhs-25methiaz-gly-betadcphtb


386: bhs-ithiadiaz-gly-betadcphtb


387: ibhs-25oxaz-bala-betafph


20388: tolhs-24thioph-gly-betahmo


389: bhs-24thioph-bala-betafbph


390: phhs-24thiaz-bala-beta13bendi


391: 2py-24oxaz-bala-zdap


392: phhs-nme35pyr-gly-betadbph


25393: bhs-25methiaz-bala-betacph


394: tolhs-25oxaz-gly-betamethioph


395: ibhs-24thiaz-bala-betambiph


396: bhs-24thioph-nmgly-ibsdap


397: phhs-nme35pyr-bala-betahmph


30398: dhim-52thiaz-ala-betameph


399: tolhs-oxadiaz-gly-beta3quin


400: bhs-25methiaz-nmgly-betaoxaz


401: bhs-oxadiaz-ala-betafphe


402: phhs-25methiaz-gly-betafluo


35403: bhs-25oxaz-leu-betadcph


404: tolhs-25methiaz-gly-betaipr


405: dhim-26py-gly-betahcbph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-37
406:bhs-25methiaz-gly-zdapee


407:2pmhs-24thioph-gly-betahbcph


408:phhs-ithiadiaz-bala-betahc


409:tolhs-24thiaz-gly-betaipr


410:ibhs-nme35pyr-bala-betainyl


411:bhs-42pym-ala-zdap


412:bhs-25oxaz-bala-betaphethio


413:impy-25thiaz-gly-betahmofu


414:bhs-25thiaz-bala-betadmph


415:tolhs-me25thioph-ala-betaph


416:bim-24thioph-gly-aspbzla


417:tolhs-nme35pyr-gly-betaheph


418:phhs-25oxaz-bala-betatrif


419:tolhs-24thioph-gly-betathiome


420:ibhs-nme35pyr-gly-betathioph


421:ibhs-25methiaz-gly-betambiph


422:bhs-25oxaz-bala-betacthioph


423:ibhs-24thiaz-gly-csdap


424:2py-ithiadiaz-gly-asppha


425:tolhs-25thiaz-gly-betabdimo


426:tolhs-25thiaz-gly-zdap


427:tolhs-25methiaz-bala-betadmoph


428:tolhs-25thiaz-gly-betabediox


429:phhs-25methiaz-gly-betadbph


430:ibhs-oxadiaz-gly-betahni


431:tolhs-24thiaz-bala-betahdbph


432:phhs-25oxaz-gly-betadmoph


433:phhs-24thiaz-gly-betaomebendi


434:tolhs-ithiadiaz-bala-zdapee


435:tolhs-25oxaz-gly-betathiobe


436:phhs-25oxaz-bala-betaibph


437:2py-25oxaz-leu-zdap


438:bhs-24oxaz-leu-betadcph


439:bhs-nme35pyr-ala-psdap


440:phhs-oxadiaz-bala-betabediox


441:tolhs-oxadiaz-bala-betapbiph


442:2py-ithiadiaz-bala-aspaba




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-38
443:tolhs-24thiaz-bala-psdaptb


444:bhs-24thiaz-gly-busu2be


445:ibhs-25thiaz-gly-betaoxaz


446:bhs-24thioph-gly-betaphethio


447:bim-35thioph-bala-betapy


448:dimethpym-25methiaz-gly-betameph


449:2py-ithiadiaz-bala-zdap


450:bhs-25thiaz-nmgly-betabpy


451:2py-35fur-ala-betapy


452:phhs-25oxaz-gly-betamethioph


453:tolhs-me24thioph-bala-betapy


454:tolhs-ithiadiaz-gly-betafu3


455:gua-26py-gly-betaimid


456:phhs-nme35pyr-bala-betaphethio


457:bhs-25oxaz-gly-aspibua


458:ibhs-oxadiaz-gly-betafph


459:ibhs-oxadiaz-gly-betafu3


460:ibhs-24thiaz-bala-betahcbph


461:tolhs-24thioph-gly-betafluo


462:2py-24thioph-leu-betapy


463:impy-25oxaz-gly-ibsdap


464:phhs-nme35pyr-gly-aspbzla


465:4pmhs-42nmeim-bala-betadcph


466:tolhs-me25thioph-leu-beta34meoph


467:phhs-oxadiaz-gly-betaoxaz


468:tolhs-nme35pyr-gly-betamethioph


469:bhs-25thiaz-gly-betaheph


470:phhs-nme35pyr-bala-betaoxaz


471:bhs-24thioph-nmgly-betacph


472:bim-me25oxaz-ala-beta34meoph


473:bhs-25methiaz-gly-betacbph


474:impy-25methiaz-gly-betahmofu


475:dhim-35pyrazo-gly-betameph


476:bim-35fur-ala-zdap


477:phhs-25oxaz-gly-betahc


478:bhs-24thioph-bala-aspibua


479:2py-24thiaz-gly-betacthioph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-39
480: bhs-oxadiaz-bala-suabu


481: bhs-25methiaz-gly-aspaba


482: tolhs-nme35pyr-gly-betaipr


483: 2py-ithiadiaz-ala-psdap


484: ibhs-ithiadiaz-bala-betathiobe


485: bhs-nme35pyr-bala-betapyee


486: tolhs-25methiaz-bala-betahc


487: tolhs-25oxaz-gly-zdaptb


488: bhs-24thioph-gly-beta23meoph


10489: tolhs-24thioph-bala-betaphethioa


490: bhs-nme35pyr-bala-betahbcph


491: phhs-25oxaz-gly-betadbph


492: bhs-25methiaz-bala-asppha


493: ibhs-nme35pyr-gly-psdapch


15494: bhs-oxadiaz-bala-ibsdap


495: bhs-25methiaz-bala-betapy


496: ibhs-24thiaz-gly-betabdimo


497: ibhs-24thiaz-bala-beta34dcph


498: phhs-oxadiaz-gly-betadcphch


20499: bim-nme35pyr-gly-betadcph


500: bhs-ithiadiaz-gly-betahc


501: ibhs-ithiadiaz-bala-betathiome


502: bim-me24oxaz-leu-zdap


503: bhs-25oxaz-gly-betadcphee


25504: bim-25fur-leu-psdap


505: tolhs-oxadiaz-bala-betatbuph


506: gua-42pym-gly-betadbph


507: ibhs-24thioph-gly-aspaba


508: ibhs-25methiaz-gly-beta34dcph


30509: tolhs-ithiadiaz-bala-betahbcph


510: bhs-oxadiaz-nmgly-betaoxaz


511: tolhs-25thiaz-bala-betadbph


512: bhs-oxadiaz-bala-betaomebendi


513: thpym-24thiaz-gly-betameph


35514: bhs-ithiadiaz-bala-beta35dbph


515: 2pmhs-25thiaz-gly-betadtrif


516: ibhs-ithiadiaz-bala-psdapch




CA 02371604 2001-10-24
WO 00!6661$ PCTlEP00l03469
- 40 -
517: phhs-24thioph-bala-betaanaphth


518: bhs-25thiaz-bala-betaet


519: ibhs-ithiadiaz-bala-betahdcph


520: bhs-42oxaz-ala-zdap


521: tolhs-24thioph-gly-busu2be


522: bhs-ithiadiaz-gly-betaftrif


523: tolhs-nme35pyr-gly-betadhbfu


524: bhs-24thiaz-gly-aspibua


525: bhs-24thioph-gly-betapy


10526: ibhs-25oxaz-gly-aspbzla


527: tolhs-24thioph-bala-betadbph


528: phhs-25methiaz-gly-betabenfu


529: bhs-nme35pyr-ala-betadito


530: phhs-me25thiaz-ala-beta34meoph


15531: ibhs-25methiaz-bala-betamethi


532: ibhs-25oxaz-gly-betahmofu


533: bhs-24thioph-gly-zdapch


534: phhs-24thioph-bala-betah35dc


535: ibhs-24thioph-bala-betahcbph


20536: ibhs-ithiadiaz-bala-betahph


537: bhs-ithiadiaz-bala-asppha


538: dhim-25thioph-gly-betameph


539: tolhs-ithiadiaz-gly-betadcphee


540: phhs-oxadiaz-bala-betatbuph


25541: bhs-25thiaz-gly-betamethi


542: bhs-ithiadiaz-gly-betahbcph


543: tolhs-25oxaz-bala-betadcphtb


544: phhs-24thiaz-gly-betadhbfu


545: ibhs-25oxaz-gly-psdap


30546: ibhs-25methiaz-bala-betatrif


547: bhs-ithiadiaz-bala-beta23meoph


548: phhs-25thiaz-gly-betahmofu


549: bhs-24thioph-gly-betamethi


550: ibhs-25oxaz-gly-betadito


35551: bhs-25methiaz-gly-betadcph


552: bhs-me24thioph-ala-psdap


553: tolhs-25thiaz-gly-betahni




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-41 -
554:ibhs-24thioph-gly-betafu3


555:phhs-24thiaz-gly-betahni


556:2py-24thioph-gly-aspbzla


557:ibhs-nme35pyr-gly-betaibph


558:tolhs-25methiaz-gly-psdapch


559:bhs-ithiadiaz-gly-betaet


560:bhs-nme35pyr-ala-beta34meoph


561:phhs-oxadiaz-gly-betapyr


562:ibhs-25oxaz-gly-zdapch


563:bhs-24oxaz-ala-betainyl


564:ibhs-nme35pyr-gty-betahmo


565:bhs-25thiaz-nmgly-beta34dcph


566:bhs-nme35pyr-bala-betaomebendi


567:tolhs-25oxaz-gly-betaph


568:bhs-24thiaz-nmgly-betahph


569:bhs-nme35pyr-leu-psdap


570:ibhs-24thioph-gly-betahni


571:ibhs-25oxaz-gly-betaftrif


572:phhs-me24thiaz-leu-zdap


573:ibhs-24thiaz-gly-betathiobe


574:phhs-25oxaz-bala-betabediox


575:phhs-ithiadiaz-gly-betameph


576:tolhs-ithiadiaz-gly-psdaptb


577:2py-me25oxaz-leu-zdap


578:dhim-24oxaz-gly-zdap


579:tolhs-oxadiaz-gly-betapbiph


580:tolhs-24thioph-gly-betadcphch


581:bhs-ithiadiaz-bala-psdapee


582:imhs-25methiaz-gly-zdap


583:bhs-25oxaz-gly-betabnaphth


584:bhs-24thiaz-gly-betaftrif


585:phhs-25methiaz-gly-betahmofu


586:phhs-ithiadiaz-bala-betamethi


587:bhs-ithiadiaz-gly-betabdimo


588:dhim-42pym-gly-betainyl


589:bhs-25thioph-bala-betadcph


590:2py-thiadiaz-leu-betapy




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-42
591:tolhs-25oxaz-bala-betabmph


592:phhs-25oxaz-gly-betadito


593:bim-ithiadiaz-gly-psdap


594:phhs-24thioph-gly-betaibph


595:tolhs-25oxaz-gly-psdapee


596:ibhs-25methiaz-gly-betamesu


597:bhs-oxadiaz-bala-aspaba


598:bhs-oxadiaz-bala-betapym


599:phhs-24thioph-gly-betafu3


600:tolhs-24thioph-gly-betaphethioa


601:ibhs-25oxaz-bala-betafphe


602:tolhs-25oxaz-gly-betacbph


603:ibhs-25methiaz-bala-betaipro


604:bhs-nme35pyr-gly-betaipro


605:tolhs-24thioph-bala-betahmph


606:tolhs-25methiaz-bala-betadbph


607:bhs-25methiaz-gly-betaamibe


608:impy-24thiaz-gly-betabediox


609:ibhs-oxadiaz-gly-betapym


610:2py-25methiaz-ala-betapy


611:tolhs-nme35pyr-bala-betabnaphth


612:phhs-24thioph-gly-beta4bph


613:ibhs-ithiadiaz-bala-betah35dc


614:bhs-oxadiaz-gly-betaomebendi


615:tolhs-25methiaz-gly-betafph


616:phhs-25oxaz-bala-betadcphtb


617:ibhs-ithiadiaz-gly-beta35dbph


618:2py-25oxaz-bala-betadhbfu


619:bhs-25oxaz-gly-betatrif


620:ibhs-25thiaz-gly-zdapch


621:bhs-oxadiaz-gly-betadmoph


622:phhs-nme35pyr-bala-betacthioph


623:phhs-25thiaz-bala-betavxaz


624:bim-me25oxaz-gly-psdap


625:bhs-25methiaz-ala-betapy


626:ibhs-24thioph-bala-betathioph


627:phhs-25methiaz-gly-suabu




CA 02371604 2001-10-24
WO 00/66618 PCTIEP00I034fi9
-43-
628:phhs-ithiadiaz-bala-betacph


629:phhs-25methiaz-gly-betadmoph


630:phhs-ithiadiaz-bala-zdapch


631:phhs-24thiaz-gly-betabediox


632:bhs-nme35pyr-bala-betatos


633:tolhs-25oxaz-bala-betaipr


634;bhs-24thioph-gly-betapytb


635:bhs-25methiaz-leu-betapy


636:4pmhs-24thiaz-gly-betapy


637:tolhs-oxadiaz-bala-betapytb


638:tolhs-oxadiaz-gly-beta34meoph


639:bhs-25oxaz-bala-betatbuph


640:ibhs-25oxaz-gly-suabu


641:phhs-25methiaz-gly-psdaptb


642:tolhs-25oxaz-bala-betahph


643:ibhs-nnme35pyr-gly-betabmph


644:bhs-25oxaz-gly-betadmph


645:ibhs-25oxaz-bala-betabpy


646:phhs-me24thioph-gly-betadcph


647:tolhs-24thioph-bala-betathio3


648:ibhs-25methiaz-bala-psdap


649:bim-25thiaz-gly-psdap


650:ibhs-25methiaz-gly-betahbcph


651:ibhs-ithiadiaz-gly-betacbph


652:ibhs-25methiaz-gly-betabthioph


653:bim-me24thioph-gly-betadcph


654:bhs-oxadiaz-bala-betatos


655:phhs-nme35pyr-gly-betabdimo


656:gua-26py-gly-betahmofu


657:ibhs-24thioph-gly-psdaptb


658:phhs-25oxaz-bala-betainyl


659:phhs-24thiaz-bala-betameph


660:bim-25thioph-bala-zdap


661:tolhs-25oxaz-bala-betahmo


662:tolhs-ithiadiaz-gly-betacbph


663:tolhs-25methiaz-bala-beta34meoph


664:bhs-24im-gly-betameph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-44-
665:tolhs-oxadiaz-gly-betadcphee


666:phhs-25thiaz-gly-betadmph


667:bhs-nme35pyr-ala-betadmoph


668:ibhs-24thiaz-gly-betafphe


669:circa-25oxaz-gly-betameph


670:phhs-25oxaz-gly-betatos


671:phhs-25methiaz-bala-beta3quin


672:bim-24oxaz-ala-zdap


673:ibhs-25methiaz-gly-csdap


674:phhs-ithiadiaz-bala-betafph


675:dhim-52thiaz-gly-psdap


676:bhs-24thiaz-ala-zdap


677;ibhs-ithiadiaz-bala-aspibua


678:ibhs-oxadiaz-bala-betahmofu


679:phhs-24thioph-bala-betaoxaz


680:phhs-25oxaz-bala-busu2be


681:tolhs-25oxaz-bala-ibsdap


682:ibhs-24thioph-gly-betacph


683:bhs-35thioph-ala-betameph


684:2py-25thioph-gly-betainyl


685:bim-nme35pyr-ala-betapy


686:2py-25thiaz-bala-aspaba


687:bhs-24thioph-gly-betabenfu


688:phhs-nme35pyr-bala-betabph


689:ibhs-oxadiaz-gly-betatos


690:phhs-ithiadiaz-gly-betamesu


691:2pmhs-25oxaz-bala-betabnaphth


692:tolhs-25methiaz-bala-busu2be


693:tolhs-25oxaz-gly-betapyr


694:bhs-ithiadiaz-gly-beta34meoph


695:phhs-24thioph-bala-betampy


696:tolhs-nme35pyr-gly-busu2be


697:bhs-25oxaz-gly-psdap


698:phhs-25oxaz-gly-betaph


699:phhs-me25oxaz-gly-zdap


700:bhs-24thioph-gly-betahc


701:ibhs-25thiaz-gly-beta23meoph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-45
702:phhs-25methiaz-gly-betabnaphth


703:phhs-24thioph-gly-betabpy


704:tolhs-25oxaz-bala-betatbuph


705:bhs-24thiaz-gly-zdaptb


706:gua-26py-gly-betaph


707:tolhs-me25thiaz-bala-betadcph


708:phhs-24thiaz-bala-betabediox


709:ibhs-25methiaz-gly-betathiobe


710:phhs-24thiaz-gly-beta3quin


711:tolhs-25oxaz-gly-betadmph


712:dhpyrr-25thioph-gly-betadcph


713:phhs-ithiadiaz-gly-betahb


714:hts-42nmeim-gly-zdap


715:dhim-24thiaz-gly-zdap


716:bhs-24thioph-ser-betapy


717:2py-25fur-bala-betadcph


718:bhs-4.2nmeim-bala-betaol


719:bhs-25methiaz-bala-betafphe


720:ibhs-25thiaz-bala-betaipr


721:2py-24thiaz-bala-aspaba


722:phhs-me25thiaz-ala-betadcph


723:phhs-oxadiaz-bala-betadmph


724:tolhs-ithiadiaz-bala-betapych


725:phhs-25oxaz-bala-betapych


726:tolhs-24thiaz-bala-betadbph


727:ibhs-25methiaz-gly-betabenfu


728:bhs-25methiaz-gly-beta4bph


729:bhs-ithiadiaz-gly-betameph


730:phhs-24thioph-bala-betabenfu


731:bhs-25methiaz-nmgly-ibsdap


732:bhs-oxadiaz-gly-betacbph


733:bhs-nme35pyr-gly-betaftrif


734:phhs-25oxaz-gly-suabu


735:bhs-25methiaz-nmgly-betaanaphth


736:bhs-ithiadiaz-bala-betadbph


737:bim-me25oxaz-gly-betaph


738:phhs-24thioph-gly-betaoxaz




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-46
739: bhs-42oxaz-gly-zdap


740: bhs-24thiaz-nmgly-betahmph


741: ibhs-ithiadiaz-bala-betapytb


742: bhs-25methiaz-nmgly-betafphe


743: bhs-oxadiaz-ala-beta34meoph


744: bim-53pyrazo-ala-zdap


745: phhs-25methiaz-gly-betadcph


746: phhs-24thioph-gly-zdaptb


747: hts-25oxaz-bala-betadcph


10748: 2py-ithiadiaz-ala-betadcph


749: bim-nme35pyr-gly-betapy


750: phhs-oxadiaz-gly-betatrif


751: ibhs-24thiaz-bala-betabnaphth


752: 2py-25methiaz-gly-beta3quin


15753: phhs-oxadiaz-bala-betapbiph


754: tolhs-25thiaz-gly-betatrif


755: bim-53pyrazo-gly-betapy


756: bhs-ithiadiaz-nmgly-betabnaphth


757: phhs-25thiaz-gly-betadtrif


20758: phhs-nme35pyr-gly-psdapch


759: tolhs-25thiaz-bala-betaomebendi


760: phhs-24thiaz-gly-betaoxope


761: ibhs-oxadiaz-gly-betathio3


762: phhs-oxadiaz-gly-betaph


25763: phhs-oxadiaz-bala-betabph


764: bim-me25thiaz-bala-betaph


765: ibhs-oxadiaz-bala-beta4bph


766: bim-me25thiaz-leu-zdap


767: 2py-25methiaz-ala-psdap


30768: bhs-42oxaz-ala-betadcph


769: bhs-25methiaz-gly-betainyl


770: bim-triaz-gly-betadcph


771: tolhs-24thiaz-bala-betabthioph


772: bhs-nme35pyr-bala-busu2be


35773: bhs-25oxaz-nmgly-betainyl


774: phhs-me25thiaz-gly-betapy


775: bhs-ithiadiaz-gly-beta4bph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-47
776: phhs-me25thiaz-bala-betadcph


777: bhs-25thiaz-gly-zdap


778: phhs-24thiaz-bala-betah35dc


779: tolhs-nme35pyr-bala-betahmofu


780: bhs-24thiaz-bala-betabdimo


781: bim-ithiadiaz-gly-zdap


782: ibhs-24thioph-gly-betadbph


783: bhs-me25oxaz-g1y-betapy


784: bhs-24thiaz-ala-beta23meoph


10785: ibhs-nme35pyr-bala-betapytb


786: bhs-25oxaz-gly-betaamibe


787: bhs-ithiadiaz-gly-betaoxope


788: gua-25thioph-gly-betacthioph


789: bhs-oxadiaz-gly-betapyr


15790: phhs-me25oxaz-ala-beta34meoph


791: bhs-ithiadiaz-gly-betadrnph


792: bim-25methiaz-bala-betaimid


793: ibhs-oxadiaz-bala-betameph


794: ibhs-oxadiaz-bala-betahph


20795: phhs-24thioph-gly-betathio3


796: tolhs-nme35pyr-bala-betapyr


797: ibhs-ithiadiaz-gly-betamethi


798: phhs-24thiaz-bala-beta3quin


799: ibhs-nme35pyr-gly-betaipro


25800: ibhs-oxadiaz-gly-aspbzla


801: bhs-25thiaz-bala-betamesu


802: bim-35fur-bala-zdap


803: tolhs-nme35pyr-gly-betabph


804: phhs-ithiadiaz-bala-betaphethioa


30805: ibhs-nme35pyr-gly-ibsdap


806: bim-24thiaz-feu-betapy


807: thpy-25methiaz-gly-betadcph


808: phhs-24thioph-gly-betabenfu


809: ibhs-25methiaz-gly-betapych


35810: ibhs-oxadiaz-gly-betaph


811: bhs-25thiaz-gly-betaftrif


812: phhs-nme35pyr-bala-betapym




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-48
813:tolhs-25thiaz-gly-betameph


814:2py-25methiaz-bala-betaheph


815:2py-25methiaz-gly-aspaba


816:phhs-24thiaz-bala-betapych


817:bhs-35fur-bala-betadcph


818:phhs-ithiadiaz~ly-suabu


819:2py-42pym-gly-zdap


820:ibhs-ithiadiaz-gly-betaimid


821:tolhs-25oxaz-gly-betahdbph


822:ibhs-25oxaz-bala-betahbcph


823:ibhs-ithiadiaz-bala-betaoxope


824:tolhs-oxadiaz-gly-ibsdap


825:tolhs-nme35pyr-bala-betabenfu


826:bhs-24thioph-gly-betaphethioa


827:bhs-me25thiaz-bala-betadcph


828:tolhs-me24oxaz-bala-betaph


829:phhs-ithiadiaz-bala-betafbph


830:ibhs-24thioph-gly-betabediox


831:tolhs-me25thioph-bala-zdap


832:tolhs-oxadiaz-bala-betapym


833:bhs-25oxaz-gly-zdaptb


834:ibhs-ithiadiaz-bala-beta13bendi


835:bhs-nme35pyr-bala-betatbuph


836:phhs-oxadiaz-gly-betaphethioa


837:dhim-thiadiaz-gly-betameph


838:bhs-24thioph-nmgly-betacthioph


839:phhs-25methiaz-bala-betaoxaz


840:ibhs-24thiaz-gly-betaimid


841:phhs-24thioph-bala-betabnaphth


842:bhs-24im-bala-betapy


843:toihs-24thiaz-gly-betabph


844:2py-25meth iaz-g ly-aspbzla


845:2pmhs-25thiaz-phe-zdap


846:2pm hs-24th iaz-g
ly-betahb


847:bhs-24thiaz-gly-betambiph


848:phhs-25oxaz-gly-psdapch


849:ibhs-24thiaz-gly-beta4bph




CA 02371604 2001-10-24
WO 00/66618 PCT/EP00103469
-49-
850: bim-ithiadiaz-bala-betadcph


851: tolhs-25thiaz-gly-betahdcph


852: bhs-ithiadiaz-bala-betamethioph


853: ibhs-25oxaz-gly-ibsdap


854: ibhs-25oxaz-gly-betabthioph


855: bhs-25methiaz-leu-psdap


856: bhs-25thiaz-bala-betabph


857: tolhs-nme35pyr-bala-betaanaphth


858: bim-me24thioph-leu-betaph


859: thpy-42pym-gly-betadcph


860: thpy-25oxaz-bala-zdap


861: ibhs-ithiadiaz-bala-betahmofu


862: ibhs-oxadiaz-gly-betabph


863: bhs-24thiaz-bala-beta13bendi


864: dhim-24oxaz-ala-betainyl


865: tolhs-nme35pyr-gly-betaoxaz


866: tolhs-oxadiaz-gly-betathio3


867: bhs-25fur-gly-zdap


868: bim-24im-ala-psdap


869: ibhs-nme35pyr-bala-betabmph


870: bhs-ithiadiaz-ala-betathio3


871: tolhs-25thiaz-gly-beta34meoph


872: tolhs-24thioph-gly-betahmofu


873: phhs-25oxaz-gly-zdap


874: 2pmhs-42nmeim-bala-betabph


875: tolhs-25oxaz-bala-busu2be


876: phhs-ithiadiaz-gly-betathioph


877: bhs-25fur-ala-psdap


878: tolhs-25methiaz-bala-betaphethio


879: phhs-oxadiaz-bala-betathiobe


880: ibhs-24thioph-gly-betaibph


881: tolhs-25thiaz-gly-betadito


882: tolhs-25thiaz-gly-betahc


883: tolhs-24thiaz-bala-betabenfu


884: 2py-25thiaz-bala-aspibua


885: impy-25thiaz-gly-betaipr


886: phhs-ithiadiaz-bala-beta35dbph




CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-50-
887: phhs-25thiaz-bala-suabu


888: phhs-24thiaz-bala-betapym


889: dhim-52thiaz-gly-zdap


890: ibhs-24thioph-bala-betathiome


891: bim-42nmeim-bala-betadcph


892: tolhs-ithiadiaz-gly-betaoxaz


893: phhs-25thiaz-bala-betamethi


894: phhs-24thiaz-gly-betaphethioa


895: bhs-ithiadiaz-ala-betacthioph


896: phhs-nme35pyr-bala-betahbcph


897: phhs-me24thiaz-bala-betadcph


898: hs-25oxaz-gly-betadcph


899: ibhs-25oxaz-gly-beta3quin


900: tolhs-24thioph-bala-betaibph


901: tolhs-24thioph-bala-betahb


902: thazep-24thiaz-gly-betapy


903: ibhs-nme35pyr-bala-beta3quin


904: tolhs-25oxaz-bala-betaamibe


905: bhs-oxadiaz-ala-zdap


906: tolhs-24thioph-bala-beta4bph


907: phhs-ithiadiaz-bala-betapbiph


908: gua-42pym-gly-betafph


909: phhs-nme35pyr-gly-betatbuph


910: tolhs-nme35pyr-bala-beta34dcph


911: phhs-24thiaz-bala-aspibua


912: 2py-25thioph-ala-betameph


913: bim-me25thioph-leu-beta34meoph


914: 2py-me25oxaz-leu-betapy


915: 2py-24thioph-gly-aspibua


916: ibhs-25oxaz-gly-betadcphtb


917: gua-42pym-gly-betadcph


918: bhs-24thiaz-bala-betadcphee


919: tolhs-25oxaz-bala-psdapee


920: tolhs-oxadiaz-bala-betaftrif


921: ibhs-oxadiaz-gly-betatbuph


922: bhs-me24oxaz-ala-betadcph


923: tolhs-ithiadiaz-bala-betafu3




CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-51
924:ibhs-24thioph-bala-zdaptb


925:phhs-25thiaz-bala-betadbph


926:2py-42oxaz-leu-zdap


927:bhs-oxadiaz-bala-betahmofu


928:ibhs-25methiaz-gly-betathiome


929:phhs-nme35pyr-bala-betadito


930:phhs-24thioph-gly-beta34meoph


931:tolhs-nme35pyr-bala-betainyl


932:phhs-me24thioph-gly-beta34meoph


933:bim-me25thiaz-gly-betadcph


934:bhs-24thiaz-ala-csdap


935:phhs-24thioph-gly-aspbzla


936:bim-25thiaz-gly-betatrif


937:impy-24thioph-gly-betacbph


938:dhpyrr-25methiaz-gly-betapy


939:bhs-24thiaz-bala-betadmoph


94~:bhs-42pym-gly-psdap


941:phhs-ithiadiaz-bala-betapyee


942:phhs-24thioph-bala-betathiobe


943:bim-35thioph-leu-psdap


944:phhs-me24oxaz-leu-betapy


945:phhs-24thioph-bala-betacph


946:ibhs-25methiaz-bala-betatos


947:tolhs-25oxaz-bala-betaoxope


948:gua-24oxaz-gly-betamethioph


949:tolhs-25methiaz-gly-suabu


95Q:phhs-24thiaz-bala-betamethi


951:phhs-ithiadiaz-gly-betadhbfu


952:gua-24thiaz-gly-betadbph


953:bhs-25methiaz-nmgly-betabnaphth


954:bhs-24thioph-leu-betapy


955:phhs-25thiaz-gly-betacthioph


956:bim-25oxaz-bala-aspaba


957:phhs-ithiadiaz-bala-psdapee


958:tolhs-oxadiaz-bala-busu2be


959:phhs-me24thiaz-bala-betapy


960:phhs-me24thioph-leu-beta34meoph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-52-
961:phhs-24thioph-gly-betapbiph


962:bhs-ithiadiaz-bala-beta34dcph


963:bim-me24thiaz-ala-betaph


964:bhs-nme35pyr-bala-psdapch


965:phhs-24thiaz-bala-betabmph


966:phhs-24thiaz-gly-betadmph


967:bim-triaz-ala-zdap


968:thpym-25oxaz-gly-betameph


969:bim-24thiaz-gly-betaibph


970:tolhs-24thiaz-gly-betaheph


971:tolhs-ithiadiaz-gly-zdaptb
'


972:bim-26pyrazi-gly-zdap


973:ibhs-24thioph-gly-betaol


974:bim-me25thiaz-gly-betaph


975:ibhs-25methiaz-bala-betadcphch


976:phhs-24thioph-gly-psdapch


977:phhs-24thioph-gly-betahdbph


978:phhs-me25oxaz-gly-betapy


979:dhim-24thiaz-gly-betadcph


980:bim-me24thiaz-ala-betadcph


981:bhs-nme35pyr-gly-betaomebendi


982:phhs-oxadiaz-bala-psdapee


983:bhs-24thioph-bala-betahc


984:ibhs-24thiaz-bala-betathiobe


985:bhs-25methiaz-gly-beta13bendi


986:phhs-oxadiaz-bala-busu2be


987:phhs-ithiadiaz-gly-betafu3


988:phhs-24thioph-gly-betaimid


989:tolhs-25thiaz-bala-beta35dbph


990:bhs-oxadiaz-gly-betacthioph


991:bhs-ithiadiaz-gly-betapych


992:bim-24oxaz-gly-psdap


993:tolhs-me24thiaz-bala-betapy


994:bhs-25oxaz-gly-betathio3


995:bim-oxadiaz-bala-betadcph


996:phhs-nme35pyr-gly-betafu3


997:dhim-25thiaz-ala-betapy




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-53-
998: agua-25methiaz-gly-psdap


999: bim-nme35pyr-leu-zdap


1000:tolhs-24thiaz-bala-betahmo


1001:bim-35fur-bala-psdap


1002:bhs-24thiaz-gly-betadmoph


1003:dhim-25methiaz-gly-betapy


1004:phhs-25methiaz-gly-betapytb


1005:2py-me25oxaz-leu-beta34meoph


1006:gua-24thiaz-gly-betapym


101007:bim-35fur-leu-zdap


1008:bhs-25thioph-leu-betadcph


1009:ibhs-25thiaz-bala-betameph


1010:bhs-24thioph-gly-psdap


1011:2py-35fur-gly-psdap


151012:ibhs-oxadiaz-bala-busu2be


1013:ibhs-oxadiaz-bala-zdap


1014:bhs-25methiaz-gly-betahb


1015:tolhs-25oxaz-bala-beta4bph


1016:phhs-me24oxaz-bala-beta34meoph


201017:tolhs-25oxaz-gly-beta4bph


1018:bim-35thioph-gly-betadcph


1019:bhs-25oxaz-bala-beta3quin


1020:impy-25thiaz-gly-betabediox


1021:bhs-nme35pyr bala-betabmph


251022:phhs-me24oxaz-gly-beta34meoph


1023:tolhs-24thioph-bala-betaipr


1024:2py-me25thioph-leu-betadcph


1025:ibhs-24thiaz-bala-betaol


1026:ibhs-24thioph-gly-betatos


301027:phhs-25thiaz-gly-betahni


1028:tolhs-24thioph-bala-betamethi


1029:tolhs-24thiaz-gly-betafu2


1030:ibhs-ithiadiaz-gly-betathioph


1031:2py-42nmeim-ala-betadcph


351032:phhs-24thioph-bala-aspibua


1033:2py-25thiaz-gly-zdap


1034:bhs-25thiaz-gly-psdapch




CA 02371604 2001-10-24
WO 00166618 PCTlEP00l03469
-54-
1035:gua-42pym-gly-betadito


1036:ibhs-25oxaz-gly-betahdcph


1037:tolhs-oxadiaz-bala-betathiome


1038:phhs-25thiaz-bala-betaftrif


1039:phhs-ithiadiaz-bala-betabdimo


1040:bhs-nme35pyr-ala-beta13bendi


1041:ibhs-25methiaz-gly-betadtrif


1042:dhim-25thiaz-gly-betainyl


1043:bim-24thiaz-bala-betapy


1044:bhs-25thiaz-nmgly-betathioph


1045:bhs-25thiaz-gly-betatbuph


1046:tolhs-ithiadiaz-gly-aspibua


1047:phhs-ithiadiaz-bala-ibsdap


1048:bhs-24thiaz-bala-zdaptb


1049:ibhs-25methiaz-gly-busu2be


1050:tolhs-oxadiaz-bala-betahmph


1051:phhs-ithiadiaz-gly-csdap


1052:impy-24thioph-bala-psdap


1053:bim-me25thiaz-leu-psdap


1054:phhs-ithiadiaz-gly-ibsdap


1055:bhs-25methiaz-gly-betah35dc


1056:bhs-25thiaz-met-betameph


1057:tolhs-25methiaz-bala-betainyl


1058:phhs-25thiaz-gly-beta23meoph


1059:phhs-24thioph-gly-betafu2


1060:phhs-me24oxaz-gly-betadcph


1061:tolhs-25thiaz-bala-betah35dc


1062:bhs-24thioph-bala-psdapch


1063:bhs-me24thioph-gly-beta34meoph


1064:tolhs-me24thiaz-ala-betaph


1065:phhs-25methiaz-bala-betaibph


1066:ibhs-ithiadiaz-gly-betadcph


1067:phhs-24thiaz-gly-aspbzla


1068:tolhs-25methiaz-bala-betabdimo


1069:bhs-24thioph-ala-betadmph


1070:gua-42pym-gly-betahcbph


1071:ibhs-25oxaz-bala-betamesu




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-55-
1072:ibhs-25thiaz-bala-betahcbph


1073:bhs-24thiaz-gly-betabediox


1074:bhs-24thiaz-ala-betamesu


1075:gua-42pym-gly-betaet


1076:bhs-oxadiaz-bala-betathiome


1077:ibhs-25thiaz-gly-betahb


1078:tolhs-ithiadiaz-bala-betadcphtb


1079:bhs-24thiaz-bala-betaoxaz


1080:bhs-24thioph-gly-zdap


1081:bim-nme35pyr-bala-betapy


1082:ibhs-ithiadiaz-gly-beta23meoph


1083:bhs-25thiaz-ala-beta34meoph


1084:tolhs-me25thioph-bala-betadcph


1085:bhs-ithiadiaz-bafa-betaol


1086:phhs-24thiaz-gly-betacbph


1087:phhs-25methiaz-bala-betabenfu


1088:bim-nme35pyr-leu-betapy


1089:2py-35fur-leu-zdap


1090:ibhs-24thioph-gly-betabpy


1091:tolhs-25thiaz-bala-betathiome


1092:phhs-24thioph-bala-busu2be


1093:tolhs-oxadiaz-gly-betaphethio


1094:dhim-26py-ala-betathioph


1095:phhs-nme35pyr-gly-beta34dcph


1096:ibhs-25oxaz-bala-beta23meoph


1097:bhs-25thiaz-ala-zdap


1098:dhthi-24thiaz-bala-betadcph


1099:bhs-nme35pyr-bala-betaoxaz


1100:ibhs-25methiaz-bala-betapytb


1101:ibhs-nme35pyr-gly-betapytb


1102:tolhs-24thiaz-bala-betamesu


1103:bhs-24thioph-gly-betafu3


1104:tolhs-oxadiaz-gly-betabenfu


1105:tolhs-nme35pyr-gly-betafbph


1106:bim-ithiadiaz-bala-zdap


1107:gua-25thioph-gly-suabu


1108:bhs-oxadiaz-gly-betathiobe




CA 02371604 2001-10-24
WO 00/66618 PCTIEP00I03469
-56
1109:phhs-25oxaz-gly-betafluo


1110:2py-me25oxaz-leu-psdap


1111:ibhs-25oxaz-bala-betahni


1112:ibhs-oxadiaz-gly-betaol


1113:tolhs-25thiaz-gly-betaftrif


1114:tolhs-25oxaz-bala-betabdimo


1115:tolhs-25oxaz-gly-asppha


1116:bhs-me24thiaz-ala-betaph


1117:tolhs-24thiaz-gly-betafbph


1118:2py-oxad iaz-g ly-psdap


1119:bhs-25thiaz-bala-betahb


1120:bim-35fur-leu-psdap


1121:bhs-ithiadiaz-nmgiy-ibsdap


1122:bhs-24oxaz-ala-betameph


1123:bhs-nme35pyr-bala-betapyr


1124:bhs-nme35pyr-ala-betapy


1125:tolhs-24thioph-gly-betaftrif


1126:phhs-25oxaz-gly-betaphethioa


1127:tolhs-nme35pyr-gly-csdap


1128:2py-25fur-bala-zdap


1129:2py-24oxaz-leu-psdap


1130:tolhs-24thiaz-bala-zdapch


1131:phhs-oxadiaz-gly-betaoxope


1132:ibhs-24thiaz-bala-betapym


1133:thpym-24thiaz-gly-beta35dbph


1134:phhs-ithiadiaz-bala-betadmph


1135:phhs-me25thiaz-leu-betaph


1136:phhs-nme35pyr-bala-betadcphch


1137:2py-me24thiaz-bala-betaph


1138:phhs-me24thioph-ala-betapy


1139:ibhs-25thiaz-bala-csdap


1140:tolhs-oxadiaz-bala-betaamibe


1141:ibhs-nme35pyr-gly-betabenfu


1142:bhs-25thiaz-gly-betainyl


1143:bhs-25thiaz-gly-betahdcph


1144:phhs-25thiaz-gly-betacph


1145:phhs-oxadiaz-gly-betafph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-57-
1146:phhs-25oxaz-gly-betapym


1147:tolhs-24thiaz-bala-betacph


1148:2py-me24thioph-ala-betaph


1149:ibhs-24thiaz-bala-betaipro


1150:hyd-25thiaz-bala-betameph


1151:bim-52thiaz-ala-betapy


1152:bim-me25thiaz-ala-beta34meoph


1153:bhs-oxadiaz-bala-betabmph


1154:dhim-24thiaz-ala-psdap


1155:ibhs-24thioph-bala-zdapee


1156:gua-25thiaz-gly-betahbcph


1157:bhs-ithiadiaz-bala-betabthioph


1158:tolhs-24thiaz-bala-beta13bendi


1159:bim-me24oxaz-ala-beta34meoph


1160:bim-me25oxaz-gly-betapy


1161:2py-25methiaz-gly-aspibua


1162:bim-25thiaz-leu-betapy


1163:bhs-25thiaz-gly-betah35dc


1164:tolhs-25thiaz-bala-betafbph


1165:bhs-24thioph-bala-csdap


1166:dhim-25thiaz-gly-betahdcph


1167:bhs-25oxaz-nmgly-betacthioph


1168:tolhs-24thiaz-gly-betadcphtb


1169:2py-25methiaz-bala-psdap


1170:bim-ithiadiaz-gly-betadcph


1171:bim-25fur-gly-psdap


1172:tolhs-ithiadiaz-gly-psdapch


1173:bhs-53pyrazo-gly-betadcph


1174:ibhs-oxadiaz-bala-betahb


1175:bhs-nme35pyr-gly-betaanaphth


1176.phhs-25thiaz-bala-psdapch


1177:tolhs-oxadiaz-bala-betahmo


1178:tolhs-25methiaz-bala-betathio3


1179:bim-25oxaz-ala-psdap


1180:bim-42nmeim-gly-betapy


1181:ibhs-nme35pyr-bala-betah35dc


1182:tolhs-24thioph-gly-betabthioph




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-58-
1183: tolhs-25methiaz-bala-betadito


1184: thpym-25thiaz-bala-psdap


1185: bhs-25oxaz-gly-zdap


1186: bhs-25thiaz-phe-betameph


1187: bhs-25methiaz~ly-betathiobe


1188: bhs-nme35pyr-bala-betameph


1189: phhs-ithiadiaz-gly-betaoxope


1190: tolhs-24thiaz-gly-betabpy


1191: phhs-ithiadiaz-bala-psdap


1192:bgua-42nmeim-gly-betadcph


1193: dhim-24oxaz-gly-betamyl


1194: impy-25oxaz-gly-betampy


1195: bhs-25methiaz-bala-betadmoph


1196: gua-24thiaz-gly-betadito


1197:ibhs-ithiadiaz-gly-busu2be


1198: bhs-oxadiaz-bala-betadito


1199: ibhs-24thiaz-bala-betaphethioa


1200: ibhs-ithiadiaz-bala-betatrif


1201: bhs-24thioph-ala-psdap


1202:ibhs-nme35pyr-bala-betahdbph


1203: bhs-24thioph-bala-psdap


1204: 2py-25thiaz-gly-betatbuph


1205: ibhs-24thioph-bala-beta3quin


1206: ibhs-ithiadiaz-bala-betaoxaz


1207:bhs-me24oxaz-gly-zdap


1208: gua-24thiaz-gly-betah35dc


1209: ibhs-24thioph-gly-betatrif


1210: tolhs-25methiaz-gly-betambiph


1211: thpym-26py-gly-betadcph


1212:phhs-24thioph-bala-betahmph


1213: ibhs-25methiaz-bala-betadmph


1214: tolhs-24thioph-gly-betafphe


1215; tolhs-25oxaz-bala-betabnaphth


1216: bhs-24thioph-gly-betaoxope


1217:pahs-26py-gly-betapy


1218: 2py-24im-gly-betadcph


1219: tolhs-nme35pyr-bala-betapytb




CA 02371604 2001-10-24
W0 00166618 PCTIEP00I03469
-59
1220: phhs-nme35pyr-gly-betapyee


1221: bhs-25thiaz-bala-betabmph


1222: gua-42pym-gly-betadmoph


1223: ibhs-nme35pyr-bala-betathiome


1224: ibhs-25methiaz-gly-betainyl


1225: bhs-24thiaz-gly-betahcbph


1226: ibhs-24thiaz-bala-psdap


1227: bhs-triaz-ala-zdap


1228. dhim-24thiaz-ala-betameph


1229:ibhs-24thiaz-bala-betapych


1230: ibhs-25methiaz-gly-betaoxope


1231: tolhs-24thiaz-bala-betahbcph


1232: tolhs-24thioph-giy-betathio3


1233: tolhs-oxadiaz-gly-betapych


1234:tolhs-24thiaz-bala-betatbuph


1235: 2py-25oxaz-leu-betadcph


1236: ibhs-24thiaz-gly-betadito


1237: tolhs-25thiaz-bala-betacthioph


1238: phhs-24thiaz-bala-betaimid


1239:ibhs-25methiaz-gly-betabnaphth


1240: dhim-24oxaz-ala-betameph


1241: phhs-oxadiaz-gly-beta34meoph


1242: 2py-oxadiaz-bala-asppha


1243: phhs-nme35pyr-gly-aspibua


1244:ibhs-nme35pyr-gly-beta13bendi


1245: bhs-oxadiaz-gly-betahb


1246: tolhs-24thioph-gly-beta4bph


1247: ibhs-25oxaz-bala-betah35dc


1248: ibhs-25thiaz-gly-betaoxope


1249:thpym-25thioph-gly-betahcbph


1250: tolhs-25oxaz-bala-betahmofu


1251: bhs-42pym-ala-psdap


1252: bhs-24thiaz-nmgly-betaipro


1253: ibhs-nme35pyr-gly-betahmofu


1254:phhs-ithiadiaz-gly-betapym


1255: ibhs-24thioph-bala-betahbcph


1256: tolhs-oxadiaz-bala-betadcphch




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-60
1257:phhs-24thioph-bala-betabmph


1258:phhs-25oxaz-bala-betaftrif


1259:2py-thiadiaz-ala-betadcph


1260:phhs-me25thiaz-leu-psdap


1261:phhs-nme35pyr-gly-betapych


1262:bhs-oxadiaz-bala-betafu3


1263:2pmhs-42nmeim-bala-betameph


1264:ibhs-oxadiaz-bala-betabmph


1265:ibhs-25thiaz-bala-beta23meoph


1266:gua-25thiaz-giy-betaph


1267:bhs-24thiaz-ser-betapy


1268:bhs-24thiaz-met-betadcph


1269:bhs-ithiadiaz-gly-betacthioph


1270:bhs-42pym-gly-betainyl


1271:2py-triaz-bala-zdap


1272:2py-me24oxaz-ala-zdap


1273:phhs-24thioph-bala-betahc


1274:tolhs-24thioph-bala-psdapch


1275:phhs-oxadiaz-gly-betainyl


1276:bhs-25thiaz-nmgly-betamesu


1277:ibhs-24thioph-bala-beta34dcph


1278:phhs-nme35pyr-bala-betameph


1279:phhs-24thioph-bala-betaamibe


1280:2py-oxadiaz-leu-psdap


1281;bim-25thiaz-ala-betadcph


1282:bim-35thioph-gly-zdap


1283:bim-35py-gly-zdap


1284:ibhs-25oxaz-bala-betapyee


1285:tolhs-me24thiaz-bala-zdap


1286:tolhs-25thiaz-bala-betadito


1287:phhs-oxadiaz-gly-betadtrif


1288:bhs-24thioph-gly-betathiobe


1289:bhs-25thiaz-gly-betaphethioa


1290:tolhs-25oxaz-gly-betahc


1291:bhs-25oxaz-gly-betaimid


1292:tolhs-oxadiaz-bala-betaipr


1293:phhs-24thiaz-gly-betapyr




CA 02371604 2001-10-24
WO 00/66618 PCTIEPOOl03469
-61
1294:bhs-me25thioph-gly-betadcph


1295:phhs-nme35pyr-bala-betadmoph


1296:phhs-24thioph-bala-betabpy


1297:phhs-24thioph-bala-beta23meoph


1298:phhs-24thiaz-bala-zdapch


1299:bhs-42oxaz-bala-zdap


1300:ibhs-ithiadiaz-bala-betadcphee


1301;phhs-nme35pyr-bala-betambiph


1302:bim-42nmeim-bala-betacbph


1303:tolhs-25thiaz-bala-beta34dcph


1304:hs-25methiaz-bala-betapy


1305:dhim-4.2pym-gly-betapy


1306:bhs-42oxaz-leu-betapy


1307:bhs-24thiaz-nmgly-betadmph


1308:dhim-25thiaz-ala-psdap


1309:phhs-25oxaz-bala-betamethi


1310:phhs-me24thiaz-ala-betaph


1311:ibhs-24thioph-gly-betameph


1312:gua-24oxaz-gly-betaheph


1313:bhs-ithiadiaz-gly-betal3bendi


1314:bhs-ithiadiaz-bala-betahcbph


1315:bhs-nme35pyr-gly-betaheph


1316:bhs-25thiaz-1eu-psdap


1317:tolhs-25oxaz-bala-betadmoph


1318:bim-25thiophme-gly-zdap


1319:bhs-nme35pyr-nmgly-betabnaphth


1320:2py-24thioph-bala-betahni


1321:phhs-oxadiaz-bala-psdapch


1322:ibhs-25thiaz-bala-betabediox


1323:tolhs-25oxaz-gly-betafphe


1324:ibhs-25methiaz-bala-beta4bph


1325:tolhs-25thiaz-gly-betadbph


1326:dhim-26py-gly-zdap


1327:ibhs-24thioph-gly-betacthioph


1328:2py-ithiadiaz-gly-psdap


1329:tolhs-me25oxaz-ala-betaph


1330:ibhs-nme35pyr-gly-betamethioph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-62
1331:bhs-ithiadiaz-bala-betabpy


1332:bhs-oxadiaz-bala-betabph


1333:ibhs-oxadiaz-gly-betampy


1334:dhthi-26py-gly-betapy


1335:bhs-25thiaz-gly-betadmph


1336:bim-25methiaz-gly-betaomebendi


1337:tolhs-25thiaz-bala-betadhbfu


1338:bhs-oxadiaz-nmgly-beta34meoph


1339:bim-nme35pyr-bala-asppha


1340:2py-42nmeim-gly-betafphe


1341:bhs-35thioph-gly-psdap


1342:2py-42nmeim-bala-betaanaphth


1343:phhs-25thiaz-gly-psdapch


1344:bhs-25methiaz-bala-betabdimo


1345:tolhs-me24oxaz-gly-betaph


1346:ibhs-24thioph-bala-betadito


1347:bhs-24thioph-nmgly-betabnaphth


1348:bhs-oxadiaz-bala-betadcphtb


1349:bhs-26py-ala-psdap


1350:bhs-24thioph-nmgly-betamesu


1351:tolhs-oxadiaz-bala-betaimid


1352:bhs-ithiadiaz-nmgly-betadito


1353:phhs-25methiaz-bala-zdapee


1354:bhs-ithiadiaz-bala-betaphethioa


1355:impy-24thioph-gly-betambiph


1356:bhs-ithiadiaz-gly-betafu2


1357:bhs-ithiadiaz-nmgly-betathioph


1358:phhs-25oxaz-bala-suabu


1359:bhs-25methiaz-bala-betacbph


1360:phhs-me24oxaz-bala-betadcph


1361:dhim-25thiaz-gly-betadtrif


1362:bhs-24thioph-bala-betathiome


1363:phhs-25oxaz-gly-beta34dcph


1364:tolhs-me25oxaz-bala-betadcph


1365:ibhs-25thiaz-gly-betaamibe


1366:bhs-nme35pyr-nmgly-beta23meoph


1367:2py-24thiaz-gly-aspaba




CA 02371604 2001-10-24
WO 00166fi18 PCTIEP00103469
-63-
1368:gua-24thioph-bala-betadcph


1369:tolhs-24thioph-gly-betamethioph


1370:gua-24thiaz-gly-betaph


1371:2py-25methiaz-bala-aspibua


1372:ibhs-25oxaz-gly-zdaptb


1373:phhs-me25thiaz-leu-betadcph


1374:bhs-nme35pyr-bala-psdaptb


1375:bhs-25methiaz-gly-betahcbph


1376:ibhs-25methiaz-gly-betah35dc


1377:bhs-24thiaz-bala-aspaba


1378:tolhs-ithiadiaz-bala-beta13bendi


1379:bhs-ithiadiaz-bala-betaph


1380:tolhs-oxadiaz-gly-betaoxope


1381:2py-thiadiaz-gly-betapy


1382:phhs-24thiaz-bala-betaphethioa


1383:gua-24thiaz-gly-beta35dbph


1384:bim-26py-gly-betainyl


1385:pahs-25thiaz-bala-betameph


1386:bim-thiadiaz-ala-psdap


1387:bhs-me24thiaz-leu-beta34meoph


1388:phhs-25oxaz-gly-betambiph


1389:phhs-oxadiaz-gly-betaomebendi


1390:phhs-25oxaz-bala-betamethioph


1391:dhim-24thiaz-gly-betapy


1392:bim-24thioph-nmala-betadcph


1393:bhs-nme35pyr-gly-betampy


1394:2py-me24oxaz-ba la-betapy


1395:2py-25thioph-gly-zdap


1396:ibhs-24thioph-bala-betah35dc


1397:phhs-me25thioph-gly-betadcph


1398:bhs-24thioph-bala-betapym


1399:tolhs-24thioph-gly-aspbzla


1400:ibhs-25thiaz-bala-betapyee


1401:tolhs-nme35pyr-gly-betapyee


1402:bhs-25oxaz-gly-betahdcph


1403:bhs-25oxaz-gly-beta4bph


1404:ibhs-24thiaz-bala-beta4bph




CA 02371604 2001-10-24
WO 00166fi18 PCTlEP001034fi9
-64-
1405:bim-ithiadiaz-bala-betapy


1406:ibhs-nme35pyr-bala-betabdimo


1407:2py-25thiaz-gly-aspibua


1408:bhs-25oxaz-ala-betabpy


1409:bhs-oxadiaz-gly-betahbcph


1410:bim-me25thioph-leu-betaph


1411:bhs-24thiaz-bala-betadito


1412:dhim-24oxaz-gly-betadcph


1413:tolhs-ithiadiaz-gly-betahcbph


1414:bhs-nme35pyr-leu-betapy


1415:tolhs-nme35pyr-bala-betaol


1416:ibhs-oxadiaz-gly-betapych


1417:tolhs-nme35pyr-gly-betacthioph


1418:tolhs-nme35pyr-bala-aspbzla


1419:2py-me24thioph-gly-beta34meoph


1420:dhpyrr-24thiaz-gly-betadcph


1421:bhs-24thiaz-gly-betaet


1422:bim-24thiaz-nmala-betadcph


1423:ibhs-nme35pyr-gly-betambiph


1424:tolhs-ithiadiaz-gly-ibsdap


1425:tolhs-25oxaz-gly-betacthioph


1426:tolhs-24thioph-gly-betadhbfu


1427:bhs-me25thiaz-ala-betaph


1428:phhs-25thiaz-bala-betameph


1429:bhs-24thiaz-ala-beta34dcph


1430:ibhs-nme35pyr-bala-betapyr


1431:2py-me24thioph-leu-betapy


1432:bhs-24thiaz-bala-betafu2


1433:bhs-ithiadiaz-bala-betaamibe


1434:bhs-25methiaz-ala-betadmoph


1435:bim-me24thiaz-gly-zdap


1436:bim-25methiaz-bala-csdap


1437:2py-me25oxaz-ala-beta34meoph


1438;phhs-oxadiaz-gly-ibsdap


1439:phhs-25thiaz-bala-betabph


1440:bhs-25methiaz-ala-beta34dcph


1441:tolhs-oxadiaz-bala-betapyee




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-65-
1442:ibhs-oxadiaz-bala-betaanaphth


1443:tolhs-25oxaz-bala-betathiobe


1444:2pmhs-24thiaz-bala-beta4bph


1445:ibhs-ithiadiaz-gly-ibsdap


1446:phhs-24thioph-bala-aspaba


1447:tolhs-24thiaz-bala-betaamibe


1448:bhs-25methiaz-gly-betaanaphth


1449:bhs-24thioph-gly-betaph


1450:bhs-oxadiaz-bala-betahb


1451:bhs-52thiaz-gly-betapy


1452:ibhs-oxadiaz-bala-betafluo


1453:phhs-nrne35pyr-bala-betadtrif


1454:phhs-25oxaz-bala-betapyr


1455:bhs-25methiaz-bala-betaipr


1456:ibhs-24thiaz-gly-beta35dbph


1457:ibhs-25thiaz-gly-psdapch


1458:bhs-24thiaz-bala-betatbuph


1459:tolhs-ithiadiaz-bala-betadmoph


1460:ibhs-25thiaz-gly-betaftrif


1461:bhs-25methiaz-ala-betafphe


1462:sabhs-42pym-gly-betapy


1463:phhs-me25thiaz-bala-zdap


1464:phhs-24thiaz-gly-betaibph


1465:2py-25methiaz-gly-betacthioph


1466:dhim-25thioph-gly-betapy


1467:bim-me24thiaz-bala-psdap


1468:ibhs-24thioph-gly-betabnaphth


1469:tolhs-25methiaz-bala-betaoxope


1470:sabhs-25oxaz-bala-betameph


1471:tolhs-25methiaz-gly-beta34dcph


1472:ibhs-oxadiaz-bala-betathiome


1473:dhim-42pym-gly-betahdcph


1474:2py-25thiaz-leu-betapy


1475:ibhs-25thiaz-gly-betah35dc


1476:bhs-25oxaz-bala-betathiobe


1477:bhs-oxadiaz-nmgly-betamesu


1478:bhs-oxadiaz-bala-betaol




CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-66-
1479:phhs-oxadiaz-gly-aspbzla


1480:hs-25thiaz-gly-betapy


1481:tolhs-ithiadiaz-bala-betaomebendi


1482:tolhs-25methiaz-bala-beta4bph


1483:phhs-ithiadiaz-bala-csdap


1484:bim-25py-gly-zdap


1485:ibhs-24thioph-gly-betafbph


1486:impy-25methiaz-gly-betambiph


1487:2pmhs-25thiaz-bala-betamethioph


1488:tolhs-24thioph-bala-betafluo


1489:ibhs-ithiadiaz-gly-aspaba


1490;phhs-25methiaz-bala-betacph


1491:bhs-nme35pyr-gly-betatos


1492:dimethpym-25thiaz-gly-betadcph


1493:ibhs-oxadiaz-bala-betaimid


1494:tolhs-24thioph-bala-betaoxope


1495:bhs-nme35pyr-bala-betamethioph


1496:2py-me24thiaz-leu-betaph


1497:tolhs-nme35pyr-bala-betahni


1498:phhs~xadiaz-gly-betacthioph


1499:bhs-25thiaz-gly-busu2be


1500:ibhs-oxadiaz-bala-betaipro


1501:tolhs-25thiaz-bala-betadmoph


1502:bhs-25methiaz-ala-betainyl


1503:bhs-25oxaz-bala-betahcbph


1504:ibhs-ithiadiaz-gly-betacthioph


1505:tolhs-nme35pyr-bala-betaomebendi


1506:phhs-24thioph-bala-betaipr


1507;tolhs-25methiaz-gly-betaoxaz


1508:tolhs-nme35pyr-bala-betaamibe


1509:bhs-25thiaz-bala-betaheph


1510:ibhs-24thioph-gly-asppha


1511:phhs-oxadiaz-bala-betadmoph


1512:2py-25thiaz-ala-betameph


1513:bhs-thiadiaz-ala-zdap


1514:bhs-24thiaz-bala-betafph


1515:2pmhs-25thiaz-bala-betabmph




CA 02371604 2001-10-24
WO 00166618 PCTlEPOOI03469
-67-
1516:bhs-24thioph-bala-betafu2


1517:bim-me25thioph-bala-zdap


1518:bhs-25methiaz-gly-aspibua


1519:bhs-nme35pyr-nmgly-beta34dcph


1520:gua-24thiaz-gly-betafu2


1521:phhs-oxadiaz-gly-betambiph


1522:bhs-24thioph-bala-aspaba


1523:phhs-24thiaz-gly-beta35dbph


1524:ibhs-24thioph-gly-betaipro


1525:bhs-ithiadiaz-bala-psdapch


1526:bhs-25oxaz-gly-betamethioph


1527:bhs-25thiaz-ala-beta34dcph


1528:bhs-ithiadiaz-bala-betaipro


1529:bhs-25oxaz-gly-betah35dc


1530:gua-25thioph-gly-betah35dc


1531:bhs-25oxaz-gly-betabph


1532:bhs-oxadiaz-bala-betaphethio


1533:impy-24thiaz-bala-psdap


1534:bhs-25methiaz-gly-betaol


1535:phhs-25oxaz-bala-betapytb


1536:tolhs-25oxaz-bala-zdaptb


1537:tolhs-nme35pyr-bala-betadcphee


1538:bgua-25thioph-gly-betameph


1539:bhs-oxadiaz-gly-betathio3


1540:ibhs-25thiaz-gly-betahc


1541:gua-24thiaz-gly-betathioph


1542:2py-53pyrazo-bala-betapy


1543:phhs-ithiadiaz-gly-beta34dcph


1544:dhim-25thioph-ala-betadcph


1545:phhs-25thiaz-gly-betapy


1546:ibhs-25thiaz-bala-betah35dc


1547:phhs-25methiaz-gly-psdap


1548:bhs-oxadiaz-gly-betafluo


1549:impy-25thiaz-gly-betacbph


1550:2py-24im-bala-zdap


1551:tolhs-oxadiaz-bala-betahb


1552:phhs-25oxaz-bala-betaoxope




CA 02371604 2001-10-24
WO OOI66618 PCTlEP00103469
-68
1553:tolhs-25thiaz-gly-betaipr


1554:ibhs-oxadiaz-bala-csdap


1555:ibhs-24thiaz-gly-betampy


1556:bim-thiadiaz-gly-betadcph


1557:2py-me24thioph-bala-betadcph


1558:bhs-ithiadiaz-nmgly-betadhbfu


1559:phhs-25oxaz-bala-betathioph


1560:ibhs-25oxaz-bala-betaol


1561:bhs-nme35pyr-gly-betaoxope


101562:phhs-ithiadiaz-bala-betathiobe


1563:2py-25methiaz-leu-zdap


1564:tolhs-25thiaz-gly-betafu2


1565:phhs-24thioph-bala-betahni


1566;ibhs-nme35pyr-gly-betatbuph


151567:ibhs-ithiadiaz-gly-betapbiph


1568:tolhs-oxadiaz-gly-betatos


1569:bim-triaz-bala-betapy


1570:tolhs-25oxaz-bala-betafphe


1571:bhs-ithiadiaz-nmgly-betathio3


201572:2py-me25thioph-gly-zdap


1573:tolhs-25oxaz-gly-csdap


1574:2py-thiadiaz-gly-psdap


1575:bhs-52thiaz-gly-betainyl


1576:phhs-ithiadiaz-gly-betahmo


251577:ibhs-25thiaz-gly-betathiome


1578:2py-oxadiaz-bala-betapy


1579:2pmhs-24thiaz-bala-betathioph


1580:bim-25thiaz-bala-betahc


1581;bim-triaz-leu-psdap


301582:phhs-25methiaz-bala-aspibua


1583:bhs-me24thioph-bala-beta34meoph


1584:phhs-25oxaz-gly-betadcphtb


1585:tolhs-ithiadiaz-gly-beta4bph


1586:ibhs-25oxaz-bala-betamethioph


351587:phhs-ithiadiaz-gly-betah35dc


1588;bhs-25methiaz-gly-betahdbph


1589:gua-25thiaz-gly-betahdbph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-69-
1590:4pmhs-24thiaz-bala-betameph


1591:bhs-ithiadiaz-gly-betainyl


1592:tolhs-25oxaz-bala-betah35dc


1593:2py-25fur-bala-psdap


1594:nmhs-24thiaz-gly-psdap


1595:phhs-25methiaz-bala-betadcphee


1596:ibhs-25methiaz-bala-betabph


1597:ibhs-oxadiaz-bala-betabph


1598:ibhs-ithiadiaz-bala-betahbcph


1599:2py-triaz-ala-zdap


1600:bhs-nme35pyr-nmgly-beta3quin


1601:dhim-25thioph-ala-zdap


1602:bhs-me24oxaz-leu-beta34meoph


1603:phhs-25methiaz-gly-aspaba


1604:bhs-nme35pyr-bala-betadtrif


1605:tolhs-24thioph-bala-betadtrif


1606:bhs-25methiaz-bala-betahb


1607:2py-24thiaz-ala-betainyl


1608:bhs-25thiaz-gly-betaph


1609:tolhs-oxadiaz-bala-betabediox


1610:bhs-oxadiaz-bala-betaoxope


1611:bhs-25thiaz-nmgly-betaanaphth


1612:phhs-24thioph-gly-betadmph


1613:phhs-25methiaz-gly-betainyl


1614:gua-24thiaz-gly-betadcph


1615:bhs-24thioph-bala-betadcphee


1616:phhs-ithiadiaz-gly-betabph


1617:bhs-thiadiaz-ala-betapy


1618:bim-me25oxaz-leu-psdap


1619:2py-me24thioph-bala-betaph


1620:tolhs-nme35pyr-bala-betabediox


1621:bhs-25methiaz-ala-beta34meoph


1622:tolhs-ithiadiaz-gly-betadmoph


1623:bhs-24thiaz-nmala-betapy


1624:2py-triaz-leu-betadcph


1625:ibhs-24thioph-bala-betaibph


1626:phhs-me25oxaz-ala-betaph




CA 02371604 2001-10-24
WO OOI66618 PCTIEP00I03469
-70
1627:gua-24oxaz-gly-betaph


1628:phhs-ithiadiaz-gly-betapych


1629:bhs-me24oxaz-leu-zdap


1630:ibhs-25thiaz-bala-betamethi


1631:bim-42oxaz-leu-psdap


1632:bhs-25thiaz-hphe-betameph


1633:bhs-nme35pyr-nmgly-betabpy


1634:2pmhs-25thiaz-bala-beta13bendi


1635:ibhs-ithiadiaz-gly-zdapch


1636:tolhs-oxadiaz~ly-psdapee


1637:bhs-25oxaz-ala-betainyl


1638:tolhs-25thiaz-bala-suabu


1639:bim-24thiaz-leu-betadcph


1640:bhs-24thioph-gly-beta34dcph


1641:tolhs-oxadiaz-gly-aspaba


1642:phhs-25thiaz-gly-betathiome


1643:phhs-24thioph-bala-psdaptb


1644:phhs-nme35pyr-bala-betabediox


1645:tolhs-oxadiaz-gly-betahcbph


1646:bhs-ithiadiaz-bala-betaomebendi


1647:phhs-24thioph-bala-betahph


1648:2py-me25thioph-ala-psdap


1649:2py-24thiaz-leu-betapy


1650:2py-25oxaz-gly-aspibua


1651:sabhs-24thiaz-gly-betapy


1652:phhs-25oxaz-gly-betahbcph


1653:tolhs-25methiaz-bala-betabph


1654:bhs-ithiadiaz-bala-aspibua


1655:dhim-26py-gly-betaoxaz


1656:ibhs-oxadiaz-gly-beta4bph


1657:bhs-24thiaz-nmgly-beta3quin


1658:phhs-25methiaz-gly-betabph


1659:tolhs-25methiaz-gly-betathiobe


1660:bhs-25thiaz-bala-zdapee


1661:bim-24thiaz-bala-zdap


1662:2pmhs-42nmeim-ser-psdap


1663:phhs-24thiaz-gly-betathio3




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-71
1664:bhs-24thioph-nmgly-beta13bendi


1665:phhs-25methiaz-gly-betaheph


1666:tolhs-25thiaz-gly-betaet


1667:tolhs-me24thioph-ala-betadcph


1668:ibhs-25oxaz-bala-betaipr


1669:phhs-me25thioph-ala-zdap


1670:ibhs-25thiaz-bala-betambiph


1671:tolhs-me25thioph-ala-beta34meoph


1672:ibhs-25thiaz-gly-betaphethio


1673:phhs-24thiaz-bala-betaomebendi


1674:ibhs-24thiaz-gly-beta34meoph


1675:bim-35fu~-bala-betapy


1676:tolhs-25thiaz-gly-zdapee


1677:ibhs-25oxaz-gly-betatrif


1678:phhs-oxadiaz-gly-betamethioph


1679:2py-thiadiaz-bafa-zdap


1680:bhs-24thioph-bala-zdapch


1681:bhs-25methiaz-bala-betafu2


1682:ibhs-oxadiaz-gly-psdap


1683:bhs-oxadiaz-gly-betapyee


1684:bhs-me24thioph-gly-zdap


1685:bim-me25oxaz-ala-zdap


1686:bhs-25methiaz-gly-betaomebendi


1687:tolhs-25thiaz-bala-betahb


1688:2py-24thioph-bala-beta34dcph


1689:ibhs-oxadiaz-bala-betapych


1690:ibhs-24thioph-gly-betafu2


1691:bhs-25oxaz-ala-beta3quin


1692:bhs-24thioph-bala-betabediox


1693:phhs-nme35pyr-gly-betapy


1694:ibhs-ithiadiaz-gly-betamesu


1695:bhs-25methiaz-gly-betabediox


1696:phhs-25thiaz-gly-betafu2


1697:2py-24thiaz-bala-betaheph


1698:phhs-oxadiaz-gly-asppha


1699:ibhs-ithiadiaz-bala-psdap


1700:thpym-25methiaz-bala-psdap




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-72-
1701:tolhs-25oxaz-bala-betabenfu


1702:ibhs-ithiadiaz-gly-betathio3


1703:bhs-25methiaz-gly-betampy


1704:bim-52thiaz-gly-betameph


1705:tolhs-nme35pyr-gly-beta23meoph


1706:bhs-ithiadiaz-bala-betaftrif


1707:bhs-25oxaz-gly-betadmoph


1708:phhs-24thiaz-gly-betainyl


1709:ibhs-25thiaz-gly-betaanaphth


1710:phhs-ithiadiaz-bala-betaphethio


1711:phhs-25thiaz-bala-betahdcph


1712:4pmhs-25oxaz-gly-betapy


1713:bhs-53pyrazo-ala-betapy


1714:phhs-nme35pyr-bala-betathioph


1715:bhs-nme35pyr-nmgly-betamesu


1716:phhs-25oxaz~ly-betampy


1717:2py-25oxaz-ba la-betapheth
ioa


1718:bhs-25methiaz-bala-betafu3


1719:phhs-me24oxaz-leu-betadcph


1720:bhs-25thiaz-ala-ibsdap


1721:bhs-ithiadiaz-gly-betabmph


1722:bhs-ithiadiaz-bala-betadmoph


1723:phhs-25thiaz-gly-betatbuph


1724:2py-42pym-ala-psdap


1725:ibhs-nme35pyr-gly-betaoxaz


1726:phhs-24thioph-bala-betafu3


1727:phhs-25oxaz-bala-betapbiph


1728:2py-me25oxaz-ala-betapy


1729:phhs-me24thiaz-gly-betaph


1730:bhs-25methiaz-nmgly-betaipro


1731:phhs-me24thiaz-leu-psdap


1732:gua-42pym-gly-betaphethio


1733:bhs-24thioph-gly-betaoxaz


1734:bhs-oxadiaz-bala-betahc


1735:ibhs-nme35pyr-gly-betainyl


1736:tolhs-nme35pyr-bala-psdaptb


1737:bhs-oxadiaz-bala-betadmph




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-73
1738:phhs-ithiadiaz-gly-betafbph


1739:phhs-25thiaz-gly-betahcbph


1740:tolhs-25oxaz-bala-betaibph


1741:tolhs-25oxaz-gly-betapych


1742:bhs-24thiaz-nmgly-betabnaphth


1743:phhs-25methiaz-gly-zdap


1744:2py-42nmeim-gly-betaipro


1745:bhs-24thioph-bala-betafph


1746:ibhs-24thioph-bala-betambiph


1747:2pmhs-42nmeim-gly-betahdcph


1748:2py-24thiaz-gly-zdap


1749:phhs-oxadiaz-bala-betamethi


1750:bhs-me25thiaz-bala-betaph


1751:bhs-triaz-ala-betadcph


1752:bhs-25methiaz-bala-betahmofu


1753:bhs-25thiaz-ala-betafphe


1754:phhs-oxadiaz-bala-betafluo


1755:phhs-24thiaz-bala-betabenfu


1756:2py-24thiaz-bala-aspbzla


1757:bhs-24thiaz-ala-psdap


1758:phhs-oxadiaz-gly-betapyee


1759:tolhs-25thiaz-bala-betaph


1760:ibhs-24thioph-bala-betaheph


1761:tolhs-24thioph-bala-zdaptb


1762:tolhs-24thiaz-gly-zdapee


1763:ibhs-ithiadiaz-bala-betaomebendi


1764:phhs-ithiadiaz-bala-betamethioph


1765:phhs-nme35pyr-bala-betathiobe


1766:phhs-25thiaz-bala-betafphe


1767:ibhs-25thiaz-bala-beta34dcph


1768:phhs-24thiaz-gly-psdaptb


1769:tolhs-24thioph-gly-betatos


1770:gua-26py-gly-betamethi


1771:bhs-oxadiaz-gly-betahmofu


1772:impy-4.2nmeim-gly-betahph


1773:bhs-24thiaz-bala-betadcphtb


1774:tolhs-ithiadiaz-gly-busu2be




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-74
1775:bim-me24oxaz-bala-beta34meoph


1776.tolhs-25methiaz-gly-betafu3


1777:tolhs-25oxaz-bala-aspbzla


1778:bhs-oxadiaz-ala-betacph


1779:phhs-ithiadiaz-bala-aspbzla


1780:ibhs-25thiaz-bala-betaph


1781:tolhs-oxadiaz-bala-csdap


1782:ibhs-oxadiaz-gly-betadtrif


1783:ibhs-25thiaz-gly-betadito


1784:tolhs-25oxaz-bala-suabu


1785:bhs-ithiadiaz-bala-zdap


1786:bhs-25thioph-gly-psdap


1787:2py-24im-ala-zdap


1788:2pmhs-25methiaz-gly-betaph


1789:phhs-25oxaz-gly-psdap


1790:bhs-24thioph-bala-betabenfu


1791:bim-me25oxaz-gly-betadcph


1792:bhs-oxadiaz-bala-betahmph


1793:ibhs-ithiadiaz-bala-betafph


1794:ibhs-25oxaz-bala-betacph


1795:ibhs-25methiaz-gly-betaipro


1796:ibhs-24thiaz-gly-betabph


1797:2py-triaz-leu-betapy


1798:tolhs-nme35pyr-gly-zdapch


1799:bhs-thiadiaz-leu-betadcph


1800:tolhs-ithiadiaz-bala-beta34dcph


1801:phhs-25oxaz-bala-betampy


1802:tolhs-nme35pyr-gly-betabediox


1803:phhs-24thiaz-gly-betabenfu


1804:ibhs-24thioph-gly-betaanaphth


1805:ibhs-24thiaz-bala-betabthioph


1806:bhs-24thiaz-gly-betameph


1807:bhs-24thioph-bala-betaph


1808:ur-25oxaz-bala-zdap


1809:phhs-25thiaz-gly-betadcph


1810:ibhs-24thiaz-gly-betaphethio


1811:agua-24thioph-gly-psdap




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-75
1812: tolhs-24thiaz-bala-betadmoph


1813: phhs-nme35pyr-gly-betaheph


1814: bhs-ithiadiaz-gly-aspbzla


1815: cima-25methiaz-bala-psdap


1816: bim-25thiaz-bala-aspaba


1817: phhs-oxadiaz-bala-betahcbph


1818: phhs-me24thiaz-ala-betadcph


1819: bim-25oxaz-gly-betafph


1820: bhs-25methiaz-gly-betabenfu


1821:gua-42pym-gly-betabph


1822: bim-24thioph-bala-asppha


1823: ibhs-oxadiaz-bala-betamethi


1824: tolhs-24thiaz-bala-betabediox


1825: tolhs-25oxaz-bala-psdap


1826:ibhs-25thiaz-bala-beta35dbph


1827: ibhs-25oxaz-gly-betamesu


1828: ibhs-24thioph-gly-betambiph


1829: bhs-25oxaz-gly-betahcbph


1830: ibhs-24thioph-gly-betahc


1831:2py-25methiaz-gly-asppha


1832: phhs-oxadiaz-gly-betacbph


1833: ibhs-ithiadiaz-bala-betaipro


1834: bhs-25thiaz-ala-betacthioph


1835: phhs-25thiaz-gly-aspibua


1836:ibhs-25methiaz-bala-betamesu


1837: bim-42nmeim-bala-betabediox


1838: tolhs-me25thioph-gly-betadcph


1839: ibhs-25methiaz-bala-betafbph


1840: phhs-25oxaz-gly-beta35dbph


1841:phhs-24thioph-bala-betaet


1842: ibhs-25oxaz-gly-betadcphee


1843: phhs-25oxaz-gly-betadtrif


1844: hs-42nmeim-bala-zdap


1845: bim-25methiaz-gly-betaibph


1846:bim-thiadiaz-ala-betapy


1847: 2py-me24im-ala-betapy


1848: bhs-24thiaz-gly-betamethioph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-76-
1849:tolhs-24thiaz-gly-beta23meoph


1850:tolhs-nme35pyr-bala-zdaptb


1851:ibhs-nme35pyr-gly-betah35dc


1852:bhs-25thiaz-gly-betahph


1853:bhs-25thiaz-bala-betatbuph


1854:ur-24thioph-gly-betadcph


1855:tolhs-me25thiaz-gly-psdap


1856:ibhs-24thiaz-gly-betafu2


1857:bhs-ithiadiaz-gly-betathiobe


1858:bim-25fur-bala-betapy


1859:phhs-25thiaz-gly-betahmph


1860:tolhs-nme35pyr-bala-betadbph


1861:ibhs-oxadiaz-bala-betamesu


1862:ibhs-25oxaz-bala-betabediox


1863:tolhs-oxadiaz-bala-betabnaphth


1864:bhs-oxadiaz-bala-zdapee


1865:ibhs-24thiaz-bala-betafph


1866:tolhs-25methiaz-bala-betaibph


1867:bhs-24thioph-gly-betatrif


1868:3pmhs-42nmeim-bala-zdap


1869:phhs-nme35pyr-gly-betathioph


1870:tolhs-nme35pyr-bala-busu2be


1871:bhs-24thiaz-gly-betaoxope


1872:tolhs-24thiaz-gly-betatrif


1873:bhs-25methiaz-gly-betahmo


1874:tolhs-oxadiaz-gly-betahph


1875:phhs-ithiadiaz-gly-zdaptb


1876:bim-42nmeim-bala-betahmofu


1877:2py-thiadiaz-gly-zdap


1878:bhs-ithiadiaz-gly-betahmo


1879:bim-25thiaz-gly-aspibua


1880:bhs-nme35pyr-gly-betapy


1881:bhs-ithiadiaz-ala-betapy


1882:ibhs-nme35pyr-bala-betafphe


1883:bhs-53pyrazo-bala-betadcph


1884:ibhs-25methiaz-gly-betahcbph


1885:tolhs-25methiaz-gly-betaphethio




CA 02371604 2001-10-24
WO 00166618 PCTI~P00103469
-77
1886:bhs-24thiaz-bala-beta23meoph


1887:ibhs-nme35pyr-gly-zdap


1888:bhs-25thiaz-gly-betadcphtb


1889:gua-26py-gly-betacbph


1890:2py-25th iaz-g ly-betath
io3


1891:tolhs-24thioph-bala-betapyee


1892:bhs-oxadiaz-gly-betaoxaz


1893:ibhs-25thiaz-bala-betahdbph


1894:ibhs-ithiadiaz-bala-betaheph


1895:ibhs-24thiaz-gly-betahmofu


1896:tolhs-24thioph-bala-betaoxaz


1897:phhs-25methiaz-gly-betapbiph


1898:tolhs-24thiaz-gly-betamethi


1899:tolhs-24thiaz-bala-betamethioph


1900:bhs-ithiadiaz-bala-betapyee


1901:bhs-25thiaz-bala-zdaptb


1902:ibhs-nme35pyr-bala-beta34meoph


1903:tolhs-me25thioph-ala-zdap


1904:ibhs-25methiaz-gly-betaamibe


1905:phhs-25oxaz-bala-betabdimo


1906:2py-triaz-gly-betapy


1907:ibhs-25oxaz-bala-betadcphch


1908:bhs-oxadiaz-nmgly-betadmph


1909:bhs-24thiaz-bala-beta35dbph


1910:tolhs-24thioph-gly-betapy


1911:gua-26py-gly-betacthioph


1912:bhs-25oxaz-bala-betapy


1913:dhpyrr-25thiaz-gly-betapy


1914:tolhs-24thioph-bala-betapym


1915:ibhs-24thioph-bala-betapbiph


1916:gua-26py-gly-betaipro


1917:bim-oxadiaz-bala-aspibua


1918:tolhs-nme35pyr-bala-betadtrif


1919:tolhs-25thiaz-gly-betafluo


1920:phhs-oxadiaz-bala-beta23meoph


1921:tolhs-25oxaz-bala-beta34dcph


1922:2py-me24oxaz-ala-betapy




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-78
1923:tolhs-25methiaz-gly-betapym


1924:phhs-nme35pyr-gly-betahdcph


1925:tolhs-oxadiaz-gly-betafbph


1926:tolhs-25methiaz-bala-csdap


1927:bhs-24im-gly-psdap


1928:2py-me25oxaz-bala-beta34meoph


1929:ibhs-25oxaz-gly-betahdbph


1930:ibhs-oxadiaz-bala-betahcbph


1931:phhs-24thioph-bala-csdap


1932:tolhs-24thiaz-gly-betameph


1933:bhs-24thioph-gly-betacbph


1934:ibhs-24thiaz-gly-psdapee


1935:phhs-24thiaz-gly-betafluo


1936:gua-42pym-gly-betacthioph


1937:bhs-25thiaz-bala-betadhbfu


1938:bhs-oxadiaz-bala-betadhbfu


1939:phhs-25methiaz-gly-busu2be


1940:phhs-24thiaz-gly-psdap


1941:ibhs-24thioph-bala-betathiobe


1942;phhs-ithiadiaz-gly-betatbuph


1943:tolhs-25methiaz-bala-betahmofu


1944:sabhs-24thioph-gly-psdap


1945;ibhs-25oxaz-gly-betaoxope


1946:tolhs-25thiaz-gly-beta34dcph


1947:phhs-nme35pyr-gly-betabph


1948:phhs-25thiaz-gly-betatrif


1949:bhs-ithiadiaz-ala-betadito


1950:bim-25thiaz-ala-betameph


1951:2py-35fur-gly-betadcph


1952:ibhs-25methiaz-gly-betabdimo


1953:cima-24thioph-bala-psdap


1954:phhs-24thioph-gly-betafph


1955:ibhs-ithiadiaz-bala-betafphe


1956:bim-24im-leu-betapy


1957:bhs-25thioph-gly-betacph


1958:impy-24thiaz-bala-betainyl


1959:bim-25methiaz-bala-asppha




CA 02371604 2001-10-24
WO 00166618 PCTlEP00l03469
-79-
1960:bhs-24thioph-bala-betadcphtb


1961:ibhs-oxadiaz-bala-psdaptb


1962:2py-me24thioph-gly-psdap


1963:2pmhs-24thiaz-bala-betamethioph


1964:ibhs-25methiaz-bala-betampy


1965:bhs-24thiophme-gly-betameph


1966:bhs-ithiadiaz-gly-betatrif


1967:dhim-26py-ala-betatbuph


1968:thpym-25thiaz-gly-betadcph


1969:2py-thiadiaz-ala-betapy


1970:~2py-25methiaz-bala-betaoxope


1971:tolhs-25methiaz-gly-ibsdap


1972:ibhs-ithiadiaz-gly-betaoxaz


1973:phhs-25thiaz-bala-asppha


1974:2py-42nmeim-gly-betampy


1975:2py-26py-ala-betapy


1976:phhs-24thiaz-gly-betadcphtb


1977:3pmhs-24thioph-bala-betapy


1978:2py-25thiaz-bala-aspbzla


1979:gua-42pym-gly-betahmo


1980:gua-26py-gly-betaamibe


1981:tolhs-25methiaz-gly-zdapee


1982:ibhs-25oxaz-gly-psdapch


1983:bhs-25thiaz-nmgly-betadmph


1984:bhs-nme35pyr-bala-betadmoph


1985:agua-25thiaz-gly-betadcph


1986:phhs-25methiaz-gly-betameph


1987:bhs-24thiaz-gly-beta35dbph


1988:ibhs-ithiadiaz-gly-betafphe


1989:bim-25oxaz-leu-betapy


1990:phhs-ithiadiaz-bala-betahmph


1991:2py-24thioph-bala-betaet


1992:2py-me24thiaz-gly-betaph


1993:2py-24im-ala-betadcph


1994:bhs-25thiaz-gly-betadmoph


1995:phhs-ithiadiaz-bala-betaet


1996:ibhs-25thiaz-bala-betaphethio




CA 02371604 2001-10-24
W~ 00166618 PCTIEP00103469
-80
1997:phhs-oxadiaz-bala-betahbcph


1998:ibhs-25methiaz-bala-betafphe


1999:ibhs-25thiaz-gly-suabu


2000:bim-24thiaz-ala-betameph


2001:phhs-me25thiaz-bala-betaph


2002:ibhs-25thiaz-gly-betapyr


2003:bhs-me25thioph-bala-betaph


2004:bhs-25oxaz-bala-aspaba


2005:2pmhs-25thiaz-bala-betathioph


2006:tolhs-oxadiaz-bala-psdap


2007:bhs-nme35pyr-gly-betaoxaz


2008:tolhs-25thiaz-gly-beta23meoph


2009:phhs-25methiaz-gly-betaamibe


2010:gua-25thioph-gly-betapy


2011:2py-nme35pyr-gly-psdap


2012:ibhs-ithiadiaz-gly-betahdbph


2013:2py-25oxaz-gly-betacbph


2014:bim-me24thioph-leu-zdap


2015:bhs-25thiaz-ala-beta13bendi


2016:phhs-24thioph-gly-betatrif


2017:2py-ith iad iaz-gly-betapy


2018:phhs-nme35pyr-gly-betapytb


2019:ibhs-ithiadiaz-gly-betaanaphth


2020:bhs-nme35pyr-ala-betaanaphth


2021:tolhs-nme35pyr-gly-betapych


2022:2py-me25thioph-bala-psdap


2023:ibhs-24thiaz-gly-betaet


2024.tolhs-24thioph-gly-beta3quin


2025:tolhs-24thiaz-bala-betaoxope


2026:ibhs-25methiaz-gly-beta34meoph


2027.ibhs-25oxaz-bala-betambiph


2028:phhs-25oxaz-gly-betafbph


2029:tolhs-24thiaz-gly-betathio3


2030:phhs-ithiadiaz-gly-betaipro


2031:phhs-25oxaz-gly-betacthioph


2032:bhs-25thiaz-bala-betaibph


2033:impy-24thioph-nmgly-psdap




CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-81
2034:bhs-24im-gly-zdap


2035:bhs-thiadiaz-leu-betapy


2036:gua-25thiophme-gly-betapy


2037:bhs-24thiaz-gly-betafluo


2038:toihs-oxadiaz-bala-betathioph


2039:bhs-24im-ala-betapy


2040:bhs-24thiaz-bala-betabph


2041:bim-25oxaz-bala-betathioph


2042:bhs-nme35pyr-gly-betaamibe


2043:phhs-25oxaz-gly-beta23meoph


2044:ibhs-ithiadiaz-gly-betabdimo


2045:phhs-25methiaz-gly-betaipro


2046:phhs-24thiaz-gly-beta34meoph


2047:phhs-25thiaz-gly-betafluo


2048:bhs-25methiaz-bala-betaanaphth


2049:tolhs-25thiaz-bala-psdapee


2050:tolhs-24thiaz-gly-betafphe


2051:bhs-24thioph-gly-betafluo


2052:phhs-nme35pyr-gly-betahni


2053:2py-me24thioph-bala-betapy


2054:ibhs-25methiaz-gly-betafbph


2055:2py-nme35pyr-bala-aspaba


2056:bhs-24thiaz-gly-betatbuph


2057:2py-42pym-gly-betapy


2058:tolhs-24thiaz-bala-betahmofu


2059:ibhs-25thiaz-gly-betatos


2060:ibhs-nme35pyr-bala-suabu


2061:ibhs-25methiaz-gly-betamethioph


2062:ibhs-25thiaz-bala-betadito


2063:hyd-24thiaz-bala-betameph


2064:tolhs-nme35pyr-gly-betacph


2065:bhs-25oxaz-ala-betafphe


2066:bhs-oxadiaz-gly-aspbzla


2067:tolhs-24thiaz-bala-ibsdap


2068:bim-ithiadiaz-leu-betadcph


2069:2py-24thioph-gly-betaol


2070:tolhs-24thiaz-gly-betamesu




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-82
2071:ibhs-24thiaz-gly-betahdcph


2072:bhs-25methiaz-nmgly-beta3quin


2073:ibhs-24thioph-gly-betaphethio


2074:bhs-24thioph-bala-betathiobe


2075:bhs-25thiaz-gly-asppha


2076:phhs-nme35pyr-bala-betaphethioa


2077:2py-25methiaz-leu-betadcph


2078:tolhs-ithiadiaz-bala-betafphe


2079:bhs-25oxaz-bala-betadmph


2080:bhs-nme35pyr-bala-betaftrif


2081:tolhs-25methiaz-gly-betapyee


2082:bim-oxadiaz-leu-psdap


2083:tolhs-ithiadiaz-gly-betahc


2084:gua-25thiaz-gly-betahc


2085:2py-53pyrazo-gly-zdap


2086:nmhs-42pym-gly-betainyl


2087:tolhs-24thiaz-gly-betainyl


2088:phhs-25oxaz-bala-psdapch


2089:bhs-24thiaz-gly-betathiome


2090:bhs-nme35pyr-gly-betabediox


2091:phhs-25thiaz-gly-betahph


2092:bhs-24thiaz-nmgly-betabpy


2093:ibhs-25methiaz-bala-betafu3


2094:phhs-24thioph-gly-betaoxope


2095:bhs-25methiaz-gly-busu2be


2096:dhim-24thiaz-ala-zdap


2097:bhs-ithiadiaz-bala-betainyl


2098:phhs-25methiaz-gly-betaomebendi


2099:bim-52thiaz-ala-betameph


2100:bim-35thioph-bala-zdap


2101:ibhs-25thiaz-bala-aspbzla


2102:ibhs-25thiaz-gly-busu2be


2103:tolhs-nme35pyr-gly-betaomebendi


2104;phhs-25methiaz-gly-betaet


2105:bhs-24thiaz-gly-betahdcph


2106:bim-42nmeim-gly-betah35dc


2107:bhs-me24thioph-gly-betapy




CA 02371604 2001-10-24
WO OOI66618 . PCTIEP00103469
-83
2108:phhs-25thiaz-gly-zdapee


2109:ibhs-nme35pyr-bala-betadbph


2110:tolhs-me25thiaz-giy-betaph


2111:bhs-me25thioph-bala-zdap


2112:impy-25oxaz-bala-betadmoph


2113:tolhs-25thiaz-bala-betal3bendi


2114:bhs-35fur-gly-psdap


2115:gua-25thioph-gly-betaph


2116:ibhs-25oxaz-bala-betaamibe


2117:2py-24oxaz-leu-betadcph


2118:ibhs-ithiadiaz-gly-betahmofu


2119:bim-25thioph-ala-betapy


2120:ibhs-ithiadiaz-gly-betadcphee


2121:tolhs-me25oxaz-gly-betadcph


2122:tolhs-25methiaz-bala-betaheph


2123:ibhs-ithiadiaz-gly-betapy


2124:bhs-35py-ala-betapy


2125:bhs-35thioph-bala-psdap


2126:tolhs-me24thioph-bala-zdap


2127:phhs-25methiaz-gly-betahdcph


2128:bhs-25thiaz-bala-psdapee


2129:bhs-me25thioph-gly-beta34meoph


2130:phhs-oxadiaz-gly-betahdcph


2131:tolhs-25oxaz-gly-betaanaphth


2132:tolhs-25thiaz-bala-csdap


2133:2py-ithiadiaz-leu-zdap


2134:ibhs-25oxaz-bala-betamethi


2135:bhs-25oxaz-bala-aspbzla


2136:phhs-nme35pyr-bala-betah35dc


2137:ibhs-24thioph-bala-betadcphch


2138:phhs-25methiaz-bala-betathiome


2139:2py-52thiaz-ala-betapy


2140:ibhs-24thioph-gly-betabdimo


2141:dimethpym-25thiaz-gly-betameph


2142:bhs-25methiaz-gly-betaftrif


2143:tolhs-24thiaz-gly-betacph


2144:bhs-oxadiaz-bala-betapytb




CA 02371604 2001-10-24
WO OO1G6618 PCTlEP00103469
_84_
2145:ibhs-oxadiaz-bala-betafbph


2146:ibhs-25thiaz-gly-betacbph


2147:phhs-24thioph-bala-betafluo


2148:phhs-me24thiaz-bala-beta34meoph


2149:tolhs-25thiaz-bala-betapyr


2150:phhs-25oxaz-bala-betadhbfu


2151:ibhs-25oxaz-bala-betadito


2152:bhs-24thioph-gly-betameph


2153:bhs-24thioph-bala-betacbph


2154:bim-25oxaz-gly-aspbzla


2155:impy-24thioph-gly-beta34meoph


2156:bhs-ithiadiaz-nmgly-betadmoph


2157:bim-35thioph-ala-betapy


2158:tolhs-25thiaz-bala-betadmph


2159:phhs-24thioph-bala-betaphethioa


2160:ibhs-25oxaz-bala-betafu2


2161:ibhs-nme35pyr-gly-betatrif


2162:2py-24thiaz-gly-beta3quin


2163:2pmhs-25thiaz-gly-psdap


2164:bhs-25oxaz-gly-betatos


2165:tolhs-25methiaz-gly-beta3quin


2166:tolhs-24thioph-bala-betabthioph


2167:impy-25methiaz-bala-betamesu


2168:phhs-25oxaz-bala-psdapee


2169:tolhs-25thiaz-gly-betah35dc


2170:tolhs-24thioph-bala-betafu3


2171:bhs-25methiaz-gly-betabdimo


2172:bhs-25fur-gly-betadcph


2173:phhs-ithiadiaz-bala-psdapch


2174:tolhs-25oxaz-gly-betadito


2175:tolhs-oxadiaz-gly-betamesu


2176:bhs-25oxaz-bala-betabenfu


2177:ibhs-25methiaz-gly-betadcph


2178:bhs-24thioph-gly-betadito


2179:ibhs-24thiaz-bala-betaoxope
.


2180:tolhs-25methiaz-bala-betampy


2181:ibhs-ithiadiaz-bala-aspaba




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-85
2182: 2py-me25oxaz-ala-betadcph


2183: ibhs-24thioph-gly-betapytb


2184: ibhs-ithiadiaz-bala-betainyl


2185: phhs-me25thiaz-gly-psdap


2186: phhs-oxadiaz-g1y-betahb


2187: bhs-nme35pyr-ala-beta34dcph


2188: phhs-me24thiaz-ala-zdap


2189: bhs-42nmeim-leu-betapy


2190: tolhs-24thiaz-gly-betaftrif


2191:ibhs-oxadiaz-gly-betahmph


2192: tolhs-ithiadiaz-bala-betahb


2193: bhs-35thioph-leu-betadcph


2194: bhs-25thiaz-bala-betadcph


2195: phhs-nme35pyr-gly-betapyr


2196:ibhs-ithiadiaz-gly-zdap


2197: phhs-25oxaz-bala-betahdcph


2198: bhs-oxadiaz-gly-betaibph


2199: 2py-me24thioph-leu-betaph


2200: tolhs-24thioph-gly-beta34dcph


2201:bhs-24thiaz-nmgly-betacph


2202: bhs-25oxaz-bala-betapyr


2203: bhs-25fur-leu-zdap


2204: impy-24oxaz-gly-betameph


2205: bhs-nme35pyr-gly-betahb


2206:tolhs-me24thiaz-bala-psdap


2207: ibhs-24thioph-gly-beta35dbph


2208: ibhs-24thioph-bala-betathio3


2209: bhs-24thiaz-bala-asppha


2210: bhs-24thioph-ala-betaanaphth


2211:ibhs-24thioph-bala-betahph


2212: tolhs-nme35pyr-bala-asppha


2213: bim-thiadiaz-leu-zdap


2214: 2py-35fu r-bala-betapy


2215: phhs-24thioph-bala-betathioph


2216:phhs-ithiadiaz-bala-betadhbfu


2217: bhs-25thiaz-nmgly-betameph


2218: tolhs-ithiadiaz-gly-betahb




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-86
2219:2py-ithiadiaz-gly-aspibua


2220:ibhs-25methiaz-bala-betamethioph


2221:bhs-oxadiaz-gly-betaet


2222:ibhs-nme35pyr-gly-betatos


2223:bhs-me25oxaz-gly-psdap


2224:bhs-25oxaz-bafa-zdapee


2225:bhs-26py-gly-beta13bendi


2226:bhs-25fur-ala-betadcph


2227:ibhs-24thioph-gly-zdapch


2228:tolhs-25thiaz-bala-betadcphtb


2229:phhs-24thioph-bala-betadbph


2230:2py-25oxaz-bala-aspbzla


2231:2py-me25thioph-ala-beta34meoph


2232:ibhs-25thiaz-bala-beta34meoph


2233:ibhs-24thioph-bala-zdap


2234:phhs-24thiaz-bala-betathio3


2235:bhs-24thioph-bala-betatrif


2236:bhs-nme35pyr-bala-betadito


2237:phhs-nme35pyr-gly-betacbph


2238:bhs-24thioph-ala-betaoxaz


2239:impy-25thiaz-bala-betaphethioa


2240:2py-25oxaz-bala-betafu3


2241:2py-oxadiaz-ala-betapy


2242:ibhs-25methiaz-bala-betaet


2243:ibhs-ithiadiaz-gly-betatbuph


2244:phhs-24thioph-bala-betaol


2245:phhs-25thiaz-bala-beta23meoph


2246:phhs-25oxaz-bala-betabthioph


2247:bim-24im-bala-psdap


2248:bim-nme35pyr-gly-aspaba


2249:ibhs-25oxaz-bala-betaimid


2250:impy-24thiaz-gly-betaipr


2251:tolhs-25thiaz-bala-betapbiph


2252:phhs-25oxaz-bala-betadcph


2253:ibhs-ithiadiazgly-beta-4bph


2254:bhs-oxadiaz-gly-betah35dc


2255:phhs-oxadiaz-gly-betaipro




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
_87_
2256:bhs-25methiaz-nmgly-betathio3


2257:bim-35thioph-leu-zdap


2258:phhs-25oxaz-bala-betaipr


2259:ibhs-25methiaz-gly-zdapch


2260:bim-me25thiaz-bala-zdap


2261:phhs-nme35pyr-bala-betaamibe


2262:bhs-25thiaz-bala-aspaba


2263:bhs-24thiaz-gly-betathioph


2264:bhs-25oxaz-gly-betaphethio


2265:bhs-ithiadiaz-bala-betabediox


2266:phhs-nme35pyr-gly-betabnaphth


2267:bhs-nme35pyr-gly-betadtrif


2268:tolhs-25thiaz-bala-betainyl


2269:bhs-24thioph-gly-betabnaphth


2270:phhs-ithiadiaz-bala-betacbph


2271:bhs-25methiaz-bala-betatbuph


2272:bhs-25methiaz-ala-betathio3


2273:bim-25methiaz-gly-zdap


2274:tolhs-oxadiaz-gly-betafu2


2275:ibhs-24thiaz-bala-beta35dbph


2276:bhs-nme35pyr-gly-betadito


2277:bhs-oxadiaz-ala-ibsdap


2278:ibhs-25methiaz-gly-beta13bendi


2279:phhs-24thioph-bala-psdap


2280:ibhs-ithiadiaz-bala-betatos


2281:tolhs-25thiaz-gly-psdapch


2282:bhs-25methiaz-gly-betadhbfu


2283:phhs-24thiaz-gly-betaipro


2284:ibhs-oxadiaz-gly-zdap


2285:tolhs-nme35pyr-bala-betafphe


2286:bhs-25thiaz-ala-betaoxaz


2287:ibhs-24thioph-bala-betaet


2288:ibhs-24thiaz-bala-betafu3


2289:bhs-25oxaz-ala-ibsdap


2290:bhs-25methiaz-nmgly-betadito


2291:bim-24thioph-gly-betapbiph


2292:ibhs-25thiaz-bala-betadtrif




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
_88_
2293:tolhs-25methiaz-bala-betah35dc


2294:phhs-25methiaz-gly-betabdimo


2295:2py-25oxaz-bala-aspibua


2296:ibhs-25thiaz-bala-betahmofu


2297:phhs-oxadiaz-gly-betathiome


2298:tolhs-oxadiaz-gly-betaomebendi


2299:tolhs-25thiaz-gly-betabmph


2300:ibhs-oxadiaz-bala-betahdcph


2301:2py-me24thioph-leu-beta34meoph


2302:phhs-nme35pyr-gly-betabediox


2303:ibhs-nme35pyr-bala-betaibph


2304:2py-me25thioph-bala-beta34meoph


2305:bhs-24thiaz-bala-betatos


2306:bhs-25thiaz-gly-betaol


2307:phhs-25oxaz-gly-betahb


2308:ibhs-oxadiaz-bala-betaphethioa


2309:tolhs-25thiaz-bala-betahmofu


2310:bhs-nme35pyr-ala-betahph


2311:ibhs-25oxaz-bala-betaibph


2312:tolhs-25oxaz-bala-betadmph


2313:2py-me25oxaz-bala-zdap


2314:bhs-24thiaz-gly-betacph


2315:bim-oxadiaz-ala-zdap


2316:tolhs-25oxaz-bala-betamethi


2317:2py-25thioph-ala-betadcph


2318:bhs-24thiaz-nmgly-ibsdap


2319:bim-42nmeim-gly-busu2be


2320:phhs-me24thioph-ala-betadcph


2321:bhs-24thiaz-nmgly-betadhbfu


2322:2py-me25thiaz-bala-betapy


2323:bim-25thioph-gly-zdap


2324:tolhs-25oxaz-gly-betahmofu


2325:bhs-25methiaz-gly-betahmofu


2326:phhs-ithiadiaz-bala-suabu


2327:ibhs-25oxaz-gly-betamethi


2328:gua-26py-gly-betapy


2329:tolhs-25oxaz-gly-betapy




CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
_ 89
2330:bhs-me25oxaz-ala-betaph


2331:tolhs-nme35pyr-gly-betambiph


2332:bhs-24thioph-gly-betathiome


2333:phhs-25thiaz-gly-betaet


2334:tolhs-ithiadiaz-bala-betapyr


2335:phhs-24thioph-bala-zdapch


2336:tolhs-25methiaz-gly-zdap


2337:ibhs-24thiaz-gly-betacbph


2338:bhs-oxadiaz-bala-betahph


2339:tolhs-24thiaz-bala-betafu2


2340:ibhs-24thiaz-gly-psdap


2341:ibhs-ithiadiaz-bala-betabenfu


2342:bim-25oxaz-bala-psdap


2343:phhs-me25oxaz-leu-betapy


2344:ibhs-nme35pyr-bala-betabph


2345:bim-me25thioph-leu-betadcph


2346:bhs-ithiadiaz-bala-betabenfu


2347:phhs-25methiaz-bala-betabithioph


2348:bhs-nme35pyr-bala-psdapee


2349:ibhs-24thioph-bala-betabdimo


2350:ibhs-24thioph-gly-betaoxope


2351:bim-42pym-ala-zdap


2352:gua-26py-gly-suabu


2353:ibhs-25thiaz-bala-betaipro


2354:phhs-ithiadiaz-gly-betapytb


2355:2pmhs-25thiaz-gly-betameph


2356.bim-me24thioph-bala-psdap


2357:phhs-25thiaz-bala-betaphethio


2358:tolhs-oxadiaz-bala-betahbcph


2359:bhs-26py-gly-psdap


2360:bhs-24thiaz-gly-betaanaphth


2361:dhim-2thioph-gly-betameph


2362:2py-me24thioph-leu-betadcph


2363:tolhs-24thiaz-bala-betabmph


2364:bhs-25oxaz-bala-beta35dbph


2365:tolhs-25methiaz-gly-betadhbfu


2366:bhs-24thioph-bala-betafluo




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103489
-90
2367:tolhs-24thiaz-bala-betaol


2368:bim-24thioph-gly-betadbph


2369:phhs-24thioph-bala-betabph


2370:phhs-nme35pyr-bala-betacbph


2371:tolhs-ithiadiaz-bala-betadhbfu


2372:2py-24oxaz-gly-betainyl


2373:ibhs-24thioph-gly-zdaptb


2374:2py-25fur-leu-betadcph


2375:bhs-24thiaz-gly-betaimid


2376:ibhs-25methiaz-bala-beta13bendi


2377:bhs-24thiaz-bala-betapyr


2378:ibhs-24thiaz-bala-suabu


2379:tolhs-oxadia~-gly-betambiph


2380:bhs-oxadiaz-nmgly-betathioph


2381:phhs-25methiaz-gly-betabediox


2382:ibhs-25thiaz-gly-betameph


2383:phhs-24thioph-bala-betaipro


2384:bhs-24chin-ala-betameph


2385:tolhs-25oxaz-gly-betainyl


2386:2py-25oxaz-bala-betapy


2387:tolhs-25methiaz-gly-betacph


2388:ibhs-25oxaz-bala-beta
13bendi


2389:tolhs-25oxaz-gly-beta3quin


2390:ibhs-25oxaz-bala-zdap


2391:tolhs-24thioph-bala-beta13bendi


2392:phhs-me24oxaz-bala-psdap


2393:bim-24thioph-bala-betatos


2394:tolhs-me25oxaz-ala-zdap


2395:bhs-me24oxaz-bala-zdap


2396:bhs-25thiaz-bala-betadbph


2397:phhs-ithiadiaz-gly-betainyl


2398:ibhs-ithiadiaz-gly-betapytb


2399:ibhs-24thiaz-gly-betah35dc


2400:tolhs-24thiaz-gly-betatbuph


2401:phhs-24thiaz-bala-betampy


2402:bhs-53pyrazo-bala-betapy


2403:2py-25oxaz-bala-betadcph




CA 02371604 2001-10-24
WO 00/66618
PCTlEP00103469
_91_
2404: phhs-me24thioph-ieu-betapy
2405: tolhs-ithiadiaz-bala-betaanaphth
2406: ibhs-oxadiaz-bala-betaph
2407: phhs-25methiaz-gly-betafu2
2408: phhs-24thioph-gly-betadbph
2409: phhs-24thioph-bala-psdapee
2410: ibhs-24thiaz-bala-betacph
2411: bhs-me25thiaz-giy-betadcph
2412: phhs-oxadiaz-bala-betabpy
2413: ibhs-24thioph-gly-beta34dcph
2414: ibhs-25thiaz-gly-betapbiph
2415: tolhs-24thiaz-bala-beta34meoph
2416: tolhs-ithiadiaz-bala-betapbiph
2417: phhs-nme35pyr-bala-betadcph
2418: 2pmhs-25methiaz-giy-betathiome
2419: bhs-me25thiaz-bala-psdap
2420: phhs-ithiadiaz-gly-betabenfu
2421: 2py-nme35pyr-leu-betadcph
2422: phhs-24thioph-bala-betadmph
2423: bhs-24thioph-bala-betahcbph
2424: 2py-25methiaz-bala-asppha
2425: 2py-2gpy_giy-betampy
2426: ibhs-nme35pyr-gly-zdapch
2427: tolhs-me24thiaz-ala-betapy
2428: toihs-nme35pyr-gly-betapbiph
2429: phhs-ithiadiaz-gly-betapyee
2430: bhs-25oxaz-gly-beta34meoph
2431: 2py-35thioph-leu-betadcph
2432: ibhs-nme35pyr-gly-betabph
2433: bhs-ithiadiaz-gly-betaphethio
2434: tolhs-25thiaz-gly-zdapch
2435: 2py-24thioph-ala-zdap
2436: toihs-ithiadiaz-gly-betahph
2437: phhs-25methiaz-bala-betaphethioa
2438: ibhs-25oxaz-gly-betah35dc
2439: gua-25thioph-gly-betaphethio
2440: bim-35fur-gly-psdap


CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-92
2441: ibhs-ithiadiaz-bala-betaftrif
2442: tolhs-24thiaz-gly-beta34meoph
2443: bhs-25methiaz-bala-betacthioph
2444: bhs-nme35pyr ala-betaoxaz
2445: 2py-me24thioph-gly-zdap
2446: 2py-25oxaz-gly-betambiph
2447: bhs-42nmeim-gly-psdap
2448: bhs-oxadiaz-gly-psdapee
2449: phhs-ithiadiaz-gly-betafph
2450: thazep-42pym-gay-beta13bendi
2451: phhs-25methiaz-bala-betabmph
2452: bhs-25methiaz-bala-betapbiph
2453: phhs-nme35pyr-gly-suabu
2454: ibhs-ithiadiaz-bala-betamethioph
2455: 2pmhs-24thioph-gly-betafph
2456: tolhs-24thiaz-gly-betacbph
2457: phhs-25thiaz-bala-betathio3
2458: ibhs-oxadiaz-bala-betamethioph
2459: ibhs-25thiaz-gly-aspibua
2460: bhs-42nmeim-bala-betadcph
2461: phhs-25oxaz-bala-betaomebendi
2462: phhs-nme35pyr-gly-asppha
2463: ibhs-24thiaz-baia-betainyl
2464: bim-25oxaz-gly-aspibua
2465: bhs-ithiadiaz-ala-betafphe
2466: bhs-25oxaz-bala-betafphe
2467: ibhs-ithiadiaz-gly-betaibph
2468: gua-26py-gly-betabnaphth
2469: ibhs-25oxaz-gly-betathioph
2470: phhs-25methiaz-gly-betathiobe
2471: ibhs-24thiaz-gly-betadbph
2472: tolhs-ithiadiaz-gly-betabthioph
2473: bhs-oxadiaz-gly-busu2be
2474: phhs-24thioph-gly-betaphethioa
2475: bhs-24thiaz-ala-betameph
2476: tolhs-25thiaz-bala-betaol
2477: bhs-ithiadiaz-bala-betahmofu


CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-93
2478: phhs-ithiadiaz-bala-betaph


2479: bhs-35fur-gly-betapy


2480: ibhs-24thioph-bala-betapych


2481: phhs-25oxaz-gly-beta13bendi


2482: bhs-25thiaz-ala-betadito


2483: bhs-ithiadiaz-bala-psdap


2484: bim-24thioph-bala-betaipro


2485: phhs-24thioph-bala-beta34dcph


2486: tolhs-me24thioph-leu-betapy


2487:phhs-25methiaz-gly-betahmph


2488: tolhs-oxadiaz-gly-betatbuph


2489: bhs-me24thioph-bala-zdap


2490: phhs-24thioph-gly-betahmo


2491: bhs-nme35pyr-gly-betabmph


2492:bim-24thioph-gly-zdap


2493: ibhs-25thiaz-bala-betahc


2494: ibhs-ithiadiaz-bala-zdaptb


2495: bhs-24thiaz-gly-betadcphee


2496: ibhs-24thioph-bala-betacbph


2497:ibhs-ithiadiaz-bala-betaph


2498: ibhs-25methiaz-gly-betahdcph


2499: phhs-24thiaz-bala-betafbph


2500: phhs-25oxaz-gly-betadhbfu


2501: bhs-42oxaz-leu-zdap


2502:phhs-ithiadiaz-gly-betaomebendi


2503: phhs-24thiaz-bala-beta4bph


2504: bhs-24thioph-bala-betaipro


2505: phhs-oxadiaz-bala-betahc


2506: tolhs-25oxaz-bala-betadito


2507:bhs-nme35pyr-gly-betapbiph


2508: bhs-25methiaz-gly-betameph


2509: ibhs-25oxaz-bala-beta4bph


2510: ibhs-ithiadiaz-bala-betadtrif


2511: bhs-ithiadiaz-gly-betabph


2512:bhs-25oxaz-bala-beta13bendi


2513: tolhs-25oxaz-bala-betafluo


2514: tolhs-25thiaz-bala-aspibua




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-94-
2515: ibhs-24thiaz-gly-betapytb


2516: tolhs-me25oxaz-leu-psdap


2517: phhs-25methiaz-bala-betahph


2518: bhs-24thioph-ala-betadhbfu


2519: bim-24thiaz-phg-zdap


2520: bhs-me25thiaz-bala-betapy


2521: 2py-35fur-bala-psdap


2522: phhs-me25thioph-ala-betadcph


2523: bhs-me25thiaz-gly-betaph


102524: phhs-25thiaz-gly-asppha


2525: phhs-25methiaz-gly-betadcphtb


2526: ibhs-nme35pyr-bala-betapbiph


2527: phhs-ithiadiaz-gly-betadtrif


2528: bhs-24thiaz-gly-betabdimo


152529: bhs-25methiaz-ala-betabnaphth


2530: 2py-me25thiaz-leu-zdap


2531: ibhs-24thiaz-gly-betaipr


2532: dhim-25thioph-gly-betahcbph


2533: tolhs-me24thiaz-leu-beta34imeoph


202534: bhs-25thiaz-bala-betaipro


2535: bim-me24thiaz-ala-psdap


2536: gua-25thioph-gly-betapbiph


2537: 2pmhs-24thioph-gly-betaph


2538: bhs-24thioph-bala-betaibph


252539. tolhs-24thioph-bala-betabnaphth


2540: bhs-nme35pyr-bala-betampy


2541: bim-ithiadiaz-bala-aspbzla


2542: ur-25thioph-gly-zdap


2543: bhs-24thioph-gly-betatos


302544: bhs-nme35pyr-gly-aspaba


2545: tolhs-ithiadiaz-gly-zdapch


2546: ibhs-24thioph-gly-betapyr


2547: bhs-ithiadiaz-bala-betaibph


2548: bhs-25methiaz-bala-betathiobe


352549: ibhs-25thiaz-bala-beta13bendi


2550: bhs-24thioph-ala-betainyl


2551: 2pmhs-25oxaz-gly-betadito




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-95
2552:tolhs-oxadiaz-bala-ibsdap


2553:bim-me24oxaz-leu-betadcph


2554:phhs-25thiaz-bala-betainyl


2555:phhs-me24oxaz-bala-betaph


2556:bhs-23thioph-gly-betapy


2557:tolhs-25methiaz-bala-betafbph


2558:bhs-oxadiaz-bala-betabenfu


2559:phhs-24thiaz-gly-betadcph


2560:phhs-25oxaz-gly-betaomebendi


2561:tolhs-nme35pyr-gly-betadcph


2562:ibhs-24thioph-bala-zdapch


2563:tolhs-nme35pyr-gly-betah35dc


2564:ibhs-25thiaz-gly-betabthioph


2565:tolhs-24thioph-gly-betabediox


2566:bhs-25thiaz-gly-betathiobe


2567:phhs-oxadiaz-bala-beta3quin


2568:ibhs-25thiaz-gly-betaph


2569:phhs-25thiaz-gly-betampy


2570:ibhs-nme35pyr-gly-betabdimo


2571:2py-25methiaz-hphe-psdap


2572:phhs-ithiadiaz-gly-betahni


2573:bhs-nme35pyr-ala-betafphe


2574:2py-52thiaz-ala-betameph


2575:gua-24thiaz-gly-betafph


2576:ibhs-24thioph-bala-beta4bph


2577:bhs-24thiaz-bala-betaheph


2578:ibhs-25methiaz-giy-betaph


2579:phhs-nme35pyr-gly-betahcbph


2580:phhs-ithiadiaz-bala-betah35dc


2581:bhs-oxadiaz-bala-beta23meoph


2582:bim-25thiaz-gly-betaibph


2583:tolhs-25methiaz-bala-beta34dcph


2584:tolhs-24thioph-gly-zdapee


2585:tolhs-oxadiaz-gly-betahmo


2586:4pmhs-24oxaz-gly-betameph


2587:ibhs-ithiadiaz-bala-betafbph


2588:bhs-oxadiaz-bala-betaftrif




CA 02371604 2001-10-24
WO 00/66618 PCTlEP00103469
-96
2589: gua-24oxaz-gly-betafu2


2590: tolhs-me24thiaz-gly-betadcph


2591: bhs-25thiaz-bala-betathiome


2592: impy-25oxaz-gly-betameph


2593:ibhs-25thiaz-bala-betafbph


2594: tolhs-24thiaz-bala-betaipro


2595: tolhs-25oxaz-bala-betapytb


2596: bim-me24thioph-leu-betapy


2597: tolhs-24thioph-gly-betaphethio


2598:Zpy-25thioph-gly-psdap


2599: bhs-25thiaz-gly-betahmo


2600: tolhs-oxadiaz-bala-aspaba


2601: bhs-oxadiaz-leu-zdap


2602: hs-24thiaz-bafa-betapy


2603:bhs-25thiaz-gly-betaoxope


2604: bhs-24thioph-bala-betathioph


2605: tolhs-ithiadiaz-bala-betabpy


2606: phhs-ithiadiaz-gly-betamethi


2607: phhs-24thiaz-gly-betatrif


2608:ibhs-nme35pyr-gly-betahmph


2609: phhs-25oxaz-bala-betacbph


2610: tolhs-25thiaz-gly-asppha


2611: bhs-25thiaz-bala-betahc


2612: tolhs-25thiaz-gly-betaph


2613:bhs-ithiadiaz-gly-zdapee


2614: bhs-25oxaz-bala-betamesu


2615: bhs-nme35pyr-gly-betahc


2616: tolhs-me25thiaz-gly-betapy


2617: bhs-oxadiaz-bala-betafph


2618:bim-nme35pyr-leu-betadcph


2619: tolhs-nme35pyr-bala-betamesu


2620: dhim-25thiaz-gly-betameph


2621: tolhs-me25thioph-ala-betapy


2622: ibhs-oxadiaz-bala-betaamibe


2623:impy-24thiaz-gly-betabthioph


2624: ibhs-25oxaz-bala-betaph


2625: bhs-25methiaz-gly-betapych




CA 02371604 2001-10-24
WO 0016661$ PCTIEP00103469
_97_
2626:bhs-25methiaz-gly-betambiph


2627:tolhs-25oxaz-gly-betadtrif


2628:bhs-25methiaz-nmgly-betadmph


2629:bhs-25thiaz-ala-betabpy


2630:ibhs-25oxaz-gly-betacthioph


2631:2py-24thioph-gly-betacthioph


2632:bhs-24thioph-gly-betadcphee


2633:ibhs-25oxaz-gly-betadbph


2634:phhs-24thiaz-gly-betapym


2635:tolhs-nme35pyr-bala-betathiome


2636:bhs-ithiadiaz-ala-betadmph


2637:bhs-25thiaz-bala-betahmo


2638:bhs-25methiaz-nmgly-betahph


2639:tolhs-nme35pyr-gly-betameph


2640:ibhs-25methiaz-gly-betaomebendi


2641:bim-25oxaz-bala-beta4bph


2642:2py-24thiaz-gly-betainyl


2643:bhs-ithiadiaz-bala-betaipr


2644:bhs-25thiaz-bala-betahdbph


2645:ibhs-25oxaz-gly-betahcbph


2646:tolhs-24thiaz-bala-betaibph


2647:2py-25fur-gly-psdap


2648:phhs-25thiaz-bala-betaph


2649:bhs-24thiaz-gly-betapy


2650:ibhs-nme35pyr-bala-betabthioph


2651:tolhs-ithiadiaz-gly-betainyl


2652:dhpyrr-42nmeim-gly-zdap


2653:bhs-nme35pyr-gly-csdap


2654:gua-25thiaz-gly-betatos


2655:bhs-24thioph-gly-betatbuph


2656:ibhs-25oxaz-bala-betatbuph


2657:bhs-25thiaz-bala-betabenfu


2658:ibhs-nme35pyr-gly-betapy


2659:2py-26py-gly-ibsdap


2660:2py-24thiaz-bala-aspibua


2661:bhs-oxadiaz-gly-betabediox


2662:phhs-nme35pyr-bala-betafu2




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
_98_
2663:bhs-thiadiaz-ala-betadcph


2664;bhs-oxadiaz-bala-betaheph


2665;bhs-25thiaz-gly-beta34meoph


2666:bhs-25methiaz-bala-betadmph


2667:bhs-25thiaz-bala-betaftrif


2668:ibhs-24oxaz-gly-zdap


2669:tolhs-ithiadiaz-bala-betah35dc


2670:2py-24thiaz-bala-betafluo


2671:agua-24thiaz-gly-betainyl


2672:bim-25methiaz-bala-aspaba


2673:bhs-25thiaz-gly-betahmph


2674:phhs-25thiaz-bala-betaet


2675:bhs-25thiaz-bala-psdapch


2676:phhs-oxadiaz-gly-betadcph


2677:2py-42nmeim-nmala-betapy


2678:ibhs-26py-gly-betainyl


2679:phhs-25methiaz-gly-ibsdap


2680:bim-42pym-ala-psdap


2681:phhs-24thiaz-bala-betahph


2682:tolhs-24thioph-gly-betabdimo


2683:ibhs-25oxaz-bala-betatrif


2684:bhs-nme35pyr-ala-zdap


2685:bhs-25fur-bala-betapy


2686:phhs-24thioph-gly-betabnaphth


2687:tolhs-nme35pyr-bala-betathioph


2688:phhs-25methiaz-bala-betaamibe


2689:tolhs-24thiaz-bala-betafbph


2690:ibhs-oxadiaz-gly-psdaptb


2691:tolhs-nme35pyr-gly-suabu


2692:tolhs-25methiaz-gly-betabnaphth


2693:bhs-25oxaz-mngly-betabnaphth


2694:ibhs-25thiaz-bala-betapytb


2695:tolhs-nme35pyr-bala-psdapee


2696:2py-24thioph-gly-betadcph


2697:sabhs-25thiaz-ala-betameph


2698:bhs-25methiaz-gly-betathio3


2699:ibhs-25methiaz-gly-psdaptb




CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
_99_
2700:bhs-nme35pyr-gly-betapym


2701:ibhs-25thiaz-gly-ibsdap


2702:impy-25methiaz-bala-betaftrif


2703:tolhs-25methiaz-gly-betafluo


2704:ibhs-25oxaz-bala-betaoxope


2705:gua-26py-gly-betafbph


2706:bhs-nme35pyr-bala-betahb


2707:ibhs-nme35pyr-bala-betapyee


2708:bhs-24oxaz-bala-psdap


2709:bhs-25oxaz-bala-betahdbph


2710:phhs-25oxaz-bala-zdap


2711:phhs-25methiaz-gly-betah35dc


2712:ibhs-25thiaz-bala-betacph


2713:tolhs-25thiaz-gly-betaamibe


2714:bhs-ithiadiaz-bala-betahmo


2715:tolhs-24thiaz-gly-suabu


2716:phhs-nme35pyr-gly-betaol


2717:phhs-24thiaz-bala-betapbiph


2718:bhs-oxadiaz-nmgly-betadito


2719:tolhs-ithiadiaz-gly-betaanaphth


2720:tolhs-25thiaz-gly-busu2be


2721:bim-24im-ala-betadcph


2722:ibhs-25thiaz-gly-betahmofu


2723:tolhs-oxadiaz-bala-betaomebendi


2724:bhs-ithiadiaz-gly-betadtrif


2725:ibhs-25methiaz-gly-betathioph


2726:phhs-25methiaz-bala-betahdbph


2727:bhs-nme35pyr-bala-betaol


2728:gua-26py-gly-betahc


2729:ibhs-25oxaz-bala-beta34meoph


2730:bim-25methiaz-bala-betahcbph


2731:phhs-nme35pyr-bala-betafph


2732:tolhs-25oxaz-bala-betaet


2733:2py-nme35pyr-gly-betadcph


2734:tolhs-oxadiaz-gly-betaol


2735:bhs-24im-ala-zdap


2736:2py-35thioph-gly-betadcph




CA 02371604 2001-10-24
WO 00166618 PCT/EPOO103469
- 100
2737:tolhs-25methiaz-gly-psdapee


2738:impy-25methiaz-bala-psdap


2739:ibhs-25methiaz-bala-betabediox


2740:tolhs-nme35pyr-bala-betaphethioa


2741:tolhs-ithiadiaz-gly-betahbcph


2742:thazep-24thioph-bala-zdap


2743:dhim-25py-gly-betameph


2744:2py-25fur-gly-betapy


2745:impy-42nmeim-gly-betabmph


2746:tolhs-24thioph-gly-betacbph


2747:phhs-oxadiaz-bala-betaftrif


2748:tolhs-25thiaz-bala-betacph


2749:phhs-24thiaz-bala-betadito


2750:bhs-25fur-ala-betapy


2751:ibhs=25oxaz-gly-betahb


2752:tolhs-24thiaz-bala-zdapee


2753:bhs-25oxaz-gly-betahmo


2754:gua-24thiaz-gly-betamethioph


2755:nmhs-24thiaz-gly-betapy


2756:phhs-25thiaz-gly-betafph


2757:tolhs-25oxaz-gly-betadmoph


2758:phhs-oxadiaz-bala-betaet


2759:bhs-24thiaz-gly-psdapee


2760:ibhs-24thiaz-bala-betabediox


2761:gua-24thiaz-gly-betafu3


2762:tolhs-nme35pyr-bala-betaphethio


2763:ibhs-24thioph-gly-psdap


2764:tolhs-me24oxaz-leu-beta34meoph


2765:2py-24thioph-bala-aspaba


2766:bim-me24oxaz-leu-psdap


2767:bhs-nme35pyr-bala-betamesu


2768:bhs-thiadiaz-gly-zdap


2769:2py-oxadiaz-ala-zdap


2770:bim-25methiaz-gly-betapbiph


2771:ibhs-24thioph-gly-betadcphee


2772:tolhs-nme35pyr-bala-betahdcph


2773:bhs-me24thioph-gly-betadcph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-101
2774:phhs-25thiaz-bala-zdapch


2775:bhs-25thiaz-gly-betapych


2776:bhs-ithiadiaz-bala-betahdbph


2777:impy-24thiaz-nmgly-psdap


2778:bim-25oxaz-bala-beta13bendi


2779:bim-oxadiaz-bala-betapy


2780:tolhs-24thiaz-bala-betahdcph


2781:2py-nme35pyr-ala-psdap


2782:ibhs-25thiaz-gly-betadtrif


2783:phhs-25thiaz-gly-betahbcph


2784:ibhs-oxadiaz-bala-zdapch


2785:dhim-26py-hphe-zdap


2786:phhs-nme35pyr-gly-betahbcph


2787:bhs-25thiaz-bala-betafluo


2788:ibhs-oxadiaz-gly-beta3quin


2789:2py-35fur-bala-betadcph


2790:2py-me25oxaz-gly-betadcph


2791:bhs-24thiaz-gly-betaipr


2792:bhs-25methiaz-bala-betabediox


2793:ibhs-ithiadiaz-gly-betaph


2794:phhs-25thiaz-bala-aspibua


2795:tolhs-oxadiaz-bala-betabdimo


2796:2py-me24thiaz-ala-betapy


2797:impy-25methiaz-ala-betapy


2798:phhs-nme35pyr-bala-betabnaphth


2799:bim-me25oxaz-leu-betapy


2800:gua-me24thiaz-gly-betapy


2801:2py-24im-gly-betapy


2802:bhs-25thiaz-bala-betapbiph


2803:bhs-24thioph-bala-ibsdap


2804:2py-35thioph-leu-betapy


2805:bhs-25thiaz-ala-beta3quin


2806:ibhs-24thioph-bala-csdap


2807:bhs-53pyrazo-bala-zdap


2808:bhs-42nmeim-gly-betapy


2809:phhs-25oxaz-gly-betathioph


2810:ibhs-25methiaz-gly-betabpy




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-102
2811:ibhs-24thiaz-bala-betapyee


2812:bhs-25thiaz-nmgly-betaipro


2813:bhs-25methiaz-bala-betampy


2814:bhs-24thioph-bala-betamesu


2815:bim-me24oxaz-bala-zdap


2816:bhs-25methiaz-gly-betaph


2817:bim-25thiaz-gly-zdap


2818:bhs-nme35pyr-gly-betatbuph


2819:bhs-25oxaz-ala-betadhbfu


2820:ibhs-ithiadiaz-bala-betaphethioa


2821:bhs-oxadiaz-g1y-betathiome


2822:phhs-24thioph-bala-betabediox


2823:bhs-25thiaz-bala-betathioph


2824:phhs-oxadiaz-bala-betaipr


2825:bim-me25thioph-gly-betadcph


2826:bhs-25oxaz-gly-betameph


2827:bhs-oxadiaz-gly-beta13bendi


2828:ibhs-oxadiaz-gly-zdapee


2829:2py-me24thioph-bala-psdap


2830:bhs-25thiaz-bala-betacbph


2831:2py-me25oxaz-leu-betadcph


2832:tolhs-25thiaz-bala-betahcbph


2833:ibhs-25oxaz-bala-betabdimo


2834:2py-25thioph-ala-betainyl


2835:bhs-oxadiaz-bala-betathioph


2836:bhs-25methiaz-gly-betaipro


2837:bhs-24thioph-ala-betapy


2838:ibhs-25thiaz-gly-betafluo


2839:2py-24oxaz-gly-zdap


2840:phhs-oxadiaz-bala-betadcphee


2841:2py-24thiaz-ala-betadcph


2842:ibhs-24thiaz-gly-betaheph


2843:bhs-me25oxaz-ala-betapy


2844:ibhs-nme35pyr-bala-betaomebendi


2845:bhs-thiadiaz-gly-betapy


2846:bhs-25thiaz-gly-betadhbfu


2847:dhim-24oxaz-gly-betapy




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-103
2848:gua-24thiaz-gly-betafluo


2849:bhs-thiadiaz-bala-zdap


2850:ibhs-25oxaz-gly-betahni


2851:tolhs-25thiaz-bala-betahc


2852:bhs-nme35pyr-ala-ibsdap


2853:bhs-oxadiaz-gly-betabdimo


2854:phhs-me24thiaz-leu-betaph


2855;tolhs-25thiaz-bala-betathioph


2856:bhs-25oxaz-bala-betatrif


2857:ibhs-24thiaz-gly-betamesu


2858:bim-25thiaz-ala-betainyl


2859:bhs-me25thiaz-leu-zdap


2860:tolhs-me24thiaz-bala-betadcph


2861:ibhs-25oxaz-gly-betacph


2862:bim-26py-ala-zdap


2863:bhs-oxadiaz-nmgly-betacph


2864:ibhs-25methiaz-gly-beta3quin


2865:2py-me25thiaz-gly-zdap


2866:2pmhs-24thioph-bala-betahph


2867:impy-25methiaz-bala-betafu3


2868:phhs-nme35pyr-gly-betamesu


2869:ibhs-oxadiaz-gly-betaphethioa


2870:tolhs-24thioph-bala-betathioph


2871:ibhs-25oxaz-gly-psdaptb


2872:bim-25methiaz-gly-betapy


2873:2py-25oxaz-ala-zdap


2874:phhs-24thiaz-gly-betadtrif


2875:bhs-oxadiaz-bala-betacthioph


2876:2py-nme35pyr-gly-aspbzla


2877:ibhs-25oxaz-gly-betafu2


2878:ibhs-24thioph-bala-betahb


2879:bim-me25oxaz-bala-zdap


2880:bim-42nmeim-bala-beta34meoph


2881:bim-me24thiaz-gly-betapy


2882:phhs-25methiaz-gly-csdap


2883:bhs-ithiadiaz-gly-betapym


2884:phhs-24thioph-bala-betacbph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 104
2885:bhs-25oxaz-gly-betafu3


2886:2py-24im-leu-psdap


2887:bhs-me25thioph-ala-betadcph


2888:tolhs-25thiaz-gly-betadcphee


2889:bhs-25oxaz-bala-ibsdap


2890:2py-me24thiaz-bala-zdap


2891:bhs-me25thioph-gly-betaph


2892:phhs-nme35pyr-bala-betaet


2893:bim-24thiaz-gly-betaanaphth


2894:bhs-24thiaz-ala-betathioph


2895:bhs-53pyrazo-leu-zdap


2896:2py-42nmeim-bala-betahmph


2897:2py-me25oxaz-gly-betapy


2898:tolhs-24thioph-gly-betamethi


2899:bhs-24thioph-bala-betadbph


2900:ibhs-25thiaz-gly-beta35dbph


2901:phhs-24thioph-bala-aspbzla


2902:tolhs-24thioph-bala-beta35dbph


2903:bhs-nme35pyr-baia-betaipr


2904:bim-me24thiaz-bala-beta34meoph


2905:ibhs-24thioph-gly-betamesu


2906:2py-me25thioph-gly-betaph


2907:dhim-25thioph-ala-psdap


2908:impy-24thiaz-ala-betapy


2909:tolhs-nme35pyr-gly-betahbcph


2910:tolhs-oxadiaz-gly-betacthioph


2911:bhs-nme35pyr-gly-betahph


2912:tolhs-25oxaz-gly-betaipro


2913:phhs-25vxaz-bala-betahni


2914:ibhs-25methiaz-bala-csdap


2915:2py-25thiaz-ala-psdap


2916:tolhs-me24oxaz-gly-psdap


2917:ibhs-ithiadiaz-gly-betaftrif


2918:phhs-nme35pyr-gly-betadtrif


2919:2pmhs-25methiaz-bala-beta13bendi


2920:bhs-oxadiaz-nmgly-beta34dcph


2921:bim-25thiaz-bala-betaipro




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 105
2922:phhs-oxadiaz-gly-betabthioph


2923:bhs-24thioph-gly-betahmo


2924:phhs-24thioph-bala-betahmofu


2925:tolhs-me24thiaz-leu-betaph


2926:tolhs-25thiaz-bala-betahbcph


2927:ibhs-ithiadiaz-gly-beta13bendi


2928:tolhs-ithiadiaz-gly-suabu


2929:bim-26py-ala-betapy


2930:ibhs-24thioph-bala-betacthioph


102931:ibhs-25thiaz-gly-betaet


2932:phhs-nme35pyr-gly-betaoxope


2933:bim-35fur-gly-betapy


2934:phhs-oxadiaz-gly-betafu2


2935:bhs-52thiaz-ala-betadcph


152936:tolhs-25methiaz-bala-betahmph


2937:ibhs-25thiaz-bala-betaftrif


2938:tolhs-oxadiaz-bala-zdap


2939:bim-me25thioph-ala-beta34meoph


2940:gua-42pym-gly-beta35dbph


202941:gua-26py-gly-betabpy


2942:4pmhs-25thiaz-gly-zdap


2943:tolhs-oxadiaz-gly-betaphethioa


2944:tolhs-nme35pyr-gly-betatbuph


2945:gua-26py-gly-betahbcph


25294fi:bhs-25thiaz-bala-betacthioph


2947:ibhs-24thioph-bala-suabu


2948:ibhs-24thiaz-gly-betacph


2949:ibhs-nme35pyr-gly-betaftrif


2950:2py-me25thiaz-gly-betadcph


302951:2py-24oxaz-ala-zdap


2952:agua-24thiaz-gly-betadcph


2953:impy-42nmeim-bala-betahb


2954:bhs-25oxaz-bala-betabdimo


2955:phhs-nme35pyr-bala-zdap


352956:bhs-me24thiaz-leu-zdap


2957:tolhs-24thiaz-bala-beta23meoph


2958:bhs-triaz-gly-betameph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-106-
2959:bhs-ithiadiaz-gly-betathio3


2960:ibhs-nme35pyr-bala-betafph


2961:gua-24thiaz-gly-betahni


2962:bhs-25thiaz-nmgly-betacthioph


2963:tolhs-25oxaz-bala-betadcphch


2964:phhs-25thiaz-bala-betafu3


2965:tolhs-ithiadiaz-bala-zdaptb


2966:ibhs-ithiadiaz-gly-betaipro


2967:bhs-25oxaz-ala-betaoxaz
'


2968:phhs-ithiadiaz-gly-betaipr


2969:bhs-nme35pyr-bafa-betabenfu


2970:2py-52thiaz-ala-psdap


2971:bhs-24thioph-gly-betabpy


2972:dhthi-25methiaz-bala-betadcph


2973:ibhs-24thioph-gly-betaomebendi


2974:tolhs-nme35pyr-gly-betadcphch


2975:bhs-25thiaz-bala-betaanaphth


2976:bhs-25methiaz-ala-betaoxaz


2977:tolhs-25methiaz-bala-betadmph


2978:2py-42nmeim-gly-betadcph


2979:bhs-35thioph-gly-betadcph


2980:phhs-nme35pyr-bala-betahmofu


2981:ibhs-25methiaz-gly-betahmph


2982:tolhs-ithiadiaz-gly-betapym


2983:bhs-ithiadiaz-gly-betadcphee


2984:bim-53pyrazo-bala-betadcph


2985:tolhs-25oxaz-bala-betabph


2986:ibhs-25oxaz-giy-betahph


2987:tolhs-25oxaz-gly-betampy


2988:ibhs-oxadiaz-bala-zdaptb


2989:bhs-oxadiaz-bala-betafbph


2990:tolhs-25oxaz-gly-betaipr


2991:bim-me24thioph-bala-beta34meoph


2992:bhs-42pym-gly-betadcph


2993:phhs-25methiaz-bala-betadtrif


2994:2py-25oxaz-gly-betaipr


2995:phhs-oxadiaz-bala-betacbph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 107
2996:ibhs-24thioph-gly-betaoxaz


2997:tolhs-ithiadiaz-gly-betaftrif


2998:bhs-nme35pyr-nmgly-betaoxaz


2999:bhs-25thiaz-ala-betabnapbth


3000:phhs-24thioph-gly-betacbph


3001:bhs-me25thioph-leu-betapy


3002:bhs-me24thiaz-ala-betadcph


3003:ibhs-25thiaz-bala-betaol


3004:ibhs-25methiaz-gly-betabediox


103005:phhs-25thiaz-gly-betaipr


3006:bim-24oxaz-bala-zdap


3007:bhs-25oxaz-bala-zdapch


3008:3pmhs-25thiaz-bala-betapy


3009:tolhs-25methiaz-bala-betafluo


153010:bhs-ithiadiaz-gly-betapbiph


3011:phhs-24thiaz-gly-beta23meoph


3012:bhs-nme35pyr-gly-betadhbfu


3013:ibhs-25oxaz-bala-aspaba


3014:thpym-24thiaz-gly-betadcph


203015:bhs-oxadiaz-gly-betafbph


3016:2py-25thiaz-leu-psdap


3017:2py-53pyrazo-ala-psdap


3018:ibhs-nme35pyr-bala-beta23meoph


3019:tolhs-24thioph-gly-betahni


253020:ibhs-24thioph-gly-betamethioph


3021:bhs-25methiaz-bala-betahc


3022:phhs-oxadiaz-bala-betamethioph


3023:ibhs-25methiaz-bala-aspaba


3024:bim-24thioph-gly-betaomebendi


303025:tolhs-ithiadiaz-gly-betapytb


3026:bim-25methiaz-gly-betatrif


3027:2py-me25thiaz-gly-betaph


3028:phhs-25oxaz-bala-betabpy


3029:phhs-nme35pyr-gly-betahph


353030:tolhs-ithiadiaz-gly-betabmph


3031:tolhs-25methiaz-gly-betahni


3032:phhs-25methiaz-bala-betaomebendi




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 108
3033:tolhs-oxadiaz-gly-betamethi


3034:ibhs-24thiaz-bala-csdap


3035:ibhs-ithiadiaz-gly-betaomebendi


3036:tolhs-oxadiaz-bala-betamesu


3037:bhs-24thioph-gly-psdapch


3038:phhs-24thioph-gly-zdap


3039:2py-25oxaz-bala-psdap


3040:bhs-me24thiaz-ala-betapy


3041:tolhs-24thioph-bala-beta34dcph


3042:2py-25thioph-leu-betadcph


3043:bhs-25methiaz-gly-betafluo


3044:tolhs-25oxaz-gly-betahmph


3045:tolhs-nme35pyr-bala-betacbph


3046:ibhs-25thiaz-bala-betahni


3047:sabhs-25methiaz-gly-psdap


3048:ibhs-ithiadiaz-gly-zdapee


3049:ibhs-nme35pyr-gly-betafph


3050:bim-25thioph-bala-betadcph


3051:phhs-25oxaz-bala-betahph


3052:phhs-nme35pyr-bala-aspaba


3053:ibhs-24thioph-gly-beta4bph


3054:bhs-25thiaz-gly-betatrif


3055:bhs-25thiaz-bala-betathio3


3056:tolhs-ithiadiaz-gly-betathio3


3057:tolhs-ithiadiaz-bala-zdap


3058:bim-24thiaz-bala-betatos


3059:tolhs-25oxaz-gly-suabu


3060:bhs-24thioph-bala-betapbiph


3061:ibhs-oxadiaz-bala-betabnaphth


3062:bim-42nmeim-gly-zdap


3063:phhs-me25thiaz-leu-betapy


3064:bhs-25methiaz-gly-betamesu


3065:bhs-me25thiaz-gly-psdap


3066:tolhs-me25oxaz-bala-zdap


3067:bim-53pyrazo-ala-betapy


3068:phhs-ithiadiaz-bala-beta34dcph


3069:ibhs-25thiaz-gly-betapyee




CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-109
3070: tolhs-25thiaz-bala-betaoxope


3071: ibhs-25methiaz-gly-betampy


3072: tolhs-24thiaz-gly-betaoxope


3073: bhs-oxadiaz-gly-beta34meoph


3074: tolhs-ithiadiaz-bala-betaoxaz


3075: phhs-24thioph-gly-betadcphch


3076: 2py-me24thiaz-bala-psdap


3077: bhs-25thiaz-ala-betainyl


3078: phhs-25thiaz-gly-betahdcph


3079:phhs-25thiaz-gly-betah35dc


3080: tolhs-25methiaz-gly-betathio3


3081: 2py-me24thioph-gly-betaph


3082: bhs-24thioph-bala-betaoxope


3083: bhs-24thiaz-bala-aspbzla


3084:phhs-25thiaz-bala-betamethioph


3085: tolhs-25thiaz-bala-betadcphee


3086: bhs-24thioph-feu-betadcph


3087: ibhs-24thioph-gly-ibsdap


3088: phhs-nme35pyr-gly-betaibph


3089:phhs-25thiaz-bala-betahdbph


3090: bgua-24thiaz-gly-psdap


3091: bhs-25oxaz-gly-betadcph


3092: phhs-nme35pyr-bala-betaol


3093: tolhs-ithiadiaz-bala-betaibph


3094:phhs-25thiaz-bala-betacph


3095: ibhs-nme35pyr-bala-betabediox


3096: tolhs-ithiadiaz-gly-betapych


3097: bhs-nme35pyr-gly-psdap


3098: phhs-25thiaz-gly-betahb


3099:phhs-24thiaz-gly-betafu2


3100: tolhs-ithiadiaz-bala-betadcph


3101: ibhs-25oxaz-gly-betabph


3102: gua-24oxaz-gly-betapym


3103: tolhs-25thiaz-bala-betabediox


3104:bim-thiadiaz-bala-psdap


3105: tolhs-24thiaz-bala-betamethi


3106: bhs-24thioph-gly-betaol




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 110
3107: bim-25thioph-bala-psdap


3108: tolhs-25oxaz-gly-aspbzla


3109: tolhs-24thioph-bala-betaamibe


3110: bhs-me24thiaz-gly-betapy


3111: ibhs-oxadiaz-bala-betadmoph


3112: tolhs-25thiaz-bala-betabmph


3113: phhs-25thiaz-bala-betabmph


3114: phhs-25oxaz-bala-beta34meoph


3115: phhs-25methiaz-gly-asppha


103116: bhs-25methiaz-bala-betatrif


3117: bim-me24thiaz-leu-psdap


3118: ibhs-25thiaz-gly-betabdimo


3119: gua-25oxaz-gly-zdap


3120: bhs-25oxaz-gly-betahmph


153121: bim-42pym-gly-betapy


3122: ibhs-25thiaz-gly-psdaptb


3123: bhs-25oxaz-bala-beta4bph


3124: bhs-ithiadiaz-gly-betahcbph


3125: ibhs-25thiaz-bala-zdapch


203126: ibhs-nme35pyr-bala-busu2be


3127: bhs-24oxaz-ala-betadcph


3128: bhs-25methiaz-gly-betapyee


3129: ibhs-24thiaz-bala-betabph


3130: phhs-ithiadiaz-bala-betabnaphth


253131: ibhs-ithiadiaz-bala-zdapch


3132: bhs-nme35pyr-nmgly-betaipro


3133: bhs-25thiaz-bala-csdap


3134: tolhs-ithiadiaz-bala-betathiobe


3135: bhs-24thiaz-gly-betadcph


303136: dhim-25thiaz-gly-betadcph


3137: tolhs-25oxaz-bala-betatrif


3138: impy-24thioph-ala-betapy


3139: phhs-25methiaz-gly-betathio3


3140: gua-24thiaz-gly-betapyr


353141: impy-24thiaz-bala-betaftrif


3142: phhs-nme35pyr-bala-betahni


3143: 2py-42nmeim-bala-psdap




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 111
3144: ibhs-25thiaz-bala-asppha


3145: phhs-24thioph-bala-psdapch


3146: tolhs-24thiaz-gly-betadmph


3147: bim-24thiaz-gly-betadbph


3148: bhs-42pym-gly-betapy


3149: phhs-25methiaz-bala-betafluo


3150: 2py-35thioph-ala-zdap


3151: tolhs-24thiaz-bala-betaoxaz


3152: phhs-24thioph-bala-betatos


3153:tolhs-oxadiaz-bala-beta23meoph


3154: bhs-ithiadiaz-nmgly-betabpy


3155: tolhs-nme35pyr-bala-betameph


3156: tolhs-ithiadiaz-gly-betacph


3157: bhs-24oxaz-ala-betapy


3158:2py-24thioph-bala-zdap


3159: bim-25thiaz-bala-betahcbph


3160: phhs-25thiaz-gly-betathiobe


3161: bhs-24thioph-bala-busu2be


3162: phhs-me25oxaz-bala-psdap


3163:phhs-25thiaz-gly-betatos


3164: bhs-25thiaz-nmgly-betabnaphth


3165: tolhs-24thioph-gly-betadcphtb


3166: ibhs-ithiadiaz-gly-betacph


3167: phhs-ithiadiaz-bala-betahph


3168:ibhs-ithiadiaz-bala-betaet


3169: phhs-25methiaz-bala-ibsdap


3170: tolhs-25methiaz-gly-betahdcph


3171: ibhs-25oxaz-bala-betahmofu


3172: bhs-24thioph-gly-betahmofu


3173:2py-me25oxaz-bala-betadcph


3174: bhs-nme35pyr-bala-betacthioph


3175: ibhs-24thioph-bala-betaipro


3176: bim-25methiaz-gly-betahmph


3177: sabhs-26py-gly-betainyl


3178:phhs-ithiadiaz-gly-psdapch


3179: bim-me25oxaz-bala-betaph


3180: phhs-oxadiaz-bala-betaphethioa




CA 02371604 2001-10-24
WO 00166618 PCTIEPOOI03469
-112
3181:tolhs-ithiadiaz-bala-betainyl


3182:bhs-24thioph-nmgly-betadhbfu


3183:phhs-25methiaz-gly-betaol


3184:phhs-ithiadiaz-bala-betabph


3185:2py-me25thioph-ala-zdap


3186:bim-ithiadiaz-bala-aspaba


3187:dhim-26py-nmgly-zdap


3188:2py-24thioph-ala-betapy


3189:tolhs-25oxaz-gly-betafu3


3190:tolhs-25oxaz-bala-betahdcph


3191:bhs-ithiadiaz-gly-betatbuph


3192:2py-25methiaz-bala-betahni


3193:bhs-24thiaz-ala-betaipro


3194:bhs-24thiaz-gly-aspaba


3195:ibhs-nme35pyr-bala-aspibua


3196:bhs-25methiaz-bala-betabmph


3197:bhs-25methiaz-ala-betamesu


3198:bhs-nme35pyr-bala-betadcph


3199:impy-42nmeim-bala-betapy


3200:ibhs-25methiaz-bala-betadbph


3201:ibhs-ithiadiaz-bala-asppha


3202:tolhs-25methiaz-bala-betatrif


3203:ibhs-ithiadiaz-bala-betapym


3204:bhs-nme35pyr-nmgly-betathioph


3205:tolhs-me25oxaz-bala-psdap


3206:tolhs-24thioph-bala-betatbuph


3207:bhs-ithiadiaz-bala-busu2be


3208:tolhs-oxadiaz-bala-aspibua


3209:phhs-ithiadiaz-gly-betafphe


3210:ibhs-25methiaz-gly-betahdbph


3211:bhs-me24oxaz-gly-psdap


3212:bhs-46pym-a1a-zdap


3213:bim-25thioph-ala-betainyl


3214:phhs-24thioph-gly-betampy


3215:gua-26py-gly-betaftrif


3216:ibhs-25thiaz-bala-betabmph


3217:ibhs-oxadiaz-gly-betadcph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 113
3218:2pmhs-25methiaz-bala-betabmph


3219:bim-ithiadiaz-gly-asppha


3220:phhs-25methiaz-gly-beta34dcph


3221:tolhs-24thioph-gly-betahcbph


3222:bhs-ithiadiaz-nmgly-betafphe


3223:ibhs-ithiadiaz-gly-betaphethio


3224:phhs-25oxaz-bala-zdapch


3225:ibhs-oxadiaz-gly-betamesu


3226:tolhs-oxadiaz-bala-betadcphee


3227:tolhs-ithiadiaz-gly-aspaba


3228:impy-24thioph-bala-busu2be


3229:bhs-24thioph-leu-zdap


3230:ibhs-oxadiaz-bala-betaftrif


3231:gua-26py-gly-betapbiph


3232:ibhs-oxadiaz-gly-betapytb


3233:bim-25fur-gly-betadcph


3234:bhs-24thiaz-gly-psdaptb


3235:ibhs-ithadiaz-gly-beta34meoph


3236:tolhs-25thiaz-bala-betadcphch


3237:phhs-24thioph-bala-betahb


3238:2py-25thiaz-gly-psdap


3239:tolhs-24thiaz-gly-betahdbph


3240:ibhs-nme35pyr-gly-psdap


3241:bhs-25thiaz-leu-betameph


3242:bhs-25thiaz-bala-betafphe


3243:ibhs-oxadiaz-gly-beta34meoph


3244:phhs-me24oxaz-ala-zdap


3245:ibhs-ithiadiaz-gly-betabpy


3246:bhs-ithiadiaz-gly-betamethi


3247:phhs-25thiaz-bala-csdap


3248:bhs-25thiaz-met-betadcph


3249:2py-nme35pyr-bala-psdap


3250:bhs-25thiaz-gly-betatos


3251:bhs-25oxaz-gly-betaomebendi


3252:bhs-24thiaz-gly-betapyee


3253:ibhs-oxadiaz-bala-betafphe


3254:gua-24thiaz-nmgly-betapy




CA 02371604 2001-10-24
WO 00!66618 PCTIEPOOl03469
- 114 -
3255:ibhs-24thiaz-bala-psdapee


3256:2py-25methiaz-bala-aspaba


3257:ibhs-25thiaz-gly-betabediox


3258:phhs-me24thiaz-leu-beta34meoph


3259:ibhs-25methiaz-bala-betabthioph


3260:ibhs-25oxaz-gly-betapych


3261:2py-52thiaz-ala-betainyl


3262:tolhs-me24thioph-ala-zdap


3263:ibhs-24thioph-gly-betabmph


3264:bhs-25thiaz-gly-zdaptb


3265:phhs-24thioph-bala-ibsdap


3266:bhs-nme35pyr-gly-betahni


3267:bhs-25oxaz-gly-zdapch


3268:phhs-25oxaz-gly-betafu3


3269:phhs-25thiaz-bala-betadmoph


3270:bhs-oxadiaz-nmgly-betadmoph


3271:bhs-25methiaz-gly-betahbcph


3272:tolhs-25methiaz-bala-betabthioph


3273:bhs-oxadiaz-bala-zdapch


3274:gua-24oxaz-gly-betaamibe


3275:phhs-25thiaz-gly-betabpy


3276:bhs-24im-bala-psdap


3277:phhs-24thiaz-bala-asppha


3278:ibhs-ithiadiaz-gly-betadmoph


3279:tolhs-24thioph-bala-suabu


3280:bim-me24oxaz-bala-betadcph


3281:tolhs-oxadiaz-bala-betabph


3282:phhs-24thiaz-bala-betaipro


3283:bhs-oxadiaz-bala-betaipro


3284:phhs-25oxaz-bala-betadtrif


3285:ibhs-25oxaz-gly-betambiph


3286:bhs-nme35pyr-gly-aspibua


3287;bim-oxadiaz-leu-betapy


3288:bhs-oxadiaz-ala-betaanaphth


3289:2py-25thiaz-ala-betainyl


3290:2py-24thiaz-bala-suabu


3291:bhs-24thiaz-bala-betahni




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-115
3292:bhs-25methiaz-ser-betapy


3293:phhs-oxadiaz-gly-betaheph


3294.gua-24thiaz-gly-suabu


3295:tolhs-25methiaz-bala-betacph


3296:ibhs-25thiaz-gly-betapy


3297:ibhs-24thioph-bala-betatos


3298:thpym-24thiaz-gly-betahdcph


3299:tolhs-25methiaz-bala-aspibua


3300:thazep-25oxaz-gly-psdap


3301:tolhs-nme35pyr-bala-zdapch


3302:bhs-oxadiaz-gly-betaphethioa


3303:phhs-me24thioph-leu-betaph


3304:phhs-me25oxaz-gly-psdap


3305:tolhs-25methiaz-gly-betamethi


3306:ibhs-25oxaz-bala-betacbph


3307:bhs-25thiaz-leu-betapy


3308:ibhs-ithiadiaz-gly-betahdcph


3309:they-24oxaz-gly-betadcph


3310:phhs-25thiaz-bala-betathioph


3311:bim-ithiadiaz-gly-aspaba


3312:tolhs-ithiadiaz-bala-aspbzla


3313:bim-24thioph-ala-zdap


3314:ibhs-25oxaz-gly-betapyr


3315:bhs-24thioph-gly-betaipro


3316:bhs-24thiaz-bala-betaoxope


3317:bhs-nme35pyr-gly-betah35dc


3318:phhs-oxadiaz-bala-betapym


3319:tolhs-24thiaz-bala-betaheph


3320:ibhs-ithiadiaz-gly-betaheph


3321:phhs-24thioph-gly-betaomebendi


3322:ibhs-ithiadiaz-bala-betacthioph


3323:bhs-ithiadiaz-gly-betamesu


3324:nmhs-24thioph-gly-betadcph


3325:ibhs-24thiaz-bala-betatrif


3326:bhs-oxadiaz-bala-betambiph


3327:bhs-oxadiaz-nmgly-betaipro


3328:bim-me24thioph-leu-beta34meoph




CA 02371604 2001-10-24
WO 00!66618 PCTlEP00/03469
- 116 -
3329:2pmhs-24thiaz-gly-betahbcph


3330:tolhs-24thiaz-gly-betapy


3331:ibhs-25oxaz-bala-betathiobe


3332:2pmhs-42pym-gly-betapy


3333:phhs-25methiaz-bala-betaph


3334:phhs-oxadiaz-gly-betafphe


3335:tolhs-ithiadiaz-gly-betahmo


3336:bhs-25oxaz-nmgly-betathioph


3337;bhs-42nmeim-gly-suabu


3338:ibhs-24thiaz-bala-betah35dc


3339;bgua-24thioph-gly-betameph


3340:phhs-ithiadiaz-gly-betatos


3341:tolhs-oxadiaz-giy-beta34dcph


3342:ibhs-25methiaz-bala-betaheph


3343:bim-25fur-ala-zdap


3344:bim-24thioph-bala-betadcph


3345:ibhs-25oxaz-bala-betaftrif


3346:ibhs-oxadiaz-gly-beta34dcph


3347:tolhs-25thiaz-gly-betamesu


3348:bhs-oxadiaz-bala-betapy


3349:impy-24thioph-bala-betaphethioa


3350:ibhs-24thioph-giy-betadcph


3351:bhs-ithiadiaz-gly-aspibua


3352:bhs-24oxaz-bala-zdap


3353:tolhs-25thiaz-gly-betapytb


3354:phhs-oxadiaz-bala-betabenfu


3355:tolhs-24thiaz-bala-betahcbph


3356:bim-25thiaz-bala-betacph


3357:ibhs-25methiaz-bala-betatbuph


3358:tolhs-25thiaz-bala-betabthioph


3359:phhs-ithiadiaz-bala-betathio3


3360:ibhs-24thioph-bala-busu2be


3361:2py-53pyrazo-ala-betadcph


3362:tolhs-oxadiaz-gly-beta35dbph


3363:ibhs-ithiadiaz-bala-betahc


3364:phhs-oxadiaz-bala-betapytb


3365:phhs-oxadiaz-gly-betafbph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 117
3366: tolhs-me24oxaz-gly-betadcph
3367: bhs-25oxaz-bala-betapytb
3368: phhs-24thiaz-gly-betahdbph
3369: bim-26py-ala-betainyl
3370: phhs-24thioph-gly-betambiph
3371: bhs-nme35pyr-gly-betambiph
3372: bhs-ithiadiaz-bala-betamesu
3373: tolhs-nme35pyr-giy-psdapch
3374: bhs-25oxaz-nmgly-betabpy
3375: tolhs-me24thioph-ala-betapy
3376: phhs-24thiaz-gly-betameph
3377: phhs-25oxaz-giy-betaol
3378: bim-24thioph-bala-betahc
3379: bhs-nme35pyr-ala-betabpy
3380: ibhs-24thiaz-gly-betadhbfu
3381: bhs-25oxaz-gly-betahbcph
3382: tolhs-me24oxaz-leu-betaph
3383: 4pmhs-26py-gly-betapy
3384: ibhs-25thiaz-bala-betahbcph
3385: tolhs-24thiaz-bala-betadcph
3386: tolhs-oxadiaz-bala-betainyl
3387: tolhs-25methiaz-bala-psdap
3388: phhs-me24thioph-bala-betadcph
3389: phhs-oxadiaz-bala-betathio3
3390: phhs-24thioph-bala-asppha
3391: bhs-24thioph-bala-betainyl
3392: bhs-25oxaz-gly-betatluo
3393: ibhs-nme35pyr-bala-psdapee
3394: bim-me25oxaz-leu-betadcph
3395: tolhs-ithiadiaz-bala-betafu2
3396: phhs-25methiaz-gly-betabthioph
3397: bhs-24thiaz-bala-betafbph
3398: ibhs-nme35pyr-bala-betafluo
3399: bhs-ithiadiaz-nmgly-betal3bendi
3400: bhs-24thiaz-gly-betaol
3401: ibhs-oxadiaz-gly-suabu
3402: nmhs-42nmeim-gly-psdap


CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
- 118 -
3403:phhs-25methiaz-bala-asppha


3404:gua-26py-gly-beta34dcph


3405:phhs-ithiadiaz-bala-betadbph


3406:phhs-me25thioph-gly-psdap


3407:bhs-24thiaz-bala-betabediox


3408:bim-25thioph-ala-betadcph


3409:bhs-ithiadiaz-ala-ibsdap


3410:ibhs-25thiaz-bala-aspibua


3411:bhs-24thioph-bala-beta4bph


3412:ibhs-ithiadiaz-bala-betabnaphth


3413:2py-25methiaz-gly-betathio3


3414:bhs-ithiadiaz-gly-betampy


3415:phhs-nme35pyr-gly-betamethi


3416:ibhs-24thioph-bala-beta34meoph


3417:ibhs-25oxaz-bala-betafu3


3418:phhs-ithiadiaz-gly-betaimid


3419:tolhs-25oxaz-gly-betadcphch


3420:tolhs-24thioph-bala-betafbph


3421:ibhs-25thiaz-bala-betatbuph


3422:bhs-25oxaz-gly-psdaptb


3423:bim-me24thioph-bala-betaph


3424:bhs-24thiaz-gly-beta3quin


3425:bim-me24thiaz-leu-betadcph


3426:phhs-ithiadiaz-gly-beta13bendi


3427:tolhs-25methiaz-giy-aspibua


3428:tolhs-24thiaz-gly-betadhbfu


3429:bhs-42pym-ala-betadcph


3430:ibhs-nme35pyr-bala-betacthoph


3431:bhs-25oxaz-gly-betaanaphth


3432:ibhs-ithiadiaz-gly-betatos


3433:ibhs-nme35pyr-bala-betadcph


3434:ibhs-nme35pyr-bala-betatos


3435:tolhs-nme35pyr-bala-betahbcph


3436:2py-me25thioph-ala-betaph


3437:ibhs-oxadiaz-gly-busu2be


3438:bim-triaz-bala-zdap


3439:bhs-24thioph-gly-betampy




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 119 -
3440:bhs-35fur-bala-betapy


3441:bhs-me24thioph-leu-beta34meoph


3442:ibhs-25oxaz-bala-betaanaphth


3443:bhs-25oxaz-leu-zdap


3444:gua-24thiaz-gly-betadmoph


3445:bhs-ithiadiaz-bala-betacthioph


3446:bhs-25thiaz-gly-betapyr


3447:ibhs-ithiadiaz-gly-beta34dcph


3448:tolhs-oxadiaz-bala-betaheph


3449:tolhs-oxadiaz-gly-betapyee


3450:gua-24oxaz-gly-betambiph


3451:tolhs-24thioph-gly-betafu3


3452:tolhs-24thiaz-bala-zdaptb


3453:tolhs-ithiadiaz-gly-betaoxope


3454:phhs-nme35pyr-gly-betaftrif


3455:bhs-ithiadiaz-bala-betadcphtb


3456:bim-triaz-bala-psdap


3457:bhs-nme35pyr-gly-betapyr


3458:bhs-25oxaz-bala-betaipro


3459:tolhs-nme35pyr-gly-betabmph


3460:ibhs-24thiaz-bala-betadmph


3461:tolhs-24thiaz-gly-betaphethio


3462:agua-26py-gly-betadcph


3463:2py-triaz-gly-psdap


3464:2py-24thiaz-bala-betabnaphth


3465;tolhs-oxadiaz-bala-betaph


3466:ibhs-25methiaz-gly-aspaba


3467:bim-me24thiaz-gly-betaph


3468:bim-me24thioph-ala-betapy


3469:ibhs-24thiaz-bala-betaanaphth


3470:bim-42nmeim-ala-betapy


3471:ibhs-24thioph-bala-betahni


3472:bhs-24thioph-bala-asppha


3473:ibhs-24thiaz-bala-betahph


3474:bhs-25oxaz-bala-betahc


3475:tolhs-24thioph-gly-betah35dc


3476:bim-me24thioph-ala-beta34meoph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00/03469
- 120 -
3477:bim-me25oxaz-bala-beta34meoph


3478:tolhs-25thiaz-bala-aspaba


3479:ibhs-oxadiaz-bala-betampy


3480:bhs-35thioph-ala-betapy


3481:tolhs-24thioph-bala-betafph


3482:bhs-nme35pyr-bala-ibsdap


3483:2pmhs-24thioph-bala-betapyr


3484:phhs-24thiaz-gly-betafphe


3485:bhs-25oxaz-bala-betacbph


3486:tolhs-24thioph-gly-zdaptb


3487:bim-me24thiaz-leu-betapy


3488:bim-ithiadiaz-leu-betapy


3489:ibhs-ithiadiaz-bala-beta34dcph


3490:bhs-oxadiaz-bala-csdap


3491:phhs-25methiaz-bala-aspbzla


3492:2py-me24oxaz-gly-psdap


3493:bhs-24thioph-gly-csdap


3494:phhs-ithiadiaz-bala-betadcphch


3495:ibhs-nme35pyr-gly-asppha


3496:bhs-oxadiaz-gly-betaftrif


3497:bhs-25methiaz-bala-betabenfu


3498:gua-24thiaz-gly-betaomebendi


3499:bhs-me25thiaz-gly-beta34meoph


3500:bim-25methiaz-bala-betampy


3501:phhs-25oxaz-gly-betaphethio


3502:tolhs-24thiaz-gly-zdap


3503:bhs-nme35pyr-bala-betacph


3504:tolhs-nme35pyr-gly-betabdimo


3505:bhs-nme35pyr-bala-betadcphch


3506:bhs-25thiaz-bala-betabnaphth


3507:bhs-25thiaz-bala-betaph


3508:tolhs-oxadiaz-gly-betatrif


3509:2py-me24oxaz-leu-beta34meoph


3510:tolhs-ithiadiaz-bala-betathiome


3511:tolhs-25thiaz-bala-betapych


3512:tolhs-25oxaz-gly-betabediox


3513:tolhs-25methiaz-bala-betapym




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 121 -
3514:bhs-25thiaz-gly-betambiph


3515:phhs-ithiodiaz-bala-betaoxaz


3516:2py-42oxaz-bala-betadcph


3517:bhs-nme35pyr-gly-psdapee


3518:gua-24oxaz-gly-betafph


3519:phhs-24thioph-bala-betafphe


3520:bhs-25thiaz-bala-betapytb


3521:phhs-24thiaz-bala-betadcphch


3522:phhs-25thiaz-bala-betapyr


103523:tolhs-nme35pyr-gly-psdaptb


3524:tolhs-nme35pyr-bala-suabu


3525:bhs-42oxaz-bala-betadcph


3526:phhs-25methiaz-gly-betapych


3527:impy-25methiaz-bala-betainyl


153528:phhs-25thiaz-gly-ibsdap


3529:phhs-25oxaz-gly-betabnaphth


3530:bhs-oxadiaz-gly-betatos


3531:tolhs-25thiaz-gly-betambiph


3532:bhs-25methiaz-bala-psdaptb


203533:impy-24thiaz-gly-betathiobe


3534:bhs-25methiaz-bala-betamethioph


3535:bhs-25thiaz-nmgly-betainyl


3536:bhs-ithiadiaz-bala-betadito


3537:gua-24thiaz-gly-betabenfu


253538:ibhs-24thiaz-bala-betadtrif


3539:phhs-me25thioph-leu-betapy


3540:phhs-me25thiaz-gly-betaph


3541:ibhs-ithiadiaz-gly-betabnaphth


3542:ibhs-25oxaz-gly-betahbcph


303543:bhs-25thiaz-nmgly-beta3quin


3544:impy-24thioph-gly-betahmofu


3545:bhs-24thioph-gly-betapym


3546:2py-52thiaz-gly-zdap


3547:phhs-oxadiaz-bala-betaibph


353548:2pmhs-25methiaz-bala-beta4bph


3549:tolhs-25methiaz-gly-betaet


3550:bhs-25thiaz-ala-betahmph




CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
- 122 -
3551: bhs-25thioph-leu-betapy


3552: bhs-25methiaz-gly-suabu


3553: phhs-oxadiaz-bala-suabu


3554: phhs-25thiaz-bala-psdap


3555: phhs-me24thioph-leu-psdap


3556: bim-24thioph-gly-betaibph


3557: ibhs-oxadiaz-gly-betapy


3558: tolhs-24thiaz-bala-betaanaphth


3559: phhs-oxadiaz-bala-betaoxope


103560: bhs-24thiaz-bala-betapyee


3561: ibhs-24thiaz-gly-betahb


3562: tolhs-oxadiaz-bala-betahdbph


3563: bhs-24thiaz-gly-betabph


3564: bhs-ithiadiaz-ala-beta34dcph


153565: ibhs-24thiaz-bala-betatbuph


3566: ibhs-24thiaz-gly-betaipro


3567: bhs-ithiadiaz-ala-betadcph


3568: bhs-25thiaz-bala-betafbph


3569: phhs-25oxaz-gly-zdapch


203570: ibhs-24thiaz-gly-betabediox


3571: ibhs-25methiaz-gly-betadmoph


3572: phhs-24thioph-gly-betaipr


3573: bhs-ithiadiaz-bala-betabph


3574: tolhs-nme35pyr-gly-psdapee


253575: bim-42oxaz-bala-psdap


3576: ibhs-25oxaz-bala-betafluo


3577: tolhs-nme35pyr-gly-betahmo


3578: bhs-25methiaz-bala-aspaba


3579: bhs-25thioph-gly-zdap


303580: phhs-25oxaz-gly-betadmph


3581: bhs-oxadiaz-bala-betapyr


3582: gua-26py-gly-betamethioph


3583: 2py-25thioph-bala-betapy


3584: bhs-oxadiaz-ala-betathioph


353585: bim-thiadiaz-bala-zdap


3586: bim-25oxaz-bala-betamethioph


3587: bhs-25methiaz-nmgly-betamesu




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-123-
3588:dhpyrr-26py-gly-betadcph


3589:2py-me25thiaz-gly-beta34rneoph


3590:phhs-oxadiaz-giy-betahcbph


3591:2py-me25thioph-gly-beta34meoph


3592:phhs-25methiaz-gly-betaibph


3593:ibhs-nme35pyr-bala-betamesu


3594:ibhs-24thioph-bala-betabpy


3595:ibhs-24thioph-bala-betadcphee


3596:ibhs-oxadiaz-gly-betacthioph


3597:gua-24oxaz-gly-betathiome


3598:gua-42pym-gly-betaoxope


3599:2py-25oxaz-gly-aspbzla


3600:bhs-oxadiaz-gly-betadhbfu


3601:phhs-25methiaz-bala-betacthioph


3602:bim-25methiaz-bala-betaipro


3603:jbhs-ithiadiaz-gly-betadito


3604:tolhs-nme35pyr-bala-betahdbph


3605:bim-me24thioph-gly-beta34meoph


3606:phhs-me24thioph-gly-betapy


3607:bhs-35fur-leu-psdap


3608:ibhs-24thiaz-gly-betadmph


3609:dhim-24thiaz-gly-betainyl


3610:bhs-42oxaz-gly-betadcph


3611:ibhs-24thiaz-bala-betaet


3612:phhs-nme35pyr-gly-betahb


3613:gua-24thiaz-gly-betabpy


3614:2py-52thiaz-gly-psdap


3615:tolhs-25methiaz-bala-suabu


3616:phhs-25oxaz-gly-betabdimo


3617:bhs-nme35pyr-nmgly-betadmph


3618:ibhs-oxadiaz-gly-betadmoph


3619:phhs-nme35pyr-gly-aspaba


3620:phhs-nme35pyr-bala-betamesu


3621:bhs-25thiaz-bala-betathiobe


3622:bhs-24thiaz-leu-psdap


3623:bhs-25thiaz-gly-betadtrif


3624:ibhs-25methiaz-gly-betapyee




CA 02371604 2001-10-24
WO 00166618 PCT/EP00103469
-124
3625: bim-35thioph-gly-psdap


3626: bhs-25oxaz-gly-betadtrif


3627: bhs-oxadiaz-bala-betadcph


3628: bim-25thiaz-ala-betapy


3629: 2py-24thiaz-gly-asppha


3630: bhs-oxadiaz-gly-betaamibe


3631: bhs-ithiadiaz-nmgly-beta34dcpth


3632: bim-24thiaz-gly-betameph


3633: phhs-me24oxaz-gly-psdap


3634:bim-me24thiaz-gly-psdap


3635: bhs-oxadiaz-gly-betaheph


3636: thpy-24thioph-gly-betadcph


3637: gua-25thioph-gly-betaoxope


3638: bhs-42pym-gly-betameph


3639:bhs-24thiaz-gly-betafu2


3640: tolhs-25oxaz-gly-betaheph


3641: bhs-25oxaz-nmgly-betahmph


3642: impy-25oxaz-gly-betapym


3643: gua-25thiaz-gly-betamethi


3644:phhs-oxadiaz-bala-betacthioph


3645: bhs-24thioph-gly-betaibph


3646: phhs-25methiaz-bala-betahmofu


3647: bhs-25oxaz-gly-betacthioph


3648: bhs-oxadiaz-bala-betaipr


3649:phhs-24thioph-gly-betaamibe


3650: phhs-nme35pyr-gly-betaamibe


3651: phhs-25methiaz-gly-betaphethio


3652: phhs-25thiaz-gly-betapbiph


3653: ibhs-25oxaz-gly-betapy


3654:tolhs-nme35pyr-gly-aspibua


3655: ibhs-24thiaz-gly-psdapch


3656: 2py-35fur-ala-psdap


3657: tolhs-24thiaz-bala-betaomebendi


3658: ibhs-25methiaz-bala-betadhbfu


3659:ibhs-25methiaz-bala-betaoxaz


3660: bim-25methiaz-gly-asppha


3661: phhs-ithiadiaz-bala-betadmoph




CA 02371604 2001-10-24
WO 0016661$ PCTIEP00103469
-125-
3662:bhs-35fur-ala-betadcph


3663:phhs-25thiaz-bala-betatos


3664:bim-42nmeim-gly-betafu3


3665:bhs-24thioph-gly-beta35dbph


3666:ibhs-nme35pyr-bala-betadhbfu


3667:cima-24thiaz-bala-psdap


3668:tolhs-25methiaz-bala-betaol


3669:gua-26py-gly-betaipr


3670:tolhs-ithiadiaz-bala-betaipr


103671:ibhs-nme35pyr-gly-csdap


3672:tolhs-24thiaz-gly-betafph


3673:phhs-25methiaz-bala-betaphethio


3674:phhs-ithiadiaz-bala-betafphe


3675:tolhs-24thioph-bala-beta23meoph


153676:phhs-25thiaz-bala-aspbzla


3677:tolhs-oxadiaz-gly-betacbph


3678:bhs-24thiaz-ala-betabnaphth


3679:phhs-25methiaz-bala-betapbiph


3680:2py-24im-ala-psdap


203681:tolhs-24thiaz-bala-betathiobe


3682:pbhs-oxadiaz-giy-betaphethio


3683:tolhs-25oxaz-gly-betahbcph


3684:tolhs-oxadiaz-bala-betacbph


3685:tolhs-25oxaz-gly-beta34meoph


253686:bhs-25oxaz-gly-betathiome


3687:dhim-42nmeim-gly-zdap


3688:ibhs-ithiadiaz-gly-betabthioph


3689:ibhs-oxadiaz-gly-betaet


3690:bhs-25methiaz-nmgly-beta34dcph


303691:ibhs-25oxaz-gly-beta23meoph


3692:phhs-25methiaz-gly-betacph


3693:ibhs-nme35pyr-gly-betathio3


3694:bim-me24thiaz-gly-betadcph


3695:phhs-24thioph-gly-csdap


353696:ibhs-nme35pyr-bala-asppha


3697:2py-me24thioph-ala-psdap


3698:tolhs-25oxaz-gly-zdapee




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 126
3699: dhim-26py-gly-psdap


3700: 2py-25thioph-bala-zdap


3701: tolhs-25oxaz-bala-psdapch


3702: phhs-24thioph-gly-zdapch


3703: bim-thiadiaz-bala-betadcph


3704: bim-24oxaz-bala-betadcph


3705: tolhs-25oxaz-gly-psdap


3706: bim-52thiaz-gly-zdap


3707: ibhs-oxadiaz-baia-betadito


103708: bhs-me24thiaz-bala-zdap


3709: 2py-ithiadiaz-bala-asppha


3710: gua-42pym-gly-betafu2


3711: phhs-25methiaz-bala-betaanaphth


3712: bhs-26py-ala-zdap


153713: ibhs-24thiaz-gly-betaoxope


3714: phhs-24thioph-bala-betadcphee


3715: dhim-52thiaz-ala-betainyl


3716: phhs-ithiadiaz-bala-betaanaphth


3717: bhs-24thioph-gly-betafph


203718: gua-24thiaz-gly-betahb


3719: bhs-oxadiaz-gly-betaipro


3720: phhs-25methiaz-gly-betatrif


3721: bim-me24thioph-gly-zdap


3722: ibhs-oxadiaz-bala-betaoxaz


253723: gua-24thiaz-gly-betacbph


3724: ibhs-ithiadiaz-gly-betahni


3725: bim-ithiadiaz-bala-aspibua


3726: 2py-42oxaz-gly-betadcph


3727: tolhs-ithiadiaz-gly-betaet


303728: ibhs-25methiaz-bala-betahdcph


3729: 2py-42nmeim-gly-betacph


3730: tolhs-oxadiaz-bala-betaanaphth


3731: phhs-ithiadiaz-gly-betaanaphth


3732: phhs-ithiadiaz-gly-betafluo


353733: tolhs-ithiadiaz-bala-betaftrif


3734: phhs-oxadiaz-gly-betaet


3735: phhs-24thiaz-bala-csdap




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 127
3736: ibhs-25oxaz-bala-psdap


3737: 2pmhs-25oxaz-gly-betaol


3738: tolhs-oxadiaz-gly-betadcph


3739: phhs-24thioph-bala-betamesu


3740: bhs-25thiaz-gly-betadito


3741: 2py-42pym-ala-betainyl


3742: tolhs-me25oxaz-gly-zdap


3743: 2pmhs-25oxaz-gly-beta3quin


3744: phhs-24thiaz-bala-betahmo


103745: tolhs-24thiaz-bala-csdap


3746: bhs-26py-gly-betapy


3747: bim-53pyrazo-leu-betapy


3748: 2py-25methiaz-gly-zdap


3749: ibhs-nme35pyr-gly-betadtrif


153750: dhim-42pym-ala-betadcph


3751: ibhs-nme35pyr-bala-zdaptb


3752: bim-25thiaz-gly-betadbph


3753: tolhs-25oxaz-bala-betahrnph


3754: tolhs-25methiaz-bala-betahph


203755: ibhs-ithiadiaz-gly-betapyr


3756: bhs-ithiadiaz-ala-betaipro


3757: ibhs-25methiaz-bala-psdapch


3758: phhs-nme35pyr-bala-zdapee


3759: bim-me25thiaz-bala-beta34meoph


253760: tolhs-oxadiaz-bala-betahdcph


3761: phhs-oxadiaz-gly-betampy


3762: ibhs-oxadiaz-gly-betathiome


3763: impy-2thioph-gly-betapy


3764: bhs-25oxaz-gly-betainyl


303765: ibhs-25thiaz-bala-betafph


3766: tolhs-ithiadiaz-gly-betafphe


3767: hts-42pym-gfy-betapy


3768: ibhs-24thiaz-gly-betahmph


3769: phhs-nme35pyr-bala-betapyee


353770: tolhs-nme35pyr-gly-beta34meoph


3771: bim-me25thioph-bala-betaph


3772: tolhs-24thiaz-bala-betadmph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 128
3773:bhs-ithiadiaz-gly-betaamibe


3774:bhs-25thioph-leu-psdap


3775:bhs-me25thiaz-leu-betaph


3776:bhs-25methiaz-bala-csdap


3777:tolhs-25thiaz-gly-beta4bph


3778:bhs-24thioph-nmgly-betainyl


3779:phhs-oxadiaz-gly-betabenfu


3780:phhs-nme35pyr-gly-psdaptb


3781:gua-24thiaz-gly-betatos


3782:tolhs-oxadiaz-gly-betabdimo


3783:bhs-25thiaz-gly-betafluo


3784:bhs-triaz-ala-psdap


3785:bhs-35pyrazo-gly-betapy


3786:2pmhs-24thiaz-bala-betapyr


3787:tolhs-25methiaz-bala-betaphethioa


3788:bhs-24thiaz-bala-betahdbph


3789:ibhs-25thiaz-gly-betadcphee


3790:phhs-24thioph-bala-betadito


3791:phhs-oxadiaz-gly-betabdimo


3792:2py-24thiazme-gly-betapy


3793:ibhs-nme35pyr-gly-beta34meoph


3794:phhs-ithiadiaz-gly-betahbcph


3795:ibhs-oxadiaz-gly-betaibph


3796:2py-24thioph-bala-psdap


3797:2pmhs-25oxaz-bala-suabu


3798:bhs-24thioph-nmgly-betabpy


3799:ibhs-oxadiaz-bala-asppha


3800:gua-25thiaz-gly-betaomebendi


3801:3pmhs-42pym-gfy-betapy


3802:tolhs-25thiaz-gly-suabu


3803:ibhs-24thioph-bala-betafu2


3804:tolhs-oxadiaz-bala-psdapch


3805:ibhs-oxadiaz-bala-betadcphtb


3806:phhs-ithiadiaz-bala-betaftrif


3807:ibhs-oxadiaz-gly-betaoxope


3808:2py-oxadiaz-bala-psdap


3809:tolhs-me25oxaz-gly-psdap




CA 02371604 2001-10-24
WO 00!66618 PCTlEP00103469
-129-
3810:bhs-25methiaz-nmgly-beta13bendi


3811:tolhs-24thiaz-bala-betabpy


3812:hs-42pym-gly-betapy


3813:tolhs-25oxaz-bala-betapbiph


3814:ibhs-oxadiaz-bala-beta34meoph


3815:bhs-ithiadiaz-ala-betameph


3816:phhs-me24oxaz-leu-beta34meoph


3817:bhs-25thiaz-nmgly-betafphe


3818:tolhs-ithiadiaz-gly-betafluo


103819:tolhs-25thiaz-bala-betamethi


3820:bhs-24thioph-nmgly-betathio3


3821:bhs-24thiaz-hphe-betapy


3822:tolhs-25methiaz-bala-aspbzla


3823:bim-me25thiaz-ala-betadcph


153824:bhs-25thiaz-bala-asppha


3825:bhs-nme35pyr-gly-betamesu


3826:ibhs-ithiadiaz-gly-betapyee


3827:phhs-25oxaz-bala-betabnaphth


3828:ibhs-24thioph-gly-betadmoph


203829:phhs-ithiadiaz-gly-betabnaphth


3830:tolhs-nme35pyr-gly-beta3quin


3831:bhs-me25thioph-bala-betapy


3832:tolhs-nme35pyr-bala-betapym


3833:bhs-nme35pyr-ala-beta3quin


253834:ibhs-25oxaz-gly-betamethioph


3835:tolhs-25thiaz-gly-betaoxaz


3836:phhs-ithiadiaz-bala-betadcphee


3837:tolhs-24thiaz-bala-betaphethioa


3838:2py-25oxaz-gly-betadcph


303839:tolhs-oxadiaz-bala-betampy


3840:2py-42oxaz-leu-betapy


3841:ibhs-24thiaz-gly-zdaptb


3842:phhs-ithiadiaz-bala-psdaptb


3843:phhs-nme35pyr-gly-betafluo


353844:bhs-nme35pyr-gly-zdapee


3845:ibhs-24thioph-bala-betaoxaz


3846:ibhs-24thiaz-bala-betaoxaz




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 130
3847: thazep-25thiaz-gly-beta13bendi


3848: bhs-24thioph-ala-betabnaphth


3849: bhs-ithiadiaz-nmgly-betamesu


3850: phhs-oxadiaz-giy-betacph


3851: ibhs-25methiaz-bala-betapyr


3852: 2py-25methiaz-gly-betaol


3853: tolhs-25methiaz-gly-betahbcph


3854: ibhs-25thiaz-bala-betadmph


3855: phhs-25thiaz-gly-beta35dbph


3856:ibhs-25thiaz-gly-csdap


3857: phhs-25thiaz-gly-betamethioph


3858: 2py-24thiaz-gly-betathio3


3859; ibhs-ithiadiaz-bala-betahni


3860: gua-25thioph-gly-betathio3


3861:bhs-oxadiaz-gly-beta34dcph


3862: dhim-25thiophme-ala-betameph


3863: ibhs-nme35pyr-bala-betahdcph


3864: tolhs-nme35pyr-bala-betathio3


3865: bhs-24thioph-gly-betacthioph


3866:phhs-25thiaz-bala-betaol


3867: ibhs-24thiaz-gly-ibsdap


3868: bhs-me24im-gly-betameph


3869: tolhs-24thiaz-giy-betabnaphth


3870: tolhs-me25thiaz-bala-zdap


3871:2py-35fur-bala-zdap


3872; tolhs-oxadiaz-bala-betabthioph


3873: bhs-ithiadiaz-gly-betahph


3874: bgua-25methiaz-gly-betameph


3875: phhs-ithiadiaz-bala-betabediox


3876:phhs-25methiaz-bala-betadcph


3877: ibhs-nme35pyr-gly-betapbiph


3878: tolhs-25methiaz-gly-betabenfu


3879: bim-25thiaz-bala-psdap


3880: bhs-25methiaz-gly-betaet


3881:phhs-me25thioph-bala-psdap


3882: tolhs-25thiaz-gly-betaoxope


3883: toihs-ithiadiaz-gly-betafu2




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 131 -
3884:ibhs-oxadiaz-bala-betabpy


3885:bim-25methiaz-gly-aspaba


3886:ibhs-nme35pyr-bala-betaamibe


3887:bhs-25methiaz-bala-betainyl


3888:bhs-ithiadiaz-gly-psdapee


3889:bgua-25oxaz-bala-betapy


3890:phhs-25methiaz-gly-betamesu


3891:phhs-25methiaz-bala-betaftrif


3892:ibhs-25thiaz-bala-betaanaphth


3893:ibhs-oxadiaz-bala-beta3quin


3894:phhs-25methiaz-bala-zdapch


3895:phhs-nme35pyr-bala-ibsdap


3896:2pmhs-25methiaz-bala-betathioph


3897:bhs-me24thiaz-leu-betapy


3898:phhs-25thiaz-bala-betathiome


3899:tolhs-25thiaz-gly-betapbiph


3900:gua-25thioph-gly-betahmo


3901:bim-25thioph-bala-betapy


3902:tolhs-oxadiaz-bala-beta35dbph


3903:tolhs-ithiadiaz-gly-aspbzla


3904:tolhs-nme35pyr-bala-betacthioph


3905:bhs-triaz-gly-psdap


3906:ibhs-oxadiaz-bala-betadhbfu


3907:phhs-me25oxaz-leu-zdap


3908:tolhs-oxadiaz-gly-betamethioph


3909:bhs-25oxaz-bala-betadbph


3910:bhs-oxadiaz-bala-betameph


3911:phhs-24thiaz-gly-aspaba


3912:bim-25thiaz-bala-betaimid


3913:2py-24thioph-leu-betadcph


3914:ibhs-25oxaz-gly-betaanaphth


3915:ibhs-nme35pyr-gly-betapyr


3916:tolhs-24thioph-gly-beta35dbph


3917:2pmhs-25methiaz-bala-betapyr


3918:tolhs-25thiaz-gly-betadmph


3919:2py-25methiaz-leu-betapy


3920:bhs-oxadiaz-bala-asppha




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 132 -
3921:bhs-25oxaz-gly-betahb


3922:tolhs-24thioph-bala-betameph


3923:phhs-me25oxaz-leu-beta34meoph


3924:2py-42nmeim-bala-betapy


3925:phhs-me25thiaz-ala-betapy


3926:phhs-25methiaz-bala-betampy


3927:ibhs-25oxaz-bala-suabu


3928:bhs-oxadiaz-gly-betabmph


3929:bhs-25oxaz-bala-betambiph


3930:tolhs-nme35pyr-gly-aspbzla


3931:ibhs-nme35pyr-gly-betapych


3932:ibhs-24thiaz-gly-betaph


3933:bhs-24thiaz-bala-betacthioph


3934:bhs-me25oxaz-leu-beta34meoph


3935:bhs-25oxaz-bala-betahbcph


3936:tolhs-25oxaz-bala-betafbph


3937:tolhs-25methiaz-bala-betabmph


3938:bhs-nme35pyr-nmgly-betadhbfu


3939:phhs-25methiaz-bala-betahni


3940:bhs-24thioph-bala-beta34meoph


3941:2py-24thioph-gly-betadito


3942:bhs-25oxaz-gly-betahph


3943:bhs-25methiaz-gly-psdaptb


3944:ibhs-nme35pyr-gly-betapym


3945:ibhs-ithiadiaz-gly-betadmph


3946:bim-24im-leu-zdap


3947:impy-25thiaz-gly-beta34meoph


3948:ur-42pym-ala-psdap


3949:bhs-ithiadiaz-bala-betafbph


3950:bhs-24thiaz-gly-betatos


3951:ibhs-24thioph-gly-zdapee


3952:tolhs-25methiaz-bala-betadcphtb


3953:ibhs-ithiadiaz-bala-betahmo


3954:ibhs-nme35pyr-bala-betahb


3955:phhs-25oxaz-gly-betaet


3956:ibhs-24thiaz-gly-betathio3


3957:bhs-25methiaz-gly-betahmph




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
- 133 -
3958:bhs-42oxaz-ala-psdap


3959:gua-25thiaz-gly-betapy


3960:ibhs-nme35pyr-bala-betahbcph


3961:phhs-nme35pyr-bala-betathiome


3962:bim-25methiaz-bala-psdap


3963:bhs-24thiaz-ala-betadmph


3964:phhs-25methiaz-gly-betathiome


3965:phhs-me25thioph-bala-betadcph


3966:bhs-ithiadiaz-bala-betathiome


3967:bhs-nme35pyr-bala-betathioph


3968:bim-24thioph-bala-betaimid


3969:phhs-24thioph-gly-betaftrif


3970:bhs-25thiaz-gly-betadcph


3971:phhs-me25thioph-gly-betaph


3972:bim-25methiaz-ala-betapy


3973:bhs-24thioph-ala-betathio3


3974:ibhs-24thiaz-bala-aspbzla


3975:phhs-oxadiaz-bala-betahmph


3976:bhs-ithiadiaz-ala-betaanaphth


3977:bhs-25oxaz-gly-aspaba


3978:bhs-ithiadiaz-gly-betaol


3979:2py-thiadiaz-leu-betadcph


3980:phhs-me25oxaz-bala-betapy


3981:ibhs-25oxaz-gly-beta34dcph


3982:ibhs-oxadiaz-gly-betabmph


3983:bhs-oxadiaz-bala-beta4bph


3984:tolhs-24thiaz-bala-betafu3


3985:bhs-25oxaz-bala-betafu2


3986:tolhs-me25thiaz-ala-psdap


3987:tolhs-25oxaz-bala-betamesu


3988:2py-26py-gly-betahdcph


3989:bhs-25methiaz-met-betadcph


3990:bhs-me25oxaz-bala-beta34meoph


3991:bim-me24thioph-gly-betaph


3992:bhs-25oxaz-gly-betaibph


3993:phhs-oxadiaz-gly-betahdbph


3994:tolhs-me25oxaz-ala-betadcph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 134 -
3995: 2py-25fur-gly-zdap


3996: bim-thiadiaz-leu-betapy


3997: tolhs-24thiaz-bala-betathioph


3998: 2py-24thioph-gly-betathio3


3999: bhs-24thiaz-gly-betahmo


4000: phhs-nme35pyr-gly-betabenfu


4001: ibhs-25thiaz-bala-betapych


4002: bhs-24oxaz-ala-zdap


4003: impy-24thiaz-bala-betamethi


104004: ibhs-oxadiaz-gly-betaphethio


4005: tolhs-25thiaz-bala-betaet


4006: phhs-25methiaz-bala-betahmph


4007: phhs-oxadiaz-bala-betadito


4008: bim-25fur-ala-betadcph


154009: tolhs-oxadiaz-bala-beta34meoph


4010: bhs-24thioph-ala-betamesu


4011: phhs-25thiaz-gly-betadmoph


4012: bhs-nme35pyr-ala-betaipro


4013: tolhs-25thiaz-gly-betabpy


204014: ibhs-nme35pyr-gly-betaipr


4015: bhs-25methiaz-gly-betabmph


4016: tolhs-25oxaz-bala-betapych


4017: tolhs-oxadiaz-gly-csdap


4018: tolhs-nme35pyr-bala-beta35dbph


254019: 2py-me25thioph-leu-beta34meoph


4020: phhs-oxadiaz-bala-betahni


4021: ibhs-24thioph-bala-betadmph


4022: bhs-25methiaz-gly-betadito


4023: bhs-42nmeim-ala-betadcph


304024: ibhs-25oxaz-bala-betaphethioa


4025: bim-me24thiaz-bala-zdap


4026: bhs-42py-gly-betameph


4027: tolhs-24thioph-gly-betahmph


4028: bim-me24thioph-ala-zdap


354029: bim-me25thiaz-gly-beta34meoph


4030: bhs-25thiaz-bala-betabthioph


4031: bim-25thiaz-gly-aspaba




CA 02371604 2001-10-24
WO 00166618 PCTIEP0010346g
- 135
4032: gua-24thiaz-gly-betafbph


4033: thpym-42pym-gly-betahcbph


4034: bhs-nme35pyr-bala-betaamibe


4035: bhs-25oxaz-gly-betapbiph


4036: phhs-25thiaz-gly-betahc


4037: 2py-nme35pyr-bala-aspibua


4038: bim-24oxaz-gly-betadcph


4039: phhs-24thioph-gly-betahbcph


4040: 2py-me25thioph-leu-betapy


104041: bhs-me25thioph-ala-psdap


4042: bhs-me25oxaz-leu-betapy


4043: tolhs-ithiadiaz-bala-betahmofu


4044: 2py-25th iaz-bala-betabn
aphth


4045: bim-24thiaz-gly-betadmph


154046: ibhs-24thiaz-gly-betaol


4047: tolhs-25thiaz-gly-betafbph


4048: bhs-42nmeim-bala-betapy


4049: phhs-25methiaz-gly-betahb


4050: phhs-25thiaz-bala-betacbph


204051: tolhs-nme35pyr-gly-zdapee


4052: phhs-ithiadiaz-bala-zdaptb


4053: thazep-25thiaz-bala-zdap


4054: 2py-24chin-gly-betapy


4055: ibhs-25methiaz-gly-betapytb


254056: bhs-25thiaz-bala-betadcphtb


4057: phhs-25methiaz-bala-beta13bendi


4058: tolhs-24thiaz-gly-betapbiph


4059: bhs-ithiadiaz-gly-betaipr


4060: 2py-35thioph-gly-zdap


304061: phhs-me25thiaz-gly-zdap


4062: ibhs-24thioph-bala-betadcph


4063: tolhs-25oxaz-gly-betambiph


4064: bhs-nme35pyr-gly-betahmph


4065: bhs-25methiaz-ala-psdap


354066: tolhs-25thiaz-bala-betafph


4067: tolhs-ithiadiaz-gly-betabph


4068: tolhs-nme35pyr-bala-aspaba




CA 02371604 2001-10-24
WO 00166618 PCTIEP00l03469
-136-
4069:2py-42oxaz-ala-zdap


4070:ibhs-nme35pyr-bala-betadcphch


4071:2py-24thiaz-ala-betameph


4072:2py-24thiaz-gly-betaol


4073:ibhs-25methiaz-bala-betapych


4074:2pmhs-24thiaz-gly-betadtrif


4075:dhim-26pyrazi-gly-betameph


4076:tolhs-24thiaz-gly-betadcph


4077:ibhs-nme35pyr-bala-betapym


4078:ibhs-25methiaz-bala-betahb


4079:bhs-24thioph-bala-betadcph


4080:ibhs-oxadiaz-gly-betapyee


4081:bhs-25thiaz-gly-aspibua


4082:bim-me25thiaz-leu-betadcph


4083:phhs-25methiaz-bala-betatos


4084:phhs-me25thiaz-ala-psdap


4085:bhs-25methiaz-ala-ibsdap


4086:bim-52thiaz-ala-betadcph


4087:phhs-24thiaz-bala-betambiph


4088:phhs-ithiadiaz-gly-beta3quin


4089:bhs-24thioph-gly-betapbiph


4090:2py-25oxaz-bala-betaftrif


4091:bhs-oxadiaz-ala-betameph


4092:tolhs-oxadiaz-bala-betaoxaz


4093:ibhs-oxadiaz-bala-betaibph


4094:bhs-24thiaz-gly-betaph


4095:ibhs-nme35pyr-gly-betafbph


4096:tolhs-nme35pyr-gly-betaanaphth


4097:phhs-24thiaz-gly-betamesu


4098:bhs-25oxaz-ala-betadcph


4099:tolhs-ithiadiaz-bala-betaimid


4100:impy-25oxaz-gly-betabph


4101:dhim-42pym-gly-betadtrif


4102:2py-me25thioph-bala-betapy


4103:ibhs-24thioph-gly-betadtrif


4104:2py-me24thioph-bala-beta34meoph


4105:bhs-25thiaz-nmgly-ibsdap




CA 02371604 2001-10-24
WO 00166618 PCTlEP00103469
-137-
4106: phhs-nme35pyr-bafa-betahmo


4107: phhs-25oxaz-gly-betaheph


4108: gua-42pym-gly-betainyl


4109: gua-42pym-gly-betaomebendi


4110: bhs-25thiaz-bala-betahbcph


4111: tolhs-25oxaz-bala-betabthioph


4112: bhs-nme35pyr-nmgly-betahrnph


4113: ibhs-25oxaz-gly-betadmoph


4114: tolhs-nme35pyr-bala-betabmph


104115: tolhs-nme35pyr-bala-betapbiph


4116: bhs-25oxaz-bafa-betahdcph


4117: impy-24thioph-bala-betamethi


4118: bim-me24oxaz-gly-beta34meoph


4119: phhs-me25oxaz-ala-betapy


154120: bim-me24thioph-gly-psdap


4121: bhs-24thioph-gly-betahph


4122: phhs-24thioph-gly-betaol


4123: ibhs-25thiaz-bala-zdaptb


4124: tolhs-nme35pyr-gly-betaamibe


204125: bhs-24thiaz-bala-betahb


4126: bhs-24thiaz-gly-zdapch


4127: gua-42pym-gly-betapyr


4128: phhs-oxadiaz-gly-zdapee


4129: bim-25thiaz-ala-psdap


254130: bhs-ithiadiaz-gly-betapy


4131: bhs-25methiaz-gly-betacph


4132: ibhs-25oxaz-gly-betaet


4133: 2py-42py-gly-betapy


4134: 2py-25oxaz-gly-betapy


304135: bhs-oxadiaz-gly-betafph


4136: ibhs-24thioph-gly-beta3quin


4137: tolhs-25oxaz-bala-betadcphee


4138: 2py-me25oxaz-ala-psdap


4139: bhs-24thioph-nmgly-betadito


354140: bhs-nme35pyr-gly-betahdcph


4141: bhs-oxadiaz-bala-betamethi


4142: bhs-nme35pyr-gly-betadcphee




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-138
4143:bhs-25methiaz-bala-betaibph


4144:bhs-24thioph-bala-beta23meoph


4145:ibhs-oxadiaz-bala-betatos


4146:tolhs-ithiadiaz-bala-betadtrif


4147:bhs-oxadiaz-gly-betapych


4148:tolhs-ithiadiaz-bala-betaamibe


4149:bhs-24thiaz-bala-betadbph


4150:bhs-24thioph-bala-betaphethioa


4151:phhs-25oxaz-bala-betadcphch


1D4152:tolhs-24thiaz-gly-betafluo


4153:phhs-25methiaz-gly-betaimid


4154:tolhs-oxadiaz-gly-betadtrif


4155:bhs-nme35pyr-ala-betadmph


4156:bim-25thiaz-bala-betampy


154157:phhs-25methiaz-bala-betathioph


4158:phhs-nme35pyr-gly-zdapch


4159:bhs-25methiaz-gly-betatos


4160:tolhs-25oxaz-bala-betahc


4161:2py-me24thiaz-ala-beta34meoph


204162:tolhs-me24thioph-gly-beta34meoph


4163:bim-oxadiaz-gly-betadcph


4164:ibhs-25thiaz-bala-betapbiph


4165:bhs-25thiaz-bala-betatos


4166:2py-25methiaz-bala-betapy


254167:tolhs-25methiaz-bala-zdapch


4168:gua-42pym-gly-betafluo


4169:bhs-nme35pyr-bala-betaphethioa


4170:tolhs-24thioph-bala-psdapee


4171:phhs-25oxaz-gly-ibsdap


304172:ibhs-25thiaz-gly-betabnaphth


4173:2py-25thiaz-gly-beta35dbph


4174:ibhs-oxadiaz-gly-betaimid


4175:bhs-me25thioph-ala-betapy


4176:phhs-24thioph-gly-betathioph


354177:ibhs-24thiaz-gly-betaomebendi


4178:bim-25fhiaz-ala-zdap


4179:ibhs-25methiaz-bala-betahmph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-139-
4180: ibhs-24thioph-gly-betahbcph


4181: bim-25oxaz-gly-betahbcph


4182: bhs-ithiadiaz-g1y-betadito


4183: bhs-24thioph-nmgly-betaipro


4184: bim-35thioph-ala-zdap


4185: ibhs-25oxaz-gly-betadcphch


4186: phhs-24thiaz-bala-zdapee


4187: bhs-me24thiaz-bala-betaph


4188: bim-nme35pyr-ala-zdap


4189:tolhs-25thiaz-gly-betaomebendi


4190: bhs-24thioph-gly-psdapee


4191: tolhs-nme35pyr-bala-zdap


4192: tolhs-nme35pyr-gly-aspaba


4193: ibhs-oxadiaz-bala-betatbuph


4194:tolhs-25oxaz-gly-betameph


4195: 2py-thiadiaz-bala-betadcph


4196: bim-24im-gly-betapy


4197: phhs-24thioph-gly-betadtrif


4198: bhs-nme35pyr-bala-betabph


4199:2py-24thioph-bala-aspibua


4200: bhs-25methiaz-bala-betafbph


4201: bhs-24thiaz-bala-betaibph


4202: impy-25thiaz-nmgly-psdap


4203: phhs-oxadiaz-gly-betatos


4204:phhs-24thioph-gly-betal3bendi


4205: bim-triaz-leu-betadcph


4206: phhs-25methiaz-bala-csdap


4207: phhs-nme35pyr-gly-betainyl


4208: ibhs-nme35pyr-bala-beta4bph


4209:phhs-ithiadiaz-bala-betahni


4210: 2py-24th iaz-ala-psdap


4211: tolhs-25thiaz-bala-beta4bph


4212: bhs-25thiaz-gly-beta34dcph


4213: bhs-25thiaz-bala-betafu3


4214:phhs-24thioph-gly-beta35dbph


4215: phhs-24thiaz-gly-betadmoph


4216: bhs-oxadiaz-ala-beta13bendi




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-140-
4217: 2pmhs-25oxaz-bala-betafluo


4218: phhs-25oxaz-gly-zdaptb


4219: phhs-24thiaz-bala-betamesu


4220: ibhs-24thioph-gly-betaph


4221: tolhs-nme35pyr-gly-betafphe


4222: bhs-25methiaz-gly-betabthioph


4223: bhs-25thiaz-bala-psdap


4224: tolhs-25methiaz-gly-betaibph


4225: bhs-me25oxaz-leu-betadcph


4226:2pmhs-25oxaz-bata-beta34dcph


4227: 2pmhs-24thiaz-bala-betabmph


4228: bim-24im-ala-betapy


4229: phhs-25thiaz-gly-betathio3


4230: ibhs-nme35pyr-gly-betahbcph


4231:tolhs-25oxaz-bala-betaol


4232: phhs-nme35pyr-bala-zdapch


4233: phhs-24thiaz-gly-betacph


4234: ibhs-24thioph-gly-betamethi


4235: 2pmhs-25thiaz-gly-betabpy


4236:phhs-24thioph-bala-zdapee


4237: phhs-oxadiaz-bala-betapyee


4238: ibhs-24thioph-gly-csdap


4239: tolhs-oxadiaz-bala-betapyr


4240: bim-25thiaz-bala-aspibua


4241:bhs-oxadiaz-gly-ibsdap


4242: bim-53pyrazo-leu-betadcph


4243: bhs-ithiadiaz-bala-betafu3


4244: tolhs-ithiadiaz-bala-betambiph


4245: ibhs-25methiaz-bala-betabdimo


4246:impy-25thiaz-gly-betathiobe


4247: bhs-oxadiaz-gly-betaanaphth


4248: tolhs-25thiaz-bala-betahdbph


4249: bhs-oxadiaz-bala-betathio3


4250: bhs-25fur-leu-betadcph


4251:2py-me25thioph-ala-betadcph


4252: phhs-24thioph-bala-betamethi


4253: 2pmhs-25oxaz-gly-psdap




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-141-
4254: bhs-oxadiaz-gly-betahmo


4255: phhs-nme35pyr-bala-aspbzla


4256: nmhs-25thiaz-gly-betadcph


4257: bhs-24thiaz-ala-betadmoph


4258: impy-25thiaz-bala-psdap


4259: bim-24oxaz-gly-betapy


4260: bhs-25oxaz-gly-suabu


4261: bim-25thioph-gly-betapy


4262: bim-25methiaz-bala-aspibua


104263: bhs-oxadiaz-gly-betahdcph


4264: ibhs-24thiaz-bala-betacthioph


4265: tolhs-24thiaz-gly-betaamibe


4266: tolhs-24thioph-bala-beta3quin


4267: ibhs-25thiaz-bala-betamesu


154268: phhs-oxadiaz-bala-zdapee


4269: ibhs-24thiaz-bala-betahmofu


4270: bhs-25methiaz-bala-betaet


4271: ibhs-25thiaz-gly-betaheph


4272: ibhs-24thiaz-bala-beta34meoph


204273: ibhs-nme35pyr-bala-betathioph


4274: bhs-25methiaz-bala-betafluo


4275: bim-25oxaz-ala-betapy


4276: phhs-24thioph-bala-betapbiph


4277: tolhs-24thiaz-gly-betadito


254278: bim-42oxaz-ala-psdap


4279: bhs-24thiophme-gly-zdap


4280: tolhs-24thiaz-bala-betadcphtb


4281: bhs-25thiaz-bala-betabpy


4282: phhs-me25oxaz-leu-betaph


304283: phhs-nme35pyr-gly-beta3quin


4284: bhs-oxadiaz-bala-betabthioph


4285: bim-nme35pyr-bala-aspibua


4286: bhs-25thiaz-bala-betaphethio


4287: ibhs-25thiaz-bala-betaoxaz


354288: bhs-nme35pyr-gly-zdaptb


4289: ibhs-25oxaz-bala-busu2be


4290: bhs-25methiaz-nmgly-betadmoph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 142 -
4291: tolhs-oxadiaz-bala-betameph


4292: bhs-24thiaz-gly-betabiph


4293: ibhs-25rnethiaz-bala-betapym


4294: tolhs-nme35pyr-gly-betathioph


4295:tolhs-25methiaz-bala-psdapch


4296: 2py-25thiaz-gly-asppha


4297: tolhs-24thiaz-bala-betahc


4298: 2pmhs-25thioph-gly-betapy


4299: ibhs-24thiaz-bala-betaph


4300:impy-25methiaz-bala-betamethi


4301: phhs-oxadiaz-gly-betathiobe


4302: ibhs-25thiaz-gly-betathioph


4303: gua-25thiaz-gly-betacthioph


4304: phhs-24thioph-gly-beta3quin


4305:phhs-oxadiaz-bala-betafph


4306: phhs-ithiadiaz-bala-betaoxope


4307; tolhs-25methiaz-bala-betahdcph


4308: bhs-24oxaz-leu-psdap


4309: ibhs-24thiaz-bala-betahdcph


4310:gua-24thiaz-gly-betahc


4311: phhs-24thiaz-bala-betadbph


4312: 2pmhs-25oxaz-gly-betatbuph


4313: ibhs-24thioph-bala-psdap


4314: bim-24thioph-bala-betapy


4315:tolhs-24thiaz-gly-beta13bendi


4316: pahs-25thiaz-gly-betapy


4317: thazep-24thiaz-bala-zdap


4318: phhs-24thioph-gly-betameph


4319; impy-24thioph-gly-betaipr


4320;2py-42nmeim-bala-betatrif


4321: phhs-24thiaz-gly-psdapee


4322: phhs-oxadiaz-gly-beta35dbph


4323: thpym-24thiaz-gly-betacbph


4324: phhs-24thiaz-bala-zdap


4325:ibhs-24thioph-bala-betapyee


4326: tolhs-ithiadiaz-gly-betaipro


4327: bhs-26py-gly-zdap




CA 02371604 2001-10-24
WO 00166618 f~CTIEP00103469
-143-
4328:phhs-ithiadiaz-bala-beta13bendi


4329:ibhs-25methiaz-gly-betaheph


4330:bhs-nme35pyr-gly-betacph


4331:bhs-thiadiaz-leu-zdap


4332:tolhs-24thiaz-gly-betafu3


4333:2py-ithiadiaz-leu-psdap


4334:thpym-42pym-gly-beta35dbph


4335:bhs-35fur-leu-zdap


4336:bim-me25thiaz-ala-psdap


4337:bim-thiadiaz-bala-betapy


4338:bhs-25thiaz-bala-betadcphee


4339:ibhs-ithiadiaz-bala-betadhbfu


4340:phhs-24thiaz-bala-betafu2


4341:bhs-oxadiaz-bala-aspibua


4342:tolhs-25thiaz-gly-betamethioph


4343:bhs-25oxaz-nmgly-betadhbfu


4344:3pmhs-24thiaz-bala-betapy


4345:2py-42pym-ala-zdap


4346:tolhs-24thioph-gly-betaoxaz


4347:phhs-25oxaz-bala-betaimid


4348:bim-25oxaz-bala-aspibua


4349:phhs-nme35pyr-gly-betathiobe


4350:ibhs-24thioph-bala-betahc


4351:bhs-nme35pyr-bala-zdapee


4352:2py-24thiaz-bala-betaoxope


4353:bhs-25thiaz-ala-betamesu


4354:phhs-25methiaz-bala-betah35dc


4355:bhs-25oxaz-gly-betacbph


4356:tolhs-25thiaz-gly-beta3quin


4357:bhs-oxadiaz-gly-betadbph


4358:tolhs-25oxaz-bala-betameph


4359:phhs-24thiaz-gly-beta4bph


4360:2py-me25thiaz-leu-betadcph


4361:2py-nme35pyr-gly-betapy


4362:bhs-25oxaz-bala-betacph


4363:bhs-25methiaz-bala-betal3bendi


4364:dhim-25thiaz-gly-psdap




CA 02371604 2001-10-24
WO 00/66618 PCTIEP00103469
- 144 -
4365:2py-42nmeim-bala-betadbph


4366:bhs-ithiadiaz-gly-betapytb


4367:phhs-ithiadiaz-bala-betatos


4368:tolhs-oxadiaz-bala-betafu3


4369:2py-24thiaz-gly-aspbzla


4370:bhs-25oxaz-bala-betaibph


4371:ibhs-ithiadiaz-gly-betahb


4372:ibhs-25thiaz-bala-betadcph


4373:ibhs-24thiaz-gly-beta23meoph


104374:tolhs-nme35pyr-bala-betatbuph


4375:bhs-24thioph-bala-betapyr


4376:ibhs-nme35pyr-gly-betahcbph


4377:bhs-53pyrazo-gly-psdap


4378:pahs-24thiaz-bala-betameph


154379:ibhs-oxadiaz-gly-betabpy


4380:tolhs-nme35pyr-gly-betatrif


4381:phhs-25thiaz-bala-betabdimo


4382:ibhs-25oxaz-bala-betaheph


4383:tolhs-24thiaz-gly-betaibph


204384:2py-triaz-ala-betapy


4385:bhs-25methiaz-gly-betadmph


4386:phhs-25thiaz-bala-betaibph


4387:ibhs-25thiaz-giy-betahcbph


4388:phhs-oxadiaz-bala-beta35dbph


254389:bim-nme35pyr-ala-psdap


4390:phhs-25oxaz-bala-betahmofu


4391:bim-25thiaz-bala-betatos


4392:ibhs-25oxaz-bala-psdapee


4393:hts-24thioph-gly-betapy


304394:bhs-25methiaz-bala-beta4bph


4395:bhs-me25thiaz-gly-betapy


4396:bhs-25methiaz-gly-betaibph


4397:bhs-25oxaz-bala-betaanaphth


4398:bhs-25thiaz-gly-betaphethio


354399:phhs-24thiaz-bala-beta23meoph


4400:tolhs-24thiaz-gly-csdap -


4401:phhs-oxadiaz-gly-betaol




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 145
4402:ibhs-nme35pyr-gly-aspibua


4403:pahs-25oxaz-gly-betapy


4404:bhs-oxadiaz-bala-beta13bendi


4405:phhs-24thioph-gly-betatbph


4406:ibhs-25thiaz-gly-betaimid


4407:bhs-oxadiaz-nmgly-betabnaphth


4408:phhs-25oxaz-gly-betainyl


4409:bim-ithiadiaz-gly-aspbzla


4410:tolhs-24thioph-gly-betacph


104411:bhs-nme35pyr-gly-betaphethio


4412:2py-42oxaz-gly-betapy


4413:ibhs-24thiaz-bala-betamesu


4414:bhs-24thioph-bala-betahb


4415:tolhs-oxadiaz-bala-betahph


154416:bhs-nme35pyr-bala-betapytb


4417:tolhs-24thiaz-gly-betahc


4418:bim-35thioph-leu-betadcph


4419:bhs-25methiaz-bala-betahmo


4420:bim-me25thioph-gly-beta34meoph


204421:4pmhs-25thiaz-gly-betapy


4422:phhs-25thiaz-bala-betahmph


4423:phhs-25methiaz-gly-aspbzla


4424:gua-24thiaz-gly-betacthioph


4425:thpym-25thioph-gly-betacbph


254426:dhim-25thiaz-gly-betapy


4427:ibhs-25methiaz-bala-zdap


4428:bhs-25methiaz-bala-busu2be


4429:bim-24thioph-gly-betahmph


4430:phhs-nme35pyr-gly-betaipro


304431:bhs-me24oxaz-ala-beta34meoph


4432:bhs-nme35pyr-ala-betacthioph


4433:bim-42oxaz-afa-betapy


4434:bhs-24thioph-gly-betadmph


4435:phhs-25methiaz-gly-betahbcph


354436:tolhs-24thioph-gly-betathiobe


4437:ibhs-25oxaz-bala-betaoxaz


4438:ibhs-nme35pyr-bala-betameph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-146
4439: tolhs-ithiadiaz-gly-betapbiph


4440: bim-24thioph-bala-aspbzla


4441: 2py-nme35pyr-leu-betapy


4442: dhthi-24oxaz-gly-betapy


4443: tolhs-24thioph-gly-betadmph


4444: phhs-25thiaz-bala-psdaptb


4445: 2py-me25oxaz-gly-beta34meoph


4446: tolhs-oxadiaz-gly-betapyr


4447: bhs-24thiaz-gly-betamethi


104448: bhs-24thiaz-bala-betaph


4449: bhs-oxadiaz-bala-betahdcph


4450: gua-25thioph-gly-betahcbph


4451: 2py-52thiaz-gly-betainyl


4452: tolhs-oxadiaz-bala-betacthioph


154453: 2py-25methiaz-gly-betadcph


4454: bhs-oxadiaz-gly-betatrif


4455: tolhs-24thioph-gly-betabmh


4456: tolhs-25methiaz-bala-betadcph


4457: bim-triaz-ala-betadcph


204458: bhs-nme35pyr-gly-beta3quin


4459: phhs-24thioph-gly-betahb


4460: phhs-25thiaz-gly-betafbph


4461: impy-42nmeim-bala-betadtrif


4462: phhs-24thiaz-bala-suabu


254463: tolhs-24thioph-bala-betapyr


4464: bhs-25thiaz-ala-betadmoph


4465: bhs-25thiaz-bala-betah35dc


4466: hts-24thiaz-gly-betapy


4467: phhs-ithiadiaz-bala-betahdcph


304468: ibhs-24thiaz-bala-betamethioph


4469: bim-oxadiaz-gly-psdap


4470: bim-oxadiaz-leu-zdap


4471: ibhs-oxadiaz-gly-ibsdap


4472: tolhs-me24thioph-leu-beta34meoph


354473: phhs-ithiadiaz-bala-aspaba


4474: ibhs-oxadiaz-bala-betah35dc


4475: phhs-25methiaz-bala-betapych




CA 02371604 2001-10-24
WO OOI66618 PCTIEP00103469
- 147 -
4476:phhs-24thioph-gly-betabph


4477:impy-25thiaz-gly-betambiph


4478:bhs-25thiaz-gly-betafu2


4479:ibhs-oxadiaz-gly-psdapee


4480:bhs-24thioph-bala-betaimid


4481:tolhs-24thioph-gly-psdap


4482:ibhs-oxadiaz-bala-psdapch


4483.phhs-24thiaz-gly-betabthioph


4484:bim-26py-gly-betadcph


4485:bhs-24thioph-bala-betahmph


4486:ibhs-25oxaz-gly-betafphe


4487:bhs-25oxaz-gly-betaipr


4488:tolhs-24thiaz-gly-betahdcph


4489:gua-24oxaz-gly-betahmofu


4490:tolhs-24thioph-bala-betacph


4491:tolhs-24thioph-gly-beta34meoph


4492:bhs-oxadiaz-bala-beta35dbph


4493:phhs-ithiadiaz-gly-betaet


4494:bim-24thioph-bala-csdap


4495:bhs-25methiaz-gly-zdaptb


4496:bhs-nme35pyr-bala-betaphethio


4497:ibhs-24thiaz-gly-betathioph


4498:tolhs-24thiaz-bala-betapych


4499:tolhs-oxadiaz-gly-betadcphch


4500:bhs-ithiadiaz-leu-betadcph


4501:phhs-nme35pyr-gly-betaimid


4502:tolhs-24thiaz-gly-betahni


4503:2py-26py-gly-csdap


4504:bhs-triaz-bala-zdap


4505:tolhs-25oxaz-bala-betapyee


4506:phhs-oxadiaz-gly-betabediox


4507:bhs-25thiaz-gly-betapy


4508:tolhs-ithiadiaz-bala-beta23meoph


4509:gua-26py-gly-betambiph


4510:2pmhs-24thioph-gly-betameph


4511:phhs-oxadiaz-bala-betaipro


4512:tolhs-nme35pyr-gly-betaimid




CA 02371604 2001-10-24
WO 00166618 PCTIEP00I03469
-148
4513.tolhs-nme35pyr-gly-beta34dcph


4514:phhs-25thiaz-bala-betabpy


4515:2py-24thioph-gly-psdap


4516:ibhs-24thioph-gly-betadcphch


4517:phhs-25methiaz-gly-betafphe


4518:tolhs-25methiaz-bala-betambiph


4519:tolhs-24thiaz-bala-betatrif


4520:phhs-oxadiaz-gly-betahc


4521:bim-oxadiaz-bala-zdap


4522:phhs-25methiaz-bala-betahb


4523:phhs-25methiaz-gly-zdapee


4524:bim-25thiaz-gly-betadmph


4525:phhs-25oxaz-gly-betatbuph


4526:phhs-25oxaz-gly-zdapee


4527:bhs-nme35pyr-ala-betahmph


4528:2py-me24thiaz-ala-zdap


4529:tolhs-ithiadiaz-bala-betahdbph


4530:ibhs-24thiaz-gly-zdapee


4531:tolhs-25methiaz-bala-betadcphee


4532:phhs-nme35pyr-bala-betaanaphth


4533:bhs-nme35pyr-bala-betaanaphth


4534:tolhs-nme35pyr-gly-betathiome


4535:ibhs-25methiaz-gly-betacthioph


4536:bhs-24thioph-gly-betah35dc


4537:bim-24oxaz-ala-psdap


4538:ibhs-oxadiaz-gly-betadcphee


4539:tolhs-oxadiaz-bala-betaol


4540:ibhs-ithiadiaz-bala-aspbzla


4541:2 py-26 py-ala-zd a
p


4542:tolhs-oxadiaz-gly-betafu3


4543:bhs-me24thioph-leu-zdap


4544:dhpyrr-24oxaz-gly-betameph


4545:bhs-24thiaz-gly-psdap


4546:tolhs-oxadiaz-bala-betambiph


4547:phhs-24thioph-gly-betafphe


4548:tolhs-ithiadiaz-bala-betacbph


4549:phhs-24thiaz-bala-betadcphee




CA 02371604 2001-10-24
WU 00/66618 PCTlEP00103469
-149
4550:ibhs-25oxaz-gly-betampy


4551:phhs-oxadiaz-bala-aspaba


4552:bim-25oxaz-bala-betapyr


4553:phhs-25oxaz-bala-beta35dbph


4554:ibhs-25thiaz-bala-ibsdap


4555:ibhs-nme35pyr-gly-betaoxope


4556:tolhs-oxadiaz-gly-betabpy


4557:phhs-nme35pyr-bala-beta3quin


4558:tolhs-nme35pyr-gly-betamesu


104559:bhs-24thiaz-bala-betacph


4560:ibhs-nme35pyr-bala-betaheph


4561:2pmhs-24thioph-bala-beta4bph


4562:bhs-thiadiaz-bala-betapy


4563:phhs-nme35pyr-bala-betadbph


154564:2py-26py-gly-betapy


4565:bim-me24thioph-ala-psdap


4566:tolhs-me24thioph-ala-betaph


4567:phhs-24thioph-bala-betacthioph


4568:phhs-ithiadiaz-bala-betapym


204569:bhs-24thiaz-bala-betatrif


4570:phhs-25thiaz-bala-betaimid


4571:bhs-24thiaz-bala-betaet


4572:2pmhs-24thioph-bala-beta13bendi


4573:2py-me24thiaz-leu-psdap


254574:tolhs-24thioph-bala-betaph


4575:ibhs-25oxaz-gly-betahmo


4576:phhs-nme35pyr-bala-betapytb


4577:tolhs-ithiadiaz-gly-betadmph


4578:tolhs-ithiadiaz-gly-betahmofu


304579:phhs-24thioph-bala-betahcbph


4580:phhs-25rnethiaz-gly-beta4bph


4581:phhs-nme35pyr-bala-betafluo


4582:tolhs-24thiaz-gly-betah35dc


4583:ibhs-25methiaz-gly-betaet


354584:ibhs-25methiaz-bala-betabmph


4585:tolhs-25oxaz-gly-betahph


4586:bhs-ithiadiaz-nmgly-betameph




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 150
4587: ibhs-ithiadiaz-bala-ibsdap


4588: 2pmhs-25thiaz-bala-zdap


4589: bhs-25oxaz-gly-beta3quin


4590: ibhs-ithiadiaz-gly-psdap


4591: tolhs-ithiadiaz-bala-betathio3


4592: phhs-24thiaz-bala-betahdbph


4593: phhs-25methiaz-bala-betafu2


4594: bhs-nme35pyr-bala-betafphe


4595: ibhs-24thioph-gly-betapym


104596: toihs-25thiaz-gly-csdap


4597: ibhs-nme35pyr-gly-betafphe


4598: gua-24thiaz-gly-betabediox


4599: bim-25thioph-gly-betameph


4600: 2py-25oxaz-gly-zdap


154601: ibhs-ithiadiaz-gly-betabediox


4602: bhs-25oxaz-gly-betabediox


4603: ibhs-25methiaz-bala-betah35dc


4604: bhs-24thiazme-ala-betameph


4605: gua-24thiaz-gly-betaimid


204606: bhs-25thiaz-gly-betaipro


4607: ibhs-25methiaz-bala-betafu2


4608: bhs-24thioph-bala-psdapee


4609: phhs-24thiaz-gly-betah35dc


4610: bhs-52thiaz-ala-psdap


254611: ibhs-25oxaz-gly-betapyee


4612: ibhs-25thiaz-gly-psdap


4613: nmhs-25oxaz-bala-zdap


4614: tolhs-24thiaz-gly-betabdimo


4615: bhs-25thiaz-afa-beta23meoph


304616: gua-24thiaz-gly-betampy


4617: tolhs-ithiadiaz-gly-betatrif


4618: bhs-42pym-ala-betameph


4619: bhs-25methiaz-ala-betacthioph


4620: phhs-oxadiaz-bala-betadcphtb


354621: bhs-24thioph-bala-betafu3


4622: tolhs-25oxaz-bafa-betafu2


4623: bhs-25oxaz-bala-betaamibe




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
- 151
4624: bim-25methiaz-gly-betadcph


4625: gua-24thiaz-gly-betacph


4626: bhs-24thiaz-nmgly-beta34meoph


4627: tolhs-me25thioph-bala-betaph


4628: bhs-nme35pyr-gly-betafluo


4629: ibhs-25thiaz-bala-betahmph


4630: phhs-25oxaz-bala-betaph


4631: tolhs-me24thioph-ala-beta34meoph


4632: bhs-nme35pyr-gly-beta35dbph


104633: dimethpym-24thiaz-gly-betadcph


4634: ibhs-25methiaz-bala-betaimid


4635: ibhs-24thioph-bala-betabthioph


4636: tolhs-nme35pyr-bala-betapyee


4637: hyd-25thiaz-gly-betainyl


154638: tolhs-25oxaz-bala-betapyr


4639: bhs-ithiadiaz-gly-betahdcph


4640: bhs-oxadiaz-bala-betadmoph


4641: phhs-me25oxaz-ala-betadcph


4642: phhs-25methiaz-bala-betameph


204643: bhs-24thiaz-gly-betahc


4644: bhs-me24thioph-leu-betapy


4645: ibhs-25methiaz-bala-betahc


4646: phhs-me24oxaz-ala-betaph


4647: phhs-24thiaz-gly-betahmofu


254648: bhs-ithiadiaz-ala-betadmoph


4649: dimethpym-25thioph-gly-betahdcph


4650: bim-25methiaz-bala-betadcph


4651: bhs-24thioph-nmgly-betadmoph


4652: tolhs-25methiaz-bala-betatbuph


304653: phhs-24thiaz-gly-betathiome


4654: phhs-25oxaz-gly-psdaptb


4655: ibhs-ithiadiaz-bala-betapbiph


4656: ibhs-nme35pyr-bala-betaet


4657: tolhs-25thiaz-bala-zdaptb


354658: bhs-25thiaz-gly-beta3quin


4659: bim-52thiaz-ala-betainyl


4660: bhs-24thioph-ala-betadito




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
-152
4661: 2py-42nmeim-ala-psdap


4662: phhs-25thiaz-gly-beta3quin


4663: tolhs-oxadiaz-bala-beta13bendi


4664: ibhs-25methiaz-gly-betabmph


4665: ibhs-25methiaz-bala-beta23meoph


4666: bhs-24thioph-gly-betahb


4667: tolhs-oxadiaz-gly-betafluo


4668: gua-24thiaz-gly-betabph


4669: ibhs-25oxaz-gly-aspaba


104670: bhs-25oxaz-ala-zdap


4671: tolhs-25thiaz-bala-betahni


4672: bim-42nmeim-gly-betamesu


4673: dhthi-24thiaz-gly-betapy


4674: phhs-nme35pyr-bala-psdap


154675: ibhs-25oxaz-gly-betatos


4676: bhs-nme35pyr-gly-betapyee


4677: 2py-24thiaz-bala-psdap


4678: tolhs-oxadiaz-gly-betah35dc


4679: tolhs-24thioph-bala-betapytb


204680: gua-24thiaz-gly-beta34dcph


4681: phhs-24thioph-bala-zdap


4682: bhs-ithiadiaz-bala-betahni


4683: gua-25thiaz-gly-betampy


4684: phhs-nme35pyr-bala-beta34dcph


254685: tolhs-nme35pyr-bala-betahph


4686: bhs-24thioph-ala-betameph


4687: phhs-25thiaz-bala-betabediox


4688: ibhs-24thioph-gly-betahmph


4689: tolhs-nme35pyr-bala-betahmph


304690: bhs-25oxaz-gly-betampy


4691: bhs-ithiadiaz-bala-beta4bph


4692: phhs-25methiaz-gly-betadtrif


4693: bhs-me25thiaz-gly-zdap


4694: phhs-25oxaz-gly-busu2be


354695: bhs-nme35pyr-bala-betafu2


4696: ibhs-25methiaz-bala-betathiobe


4697: ibhs-25oxaz-gly-betabdimo




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 153
4698: bim-ithiadiaz-ala-psdap


4699: tolhs-oxadiaz-gly-betaimid


4700: ibhs-24thioph-gly-betaftrif


4701: 2py-me25thiaz-ala-betadcph


4702: ibhs-25methiaz-bala-suabu


4703: bhs-24thiaz-bala-betafu3


4704: ibhs-25thiaz-gly-beta13bendi


4705: bim-53pyrazo-gly-zdap


4706: bhs-nme35pyr-bala-betapych


4707:bhs-25methiaz-bala-betahdcph


4708: phhs-24thiaz-gly-betaphethio


4709: ibhs-25methiaz-gly-betahmofu


4710: bhs-25oxaz-bala-betahmofu


4711: phhs-25methiaz-gly-betafbph


4712:ibhs-24thiaz-gly-betamethi


4713: ibhs-25methiaz-gly-psdap


4714: phhs-nme35pyr-bala-betadmph


4715: phhs-oxadiaz-gly-betal3bendi


4716: tolhs-24thiaz-bala-betadcphee


4717:bhs-ithiadiaz-gly-betatos


4718: ibhs-25oxaz-gly-betaphethioa


4719: ibhs-nme35pyr-gly-beta4bph


4720: bhs-oxadiaz-nmgly-betahph


4721: tolhs-ithiadiaz-bala-betahcbph


4722:bhs-25thiaz-gly-betabdimo


4723: bhs-24thiaz-ala-ibsdap


4724: phhs-25methiaz-bala-betafph


4725: bhs-ithiadiaz-gly-betambiph


4726: gua-25methiaz-bala-betadcph


4727:bhs-nme35pyr-ala-betathioph


4728: ibhs-25thiaz-gly-betadcphtb


4729: bhs-nme35pyr-bala-betahni


4730: ibhs-24thiaz-bala-betaamibe


4731: bhs-me24thiaz-ala-zdap


4732:phhs-24thiaz-gly-betaph


4733: ibhs-25methiaz-gly-betahb


4734: bhs-24thiaz-gly-betatrif




CA 02371604 2001-10-24
WO 00166618 PCTIEP00103469
- 154 -
4735; bhs-25oxaz-gly-aspbzla


4736: phhs-nme35pyr-gly-betadmoph


4737: bim-25oxaz-ala-zdap


4738: gua-24thiaz-gly-betaibph


4739: ibhs-nme35pyr-gly-betapyee


4740: dhim-25thiaz-gly-zdap


4741: tolhs-25methiaz-bala-beta3quin


4742: tolhs-me24thioph-bala-betadcph


4743: ibhs-oxadiaz-bala-betaomebendi


104744: tolhs-25thiaz-gly-betaheph


4745: bhs-53pyrazo-leu-betapy


4746: bim-25fur-bala-psdap


4747: bim-25thiaz-leu-psdap


4748: bim-42nmeim-bala-zdap


154749: gua-26py-gly-betabmph


4750: bim-me25thiaz-leu-beta34meoph


4751: bim-oxadiaz-bala-asppha


4752: bhs-24im-gly-betapy


4753: tolhs-25thiaz-bala-betadtrif


204754: phhs-25methiaz-bala-betapyr


4755: 2py-24th iaz-gly-betadito


4756: ibhs-24thioph-gly-betadmph


4757: phhs-oxadiaz-bala-psdaptb


4758: bhs-me24thioph-ala-betapy


254759: tolhs-me25thiaz-leu-psdap


4760: tolhs-24thiaz-bala-beta35dbph


4761: pahs-24thiaz-gly-betapy


4762: dhim-25thioph-ala-betapy


4763: bhs-24thioph-bala-betahmo


304764: bhs-me24oxaz-ala-betaph


4765: ibhs-25oxaz-gly-betatbuph


4766: thpym-26py-gly-betainyl


4767: bhs-25methiaz-bala-beta23meoph


4768: phhs-24thiaz-bala-betabpy


354769: 2py-53pyrazo-ala-zdap


4770: tolhs-25methiaz-bala-betabpy


4771: phhs-oxadiaz-bala-betahdcph




CA 02371604 2001-10-24
WO 00!66618 PCTIEP00103469
-155
4772; bhs-24thioph-gly-betamethioph
4773: phhs-ithiadiaz-gly-betahdbph
4774: phhs-25thiaz-gly-zdaptb
4775: bhs-ithiadiaz-gly-betabthioph
4776: bhs-24thioph-bala-beta34dcph
4777: bhs-24thiaz-gly-betahmofu
4778: bhs-25thiaz-bala-betadcphch
4779: tolhs-25methiaz-gly-betatbuph
4780: ibhs-24thiaz-bafa-aspaba
4781: thpym-25thiaz-gly-beta35dbph
4782: gua-26py-gly-betacph
4783: ibhs-oxadiaz-bala-betadcph
4784: ibhs-24thiaz-gly-betainyl
4785: bim-24py-gly-zdap
4786: 2py-52thiaz-ala-zdap
4787: phhs-24thiaz-gly-beta13bendi
4788: ibhs-ithiadiaz-bala-busu2be
4789: bhs-35thioph-ala-betadcph
4790: phhs-25oxaz-bala-beta34dcph
4791: bhs-24thiaz-gly-betabthioph
4792: phhs-24thiaz-bala-betaamibe
4793: bhs-24thioph-gly-betadcph
4794: tolhs-ithiadiaz-gly-betatbuph
4795: ibhs-nme35pyr-bala-betaol
4796: tolhs-25methiaz-gly-betacbph
4797: phhs-24thiaz-bala-betadmph
4798: tolhs-24thioph-bala-betaipro
4799: bhs-25thiaz-ala-betaipro
4800: bhs-25thiaz-bala-betaamibe
4801: tolhs-24thiaz-bala-betambiph
4802: bhs-triaz-gly-betapy
4803: bhs-25oxaz-gly-betathioph
4804: bhs-25oxaz-bala-betafu3
4805: ibhs-25oxaz-bala-zdapch
4806: bhs-35thioph-bala-betadcph
4807: phhs-oxadiaz-bala-betadcphch
4808: phhs-ithiadiaz-bala-asppha


CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-156
4809: bim-me24thiaz-gly-beta34meoph


4810: ibhs-25methiaz-gly-betaftrif


4811: 3pmhs-25methiaz-bala-betapy


4812: ibhs-25thiaz-gly-betadhbfu


4813: tolhs-24thioph-gly-betaipr


4814: ibhs-25thiaz-gly-betabmph


4815: bhs-25methiaz-bala-zdaptb


4816: bhs-25thiaz-ala-betaheph


4817: bhs-ithiadiaz-bala-betahmph


104818: bim-42pym-gly-betadcph


4819: bhs-25methiaz-gly-psdap


4820: phhs-25oxaz-gly-betacph


4821: bhs-nme35pyr-gly-zdap


4822: bhs-oxadiaz-bala-beta34meoph


154823: tolhs-me24thiaz-leu-betapy


4824: ibhs-25oxaz-bala-betahc


4825; bhs-25methiaz-bala-betahmph


4826: ibhs-24thiaz-bala-zdapch


4827: tolhs-25methiaz-gly-betadmph


204828: 2py-26py-gly-betadcph


4829: dhim-24thiaz-ala-betadcph


4830: bhs-24thiaz-ala-betacph


4831: phhs-ithiadiaz-bala-aspibua


4832: bhs-25thiaz-ala-betahph


254833: phhs-24thioph-bala-betahdcph


4834: bhs-24thiaz-nmgly-betathioph


4835: tolhs-ithiadiaz-gly-asppha


4836: ibhs-24thioph-gly-betaphethioa


4837: phhs-24thiaz-bala-psdap


304838: phhs-25oxaz-bala-betathio3


4839: ibhs-24thioph-gly-betatbuph


4840: ibhs-nme35pyr-gly-betadcphee


4841: phhs-me24thiaz-bala-zdap


4842: ibhs-24thioph-bala-betahdbph


354843: tolhs-25thiaz-bala-betaipr


4844: gua-26py-gly-betabenfu


4845: ibhs-oxadiaz-bala-betadtrif




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-157
4846: dhim-24thiaz-gly-betahcbph


4847: dhim-25thiaz-ala-betadcph


4848: tolhs-24thioph-gly-betabnaphth


4849: bhs-24thiaz-bala-betahmo


4850: ibhs-oxadiaz-bala-betadbph


4851: phhs-25methiaz-bala-betahmo


4852: ibhs-25methiaz-gly-betapy


4853: tolhs-25methiaz-gly-zdapch


4854: phhs-25oxaz-bala-betahcbph


104855: tolhs-nme35pyr-bala-betaet


4856: tolhs-ithiadiaz-bala-betapytb


4857: nmhs-24thiaz-gly-betadcph


4858: phhs-25thiaz-gly-betaibph


4859: tolhs-24thiaz-bala-betabph


154860: tolhs-25oxaz-bala-betaanaphth


4861: bhs-24thioph-bala-betabthioph


4862: phhs-oxadiaz-gly-betadmoph


4863: bim-me25oxaz-ala-psdap


4864: ibhs-25methiaz-bala-betahdbph


204865: bhs-24thioph-ala-betacph


4866: ibhs-24thioph-bala-betadhbfu


4867: ibhs-nme35pyr-bala-betaipr


4868: bim-25oxaz-bala-zdap


4869: bim-42nmeim-leu-zdap


254870: ibhs-oxadiaz-gly-betahdbph


4871: phhs-me24oxaz-ala-beta34meoph


4872: bhs-oxadiaz-bala-betahmo


4873: phhs-24thiaz-bala-betadhbfu


4874: bhs-25fur-bala-zdap


304875: tolhs-me25thioph-gly-betapy


4876: ibhs-25thiaz-gly-betafph


4877: 2py-me24thiaz-bala-betapy


4878: phhs-ithiadiaz-bala-beta4bph


4879: phhs-me25thioph-gly-zdap


354880: ibhs-24thioph-bala-betapytb


4881: dhim-26py-gly-betadcph


4882: phhs-25methiaz-gly-betaoxope




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-158-
4883: bhs-25thiaz-bala-betapy


4884: bim-25thiaz-gly-betapbiph


4885: phhs-25thiaz-bala-betahb


4886: bhs-ithiadiaz-gly-beta3quin


4887: ibhs-25thiaz-gly-betacthioph


4888: bhs-25methiaz-bala-ibsdap


4889: bim-42pym-ala-betainyl


4890: bhs-24thiaz-bala-betapym


4891: bim-25thiaz-bala-csdap


104892: bhs-25oxaz-gly-betamesu


4893: bhs-24thioph-ala-betahmph


4894: ibhs-25methiaz-bala-betahcbph


4895: tolhs-ithiadiaz-bala-psdapch


4896: tolhs-24thiaz-gly-betampy


154897: bhs-triaz-bala-psdap


4898: bhs-nme35pyr-gly-betabnaphth


4899: phhs-oxadiaz-bala-betabnaphth


4900: tolhs-25thiaz-bala-betamethioph


4901: tolhs-oxadiaz-gly-betadbph


204902: tolhs-nme35pyr-bala-betadhbfu


4903: bhs-24thiaz-ala-betaanaphth


4904: ibhs-25thiaz-gly-betadcphch


4905: bhs-oxadiaz-gly-betapbiph


4906: ibhs-ithiadiaz-gly-betampy


254907: tolhs-25thiaz-gly-aspaba


4908: bhs-nme35pyr-bala-betabdimo


4909: tolhs-oxadiaz-gly-betadcphtb


4910: tolhs-oxadiaz-bala-beta3quin


4911: bim-oxadiaz-bala-psdap


304912: phhs-25methiaz-bala-beta34meoph


4913: phhs-24thiaz-gly-betaftrif


4914: bhs-nme35pyr-gly-betacbph


4915: ibhs-oxadiaz-bala-suabu


4916: bhs-triaz-bala-betadcph


354917: 2py-24oxaz-leu-betapy


4918: dhim-42pym-ala-betainyl


4919: phhs-25oxaz-gly-betaftrif




CA 02371604 2001-10-24
W000166618 PCTlEP00/03469
-159
4920: tolhs-25thiaz-bala-betaanaphth


4921: bhs-thiadiaz-bala-psdap


4922: tolhs-24thioph-bala-betainyl


4923: tolhs-25oxaz-gly-betathioph


4924: bhs-42pym-ala-betapy


4925: 2py-26py-gly-beta23meoph


4926: phhs-ithiadiaz-gly-betahph


4927: phhs-25methiaz-gly-betapym


4928: ibhs-25methiaz-bala-betacthioph


104929: bhs-24thiaz-gly-betabenfu


4930: tolhs-25thiaz-bala-betaphethioa


4931: bhs-25thiaz-gly-ibsdap


4932: ibhs-25thiaz-bala-betainyl


4933: tolhs-24thioph-bala-psdaptb


154934: ibhs-24thiaz-bala-betadhbfu


4935: bhs-nme35pyr-bala-betaoxope


4936: tolhs-25methiaz-gly-beta13bendi


4937: ibhs-24thiaz-gly-beta34dcph


4938: bim-me24oxaz-ala-zdap


204939: phhs-nme35pyr-bala-betapbiph


4940: dhim-26py-ala-betadcph


4941: phhs-25methiaz-gly-betacthioph


4942: 2py-42nmeim-bala-zdap


4943: ibhs-25thiaz-gly-betahbcph


254944: ibhs-25thiaz-gly-betacph


4945: ibhs-25oxaz-gly-betacbph


4946: tolhs-25thiaz-bala-betadcph


4947: dhim-24oxaz-gly-betameph


4948: bhs-nme35pyr-gly-betatrif


304949: bhs-24thioph-bala-betahph


4950: bhs-nme35pyr-bala-aspibua


4951: bhs-25thiaz-gly-betamesu


4952: bim-me24oxaz-bala-betaph


4953: bhs-25oxaz-bala-betahb


354954: bim-ithiadiaz-ala-zdap


4955: phhs-oxadiaz-bala-betabmph


4956: bhs-oxadiaz-ala-betadito




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-160
4957:phhs-ithiadiaz-bala-betatbuph


4958:bhs-25oxaz-nmgly-betaipro


4959:2py-25fur-leu-psdap


4960:bhs-ithiadiaz-gly-asppha


4961:ibhs-25methiaz-gly-psdapch


4962:tolhs-25thiaz-gly-psdap


4963:bhs-oxadiaz-bala-betaet


4964:bhs-24thioph-bala-betamethioph


4965:bim-24thioph-gly-aspibua


4966:phhs-me25thioph-ala-betaph


4967:tolhs-nme35pyr-gly-ibsdap


4968:ibhs-24thioph-bala-beta23meoph


4969:tolhs-oxadiaz-bala-betadhbfu


4970:2py-25thiaz-gly-betadito


4971:phhs-ithiadiaz-gly-betahc


4972:phhs-24thioph-bala-betahbcph


4973:bhs-25methiaz-bala-betah35dc


4974:gua-25thioph-gly-betacph


4975:phhs-oxadiaz-gly-beta23meoph


4976:ibhs-24thioph-gly-betah35dc


4977:phhs-24thioph-gly-betaanaphth


4978:bim-24thiaz-bala-csdap


4979:2py-24thiaz-gly-betameph


4980:tolhs-24thioph-bala-betambiph


4981:2py-24im-leu-betadcph


4982:tolhs-nme35pyr-bala-betah35dc


4983:bhs-25oxaz-gly-ibsdap


4984:ibhs-25methiaz-gly-ibsdap


4985:tolhs-ithiadiaz-gly-betameph


4986:bhs-24thiaz-bala-betainyl


4987:bim-me25thiaz-bala-betadcph


4988:tolhs-25methiaz-bala-beta35dbph


4989:bhs-me25oxaz-gly-betaph


4990:phhs-25thiaz-gly-betadhbfu


4991:cima-42nmeim-bala-betapy


4992:phhs-24thiaz-bala-betabthioph


4993:bim-24thioph-leu-psdap




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-161-
4994:tolhs-me25oxaz-bala-beta34meoph


4995:ibhs-oxadiaz-bala-betainyl


4996:ibhs-ithiadiaz-bala-betaipr


4997:tolhs-nme35pyr-bala-betatos


4998:3pmhs-25thioph-gly-betapy


4999:2py-25thiaz-gly-aspaba


5000:bim-25methiaz-leu-betapy


5001:bim-24thiaz-bala-betadcph


5002:bhs-24thioph-gly-ibsdap


5003:2py-53pyrazo-gly-psdap


5004:ibhs-24thioph-gly-betaamibe


5005:tolhs-me24thiaz-gly-betapy


5006:bhs-52thiaz-gly-betameph


5007:ibhs-ithiadiaz-bala-betathioph


5008:ibhs-25thiaz-gly-betadmph


5009:bim-24im-gly-zdap


5010:ibhs-24thioph-bala-psdaptb


5011:bim-24thioph-bala-aspibua


5012:bhs-ithiadiaz-nmgly-betahmph


5013:bhs-25thiaz-bala-betainyl


5014:phhs-25methiaz-gly-betacbph


5015:bim-25thiaz-gly-betainyl


5016:phhs-24thioph-gly-betabediox


5017:phhs-oxadiaz-gly-betabnaphth


5018:ibhs-nme35pyr-gly-betabediox


5019:phhs-25thiaz-bala-betah35dc


5020:tolhs-nme35pyr-bala-beta34meoph


5021:phhs-me24thiaz-gly-psdap


5022:phhs-24thioph-bala-betabdimo


5023:tolhs-nme35pyr-gly-betaipro


5024:ibhs-25thiaz-gly-betaomebendi


5025:phhs-25oxaz-gly-betabmph


5026:dhim-26py-ala-betainyl


5027:thpym-26py-gly-betacbph


5028:ibhs-24thiaz-bala-betapytb


5029;ibhs-25thiaz-bala-betaimid


5030:ibhs-ithiadiaz-gly-betaol




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-162-
5031:ibhs-oxadiaz-bala-beta34dcph


5032:phhs-me25oxaz-gly-betaph


5033:tolhs-24thioph-bala-betafphe


5034:ibhs-24thioph-bala-betaftrif


5035:bim-42pym-ala-betapy


5036:bhs-nme35pyr-ala-betacph


5037:tolhs-nme35pyr-gly-betabenfu


5038:bim-42oxaz-ala-zdap


5039:ibhs-25oxaz-bala-betampy


5040:phhs-25thiaz-gly-betafphe


5041:dhim-26py-gly-beta34meoph


5042:ibhs-24thiaz-gly-betathiome


5043:bim-me24thioph-bala-betapy


5044:bim-24im-bala-zdap


5045:bhs-ithiadiaz-bala-betahbcph


5046:2py-25thiaz-gly-betadcph


5047:bim-me25oxaz-bala-betadcph


5048:phhs-25methiaz-bala-betathiobe


5049:ibhs-25oxaz-bala-beta3quin


5050:phhs-oxadiaz-bala-beta34meoph


5051:gua-42pym-gly-betabthioph


5052:bhs-35thioph-bala-betapy


5053:2py-42pym-gly-betainyl


5054:phhs-ithiadiaz-gly-beta4bph


5055:bhs-24thioph-bala-betahdcph


5056:ibhs-25methiaz-bala-betahni


5057:bim-25methiaz-leu-psdap


5058:tolhs-me25oxaz-ala-beta34meoph


5059:ibhs-25thiaz-bala-betampy


5060:phhs-25methiaz-gly-betaoxaz


5061:2pmhs-42pym-gly-betainyl


5062:tolhs-nme35pyr-gly-betapyr


5063:tolhs-25methiaz-bala-betapych


5064:tolhs-oxadiaz-gly-betadito


5065:tolhs-me25oxaz-ala-psdap


5066:bhs-ithiadiaz-bala-beta3quin


5067:2py-25oxaz-ala-psdap




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-163-
5068:bim-24thioph-leu-betapy


5069:tolhs-25methiaz-bala-betahmo


5070:bhs-25methiaz-bala-zdapch


5071:bhs-24thiaz-bala-betamethi


5072:2pmhs-24thioph-bala-betamethioph


5073:bim-24thioph-gly-aspaba


5074:ibhs-25methihz-gly-betatrif


5075:bhs-24thioph-gly-beta3quin


5076:ibhs-oxadiaz-gly-betatrif


105077:2py-triaz-bala-betapy


5078:phhs-24thioph-bala-betameph


5079:bim-25oxaz-gly-psdap


5080:tolhs-nme35pyr-bala-betabthioph


5081:tolhs-25thiaz-gly-betahmph


155082:bhs-42nmeim-ala-betapy


5083:tolhs-25oxaz-bala-beta34meoph


5084:ibhs-24thiaz-gly-betameph


5085:bim-me24thioph-bala-betadcph


5086:2py-26py-gly-betabiph


205087:ibhs-25thiaz-bala-betaheph


5088:bhs-25thiaz-nmgly-betadhbfu


5089:tolhs-oxadiaz-gly-betameph


5090:bhs-nme35pyr-nmgly-beta34meoph


5091:dhpyrr-24thiaz-gly-betapy


255092:tolhs-25oxaz-bala-betathioph


5093:bhs-24thiaz-bala-betaipro


5094:bhs-25oxaz-ala-betamesu


5095:ibhs-24thioph-gly-betathiobe


5096:nmhs-25methiaz-gly-betadcph


305097:phhs-24thiaz-gly-aspibua


5098:bhs-oxadiaz-gly-betapytb


5099:bim-24thiaz-bala-psdap


5100:ibhs-nme35pyr-bala-betabenfu


5101:ibhs-24thiaz-bala-betaomebendi


355102:ibhs-25thiaz-bala-betabnaphth


5103:2py-25oxaz-leu-betapy


5104:phhs-ithiadiaz-gly-aspbzla




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-164
5105:ibhs-25thiaz-bala-betabdimo


5106:2py-me24thioph-gly-betadcph


5107:tolhs-oxadiaz-bala-betaipro


5108:ibhs-24thiaz-bala-betahmph


5109:bhs-25thiaz-gly-aspaba


5110:2py-35thioph-ala-betapy


5111:bhs-24thioph-gly-zdaptb


5112:phhs-nme35pyr-gly-betatrif


5113:tolhs-25oxaz-gly-betaphethioa


5114:thazep-24thiaz-gly-betadcph


5115:tolhs-ithiadiaz-gly-betadcphch


5116:phhs-25oxaz-bala-betafbph


5117:tolhs-25methiaz-gly-betamethioph


5118:impy-24thiaz-gly-betambiph


5119:phhs-oxadiaz-bala-betafu3


5120:tolhs-me24thiaz-leu-zdap


5121:ibhs-ithiadiaz-bala-betabediox


5122:bhs-oxadiaz-gly-betahc


5123:tolhs-24thiaz-gly-betahmph


5124:bhs-oxadiaz-bala-zdap


5125:bhs-oxadiaz-bala-betahbcph


5126:bim-24thiaz-gly-psdap


5127:bhs-24thiaz-ala-betampy


5128:2pmhs-25oxaz-gly-beta35dbph


5129:bhs-26py-gly-betainyl


5130:bhs-nme35pyr-bala-betapym


5131:2py-26py-met-zdap


5132:ibhs-25oxaz-bala-betacthioph


5133:impy-24thioph-gly-betabthioph


5134:tolhs-oxadiaz-gly-betahdcph


5135:bhs-24thiaz-gly-betapych


5136:bhs-oxadiaz-ala-psdap


5137:phhs-24thiaz-gly-betadcphee


5138:phhs-oxadiaz-gly-betaibph


5139:ibhs-25oxaz-bala-betadhbfu


5140:ibhs-25thiaz-bala-betathiobe


5141:bhs-nme35pyr-ala-betadcph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-165-
5142:bhs-25oxaz-bala-betampy


5143:2py-26py-ala-betainyl


5144:tolhs-25oxaz-bala-beta13bendi


5145:tolhs-nme35pyr-bala-betahmo


5146:bhs-nme35pyr-gly-betadbph


5147:bim-me25thioph-bala-psdap


5148:bhs-25oxaz-ala-beta34dcph


5149:ibhs-nme35pyr-gly-zdaptb


5150:tolhs-25methiaz-bala-betamethi


5151:bhs-nme35pyr-gly-beta13bendi


5152:2py-me25thioph-leu-psdap


5153:ibhs-24thioph-bala-betatbuph


5154:sabhs-24thiaz-gly-psdap


5155:bhs-25thiaz-bala-betahmph


5156:bim-triaz-gly-betapy


5157:phhs-24thioph-bala-betamethioph


5158:phhs-nme35pyr-bala-psdaptb


5159:dhim-24py-gly-betameph


5160:cima-25thiaz-bala-psdap


5161:bhs-24thiaz-gly-betampy


5162:tolhs-25methiaz-bala-beta23meoph


5163:2py-ithiadiaz-ala-betapy


5164:impy-25methiaz-gly-betabthioph


5165:ibhs-24thioph-bala-betaoxope


5166:tolhs-me25thiaz-gly-beta34meoph


5167:ibhs-nme35pyr-gly-betamethi


5168:ibhs-nme35pyr-gly-betabpy


5169:tolhs-25methiaz-bala-betaph


5170:tolhs-24thioph-gly-betapyr


5171:ibhs-25oxaz-bala-betahph


5172:bim-24thiaz-bala-betafphe


5173:tolhs-me24thioph-gly-betadcph


5174:bhs-ithiadiaz-gly-psdapch


5175:2py-24thiaz-bala-betapy


5176:tolhs-nme35pyr-bala-betaipro


5177:bhs-24thioph-nmgly-beta23meoph


5178:bim-52thiaz-gly-betadcph




CA 02371604 2001-10-24
W000/66618 PCTIEP00103469
-166-
5179: gua-24oxaz-gly-betathioph


5180: bhs-triaz-gly-betadcph


5181: bim-42nmeim-bala-betaipr


5182: tolhs-25thiaz-gly-betapym


5183: phhs-25thiaz-bala-betadcphch


5184: phhs-ithiadiaz-gly-betafu2


5185: phhs-ithiadiaz-bala-betampy


5186: phhs-ithiadiaz-gly-betadcphtb


5187: dhim-26py-ala-betapy


5188:phhs-oxadiaz-gly-betamesu


5189: ibhs-25methiaz-bala-psdapee


5190: phhs-me24thioph-gly-zdap


5191: ibhs-25oxaz-gly-betadmph


5192: bhs-25methiaz-gly-betadcphee


5193:bim-oxadiaz-ala-psdap


5194: phhs-ithiadiaz-gly-betaamibe


5195: 2py-rne25oxaz-gly-betaph


5196: phhs-25oxaz-bala-aspaba


5197: bim-me25oxaz-leu-zdap


5198:2py-25thiaz-bala-betafluo


5199: ibhs-24thioph-gly-betafphe


5200: bim-25thiaz-bala-betapy


5201: bhs-24thioph-bala-betatos


5202: gua-25thiaz-gly-betabdimo


5203:2py-42oxaz-ala-betadcph


5204: bhs-ithiadiaz-gly-betamethioph


5205: tolhs-me25thioph-leu-betapy


5206: bhs-25thiaz-ala-psdap


5207: ibhs-25thiaz-bala-betaoxope


5208:bhs-25oxaz-bala-betahmph


5209: bhs-25thiaz-gly-betabthioph


5210: tolhs-24thioph-gly-betabenfu


5211: phhs-me25thioph-leu-betaph


5212: tolhs-25thiaz-gly-ibsdap


5213:phhs-24thioph-gly-betahni


5214: bhs-24thioph-gfy-betaipr


5215: tolhs-me25oxaz-ala-betapy




CA 02371604 2001-10-24
W000166618 ~ PCTIEP00103469
-167-
5216:phhs-me24thioph-bala-zdap


5217:bhs-25oxaz-bala-betathioph


5218:ibhs-ithiadiaz-gly-zdaptb


5219:ibhs-24thioph-bala-betahmo


5220:tolhs-25methiaz-gly-betabthioph


5221:tolhs-nme35pyr-gly-betaibph


5222:tolhs-me24thioph-gly-zdap


5223:phhs-24thiaz-gly-ibsdap


5224:tolhs-25thiaz-gly-betahbcph


5225:ibhs-oxadiaz-bala-betafph


5226:bhs-oxadiaz-nmgly-betahmph


5227:impy-42nmeim-bala-betameph


5228:gua-25thiaz-gly-betadcph


5229:phhs-oxadiaz-gly-betapym


5230:bhs-24thioph-gly-betabmph


5231:phhs-24thioph-gly-aspibua


5232:bhs-25oxaz-ala-betahph


5233:ibhs-24thiaz-gly-asppha


5234:2py-42oxaz-gly-zdap


5235:phhs-me24thiaz-gly-beta34meoph


5236:bhs-nme35pyr-bala-betamethi


5237:bhs-25oxaz-bala-betaheph


5238:dhim-25thiaz-ala-betameph


5239:bhs-ithiadiaz-gly-beta35dbph


5240:bim-oxadiaz-ala-betapy


5241:ibhs-nme35pyr-bala-betafu3


5242:phhs-ithiadiaz-gly-betabpy


5243:tolhs-ithiadiaz-gly-betah35dc


5244:2py-me25thiaz-ala-psdap


5245:bim-24im-ala-zdap


5246:bim-me25oxaz-gly-beta34meoph


5247:bhs-oxadiaz-bala-betapbiph


5248:bhs-24thioph-gly-beta4bph


5249:ibhs-25methiaz-bala-betaibph


5250:ibhs-24thiaz-gly-betatbuph


5251:bhs-oxadiaz-nmgly-betaanaphth


5252:phhs-25thiaz-gly-betamethi




CA 02371604 2001-10-24
W000166618 PGTIEP00103469
-168-
5253:ibhs-ithiadiaz-gly-betadcphtb


5254:tolhs-24thioph-bala-betaet


5255:bhs-25methiaz-bala-beta34meoph


5256:ibhs-25thiaz-bala-suabu


5257:2py-42nmeim-gly-betapy


5258:tolhs-25thiaz-bala-betahmph


5259:bhs-25thiaz-gly-betahni


5260:2pmhs-42nmeim-bala-betaphethio


5261:tolhs-25methiaz-gly-betadbph


5262:ibhs-25thiaz-gly-betamethioph


5263:bhs-25thiaz-nmala-betameph


5264:2py-25methiaz-ala-betadcph


5265:bim-35fur-gly-betadcph


5266:bhs-oxadiaz-gly-betabenfu


5267:2py-oxadiaz-gly-betadcph


5268:bhs-25oxaz-bala-betaph


5269:phhs-24thioph-gly-betamethioph


5270:phhs-oxadiaz-bala-betafu2


5271:bhs-25methiaz-gly-betaoxaz


5272:tolhs-25thiaz-bala-betacbph


5273:tolhs-25oxaz-gly-betah35dc


5274:ibhs-24thiaz-gly-aspaba


5275:bim-25oxaz-bala-aspbzla


5276:tolhs-oxadiaz-bala-betahmofu


5277:bhs-25oxaz-bala-csdap


5278:tolhs-oxadiaz-gly-zdaptb


5279:phhs-25thiaz-bala-beta34dcph


5280:phhs-24thioph-bala-betambiph


5281:tolhs-24thiaz-gly-betabthioph


5282:bhs-24thiaz-bala-betaomebendi


5283:phhs-25thiaz-bala-beta35dbph


5284:ibhs-25methiaz-bala-aspbzla


5285:bhs-24thioph-ala-beta23meoph


5286:bhs-nme35pyr-bala-csdap


5287:phhs-24thiaz-bala-betafu3


5288:ibhs-25methiaz-gly-betaimid


5289:ibhs-24thiaz-gly-betafph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-169
5290:impy-25oxaz-bala-betabenfu


5291;bhs-25thiaz-bala-suabu


5292:phhs-24thioph-gly-betabdimo


5293:tolhs-me24thioph-bala-psdap


5294:ibhs-24thioph-gly-betabenfu


5295:bim-35fur-ala-betapy


5296:bhs-25oxaz-bala-suabu


5297:bhs-25thiaz-bala-betamethi


5298:bhs-oxadiaz-bala-betabpy


5299:gua-24thiaz-gly-betaamibe


5300:bhs-25methiaz-bala-betathioph


5301:phhs-me25thiaz-gly-betadcph


5302:bhs-24thiaz-bala-ibsdap


5303:ibhs-25thiaz-bala-aspaba


5304:tolhs-ithiadiaz-bala-betaheph


5305:bhs-25oxaz-nmgly-betahph


5306:tolhs-24thioph-gly-betaol


5307:bhs-25methiaz-bala-betapych


5308:2py-42nmeim-bala-betaomebendi


5309:bhs-25methiaz-bala-betabthioph


5310:bhs-25thiaz-bala-betaimid


5311:tolhs-24thiaz-gly-betahb


5312:ibhs-ithiadiaz-bala-betacph


5313:ibhs-25oxaz-gly-asppha


5314:phhs-25thiaz-gly-betahdbph


5315;tolhs-ithiadiaz-g1y-betacthioph


5316:bhs-ithiadiaz-ala-beta13bendi


5317:tolhs-25oxaz-gly-betabph


5318:ibhs-25thiaz-bala-betaomebendi


5319:bhs-ithiadiaz-gly-ibsdap


5320:ibhs-24thiaz-gly-betapyee


5321:tolhs-24thioph-bala-betathiobe


5322:bhs-ithiadiaz-gly-betapyee


5323:ibhs-24thioph-gly-betadito


5324:bim-me24oxaz-leu-beta34meoph


5325:tolhs-24thiaz-bala-busu2be


5326:bhs-25thiaz-gly-betaoxaz




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-170-
5327: ibhs-nme35pyr-gly-aspaba
5328: ibhs-nme35pyr-bala-betatrif
5329: bhs-25oxaz-bala-betafph
5330: tolhs-25oxaz-bala-betacbph
5331; 2py-oxadiaz-ala-betadcph
5332: phhs-24thiaz-bala-busu2be
5333: tolhs-25methiaz-gly-betainyl
5334: phhs-nme35pyr-bala-betafu3
5335: bhs-24thiaz-gly-betaphethioa
5336: ibhs-25oxaz-gly-aspibua
5337: tolhs-24thiaz-gly-betaphethioa
5338: 2py-25methiaz-gly-beta35dbph
5339: ibhs-nme35pyr-gly-betahb
5340: 2py-25thiaz-bala-betadcph
5341; 2py-me24thioph-leu-zdap
5342: phhs-nme35pyr-gly-betaipr
5343: bhs-25oxaz-nmgiy-betacph
5344: tolhs-oxadiaz-bala-beta4bph
5345: bhs-24thioph-ala-betadcph
5346. phhs-25thiaz-gly-beta13bendi
5347: tolhs-oxadiaz-gly-suabu
5348: bhs-25oxaz-bala-betapyee
5349: tolhs-25thiaz-bala-aspbzla
5350: tolhs-24thiaz-gly-betahcbph
5351: ibhs-oxadiaz-bala-betatrif
5352: bhs-24thiaz-bala-zdap
5353: ibhs-ithiadiaz-bala-betapyee
5354: 2py-42nmeim-leu-betadcph
5355: bim-42pym-gly-betameph
5356: tolhs-25oxaz-gly-betafph
5357: phhs-25oxaz-bala-betahmo
5358: bhs-25thioph-ala-betainyl
5359: phhs-25methiaz-gly-betaftrif
5360: bim-25oxaz-bala-betapy
5361: ibhs-nme35pyr-gly-betaol
5362: 2py-25methiaz-gly-betatbuph
5363: bhs-25thiaz-bala-betadmoph


CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-171-
5364: tolhs-24thioph-bala-csdap


5365: ibhs-oxadiaz-gly-beta13bendi


5366: tolhs-nme35pyr-gly-betampy


5367: bhs-25oxaz-bala-betaoxaz


5368: bhs-nme35pyr-nmgly-betafphe


5369: tolhs-nme35pyr-bala-betadcph


5370: tolhs-nme35pyr-bala-betadmoph


5371: 2py-25thiaz-gly-betapy


5372: dhim-42pym-ala-betameph


5373:bhs-24thiaz-bala-betapy


5374: phhs-oxadiaz-bala-betaimid


5375: ibhs-ithiadiaz-gly-betahmph


5376: tolhs-24thioph-bala-zdapch


5377: 2py-24oxaz-ala-psdap


5378:ibhs-ithiadiaz-gly-betambiph


5379: bim-nme35pyr-bala-psdap


5380: bim-25fur-leu-betadcph


5381: bhs-oxadiaz-bala-psdap


5382: phhs-25methiaz-bala-betaipr


5383:bhs-me25thiaz-ala-zdap


5384: ibhs-ithiadiaz-bala-betameph


5385: bhs-25oxaz-gly-beta13bendi


5386: tolhs-nme35pyr-bala-betabdimo


5387: ibhs-oxadiaz-bala-betahc


5388:bhs-25oxaz-bala-beta34dcph


5389: ibhs-25thiaz-bala-betadhbfu


5390: bhs-25methiaz-gly-betatrif


5391: ibhs-24thiaz-bala-betafu2


5392: phhs-ithiadiaz-gly-betabediox


5393:bhs-me25thioph-gly-betapy


5394: bhs-me25oxaz-ala-betadcph


5395: bhs-24thiaz-gly-betaphethio


5396: tolhs-24thiaz-bala-betadtrif


5397: bhs-ithiadiaz-nmgly-betaanaphth


5398:phhs-24thiaz-bala-betadcphtb


5399: bhs-ithiadiaz-ala-betacph


5400: thpym-24thioph-bala-psdap




CA 02371604 2001-10-24
W000/66618 PCTIEP00/03469
-172-
5401:bhs-25oxaz-ala-betathioph


5402:bim-25methiaz-nmala-betadcph


5403:tolhs-25methiaz-gly-betahc


5404:bhs-25py-gly-betapy


5405:bim-me24thiaz-leu-zdap


5406:ibhs-oxadiaz-bala-betapyee


5407:phhs-me25oxaz-bala-betaph


5408:phhs-ithiadiaz-bala-betahmofu


5409:ibhs-25oxaz-bala-betafbph


105410:phhs-ithiadiaz-gly-betabmph


5411:phhs-25thiaz-gly-betabthioph


5412:ibhs-25methiaz-gly-aspibua


5413:tolhs-25thiaz-gly-psdapee


5414:bim-25thioph-ala-psdap


155415:bhs-ithiadiaz-nmgly-beta23meoph


5416:bhs-24thiaz-gly-betahb


5417:tolhs-25thiaz-gly-betamethi


5418:tolhs-oxadiaz-bala-betapych


5419:bim-25methiaz-ala-psdap


205420:bhs-me24oxaz-leu-betapy


5421:tolhs-25methiaz-gly-beta4bph


5422:dhim-26py-gly-betapy


5423:ibhs-oxadiaz-gly-asppha


5424:2py-24thiaz-leu-betadcph


255425:tolhs-oxadiaz-bala-betabmph


5426:bhs-oxadiaz-bala-betafu2


5427:bhs-25methiaz-bala-betaipro


5428:tolhs-25methiaz-gly-betapych


5429:phhs-25thiaz-bala-beta4bph


305430:bim-thiadiaz-leu-betadcph


5431:tolhs-24thiaz-gly-betabmph


5432:gua-42pym-gly-betaheph


5433:phhs-ithiadiaz-bala-betaipr


5434:2pmhs-25thiaz-bala-betapyr


355435:tolhs-me24thioph-leu-betadcph


543fi:bhs-oxadiaz-gly-betamethi


5437:phhs-24thiaz-bala-betathiome




CA 02371604 2001-10-24
WO00/66618 PCTIEP00103469
-173-
5438:ibhs-nme35pyr-bala-betamethioph


5439:tolhs-me24thiaz-ala-psdap


5440:tolhs-24thioph-gly-betadito


5441:bhs-24thiaz-bala-betahdcph


5442:phhs-24thiaz-gly-betathiobe


5443:bim-42pym-ala-betameph


5444:phhs-24thiaz-gly-zdaptb


5445:bhs-24thiaz-gly-csdap


5446:bhs-oxadiaz-bala-betadtrif


5447:2py-42oxaz-a(a-psdap


5448:phhs-oxadiaz-bala-beta4bph


5449:bhs-oxadiaz-gly-betahdbph


5450:gua-26py-gly-beta4bph


5451:bhs-26pyrazi-ala-betapy


5452:tolhs-24thiaz-gly-psdaptb


5453:bhs-42nmeim-gly-betaheph


5454:ibhs-ithiadiaz-bala-betatbuph


5455:ibhs-24thioph-bala-betatrif


5456:phhs-25methiaz-gly-betaph


5457:bim-me24thioph-bala-zdap


5458:ibhs-oxadiaz-bala-betabthioph


5459:bhs-me24oxaz-leu-psdap


5460:tolhs-24thiaz-gly-betapych


5461:phhs-25thiaz-gly-betaol


5462:bhs-me24im-gly-zdap


5463:bim-25oxaz-gly-betathiome


5464:impy-25oxaz-bala-betaamibe


5465:tolhs-25methiaz-bala-asppha


5466:ibhs-24thioph-bala-betahdcph


5467:ibhs-25methiaz-bala-busu2be


5468:bhs-24thiaz-bala-betabmph


5469:bhs-me25thioph-gly-psdap


5470:ibhs-24thiaz-bala-betafluo


5471:dhim-24thiaz-ala-betapy


5472:bim-25thioph-leu-betadcph


5473:thpym-24thiaz-bala-psdap


5474:bhs-25oxaz-bala-betameph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-174-
5475: bhs-24thiaz-gly-betaoxaz


5476: bim-24thiaz-ala-psdap


5477: phhs-24thiaz-bala-betaoxaz


5478: bhs-ithiadiaz-bala-betahb


5479:bhs-ithiadiaz-bala-zdapee


5480; bhs-25oxaz-nmgly-betaoxaz


5481: bhs-25thiaz-nmgly-betadito


5482: bhs-nme35pyr-gly-psdapch


5483: ibhs-nme35pyr-gly-betadbph


5484:phhs-me24oxaz-leu-zdap


5485: bhs-oxadiaz-bala-betaoxaz


5486: bhs-oxadiaz-gly-betadito


5487: gua-42pym-gly-betathiobe


5488: bim-42nmeim-ala-betadcph


5489:bhs-42nmeim-gly-betabnaphth


5490: phhs-ithiadiaz-bala-betapytb


5491: 2py-ithiadiaz-bala-aspbzla


5492: bhs-24thioph-gly-betafbph


5493: bhs-oxadiaz-bala-betaanaphth


5494:bhs-me24oxaz-bala-betaph


5495: phhs-25thiaz-bala-betacthioph


5496: tolhs-25methiaz-bala-betapyee


5497: bhs-25methiaz-gly-beta35dbph


5498: phhs-me24oxaz-gly-betapy


5499:ibhs-25methiaz-bala-betaph


5500: 2py-24oxaz-bala-betapy


5501: ibhs-ithiadiaz-gly-aspibua


5502: phhs-25thiaz-gly-betadcphee


5503: bhs-24pym-gly-zdap


5504:tolhs-24thiaz-gly-betathioph


5505: tolhs-ithiadiaz-bala-betadcphch


5506: 2py-ithiadiaz-leu-betadcph


5507: phhs-24thiaz-bala-betapyee


5508: phhs-ithiadiaz-bala-betadcph


5509:bhs-25oxaz-bafa-betamethioph


5510: 2py-53pyrazo-leu-betapy


5511: ibhs-25oxaz-gly-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-175
5512:ibhs-oxadiaz-gly-csdap


5513:bim-25methiaz-ala-betadcph


5514:phhs-25methiaz-bala-betamethioph


5515:bhs-oxadiaz-bala-psdaptb


5516:2py-me25thiaz-gly-betapy


5517:tolhs-25thiaz-gly-betacph


5518:impy-42nmeim-gly-betapyr


5519:bim-25methiaz-bala-betafphe


5520:phhs-25oxaz-gly-betapytb


5521:ibhs-25oxaz-gly-betapbiph


5522:2py-me25oxaz-bala-psdap


5523:bhs-ithiadiaz-bala-zdaptb


5524:2py-25methiaz-bafa-betafluo


5525:bhs-25thiaz-gly-betacthioph


5526:bhs-nme35pyr-bala-beta35dbph


5527:bhs-25oxaz-bala-betadcph


5528:tolhs-25thiaz-gly-betahdbph


5529:phhs-25thiaz-bala-betafph


5530:bhs-25thiaz-bala-betahdcph


5531:bhs-ithiadiaz-gly-betafu3


5532:bhs-25thiaz-bala-betapym


5533:bhs-ithiadiaz-ala-beta23meoph


5534:ibhs-nme35pyr-bala-betapych


5535:bhs-me25oxaz-bala-betapy


5536:2py-nme35pyr-bala-asppha


5537:2py-35thioph-bala-betapy


5538:phhs-nme35pyr-bala-betadcphee


5539:tolhs-25oxaz-bala-betabpy


5540:bhs-24thioph-bala-betacthioph


5541:bhs-24thioph-ala-betabpy


5542:bim-24im-leu-betadcph


5543:bhs-oxadiaz-gly-betamesu


5544:bhs-thiadiaz-gly-betadcph


5545:tolhs-25thiaz-bala-betameph


5546:bhs-thiadiaz-ala-psdap


5547:bhs-24thioph-bala-betadcphch


5548:bhs-ithiadiaz-gly-betabenfu




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-176
5549:ibhs-nme35pyr-bala-betadcphee


5550:bhs-me25oxaz-leu-betaph


5551:bhs-me24thiaz-leu-betadcph


5552:tolhs-25thiaz-gly-betatbuph


5553:gua-25thioph-gly-betacbph


5554:phhs-25methiaz-gly-betahph


5555:2py-me25thiaz-bala-psdap


5556:bhs-25methiaz-nmgly-betabpy


5557:bhs-oxadiaz-nmgly-betameph


5558:tolhs-24thiaz-gly-betacthioph


5559:dimethpyin-24thioph-gly-betameph


5560:ibhs-25oxaz-bala-betameph


5561:bhs-24thioph-bala-aspbzla


5562:ibhs-24thioph-bala-betabediox


5563:tolhs-25oxaz-bala-betaphethioa


5564:ibhs-24thiaz-gly-betabpy


5565:tolhs-25oxaz-bala-betacthioph


5566:tolhs-24thioph-bala-betapbiph


5567:ibhs-oxadiaz-bala-betahbcph


5568:phhs-oxadiaz-bala-betatrif


5569:bhs-25oxaz-bala-betabmph


5570:ibhs-oxadiaz-gly-betameph


5571:phhs-ithiadiaz-bala-betathiome


5572:tolhs-ithiadiaz-bala-betacthioph


5573:phhs-24thiaz-bala-betaftrif


5574:ibhs-ithiadiaz-bala-betamethi


5575:ibhs-ithiadiaz-gly-betabenfu


5576:ibhs-24thioph-gly-betahdcph


5577:phhs-me25thioph-bala-betaph


5578:2py-oxadiaz-gly-aspbzla


5579:bhs-24thiaz-nmgly-betameph


5580:tolhs-oxadiaz-bala-betadtrif


5581:bhs-oxadiaz-bala-beta3quin


5582:hs-25thioph-gly-betapy


5583:2py-53pyrazo-gly-betapy


5584:bhs-me25thiaz-leu-beta34meoph


5585:bgua-25thiaz-gly-betapy




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-177-
5586:tolhs-nme35pyr-gly-betahni


5587:tolhs-25thiaz-gly-betafphe


5588:bhs-ithiadiaz-bala-csdap


5589:dhim-24thiaz-gly-betadtrif


5590:bim-24thiaz-bala-aspaba


5591:phhs-25thiaz-bala-betaheph


5592:bhs-24thiaz-gly-beta13bendi


5593:ibhs-25oxaz-bala-betathioph


5594:phhs-25methiaz-gly-betafu3


5595:tolhs-ithiadiaz-gly-betamethioph


5596:2py-42nmeim-gly-betatos


5597:ibhs-25oxaz-bala-betapyr


5598:ibhs-nme35pyr-bala-betamethi


5599:bhs-24thioph-bala-betaheph


5600:ibhs-24thiaz-bala-betadcphtb


5601:phhs-25thiaz-gly-betaheph


5602:ibhs-nme35pyr-bala-betaphethio


5603:ibhs-25methiaz-gly-betathio3


5604:tolhs-nme35pyr-gly-betaol


5605:tolhs-24thioph-gly-suabu


5606:bhs-25oxaz-gly-beta35dbph


5607:tolhs-24thiaz-giy-aspbzla


5608:bhs-24thioph-nmgly-betameph


5609:tolhs-ithiadiaz-bala-betahni


5610:bhs-25oxaz-gly-busu2be


5611:phhs-me25thioph-gly-beta34meoph


5612:bhs-24thiaz-gly-betadcphtb


5613:bim-26py-gly-betapy


5614:2py-me24thiaz-ala-betaph


5615:2py-me24oxaz-bala-betadcph


5616:bhs-25methiaz-gly-betahni


5617:bhs-25methiaz-gly-betabph


5618:bhs-24thiaz-bala-betafphe


5619:tolhs-ithiadiaz-bala-betafbph


5620:ibhs-oxadiaz-gly-betahc


5621:phhs-nme35pyr-baia-betabmph


5622:bhs-25methiaz-bala-betaimid




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-178-
5623: tolhs-oxadiaz-bala-betadbph


5624: bhs-25methiaz-gly-beta34dcph


5625: bhs-ithiadiaz-nmgly-betainyl


5626: bhs-25methiaz-gly-zdap


5627: gua-25thioph-gly-beta13bendi


5628: phhs-24thiaz-bala-betaibph


5629: bhs-24thioph-bala-betamethi


5630: bim-me24oxaz-ala-betapy


5631: phhs-24thioph-bala-betahmo


5632:ibhs-24thioph-gly-betahmo


5633: tolhs-oxadiaz-bala-betafph


5634: ibhs-25oxaz-gly-betafluo


5635: phhs-25thiaz-gly-betaipro


5636: 2py-thiadiaz-ala-zdap


5637:tolhs-ithiadiaz-gly-betadcphtb


5638: ibhs-25thiaz-bala-betahb


5639: phhs-me24thioph-gly-betaph


5640: phhs-oxadiaz-gly-betapy


5641: tolhs-nme35pyr-gly-betathio3


5642:bhs-25methiaz-gly-betafphe


5643: bhs-nme35pyr-bala-betatrif


5644: phhs-nme35pyr-bala-betaheph


5645: bim-25thiaz-bala-asppha


5646: 2py-25thiaz-bala-beta34dcph


5647:bhs-24thiaz-gly-suabu


5648: ibhs-24thioph-bala-betafbph


5649: tolhs-25thiaz-bala-zdapee


5650: tolhs-ithiadiaz-bala-ibsdap


5651: bhs-25methiaz-gly-betaphethio


5652:ibhs-25oxaz-gly-betapym


5653: phhs-25oxaz-bala-betahb


5654: ibhs-ithiadiaz-gly-betainyl


5655: tolhs-me24thiaz-leu-psdap


5656; ibhs-25oxaz-bala-betathio3


5657:2py-53pyrazo-leu-psdap


5658: tolhs-nme35pyr-bala-betacph


5659: ibhs-25thiaz-bala-betafu2




CA 02371604 2001-10-24
WOOOIfi6618 PCTIEP00103469
-179
5660: ibhs-25methiaz-gly-betadcphch


5661: bhs-me24oxaz-ala-zdap


5662: phhs-24thiaz-bala-beta34meoph


5663: tolhs-nme35pyr-bala-betathiobe


5664: phhs-me24thioph-gly-psdap


5665: tolhs-25oxaz-gly-betabpy


5666: 2py-25oxaz-gly-asppha


5667: ibhs-25methiaz-gly-betacbph


5668: bhs-25methiaz-bala-beta3quin


5669:tolhs-24thioph-gly-beta23meoph


5670: tolhs-nme35pyr-gly-betahcbph


5671: ibhs-25thiaz-bala-betaphethioa


5672: phhs-nme35pyr-gly-betafphe


5673: bhs-ithiadiaz-gly-betabediox


5674:ibhs-24thiaz-gly-betahdbph


5675: tolhs-25methiaz-bala-betathioph


5676: tolhs-nme35pyr-bala-betamethi


5677: tolhs-25thiaz-gly-betabenfu


5678: gua-24thiaz-gly-betabdimo


5679:phhs-24thiaz-bala-psdapee


5680: phhs-oxadiaz-gly-psdapch


5681: phhs-25oxaz-gly-betahdcph


5682: ibhs-24thioph-bala-betapym


5683: tolhs-25thiaz-gly-betahb


5684:bhs-42nmeim-gly-betaet


5685: bim-me25thioph-ala-betapy


5686: bim-25thiaz-leu-betadcph


5687: bhs-25thiaz-bala-betapyee


5688: ibhs-25methiaz-bala-betahmo


5689:phhs-25oxaz-gly-betacbph


5690: dhim-42pym-ala-zdap


5691: bhs-oxadiaz-gly-betathioph


5692: tolhs-25oxaz-gly-betahmo


5693: phhs-24thiaz-gly-betaipr


5694:tolhs-me24oxaz-leu-betapy


5695: phhs-oxadiaz-gly-betapytb


5696: ibhs-25methiaz-gly-beta35dbph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-180
5697:bhs-ithiadiaz-gly-betadhbfu


5698:phhs-25thiaz-gly-busu2be


5699:bhs-nme35pyr-bala-betambiph


5700:bim-24thioph-gly-betapy


5701:ibhs-nme35pyr-gly-betadcphtb


5702:bim-25methiaz-gly-psdap


5703:phhs-nme35pyr-bala-betaipr


5704:gua-25thiaz-gly-betainyl


5705:bhs-25oxaz-bala-betafluo


105706:gua-25thioph-gly-betahmph


5707:tolhs-24thioph-gly-betainyl


5708:bhs-24thioph-bala-betaet


5709:tolhs-25oxaz-bala-betafu3


5710:2py-24thiaz-bala-beta34dcph


155711:gua-42pym-gly-betaph


5712:tolhs-ithiadiaz-gly-betahni


5713:2py-42nmeim-leu-psdap


5714:2py-24thiaz-hphe-psdap


5715:phhs-nme35pyr-gly-zdapee


205716:bhs-26py-ala-betapy


5717:ibhs-25methiaz-gly-betabph


5718:bhs-25methiaz-bala-betaphethioa


5719:tolhs-me25thiaz-aia-zdap


5720:bhs-24thioph-bala-beta3quin


255721:dhim-25thioph-ala-betainyl


5722:phhs-oxadiaz-gly-betahph


5723:tolhs-25oxaz-gly-betatbuph


5724:bhs-oxadiaz-gly-betaphethio


5725:bim-me24oxaz-ala-betaph


305726:tolhs-me25thiaz-leu-beta34meoph


5727:bim-24im-bala-betapy


5728:phhs-ithiadiaz-bala-betahb


5729:tolhs-25methiaz-gly-beta35dbph


5730:ibhs-25thiaz-bala-betadcphee


355731:ibhs-oxadiaz-bala-beta23meoph


5732:gua-24oxaz-gly-betatrif


5733:2py-25thioph-ala-zdap




CA 02371604 2001-10-24
WOOOI6661 g PCTIEPOOI03469
-181
5734: bhs-42oxaz-leu-betadcph


5735: bhs-triaz-bala-betapy


5736: phhs-25methiaz-bala-beta34dcph


5737: tolhs-ithiadiaz-gly-betabediox


5738: phhs-oxadiaz-bala-beta13bendi


5739: ibhs-25thiaz-bala-betahmo


5740: tolhs-25methiaz-bala-betadhbfu


5741: 2py-me24oxaz-leu-betapy


5742: phhs-ithiadiaz-bala-betafluo


105743: tolhs-24thioph-bala-betathiome


5744: bhs-52thiaz-gly-psdap


5745: tolhs-oxadiaz-gly-betabediox


5746: bhs-ithiadiaz-ala-betabnaphth


5747: phhs-oxadiaz-bala-betaamibe


155748: ibhs-oxadiaz-bala-betadcphch


5749: phhs-24thioph-bala-betafu2


5750: bhs-itbiadiaz-bala-betaoxope


5751: phhs-25oxaz-gly-betaoxaz


5752: ibhs-oxadiaz-bala-betaphethio


205753: bhs-25methiaz-nmgly-beta34meoph


5754: bhs-nme35pyr-gly-betadcph


5755: 2py-24oxaz-gly-betapy


5756: tolhs-25thiaz-bala-psdapch


5757: bhs-25thiaz-bala-betaoxaz


255758: bhs-24oxaz-gly-betameph


5759: bhs-24thioph-ala-betathioph


5760: ibhs-25oxaz-bala-betaipro


5761: phhs-ithiadiaz-bala-betambiph


5762: phhs-24thioph-bala-betaibph


305763: ibhs-ithiadiaz-bala-betadito


5764: tolhs-ithiadiaz-bala-betadcphee


5765: tolhs-oxadiaz-gly-aspbzla


5766: phhs-nme35pyr-gly-betaoxaz


57F7: bhs-42nmeim-gly-beta34dcph


355768: ibhs-oxadiaz-gly-betadito


5769: bhs-nme35pyr-gly-betahbcph


5770: tolhs-24thioph-bala-betamethioph




CA 02371604 2001-10-24
W000166618 PCTlEP00J03469
-182
5771:bhs-25methiaz-gly-beta23meoph


5772:bhs-25methiaz-ala-betahmph


5773:ibhs-25methiaz-bala-betadcphtb


5774:tolhs-24thioph-gly-betadbph


5775:tolhs-ithiadiaz-bala-betaet


5776:ibhs-ithiadiaz-gly-beta3quin


5777:2pm hs-42n meim-met-betapy


5778:ibhs-24thioph-gly-betafph


5779:ibhs-ithiadiaz-gly-betadbph


5780:phhs-25thiaz-bala-beta34meoph


5781:phhs-25oxaz-bala-betamesu


5782:bim-24thiaz-bala-betampy


5783:ibhs-25methiaz-bala-beta34meoph


5784:phhs-oxadiaz-gly-aspibua


5785:2py-me24oxaz-bala-betaph


5786:bhs-24im-leu-betapy


5787:ibhs-25thiaz-gly-betampy


5788:2py-me24thiaz-gly-beta34meoph


5789:ibhs-25methiaz-bala-zdaptb


5790:gua-42pym-gly-betapym


5791:phhs-nme35pyr-bala-psdapee


5792:phhs-oxadiaz-bala-betahph


5793:bhs-35fur-bala-zdap


5794:tolhs-25thiaz-bala-psdaptb


5795:tolhs-25thiaz-gly-betabph


5796:phhs-24thioph-bala-betaftrif


5797:ibhs-oxadiaz-gly-betamethi


5798:phhs-oxadiaz-bala-ibsdap


5799:ibhs-24thioph-bala-aspbzla


5800:bim-me25thioph-ala-betadcph


5801:bhs-24pym-ala-betameph


5802:phhs-me25oxaz-ala-psdap


5803:tolhs-24thioph-bala-betacthioph


5804:2py-24thiaz-gly-betadcph


5805:phhs-25thiaz-bala-betadtrif


5806:phhs-me25thioph-leu-zdap


5807:bhs-42nmeim-bala-zdap




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-183
5808:ibhs-oxadiaz-gly-betadmph


5809:phhs-25oxaz-bala-aspibua


5810:bim-thiadiaz-gly-betapy


5811:tolhs-25methiaz-gly-betadcphch


5812:ibhs-nme35pyr-bala-betahcbph


5813:bhs-25methiaz-bala-suabu


5814:tolhs-25oxaz-bala-betadbph


5815:phhs-ithiadiaz-gly-betaoxaz


5816:bhs-nme35pyr-bala-asppha


5817:tolhs-24thioph-gly-betahb


5818:bim-me25thioph-ala-psdap


5819:gua-24oxaz-gly-zdap


5820:phhs-25thiaz-gly-betabdimo


5821:phhs-25thiaz-gly-aspaba


5822:bhs-53pyrazo-bala-psdap


5823:2py-42nmeim-leu-zdap


5824:phhs-oxadiaz-gly-betadcphee


5825:imhs-25thiaz-gly-zdap


5826:phhs-25thiaz-bala-aspaba


5827:phhs-25methiaz-gly-betadhbfu


5828:bhs-24thiaz-bala-beta34meoph


5829:bhs-24thiaz-gly-betahmph


5830:2py-me25oxaz-bala-betaph


5831:hyd-42nmeim-bala-betadcph


5832:bhs-25thiaz-bala-beta3quin


5833:ibhs-ithiadiaz-bala-betabph


5834:ibhs-24thiaz-gly-betapbiph


5835:2py-25methiaz-bala-betadcph


5836:2py-25oxaz-leu-psdap


5837:tolhs-oxadiaz-gly-psdapch


5838:bhs-24thioph-ala-zdap


5839:bhs-24thioph-bala-betapych


5840:phhs-25thiaz-bala-betadcph


5841:bgua-42pym-gly-betapy


5842:bhs-25methiaz-nmgly-betacph


5843:impy-25oxaz-bala-betafbph


5844:phhs-24thiaz-gly-betadcphch




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-184
5845:phhs-25methiaz-bala-betaimid


5846:ibhs-25methiaz-bala-betahmofu


5847:ibhs-24thiaz-bala-betafbph


5848:ibhs-24thiaz-gly-busu2be


5849:2py-24thioph-hphe-psdap


5850:2py-me24thiaz-leu-beta34meoph


5851:phhs-24thiaz-gly-betaet


5852:phhs-25thiaz-gly-betameph


5853:ibhs-25methiaz-bala-betathiome


5854:tolhs-oxadiaz-bala-betacph


5855:ibhs-nme35pyr-gly-psdaptb


5856:bim-oxadiaz-bala-aspaba


5857:bim-24oxaz-gly-betainyl


5858:bhs-nme35pyr-gly-betaimid


5859:ibhs-25thiaz-bala-betahph


5860:2py-25thiaz-gly-betameph


5861:phhs-24thioph-gly-busu2be


5862:tolhs-25oxaz-gly-betaol


5863:bhs-24thioph-ala-betafphe


5864:bhs-25thiaz-nmgly-betadmoph


5865:ibhs-oxadiaz-bala-aspbzla


5866:bhs-ithiadiaz-bala-betacbph


5867:bim-35fur-ala-psdap


5868:tolhs-25thiaz-gly-betathiome


5869:tolhs-nme35pyr-gly-betahmofu


5870:ibhs-25methiaz-gly-betaibph


5871:tolhs-25thiaz-bala-betapytb


5872:impy-25oxaz-gly-betaphethio


5873:gua-24oxaz-gly-betabthioph


5874:gua-24thiaz-gly-betahcbph


5875:tolhs-nme35pyr-gly-betapym


5876:bim-me24thiaz-leu-betaph


5877:pahs-24thioph-bala-betameph


5878:bim-25thiaz-gly-betahmph


5879:bhs-25thiaz-gly-betabediox


5880:bhs-24thiaz-gly-betathiobe


5881:gua-42pym-nmgly-betapy




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-185
5882:gua-24thiaz-gly-betaipr


5883:tolhs-25thiaz-bala-psdap


5884:gua-24thiaz-gly-busu2be


5885:bhs-24thiaz-ala-betaoxaz


5886:tolhs-oxadiaz-bala-betabpy


5887:bhs-24thiaz-gly-betapbiph


5888:bhs-me24oxaz-gly-beta34meoph


5889:bhs-24thioph-bala-betaoxaz


5890:tolhs-ithiadiaz-gly-betahmph


5891:phhs-25methiaz-bala-busu2be


5892:bhs-24im-leu-zdap


5893:bhs-24thioph-bala-betabpy


5894:bhs-25methiaz-bala-betabpy


5895:ihhs-25oxaz-bala-betadcphtb


5896:bhs-25methiaz-gly-ibsdap


5897:phhs-24thiaz-bala-betathioph


5898:phhs-25methiaz-bala-zdap


5899:ibhs-25oxaz-gly-betaamibe


5900:imhs-24thioph-gly-zdap


5901:phhs-oxadiaz-gly-betafluo


5902:2py-26py-ala-betadcph


5903:2py-me25thioph-leu-betaph


5904:tolhs-25methiaz-gly-betaoxope


5905:phhs-ithiadiaz-bala-betaol


5906:tolhs-24thiaz-gly-betadtrif


5907:bhs-25methiaz-gly-psdapee


5908:bhs-ithiadiaz-gly-beta23meoph


5909:bhs-me24thiaz-gly-zdap


5910:2pmhs-25methiaz-gly-betafph


5911:bhs-25oxaz-bala-betadtrif


5912:bhs-25methiaz-bala-betatos


5913:bim-24thioph-bala-psdap


5914:tolhs-nme35pyr-bala-betafbph


5915:tolhs-24thiaz-bala-aspaba


5916:2py-triaz-gly-betadcph


5917:ibhs-24thiaz-gly-betahph


5918:tolhs-nme35pyr-gly-beta4bph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-186
5919:tolhs-ithiadiaz-bala-beta4bph


5920:phhs-25oxaz-gly-betadcph


5921:phhs-25methiaz-bala-betadmoph


5922:phhs-oxadiaz-gly-csdap


5923:tolhs-oxadiaz-bala-betadmph


5924:impy-42nmeim-bala-betahbcph


5925:tolhs-24thioph-gly-csdap


5926:ibhs-24thioph-bala-betabmph


5927:bhs-ithiadiaz-bala-betapyr


105928:tolhs-25thiaz-gly-betathiobe


5929:bhs-nme35pyr-bala-betabpy


5930:phhs-oxadiaz-gly-betadmph


5931:tolhs-24thiaz-bala-betadcphch


5932:dhim-25thioph-ala-betameph


155933:bhs-24thioph-bala-betaomebendi


5934:phhs-25oxaz-bala-betadmph


5935:bim-me24oxaz-leu-betapy


5936:bhs-oxadiaz-gly-betainyl


5937:tolhs-oxadiaz-gly-betaanaphth


205938:tolhs-24thioph-bala-betabph


5939:phhs-25thiaz-bala-betambiph


5940:bhs-me25oxaz-bala-zdap


5941:2pmhs-25oxaz-bala-betaet


5942:phhs-24thioph-gly-betahph


255943:bhs-oxadiaz-gly-betadtrif


5944:2py-oxadiaz-leu-betapy


5945:bhs-nme35pyr-bala-betaheph


5946:bim-25fur-gly-betapy


5947:bhs-25methiaz-gly-betaoxope


305948:tolhs-25oxaz-gly-betatrif


5949:dhthi-25oxaz-gly-zdap


5950:bhs-oxadiaz-nmgly-beta23meoph


5951:tolhs-25oxaz-gly-betaibph


5952:phhs-24thiaz-bala-betaanaphth


355953:bim-24thiaz-bala-betacph


5954:2py-42nmeim-bala-betadcph


5955:ibhs-25thiaz-gly-psdapee




CA 02371604 2001-10-24
WO00I66618 PCTlEP00103469
-187
5956:bhs-ithiadiaz-nmgly-beta3quin


5957:tolhs-24thioph-gly-betaheph


5958:bhs-ithiadiaz-ala-beta34meoph


5959:phhs-25oxaz-bala-csdap


5960:tolhs-ithiadiaz-gly-betabenfu


5961:ibhs-ithiadiaz-gly-betafu3


5962:bhs-26py-ala-betainyl


5963:bim-me25thioph-ala-zdap


5964:phhs-nme35pyr-bala-aspibua


5965:phhs-ithiadiaz-bala-zdap


5966:ibhs-oxadiaz-bala-betadcphee


5967:tolhs-oxadiaz-gly-betathioph


5968:impy-25methiaz-bala-busu2be


5969:bhs-ithiadiaz-bala-suabu


5970:bhs-nme35pyr-nmgly-betacthioph


5971:bhs-35fur-bala-psdap


5972:bhs-24thiaz-bala-betaftrif


5973:bhs-25oxaz-gly-betafbph


5974:tolhs-25thiaz-gly-betaibph


5975:2py-me24thiaz-gly-betadcph


5976:2py-me24oxaz-bala-psdap


5977:bim-ithiadiaz-ala-betadcph


5978:2py-25thiaz-gly-betaol


5979:phhs-25oxaz-bala-zdapee


5980:tolhs-25thiaz-bala-beta23meoph


5981:bhs-25thiaz-gly-betahbcph


5982:ibhs-oxadiaz-gly-betahmofu


5983:ibhs-ithiadiaz-gly-betahbcph


5984:2py-25thiaz-bala-betahni


5985:tolhs-24thiaz-bala-betaipr


5986:2py-25thioph-ala-betapy


5987:ibhs-oxadiaz-gly-betabthioph


5988:ibhs-25methiaz-gly-betapym


5989:2py-24thiaz-bala-betadcph


5990:phhs-me25thioph-leu-betadcph


5991:ibhs-24thioph-gly-betainyl


5992:phhs-24thiaz-bala-betatbuph




CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-188
5993: tolhs-oxadiaz-bala-psdaptb


5994: dhim-24oxaz-ala-betapy


5995: ibhs-25methiaz-bala-betafluo


5996: gua-26py-gly-betahph


5997:phhs-25thiaz-bala-psdapee


5998: phhs-24thiaz-gly-betaol


5999: bhs-25methiaz-bala-betaol


6000: 2py-nme35pyr-gly-aspibua


6001: ibhs-25oxaz-gly-beta35dbph


6002:tolhs-nme35pyr-gly-betahb


6003: ibhs-nme35pyr-gly-betaheph


6004: bhs-25oxaz-nmgly-betamesu


6005: 2py-24oxaz-ala-betadcph


6006: ibhs-ithiadiaz-gly-betaamibe


6007:tolhs-24thioph-gly-betadcphee


6008: tolhs-25thiaz-bala-asppha


6009: bhs-24thioph-bala-betadhbfu


6010: ibhs-ithiadiaz-bala-betadbph


6011: phhs-oxadiaz-gly-betathio3


6012:bhs-nme35pyr-nmgly-ibsdap


6013: ibhs-24thiaz-gly-betamethioph


6014: ibhs-oxadiaz-bala-betathio3


6015: 2py-25oxaz-nmgly-betadcph


6016: 2py-42n meim-gly-betahcbph


6017:toihs-24thioph-gly-betahdbph


6018: ibhs-nme35pyr-gly-betahdbph


6019: ibhs-24thiaz-gly-betabthioph


6020: bhs-25oxaz-bala-betapym


6021: ibhs-25methiaz-bala-betadito


6022:bhs-25thiaz-gly-betapbiph


6023: bhs-ithiadiaz-gly-betaibph


6024: ibhs-24thiaz-gly-betahni


6025: phhs-25oxaz-bala-betameph


6026: 2py-ith iadiaz-gly-aspbzla


6027:bhs-25methiaz-gly-betathiome


6028: phhs-ithiadiaz-gly-betahdcph


6029: tolhs-nme35pyr-bala-betaheph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-189
6030:tolhs-25thiaz-bala-betabph


6031:phhs-nme35pyr-bala-betatos


6032:phhs-me25thiaz-gly-beta34meoph


6033:tolhs-25methiaz-gly-betatrif


6034:tolhs-nme35pyr-gly-betacbph


6035:bim-25oxaz-gly-aspaba


6036:bhs-nme35pyr-bala-betabnaphth


6037:ibhs-24thioph-bala-betainyl


6038:phhs-ithiadiaz-gly-betaibph


6039:tolhs-nme35pyr-gly-betaftrif


6040:ur-25thiaz-gly-betainyl


6041:bim-oxadiaz-leu-betadcph


6042:phhs-oxadiaz-gly-betaipr


6043:tolhs-25thiaz-bala-betafphe


6044:cima-24thiaz-gly-betainyl


6045:ibhs-25oxaz-gly-csdap


6046:bhs-25oxaz-bala-betathio3


6047:phhs-me25thioph-gly-betapy


6048:tolhs-me24thiaz-gly-beta34meoph


6049:bim-25oxaz-phe-betapy


6050:tolhs-25thiaz-bala-betaphethio


6051:dhim-24thiaz-ala-betainyl


6052:tolhs-oxadiaz-bala-betaet


6053:tolhs-me24thiaz-ala-zdap


6054:tolhs-25oxaz-bala-betatos


6055:ibhs-24thiaz-gly-betatrif


6056:tolhs-oxadiaz-gly-betahbcph


6057:ibhs-25oxaz-gly-betaol


6058:2py-triaz-leu-psdap


6059:phhs-nme35pyr-gly-betahmofu


6060:bhs-ithiadiaz-bala-betafphe


6061:phhs-nme35pyr-gly-busu2be


6062:tolhs-me25thioph-leu-psdap


6063:thazep-42pym-gly-betapy


6064:ibhs-oxadiaz-bala-beta13bendi


6065:tolhs-25thiaz-gly-betafu3


6066:ibhs-oxadiaz-gly-betacbph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-190
6067:gua-25thiaz-gly-betabpy


6068:phhs-nme35pyr-bala-csdap


6069:bim-53py~azo-gly-psdap


6070:ibhs-ithiadiaz-bala-betaimid


6071:bhs-52thiaz-ala-zdap


6072:ibhs-24thiaz-bala-betaheph


6073:tolhs-25oxaz-gly-betatos


6074:2py-24oxaz-bala-betadcph


6075:bhs-35thioph-leu-zdap


6076:bhs-ithiadiaz-bala-zdapch


6077:bhs-24thioph-nmgly-betaanaphth


6078:tolhs-25methiaz-gly-psdap


6079.bhs-me24oxaz-ala-betapy


6080:ibhs-25methiaz-gly-betadhbfu


6081:bhs-25thiaz-bala-ibsdap


6082:tolhs-nme35pyr-gly-betahdbph


6083:2py-42nmeim-bala-betaibph


6084:phhs-24thiaz-gly-betadbph


6085:phhs-25oxaz-bala-betafphe


6086:2py-26py-gly-zdap


6087:tolhs-oxadiaz-gly-betabthioph


6088:tolhs-25oxaz-bala-betadtrif


6089:bim-me25oxaz-leu-betaph


6090:ibhs-ithiadiaz-bala-beta34meoph


6091:phhs-nme35pyr-gly-zdaptb


6092:ibhs-24thiaz-bala-aspibua


6093:tolhs-24thioph-gly-betabpy


6094:bhs-ithiadiaz-gly-betadmoph


6095:gua-24thiaz-gly-betaphethio


6096:phhs-oxadiaz-bala-betadtrif


6097:ibhs-24thioph-bala-asppha


6098:phhs-nme35pyr-gly-betacthioph


6099:tolhs-25methiaz-bala-betaanaphth


6100:bhs-ithiadiaz-gly-betadcphch


6101:bhs-25methiaz-bala-betahni


6102:bhs-24thiaz-gly-psdapch


6103:bim-42nmeim-leu-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEPOOl03469
-191-
6104:tolhs-24thioph-bala-beta34meoph


6105:tolhs-24thiaz-bala-betafph


6106:tolhs-oxadiaz-gly-betaph


6107:phhs-ithiadiaz-gly-aspaba


6108:phhs-25oxaz-bala-ibsdap


6109.ibhs-25thiaz-gly-betabpy


6110:bhs-25methiaz-bala-betabnaphth


6111;tolhs-25oxaz-bala-betambiph


6112:tolhs-me25thioph-gly-beta34meoph


106113:tolhs-25oxaz-bala-betathiome


6114:dhim-25thioph-gly-betainyl


6115:ibhs-25oxaz-bala-aspibua


6116:phhs-oxadiaz-gly-suabu


6117:ibhs-nme35pyr-bala-beta35dbph


156118:2py-25methiaz-leu-psdap


6119:bim-thiadiaz-gly-psdap


6120:ibhs-ithiadiaz-gly-betadcphch


6121:tolhs-oxadiaz-bala-betaibph


6122:bhs-ithiadiaz-bala-betafph


206123:ibhs-oxadiaz-bala-betahdbph


6124:bhs-25thiaz-bala-betafph


6125:phhs-nme35pyr-gly-betapym


6126:ibhs-25oxaz-bala-betadcph


6127:phhs-25oxaz-bala-betahdbph


256128:tolhs-oxadiaz-bala-betadmoph


6129:tolhs-24thioph-gly-betahdcph


6130:bhs-25methiaz-bala-betaph


6131:bhs-25thiaz-gly-betapyee


6132:tolhs-25methiaz-bala-betaimid


306133:gua-42pym-gly-betathio3


6134:bhs-25methiaz-nmgly-beta23meoph


6135:sabhs-42nmeim-gly-betapy


6136:bhs-24thiaz-bala-betathioph


6137:impy-25methiaz-bala-betaphethioa


356138:bhs-nme35pyr-gly-suabu


6139:tolhs-ithiadiaz-gly-betapy


6140:phhs-oxadiaz-gly-zdaptb




CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-192-
6141: phhs-ithiadiaz-gly-betahcbph


6142: tolhs-me24oxaz-ala-psdap


6143: bhs-oxadiaz-gly-betahmph


6144: ibhs-ithiadiaz-bala-betamesu


6145: bim-52thiaz-ala-zdap


6146: bhs-24thioph-ala-beta34dcph


6147: ibhs-24thiaz-bala-ibsdap


6148: tolhs-ithiadiaz-bala-betabnaphth


6149: ibhs-oxadiaz-gly-betadcphtb


106150: tolhs-oxadiaz-bala-betafphe


6151: tolhs-nme35pyr-gly-betapytb


6152: bhs-53pyrazo-ala-betadcph


6153: 2py-26py-nmala-zdap


6154: bhs-25oxaz-gly-betaheph


156155: bhs-25thiaz-gly-betapym


6156: bhs-24thiaz-leu-betapy


6157: phhs-oxadiaz-bala-betadhbfu


6158: phhs-oxadiaz-bala-asppha


6159: bhs-25thioph-gly-betainyl


206160: tolhs-oxadiaz-gly-zdap


6161: irnpy-25thiaz-ala-betapy


6162: tolhs-25methiaz-gly-busu2be


6163: 2py-35thioph-leu-psdap


6164: phhs-25methiaz-bala-betabpy


256165: 2py-26py-gly-betabnaphth


6166: bhs-25methiaz-bala-betahbcph


6167: ibhs-24thioph-gly-betaipr


6168: bhs-oxadiaz-bala-betaimid


6169: impy-25oxaz-bala-betabdimo


306170: gua-24thiaz-gly-betapbiph


6171: tolhs-24thioph-gly-beta13bendi


6172: bhs-24thioph-bala-betabph


6173: bhs-24thiaz-bala-betaimid


6174: ibhs-24thioph-gly-betadhbfu


356175: tolhs-24thiaz-gly-betabediox


6176: phhs-25oxaz-gly-betatrif


6177: bhs-triaz-gly-zdap




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-193
6178:bhs-25thiaz-gly-beta4bph


6179:tolhs-25thiaz-bala-betabenfu


6180:bhs-24thiaz-gly-betaheph


6181:bhs-nme35pyr-leu-zdap


6182:impy-42nmeim-bala-betabpy


6183:bhs-25methiaz-bala-aspibua


6184:tolhs-25thiaz-gly-betainyl


6185:toihs-me24thioph-leu-betaph


6186:2py-ithiad iaz-g ly-zdap


6187:impy-25oxaz-gly-betafu2


6188:tolhs-me25oxaz-gly-beta34meoph


6189:thpy-24thiaz-gly-betadcph


6190:2py-25oxaz-gly-aspaba


6191:tolhs-24thiaz-bala-zdap


6192:thpym-2thioph-gly-zdap


6193:phhs-25thiaz-bala-betahcbph


6194:ibhs-25methiaz-gly-betapyr


6195:bhs-ithiadiaz-bala-betaimid


6196:2py-me25thiaz-bala-betadcph


6197:bhs-25thiaz-gly-betafbph


6198:phhs-24thiaz-gly-betahcbph


6199:phhs-25thiaz-gly-betabmph


6200:bhs-25oxaz-gly-betabenfu


6201:bhs-ithiadiaz-bala-betaanaphth


6202:bim-me24thioph-gly-betapy


6203:bhs-24thioph-ala-beta3quin


6204:tolhs-25oxaz-bala-betahdbph


6205:bhs-oxadiaz-gly-psdap


6206:bhs-25oxaz-bala-betatos


6207:ibhs-oxadiaz-bala-betapyr


6208:tolhs-me24thiaz-bala-beta34meoph


6209:2pmhs-25methiaz-gly-betameph


6210:phhs-25oxaz-gly-betah35dc


6211:hyd-42pym-gly-psdap


6212:ibhs-ithiadiaz-gly-betaet


6213:2py-me24thioph-gly-betapy


6214:phhs-24thiaz-gly-betahbcph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-194
6215: phhs-oxadiaz-bala-zdap


6216: phhs-ithiadiaz-bala-betapyr


6217: phhs-24thioph-gly-asppha


6218: bhs-24thioph-bala-betaanaphth


6219: bhs-24thiaz-bala-betahbcph


6220: 2py-25methiaz-bala-zdap


6221: bhs-ithiadiaz-gly-betadbph


6222: 2pmhs-25methiaz-gly-betahbcph


6223: bhs-ithiadiaz-gly-betabpy


106224: bim-25thiaz-bala-betafphe


6225: phhs-24thiaz-bala-betahbcph


6226: ibhs-24thiaz-bala-betaimid


6227: bhs-25thiaz-bala-betadtrif


6228: bhs-35fur-ala-zdap


156229: bhs-ithiadiaz-bala-aspaba


6230: bhs-24thiaz-bala-betapytb


6231: tolhs-25oxaz-bala-beta23meoph


6232: bim-24thioph-bala-betafphe


6233: ibhs-24thioph-bala-betadcphtb


206234: bim-triaz-leu-zdap


6235: tolhs-25methiaz-bala-aspaba


6236: bhs-25oxaz-gly-zdapee


6237: bhs-nme35pyr-bala-betadhbfu


6238: ibhs-25oxaz-gly-betainyl


256239: phhs-me24thiaz-leu-betapy


6240: phhs-nme35pyr-bala-betatrif


6241: bhs-nme35pyr-gly-betapych


6242: bim-nme35pyr-gly-psdap


6243: phhs-ithiadiaz-gly-zdapch


306244: bhs-42oxaz-gly-psdap


6245: bhs-me24thiaz-ala-psdap


6246: tolhs-25methiaz-bala-betaet


6247: bhs-me24oxaz-bala-betadcph


6248: phhs-25methiaz-bala-betaoxope


356249: bhs-oxadiaz-gly-betabthioph


6250: tolhs-25methiaz-gly-betahdbph


6251: phhs-oxadiaz-gly-betabph




CA 02371604 2001-10-24
WOOO166618 PCTlEP00103469
-195-
6252:ibhs-ithiadiaz-gly-betaphethioa


6253:tolhs-25oxaz-bala-beta35dbph


6254:tolhs-24thiaz-gly-betadbph


6255:ibhs-25oxaz-gly-betafbph


6256:impy-25thiaz-bala-betainyl


6257:2py-24thioph-gly-zdap


6258:phhs-oxadiaz-gly-psdaptb


6259:dhthi-25thiaz-bala-betadcph


6260:ibhs-24thiaz-gly-betafu3


106261:phhs-me24oxaz-ala-betadcph


6262:bhs-ithiadiaz-bala-betadtrif


6263:bhs-ithiadiaz-nmgly-beta34meoph


6264:bhs-24thiaz-gly-betapytb


6265:2py-24thioph-ala-psdap


156266:nmhs-26py-gly-betapy


6267:bim-26py-ala-psdap


6268:gua-26py-gly-betamesu


6269:2py-oxadiaz-bala-aspbzla


6270:phhs-24thioph-bala-betadcphch


206271:gua-42pym-gly-betacbph


6272:bhs-24thiaz-bala-betabpy


6273:phhs-ithiadiaz-bala-betainyl


6274:phhs-ithiadiaz-gly-betadcphch


6275:phhs-25thiaz-bala-betahph


256276:ibhs-25methiaz-bala-betapyee


6277:ibhs-24thiaz-gly-aspbzla


6278:phhs-24thiaz-bala-betaoxope


6279:ibhs-24thioph-bala-betaphethioa


6280:tolhs-ithiadiaz-gly-betamethi


306281:bim-24thiaz-gly-betainyl


6282:phhs-25oxaz-bala-betapym


6283:tolhs-me24oxaz-bala-zdap


6284:bhs-25thioph-bala-betapy


6285:tolhs-24thioph-bala-betaimid


356286:bim-25thiaz-gly-aspbzla


6287:tolhs-ithiadiaz-gly-betadtrif


6288:ibhs-24thiaz-bala-betaftrif




CA 02371604 2001-10-24
W000166618 PCTIEP00/03469
-196-
6289:2py-thiadiaz-bala-psdap


6290:phhs-25oxaz-bala-betabmph


6291:phhs-nme35pyr-gly-betahmph


6292:2py-53pyrazo-gly-betadcph


6293:bhs-me24thiaz-leu-psdap


6294:bim-24im-gly-betadcph


6295:2py-24oxaz-ala-betameph


6296:tolhs-24thiaz-gly-betahbcph


6297:phhs-25methiaz-bala-beta35dbph


6298:phhs-25thiaz-gly-betapyr


6299:ibhs-25thiaz-bala-betadbph


6300:bhs-nme35pyr-bala-betaet


6301:bim-me25thiaz-gly-zdap


6302:phhs-25thiaz-bala-betaanaphth


6303:bhs-nme35pyr-gly-betaol


6304:phhs-24thioph-bala-betadtrif


6305:phhs-me25thiaz-leu-beta34meoph


6306:ibhs-25thiaz-gly-betamethi


6307:bim-24thioph-leu-zdap


6308:bhs-ithiadiaz-bala-betathio3


6309:2pmhs-24thiaz-gly-betabpy


6310:bhs-24thiaz-gly-betapym


6311:phhs-25methiaz-gly-betampy


6312:bim-25oxaz-bala-asppha


6313:impy-42nmeim-gly-betamethioph


6314:tolhs-nme35pyr-bala-betahcbph


6315:bhs-oxadiaz-bala-betabnaphth


6316:bhs-nme35pyr-gly-betaipr


6317:ibhs-24thiaz-bala-betahc


6318:tolhs-25methiaz-gly-betaanaphth


6319:2py-me25thioph-bala-betaph


6320:tolhs-24thioph-gly-betapych


6321:ibhs-oxadiaz-gly-betabenfu


6322:phhs-25thiaz-gly-betamesu


6323:tolhs-me24thioph-bala-betaph


6324:dimethpym-26py-gly-betahdcph


6325:ibhs-25thiaz-gly-beta34meoph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-197-
6326: bim-me25thiaz-gly-betapy


6327: phhs-24thioph-gly-betapym


6328: 2py-me25thiaz-ala-beta34meoph


6329: phhs-oxadiaz-bala-betadbph


6330: ibhs-nme35pyr-bala-betafbph


6331: ibhs-25thiaz-bala-betatrif


6332: tolhs-oxadiaz-gly-betaipr


6333: bim-me25thiaz-bala-betapy


6334: bhs-25oxaz-gly-betahc


106335: ibhs-24thioph-bala-betadtrif


6336: bhs-nme35pyr-gly-betahmo


6337: 2py-52thiaz-gly-betadcph


6338: bhs-35fur-leu-betadcph


6339: dhim-26py-gly-betainyl


156340: bim-me24thiaz-ala-zdap


6341: ibhs-nme35pyr-gly-betamesu


6342: ibhs-oxadiaz-bala-aspibua


6343: tolhs-24thiaz-bala-psdapee


6344: bim-me24oxaz-bala-psdap


206345: bhs-me24thioph-gly-psdap


6346: bhs-24thioph-gly-betaet


6347: ibhs-ithiadiaz-bala-beta23meoph


6348: 2py-25thiaz-bala-suabu


6349: bhs-me24thiaz-bala-betadcph


256350: 2py-25thiaz-bala-betaet


6351: bhs-oxadiaz-gly-asppha


6352: ibhs-24thioph-bala-beta13bendi


6353: phhs-25methiaz-bala-betabnaphth


6354: 2py-25thiaz-gly-betacthioph


306355; dhim-25oxaz-bala-betadcph


6356: phhs-me24thioph-bala-psdap


6357: 2py-ithiadiaz-bala-aspibua


6358: phhs-24thioph-gly-betadmoph


6359: bhs-ithiadiaz-bala-betadcphch


356360: ibhs-24thiaz-bala-betadmoph


6361: phhs-24thioph-bala-beta4bph


6362: ibhs-25oxaz-bala-betapych




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-198-
6363: ibhs-24thioph-bala-betabph


6364: bhs-25oxaz-ala-betapy


6365: bim-25fur-leu-betapy


6366: ibhs-24thioph-bala-beta35dbph


6367: bhs-24thioph-bala-betaftrif


6368: bhs-25fur-ala-zdap


6369: bhs-25thiaz-baia-beta34meoph


6370: thazep-26py-gly-betapy


6371: bhs-nme35pyr-gly-betathio3


6372:2pmhs-25oxaz-bala-betaoxope


6373: tolhs-oxadiaz-gly-betacph


6374: phhs-25methiaz-bala-psdaptb


6375: bim-25thiaz-nmala-betadcph


6376: bim-25thiaz-bala-aspbzla


6377:bhs-24thiaz-nmgly-betafphe


6378: tolhs-ithiadiaz-gly-betaph


6379: ibhs-ithiadiaz-bala-betaol


6380: impy-24thioph-gly-betathiobe


6381: tolhs-25methiaz=gly-betacthioph


6382:ibhs-24thiaz-bala-betameph


6383: 2py-25methiaz-bala-betaet


6384: bhs-25oxaz-nmgly-beta34meoph


6385: gua-24thiaz-gly-betapy


6386: tolhs-25oxaz-bala-betahcbph


6387:bhs-42nmeim-bala-betacthioph


6388; tolhs-25methiaz-gly-betameph


6389: ibhs-25thiaz-bala-betathiome


6390: bhs-nme35pyr-bala-betathio3


6391: phhs-oxadiaz-bala-betahmofu


6392:ibhs-ithiadiaz-bala-betadmoph


6393: tolhs-24thiaz-gly-aspaba


6394: impy-25thiaz-bala-betamesu


6395: ibhs-24thiaz-gly-betaibph


6396; bhs-25oxaz-bala-betainyl


6397:bhs-25methiaz-bala-betahph


6398: gua-25thiaz-nmgly-betapy


6399: bhs-24thioph-gly-aspbzla




CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-199
6400: bhs-25oxaz-nmgly-ibsdap


6401: 2py-24im-leu-zdap


6402: phhs-nme35pyr-bala-betafbph


6403: tolhs-25oxaz-bala-zdap


6404: phhs-oxadiaz-gly-betahmofu


6405: bim-42nmeim-bala-betathiobe


6406: bhs-25oxaz-bala-zdaptb


6407: ibhs-25thiaz-gly-aspbzla


6408: bim-24oxaz-bala-betapy


106409: ibhs-25oxaz-gly-beta13bendi


6410: bhs-24thiaz-gly-betahbcph


6411: ibhs-25methiaz-bala-betapbiph


6412: tolhs-ithiadiaz-bala-betadito


6413: phhs-ithiadiaz-bala-betatrif


156414: tolhs-24thiaz-gly-betadcphch


6415: bim-25methiaz-bala-betacph


6416: phhs-25methiaz-gly-betamethioph


6417: tolhs-25methiaz-gly-betapyr


6418: bhs-ithiadiaz-gly-psdaptb


206419: ibhs-ithiadiaz-bala-betapyr


6420: phhs-24thioph-bala-betahdbph


6421: dlhim-42pym-ala-betapy


6422: bhs-25thiaz-ala-betambiph


6423: 2py-24thioph-gly-asppha


256424: phhs-24thiaz-bala-betafph


6425: 2py-24thiaz-bala-betaet


6426: tolhs-ithiadiaz-bala-betahph


6427: 2py-nme35pyr-ala-betadcph


6428: phhs-me24thioph-bala-betaph


306429: bhs-25oxaz-gly-betaoxope


6430: phhs-24thiaz-gly-betaimid


6431: tolhs-25methiaz-gly-betafphe


6432: bhs-35thioph-leu-betapy


6433: ibhs-25thiaz-bala-betadcphch


356434: toihs-25thiaz-bala-betatbuph


6435: bhs-24im-gly-betadcph


6436: 2py-26py-gly-betameph




CA 02371604 2001-10-24
W000166618 PCTIEPOOl03469
-200
6437: hs-25thioph-gly-zdap
6438: phhs-me24oxaz-gly-zdap
6439. tolhs-25oxaz-bala-betadhbfu
6440: bhs-24thioph-bala-betabdimo
6441: ibhs-ithiadiaz-bala-betahdbph
6442: phhs-24thioph-bala-betapym
6443: phhs-25methiaz-g1y-betadcphee
6444: bhs-25methiaz-gly-betahph
6445: phhs-24thiaz-bala-betaheph
6446: bhs-25oxaz-gly-betaoxaz
6447: bhs-24thiaz-bala-aspibua
6448: phhs-ithiadiaz-gly-betabthioph
6449: agua-26py-gly-betainyl
6450: phhs-24thioph-gly-betahmofu
6451: bhs-oxadiaz-bala-betatrif
6452: bhs-me24thioph-ala-betaph
6453: tolhs-25methiaz-gly-betabediox
6454: tolhs-24thioph-bala-betabediox
6455: bhs-24thioph-gly-betambiph
6456: bim-35fur-leu-betapy
6457: phhs-24thiaz-gly-csdap
6458: agua-42nmeim-gly-betapy
6459: tolhs-me24thioph-ala-psdap
6460: tolhs-ithiadiaz-bala-betabdimo
6461: tolhs-me25oxaz-gly-betaph
6462: 2py-oxadiaz-gly-asppha
6463: tolhs-25thiaz-gly-betahph
6464: bhs-nme35pyr-gly-betahdbph
6465: bhs-24thiaz-gly-ibsdap
6466: phhs-nme35pyr-gly-beta4bph
6467: bhs-25oxaz-bala-betathiome
6468: tolhs-25thiaz-bala-betaamibe
6469: tolhs-25oxaz-bala-zdapee
6470: impy-25thiaz-bala-betaftrif
6471: tolhs-25oxaz-gly-betadcphtb
6472: bhs-me24thioph-bala-psdap
6473: bhs-nme35pyr-nmgly-betathio3


CA 02371604 2001-10-24
W000/66618 PCTIEP00103469
-201
6474: bhs-oxadiaz-gly-betapym


6475: phhs-24thioph-gly-betadito


6476: ibhs-25oxaz-bala-betapbiph


6477: tolhs-nme35pyr-bala-betatrif


6478: bhs-25methiaz-bala-beta34dcph


6479: bim-25methiaz-gly-betadmph


6480: phhs-25methiaz-gly-betahc


6481: tolhs-24thiaz-bala-betah35dc


6482: bhs-me25thioph-ala-betaph


6483:tolhs-oxadiaz-gly-betahmph


6484: tolhs-25thiaz-bala-betatos


6485: tolhs-ithiadiaz-gly-betaol


6486: tolhs-24thioph-bala-betadmoph


6487: tolhs-oxadiaz-gly-betainyl


6488:phhs-25methiaz-bala-beta4bph


6489: bim-thiadiaz-ala-betadcph


6490: ur-25methiaz-gly-betadcph


6491: bim-42nmeim-nmgly-zdap


6492: tolhs-24thiaz-bala-betaph


6493:ibhs-24thioph-gly-betapyee


6494: thazep-24oxaz-gly-betainyl


6495: 4pmhs-25thiaz-bala-betameph


6496: ibhs-25methiaz-gly-suabu


6497: tolhs-25thiaz-bala-betapym


6498:bhs-oxadiaz-gly-beta23meoph


6499: tolhs-nme35pyr-gly-psdap


6500: 2pmhs-42nmeim-gly-betahmo


6501: phhs-ithiadiaz-bala-betaomebendi


6502: bhs-me24thiaz-ala-beta34meoph


6503:bhs-24thiaz-bala-beta3quin


6504: phhs-25methiaz-gly-betathioph


6505: tolhs-me25oxaz-gly-betapy


6506: phhs-24thioph-gly-betapyr


6507: tolhs-25oxaz-bala-betapym


6508:bhs-ithiadiaz-gly-betaph


6509: bim-25oxaz-leu-psdap


6510: impy-24thioph-bala-betaftrif




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-202
6511: phhs-24thioph-gly-betah35dc


6512; ibhs-24thiaz-gly-betadmoph


6513: bhs-42oxaz-ala-betapy


6514: thazep-42nmeim-bala-betameph


6515: bhs-24thiaz-bala-busu2be


6516: gua-25thiaz-gly-betahph


6517: gua-24thiaz-gly-betainyl


6518: bhs-25thiaz-gly-betahmofu


6519: phhs-nme35pyr-gly-betahmo


6520:bhs-25thiaz-gly-betaamibe


6521: phhs-24thioph-gly-betapy


6522: bhs-oxadiaz-gly-betadmph


6523: tolhs-me24oxaz-ala-betadcph


6524: thazep-25methiaz-bala-zdap


6525:tolhs-ithiadiaz-bala-aspibua


6526: phhs-me25oxaz-bala-zdap


6527: phhs-nme35pyr-gly-betadito


6528: 2py-24oxaz-bala-psdap


6529: bhs-25methiaz-bala-beta35dbph


6530:phhs-24thioph-bala-zdaptb


6531: bhs-35fur-gly-betadcph


6532: phhs-25thiaz-gly-beta34meoph


6533: phhs-25thiaz-gly-betaphethio


6534: agua-24oxaz-gly-betainyl


6535:phhs-25oxaz-bala-betahc


6536: 2py-53pyrazo-leu-zdap


6537: ibhs-25methiaz-bala-aspibua


6538: 2py-24thiaz-gly-betapy


6539: tolhs-ithiadiaz-gly-betaphethio


6540:ibhs-oxadiaz-bala-betaipr


6541: bhs-25thiaz-gly-betathio3


6542: gua-24oxaz-gly-betacbph


6543: bhs-24oxaz-gly-betapy


6544: tolhs-24thioph-bala-betafu2


6545:phhs-24thioph-gly-betamethi


6546: bhs-nme35pyr-bala-beta34dcph


6547: phhs-oxadiaz-bala-betaheph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-203
6548:2py-oxadiaz-gly-betapy


6549:bhs-25methiaz-nmgly-betameph


6550:2py-me24oxaz-ala-betadcph


6551:bim-triaz-ala-psdap


6552:ibhs-25thiaz-gly-betabenfu


6553:bim-42nmeim-bala-betapy


6554:bhs-25thiaz-gly-betabnaphth


6555:bhs-ithiadiaz-bala-betadhbfu


6556:tolhs-25thiaz-gly-betaipro


6557:dhpyrr-26py-gly-psdap


6558:bhs-24thiaz-ala-betadcph


6559:hs-25thiaz-gly-betainyl


6560:bhs-25oxaz-gly-betamethi


6561:bhs-nme35pyr-bala-beta34meoph


6562:ibhs-25methiaz-bala-betaomebendi


6563:phhs-24thioph-gly-betadcphtb


6564:ibhs-25thiaz-gly-betatbuph


6565:ibhs-oxadiaz-gly-betafluo


6566:2pmhs-24thiaz-phe-zdap


6567:ibhs-24thioph-gly-betabph


6568:2py-42nmeim-gly-betaimid


6569:ibhs-25methiaz-gly-betahni


6570:phhs-25methiaz-bala-psdapch


6571:phhs-25oxaz-gly-betabpy


6572:bhs-24thiaz-nmgly-beta13bendi


6573:ibhs-oxadiaz-gly-betabediox


6574:ibhs-nme35pyr-gly-betacph


6575:bim-24im-leu-psdap


6576:bim-25thiaz-gly-betaomebendi


6577:tolhs-oxadiaz-gly-zdapee


6578:ibhs-24thioph-gly-betahcbph


6579:ibhs-25methiaz-bala-betainyl


6580:ibhs-ithiadiaz-bala-zdapee


6581:tolhs-ithiadiaz-bala-betahc


6582:tolhs-24thioph-gly-betamesu


6583:tolhs-24thiaz-bala-suabu


6584:bhs-24im-ala-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-204
6585:gua-24thiaz-gly-beta4bph


6586:bhs-25thiaz-bala-betaipr


6587:ibhs-25oxaz-gly-betabnaphth


6588:ibhs-nme35pyr-gly-betadito


6589:bim-me25thiaz-ala-zdap


6590:bhs-24thioph-bala-zdapee


6591:ibhs-oxadiaz-giy-betafu2


6592:2py-me25thiaz-leu-betapy


6593:phhs-24thiaz-bala-betaipr


6594:tolhs-ithiadiaz-bala-betafluo


6595:ibhs-24thioph-bala-betaamibe


6596:2py-25thioph-gly-betapy


6597:bhs-25oxaz-leu-betapy


6598:tolhs-ithiadiaz-gly-betaamibe


6599:bhs-me24oxaz-leu-betadcph


6600:bhs-nme35pyr-bala-betafluo


6601:bhs-24thiaz-ala-betabpy


6602:ibhs-25methiaz-bala-betaipr


6603:bhs-24thiaz-bala-betadhbfu


6604:tolhs-25thiaz-gly-beta13bendi


6605:phhs-nme35pyr-gly-betadcphee


6606:bhs-25oxaz-gly-betabmph


6607:phhs-25methiaz-gly-betaipr


6608:tolhs-25oxaz-gly-betaftrif


6609:bhs-25oxaz-bala-betaphethioa


6610:ibhs-24thioph-gly-betaheph


6611:bhs-24thioph-gly-suabu


6612:tolhs-25methiaz-bala-betamethioph


6613:tolhs-24thioph-gly-asppha


6614:ibhs-25methiaz-bala-betaol


6615:phhs-24thiaz-bala-betapytb


6616:2pmhs-42nmeim-bala-betafu2


6617:tolhs-oxadiaz-gly-aspibua


6618:bhs-oxadiaz-nmgly-ibsdap


6619:tolhs-24thioph-gly-betapym


6620:ibhs-nme35pyr-bala-betahmofu


6621:bhs-35thioph-bala-zdap




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-205-
6622: 2pmhs-25methiaz-gly-betahb


6623: gua-26py-gly-betah35dc


6624: phhs-24thiaz-gly-betapytb


6625: bim-42nmeim-gly-betaphethioa


6626: 2py-triaz-gly-zdap


6627: bhs-24thiaz-gly-zdap


6628: bhs-24thiaz-bala-betampy


6629: bim-25oxaz-gly-asppha


6630: tolhs-ithiadiaz-bala-beta35dbph


106631: phhs-nme35pyr-bala-asppha


6632: ibhs-oxadiaz-gly-betadhbfu


6633: ibhs-ithiadiaz-bala-betadcphch


6634: 2py-ithiadiaz-gly-aspaba


6635: bhs-25oxaz-nmgly-beta3quin


156636: ibhs-25oxaz-bala-zdapee


6637: bhs-25oxaz-gly-betabthioph


6638: bhs-oxadiaz-gly-betabph


6639: phhs-oxadiaz-bala-betameph


6640: tolhs-me25thioph-bala-betapy


206641: tolhs-ithiadiaz-gly-betahdbph


6642: bim-24thiaz-gly-betadcph


6643: ibhs-nme35pyr-gly-betaphethioa


6644: tolhs-25thiaz-gly-betathio3


6645: phhs-24thioph-bala-betapych


256646: 2py-35fur-leu-betapy


6647: bhs-24chin-gly-zdap


6648: tolhs-oxadiaz-gly-betaamibe


6649: bhs-24thioph-nmgly-betahph


6650: ibhs-oxadiaz-gly-betabdimo


306651: 2py-me24oxaz-gly-beta34meoph


6652: bhs-25thiaz-gly-betaimid


6653: bim-24thiaz-ala-betadcph


6654: tolhs-25oxaz-gly-zdap


6655: bhs-ithiadiaz-gly-betacbph


356656: tolhs-nme35pyr-gly-beta13bendi


6657: 2py-thiadiaz-bala-betapy


6658: dhim-24oxaz-gly-psdap




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-206
6659: bhs-nme35pyr-bala-psdap
6660: tolhs-oxadiaz-bala-psdapee
6661: gua-25thiaz-gly-betadmoph
6662: bhs-me24thioph-ala-betadcph
6663: bhs-25methiaz-gly-betapbiph
6664: bhs-25oxaz-bala-betadcphch
6665: ibhs-ithiadiaz-bala-betadmph
6666: bim-23thioph-gly-zdap
6667: phhs-24thiaz-bala-betahb
6668: tolhs-25methiaz-gly-betapy
6669: bhs-24thioph-met-betadcph
6670: tolhs-24thioph-bala-betapych
6671: 2py-25thioph-leu-betapy
6672: ibhs-25oxaz-bala-asppha
6673: phhs-me24oxaz-bala-zdap
6674: ibhs-25oxaz-bala-betabnaphth
6675: tolhs-24thioph-gly-betapbiph
6676: bhs-ithiadiaz-leu-betapy
6677: bhs-25oxaz-bala-zdap
6678: phhs-25methiaz-gly-betahcbph
6679: tolhs-24thiaz-bala-betahmph
6680: tolhs-nme35pyr-gly-betabpy
6681: ibhs-25methiaz-gly-betaphethio
6682: tolhs-oxadiaz-bala-betahc
6683: phhs-25oxaz-bala-zdaptb
6684: ibhs-nme35pyr-bala-betabnaphth
6685: ibhs-25methiaz-gly-aspbzla
6686. tolhs-24thiaz-bala-betafluo
6687: bhs-ithiadiaz-nmgly-betacph
6688: tolhs-25oxaz-bala-betaipro
6689: bim-25thioph-leu-betapy
6690: ibhs-oxadiaz-bala-betathiobe
6691: gua-24thiaz-gly-betathiome
6692: bhs-25thioph-ala-betadcph
6693: 2py-24oxaz-ala-betapy
6694: phhs-25methiaz-bala-betahcbph
6695: ibhs-25thiaz-bala-betathioph


CA 02371604 2001-10-24
W000166618 PCTlEP0010346g
-207
6696:ibhs-25oxaz-bala-betapytb


6697:phhs-25thiaz-gly-suabu


6698:phhs-me25thioph-bala-zdap


6699:phhs-oxadiaz-gly-betahmo


6700:bhs-25thiaz-gly-betabpy


6701:phhs-24thiaz-bala-betainyl


6702:phhs-24thiaz-bala-betaph


6703:bhs-25methiaz-nmgly-betainyl


6704:bhs-nme35pyr-gly-betabpy


6705:bhs-25methiaz-bala-betadtrif


6706:phhs-24thiaz-bala-betafluo


6707:2py-25thiaz-bala-zdap


6708;2py-25oxaz-bala-asppha


6709:tolhs-25methiaz-bala-betafu2


6710:bhs-25thiaz-bala-beta34dcph


6711:2py-25oxaz-ala-betadcph


6712:bhs-25methiaz-bala-zdap


6713:phhs-oxadiaz-gly-betamethi


6714:phhs-ithiadiaz-bala-betamesu


6715:bhs-24thiaz-bala-betamethioph


6716:bhs-25oxaz-gly-betapym


6717:bhs-ithiadiaz-ala-betainyl


6718:phhs-24thioph-gly-betabmph


6719:ibhs-25methiaz-gly-betadmph


6720;ibhs-24thiaz-bala-betahmo


6721:tolhs-24thiaz-gly-beta34dcph


6722:phhs-25methiaz-gly-betaphethioa


6723:2py-me25oxaz-leu-betaph


6724:phhs-ithiadiaz-bala-betathioph


6725:bhs-me25thiaz-leu-betadcph


6726:bhs-25oxaz-bala-betaol


6727:bhs-24thiaz-nmgly-betaanaphth


6728:ibhs-24thioph-bala-betamethioph


6729:phhs-25methiaz-bala-betamethi


6730:ibhs-nme35pyr-gly-zdapee


6731:bhs-24thioph-bala-beta13bendi


6732:ibhs-25oxaz-bala-psdapch




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-208-
6733: ibhs-ithiadiaz-gly-betaoxope
6734: tolhs-25thiaz-gly-betaol
6735: tolhs-nme35pyr-gly-betadtrif
6736: bhs-26py-ala-betadcph
6737: tolhs-25thiaz-gly-betadcphtb
6738: impy-25methiaz-gly-betabediox
6739: bhs-25thioph-ala-betapy
6740: phhs-25thiaz-gly-betadito
6741: phhs-oxadiaz-gly-beta34dcph
6742: bim-25oxaz-gly-betabpy
6743: ibhs-25methiaz-bala-betadcph
6744: tolhs-25methiaz-bala-ibsdap
6745: phhs-oxadiaz-gly-betaftrif
6746: tolhs-oxadiaz-gly-betaoxaz
6747: 2py-thiadiaz-leu-zdap
6748: tolhs-me24thioph-leu-zdap
6749: ibhs-oxadiaz-bala-betaoxope
6750: bhs-ithiadiaz-gly-betaanaphth
6751: thazep-24thiaz-gly-betainyl
6752: tolhs-ithiadiaz-gly-betaipr
6753: bhs-35thioph-ala-psdap
6754: bhs-24thioph-bala-betapytb
6755: bhs-me25thiaz-ala-betapy
6756: bhs-25oxaz-gly-betaipro
6757: ibhs-25methiaz-bala-betahbcph
6758: bim-52thiaz-gly-betainyl
6759: ibhs-24thioph-bala-betafph
6760: 2py-25thioph-leu-zdap
6761: ibhs-25oxaz-bala-betaet
6762: bhs-me25thiaz-leu-betapy
6763: ibhs-25oxaz-gly-betabediox
6764: ibhs-nme35pyr-bala-betabpy
6765: phhs-24thioph-bala-betafph
6766: tolhs-25methiaz-gly-betah35dc
6767: tolhs-25oxaz-bala-aspibua
6768: 2py-oxadiaz-gly-zdap
6769: bhs-ithiadiaz-leu-psdap


CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-209-
6770:2 py-24oxaz-g ly-psd
a p


6771:bhs-46pym-gly-betameph


6772:tolhs-ithiadiaz-bala-zdapch


6773:ibhs-25oxaz-gly-betathiome


6774:bhs-25oxaz-nmgly-betadmoph


6775:tolhs-25oxaz-bala-betahbcph


6776:ibhs-25oxaz-bala-betaphethio


6777:phhs-nme35pyr-bala-betadhbfu


6778:bhs-me24thioph-ala-zdap


6779:bhs-triaz-leu-psdap


6780:ibhs-24thioph-bala-aspibua


6781:bhs-24py-gly-betapy


6782:gua-25thiaz-gly-beta4bph


6783:ibhs-oxadiaz-bala-betabdimo


6784:gua-24thiaz-gly-betambiph


6785:bhs-nme35pyr-ala-beta23meoph


6786:bhs-24thioph-bala-betatbuph


6787:bhs-nme35pyr-bala-zdap


6788:ibhs-24thioph-bala-betafphe


6789:phhs-24thiaz-bala-aspbzla


6790;ibhs-ithiadiaz-gly-aspbzla


6791:bhs-24thiaz-bala-betaol


6792:bhs-25methiaz-gly-betadtrif


6793:ibhs-25methiaz-bala-betaanaphth


6794:tolhs-25oxaz-gly-betamethi


6795:phhs-oxadiaz-bala-betahb


6796:2py-me25thiaz-bala-zdap


6797:bhs-24thiaz-gly-betainyl


6798:impy-25thiaz-bala-busu2be


6799:bhs-24thioph-gly-betadbph


6800:ibhs-oxadiaz-gly-aspibua


6801:2py-25fur-leu-zdap


6802:ibhs-25thiaz-gly-betafbph


6803:tolhs-ithiadiaz-bala-betabediox


6804:impy-24thioph-bala-betafu3


6805:phhs-25methiaz-gly-beta35dbph


6806:tolhs-me24thioph-bala-beta34meoph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-210-
6807: bhs-oxadiaz-bala-betafphe


6808: tolhs-oxadiaz-bala-betafu2


6809: cima-25thiaz-gly-betainyl


6810: bhs-25oxaz-bala-betahph


6811:ibhs-25oxaz-bala-betatos


6812: ibhs-25thiaz-bala-betacbph


6813: gua-42pym-gly-betaol


6814: tolhs-ithiadiaz-bala-psdap


6815: 2py-26py-gly-betainyl


6816:bhs-24thioph-gly-betadhbfu


6817: tolhs-ithiadiaz-bala-betabph


6818: tolhs-24thioph-bala-betaheph


6819: phhs-25thiaz-gly-betabnaphth


6820: tolhs-25thiaz-bala-betathiobe


6821:bhs-oxadiaz-ala-beta34dcph


6822: phhs-me24oxaz-leu-betaph


6823: bhs-24thiaz-nmgly-betadito


6824: phhs-oxadiaz-gly-betahni


6825: 2py-25oxaz-bala-betamesu


6826:ibhs-nme35pyr-bala-betathiobe


6827: bhs-24thioph-gly-betaheph


6828: phhs-24thiaz-gly-zdapee


6829: ibhs-nme35pyr-gly-betadcphch


6830: tolhs-24thiaz-gly-betatos


6831:tolhs-ithiadiaz-bala-betahmo


6832: bhs-me24thiaz-gly-betameph


6833: dhim-me25thiaz-ala-betameph


6834: ibhs-24thiaz-bala-betampy


6835: ibhs-25oxaz-bala-psdaptb


6836:tolhs-25thiaz-bala-betampy


6837: ibhs-nme35pyr-g!y-betampy


6838: tolhs-me25thiaz-gly-zdap


6839: tolhs-25thiaz-bala-betaftrif


6840: ibhs-24thiaz-gly-betafbph


6841:bhs-oxadiaz-ala-betadmph


6842: tolhs-oxadiaz-bala-betadito


6843: tolhs-25thiaz-bala-betamesu




CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-211
6844:tolhs-25oxaz-gly-betadcphee


6845:gua-25thiaz-gly-beta35dbph


6846:tolhs-nme35pyr-gly-betaphethio


6847:gua-24oxaz-gly-beta34dcph


6848:2py-24thiaz-ala-zdap


6849:tolhs-oxadiaz-gly-betafphe


6850:tolhs-25oxaz-gly-beta23meoph


6851:ibhs-24thiaz-bala-beta23meoph


6852:phhs-nme35pyr-gly-betahc


6853:gua-24oxaz-gly-betadmph


6854:bhs-25fur-gly-psdap


6855:bhs-24thiaz-gly-betadbph


6856:ibhs-25thiaz-gly-betabph


6857:2py-triaz-ala-psdap


6858:tolhs-ithiadiaz-bala-csdap


6859:tolhs-ithiadiaz-gly-betadito


6860:tolhs-24thiaz-gly-betapyr


6861:bhs-ithiadiaz-gly-betafluo


6862:tolhs-24thioph-gly-betafu2


6863:ibhs-24thioph-gly-betathioph


6864:2py-53pyrazo-bala-betadcph


6865:tolhs-oxadiaz-bala-betabenfu


6866.tolhs-25thiaz-bala-betahmo


6867:ibhs-oxadiaz-gly-betahb


6868:bhs-25thiaz-ala-betameph


6869:phhs-ithiadiaz-gly-betathiome


6870:phhs-oxadiaz-g1y-betadbph


6871:tolhs-25oxaz-gly-betaoxope


6872:bhs-oxadiaz-bala-betadbph


6873:bhs-ithiadiaz-bala-betadcphee


6874:bhs-me24oxaz-gly-betadcph


6875:tolhs-25thiaz-gly-betaphethioa


6876:dhim-26py-ala-betameph


6877:tolhs-oxadiaz-gly-psdap


6878:tolhs-oxadiaz-bala-betahcbph


6879:bim-24thiaz-bala-aspbzla


6880:phhs-24thioph-gly-beta34dcph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-212
6881:bim-42oxaz-leu-zdap


6882:phhs-25oxaz-bala-betathiobe


6883:tolhs-24thiaz-bala-betathio3


6884:2py-35thioph-bala-zdap


6885:bim-25fur-bala-zdap


6886:bim-me25thioph-leu-psdap


6887:ibhs-25thiaz-gly-betafu2


6888:bhs-24thiaz-gly-betaamibe


6889:2pmhs-24thiaz-gly-betameph


6890:ibhs-24thioph-gly-psdapee


6891:phhs-25methiaz-gly-psdapch


6892:ibhs-24thiaz-gly-suabu


6893:bhs-25thiaz-ala-betapy


6894:dhim-52thiaz-ala-psdap


6895:tolhs-25thiaz-gly-zdaptb


6896:ibhs-24thiaz-gly-aspibua


6897:2pmhs-42nmeim-bala-beta23meoph


6898:2py-52thiaz-gly-betapy


6899:bhs-ithiadiaz-gly-betathiome


6900:bhs-ithiadiaz-bala-betabnaphth


6901:2py-24oxaz-leu-zdap


6902:tolhs-24thioph-bala-betaphethio


6903:bhs-35fur-gly-zdap


6904:hts-25thiaz-gly-betapy


6905:2py-oxadiaz-bala-aspibua


6906:tolhs-nme35pyr-gly-betabdcph


6907:ibhs-ithiadiaz-bala-psdaptb


6908:ibhs-25methiaz-bala-betacbph


6909:2py-25oxaz-bala-busu2be


6910:bim-me25thiaz-leu-betaph


6911:phhs-25thiaz-bala-betaphethioa


6912:ibhs-ithiadiaz-bala-betafluo


6913:gua-25thioph-gly-betadcph


6914:bhs-25thiaz-bala-betaomebendi


6915:phhs-25methiaz-bala-betaet


6916:2pmhs-42nmeim-bala-betahdbph


6917:bhs-35thioph-gly-zdap




CA 02371604 2001-10-24
WOOOI66618 PCTIEP00103469
-213
6918:ibhs-oxadiaz-bala-ibsdap


6919:tolhs-24thiaz-gly-betaanaphth


6920:2py-me24oxaz-leu-betadcph


6921:phhs-25methiaz-bala-psdapee


6922:pahs-42nmeim-bala-betadcph


6923:ibhs-oxadiaz-bala-betaol


6924:ibhs-25thiaz-gly-betapych


6925:bhs-42nmeim-leu-psdap


6926:tolhs-nme35pyr-gly-betadmoph


106927:phhs-24thioph-gly-ibsdap


6928:tolhs-me25thioph-gly-psdap


6929:phhs-25oxaz-gly-betaoxope


6930:bhs-oxadiaz-gly-aspaba


6931:tolhs-25thiaz-bala-betafluo


156932:tolhs-25methiaz-gly-betahb


6933:tolhs-ithiadiaz-gly-psdapee


6934:2py-42nmeim-gly-betahc


6935:tolhs-25thiaz-gly-betaphethio


6936:bhs-ithiadiaz-bala-betamethi


206937:tolhs-25methiaz-gly-betabph


6938:bhs-24thioph-gly-betaanaphth


6939:phhs-25methiaz-gly-beta34meoph


6940:tolhs-25methiaz-gly-betadmoph


6941:bhs-24thiaz-gly-betadmph


256942:2py-24thioph-gly-beta35dbph


6943:ibhs-25oxaz-gly-betabmph


6944:bhs-ithiadiaz-bala-beta34meoph


6945:bim-42oxaz-ala-betadcph


6946:tolhs-25methiaz-gly-betathiome


306947:ibhs-nme35pyr-bala-csdap


6948:bhs-ithiadiaz-ala-betamesu


6949:thpym-26py-gly-betahdcph


6950:2py-ithiadiaz-bala-betapy


6951;tolhs-oxadiaz-gly-asppha


356952:bhs-nme35pyr-nmgly-betaanaphth


6953:phhs-25thiaz-bala-betahmo


6954:bhs-25oxaz-gly-betadhbfu




CA 02371604 2001-10-24
1N000166618 PCTIEP00/03469
-214
6955:bhs-24thiaz-nmgly-betacthioph


6956:tolhs-25thiaz-bala-ibsdap


6957:tolhs-nme35pyr-bala-beta23meoph


6958:bim-24thioph-gly-betadcph


6959:tolhs-24thioph-bala-betahc


6960:bhs-25thiaz-bala-betahcbph


6961:tolhs-24thiaz-bala-betadhbfu


6962:ibhs-25methiaz-bala-betadtrif


6963:phhs-25methiaz-bala-beta23meoph


6964:phhs-nme35pyr-bala-betampy


6965:bhs-25thiaz-gly-betahcbph


6966:bhs-ithiadiaz-ala-zdap


6967:tolhs-25thiaz-bala-betaimid


6968:phhs-25thiaz-gly-betaamibe


6969:bim-ithiadiaz-ala-betapy


6970:bhs-42pym-ala-betainyl


6971:tolhs-25thiaz-bala-betafu2


6972:2pmhs-24thioph-gly-betathiome


6973:imhs-24thiaz-giy-zdap


6974:dhim-52thiaz-gly-betapy


6975:tolhs-24thioph-bala-betamesu


6976:phhs-ithiadiaz-bala-betahmo


6977:gua-25thiaz-gly-betaibph


6978:ibhs-24thiaz-bala-betadito


6979:phhs-nme35pyr-gly-betambiph


6980:dhpyrr-25thioph-gly-betapy


6981:bhs-25thiaz-nmgly-beta13bendi


6982:bhs-42nmeim-gly-betaoxope


6983:bim-42pym-ala-betadcph


6984:tolhs-me24thioph-leu-psdap


6985:2py-42nmeim-leu-betapy


6986:phhs-oxadiaz-bala-betamesu


6987:tolhs-24thioph-bala-aspaba


6988:dhim-26py-ala-zdap


6989:bhs-oxadiaz-bala-betampy


6990:ibhs-25thiaz-bala-betamethioph


6991:2py-42pym-gly-betameph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-215-
6992:tolhs-ithiadiaz-bala-betadmph


6993:gua-24thiaz-gly-betahmo


6994:bhs-ithiadiaz-bala-betapym


6995:bhs-24thioph-ala-betacthioph


6996:bhs-24thiaz-bala-beta.hph


6997:phhs-ithiadiaz-gly-betadito


6998:phhs-me24oxaz-ala-betapy


6999:bhs-52thiaz-ala-betapy


7000:bhs-me25oxaz-ala-zdap


107001:ibhs-25oxaz-bala-betabenfu


7002:phhis-24thiaz-bala-beta34dcph


7003:ibhs-24thiaz-bala-betadcphch


7004:ibhs-25thiaz-gly-betatrif


7005:ibhs-oxadiaz-gly-betahbcph


157006:bhs-nme35pyr-bala-betaimid


7007:bhs-oxadiaz-bala-betaamibe


7008:phhs-25oxaz-bala-betafu2


7009:tolhs-24thioph-gly-betahbcph


7010:2py-25fur-bala-betapy


207011:2py-25oxaz-bala-betainy)


7012:tolhs-me25thiaz-leu-betaph


7013:bhs-ithiadiaz-bala-betadmph


7014:bhs-nme35pyr-gly-busu2be


7015:bhs-me24thiaz-gly-betadcph


257016:tolhs-oxadiaz-bala-suabu


7017:bhs-24thioph-ala-beta34meoph


7018:tolhs-24thiaz-bala-betabnaphth


7019:ibhs-25methiaz-gly-zdapee


7020:tolhs-24thiaz-bala-betacbph


307021:bhs-25thiaz-bala-betahni


7022:ibhs-oxadiaz-bala-betaheph


7023:phhs-25thiaz-bala-betapbiph


7024:ibhs-25oxaz-gly-betafu3


7025;tolhs-24thioph-bala-betadcph


357026:2py-me25thiaz-bala-beta34meoph


7027:tolhs-ithiadiaz-gly-betaomebendi


7028:tolhs-24thiaz-bala-psdapch




CA 02371604 2001-10-24
W000/66618 PCT/EP00103469
-216
7029; phhs-nme35pyr-bala-beta23meoph


7030: bhs-24thioph-gly-betadcphch


7031: phhs-nme35pyr-gly-betafph


7032: tolhs-24thioph-bala-betadcphtb


7033: bhs-nme35pyr-bala-betadmph


7034: bhs-oxadiaz-gly-betadcphtb


7035: phhs-ithiadiaz-gly-betapyr


7036: dhim-24thiaz-gly-betameph


7037: bgua-24thiaz-gly-betameph


107038: bhs-24thiaz-ala-betapy


7039: tolhs-24thiaz-bala-betaet


7040: ibhs-25thiaz-gly-betadbph


7041: 2py-26py-gly-betaanaphth


7042: bhs-25oxaz-bala-betadhbfu


157043: phhs-25oxaz-gly-betamethi


7044: bim-24im-gly-psdap


7045: tolhs-25oxaz-gly-betadhbfu


7046: gua-24oxaz-gly-betahb


7047: phhs-oxadiaz-bala-betaph


207048: ibhs-24thioph-bala-betaomebendi


7049: bhs-24thiaz-ala-beta3quin


7050: bhs-25oxaz-bala-beta34meoph


7051: ibhs-25methiaz-gly-beta4bph


7052: bhs-nme35pyr-bala-betapbiph


257053: phhs-25methiaz-bala-psdap


7054: bhs-25methiaz-bala-betahcbph


7055: bhs-oxadiaz-gly-betafu3


7056: phhs-oxadiaz-bala-betaanaphth


7057: 2py-42nmeim-gly-zdap


307058: bhs-53pyrazo-leu-betadcph


7059: ibhs-25oxaz-bala-betahcbph


7060: gua-24thiaz-gly-betaol


7061: ibhs-nme35pyr-bala-aspaba


7062: impy-42nmeim-gly-betathioph


357063: tolhs-24thioph-bala-betahph


7064: bhs-24thiaz-bala-betamesu


7065: phhs-nme35pyr-giy-betathio3




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-217
7066: 2py-24thioph-bala-betapy
7067: phhs-25thiaz-gly-betadcphch
7068: phhs-ithiadiaz-gly-betabdimo
7069: bim-me24thioph-ala-betadcph
7070: phhs-25methiaz-bala-zdaptb
7071: tolhs-25oxaz-gly-betafbph
7072: bgua-25thiaz-gly-betameph
7073: thazep-25thioph-gly-betadcph
7074: 2py-me24oxaz-gly-zdap
7075: tolhs-24thioph-gly-betadtrif
7076: tolhs-ithiadiaz-gly-betal3bendi
7077: bhs-me25thioph-bala-psdap
7078: ibhs-nme35pyr-bala-betampy
7079: phhs-25oxaz-gly-betahni
7080: tolhs-24thioph-gly-betambiph
7081: 2py-25thiaz-hphe-psdap
7082: tolhs-25oxaz-bala-zdapch
7083: tolhs-nme35pyr-bala-beta3quin
7084: ibhs-25oxaz-bala-betahmph
7085: phhs-nme35pyr-gly-betadcphtb
7086: bhs-nme35pyr-gly-betadmph
7087: phhs-25methiaz-gly-betadmph
7088: ibhs-nme35pyr-gly-beta3quin
7089: ibhs-24thiaz-bala-betaibph
7090: bhs-25oxaz-bala-busu2be
7091: dhim-42pym-gly-zdap
7092: tolhs-25methiaz-bala-betatos
7093: phhs-nme35pyr-gly-beta13bendi
7094: bhs-24thioph-gly-betabph
7095: tolhs-oxadiaz-Bata-betaphethioa
7096: ibhs-nme35pyr-gly-betathiome
7097: bhs-oxadiaz-bala-betamesu
7098: bhs-oxadiaz-gly-zdapee
7099: phhs-oxadiaz-gly-beta3quin
7100: ibhs-25methiaz-gly-betaipr
7101: ibhs-nme35pyr-bala-betaphethioa
7102: gua-24oxaz-gly-betaol


CA 02371604 2001-10-24
W000166618 PCT/EP00103469
-218-
7103: tolhs-24thiaz-bala-betapyee


7104: bhs-ithiadiaz-nmgly-betacthioph


7105: phhs-oxadiaz-gly-betadcphtb


7106: tolhs-ithiadiaz-gly-betabnaphth


7107: ibhs-25oxaz-bala-betabmph


7108: bim-52thiaz-ala-psdap


7109: tolhs-25methiaz-gly-betamesu


7110: hyd-25oxaz-gly-betapy


7111: bhs-24thioph-bala-betapyee


7112:2py-26py-ala-betameph


7113: bim-25methiaz-gly-aspbzla


7114: ibhs-nme35pyr-gly-betadmph


7115: bim-25thiaz-bala-betadcph


7116: tolhs-24thioph-gly-betatrif


7117:phhs-24thiaz-giy-betamethioph


7118: tolhs-me24thiaz-ala-betadcph


7119: phhs-oxadiaz-gly-betadito


7120: tolhs-ithiadiaz-gly-beta34meoph


7121: bhs-ithiadiaz-gly-zdaptb


7122:impy-24thioph-bala-betah35dc


7123: ibhs-25oxaz-bala-betadbph


7124: 2py-25thioph-gly-betameph


7125: bim-25methiaz-bala-betahc


7126: tolhs-me24thioph-gly-betaph


7127:tolhs-oxadiaz-gly-betaftrif


7128: ibhs-oxadiaz-gly-betathiobe


7129: tolhs-nme35pyr-gly-beta35dbph


7130: ibhs-nme35pyr-bala-ibsdap


7131: phhs-25oxaz-gly-betahmph


7132:bhs-oxadiaz-ala-betadhbfu


7133: impy-25thiaz-bala-betamethi


7134: ibhs-nme35pyr-bala-psdapch


7135: bhs-me25oxaz-ala-psdap


7136: bhs-ithiadiaz-nmgly-betahph


7137:bhs-oxadiaz-ala-betacthioph


7138: dhim-26py-phe-zdap


7139: bhs-24thioph-bala-betah35dc




CA 02371604 2001-10-24
WOOOlfififi18 PCTIEP001034fi9
-219
7140:bhs-oxadiaz-bala-busu2be


7141:ibhs-25thiaz-gly-betaol


7142:bhs-oxadiaz-bala-betatbuph


7143:ibhs-nme35pyr-bala-betaipro


7144:bhs-me24thioph-leu-betaph


7145:ibhs-24thioph-gly-betampy


7146:phhs-oxadiaz-gly-psdap


7147:bhs-nme35pyr-gly-betamethioph


7148:bhs-25methiaz-baia-betathio3


7149:tolhs-24thiaz-bala-betainyl


7150:phhs-me25thioph-leu-beta34meoph


7151:2py-me25thiaz-leu-psdap


7152:bhs-ithiadiaz-bala-aspbzla


7153:thpy-42nmeim-gly-psdap


7154:phhs-24thioph-gly-betainyl


7155:phhs-25methiaz-gly-betambiph


7156:ibhs-nme35pyr-gly-suabu


7157:bhs-oxadiaz-gly-betameph


7158:impy-24thiaz-gly-beta34meoph


7159:ibhs-nme35pyr-bala-betatbuph


7160:ibhs-24thioph-gly-busu2be


7161:bhs-24thioph-gly-betamesu


7162:tolhs-ithiadiaz-gly-zdap


7163:gua-25thiaz-gly-betameph


7164:ibhs-nme35pyr-gly-betacthioph


7165:bhs-24im-leu-psdap


7166:ibhs-24thiaz-bala-betacbph


7167:bhs-oxadiaz-bala-betahni


7168:tolhs-24thiaz-gly-betapyee


7169:ibhs-24thioph-bala-betapyr


7170:phhs-nme35pyr-gly-beta34meoph


7171:bhs-24thiaz-ala-betadito


7172:bim-42nmeim-bala-betabthioph


7173:bhs-24thiaz-bala-betacbph


7174:ibhs-nme35pyr-bala-betabph


7175:phhs-ithiadiaz-gly-betahmph


7176:tolhs-ithiadiaz-bala-psdaptb




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-220
7177: ibhs-25oxaz-bala-betadmoph


7178: tolhs-me24oxaz-ala-zdap


7179: ibhs-ithiadiaz-bala-betahcbph


7180:, ibhs-25methiaz-bala-betathioph


7181: tolhs-25methiaz-gly-psdaptb


7182: tolhs-25oxaz-bala-betaph


7183: bhs-25thiaz-ala-betadmph


7184: bhs-24oxaz-bala-betadcph


7185: ibhs-24thioph-bala-psdapee


7186:bhs-ithiadiaz-gly-betapyr


7187: bhs-42nmeim-bala-betadito


7188: bim-24thiaz-bala-asppha


7189: bhs-24thiaz-gly-beta23meoph


7190: bhs-nme35pyr-nmgly-betacph


7191:bhs-24oxaz-leu-betapy


7192: impy-24thiaz-bala-betaphethioa


7193: phhs-ithiadiaz-gly-asppha


7194: phhs-25methiaz-gly-betapyr


7195: phhs-24thioph-gly-betaph


7196:dhim-26py-ala-psdap


7197: ibhs-24thioph-bala-betafu3


7198: ibhs-ithiadiaz-bala-betahb


7199: bhs-ithiadiaz-gly-betaomebendi


7200: phhs-25oxaz-bala-betabenfu


7201:tolhs-25thiaz-bala-betaipro


7202: phhs-25oxaz-bala-beta13bendi


7203: tolhs-oxadiaz-gly-betahc


7204: ibhs-25thiaz-bala-betadcphtb


7205: bhs-me24oxaz-bala-psdap


7206:ibhs-nme35pyr-bala-zdapee


7207: phhs-24thioph-bala-betainyl


7208: ibhs-24thioph-gly-zdap


7209: bhs-25methiaz-ala-betaanaphth


7210: tolhs-24thioph-gly-betapyee


7211:phhs-25thiaz-bala-ibsdap


7212: tolhs-24thiaz-gly-betabenfu


7213: bhs-oxadiaz-ala-beta23meoph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-221-
7214.bhs-25methiaz-ala-beta3quin


7215:phhs-25thiaz-gly-betaimid


7216:ibhs-nme35pyr-bala-beta34dcph


7217:ibhs-oxadiaz-gly-betahcbph


7218:ibhs-nme35pyr-gly-aspbzla


7219:2py-25oxaz-a.la-betapy


7220:gua-24thiaz-gly-betahdbph


7221:phhs-nme35pyr-bala-betaph


7222:bhs-nme35pyr-bala-betahdbph


107223:bhs-24thiaz-gly-betafph


7224:tolhs-25thiaz-bala-zdapch


7225:ibhs-24thiaz-gly-betapy


7226:tolhs-nme35pyr-bala-betadito


7227:phhs-25thiaz-bala-betafluo


157228:tolhs-24thiaz-gly-betaimid


7229:bhs-oxadiaz-gly-betafphe


7230:tolhs-me24thiaz-giy-betaph


7231:bim-53pyrazo-leu-psdap


7232:thazep-26py-gly-betainyl


207233:tolhs-nme35pyr-bala-betafluo


7234:tolhs-25methiaz-bala-betal3bendi


7235:bhs-25thioph-bala-psdap


7236:2pmhs-24thiaz-gly-betathiome


7237:2py-25oxaz-gly-betabthioph


257238:bhs-25thiaz-bala-betaoxope


7239:bhs-25oxaz-gly-betapych


7240:ibhs-25oxaz-gly-betahmph


7241:bhs-25oxaz-gly-betaet


7242:gua-26py-gly-betainyl


307243:bim-53pyrazo-gly-betadcph


7244:2py-25oxaz-bala-aspaba


7245:bhs-me25thioph-bala-betadcph


7246:ibhs-25methiaz-bala-betabpy


7247:bhs-24oxaz-gly-psdap


357248:bhs-25thiaz-bala-zdapch


7249:tolhs-24thiaz-bala-betaimid


7250:ibhs-24thioph-gly-beta34meoph




CA 02371604 2001-10-24
W000166618 PCTlEP00103469
-222-
7251:tolhs-25methiaz-bala-betaipr


7252:bhs-nme35pyr-bala-betadcphee


7253:tolhs-oxadiaz-gly-betabph


7254:gua-24thiaz-gly-betaheph


7255:tolhs-nme35pyr-gly-zdaptb


7256:ibhs-25oxaz-bala-betahmo


7257:bim-me25oxaz-leu-beta34meoph


7258:2 py-24 i m-al a-beta
py


7259:bhs-24thiaz-nmgly-betainyl


107260:phhs-25thiaz-bala-betaipr


7261:bhs-24thiaz-gly-asppha


7262:2py-53pyrazo-leu-betadcph


7263:bhs-me24thioph-bala-betadcph


7264:dhim-26py-gly-betameph


157265:bhs-nme35pyr-ala-betamesu


7266:ibhs-25oxaz-gly-betabpy


7267:bhs-thiadiaz-gly-psdap


7268:bim-25methiaz-leu-zdap


7269:phhs-24thiaz-bala-betabnaphth


207270:ibhs-nme35pyr-gly-betadmoph


7271:2py-25th iaz-bala-betaheph


7272:dhpyrr-24thioph-gly-betapy


7273:phhs-me24thiaz-gly-betadcph


7274:tolhs-24thioph-gly-betahc


257275:bhs-24thiaz-gly-betahdbph


7276:bim-25oxaz-gly-betaph


7277:bim-nme35pyr-bala-aspbzla


7278:tolhs-nme35pyr-gly-zdap


7279:bhs-25methiaz-bala-psdapee


307280:2py-me24thiaz-leu-betapy


7281:bhs-oxadiaz-nmgly-beta3quin


7282:tolhs-24thiaz-gly-betahph


7283:bhs-25thiaz-phg-betameph


7284:tolhs-me25oxaz-leu-betapy


357285:2py-24thioph-bala-betafluo


7286:tolhs-25oxaz-bala-betaheph


7287:ibhs-25thiaz-bala-betabenfu




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-223
7288:phhs-nme35pyr-gly-ibsdap


7289:ibhs-24thioph-bala-betamethi


7290:ibhs-24thioph-bala-betaphethio


7291:ibhs-24thioph-gly-suabu


7292:bhs-25methiaz-bala-betabph


7293:2py-25methiaz-bala-betabnaphth


7294:tolhs-24thioph-bala-betahni


7295:bhs-nme35pyr-gly-betainyl


7296:ibhs-25methiaz-gly-betadito


7297:impy-25methiaz-gly-betacbph


7298:ibhs-oxadiaz-giy-betafphe


7299:bhs-oxadiaz-gly-betambiph


7300:bhs-nme35pyr-ala-betathio3


7301:bhs-25methiaz-gly-betapytb


7302:2py-25oxaz-bala-zdap


7303:phhs-24thiaz-gly-betahmo


7304:bim-24thioph-ala-psdap


7305:bim-me24oxaz-ala-betadcph


7306:bhs-24thioph-gly-betafu2


7307:ibhs-25thiaz-gly-betapytb


7308:ibhs-24thioph-bala-betameph


7309:phhs-oxadiaz-gly-betafu3


7310:ibhs-25thiaz-gly-betambiph


7311:ibhs-oxadiaz-gly-betathioph


7312:phhs-25methiaz-bala-betahbcph


7313:bim-24thiaz-gly-zdap


7314:bhs-25fur-baia-betadcph


7315:tolhs-oxadiaz-bala-betatrif


7316:bhs-24im-bala-betadcph


7317:tolhs-25methiaz-bala-zdap


7318:phhs-ithiadiaz-gly-betadcphee


7319:ibhs-25methiaz-bala-betaftrif


7320:tolhs-nme35pyr-gly-betapy


7321:phhs-25methiaz-gly-betabmph


7322:dhthi-42nmeim-baia-psdap


7323:tolhs-24thiaz-bala-beta34dcph


7324:tolhs-me25thiaz-leu-zdap




CA 02371604 2001-10-24
WOOOI66618 PCTlEP00103469
-224-
7325:2py-me25thiaz-bala-betaph


7326:bhs-25methiaz-ala-zdap


7327:bhs-24thioph-nmgly-betadmph


7328:bhs-24thiaz-leu-zdap


7329:ibhs-24thiaz-bala-betabdimo


7330:tolhs-25oxaz-gly-psdaptb


7331:phhs-me24thioph-ala-beta34meoph


7332:bim-25thiaz-phg-zdap


7333:ibhs-24thiaz-gly-betapym


7334:bim-me25thiaz-ala-betapy


7335:2py-42oxaz-bala-betapy


7336:bim-42oxaz-gly-betapy


7337:bhs-25oxaz-gly-betapytb


7338:bhs-25oxaz-gly-betapyee


7339:gua-42pym-gly-betabdimo


7340:bhs-26py-gly-betameph


7341:impy-26py-gly-psdap


7342:bhs-25oxaz-bala-betabediox


7343:tolhs-oxadiaz-bala-zdapee


7344:bhs-nme35pyr-gly-betathiobe


7345:tolhs-25methiaz-gly-betaomebendi


7346:ibhs-24thioph-bala-betampy


7347:ibhs-24thiaz-bala-betapbiph


7348:ibhs-24thioph-bala-psdapch


7349:phhs-24thiaz-bala-betaet


7350:bhs-25methiaz-bala-betaoxaz


7351:bhs-me24thioph-leu-betadcph


7352:2py-25thioph-bala-betadcph


7353:tolhs-ithiadiaz-gly-betathiobe


7354:bhs-25methiaz-bala-betathiome


7355:bhs-oxadiaz-gly-betaoxope


7356:bhs-24thiaz-bala-betabnaphth


7357:phhs-nme35pyr-bala-betahph


7358:ibhs-25thiaz-gly-zdaptb


7359:bhs-oxadiaz-ala-betahph


7360:ibhs-42nmeim-gIy-betameph


7361:ibhs-24thioph-bala-betaol




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-225
7362:tolhs-24thioph-bala-betah35dc


7363:ibhs-24thiaz-gly-betadcphtb


7364:bhs-25thiaz-gly-betabenfu


7365:tolhs-ithiadiaz-bala-betaoxope


7366:ibhs-oxadiaz-gly-betaheph


7367:bhs-24thiaz-ala-betacthioph


7368:ibhs-24thioph-gly-betapbiph


7369:bhs-oxadiaz-nmgly-betathio3


7370:bim-me25thiaz-ala-betaph


7371:ibhs-oxadiaz-gly-betahph


7372:gua-42pym-gly-betampy


7373:tolhs-25oxaz-gly-betafu2


7374:phhs-nme35pyr-bala-betaoxope


7375:ibhs-nme35pyr-bala-betaimid


7376:bhs-25oxaz-gly-psdapee


7377:bhs-25thiaz-nmgly-betacph


7378:tolhs-24thioph-bala-aspbzla


7379:ibhs-25methiaz-gly-psdapee


7380:tolhs-25thiaz-gly-betafph


7381:phhs-ithiadiaz-gly-betaphethio


7382:ibhs-ithiadiaz-bala-betafu3


7383:ibhs-25oxaz-bala-betadcphee


7384:phhs-25methiaz-gly-betaanaphth


7385:phhs-ithiadiaz-gly-zdapee


7386:bim-ithiadiaz-gly-aspibua


7387:phhs-25oxaz-bala-betaheph


7388:tolhs-25methiaz-gly-zdaptb


7389:bhs-oxadiaz-ala-betainyl


7390:tolhs-24thioph-gly-ibsdap


7391:2py-nme35pyr-gly-zdap


7392:bim-24thiaz-bala-betahc


7393:2py-me25thioph-bala-zdap


7394:imhs-25oxaz-bala-psdap


7395:bhs-24thioph-bala-betahni


7396:tolhs-24thioph-gly-betaet


7397:ibhs-25thiaz-gly-betahdbph


7398:phhs-nme35pyr-gly-psdapee




CA 02371604 2001-10-24
W0001666'18 PCTIEP00103469
-226-
7399:phhs-oxadiaz-gly-betahbcph


7400;hyd-24thioph-bala-betameph


7401:phhs-25thiaz-bala-busu2be


7402:tolhs-24thioph-gly-betahph


7403:2py-24thioph-bala-betaheph


7404:tolhs-nme35pyr-bala-beta13bendi


7405:bhs-ithiadiaz-gly-betahb


7406:bhs-oxadiaz-bala-betaibph


7407:ibhs-25methiaz-gly-betafphe


7408:phhs-24thiaz-gly-betahph


7409:2py-24thioph-leu-psdap


7410:phhs-nme35pyr-bala-betadcphtb


7411:ibhs-24thiaz-gly-betadcphch


7412:2py-24thiophme-ala-betapy


7413:bhs-24thioph-bala-psdaptb


7414:ibhs-25methiaz-bala-betabenfu


7415:2py-ithiadiaz-leu-betapy


7416:bim-42nmeim-leu-psdap


7417:gua-42pym-gly-betahmph


7418:phhs-25methiaz-gly-betabpy


7419:tolhs-24thioph-gly-betaamibe


7420:bhs-25oxaz-bala-psdapee


7421:2pmhs-25methiaz-bala-betamethioph


7422:dimethpym-24thiaz-gly-betahdcph


7423:bhs-24thiaz-bala-betah35dc


7424:tolhs-24thioph-bala-betabenfu


7425:bim-24thioph-ala-betadcph


7426:phhs-25methiaz-bala-betamesu


7427:bhs-nme35pyr-bala-betathiobe


7428:phhs-ithiadiaz-gly-zdap


7429:phhs-ithiadiaz-bala-betameph


7430:tolhs-nme35pyr-bala-betambiph


7431:bhs-35fur-leu-betapy


7432:phhs-25thiaz-gly-betaanaphth


7433:bhs-me24thiaz-gly-betaph


7434:bhs-25methiaz-bala-betameph


7435:ibhs-nme35pyr-bala-psdaptb




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-227-
7436:phhs-me24thioph-bala-beta34meoph


7437:bhs-25thiaz-gly-betaomebendi


7438:bhs-25thiaz-gly-betadbph


7439:bhs-25methiaz-gly-betamethi


7440:gua-24oxaz-gly-betaet


7441:phhs-24thioph-gly-suabu


7442:bhs-42nmeim-bala-beta35dbph


7443:ibhs-25thiaz-gly-betahmo


7444:bhs-24thiaz-gly-zdapee


107445:ibhs-24thiaz-bala-betahdbph


7446:ibhs-24thioph-gly-betahb


7447:bim-25oxaz-gly-betadtrif


7448:bhs-24thioph-ala-betahph


7449:bhs-25oxaz-leu-psdap


157450:bhs-nme35pyr-bala-betainyl


7451:bhs-ithiadiaz-ala-beta3quin


7452:phhs-24thiaz-bala-betahdcph


7453:bim-me25thiaz-leu-betapy


7454:2py-25thiaz-gly-betainyl


207455:tolhs-25oxaz-gly-beta13bendi


7456:tolhs-24thiaz-bala-beta4bph


7457:tolhs-ithiadiaz-bala-betampy


7458:bhs-25oxaz-gly-betafphe


7459:tolhs-ithiadiaz-bala-betahmph


257460:ibhs-25thiaz-gly-betaphethioa


7461:ibhs-24thioph-bala-betacph


7462:bhs-25methiaz-bala-betaamibe


7463:phhs-me25thioph-leu-psdap


7464:2py-me25thiaz-leu-beta34meoph


307465:ibhs-ithiadiaz-bala-betaamibe


7466:phhs-oxadiaz-bala-betaoxaz


7467:phhs-nme35pyr-gly-betaphethioa


7468:bhs-24thiaz-gly-betabpy


7469:tolhs-ithiadiaz-bala-betamethioph


357470.bim-24oxaz-leu-psdap


7471:bhs-thiadiaz-leu-psdap


7472:2py-oxadiaz-gly-aspaba




CA 02371604 2001-10-24
W~00166618 PCTlEP00I03469
-228-
7473:2py-42nmeim-gly-psdap


7474:impy-25methiaz-gly-betathiobe


7475:tolhs-25oxaz-bala-betampy


7476:ibhs-25oxaz-bala-aspbzla


7477:ibhs-25thiaz-bala-betaamibe


7478:phhs-24thioph-gly-betabmph


7479:ibhs-25thiaz-bala-betaet


7480:ibhs-25methiaz-bala-betaoxope


7481:bhs-nme35pyr-bala-betaibph


107482:tolhs-25oxaz-gly-betapbiph


7483:2py-25methiaz-bala-suabu


7484:tolhs-ithiadiaz-gly-betadcph


7485:2pmhs-42nmeim-gly-betaoxaz


7486:ibhs-25methiaz-bala-psdaptb


157487:bhs-25methiaz-bala-betaomebendi


7488:impy-25oxaz-gly-beta23meoph


7489:bhs-nme35pyr-gly-psdaptb


7490:bhs-24thioph-gly-betacph


7491:bhs-25oxaz-bala-aspibua


207492:tolhs-nme35pyr-bala-zdapee


7493:bhs-25methiaz-bala-betamesu


7494:2py-42oxaz-leu-betadcph


7495:ibhs-25thiaz-gly-betadmoph


7496:bhs-nme35pyr-bala-betaipro


257497:bim-42nmeim-gly-betainyl


7498:phhs-nme35pyr-gly-betaph


7499:tolhs-25methiaz-bala-betafph


7500:tolhs-24thioph-bala-psdap


7501:bhs-25thioph-ala-betameph


307502:tolhs-25oxaz-bala-betaoxaz


7503:phhs-25thiaz-bala-betahmofu


7504:bim-24thioph-gly-asppha


7505:phhs-25oxaz-bala-betatbuph


7506:bhs-oxadiaz-ala-betamesu


357507:ibhs-24thioph-gly-betabthioph


7508:2pmhs-24thiaz-bala-betahph


7509:phhs-25oxaz-gly-betabthioph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-229
7510:phhs-24thioph-bala-betaoxope


7511:bhs-ithiadiaz-bala-ibsdap


7512:ibhs-25thiaz-gly-zdapee


7513:bhs-25oxaz-bala-betafbph


7514:tolhs-25oxaz-gly-betabthioph


7515:bhs-me25thioph-bala-beta34meoph


7516:impy-25methiaz-gly-betaipr


7517:phhs-25thiaz-gly-betadcphtb


7518:bhs-24thiaz-bala-betaipr


107519:tolhs-24thioph-gly-psdapch


7520:bhs-me24oxaz-gly-betapy


7521:phhs-nme35pyr-bala-betathio3


7522:bhs-nme35pyr-gly-betabenfu


7523:phhs-25methiaz-bala-betadito


157524:ibhs-nme35pyr-bala-betadcphtb


7525:tolhs-24thioph-gly-aspaba


7526:2py-35thioph-bala-psdap


7527:bim-me25thiaz-bala-psdap


7528:gua-25thioph-gly-beta3quin


207529:gua-42pym-gly-betathiome


7530:phhs-25methiaz-gly-beta23meoph


7531:phhs-25thiaz-gly-betadbph


7532:tolhs-24thiaz-gly-ibsdap


7533;bim-25oxaz-ala-betadcph


257534:2py-25thiaz-bala-psdap


7535:phhs-ithiadiaz-bala-betahbcph


7536:ibhs-ithiadiaz-gly-betahmo


7537:bhs-25oxaz-gly-betadito


7538:2pmhs-25oxaz-gly-betacthioph


307539:bhs-me25thiaz-ala-beta34meoph


7540:ibhs-25thiaz-gly-betahmph


7541:bhs-nme35pyr-bala-betahc


7542:tolhs-24thioph-bala-busu2be


7543:ibhs-nme35pyr-gly-betahph


357544:bim-24thioph-gly-betaanaphth


7545:phhs-oxadiaz-bala-csdap


7546:phhs-25thiaz-gly-psdaptb




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-230
7547:bim-24oxaz-leu-betadcph


7548:phhs-24thiaz-bala-betahc


7549:phhs-25methiaz-bala-aspaba


7550:tolhs-25oxaz-gly-betacph


7551:bhs-24thiaz-gly-betahni


7552:ibhs-25oxaz-gfy-busu2be


7553:bhs-24thiaz-bala-betahmofu


7554:phhs-25oxaz-bala-betaipro


7555:impy-24thiaz-gly-betacbph


7556:ibhs-25methiaz-bala-betafph


7557:tofhs-24thiaz-gly-betathiobe


7558:ibhs-ithiadiaz-bala-beta4bph


7559:bhs-24thiaz-bala-betambiph


7560:gua-24thiaz-gly-betathiobe


7561:bgua-24thiaz-gly-betapy


7562:tolhs-ithiadiaz-bala-betathioph


7563:bhs-42pym-gly-betacph


7564:phhs-ithiadiaz-bala-betadito


7565:bhs-nme35pyr-bala-aspaba


7566:bhs-24thioph-bala-betaipr


7567:ibhs-24thioph-bala-betaanaphth


7568;dhpyrr-26py-gly-betapy


7569:tolhs-25methiaz-bala-betaomebendi


7570:bhs-ithiadiaz-bala-betahph


7571:bhs-nm35pyr-gly-beta4bph


7572:bim-oxadiaz-gly-aspbzla


7573:phhs-25thiaz-bala-betabnaphth


7574:phhs-24thioph-gly-betaipro


7575:phhs-25thiaz-gly-beta4bph


7576:ibhs-25thiaz-bala-betathio3


7577:ibhs-25thiaz-bala-betabpy


7578:phhs-oxadiaz-bala-beta34dcph


7579:bhs-25oxaz-bala-betaomebendi


7580:tolhs-24thiaz-gly-betamethioph


7581:2py-42nmeim-bala-betapbiph


7582:ibhs-oxadiaz-gly-beta35dbph


7583:bhs-nme35pyr-bala-beta23meoph




CA 02371604 2001-10-24
W000166618 PCTIEP00/03469
-231
7584: tolhs-nme35pyr-gly-betabthioph


7585: tolhs-oxadiaz-gly-betabmph


7586: bhs-25thiaz-ala-betadcph


7587: 2py-42pym-ala-betameph


7588: bhs-24thiaz-bala-betameph


7589: ibhs-25thiaz-gly-betaibph


7590: tolhs-ithiadiaz-gly-betambiph


7591: bhs-triaz-leu-betadcph


7592: tolhs-25oxaz-gly-betaphethio


7593:tolhs-24thioph-bala-betahdcph


7594: tolhs-25oxaz-gly-betafluo


7595: bhs-me25oxaz-ala-beta34meoph


7596: bhs-24thioph-bala-zdap


7597: ibhs-oxadiaz-gly-betaipr


7598:tolhs-25methiaz-bala-betahdbph


7599: bhs-me25thioph-leu-zdap


7600: tolhs-24thiaz-gly-betadmoph


7601: phhs-25thiaz-gly-betaftrif


7602: tolhs-25methiaz-gly-betahmofu


7603:bhs-oxadiaz-bala-betaphethioa


7604: phhs-25thiaz-bala-betadmph


7605: phhs-24thiaz-gly-betapych


7606: bhs-me24thiaz-gly-beta34meoph


7607: bhs-24thioph-gly-betahni


7608:bhs-25thiaz-gly-betadcphch


7609: tolhs-oxadiaz-bala-betamethi


7610: ibhs-25methiaz-gly-betameph


7611: phhs-25oxaz-gly-beta4bph


7612: tolhs-24thiaz-gly-aspibua


7613:2py-24thiaz-gly-betatbuph


7614: phhs-oxadiaz-gly-betah35dc


7615: phhs-ithiadiaz-gly-betapy


7616: bhs-25oxaz-bala-betabthioph


7617: tolhs-oxadiaz-gly-betathiobe


7618:bhs-25thiaz-gly-betahdbph


7619: ibhs-25oxaz-gly-betahc


7620: 2py-35thioph-bala-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-232
7621:bim-me24thiaz-leu-beta34meoph


7622:tolhs-24thiaz-bala-betafphe


7623:2py-26py-phg-zdap


7624:bhs-24thioph-gly-beta34meoph


7625:tolhs-oxadiaz-bala-betamethioph


7626:phhs-nme35pyr-bala-betamethi


7627:bhs-ithiadiaz-ala-betahph


7628:phhs-25oxaz-gly-betafu2


7629:bhs-nme35pyr-bala-zdapch


107630:bhs-24thioph-gly-aspaba


7631:tolhs-25thiaz-gly-betadrnoph


7632:tolhs-24thioph-bala-betatos


7633:bhs-25oxaz-bala-betadito


7634:bhs-53pyrazo-leu-psdap


157635:ibhs-oxadiaz-gly-betaipro


7636:2py-12me35pyr-gly-asppha


7637:thpy-25thiaz-gly-betadcph


7638:gua-25thiaz-gly-betaftrif


7639:bim-nme35pyr-bala-zdap


207640:phhs-25thiaz-gly-betapym


7641:bim-42nmeim-ala-psdap


7642:bhs-24thioph-bala-beta35dbph


7643:tolhs-25oxaz-bala-betafph


7644:tolhs-25methiaz-gly-betaimid


257645:phhs-me25oxaz-bala-beta34meoph


7646:bim-me25thioph-leu-betapy


7647:phhs-24thiaz-gly-betaheph


7648:ibhs-25oxaz-bala-csdap


7649:tolhs-me24oxaz-leu-zdap


307650:bhs-oxadiaz-bala-betah35dc


7651:bhs-24thioph-nmgly-beta3quin


7652:tolhs-25oxaz-bala-psdaptb


7653:bhs-nme35pyr-gly-betaibph


7654:bhs-oxadiaz-bala-betafluo


357655:dimethpym-25oxaz-bala-betapy


7656:tolhs-nme35pyr-bala-betafu2


7657:phhs-nme35pyr-bala-betatbuph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-233
7658:bhs-25oxaz-bala-psdap


7659:bim-oxadiaz-gly-aspaba


7660:tolhs-ithiadiaz-gly-betabdimo


7661:bhs-24thioph-bala-betafphe


7662:tolhs-25oxaz-gly-busu2be


7663:bim-35pyrazo-ala-zdap


7664:impy-24thiaz-bala-busu2be


7665:gua-24thiaz-gly-betatrif


7666:phhs-me25oxaz-gly-betadcph


107667:phhs-me24thioph-leu-zdap


7668:phhs-24thioph-gly-betadcph


7669:tolhs-ithiadiaz-bala-betatos


7670:bhs-ithiadiaz-gly-betafphe


7671:phhs-ithiadiaz-bala-betadcphtb


157672:bhs-24thioph-bala-betahbcph


7673:bhs-ithiadiaz-gly-zdapch


7674:bim-42nmeim-ala-zdap


7675:tolhs-25methiaz-gly-betadcphtb


7676.tolhs-nme35pyr-gly-betafu3


207677:bhs-24thiaz-phg-betapy


7678:ibhs-ithiadiaz-gly-suabu


7679:dhpyrr-25oxaz-bala-betadcph


7680:ibhs-oxadiaz-gly-betapbiph


7681:ibhs-25oxaz-bala-betathiome


257682:hts-24oxaz-gly-betapy


7683:tolhs-25oxaz-gly-psdapch


7684:phhs-25methiaz-gly-betal3bendi


7685:bim-25thiaz-bala-zdap


7686:gua-42pym-gly-betahdcph


307687:phhs-25oxaz-gly-betaanaphth


7688:phhs-ithiadiaz-gly-betathio3


7689:bhs-nme35pyr-gly-beta34meoph


7690;bhs-25thiaz-gly-betafu3


7691:bim-24thiaz-ala-betapy


357692:tolhs-ithiadiaz-gly-betabpy


7693:ibhs-25thiaz-bala-beta4bph


7694:tolhs-nme35pyr-bala-betadmph




CA 02371604 2001-10-24
WOOO166618 PCTIEP00103469
-234-
7695:ibhs-24thioph-gly-betathio3


7696:bhs-24thioph-gly-betainyl


7697:ur-42nmeim-gly-psdap


7698:phhs-25oxaz-bala-betacthioph


7699:bim-24thioph-bala-aspaba


7700:bim-me24oxaz-bala-betapy


7701:ibhs-nme35pyr-bala-betadmph


7702:ibhs-24thiaz-bala-betadcph


7703:tolhs-25oxaz-gly-betabdimo


107704:bhs-nme35pyr-gly-beta23meoph


7705:bhs-nme35pyr-bala-betafu3


7706.cima-42pym-gly-betainyl


7707:tvlhs-oxadiaz-bala-betadcphtb


7708:2py-me24thioph-ala-zdap


157709:phhs-25oxaz-bala-betaet


7710:ibhs-oxadiaz-gly-betambiph


7711:bhs-ithiadiaz-bala-betaet


7712:gua-24oxaz-gly-betadcph


7713:tolhs-25methiaz-gly-betaph


207714:bhs-25thiaz-gly-betacph


7715:impy-25oxaz-bala-betaoxaz


7716:ibhs-oxadiaz-bala-beta35dbph


7717:phhs-ithiadiaz-bala-beta34meoph


7718:2py-35thioph-gly-psdap


257719:tolhs-nme35pyr-bala-betadcphtb


7720:dhim-52thiaz-gly-betainyl


7721:bhs-25methiaz-nmgly-betathioph


7722:tolhs-24thioph-gly-betaimid


7723:bhs-25methiaz-bala-betaheph


307724:phhs-nme35pyr-bala-betahdbph


7725:phhs-25thiaz-gly-psdap


7726:bhs-ithiadiaz-gly-betadcph


7727:tolhs-nme35pyr-bala-betabpy


7728:ibhs-25thiaz-bala-psdaptb


357729:2py-25thiaz-gly-aspbzla


7730:phhs-25oxaz-gly-betabph


7731:phhs-25oxaz-gly-betamesu




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-235-
7732:bhs-oxadiaz-ala-betabnaphth


7733:bhs-nme35pyr-bala-betafbph


7734:tolhs-24thioph-bala-betadito


7735:ibhs-25thiaz-bala-psdap


7736:tolhs-25thiaz-bala-betabdimo


7737:bhs-25thiaz-gly-zdapch


7738:phhs-me25thiaz-bala-betapy


7739:phhs-24thiaz-gly-betapbiph


7740:tolhs-oxadiaz-bala-betaphethio


107741:hs-26py-gly-betapy


7742:bhs-24thioph-gly-aspibua


7743:phhs-nme35pyr-bala-betabdimo


7744:gua-24thiaz-gly-betathio3


7745:bhs-25methiaz-gly-betabpy


157746:dhim-42pym-gly-psdap


7747:ibhs-25thiaz-gly-asppha


7748:tolhs-nme35pyr-gly-betathiobe


7749:2py-me24oxaz-leu-psdap


7750:phhs-25thiaz-bala-zdaptb


207751:2py-42pym-ala-betapy


7752:phhs-25methiaz-bala-betahdcph


7753:phhs-25oxaz-gly-psdapee


7754:ibhs-24thiaz-gly-betambiph


7755:phhs-oxadiaz-gly-zdap


257756:bhs-35thioph-leu-psdap


7757:tolhs-ithiadiaz-gly-betathioph


7758:bim-25fur-leu-zdap


7759:gua-24thiaz-gly-betadmph


7760:phhs-ithiadiaz-gly-betatrif


307761:gua-42pym-gly-betapy


7762:phhs-25oxaz-bala-betaol


7763:bim-oxadiaz-gly-zdap


7764:ibhs-oxadiaz-gly-betainyl


7765:bhs-25methiaz-bala-betadbph


357766:phhs-24thiaz-gly-betabdimo


7767:bhs-25thiaz-nmgly-beta23meoph


7768:bhs-25thiaz-gly-betathiome




CA 02371604 2001-10-24
W000166618 PCTIEP00I03469
-236-
7769:tolhs-me25thiaz-ala-betadcph


7770:bhs-me25oxaz-bala-psdap


7771:bhs-nme35pyr-bala-betadbph


7772:bhs-25methiaz-gly-betathioph


7773:bhs-24thioph-nmgly-beta34dcph


7774:ibhs-25methiaz-bala-betadmoph


7775:phhs-24thioph-bala-betaheph


7776:bhs-25oxaz-bala-betabph


7777:bhs-oxadiaz-ala-betahmph


107778:phhs-nme35pyr-bala-betaimid


7779:ibhs-oxadiaz-bala-betapym


7780:ibhs-25thiaz-gly-betafphe


7781:2py-24thiaz-gly-psdap


7782:tolhs-24thiaz-gly-betathiome


157783:bhs-ithiadiaz-nmgly-betaoxaz


7784:thazep-24oxaz-gly-betapy


7785:phhs-oxadiaz-bala-psdap


7786:ibhs-25oxaz-gly-beta4bph


7787:phhs-25thiaz-gly-betapyee


207788:bhs-35thioph-gly-betapy


7789:2py-35fur-1 eu-psdap


7790:tolhs-24thioph-gly-aspibua


7791:tolhs-24thioph-bala-betaftrif


7792:bhs-25methiaz-gly-betahc


257793:tolhs-24thiaz-gly-psdapee


7794:bim-24thiaz-gly-betapy


7795:tolhs-25thiaz-bala-betaibph


7796:tolhs-me24thiaz-leu-betadcph


7797:2py-me24oxaz-bala-beta34meoph


307798:bhs-nme35pyr-nmgly-beta13bendi


7799:phhs-25oxaz-gly-betafphe


7800:bhs-nme35pyr-bala-betahph


7801.impy-25thiaz-gly-zdap


7802:gua-24oxaz-giy-betafluo


357803:phhs-ithiadiaz-gly-betaheph


7804.bhs-42nmeim-leu-betadcph


7805:phhs-nme35pyr-bala-busu2be




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-237
7806: bim-thiadiaz-leu-psdap


7807: dhim-52thiaz-ala-zdap


7808: bhs-24thioph-gly-betahdbph


7809: nmhs-24oxaz-gly-betapy


7810: gua-42pym-gly-betahb


7811: tolhs-ithiadiaz-gly-betathiome


7812: 2py-24thioph-bala-aspbzla


7813: bhs-25oxaz-gly-betathiobe


7814: tolhs-me24oxaz-bala-psdap


7815:bhs-24thioph-gly-betahmph


7816: tolhs-nme35pyr-bala-csdap


7817: ibhs-25thiaz-giy-betamesu


7818: phhs-24thiaz-bala-ibsdap


7819: 2py-thiadiaz-gly-betadcph


7820:2py-42oxaz-ala-betapy


7821: bhs-25thiaz-gly-psdapee


7822: bim-oxadiaz-ala-betadcph


7823: phhs-24thioph-bala-betadcphtb


7824: tolhs-25thiaz-gly-betampy


7825:ibhs-24thiaz-gly-betapych


7826: phhs-24thioph-gly-betamesu


7827: tolhs-me25thiaz-bala-psdap


7828: bim-25oxaz-bala-betadcph


7829: bhs-nme35pyr-gly-zdapch


7830:ibhs-25methiaz-gly-betaphethioa


7831: phhs-24thiaz-bala-aspaba


7832: tolhs-24thioph-bala-betahdbph


7833: bhs-me24thioph-leu-psdap


7834: phhs-25oxaz-gly-betathio3


7835:bhs-24thiaz-bala-beta4bph


7836: phhs-nme35pyr-gly-betatos


7837: ibhs-nme35pyr-bala-betaoxaz


7838: tolhs-24thioph-bala-betahbcph


7839: bhs-oxadiaz-gly-betahni


7840:phhs-25oxaz-bala-betaphethioa


7841: 2py-24thioph-bala-asppha


7842: tolhs-24thioph-gly-betaomebendi




CA 02371604 2001-10-24
W000166698 PCTlEP00103469
-238-
7843: tolhs-25oxaz-bala-betabediox


7844: impy-24thioph-bala-betamesu


7845: ibhs-24thiaz-bala-betathiome


7846: 2py-4.2nmeim-ala-betapy


7847: ibhs-24thiaz-bala-betaphethio


7848: phhs-24thioph-bala-betafbph


7849: phhs-me25thioph-ala-psdap


7850: bhs-nme35pyr-gly-betamethi


7851: bim-me25thivph-bala-beta34meoph


107852: bhs-24thioph-gly-betapyr


7853: ibhs-oxadiaz-gly-betaoxaz


7854: bhs-me24thioph-gly-betaph


7855: bhs-53pyrazo-ala-psdap


7856: phhs-oxadiaz-bala-betabdimo


157857: bhs-24thiaz-gly-betadtrif


7858: bim-25oxaz-leu-betadcph


7859: ibhs-ithiadiaz-gly-betapym


7860: bhs-nme35pyr-bala-beta3quin


7861: bhs-ithiadiaz-bala-betabdimo


207862: ibhs-oxadiaz-bala-betahmph


7863: tolhs-25methiaz-gly-betahmo


7864: ibhs-25methiaz-gly-betamethi


7865: ibhs-25thiaz-gly-aspaba


7866: bhs-oxadiaz-bala-betadcphch


257867: ibhs-ithiadiaz-bala-betapych


7868: bhs-24thiaz-gly-betabmph


7869: ibhs-ithiadiaz-gly-csdap


7870: bhs-25oxaz-ala-betameph


7871: bhs-25oxaz-gly-psdapch


307872: bhs-25thiaz-bala-beta35dbph


7873: bim-nme35pyr-bala-betadcph


7874: phhs-oxadiaz-bala-betadcph


7875: bim-24oxaz-leu-zdap


7876: bhs-ithiadiaz-gly-betaphethioa


357877: bhs-24thiaz-gly-betatho3


7878: tolhs-24thiaz-bala-betampy


7879: bhs-24thiaz-gly-betadito




CA 02371604 2001-10-24
W000166618 PCTlEP00/03469
-239
7880: bhs-me24thioph-bala-betaph


7881: 2py-24oxaz-ala-betainyl


7882: bhs-nme35pyr-bala-betabthioph


7883: phhs-25methiaz-bala-betathio3


7884: bhs-25thiaz-gly-betabph


7885: tolhs-25thiaz-gly-betadcph


7886: ibhs-24thioph-gly-betaimid


7887: ibhs-24thiaz-gly-betadcph


7888: ibhs-ithiadiaz-gly-psdapch


7889:tolhs-me25thiaz-ala-betaph


7890: thazep-42pym-gly-betadcph


7891: bhs-25thiaz-bala-betaol


7892: phhs-ithiadiaz-gly-psdapee


7893: bhs-24thioph-ala-betaipro


7894:bhs-24thioph-gly-betaftrif


7895: bhs-ithiadiaz-bala-betapych


7896: phhs-24thiaz-gly-betaamibe


7897: bhs-nme35pyr-giy-betaphethioa


7898: bim-25methiaz-gly-betaanaphth


7899:bim-thiadiaz-gly-zdap


7900: ibhs-25methiaz-gly-asppha


7901: tolhs-24thiaz-bala-betaphethio


7902: ibhs-24thiaz-bala-psdapch


7903: tolhs-25thiaz-gly-betaanaphth


7904:bhs-25methiaz-bala-betadcphee


7905: tolhs-me24oxaz-bala-betadcph


7906: bhs-25methiaz-bala-psdap


7907: tolhs-nme35pyr-bala-betafph


7908: ibhs-oxadiaz-gly-zdaptb


7909:bhs-oxadiaz-ala-betabpy


7910: bhs-nme35pyr-gly-betathiome


7911: 2py-42oxaz-gly-psdap


7912: bim-me24oxaz-gly-betapy


7913: tolhs-25oxaz-bala-betahb


7914:ibhs-ithiadiaz-gly-betah35dc


7915: phhs-25methiaz-bala-betapym


7916: bhs-ithiadiaz-gly-busu2be




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-240-
7917:tolhs-ithiadiaz-bala-betacph


7918:tolhs-24thioph-bala-zdapee


7919:bhs-me25thiaz-leu-psdap


7920:gua-24thiaz-gly-betabnaphth


7921:bhs-oxadiaz-gly-betaipr


7922:bhs-me25thiaz-bala-beta34meoph


7923:bhs-25thiaz-bala-betamethioph


7924:tolhs-24thiaz-bala-betadito


7925:ibhs-ithiadiaz-bala-betacbph


7926:phhs-24thiaz-gly-betafbph


7927:phhs-24thioph-gly-betacph


7928:phhs-25methiaz-bala-betainyl


7929:ibhs-nme35pyr-gly-betabthioph


7930:tolhs-24thiaz-bala-betahph


7931:tolhs-25oxaz-gly-betahcbph


7932:tolhs-me24oxaz-bala-beta34meoph


7933:tolhs-me25oxaz-leu-betaph


7934:bhs-nme35pyr-gly-betafu2


7935:bhs-me25oxaz-gly-beta34meoph


7936:tolhs-25thiaz-bala-betapyee


7937:ibhs-nme35pyr-bala-betaanaphth


7938:bhs-oxadiaz-ala-betathio3


7939:2py-25fur-ala-betapy


7940:tolhs-25oxaz-bala-csdap


7941:tolhs-nme35pyr-bala-aspibua


7942:4pmhs-25methiaz-bala-betameph


7943:bhs-nme35pyr-ala-betabnaphth


7944:phhs-24thiaz-gly-betabmph


7945:tolhs-24thiaz-gly-betaoxaz


7946:ibhs-ithiadiaz-bala-betambiph


7947:impy-25methiaz-bala-betah35dc


7948:tolhs-25oxaz-gly-betaet


7949:phhs-oxadiaz-bafa-betampy


7950:phhs-ithiadiaz-gly-betambiph


7951:bhs-nme35pyr-gly-betapytb


7952:phhs-ithiadiaz-bala-betabpy


7953:bim-25thioph-leu-zdap




CA 02371604 2001-10-24
WO00166618 PCTIEP00103469
-241
7954:bhs-24thiaz-ala-betafphe


7955:ibhs-nme35pyr-bala-betafu2


7956:bhs-24thiaz-bala-zdapee


7957:phhs-24thiaz-bala-betacthioph


7958:bim-53pyrazo-leu-zdap


7959:ibhs-24thiaz-bala-zdapee


7960:bim-me25thioph-gly-zdap


7961:ibhs-oxadiaz-bala-betacthioph


7962:tolhs-me25thioph-bala-psdap


7963:phhs-25thiaz-gly-betafu3


7964:ibhs-24thiaz-bala-betabenfu


7965:tolhs-25thiaz-gly-betacbph


7966:bhs-24thiaz-gly-betafbph


7967:bim-35fur-leu-betadcph


7968:bim-25oxaz-bala-betahph


7969:phhs-24thiaz-gly-beta34dcph


7970:ibhs-nme35pyr-gly-beta23meoph


7971:phhs-24thiaz-bala-betamethioph


7972:ibhs-25thiaz-gly-beta3quin


7973:bim-25thioph-leu-psdap


7974:bhs-25thiaz-gly-psdaptb


7975:bhs-ithiadiaz-bala-betambiph


7976:bhs-24thiaz-bala-betabthioph


7977:bhs-24thiaz-gly-beta34meoph


7978:bhs-24thioph-bala-betambiph


7979:bhs-ithiadiaz-ala-psdap


7980:phhs-25thiaz-gly-betapych


.7981:bhs-oxadiaz-bala-betaph


7982:2py-42oxaz-bala-zdap


7983:bhs-oxadiaz-gly-betadcphch


7984:bhs-25thiaz-gly-betabmph


7985:bhs-25methiaz-gly-betafu3


7986:bhs-nme35pyr-gly-betahmofu


7987:ibhs-oxadiaz-bala-psdap


7988:2py-me24thioph-ala-beta34meoph


7989:2py-nme35pyr-bala-betadcph


7990:phhs-24thioph-bala-betathio3




CA 02371604 2001-10-24
VIIOOOl66618 PCTIEP00103469
-242
7991: 2py-35th ioph-ala-betadcph


7992: phhs-24thioph-gly-betahcbph


7993: 2py-35fur-leu-betadcph


7994: ibhs-oxadiaz-bala-betadmph


7995. bhs-nme35pyr-gly-betaph


7996: ibhs-oxadiaz-bala-betapytb


7997: phhs-25thiaz-gly-zdap


7998: impy-25oxaz-gly-betahdbph


7999: bhs-me25oxaz-bala-betadcph


8000:bim-25fur-gly-zdap


8001: bhs-25oxaz-ala-betaipro


8002: bhs-24thioph-nmgly-betahmph


8003: tolhs-nme35pyr-gly-betamethi


8004: bhs-me25thiaz-ala-psdap


8005:gua-24thiaz-gly-betaphethioa


8006: bim-25methiaz-leu-betadcph


8007: ibhs-ithiadiaz-bala-csdap


8008: phhs-25oxaz-gly-aspaba


8009: tolhs-oxadiaz-gly-betathiome


8010:phhs-24thioph-gly-psdapee


8011: phhs-nme35pyr-gly-psdap


8012; bhs-25oxaz-nmgly-betameph


8013: tolhs-oxadiaz-gly-beta23meoph


8014: ibhs-24thiaz-bala-betathioph


8015:tolhs-24thiaz-gly-betaet


8016: bhs-25oxaz-ala-betacthioph


8017: tolhs-oxadiaz-gly-betahmofu


8018: phhs-24thioph-gly-betaet


8019: ibhs-25thiaz-bala-betabph


8020:tolhs-24thioph-bala-betampy


8021: bhs-25oxaz-gly-betahni


8022: bhs-25oxaz-gly-betahmofu


8023: bhs-me25thiaz-ala-betadcph


8024: pbhs-24thioph-bala-beta35dbph


8025:dhim-42pym-ala-psdap


8026: 2py-24thioph-gly-betatbuph


8027: bhs-oxadiaz-ala-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-243
8028: 2py-35thioph-leu-zdap


8029: phhs-oxadiaz-gly-betaimid


8030: phhs-nme35pyr-gly-betacph


8031: ibhs-nme35pyr-bala-zdap


8032: gua-26py-gly-betadmph


8033: phhs-25thiaz-gly-betaoxope


8034: ibhs-oxadiaz-gly-betaamibe


8035: phhs-24thioph-gly-betapyee


8036: 2py-35thioph-gly-betapy


8037:bhs-35fur-ala-betapy


8038: bhs-24thiaz-nmgly-betamesu


8039: phhs-nme35pyr-gly-betaanaphth


8040: bgua-42pym-gly-betainyl


8041: ibhs-24thiaz-bala-betafphe


8042:bhs-25thiaz-ala-betathio3


8043: tolhs-24thiaz-bala-betacthioph


8044: bhs-25fur-leu-betapy


8045: phhs-24thiaz-gly-betafu3


8046: phhs-24thiaz-gly-betahdcph


8047:tolhs-25thiaz-gly-aspibua


8048: phhs-25oxaz-bala-betapyee


8049: ibhs-oxadiaz-gly-aspaba


8050: phhs-25methiaz-bala-betafbph


8051: bhs-25oxaz-nmgly-betadito


8052:bhs-oxadiaz-bala-betapyee


8053: agua-25oxaz-bala-betameph


8054: bim-me25thioph-bala-betadcph


8055: tolhs-24thiaz-bala-betahb


8056: tolhs-me24thiaz-gly-psdap


8057:bhs-24thiaz-bala-betaphethioa


8058: 2py-25thiaz-leu-zdap


8059: ibhs-oxadiaz-gly-betah35dc


8060: tolhs-24thiaz-gly-beta4bph


8061: bhs-25methiaz-gly-betaipr


8062:tolhs-ithiadiaz-gly-betaibph


8063: dhim-23thioph-gly-betameph


8064: bhs-24thioph-bala-zdaptb




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-244
8065:ibhs-25oxaz-gly-betaibph


8066:bhs-oxadiaz-nmgly-betacthioph


8067:bim-me25thioph-gly-betapy


8068:bhs-24thioph-gly-betahbcph


8069:bim-me24oxaz-gly-betaph


8070:impy-25oxaz-bala-betahmo


8071:ibhs-25methiaz-gly-beta23meoph


8072:2py-ithiadiaz-bala-psdap


8073:phhs-24thiaz-gly-betatos


8074:bim-me24oxaz-leu-betaph


8075:2py-26py-gly-psdap


8076:bhs-24thiaz-ala-betathio3


8077:bhs-25thiaz-bala-betatrif


8078:bim-24thiaz-gly-aspibua


8079:phhs-oxadiaz-bala-betathiome


8080:tolhs-24thioph-gly-betaibph


8081:phhs-24thiaz-bala-betaphethio


8082:tolhs-ithiadiaz-bala-betaph


8083:bhs-24thiaz-bala-betathiome


8084:bhs-me25thioph-gly-zdap


8085:phhs-nme35pyr-gly-betathiome


8086:tolhs-ithiadiaz-gly-zdapee


8087:phhs-25oxaz-bala-betaamibe


8088:bim-24oxaz-bala-psdap


8089:phhs-25oxaz-bala-aspbzla


8090:bim-42oxaz-gly-zdap


8092:ibhs-25thiaz-bala-betatos


8092:ibhs-oxadiaz-bala-aspaba


8093:phhs-nme35pyr-gly-betadcph


8094:gua-24thiaz-gly-beta3quin


8095:2py-25oxaz-gly-betathiobe


8096:tolhs-25methiaz-bala-betabnaphth


8097:bhs-25oxaz-ala-betacph


8098:bhs-nme35pyr-bala-betahcbph


8099:bim-me24thioph-ala-betaph


8100:ibhs-25methiaz-bala-ibsdap


8101:bhs-25methiaz-leu-zdap




CA 02371604 2001-10-24
W400166618 PCTIEP00103469
-245
8102:bhs-25thiaz-ala-betadhbfu


8103:bim-42oxaz-gly-psdap


8104:bhs-25thiaz-gly-betabiph


8105:gua-25thioph-gly-betaipr


8106:phhs-24thioph-gly-betapych


8107:bhs-25oxaz-gly-beta23meoph


8108:tolhs-24thioph-bala-asppha


8109:bhs-24thiaz-gly-betaipro


8110:tolhs-ithiadiaz-bala-betahdcph


8111:bim-24thiaz-ala-zdap


8112:tolhs-25thiaz-bala-beta34meoph


8113:bhs-ithiadiaz-gly-betaipro


8114:tolhs-25thiaz-gly-betapych


8115:tolhs-24thioph-bala-aspibua


8116:bhs-nme35pyr-gly-betafbph


8117:dhim-52thiaz-ala-betadcph


8118:2py-35fur-ala-betadcph


8119:phhs-25thiaz-bala-zdap


8120:2pmhs-25thiaz-gly-betahbcph


8121:bhs-25thiaz-bala-betahph


8122:bhs-oxadiaz-bala-betathiobe


8123:bhs-25methiaz-ala-betathioph


8124:tolhs-25oxaz-gly-aspaba


8125:2py-24thiaz-g ly-beta35d
bph


8126:ibhs-ithiadiaz-gly-betahc


8127:bhs-oxadiaz-bala-betabdimo


8128.phhs-25oxaz-bala-betaphethio


8129:bhs-25oxaz-ala-beta13bendi


8130:phhs-ithiadiaz-bala-beta23meoph


8131:bhs-25methiaz-gly-betafph


8132:tolhs-24thiaz-gly-betaol


8133:tolhs-oxadiaz-gly-betaipro


8134:tolhs-25methiaz-gly-aspbzla


8135:ibhs-oxadiaz-gly-betaanaphth


8136:tolhs-oxadiaz-bala-betaoxope


8137:bhs-25methiaz-nmgly-betacthioph


8138:2pmhs-25thiaz-gly-betaph




CA 02371604 2001-10-24
W000166618 PCTlEP00l03469
-246
8139:bhs-25oxaz-gly-betadcphch


8140:bim-25oxaz-bala-betabmph


8141:bhs-nme35pyr-gly-betafphe


8142:bhs-ithiadiaz-bala-betatos


8143:phhs-24thiaz-gly-betamethi


8144:thpym-24oxaz-gly-zdap


8145:tolhs-me25thiaz-bala-beta34meoph


8146:tolhs-nme35pyr-bala-betaimid


8147:bhs-nme35pyr-ala-betainyl


8148:bhs-25oxaz-gly-betatbuph


8149:2py-42pym-ala-betadcph


8150:tolhs-24thioph-gly-betafph


8151:bim-me25oxaz-bala-betapy


8152:bim-25methiaz-bala-aspbzla


8153:2py-me25thiaz-ala-zdap


8154:tolhs-25thiaz-gly-psdaptb


8155:2py-52thiaz-ala-betadcph


8156:bhs-25oxaz-bala-betah35dc


8157:gua-24oxaz-gly-betaipro


8158:tolhs-me25thioph-ala-psdap


8159:gua-24thiaz-gly-betamethi


8160:bhs-nme35pyr-leu-betadcph


8161:bim-oxadiaz-gly-betapy


8162:bhs-35fur-ala-psdap


8163:bhs-25methiaz-gly-betapy


8164:ibhs-24thiaz-bala-beta13bendi


8165:tolhs-24thiaz-bala-beta3quin


8166:bhs-ithiadiaz-bala-betatrif


8167:bhs-ithiadiaz-gly-betahmph


8168:tolhs-ithiadiaz-gly-betaheph


8169:tolhs-24thioph-gly-betampy


8170:tolhs-25oxaz-gly-betathiome


8171:ibhs-nme35pyr-gly-betahdcph


8172:ibhs-oxadiaz-bala-betabediox


8173:phhs-25methiaz-bala-betadhbfu


8174:bhs-25methiaz-gly-betabnaphth


8175:bhs-ithiadiaz-bala-betacph




CA 02371604 2001-10-24
W000166618 PCTIEP00103469
-247
8176:bhs-24thioph-bala-betadmph


8177:tolhs-nme35pyr-bala-betafu3


8178:phhs-25methiaz-gly-betahni


8179:ibhs-25methiaz-bala-betaphethioa


8180:tolhs-nme35pyr-bala-betamethioph


8181:tolhs-ithiadiaz-bala-betaphethio


8182:tolhs-25methiaz-gly-betaipro


8183:ibhs-24thiaz-gly-betaanaphth


8184:bhs-nme35pyr-bala-betabediox


8185:2pmhs-42nmeim-bala-betapym


8186:ibhs-25oxaz-gly-betaipro


8187:phhs-24thioph-gly-psdap


8188:bhs-25oxaz-nmgly-betathio3


8189:bhs-24thioph-bala-betadtrif


8190:tolhs-ithiadiaz-bala-betamethi


8191:tolhs-25methiaz-bala-betabenfu


8192:ibhs-24thioph-bala-betadmoph


8193:tolhs-25oxaz-gly-betahb


8194:tolhs-me24thiaz-gly-zdap


8195:phhs-oxadiaz-gly-betathioph


8196:bhs-25thiaz-gly-betafphe


8197:ibhs-24thioph-bala-betaipr


8198:gua-25thioph-gly-betapyr


8199:phhs-nme35pyr-gly-betameph


8200:ibhs-25oxaz-gly-zdap


8201:ibhs-25methiaz-gly-zdap


8202:bhs-24thiaz-ala-betainyl


8203:bhs-nme35pyr-bala-betathiome


8204:bhs-24thiaz-bala-betathiobe


8205:tolhs-24thiaz-bala-betapym


8206:tolhs-25methiaz-gly-betathioph


8207:tolhs-ithiadiaz-bala-betapym


8208:tolhs-25oxaz-bala-betaimid


8209:tolhs-ithiadiaz-bala-betaipro


8210:bhs-25thiaz-bala-beta13bendi


8211:2pmhs-24thioph-gly-betabpy


8212:ibhs-ithiadiaz-bala-betadcph




CA 02371604 2001-10-24
W000166618 PCTIEPOOI03469
-248
8213: bhs-24thiaz-gly-betabnaphth


8214: bhs-25oxaz-bala-betahmno


8215: 2py-me24oxaz-leu-betaph


8216: tolhs-25methiaz-gly-betahph


8217: phhs-25oxaz-gly-betapyr


8218: bhs-25oxaz-nmgly-betafphe


8219: bim-25thiaz-gly-betameph


8220: bhs-oxadiaz-bala-aspbzla


8221: bim-25oxaz-gly-betahb


108222: phhs-me25thiaz-ala-zdap


8223: tolhs-me24oxaz-bala-betapy


8224: gua-24thiaz-gly-betahbcph


8225: bim-24oxaz-ala-betainyl


8226: 2pmhs-25oxaz-gly-betathio3


158227: bhs-25oxaz-bala-betadcphtb


8228: 2py-me24oxaz-gly-betaph


8229: bhs-24thiaz-nmgly-beta34dcph


8230: ibhs-nme35pyr-bala-beta13bendi


8231: bhs-me24thiaz-gly-psdap


208232: ibhs-nme35pyr-bala-betadtrif


8233: tolhs-nme35pyr-bala-betaoxope


8234: 2py-25fur-leu-betapy


8235: tolhs-nme35pyr-bala-betahc


8236: 2py-me24thiaz-ala-psdap


258237: bim-me24thiaz-ala-betapy


8238: tolhs-25thiaz-gly-betabthioph


8239: 2py-25thioph-bala-psdap


8240: ibhs-25thiaz-gly-betahdcph


8241: bim-26py-gly-psdap


308242: 2py-35fur-gly-betapy


8243: phhs-25methiaz-bala-betabph


8244: phhs-25thiaz-bala-betahbcph


8245: ibhs-24thioph-gly-betadcphtb


8246: 2py-me25thiaz-leu-betaph


358247: ibhs-25thiaz-gly-betaipr


8248: ibhs-24thioph-gly-betacbph


8249: ibhs-25methiaz-bala-betaamibe






DEMANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVETS
COMPRI~:ND PLUS D'UN TOME.
CECI EST L,E TOME 1 DE 2
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des
Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
THIS IS VOLUME 1 OF 2
NOTE: For additional valumes please contact the Canadian Patent Office.