ONGUENT POUR DESINFECTER LA PEAU

SKIN DISINFECTION OINTMENT

Abrégé anglais

ABSTRACT OF THE DISCLOSURE
A skin ointment consists of a stable disinfectant
gel having a creamy consistency comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine 0.2 to 2.0 %
cetyl alcohol 0.3 to 0.4 %
isopropyl myrisate 0.3 to 0.4 %
Water to make 100 %
The carboxy vinyl polymer and the basic amine react to form a
salt of the carboxy vinyl polymer sufficient to impart a gel-
like consistency to the ointment without interfering with its
disinfectant activity.

Revendications

The embodiments of the invention in which an exclusive
property or privilege is claimed are defined as follows:
1. A skin ointment consisting of a stable disinfectant
gel having a creamy consistency comprising by weight:
ethanol 45 to 95%
glycerine 0.2 to 5.0%
carboxy vinyl polymer 0.2 to 2.0%
a basic amine 0.2 to 2.0%
cetyl alcohol 0.3 to 0.4%
isopropyl myrisate 0.3 to 0.4%
water to make 100%
said carboxy vinyl polymer and said basic amine reacting to
form a salt of said carboxy vinyl polymer sufficient to im-
part a gel-like consistency to said ointment without inter-
fering with the disinfectant activity of the ointment.
2. An ointment according to claim 1, wherein said
salt forming amine is selected from the group consisting of
triethanol amine, di(2-ethylhexyl) amine, triethylamine and
diisopropanolamine.
3. An ointment according to claim 1, wherein said amine
is triethanolamine.

Description

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The present invention relates to a skin disinfection
ointment containing alcohol as its disinfectan-t.
With prior art ointments of the type mentioned in the
opening paragraph, it is difficult to attain a high disinfective
power while maintaining the necessary creamy consistency. As a
matter of fact, the ointment can obtain a high disinfective power
by imparting to it a high alcohol content, but on the other hand
the ointment will more and more lose its creamy consistency, the
more its alcohol content, and thus its disinfective power is
0 increased.
The present invention has for its object to provide an
ointment which has a high disinfective power and, in addition,
has a creamy consistency so that it is conveniently applicable.
The ointment, in addition, will be easily available because it
may be kept up, for instance, in a collapsible tube to put in a
pocket and, thus may substitute a handwash in cases where the
handwash would have been undertaken solely for disinfection pur-
poses, whereby the tendency of the hands to dry out will be reduced.
According to the present invention, a skin ointment
consists of a stable disinfectant gel having a creamy consistency
comprising by weight:
ethanol 45 to 95 %
glycerine 0.2 to 5.0 %
carboxy vinyl polymer 0.2 to 2.0 %
a basic amine0 2 to 2.0 %
cetyl alcohol0.3 to 0.4 %
isopropyl myrisate0.3 to 0.4 %
water to make 100 %
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The carboxy vinyl polymer and the basic amine react to form a
salt of the carboxy vinyl polymer sufficient to impart a gel-like
consistency to the ointment without interfering with its dis-
infectant activity.
The salt forming amine may be selected from the group
consisting of triethanol amine, di(2-ethylhexyl) amine, tri-
ethylamine and diisopropanolamine.
The ointment may further comprise cetyl alcohol in an
amount effective to reduce drying of the skin and isopropyl
myrisate in an amount effective to soften the skin. The ointment
may comprise from about 0.3 to about 0.4% cetyl alcohol and from
about 0.3 to about 0.4% isopropyl myrisate.
To cause prolongation of the time of activity, bacteri-
cidic agents may be added. Examples of such agents are, i.a.
chlorohexidine, Irgasan DP 300, hexa-chlorophen, n-dodecyl
guanidine and cetyl-pyridinium chloride.
To illustrate the possible composition of an ointment
according to the invention, the following examples are given:
Example 1
Cetyl alcohol (0.4%), isopropyl myrisate (0.4%),
glycerine (0.6%) and triethanolamine (0.5%) are admixed into 95
percentage ethanol (38.3%) until a clear solution is obtained
(Solution A).
Water (32.95%), ethanol (26.5%) and carboxy vinyl
polymer are mixed until a homogeneous solution is obtained
(Solution B).
Solution A is added to Solution B while s-tirring,
until a clear gel has formed.
* Trade Mark
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Example 2
Cetyl alcohol (0.3%), isopropyl myristate (0.3%),
glycerine (0.4%) and triethylamine (0.12%) are mixed into 95
percentage ethanol (26.4%) until a clear solution will result
(Solution A).
Water (26.7%), ethanol (45.4~) and carboxy vinyl
polymer (0.38~) are mixed until a hornogeneous solution is obtained
(Solution B).
Solution A is added to So]Lution B while stirring, until
a clear gel has formed. The ointments according to Examples 1 and
2 are very well adapted to be smeared on the skin and give an
agreeable feel of smoothness after evaporation of the ethanol.
One condition for the use of ointments of this type is
that the disinfectant power of the alcohol will not diminish or
disappear. In order to investigate this, the following bacterio-
logical ev~luation was made:
Thus, when mixing the ingredients, a basic material may
be added as a final mixing step. Owing to this step, the mixture
will rest very fluid as far as the last phase, whereas acid of
carboxy vinyl polymer as contained in the mixture will, in the
last phase, be converted by the basic compound, for instance tri-
ethanolamine, di(2-ethylhexyl)amine, triethylamine or diiso-
propanolamine, into a salt of the carboxy vinyl polymer,
accompanied by a very substantial thickening of the mixture.
Thus, this mixing method is advantageous, however it
is possible to "dissolve" the acid of carboxy vinyl polymer
separately, for instance in 70 percentage alcohol, and for example
triethanolamine and the remaining ingredients separately, for
A
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instance in 95 percentage alcohol, a~ter which the separate
mixtures are combined as a final mixing step, whereby the sub-
stantial thickening of the mixture is obtained
The resulting compositiOn had a smooth, creamy con-
sistency.
A method of testing spirit cream:
Cultivation of bacteria is performed in the same way
as in performing disinfection tests according to Kjellander, where
the last step comprises a centrifugation of cultivated bacteria,
followed by sludging in inactivated horse blood. The inoculate
should be about 107 to 108, and possible correction in the sludge
for any gram-bacteria-killing on application.
l. Hands to be washed carefully before commencing the
test run, and treat with spirit. Let dry.
2. Apply 0~2 ml. in the palm of the hand, rub in during
5 secs. with left forefinger. Let dry about 5 to lO min.
3. Apply 2 ml. spirit or spirit cream. Rub for 30 secs.
to cover the hand completely. Let dry in air for about 2 min.
4. Wash hands 5 min, in a small metal bowl containing
250 ml. Leetheen-bouillon.
5. Take 0.1 ml. from the washing bowl and 0.1 ml. from
dilution 10 l and spread out with a scraper on a Leetheen-agar
slide. Cultivate for 48 hours at 35C.
For O-test exclude Point 3.
The tests are carried out on 5 test persons 3 times,
at least 24 hrs. between applications.
For O-test, i.e. non-treated test, 1 series of 5 persons.
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Other examples of the invention will be clearly
apparent to a person skilled in the art, the scope of the
invention being defined in the appended claims.
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