COMPOSITIONS ORALES A BASE DE SEL DE ZINC PERMETTANT DE CONTROLER LES ODEURS BUCCO-RESPIRATOIRES

ORAL COMPOSITIONS FOR CONTROLLING MOUTH AND BREATH ODORS CONTAINING A ZINC SALT

Abrégé français

L'invention concerne des compositions orales qui comprennent au moins un solvant, un tensioactif, et un composé à base de zinc du type chlorure de zinc.

Abrégé anglais

Oral compositions according to the present invention include at least one
solvent, a surfactant, and a zinc compound, such as zinc chloride.

Revendications

What is claimed is:
1. An oral composition for controlling odors comprising:
a zinc salt, a physiologically acceptable solvent and a physiologically
acceptable surface active agent.
2. An oral composition as in claim 1, wherein said zinc salt is zinc chloride.
3. An oral composition as in claim 1, wherein said solvent is selected from
the
group consisting of water, alcohol, glycerin and mixtures thereof.
4. An oral composition as in claim 1, wherein said solvent is selected from
the
group consisting of sorbitol, polyethylene glycol and mixtures thereof.
5. An oral composition as in claim 1, wherein said surface active agent is
sodium lauryl sulfate.
6. An oral composition as in claim 1, further comprising an abrasive
component.
7. A breath-freshening oral composition in the form of a toothpaste
comprising:
from about 35 to about 40 percent by weight of sorbitol; from about 23 to
about 27 percent by weight of a thickener; about 20 percent by weight of
glycerin; about 8 to about 12 percent by weight of water; about 3 percent by
weight of polyethylene glycol; about 12 percent by weight of sodium lauryl
sulfate; about 1 percent by weight of zinc chloride; each component based
upon 100 percent by weight of the total composition.
8. A breath-freshening oral rinse comprising:
About 85 to about 90 percent by weight of water; about 11 percent by weight
of ethanol; about 0.4 to about 0.44 percent by weight of a polyoxyethylene
fatty acid ester surfactant; 0.4 to about 0.44 percent by weight of Pluruonic
surfactant; and about 0.15 percent by weight of zinc chloride; each
component based upon 100 percent by weight of the total composition.
6

Description

CA 02371918 2001-11-22
WO 00/71090 PCT/US00/14100
ORAL COMPOSITIONS FOR CONTROLLING MOUTH AND BREATH ODORS CONTAINING A ZINC
SALT
BACKGROUND OF THE INVENTION
The present invention relates to oral compositions for the control of volatile
compounds associated with oral malodor.
"Oral composition" means a composition for topical applications to the oral
cavity to clean and care for the teeth as well as the oral cavity surfaces.
Representatives of such compositions are oral hygiene products and dentifrices
such
as mouthwashes or rinses, toothpaste, dental gels, tooth powder. chewing gum,
lozenges, and similar products. In addition to cleaning teeth to remove dental
plaque,
the function of oral hygiene preparations is to stop the formation of dental
calculus, to
prevent dental disorders such as caries, periodontitis and gingivitis, and
also to
eliminate halitosis.
Dental plaque is a deposit which forms on teeth and consists of inorganic and
organic components derived from saliva, food and bacteria which are present in
the
oral cavity. When plaque undergoes calcification it forms dental calculus, or
tartar as
it is sometimes called. Dental calculus is largely calcium and orthophosphate
arranged in a crystal lattice called hydroxyapatite (HAP).
Oral malodor, or halitosis, is caused by the putrefactive activity of
microorganisms on appropriate substrate components of dental plaque, debris
adhering to mucous membranes and salivary cellular elements to produce
volatile
sulfur compounds. These sulfur volatiles primarily consist of hydrogen sulfide
(H,S),
methyl mercaptan (CH3SH) and traces of dimethyl sulfide (CH3)ZS. Volatile
sulfur
compounds, aromatic amines, ammonia and urea have also been shown to increase
in
the mouth of patients suffering from periodontal disease.

CA 02371918 2001-11-22
WO 00/71090 PCT/US00/14100
Methods of inhibiting volatile sulfur compounds to reduce the production of
mouth odor have included the use of dentifrices containing antimicrobials,
such as,
chlorhexidine. However, the side effects associated with chlorhexidine, such
as a
bitter taste and staining of the teeth, tongue, gums and oral mucosa,
precludes the use
of chlorhexidine in oral compositions.
The prior art also shows oral compositions containing zinc salts such as zinc
chloride, zinc iodide, zinc fluoride, zinc phenol sulfonate and the like as
antiseptic
agents, and correctives of oral conditions such as pyorrhea. Zinc chloride has
commonly been used in oral formulations for its astringency properties. Zinc
phenol
sulfonate has been utilized in the prior art dentifrice compositions as an
anti-plaque
and anti-calculus agent as well as an odor inhibitor of fermentation and
putrefaction
which occurs in the oral cavity. Compositions in which these soluble zinc
salts have
been used have had the disadvantages such as leaving an unpleasant astringent
taste
in the mouth and/or having short-lived efficacy against plaque, and as an odor
inhibitor.
A need exists therefore for an oral composition to control mouth and breath
odors and which does no have the unpleasant taste associated with previous
oral
compositions.
DISCLOSURE OF THE INVENTION
It is therefore an object of the present invention to provide an oral
composition.
It is another object of the present invention to provide an oral composition
which controls mouth and breath odors.
It is a further object of the invention to provide oral compositions in the
nature of dentrifrices, including mouth rinses and toothpastes.
2

CA 02371918 2001-11-22
WO 00/71090 PCT/US00/14100
These and other objects of the present invention which shall become apparent
from
the specification to follow are accomplished by the invention as hereinafter
described.
In general, according to the present invention, a breath freshening toothpaste
includes at least one solvent, a surfactant, a thickener and an amount of a
zinc
compound, preferably zinc chloride.
According to another embodiment of the invention, a breath freshening rinse
includes water and alcohol or other solvents, and an amount of a zinc
component,
preferably zinc chloride.
PREFERED EMBODIMENTS FOR CARRYING OUT THE INVENTION
The present invention includes zinc components contained in an solvent.
Preferably, the zinc component is a zinc salt which includes any that are
physiologically acceptable in oral compositions. A preferred zinc salt is zinc
chloride.
The compositions according to the present invention also include a solvent
such as water, alcohol, glycerin or the like. Preferred solvents include
sorbitol,
glycerin, polyethylene glycol, water or any similar physiologically acceptable
solvent.
It is understood that certain of the solvents, such as polyethylene glycol,
can also act
as a humectant.
It is also preferred to include a surface-active agent or surfactant in the
compositions. Again, any physiologically acceptable surfactant, such as sodium
lauryl sulfate is useful in the present invention.
Other components may also be included in the compositions according to the
present invention, such as for example abrasivesn (such as Zeodent),
thickeners
(again including for example, Zeodent), emulsifiers, sweeteners, dyes and the
like,
may also be included in the present compositions.
A toothpaste according to the present invention may include the following:
3

CA 02371918 2001-11-22
WO 00/71090 PCT/US00/14100
TABLE 1
BREATH FRESHENING TOOTHPASTE
llP~f.#~~~., ~ nee o~x
p, ~~~a~~a. , n.x,.~. mss... ..~.. ..,.,>x Q >.W~.
.,: . , ,
or ito ~
eo ent a er
a v 1 1 J '11 V
eo ent (Hu er . ,
ycenn o ow 0.00 .
ater ..
~. L 1
mon ar i a . .
o ium aury a ate tep an . .
me on a Ma me o t . .
~
atraso qua on . .
avor vam a mmt (Nom a . . .
13 o mm acc ann M pec. . .
ue o. amer en nson . ,
a ow o. arner en nson . .
loo.oo
An oral rinse composition according the present invention has the following
S components.
TABLE 2
ORAL RINSE INGREDIENTS
f<,"~~< ~,; ~~.y~~,~~~~,~~;an e~'1 or'Io~w, '
' ' cv OF~I
~*~~., .'~..Lku%..,.!"47,x~M . ~.~.7 .e
~in,9~3d 2~..W l.~yysY ro, .g$~."".,r
Pk.N ~dr"-*~i
ater .
t ano arm o . .
o ysor ate . . .
uromc
me on a a er
o mm citrate a er 0.
avor mt
avor mnamic a y a
o ium acc ann a er . .
itnc ci a er - . .
ue erner en nson
100
In the above formulas, polysorbate 80 is a surfactant, namely, a
polyoxyethylene fatty acid ester. Poloximer 237 emulsifier (a polyethylene
polypropylene glycol) are useful.
4

CA 02371918 2001-11-22
WO 00/71090 PCT/US00/14100
It should be evident therefore, that the oral compositions according to the
present invention and as described above, carry out the objects of the
invention as set
forth. The present invention has been exemplified without attempting to show
all of
the variations which fall within the scope of the invention. One skilled in
the art will
readily understand how to vary the composition components, amounts, and the
like
without departing from the scope of the invention.