Note : Les descriptions sont présentées dans la langue officielle dans laquelle elles ont été soumises.
CA 02662919 2011-05-31
PHARMACEUTICAL COMPOSITIONS CONTAINING ROSUVAST ATIN CALCIUM
Field of the Investigation
The present invention relates to a novel pharmaceutical composition containing
rosuvastatin calcium as active ingredient and magnesium hydroxide and/or
calcium acetate or
calcium gluconate or calcium glycerophosphate or aluminum hydroxide as
stabilizing agent and
process for the manufacturing thereof.
Background of the investigation
It is known that the rosuvastatin {(E)-7-[4-(4-fluorophenyI)-6-isopropyl-2-
[methyl(methylsulfonypamino]pyrimidin-5-y9(3R,5S)3,5-dihydroxyhept-6-enoic
acid calcium salt)
as an active ingredient and the process for the synthesis thereof were first
described in the
patent EP 521,471.
It is also known that the marketed (under Crestor trade name) pharmaceutical
composition is described among others in the WO 01/54668, WO 01/54669 or US
Pat.
6,316,460 patent specifications. According to these descriptions manufacturing
of stable, solid
pharmaceutical composition containing rosuvastatin can not be accomplished
only by using pH
adjuvant compounds, but the presence of inorganic salts of multivalent metals
is also required
to prevent the formation of lactone and oxidation decomposition products. In
the pharmaceutical
composition inorganic salts of multivalent metals (Ca, Mg, Zn, Al, Fe and the
combinations
thereof) are used as stabilizing additives such as aluminum, magnesium
metasilicate, tribasic
calcium phosphate, tribasic magnesium phosphate and tribasic aluminum
phosphate. The
marketed (under Crestor trade name) pharmaceutical composition contains
tribasic calcium
phosphate as stabilizing agent.
There are several patent applications and specifications dealing with the
formulation
problems of HMG-CoA reductase inhibitors, namely statins, in general. It is
known from the
literature that from among HMG-CoA reductase inhibitor, lipid- lowering drugs
several
compounds are sensitive to the properties of the micro- environment of the
composition, in fact
to light, to heat and humidity. The following patent specifications describe
pharmaceutical
compositions containing statins, among others rosuvastatin.
1
CA 02662919 2011-05-31
The WO 02/089788 describes statin containing pharmaceutical compositions the
stability of which are provided by addition of amino sugars (for example N-
methyl-
glucoseamine). According to the description the advantage of the amino sugars
versus
inorganic alkali-earth metal salts is that they do not irritate the mucosa in
the intestines.
The WO 00/53173 describes delayed-release pharmaceutical compositions
containing
statins as active ingredients, in which the release of the active ingredient
in the stomach and
the lactone formation under acidic conditions are prevented by special gel
structure and
enterically coated dosage form.
= The WO 01/62230 describes a mannitol based granulate, in which the
active ingredient
statins are dissolved in NaOH solution and are added together with the
granulating solution to
the pharmaceutical dosage form.
According to the state of the art mentioned above there is a need for
producing statin -
in our case rosuvastatin - containing stable pharmaceutical compositions,
which are easy to
formulate.
Summary of the Invention
An aspect of the present invention is to develop a stable pharmaceutical
composition
containing rosuvastatin calcium, the manufacturing of which is simple and the
elaborated
compositions make possible the dose-proportional dosage of the active
ingredient.
During our experiments surprisingly it was found, that a stable pharmaceutical
composition can be produced by using magnesium hydroxide and/or calcium
acetate or calcium
gluconate or calcium glycerophosphate or aluminum hydroxide as pharmaceutical
excipients.
In addition to this the possible compositions of the pharmaceutical dosage
forms are defined
in such a way that those are suitable for the dose-proportional formulation of
the product family.
According to an aspect of the present invention there is provided a
pharmaceutical
composition comprising amorphous rosuvastatin calcium; magnesium hydroxide
and/or calcium
acetate or calcium gluconate or calcium glycerophosphate or aluminum hydroxide
as stabilizer;
and one or more pharmaceutically acceptable excipients.
According to an aspect of the present invention the pharmaceutical composition
preferably contains magnesium hydroxide and/or calcium acetate as stabilizing
additive.
2
, CA 02662919 2011-05-31
According to an aspect of the present invention the pharmaceutical composition
contains
diluent and/or binder and/or disintegrant and/or lubricant and/or film-coating
materials as
pharmaceutically acceptable excipients and in given case further excipients.
The pharmaceutical composition preferably contains lactose and/or
microcrystalline
cellulose as diluent, povidone as binder, crospovidone as disintegrant and
magnesium stearate
as lubricant.
The new pharmaceutical composition is film-coated.
According to an aspect of the present invention there is provided a process
for the
production of the pharmaceutical composition according to the present
invention, which
comprises the following steps: sieving the active ingredient and the
excipients, blending the
active ingredient, the stabilizing additive, diluent, binder, disintegrant,
adding the lubricant to the
inner phase, blending the mixture, in given case adding further excipients to
the mixture and
compressing to tablets, finally coating the tablets.
Detailed Description of Embodiments of the Invention
The invention is further illustrated by the following examples.
Examples:
Examples 1-8:
In order to prove the stability of the pharmaceutical compositions according
to our
invention the stability of rosuvastatin calcium containing dosage forms of
examples 1-8 was
examined, which were produced by the same process using different stabilizing
additives in
equal amounts.
During the stress-stability study the pharmaceutical compositions were kept at
75 C for
7 days.
3
CA 02662919 2011-05-31
Table 1.
Composition of the pharmaceutical dosage form of Examples 1-8
Components Compositions of Examples (w/w
1 _ 2 3 4 5 6 7 8
Rosuvastatin 6.93 6.93 6.93 6.93 6.93 6.93 6.93 6.93
calcium
Crospovidone 5.00 5.00 5.00 5,00 5.00 5.00 5.00 5.00
Lactose 45.00 45.00 45.00 45.00 45.00 45.00 45,00 45.00
Microcrystalline 17.00 17.00 17.00 17.00 17.00 17.00 17.00 17.00
cellulose
Magnesium 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07
stearate
Tribasic calcium 25.00 -
phosphate
(see: US
Pat.6,316,460 as
reference stabilizing
additive)
Magnesium - 25.00 -
hydroxide
Calcium acetate - - 25.00 -
Trometamol - 25.00 -
Calcium - 25.00 -
gluconate
Calcium - 25.00 -
glycerophosphate
Magnesium - 25.00 -
acetate
Aluminum - 25.00
hydroxide
The above compositions (Example 1-8) were produced the following way:
The active ingredient and the excipients were sieved, the active ingredient,
one of the
above stabilizing additives, the diluent and the disintegrant were blended.
Then the lubricant
was added to the inner phase, the mixture was blended and compressed to
tablets.
The results of the stress-stability study are summarized in Table 2.
4
CA 02662919 2011-05-31
Table 2.
The results of the stability experiments of compositions 1-8
Results at 75 C for 7 days
Example / stabilizer Total degradation Lactone product (%)
product (%)
Example 1 / tribasic calcium phosphate 0.5 0.3
Example 2 / magnesium hydroxide 0.3 0.2
Example 3 / calcium acetate 0.1 0.1
Example 4/ trometamol, >30 16.6
Example 5 / calcium gluconate 0.7 0.4
Example-6 / calcium glycerophosphate 0.2 0.1
Example 7/ magnesium acetate >30 26.0
Example 8 / aluminum hydroxide 1.2 0.5
According to the results of the stress-stability study of compositions 1-8 we
can state
that from among the examined samples degradation profile of samples containing
stabilizing
additives such as magnesium hydroxide, calcium acetate, calcium gluconate,
calcium
glycerophosphate and aluminum hydroxide was similar to the marketed product
(Crestor)
containing tribasic calcium phosphate as stabilizing additive. Therefore these
compositions are
suitable for producing stable pharmaceutical dosage forms containing amorphous
rosuvastatin
calcium.
According to the results magnesium acetate and trometamol used in equal
amounts are
not suitable for stabilizing the pharmaceutical dosage form containing
amorphous rosuvastatin
calcium.
The following examples describe the corpus composition and production of the
dose-
proportional product family (5 mg, 10 mg, 20 mg and 40 mg activity):
Example 9
Corpus composition Ratio (w/w%) in the composition
Rosuvastatin calcium 6.93
Lactose 58.00
Microcrystalline cellulose 28.74
Magnesium hydroxide 5.00
Crospovidone 0.33
Magnesium stearate 1.00
5
CA 02662919 2011-05-31
Example 10
Corpus composition Ratio (w/w%) in the composition
6.93
Rosuvastatin calcium
55.00
Lactose
27.07
Microcrystalline cellulose
5.00
Calcium acetate
5.00
Crospovidone
Magnesium stearate 1.00
Example 11
Corpus composition Ratio (w/w%) in the composition
Rosuvastatin calcium 6.93
Lactose 54.00
Microcrystalline cellulose 26.57
Magnesium hydroxide 5.00
Crospovidone 5.00
Povidone 1.50
Magnesium stearate 1.00
Example 12
Corpus composition Ratio (w/w%) in the composition
Rosuvastatin calcium 6.93
Lactose 55.55
Microcrystalline cellulose 29.02
Magnesium hydroxide 2.50
Calcium acetate 2.50
Crospovidone 2.50
Magnesium stearate 1.00
Example 13
Process for the production of the tablets according to our invention
The production of the tablets of Examples 9-12 consists of the following
steps:
1. The excipients are sieved.
2. The ingredients can be homogenized by two different methods:
2a. Blending in container blender:
6
CA 02662919 2011-05-31
The active ingredient and the excipients of the inner phase (lactose,
microcrystalline
cellulose, magnesium hydroxide and / or calcium acetate, crospovidone and in
case of need
povidone) are blended in the homogenization equipment with 20 rpm
(rotation/minute) stirring
speed for 5 minutes. Then the excipient of the external phase, magnesium
stearate, is added
to the powder mixture and the powder mixture is blended in the container
blender with 20 rpm
stirring speed for 2 minutes.
2b. Blending in high-shear mixer:
The active ingredient and the excipients of the inner phase (lactose,
microcrystalline
cellulose, magnesium hydroxide and / or calcium acetate, crospovidone and in
case of need
povidone) are blended in two portions in high-shear mixer, first for 3
minutes, then for 4
minutes.
Setting values:
Stirrer: 300 rpm
Chopper: 1050 rpm
Then the excipient of the external phase, magnesium stearate, is added to the
powder mixture
and the powder mixture is blended in high-shear mixer (stirrer: 300 rpm,
chopper: 1050 rpm)
or in the container blender (with 20 rpm stirring speed) for further 2
minutes.
3. The powder mixture homogenized with the external phase is compressed to
tablets in
a rotating tablet compressing machine.
Example 14
Production of film-coated tablets (5 mg, 10 mg, 20 mg and 40 mg)
The core tablets of Examples 9-12 are film-coated with an aqueous solution of
Opadry II White,
85FI 8422.
The amount of the coating is ¨ 3 % of that of the individual corpuses.
7
