Note : Les descriptions sont présentées dans la langue officielle dans laquelle elles ont été soumises.
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Method for Adjusting Level of Galanin in Brain by Optic Nerve Light Conduction
Technical Field
The present invention relates to a method for adjusting the level of galanin
in brain by
optic nerve light conduction.
Background
Galanin (GAL) is a regulatory peptide consisting of 30/29 (human/rodent) amino
acids. GAL is broadly distributed in the central and peripheral nervous
systems as well as
in non-neuronal tissues. Galanin peptide has a wide range of nonneuronal
functions as well
as classic neuro-modulatory roles. Galanin is important for a variety of
biological functions
such as feeding, pain processing, endocrine functions, neuroprotection, sleep,
mood change,
and sexual reproduction. It is believed that galanin expression level might be
especially
closely related to the pathogenesis of Alzheimer's disease (AD), anxiety and
depression,
insomnia, and sensitivity of pain caused by nerve injury.
Galanin has been shown to exerts its effects on numerous biological and
pathophysiological processes through three G-protein coupled receptors GLAR 1-
3. In the
cornea, GALR1-3 are detected in the stratum basal of epithelial cells, stromal
cells and
endothelial cells, and adjacent conjunctiva (Distribution of galanin receptors
in the human
eye, (Falk Schrodl, et al, Experimental Eye Research 138 (2015) 42-51). In the
iris,
GALR1-3 are found in the sphincter and dilator, and also in iris vessels. In
the ciliary body,
GALR1 are found only in non-pigmented epithelial cells, while GALR3 are found
in the
ciliary muscles and vessels. In the retina, GALR1's are present in a large
number of cells
and GLAR 2's in a small number of cells of GALR2; GALR3 's are also present in
a small
number of neurons and GALR2's are also found around the retinal vessels and
retinal
pigment epithelial cells together with GALR3. In the choroid, the presence of
GALR1-3
are detected in both endogenous choroidal neurons and nerve fibers of the
choroidal stroma,
and these three receptors may also be detected around the choroidal vessels,
while the
choroidal vascular layer seems to be only containing GALR3. Also GALR 1-3
present in
the eye might be related to the wound healing or inflammation process,
vascular dynamics
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and signal transduction.
Since the human eyes convert visual input into electrical information and
route this
information to the brain, research has shown that light of different
wavelengths and
frequencies (including visible light and invisible light) could generate
different signal
stimulation for GALR.
Further, research shows that light of different wavelengths and frequencies
(including
visible light and invisible light) may generate different signal stimulations
for GALR. A
marked alternation in galanin expression in the brain is observed under a
number of
conditions. This suggests a role for the neuropeptide and tis receptors for a
novel
therapeutic method. To be more specific, adjusting GAL in the brain by using
GALR in the
eye could influence the galanin expression in the brain. Due to the critical
role of galanin
in many biological processes, this method could have a wide range of
applications.
Summary
In view of this, the present invention provides a method for adjusting the
level of
galanin in the brain by optic nerve light conduction. The key idea or
procedure is to use
light of different wavelengths, different intensities and different
frequencies to illuminate
an eye by a light adjustment device in order to activate the galanin receptors
in the eye to
generate signals transmitted to the hypothalamic via the optic nerve. The
light of different
wavelengths, different intensities and different frequencies include visible
light and
invisible light.
The process of controlling the light of different wavelengths, different
intensities and
different frequencies to illuminate an eye will be done through filtering
natural light or
simulated natural light according to wavelengths in the order form large to
small and light
intensities and from strong to weak, until all light is blocked or turned off.
The process of controlling the light of different wavelengths, different
intensities and
different frequencies to illuminate an eye also comprises gradually recovering
the light
source according to wavelengths in the order from small to large and light
intensities from
weak to strong in the absence of other light source, until the natural light
or the simulated
natural light gradually illuminates the human eye.
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The wavelengths are in the order from large to small as follows: red light:
605-720nm,
orange light: 595-605nm, yellow light: 580-595nm, yellow-green light: 560-
580nm, green
light: 500-560nm, blue-green light: 490-500nm, cyan light: 480-490nm, blue
light: 450-
480nm, and purple light: 400- 435nm.
The light adjustment device comprises a light source, light filters and a
light filter
adjustment assembly; wherein the light source is natural light or simulated
natural light
using light-emitting devices; light filters which are used to filter light of
different
wavelengths respectively; and the light filter adjustment assembly is used for
adjusting the
position of the multiple light filters in order for the light filters to be
located either between
the light source and the eye or be removed completely.
The light adjustment device can be configured into an eyeshade-type product,
and a
conventional mobile or wearable component may be also selected as the light
filter
adjustment device.
In summary, the light adjustment apparatus comprises a light source, a light
wavelength control unit and a light frequency control unit, wherein the light
source of the
device is an array of light-emitting elements of different wavelengths; the
light wavelength
control unit controls the light-emitting elements of different wavelengths to
emit light
respectively through current connection; and the light frequency control unit
controls the
light-emitting intensities of the light-emitting elements of different
wavelengths
respectively through current pulse width. In the present invention, by
applying repeated
and well controlled light stimulation on the eye through light source signals
of different
wavelengths and frequencies, GALR in the eye may be activated, thus achieving
the
purpose of adjusting the level of the GAL in brain through optic nerve
conduction.
Detailed Description
Embodiment 1
A method for adjusting the level of galanin in brain by optic nerve light
conduction,
comprising the following step: controlling light of different wavelengths and
different
frequencies to illuminate an eye by a light adjustment device, so that galanin
receptors in
the eye are activated to produce signal stimulation, and signals transmitted
to the
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hypothalamic visual receiving area via the optic nerve can then influence the
level of
galanin expression in the brain.
The light adjustment device comprises a light source, multiple light filters
and a light
filter adjustment assembly, wherein the light source is simulated natural
light using light-
emitting elements; the light filters are multiple in number, which are used
for filtering light
of different wavelengths respectively; and the light filters are mounted on
the light filter
adjustment assembly; and the light filter adjustment assembly is used for
adjusting the
position of the multiple light filters to enable the light filters to be
located between the light
source and the eye or to be removed when necessary.
The light adjustment device is configured into an eyeshade-type product and is
worn
on the head while in use. The simulated natural light emitted by the light-
emitting elements
is made to illuminate the eye; then the light filter adjustment assembly is
controlled to
gradually superimpose the light filters between the light source and the eye
according to
wavelengths in the order from large to small to filter light, until all light
are blocked or
turned off.
The wavelengths are in the order from large to small as follows: red light:
605-720nm,
orange light: 595-605nm, yellow light: 580-595nm, yellow-green light: 560-
580nm, green
light: 500-560nm, blue-green light: 490-500nm, cyan light: 480-490nm, blue
light: 450-
480nm, and purple light: 400- 435nm.
Further, the light filters may be gradually removed according to wavelengths
in the
order from small to large, until the simulated natural light gradually
illuminates the human
eye.
Embodiment 2
A method for adjusting the level of galanin in brain by optic nerve light
conduction,
comprising the following step: controlling light of different wavelengths and
different
frequencies to illuminate an eye by a light adjustment device, so that galanin
receptors in
the eye are made to produce signal stimulation, and signals transmitted to the
hypothalamic
visual receiving area via the optic nerve to influence the level of galanin in
the brain.
The light adjustment device comprises a light source, a light wavelength
control unit
and a light frequency control unit, wherein the light source is an array of
light-emitting
elements of different wavelengths; LED lamps of different light wavelengths
may be
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arranged to form the array; the light wavelength control unit may select any
form of current
control elements to control currents of light-emitting elements of different
wavelengths
respectively, so that light-emitting elements of different wavelengths are
turned on or
turned off, and then illumination of light of different wavelengths is
achieved; and the light
frequency control unit may be set to control and adjust the light-emitting
intensities of the
light-emitting elements of different wavelengths respectively.
The light adjustment device is configured into an eyeshade-type product
(encapsulated in the eyeshade shell) and is worn on the outside of the eye
while in use; all
light-emitting elements in the array are controlled to emit light through
current, the
simulated natural light is made to illuminate the eye, then the light
frequency control unit
is controlled to reduce the light-emitting intensity of the light-emitting
element of the
maximum wavelength, the light-emitting element is controlled to be turned off
by the light
wavelength control unit, and the above-mentioned operation is repeatedly
performed on
the light-emitting elements of different wavelengths according to wavelengths
in the order
from large to small, until all light are turned off.
The wavelengths are in the order from large to small as follows: red light:
605-720nm,
orange light: 595-605nm, yellow light: 580-595nm, yellow-green light: 560-
580nm, green
light: 500-560nm, blue-green light: 490-500nm, cyan light: 480-490nm, blue
light: 450-
480nm, and purple light: 400- 435nm.
Further, the light-emitting elements may be gradually turned on according to
wavelengths in the order from small to large and light intensities in the
order from weak to
strong, until the simulated natural light gradually illuminates the human eye.
By adjustment of light of different wavelengths and different frequencies,
GALR 1-
3 in the eye may be activated to achieve the purpose of adjusting the level of
the GAL in
brain through optic nerve conduction. Since GAL is involved in mediating a
variety of
biological functions such as feeding, sense of pain, endocrine,
neuroprotection, learning
and memory, sleep, mood, sexuality and reproduction, it is expected to realize
the
intervention of biological response in vivo by adjustment of light of
different wavelengths
and different frequencies as a novel therapeutic measure.
Embodiment 3
A method for adjusting the level of galanin in brain by optic nerve light
conduction,
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comprising the following step: making blue light of 8-10Hz and red light of
0.5-411z
illuminate an eye by a light adjustment device in order to activate the GLAR 1-
3 in the eye
to achieve signal stimulation; and signals transmitted to the hypothalamic
visual receiving
area via the optic nerve can influence the level of galanin in the brain.
The light adjustment device comprises a light source, a light wavelength
control unit
and a light frequency control unit, wherein the light source is an array
formed by arranging
red light LED lamps and blue light LED lamps; the light wavelength control
unit may select
any form of current control elements to control currents of the red light LED
lamps and the
blue light LED lamps respectively, so that the red light LED lamps or the blue
light LED
lamps are turned on or turned off; and the light frequency control unit may
select any form
of current pulse width control elements to control the light-emitting
intensities of the red
light LED lamps and the blue light LED lamps respectively, thus adjusting the
intensities
of light.
The light adjustment device is configured into an eyeshade-type product and is
worn
on the eye while in use, the red light LED lamps in the array are controlled
to emit light
through the current, and then the light frequency control unit is controlled
to adjust the
frequency to 0.5-4Hz, thus reducing the level of galanin in the brain and
promoting sleep.
The blue light LED lamps in the array are controlled to emit light through the
current, and
then the light frequency control unit is controlled to adjust the frequency to
8-10Hz, thus
increasing the level of galanin in the brain and promoting wakeup.
The above description of the disclosed embodiments enables those skilled to
realize
or use the present invention. The general principle defined herein can be
realized in other
embodiments without departing from the spirit or scope of the present
invention. Therefore,
the present invention will not be limited to these embodiments shown herein,
but will
conform to the widest scope consistent with the principle and novel features
disclosed
herein.
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