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Sommaire du brevet 1083965 

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L'apparition de différences dans le texte et l'image des Revendications et de l'Abrégé dépend du moment auquel le document est publié. Les textes des Revendications et de l'Abrégé sont affichés :

  • lorsque la demande peut être examinée par le public;
  • lorsque le brevet est émis (délivrance).
(12) Brevet: (11) CA 1083965
(21) Numéro de la demande: 271366
(54) Titre français: PRODUIT CONTENANT DE LA GLUTARALDEHYDE EFFICACE POUR FAIRE RESORBER LES VERRUES
(54) Titre anglais: COMPOSITION CONTAINING GLUTARALDEHYDE FOR REMOVING WARTS
Statut: Périmé
Données bibliographiques
(52) Classification canadienne des brevets (CCB):
  • 167/280
(51) Classification internationale des brevets (CIB):
  • A61K 31/11 (2006.01)
  • A61K 47/10 (2017.01)
  • A61K 47/38 (2006.01)
(72) Inventeurs :
  • YARROW, HYMAN (Royaume-Uni)
  • WHITEFIELD, MARTIN (Royaume-Uni)
(73) Titulaires :
  • DERMAL LABORATORIES LIMITED (Afghanistan)
(71) Demandeurs :
(74) Agent: NORTON ROSE FULBRIGHT CANADA LLP/S.E.N.C.R.L., S.R.L.
(74) Co-agent:
(45) Délivré: 1980-08-19
(22) Date de dépôt: 1977-02-04
Licence disponible: S.O.
(25) Langue des documents déposés: Anglais

Traité de coopération en matière de brevets (PCT): Non

(30) Données de priorité de la demande:
Numéro de la demande Pays / territoire Date
04570/76 Royaume-Uni 1976-02-05

Abrégés

Abrégé anglais


ABSTRACT

New compositions of from 1% to 25% by weight of
glutaraldehyde, from 50% to 98% by weight of one or more
volatile, organic solvent(s) of from 1 to 4 carbon atoms
capable of forming a hydrogen bond with water or
glutaraldehyde, and from 1% to 45% by weight of water, in
which the percentage by weight of glutaraldehyde is at
least 1/9 of, but not more than equal to, the percentage
by weight of water, the percentages being based on the
combined weight of glutaraldehyde, solvent(s) and water
and the pH being from 3.5 to 7.0, are useful for the
removal of warts.

Revendications

Note : Les revendications sont présentées dans la langue officielle dans laquelle elles ont été soumises.



The embodiments of the invention, in which an
exclusive privilege or property is claimed, are defined as
follows:

1. A composition for removing warts which
comprises in a single phase from 1% to 25 % by weight
of glutaraldehyde, from 50 % to 98 % by weight of
one or more volatile, organic solvent(s) of from 1 to 4
carbon atoms capable of forming a hydrogen bond with
water or glutaraldehyde, and from 1 % to 45 % by weight of water,
in which the percentage by weight of glutaraldehyde is at
least 1/9 of, but not more than equal to, the percentage
by weight of water, the percentages being based on the
combined weight of glutaraldehyde, solvent(s) and water,
and the pH of the composition being from 3.5 to 7Ø
2. A composition according to claim 1, in which
the pH is from 3.5 to 5Ø
3. A composition according to claim 2, in which
the pH is from 4.2 to 4.4.
4. A composition according to claim 1 in which
the volatile organic solvent(s) is one or more of acetone,
and an alkanol of 1 to 3 carbon atoms.
5. A composition according to claim 4, in which
the alkanol is isopropanol or ethanol.
6. A composition according to claim 5, in
which the ethanol is in the form of industrial methylated
spirit.




7. A composition according to claim 1, in which
colouring material and/or perfume is additionally present.
8. A composition according to claim 1, in which
a thickener is additionally present.
9. A composition according to claim 8, in which
the thickener is methyl cellulose, pyroxylin or sodium
carboxymethyl cellulose.
10. A composition according to claim 1, in which
40 parts by weight of 25 % aqueous glutaraldehyde
solution and GO parts by weight of industrial methylated
spirit are present at a pH of 4.2.
11. A composition according to claim l, in which
5% by weight of glutaraldehyde, 5% by weight of water and 90%
by weight of collodion-acetone are present at a pH of 4.3.
12. A process for the manufacture of a
composition for removing warts which comprises mixing
together as constituents glutaraldehyde, water and one
or more volatile, organic solvent(s) of from l to 4 carbon
atoms capable of forming a hydrogen bond with water or
glutaraldehyde in any order or simultaneously in the
proportions of from 1% to 25% by weight of glutaraldehyde,
50% to 98% by weight of one or more volatile, organic
solvent(s) and from 1% to 25% by weight of water, such that
the resulting mixture has a pH of from 3.5 to 7.0, the
percentages being based on the combined weight of




glutaraldehyde, solvent(s) and water, and the percentage
by weight of glutaraldehyde being at least 1/9 of but not
more than equal to, the percentage by weight of water.
13. A process according to claim 12, in which
two of glutaraldehyde, water and the volatile organic
solvent(s) have been previously mixed together before
admixture with the remaining constituent.
14. A process according to claim 12 or 13, in
which 25 % or 50 % by weight aqueous glutaraldehyde
solution is used.
15. A process according to claim 12 in which the
volatile, organic solvent(s) is one or more of acetone,
and an alkanol of 1 to 3 carbon atoms.
16. A process according to claim 15, in which the
alkanol is isopropanol or ethanol.
17. A process according to claim 16, in which
the ethanol is in the form of industrial methylated spirit.
18. A process according to any one of claims
12 or 13, in which colouring material and/or perfume is
added to the mixture.
19. A process according to claim
12 in which a thickener is added to the mixture.
20. A process according to claim 19, in which
the thickener is methyl cellulose, pyroxylin or sodium
carboxymethyl cellulose.



Description

Note : Les descriptions sont présentées dans la langue officielle dans laquelle elles ont été soumises.


~39~iS
"
.
This invention relates to compositions for
topical application to the s]cin, and to their use,
especially in the removal of warts~ ~-
The presence of warts on the skin, while normally
painless and non-injurious to the person suffering from
them ~although planter warts can be very painful), can be
very disfiguring, especially when the warts are in a -~
prominent or cosmetically important place. There is, ~-
therefore, a need for a method for removing warts which
is simple, reliable, and harmless to the person having the
wart. Recent work has shown that glutaraldehyde in aqueous
solution can be used effectively to remove warts. THe
solution, normally containing 10% to 25% by weight of
glutaraldehyde in water and containing sufficient sodium
bicarbonate to bring the pH to 7.5, is applied repeatedly
- to the wart and after a few weeks the latter is removed.
This method, while effective, suffers from
certain disadvantages. In the first place, it is difficult
to apply the solution only to the wart, and, since
glutaraldehyde produces a brown stain on normal skin, this
means that the area surrounding the wart is normally
stained while treatment is going on, which can be a
~ ..
considerable disadvantage to the person being treated.
Secondly, after the solution has been applied, it is
necessary to wait until it dries in order that it should
not get rubbed off, and this means that the period of time
.
- 2 -

~0~33~365

required for application is inconveniently prolonged.
Thirdly, the solution of glutaraldehyde, if concentrated,
is not storage-stable due to polymerisation, and, if not
concentrated, is of only limited efficacy.
rrhe present invention provides a novel glutaralde-
hyde-containing composition useful for the removal of warts,
which is at least as effective as the known aqueous ~-
' glutaraldehyde solutions, and has important practical
advantages in useO
The present invention provides a composition - 3
for removing warts, which comprises in a single phase from
1 -to 25% by weight of glutaraldehyde, 50 to 98% by w,eight
' ' of one or more volatile organic solvents of from 1 to
carbon atoms capable of forming a hydrogen-bond with water
and/or glutaraldehyde, and 1 to 45% by weight of water, the
percentage by weight of glutaraldehyde being at least
1/9 o~, but not more than equal to, the percentage by
weight of water, the percentages being based on the combined ,
weight of glutaraldehyde, solvent(s) and water and the p~
of the composition being from 3.5 to 7Ø This composition
is applied to the warts until they disappear. A's compared
wi~h the known compositions containing glutaraldehyde used
for the treatment of warts, these new compositions have




., , .. ~: ,.. :: .. :.. , ,. ... . :, . ,

iL083~65

a much grea~r volatilit,y and are much easier to apply so
solely to the wart beiny treated. Moreover, after
application to the wart and evaporation of the volatile
solvent, they provide on the wart a high effective
concentration of glutaraldehyde, which can then act on
the wart before having a chance to polyrnerise. There is ~
no need for them to be 'ouffered to an alkaline pH, and, ; `
as ordinarily used, they should have a pH in the ran~e of
3.5 to 5.0 preferably from 4.2 to 4.4, at which pH they
are fully effective because of the high effective concen-
tration of the glutaraldehyde. Moreover, the new
compositions penetrate well into the treated wart.
This composition is prepared by mixin~ together
the constituents described above in any order, or
simultaneously, in the proportions detailed above. Of
,: ::
course, previously prepared mixtures of two constituents,
such as co~nercially available 25% by weight of 50% by
weight aqueous glutaraldehyde solution, may be used. It
is, not ordinarily desirable to add any other water to the
composition, s:ince the inclusion of too much water
unnecessarily reduces the volatility of the composition,
which is one of its practical advantages. ,~
The organic solvent, or mixture of solvents, used
must be capable of dissolving the glutaraldehyde and water
present so as to form a composition forming a single phase.



- 4
:~ :



: . - . : . : . .: . :::, . , .:. :.; , i.: .. - . .: . . ~ , ,

.. . . . ..

~1396~ :

Examples of such solvents are acetone, and preferably an
al]canol of 1 to 3 carbon atoms such as isopropanol or,
better, ethanol, which may be used in the fo~m of ~`~
industrial methylated spirit. Alkanols are further preferred
since they inhibit the polymerisation of the glutaraldehye~
it is believed by combining with the aldehyde groups in a
reversible equilibrium involving formation of hemiacetals
and acetals and release the free aldehyde on evaporation.
In order to improve its acceptability to the
user, the new ~ompositions may contain, in addition to the :
compounds already mentioned, an appropriate colouring
material and/or perfume. It may also, .if desired, contain
a thickener, such as methyl cellulose, pyroxylin, sodium;~
carboxymethyl cellu].ose in order to make even easier the
localisation of the treatment on the wart. It is, of :
course, essential that any such thickener, or other mater.ial
added, be soluble in the solvent or solvents used.
A preferred composition comprises 40 parts by
weight of 25% aqueous glutaraldehyde solution (providing
10 parts by weight of glutaraldehyde and 30 parts by weight
water) and 60 parts by weight of industrial methylated
spirity (typ.ically 5 volumes methanol per 100 volumes 190
(IJ.S.) proof ethanol) at a pH of 4.2.
A second preferred cornposition consi.sts of 5% by
weight of glutaraldehyde, 5% by weight of water, and 90% by




- :
,




`~- ` : - ` ~ ; : -~ ;?

1~839~

weight of a compositio~ known as collodion-acetone of 5g
pyroxylin (a mixture of nitrated polysaccharides of high
molecular weight (C6H1005)n, consisting of at least 200
glycopyranose units such that there are 2 to 2~ nitrate
groups per sugar unit) in 2.5 ml castor oil.and 10 ml
ethoxyethanol, further made up to 100 ml with acetone
at a pH of 4.3. These compositions may be coloured,
perfumed and/or thi~kened as desired i.n the manner already
indicated.
By a~plying the new cosmetic compositions on to `~
a wart, it is possible to totally eradicate painful and
disfiguring warts from the epidermis of someone suffering
therefrom, and it has been found that the removal is often
permanent with no re-growth of the treated w~rts. The
application of the composition re~uires no skill and is
easily carried out by the user in the peace and priva~y of
his or her own dwelling. The method of eradicating warts
using the new compositions is therefore within the scope
of the invention.




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,: . ~

Dessin représentatif

Désolé, le dessin représentatatif concernant le document de brevet no 1083965 est introuvable.

États administratifs

Pour une meilleure compréhension de l'état de la demande ou brevet qui figure sur cette page, la rubrique Mise en garde , et les descriptions de Brevet , États administratifs , Taxes périodiques et Historique des paiements devraient être consultées.

États administratifs

Titre Date
Date de délivrance prévu 1980-08-19
(22) Dépôt 1977-02-04
(45) Délivré 1980-08-19
Expiré 1997-08-19

Historique d'abandonnement

Il n'y a pas d'historique d'abandonnement

Historique des paiements

Type de taxes Anniversaire Échéance Montant payé Date payée
Le dépôt d'une demande de brevet 0,00 $ 1977-02-04
Titulaires au dossier

Les titulaires actuels et antérieures au dossier sont affichés en ordre alphabétique.

Titulaires actuels au dossier
DERMAL LABORATORIES LIMITED
Titulaires antérieures au dossier
S.O.
Les propriétaires antérieurs qui ne figurent pas dans la liste des « Propriétaires au dossier » apparaîtront dans d'autres documents au dossier.
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Description du
Document 
Date
(yyyy-mm-dd) 
Nombre de pages   Taille de l'image (Ko) 
Dessins 1994-04-07 1 12
Revendications 1994-04-07 3 149
Abrégé 1994-04-07 1 36
Page couverture 1994-04-07 1 34
Description 1994-04-07 5 241