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CA 02394033 2002-06-10
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IBD-RELATED POLYMORPHISMS
RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application Serial
No. 60/170,257, filed December 10, 1999, and U.S. Provisional Application
Serial
No. 60/196,046, filed April 10, 2000, the entire teachings of both of which
are
incorporated herein by reference in their entirety.
BACKGROUND OF THE 'INVENTION
The genomes of all organisms undergo spontaneous mutation in the course
of their continuing evolution, generating variant forms of progenitor nucleic
acid
sequences (Gusella, Ann. Rev. Biochem. 55, 831-854 (1986)). The variant form
may
confer an evolutionary advantage or disadvantage relative to a progenitor
form, or
may be neutral. In some instances, a variant form confers a lethal
disadvantage and
is not transmitted to subsequent generations of the organism. In other
instances, a
variant form confers an evolutionary advantage to the species and is
eventually
incorporated into the DNA of many or most members of the species and
effectively
becomes the progenitor form. In many instances, both progenitor and variant
forms) survive and co-exist in a species population. The coexistence of
multiple
forms of a sequence gives rise to polymorphisms.
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Several different types of polymorphism have been reported. A restriction
fragment length polymorphism (RFLP) is a variation in DNA sequence that alters
the length of a restriction fragment (Botstein et al., Am. J. Hum. Genet. 32,
314-331
(1980)). The restriction fragment length polymorphism may create or delete a
restriction site, thus changing the length of the restriction fragment. RFLPs
have
been widely used in human and animal genetic analyses (see WO 90/13668;
W090/11369; Donis-Keller, Cell Sl, 319-337 (1987); Lander et al., Genetics
121,
85-99 (1989)). When a heritable trait can be linked to a particular RFLP, the
presence of the RFLP in an individual can be used to predict the likelihood
that the
animal will also exhibit the trait.
Other polymorphisms take the form of short tandem repeats (STRs) that
include tandem di-, tri- and tetra-nucleotide repeated motifs. These tandem
repeats
are also referred to as variable number tandem repeat (VNTR) polymorphisms.
VNTRs have been used in identity and paternity analysis (US 5,075,217; Armour
et
al., FEBS Lett. 307, 113-115 (1992); Horn et al., WO 91/14003; Jeffreys, EP
370,719), and in a large number of genetic mapping studies.
Other polymorphisms take the form of single nucleotide variations between
individuals of the same species. Such polymorphisms are far more frequent than
RFLPs, STRs and VNTRs. Some single nucleotide polymorphisms (SNP) occur in
protein-coding nucleic acid sequences (coding sequence SNP (cSNP)), in which
case, one of the polymorphic forms may give rise to the expression of a
defective or
otherwise variant protein and, potentially, a genetic disease. Examples of
genes in
which polymorphisms within coding sequences give rise to genetic disease
include
~i-globin (sickle cell anemia), apoE4 (Alzheimer's Disease), Factor V Leiden
(thrombosis), and CFTR (cystic fibrosis). cSNPs can alter the codon sequence
of the
gene and therefore specify an alternative amino acid. Such changes are called
"missense" when another amino acid is substituted, and "nonsense" when the
alternative codon specifies a stop signal in protein translation. When the
cSNP does
not alter the amino acid specified the cSNP is called "silent". Other single
nucleotide polymorphisms occur in noncoding regions. Some of these
polymorphisms may also result in defective protein expression (e.g., as a
result of
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defective splicing). Other single nucleotide polymorphisms have no phenotypic
effects.
Single nucleotide polymorphisms can be used in the same manner as RFLPs
and VNTRs, but offer several advantages. Single nucleotide polymorphisms occur
with greater frequency and are spaced more uniformly throughout the genome
than
other forms of polymorphism. The greater frequency and uniformity of single
nucleotide polymorphisms means that there is a greater probability that such a
polymorphism will be found in close proximity to a genetic locus of interest
than
would be the case for other polymorphisms. The different forms of
characterized
single nucleotide polymorphisms are often easier to distinguish than other
types of
polymorphism (e.g., by use of assays employing allele-specific hybridization
probes
or primers).
Only a small percentage of the total repository of polymorphisms in humans
and other organisms has been identified. The limited number of polymorphisms
identified to date is due to the large amount of work required for their
detection by
conventional methods. For example, a conventional approach to identifying
polymorphisms might be to sequence the same stretch of DNA in a population of
individuals by dideoxy sequencing. In this type of approach, the amount of
work
increases in proportion to both the length of sequence and the number of
individuals
in a population and becomes impractical for large stretches of DNA or large
numbers of persons.
SUMMARY OF THE INVENTION
Work described herein pertains to the identification of polymorphisms which
are associated with inflammatory bowel diseases (IBD), and particularly those
within a single risk haplotype, by resequencing large numbers of genes and
gene
fragments in a large number of individuals. Various genes from a number of
individuals have been resequenced as described herein, and SNPs in these genes
have been discovered (see Table 3). Some of these SNPs are cSNPs which specify
a
different amino acid sequence, some of the SNPs are silent cSNPs and some of
these
cSNPs specify a stop signal in protein translation. Some of the identified
SNPs were
located in non-coding regions.
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With the goal of identifying IBD susceptibility genes, a genomewide scan was
undertaken in 163 pedigrees, and three regions of suggestive linkage (3, Sq31-
33,
6p) and one of'significant linkage to 19p13 (LOD = 4.6) were identified.
Higher
density mapping in the suggestive Sq31-33 region revealed a CD susceptibility
locus
of genome-wide significance (LOD = 3.9). Importantly, the Sq31-p33 localizes
to
the maj or immunoregulatory cytokine gene cluster and the 19p 13 locus to a
region
containing numerous genes encoding cytokine/chemokine receptors and other
inflammatory-associated molecules that could have a direct role in disease
susceptibility.
In order to pursue the evidence of linkage to chromosome S, a systematic
linkage disequilibrium (LD) approach was adopted. The approach that was used
in
the first stage of LD mapping was to genotype all known microsatellite markers
in
the 18 cM between DSS1435 and DSS1480, as these two markers delimit a region
of
a 2 LOD drop on either side of the linkage peak centered at marker DSS2497.
All
alleles for each marker were examined for evidence of excess transmission from
heterozygous parents to CD child using the transmission disequilibrium test
(TDT).
Only alleles at two of the 57 markers had significant CZ results (p<0.001 ):
IRF 1p 1
(CZ=13.3, p=0.0003) and DSS1984 (CZ=14.0, p=0.0002) (Table 1). A second stage
of mapping was then undertaken to confirm, as well as to better delimit, the
region
of LD surrounding IRFlpland DSS1984. The development of new microsatellite
markers was necessary. The marker with the most significant CZ result was
CAhl7a
(CZ=16.2, p=0.00006) and was located between IRFlpland DSS1984 (Table 2).
Furthermore, the alleles 193, 156, 373, 140, 222, and 307 at markers GAhl8a,
IRFIp, CAhlSa, CAhl7a, DSS1984, CSF2p10, respectively, define a haplotype
conferring susceptibility to Crohn's disease (CD). In order to identify the
sequence
variant that would explain the genetic susceptibility to CD provided by this
haplotype, a search was performed for all single nucleotide polymorphisms
(SNPs)
in this region of LD. The SNP discovery was accomplished by direct sequencing
of
overlapping PCR products amplified from DNA samples from eight individuals
(six
CD patients, one unaffected family member, and one CEPH DNA as control). Table
3 shows the results of the SNP discovery analyses.
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139 triads were genotyped for a total of 241 SNPs thus far, where at least 50
trios were fully genotyped. Using a CZ value of 13 (corresponding to a p-value
of
0.05) as threshold, 12 SNPs were found to have a significant level of
association
with CD and extended over a region of 250 kb, from IRF 1 to prolyl4
hydroxylase.
These were markers IGR2055a 1, IGR2060a 1, IGR2063b_1, IGR2069a 2,
IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a l, IGR3081a l,
IGR3096a 1, PROLYLex3_1 (see Table 4). Any of these best SNPs by themselves
are in strong association with CD and fully explain the microsatellite LD
observations. Furthermore, the best SNPs have nearly identical association
characteristics (that is, the allele at one SNP determines the allele of all
others on
any phased chromosome), confirming that a single risk haplotype extending
approximately 250 kb is the source of all the observations of association in
this
region. Specifically, this haplotype is defined by the alleles G, C, G, T, A,
A, G, T,
G, G, C, T at markers IGR2055a 1, IGR2060a 1, IGR2063b-1, IGR2069a 2,
IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a 1,
IGR3096a 1, PROLYLex3-1, respectively. The frequency of this haplotype is
estimated to be approximately 37% in the general population. Furthermore, this
haplotype is transmitted from heterozygous parents to CD patients at a ratio
of 2.5:1.
The invention relates to a isolated gene or nucleic acid molecule which
comprises a single nucleotide polymorphism at a specific location. In a
particular
embodiment the invention relates to the variant allele of a gene having a
single
nucleotide polymorphism, which variant allele differs from a reference allele
by one
nucleotide at the sites) identified in Table 3. Complements of these nucleic
acid
segments are also included. The segments can be DNA or RNA, and can be double-
or single-stranded. Segments can be, for example, 5-10, 5-15, 10-20, 5-25, 10-
30,
10-50 or 10-100 bases long.
The invention further provides allele-specific oligonucleotides that hybridize
to a gene comprising a single nucleotide polymorphism or to the complement of
the
gene. These oligonucleotides can be probes or primers.
The invention further provides a method of analyzing a nucleic acid from an
individual. The method determines which base is present at any one of the
polymorphic sites shown in Table 3. Optionally, a set of bases occupying a set
of
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the polymorphic sites shown in Table 3 is determined. This type of analysis
can be
performed on a number of individuals, who are tested for the presence of a
disease
phenotype. The presence or absence of disease phenotype is then correlated
with a
base or set of bases present at the polymorphic site or sites in the
individuals tested.
Thus, the invention further relates to a method of predicting the presence,
absence, likelihood of the presence or absence, or severity of a particular
phenotype
or disorder associated with a particular genotype. The method comprises
obtaining a
nucleic acid sample from an individual and determining the identity of one or
more
bases (nucleotides) at polymorphic sites of genes described herein, wherein
the
presence of a particular base is correlated with a specified phenotype or
disorder,
thereby predicting the presence, absence, likelihood of the presence or
absence, or
severity of the phenotype or disorder in the individual. In one embodiment of
the
invention, the phenotype is inflammatory bowel disease or Crohn's disease.
BRIEF DESCRIPTION OF THE DRAWING
1 S The Figure shows multipoint nonparametric linkage results for the IBD
genome scan. Multipoint LOD scores were calculated using the
MAPMAKER/SIBS functions implemented in GENHUNTER 2Ø The thick black
line indicates the LOD score along the length of each chromosome, and the tick
marks indicate the position of the microsatellite markers. The two horizontal
lines
depict the genome-wide thresholds for suggestive (LOD = 2.0) and significant
linkage.
DETAILED DESCRIPTION OF THE INVENTION
Crohn's disease (CD) and ulcerative colitis (UC) are chronic, idiopathic
inflammatory disorders of the gastrointestinal tract. These inflammatory bowel
diseases (IBD) have a peak incidence in early adulthood, and their combined
prevalence is approximately 100-200/100,000. The inflammation in IBD is
characterized by altered expression of both pro-inflammatory and
immunoregulatory
cytokines in the affected intestinal mucosa (Kmiec, Arch Immunol Ther Expe
(Warsz) 46(3):143-155 (1998)). Genetic factors are believed to play an
important
role, as the sibling risk (~,S) calculated for IBD ranges from 1 S-40, with a
stronger
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genetic contribution occurring for CD (~,5~ 35) as compared to UC (~,S ~ 15).
Additionally, relatives of individuals with IBD diagnosed at younger ages
appear to
be at an even higher risk.
CD is characterized by discontinuous, transmural inflammation affecting any
part of the gastrointestinal tract and is manifested by abdominal pain,
chronic
diarrhea, weight loss, bowel obstructions and fistulae. UC occurs as a
continuous,
mucosal inflammation affecting only the large intestine with primary symptoms
including diarrhea, rectal bleeding and abdominal pain. The search for
susceptibility
genes for these two diseases has resulted in the identification of two
potential
susceptibility loci. The first, called IBDI, is a CD-susceptibility locus that
lies in the
pericentromeric region of chromosome 16 (Hugo et al., Nature 379:821-822
(1996)). The second (IBD2) is located in a 41 cM region surrounding marker
D12S83 and appears to be linked to both CD and UC (Satsangi et al., Genetics
14:199-202 (1996)). These putative loci, however, have only been replicated in
some, but not all, subsequent studies (Cavanaugh et al., Proc Natl Acad Sci
USA
62:291-298 (1998); Cho et al., The National Academy of Sciences 95:7502-7507
(1998); Curren et al., Gastroenterology 115:1-7 (1998); Duerr et al., The
American
Society of Human Genetics 63:95-100 (1998); Rioux et al., Am. J. Hum. Genet.
63:1086-1094 (1998); Yang et al., Gastroenterology 109:440-448 (1995)),
supporting the belief that there exists substantial genetic heterogeneity.
Furthermore, IBDI and IBD2 only account for a fraction of the heritability of
IBD,
suggesting that additional loci contribute to disease susceptibility. Thus, as
described herein, the susceptibility loci in a Canadian IBD population was
assessed
by studying families with multiple affected siblings (McLeod et al., Dis Colon
Rectum 40:553-557 (1997)).
A genome-wide screen was performed on 181 IBD-affected sibling pairs
(ASP) and 5 IBD-affected relative pairs (RP) from 163 families. Among these
ASP,
122 were CD pairs, .25 were UC pairs, and 34 were "mixed" pairs (one sibling
with
either CD or UC, the other with CD, UC or IC). All ASP and available parents
(140
families had both parents available, 17 had one parent available, and 1 was
missing
both parents), as well as all RP, were genotyped with 312 microsatellite
markers
covering the genome with approximately 12 cM distance between markers.
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Simulations of this dataset indicated that the genome-wide threshold for
suggestive
linkage (the score expected to occur one time at random in a genome scan) was
at a
LOD of 2Ø Using either this calculated threshold, or the published threshold
of
LOD 2.2 based on an infinitely dense map (Lander & Kruglyak, Nature Genetics
11:241-247 (1995)), multipoint nonparametric linkage analysis of these data
revealed 4 loci which surpassed this threshold (Figure). Specifically,
chromosome 3
had a peak LOD of 2.4 between markers D3 S 1766 and D#S 1285, chromosome 5 a
peak LOD of 3.0 between GATA68A03 and DSS816, chromosome 6 a peak LOD of
2.3 between D6S 1019 and D6S 1017, and chromosome 19 a peak LOD of 4.6
between GATA21G05 and D19S586. In fact this chromosome 19 locus exceeds the
threshold for genome-wide significance of 3.6 (Lander & Kruglyak, Nature
Genetics
11:241-247 (1995)), and represents a novel IBD susceptibility locus.
This novel locus maps to an extended region on 19p 13 (Figure) that contains
many different genes of immunologic interest such as intercellular adhesion
molecule 1 (ICAM1), complement component 3 (C3), the thromboxane A2 receptor
(TBXA2), leukotriene B4 hydroxylase (LTB4H), and the janus tyrosine kinases
TYK2 and JAK3. There is some evidence supporting their relevance in IBD
susceptibility: 1) modest positive association results have been reported for
the
ICAM1 (Yang et al., Gastroenterology 109:440-448 (1995)) and C3 molecules
(Elmgreen et al., Acta Med Scand 215(4):375-8 (1984)); 2) attempts to
interfere
with the TBXA2 (Taniguchi, 1997) and LTB4 (Hawkey et al., Agents Actions,
Special Conference Issue (1992)) mediated inflammatory pathways have shown
some therapeutic value; and 3) the janus kinases have been shown to be
important in
the transduction of the molecular signal from cytokine receptors.
The finding of suggestive linkage to an approximately 30 cM region spanning
the cytokine gene cluster on Sq31-q33, containing many of the immunoregulatory
cytokines such as IL4, IL13, ILS and IL3, led to the performance of higher
density
mapping in this region. Specifically, the original families and an additional
12
families were genotyped for 34 extra microsatellite markers. Multipoint
nonparametric analysis were then performed using three different phenotypic
categories: IBD, CD and CD 16. In the first, all individuals with CD, UC or IC
were
designated as affected; in the second, only individuals with CD were
designated as
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affected; in the third, only individuals with CD were designated as affected
and only
families with at least one affected sibling diagnosed at the age of 16 or
younger were
included. This last category was examined due to an expected enrichment for
genetic factors over environmental causes. These analyses demonstrate the
presence
S of a locus of genome-wide significance in the group with early onset CD (MLS
=
3.9). Evidence for linkage to the syntenic region in mice has been reported in
an
induced model of colitis (Mahler, Genomics 55:147-156 (1999)).
Although the suggestive loci on chromosomes 3 and 6 identified as described
herein have not yet been followed up with higher density mapping, it is
important to
note that the linkage peak on chromosome 3 is approximately 10 cM away from a
previously reported suggestive locus (Satsangi et al., Nature Genetics 14:199-
202
(1996)), and the linkage peak on 6 lies approximately 20 cM centromeric to the
major histocompatibility complex (MHC) Class II region. A recent study has
described linkage to this chromosome 6 region (Hampe et al., Am. J. Hum.
Genet.
64 (1999)), and a large meta-analysis of the results derived from 29 different
studies
has also reported that both CD and UC were associated with specific Class II
alleles
(Stokkers et al., Gut 45:395-401 (1999)). Finally, in order to assess whether
the
IBDI and IBD2 loci are contributing to the IBD susceptibility in this
population,
exclusion mapping of the data was performed. These analyses demonstrate that
the
entire chromosome 12 can be excluded for loci of even modest effects (~,S >
1.5), but
can only loci conferring a ~,S > 4 on chromosome 16 can be excluded,
suggesting
that IBD1 (~,S ~ 1.3) could have gone undetected in the present study.
Thus, this work has identified two novel susceptibility loci: a locus on
chromosome Sq31-33 that confers susceptibility to CD and a locus on chromosome
19p13 that confers susceptibility to IBD. Furthermore, particular SNPs within
these
loci have been identified which may be associated with disease susceptibility.
The present invention relates to a gene which comprises a single nucleotide
polymorphism (SNP) at a specific location. The gene which includes the SNP has
at
least two alleles, referred to herein as the reference allele and the variant
allele. The
reference allele (prototypical or wild type allele) has been designated
arbitrarily and
typically corresponds to the nucleotide sequence of the gene which has been
deposited with GenBank or TIGR under a given Accession number. The variant
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allele differs from the reference allele by one nucleotide at the sites)
identified in
Table 3. The present invention also relates to variant alleles of the
described genes
and to complements of the variant alleles. The invention further relates to
portions
of the variant alleles and portions of complements of the variant alleles
which
comprise (encompass) the site of the SNP and are at least 5 nucleotides in
length.
Portions can be, for example, 5-10, 5-15, 10-20, 5-25, 10-30, 10-50 or 10-100
bases
long. For example, a portion of a variant allele which is 21 nucleotides in
length
includes the single nucleotide polymorphism (the nucleotide which differs from
the
reference allele at that site) and twenty additional nucleotides which flank
the site in
the variant allele. These nucleotides can be on one or both sides of the
polymorphism.
Polymorphisms which are the subject of this invention are defined in Table 3.
The reference sequence for many of the genes or gene fragments is provided in
Table 5. For sequences which are not present in Table 5, the skilled artisan
can
readily determine the specific location of the polymorphism given the 3' and
5'
nucleotide sequence flanking the polymorphic site provided in Table 3 and the
chromosomal loci information provided herein. The nucleotide sequences of the
invention can be double- or single-stranded.
The invention further provides allele-specific oligonucleotides that hybridize
to a gene comprising a single nucleotide polymorphism or to the complement of
the
gene. These oligonucleotides can be probes or primers.
The invention further provides a method of analyzing a nucleic acid from an
individual. The method determines which base is present at any one of the
polymorphic sites shown in Table 3. Optionally, a set of bases occupying a set
of
the polymorphic sites shown in Table 3 is determined. This type of analysis
can be
performed on a number of individuals, who are tested for the presence of a
disease
phenotype. The presence or absence of disease phenotype is then correlated
with a
base or set of bases present at the polymorphic site or sites in the
individuals tested.
Thus, the invention further relates to a method of predicting the presence,
absence, likelihood of the presence or absence, or severity of a particular
phenotype
or disorder associated with a particular genotype. The method comprises
obtaining a
nucleic acid sample from an individual and determining the identity of one or
more
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bases (nucleotides) at polymorphic sites of genes described herein, wherein
the
presence of a particular base is correlated with a specified phenotype or
disorder,
thereby predicting the presence, absence, likelihood of the presence or
absence, or
severity of the phenotype or disorder in the individual.
DEFINITIONS
An oligonucleotide can be DNA or RNA, and single- or double-stranded.
Oligonucleotides can be naturally occurring or synthetic, but are typically
prepared
by synthetic means. Preferred oligonucleotides of the invention include
segments of
DNA, or their complements, which include any one of the polymorphic sites
shown
in Table 3. The segments can be between 5 and 250 bases, and, in specific
embodiments, are between 5-10, 5-20, 10-20, 10-50, 20-50 or 10-100 bases. For
example, the segment can be 21 bases. The polymorphic site can occur within
any
position of the segment. The segments can be from any of the allelic forms of
DNA
shown in Table 3.
As used herein, the terms "nucleotide", "base" and "nucleic acid" are intended
to be equivalent. The terms "nucleotide sequence", "nucleic acid sequence",
"nucleic acid molecule" and "segment" are intended to be equivalent.
Hybridization probes are oligonucleotides which bind in a base-specific
manner to a complementary strand of nucleic acid. Such probes include peptide
nucleic acids, as described in Nielsen et al., Science 254, 1497-1500 (1991).
Probes
can be any length suitable for specific hybridization to the target nucleic
acid
sequence. The most appropriate length of the probe may. vary depending upon
the
hybridization method in which it is being used; for example, particular
lengths may
be more appropriate for use in microfabricated arrays, while other lengths may
be
more suitable for use in classical hybridization methods. Such optimizations
are
known to the skilled artisan. Suitable probes and primers can range from about
5
nucleotides to about 30 nucleotides in length. For example, probes and primers
can
be 5, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 25, 26, 28 or 30 nucleotides in
length. The
probe or primer preferably overlaps at least one polymorphic site occupied by
any of
the possible variant nucleotides. The nucleotide sequence can correspond to
the
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coding sequence of the allele or to the complement of the coding sequence of
the
allele.
As used herein, the term "primer" refers to a single-stranded oligonucleotide
which acts as a point of initiation of template-directed DNA synthesis under
appropriate conditions (e.g., in the presence of four different nucleoside
triphosphates and an agent for polymerization, such as DNA or RNA polymerase
or
reverse transcriptase) in an appropriate buffer and at a suitable temperature.
The
appropriate length of a primer depends on the intended use of the primer, but
typically ranges from 15 to 30 nucleotides. Short primer molecules generally
require cooler temperatures to form sufficiently stable hybrid complexes with
the
template. A primer need not reflect the exact sequence of the template, but
must be
sufficiently complementary to hybridize with a template. The term primer site
refers
to the area of the target DNA to which a primer hybridizes. The term primer
pair
refers to a set of primers including a 5' (upstream) primer that hybridizes
with the S'
end of the DNA sequence to be amplified and a 3' (downstream) primer that
hybridizes with the complement of the 3' end of the sequence to be amplified.
As used herein, linkage describes the tendency of genes, alleles, loci or
genetic
markers to be inherited together as a result of their location on the same
chromosome. It can be measured by percent recombination between the two genes,
alleles, loci or genetic markers.
As used herein, polymorphism refers to the occurrence of two or more
genetically determined alternative sequences or alleles in a population. A
polymorphic marker or site is the locus at which divergence occurs. Preferred
markers have at least two alleles, each occurring at frequency of greater than
1 %,
and more preferably greater than 10% or 20% of a selected population. A
polymorphic locus may be as small as one base pair. Polymorphic markers
include
restriction fragment length polymorphisms, variable number of tandem repeats
(VNTR's), hypervariable regions, minisatellites, dinucleotide repeats,
trinucleotide
repeats, tetranucleotide repeats, simple sequence repeats, and insertion
elements
such as Alu. The first identified allelic form is arbitrarily designated as
the reference
form and other allelic forms are designated as alternative or variant alleles.
The
allelic form occurnng most frequently in a selected population is sometimes
referred
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to as the wildtype form. Diploid organisms may be homozygous or heterozygous
for allelic forms. A diallelic or biallelic polymorphism has two forms. A
triallelic
polymorphism has three forms.
Work described herein pertains to the resequencing of large numbers of genes
in a large number of individuals to identify polymorphisms which can
predispose
individuals to disease, particularly IBD.
By altering amino acid sequence, SNPs may alter the function of the encoded
proteins. The discovery of the SNP facilitates biochemical analysis of the
variants
and the development of assays to characterize the variants and to screen for
pharmaceutical that would interact directly with on or another form of the
protein.
SNPs (including silent SNPs) may also alter the regulation of the gene at the
transcriptional or post-transcriptional level. SNPs (including silent SNPs)
also
enable the development of specific DNA, RNA, or protein-based diagnostics that
detect the presence or absence of the polymorphism in particular conditions.
- A single nucleotide polymorphism occurs at a polymorphic site occupied by a
single nucleotide, which is the site of variation between allelic sequences.
The site
is usually preceded by and followed by highly conserved sequences of the
allele
(e.g., sequences that vary in less than 1/100 or 1/1000 members of the
populations).
A single nucleotide polymorphism usually arises due to substitution of one
nucleotide for another at the polymorphic site. A transition is the
replacement of
one purine by another purine or one pyrimidine by another pyrimidine. A
transversion is the replacement of a purine by a pyrimidine or vice versa.
Single
nucleotide polymorphisms can also arise from a deletion of a nucleotide or an
insertion of a nucleotide relative to a reference allele. Typically the
polymorphic
site is occupied by a base other than the reference base. For example, where
the
reference allele contains the base "T" at the polymorphic site, the altered
allele can
contain a "C", "G" or "A" at the polymorphic site.
Hybridizations are usually performed under stringent conditions, for example,
at a salt concentration of no more than 1 M and a temperature of at least
25°C. For
example, conditions of SX SSPE (750 mM NaCI, 50 mM NaPhosphate, 5 mM
EDTA, pH 7.4) and a temperature of 25-30°C, or equivalent conditions,
are suitable
for allele-specific probe hybridizations. Equivalent conditions can be
determined by
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varying one or more of the parameters given as an example, as known in the
art,
while maintaining a similar degree of identity or similarity between the
target
nucleotide sequence and the primer or probe used.
The term "isolated" is used herein to indicate that the material in question
exists in a physical milieu distinct from that in which it occurs in nature.
For
example, an isolated nucleic acid of the invention may be substantially
isolated with
respect to the complex cellular milieu in which it naturally occurs. In some
instances, the isolated material will form part of a composition (for example,
a crude
extract containing other substances), buffer system or reagent mix. In other
circumstance, the material may be purified to essential homogeneity, for
example as
determined by PAGE or column chromatography such as HPLC. Preferably, an
isolated nucleic acid comprises at least about S0, 80 or 90 percent (on a
molar basis)
of all macromolecular species present.
I. Novel Polymorphisms of the Invention
The novel polymorphisms of the invention are shown in Table 3.
II. Analysis of Polymorphisms
A. Preparation of Samples
Polymorphisms are detected in a target nucleic acid from an individual being
analyzed. For assay of genomic DNA, virtually any biological sample (other
than
pure red blood cells) is suitable. For example, convenient tissue samples
include
whole blood, semen, saliva, tears, urine, fecal material, sweat, buccal, skin
and hair.
For assay of cDNA or mRNA, the tissue sample must be obtained from an organ in
which the target nucleic acid is expressed. For example, if the target nucleic
acid is
a cytochrome P450, the liver is a suitable source.
Many of the methods described below require amplification of DNA from
target samples. This can be accomplished by e.g., PCR. See generally PCR
Technology: Principles and Applications for DNA Amplification (ed. H.A.
Erlich,
Freeman Press, NY, NY, 1992); PCR Protocols: A Guide to Methods and
Applications (eds. Innis, et al., Academic Press, San Diego, CA, 1990); Manila
et
al., Nucleic Acids Res. 19, 4967 (1991 ); Eckert et al., PCR Methods and
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Applications 1, 17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and
U.S. Patent 4,683,202.
Other suitable amplification methods include the ligase chain reaction (LCR)
(see Wu and Wallace, Genomics 4, 560 (1989), Landegren et al., Science 241,
1077
(1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA
86,
1173 (1989)), and self sustained sequence replication (Guatelli et al., Proc.
Nat.
Acad. Sci. USA, 87, 1874 (1990)) and nucleic acid based sequence amplification
(NASBA). The latter two amplification methods involve isothermal reactions
based
on isothermal transcription, which produce both single stranded RNA (ssRNA)
and
double stranded DNA (dsDNA) as the amplification products in a ratio of about
30
or 100 to 1, respectively.
B. Detection of Polymorphisms in Target DNA
The polymorphisms identified as described herein can be used as a platform
for genotyping (i.e., determining the genotype of) individuals. This analysis
determines which forms) of a characterized (known) polymorphism are present in
individuals under test. There are a variety of suitable procedures, which are
discussed in turn.
1. Allele-Specific Probes
The design and use of allele-specific probes for analyzing polymorphisms is
described by e.g., Saiki et al., Nature 324, 163-166 (1986); Dattagupta, EP
235,726,
Saiki, WO 89/11548. Allele-specific probes can be designed that hybridize to a
segment of target DNA from one individual but do not hybridize to the
corresponding segment from another individual due to the presence of different
polymorphic forms in the respective segments from the two individuals.
Hybridization conditions should be sufficiently stringent that there is a
significant
difference in hybridization intensity between alleles, and preferably an
essentially
binary response, whereby a probe hybridizes to only one of the alleles. Some
probes
are designed to hybridize to a segment of target DNA such that the polymorphic
site
aligns with a central position (e.g., in a 15-mer at the 7 position; in a 16-
mer, at
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either the 8 or 9 position) of the probe. This design of probe achieves good
discrimination in hybridization between different allelic forms.
Allele-specific probes are often used in pairs, one member of a pair showing a
perfect match to a reference form of a target sequence and the other member
showing a perfect match to a variant form. Several pairs of probes can then be
immobilized on the same support for simultaneous analysis of multiple
polymorphisms within the same target sequence.
2. Tiling Arrays
The polymorphisms can also be identified by hybridization to nucleic acid
arrays, some examples of which are described in WO 95/11995. One form of such
arrays is described in the Examples section in connection with de novo
identification
of polymorphisms. The same array or a different array can be used for analysis
of
characterized polymorphisms. WO 95/11995 also describes subarrays that are
optimized for detection of a variant form of a precharacterized polymorphism.
Such
1 S a subarray contains probes designed to be complementary to a second
reference
sequence, which is an allelic variant of the first reference sequence. The
second
group of probes is designed by the same principles as described in the
Examples,
except that the probes exhibit complementarity to the second reference
sequence.
The inclusion of a second group (or further groups) can be particularly useful
for
analyzing short subsequences of the primary reference sequence in which
multiple
mutations are expected to occur within a short distance commensurate with the
length of the probes (e.g., two or more mutations within 9 to 21 bases).
3. Allele-Specific Primers
An allele-specific primer hybridizes to a site on target DNA overlapping a
polymorphism and only primes amplification of an allelic form to which the
primer
exhibits perfect complementarity. See Gibbs, Nucleic Acid Res. 17, 2427-2448
(1989). This primer is used in conjunction with a second primer which
hybridizes at
a distal site. Amplification proceeds from the two primers, resulting in a
detectable
product which indicates the particular allelic form is present. A control is
usually
performed with a second pair of primers, one of which shows a single base
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mismatch at the polymorphic site and the other of which exhibits perfect
complementarity to a distal site. The single-base mismatch prevents
amplification
and no detectable product is formed. The method works best when the mismatch
is
included in the 3'-most position of the oligonucleotide aligned with the
polymorphism because this position is most destabilizing to elongation from
the
primer (see, e.g., WO 93/22456).
4. Direct-Sequencing
The direct analysis of the sequence of polymorphisms of the present invention
can be accomplished using either the dideoxy chain termination method or the
Maxam Gilbert method (see Sambrook et al., Molecular Cloning, A Laboratory
Manual (2nd Ed., CSHP, New York 1989); Zyskind et al., Recombinant DNA
Laboratory Manual, (Acad. Press, 1988)).
5. Denaturing Gradient Gel Electrophoresis
Amplification products generated using the polymerase chain reaction can be
analyzed by the use of denaturing gradient gel electrophoresis. Different
alleles can
be identified based on the different sequence-dependent melting properties and
electrophoretic migration of DNA in solution. Erlich, ed., PCR Technology,
Principles and Applications for DNA Amplification, (W.H. Freeman and Co, New
York, 1992), Chapter 7.
6. Single-Strand Conformation Polymorphism Analysis
Alleles of target sequences can be differentiated using single-strand
conformation polymorphism analysis, which identifies base differences by
alteration
in electrophoretic migration of single stranded PCR products, as described in
Orita
et al., Proc. Nat. Acad. Sci. 86, 2766-2770 (1989). Amplified PCR products can
be
generated as described above, and~heated or otherwise denatured, to form
single
stranded amplification products. Single-stranded nucleic acids may refold or
form
secondary structures which are partially dependent on the base sequence. The
different electrophoretic mobilities of single-stranded amplification products
can be
related to base-sequence differences between alleles of target sequences.
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7. Single Base Extension
An alternative method for identifying and analyzing polymorphisms is based
on single-base extension (SBE) of a fluorescently-labeled primer coupled with
fluorescence resonance energy transfer (FRET) between the label of the added
base
and the label of the primer. Typically, the method, such as that described by
Chen et
al., (PNAS 94:10756-61 (1997), incorporated herein by reference) uses a locus-
specific oligonucleotide primer labeled on the 5' terminus with 5-
carboxyfluorescein
(FAM). This labeled primer is designed so that the 3' end is immediately
adjacent
to the polymorphic site of interest. The labeled primer is hybridized to the
locus,
and single base extension of the labeled primer is performed with
fluorescently
labeled dideoxyribonucleotides (ddNTPs) in dye-terminator sequencing fashion,
except that no deoxyribonucleotides are present. An increase in fluorescence
of the
added ddNTP in response to excitation at the wavelength of the labeled primer
is
used to infer the identity of the added nucleotide.
III. Methods of Use
After determining polymorphic forms) present in an individual at one or more
polymorphic sites, this information can be used in a number of methods.
A. Forensics
Determination of which polymorphic forms occupy a set of polymorphic sites
in an individual identifies a set of polymorphic forms that distinguishes the
individual. See generally National Research Council, The Evaluation of
Forensic
DNA Evidence (Eds. Pollard et al., National Academy Press, DC, 1996). The more
sites that are analyzed, the lower the probability that the set of polymorphic
forms in
one individual is the same as that in an unrelated individual. Preferably, if
multiple
sites are analyzed, the sites are unlinked. Thus, polymorphisms of the
invention are
often used in conjunction with polymorphisms in distal genes. Preferred
polymorphisms for use in forensics are biallelic because the population
frequencies
of two polymorphic forms can usually be determined with greater accuracy than
those of multiple polymorphic forms at multi-allelic loci.
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The capacity to identify a distinguishing or unique set of forensic markers in
an individual is useful for forensic analysis. For example, one can determine
whether a blood sample from a suspect matches a blood or other tissue sample
from
a crime scene by determining whether the set of polymorphic forms occupying
selected polymorphic sites is the same in the suspect and the sample. If the
set of
polymorphic markers does not match between a suspect and a sample, it can be
concluded (barring experimental error) that the suspect was not the source of
the
sample. If the set of markers does match, one can conclude that the DNA from
the
suspect is consistent with that found at the crime scene. If frequencies of
the
polymorphic forms at the loci tested have been determined (e.g., by analysis
of a
suitable population of individuals), one can perform a statistical analysis to
determine the probability that a match of suspect and crime scene sample would
occur by chance.
p(ID) is the probability that two random individuals have the same
polymorphic or allelic form at a given polymorphic site. In biallelic loci,
four
genotypes are possible: AA, AB, BA, and BB. If alleles A and B occur in a
haploid
genome of the organism with frequencies x and y, the probability of each
genotype
in a diploid organism is (see WO 95/12607):
Homozygote: p(AA)= x2
Homozygote: p(BB)= y2 = (1-x)z
Single Heterozygote: p(AB)= p(BA)= xy = x(1-x)
Both Heterozygotes: p(AB+BA)= 2xy = 2x(1-x)
The probability of identity at one locus (i.e, the probability that two
individuals, picked at random from a population will have identical
polymorphic
forms at a given locus) is given by the equation:
p(ID) _ (xz)Z + (2xy)2 + (~)Z.
These calculations can be extended for any number of polymorphic forms at a
given locus. For example, the probability of identity p(ID) for a 3-allele
system
where the alleles have the frequencies in the population of x, y and z,
respectively, is
equal to the sum of the squares of the genotype frequencies:
p(ID) = x4 + (2xy)2 + (2yz)Z + (2xz)Z + z4 + ya
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In a locus of n alleles, the appropriate binomial expansion is used to
calculate
p(ID) and p(exc).
The cumulative probability of identity (cum p(ID)) for each of multiple
unlinked loci is determined by multiplying the probabilities provided by each
locus.
S cum p(ID) = p(ID1)p(ID2)p(ID3).... p(IDn)
The cumulative probability of non-identity for n loci (i.e. the probability
that
two random individuals will be different at 1 or more loci) is given by the
equation:
cum p(nonID) = 1-cum p(ID).
If several polymorphic loci are tested, the cumulative probability of non-
identity for random individuals becomes very high (e.g., one billion to one).
Such
probabilities can be taken into account together with other evidence in
determining
the guilt or innocence of the suspect.
B. Paternity Testing
The object of paternity testing is usually to determine whether a male is the
father of a child. In most cases, the mother of the child is known and thus,
the
mother's contribution to the child's genotype can be traced. Paternity testing
investigates whether the part of the child's genotype not attributable to the
mother is
consistent with that of the putative father. Paternity testing can be
performed by
analyzing sets of polymorphisms in the putative father and the child.
If the set of polymorphisms in the child attributable to the father does not
match the set of polymorphisms of the putative father, it can be concluded,
barring
experimental error, that the putative father is not the real father. If the
set of
polymorphisms in the child attributable to the father does match the set of
polymorphisms of the putative father, a statistical calculation can be
performed to
determine the probability of coincidental match.
The probability of parentage exclusion (representing the probability that a
random male will have a polymorphic form at a given polymorphic site that
makes
him incompatible as the father) is given by the equation (see WO 95/12607):
p(exc) = xy(1-xy)
where x and y are the population frequencies of alleles A and B of a biallelic
polymorphic site.
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(At a triallelic site p(exc) = xy(1-xy) + yz(1- yz) + xz(1-xz)+ 3xyz(1-xyz))),
where x, y and z and the respective population frequencies of alleles A, B and
C).
The probability of non-exclusion is
p(non-exc) = 1-p(exc)
The cumulative probability of non-exclusion (representing the value obtained
when n loci are used) is thus:
cum p(non-exc) = p(non-excl)p(non-exc2)p(non-exc3).... p(non-excn)
The cumulative probability of exclusion for n loci (representing the
probability
that a random male will be excluded)
cum p(exc) = 1 - cum p(non-exc).
If several polymorphic loci are included in the analysis, the cumulative
probability of exclusion of a random male is very high. This probability can
be
taken into account in assessing the liability of a putative father whose
polymorphic
marker set matches the child's polymorphic marker set attributable to his/her
father.
C. Correlation of Polymorphisms with Phenotypic Traits
The polymorphisms of the invention may contribute to the phenotype of an
organism in different ways. Some polymorphisms occur within a protein coding
sequence and contribute to phenotype by affecting protein structure. The
effect may
be neutral, beneficial or detrimental, or both beneficial and detrimental,
depending
on the circumstances. For example, a heterozygous sickle cell mutation confers
,
resistance to malaria, but a homozygous sickle cell mutation is usually
lethal. Other
polymorphisms occur in noncoding regions but may exert phenotypic effects
indirectly via influence on replication, transcription, and translation. A
single
polymorphism may affect more than one phenotypic trait. Likewise, a single
phenotypic trait may be affected by polymorphisms in different genes. Further,
some polymorphisms predispose an individual to a distinct mutation that is
causally
related to a certain phenotype. For example, the polymorphisms identified
herein
and shown in Table 3 are present in the chromosomal loci which have been
identified as described herein as confernng susceptibility to IBD such as CD
and
UC.
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Correlation is performed for a population of individuals who have been tested
for the presence or absence of a phenotypic trait of interest and for
polymorphic
markers sets. To perform such analysis, the presence or absence of a set of
polymorphisms (i.e. a polymorphic set) is determined for a set of the
individuals,
some of whom exhibit a particular trait, and some of which exhibit lack of the
trait.
The alleles of each polymorphism of the set are then reviewed to determine
whether
the presence or absence of a particular allele is associated with the trait of
interest.
Correlation can be performed by standard statistical methods such as a K-
squared
test and statistically significant correlations between polymorphic forms) and
phenotypic characteristics are noted. For example, it might be found that the
presence of allele A1 at polymorphism A correlates with heart disease. As a
further
example, it might be found that the combined presence of allele Al at
polymorphism
A and allele B 1 at polymorphism B correlates with increased susceptibility to
IBD
(e.g., CD andUC).0
Such correlations can be exploited in several ways. In the case of a strong
correlation between a set of one or more polymorphic forms and a disease for
which
treatment is available, detection of the polymorphic form set in a human or
animal
patient may justify immediate administration of treatment, or at least the
institution
of regular monitoring of the patient. Detection of a polymorphic form
correlated
with serious disease in a couple contemplating a family may also be valuable
to the
couple in their reproductive decisions. For example, the female partner might
elect
to undergo in vitro fertilization to avoid the possibility of transmitting
such a
polymorphism from her husband to her offspring. In the case of a weaker, but
still
statistically significant correlation between a polymorphic set and human
disease,
immediate therapeutic intervention or monitoring may not be justified.
Nevertheless, the patient can be motivated to begin simple life-style changes
(e.g.,
diet, exercise) that can be accomplished at little cost to the patient but
confer
potential benefits in reducing the risk of conditions to which the patient may
have
increased susceptibility by virtue of variant alleles. Identification of a
polymorphic
set in a patient correlated with enhanced receptiveness to one of several
treatment
regimes for a disease indicates that this treatment regime should be followed.
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For animals and plants, correlations between characteristics and phenotype are
useful for breeding for desired characteristics. For example, Beitz et al., US
5,292,639 discuss use of bovine mitochondrial polymorphisms in a breeding
program to improve milk production in cows. To evaluate the effect of mtDNA D-
S loop sequence polymorphism on milk production, each cow was assigned a value
of
1 if variant or 0 if wildtype with respect to a prototypical mitochondrial DNA
sequence at each of 17 locations considered. Each production trait was
analyzed
individually with the following animal model:
Y;~kp~ ~.L + YS; + P~ + Xk + (3~ + ... (3,~ + PEn + an +ep
where Y;~k~P 1S the milk, fat, fat percentage, SNF, SNF percentage, energy
concentration, or lactation energy record; ~ is an overall mean; YS; is the
effect
common to all cows calving in year-season; Xk is the effect common to cows in
either the high or average selection line; ~3; to ~31~ are the binomial
regressions of
production record on mtDNA D-loop sequence polymorphisms; PE~ is permanent
environmental effect common to all records of cow n; a" is effect of animal n
and is
composed of the additive genetic contribution of sire and dam breeding values
and a
Mendelian sampling effect; and eP is a random residual. It was found that
eleven of
seventeen polymorphisms tested influenced at least one production trait.
Bovines
having the best polymorphic forms for milk production at these eleven loci are
used
as parents for breeding the next generation of the herd.
D. Genetic Mapping of Phenotypic Traits
The previous section concerns identifying correlations between phenotypic
traits (e.g., IBD) and polymorphisms that directly or indirectly contribute to
those
traits, such as those identified in Table 3. The present section describes
identification of a physical linkage between a genetic locus associated with a
trait of
interest and polymorphic markers that are not associated with the trait, but
are in
physical proximity with the genetic locus responsible for the trait and co-
segregate
with it. Such analysis is useful for mapping a genetic locus associated with a
phenotypic trait to a chromosomal position, and thereby cloning genes)
responsible
for the trait. See Lander et al., Proc. Natl. Acad. Sci. (USA) 83, 7353-7357
(1986);
Lander et al., Proc. Natl. Acad. Sci. (USA) 84, 2363-2367 (1987); Donis-Keller
et
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al., Cell 51, 319-337 (1987); Lander et al., Genetics 121, 185-199 (1989)).
Genes
localized by linkage can be cloned by a process known as directional cloning.
See
Wainwright, Med. J. Australia 159, 170-174 (1993); Collins, Nature Genetics 1,
3-6
(1992).
S Linkage studies are typically performed on members of a family. Available
members of the family are characterized for the presence or absence of a
phenotypic
trait and for a set of polymorphic markers. The distribution of polymorphic
markers
in an informative meiosis is then analyzed to determine which polymorphic
markers
co-segregate with a phenotypic trait. See, e.g., Kerem et al., Science 245,
1073-1080
(1989); Monaco et al., Nature 316, 842 (1985); Yamoka et al., Neurology 40,
222-
226 (1990); Rossiter et al., FASEB Journal S, 21-27 (1991).
Linkage is analyzed by calculation of LOD (log of the odds) values. A lod
value is the relative likelihood of obtaining observed segregation data for a
marker
and a genetic locus when the two are located at a recombination fraction 8,
versus
the situation in which the two are not linked, and thus segregating
independently
(Thompson & Thompson, Genetics in Medicine (5th ed, W.B. Saunders Company,
Philadelphia, 1991); Strachan, "Mapping the human genome" in The Human
Genome (BIOS Scientific Publishers Ltd, Oxford), Chapter 4). A series of
likelihood ratios are calculated at various recombination fractions (6),
ranging from
8 = 0.0 (coincident loci) to 8 = 0.50 (unlinked). Thus, the likelihood at a
given
value of 8 is: probability of data if loci linked at 8 to probability of data
if loci
unlinked. The computed likelihoods are usually expressed as the logo of this
ratio
(i.e., a lod score). For example, a lod score of 3 indicates 1000:1 odds
against an
apparent observed linkage being a coincidence. The use of logarithms allows
data
collected from different families to be combined by simple addition. Computer
programs are available for the calculation of lod scores for differing values
of 8
(e.g., LIPED, MLINK (Lathrop, Proc. Nat. Acad. Sci. (USA) 81, 3443-3446
(1984)).
For any particular lod score, a recombination fraction may be determined from
mathematical tables. See Smith et al., Mathematical tables for research
workers in
human genetics (Churchill, London, 1961); Smith, Ann. Hum. Genet. 32, 127-150
(1968). The value of 8 at which the lod score is the highest is considered to
be the
best estimate of the recombination fraction.
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Positive lod score values suggest that the two loci are linked, whereas
negative
values suggest that linkage is less likely (at that value of 8) than the
possibility that
the two loci are unlinked. By convention, a combined lod score of +3 or
greater
(equivalent to greater than 1000:1 odds in favor of linkage) is considered
definitive
evidence that two loci are linked. Similarly, by convention, a negative lod
score of -
2 or less is taken as definitive evidence against linkage of the two loci
being
compared. Negative linkage data are useful in excluding a chromosome or a
segment thereof from consideration. The search focuses on the remaining non-
excluded chromosomal locations.
IV. Modified Polypeptides and Gene Sequences
The invention further provides variant forms of nucleic acids and
corresponding proteins. The nucleic acids comprise one of the sequences
described
in Table 3, in which the polymorphic position is occupied by one of the
alternative
bases for that position. Some nucleic acids encode full-length variant forms
of
proteins. Similarly, variant proteins have the prototypical amino acid
sequences
encoded by nucleic acid sequences shown in Table 3, (read so as to be in-frame
with
the full-length coding sequence of which it is a component) except at an amino
acid
encoded by a codon including one of the polymorphic positions shown in Table
3.
That position is occupied by the amino acid coded by the corresponding codon
in
any of the alternative forms shown in Table 3.
Variant genes can be expressed in an expression vector in which a variant gene
is operably linked to a native or other promoter. Usually, the promoter is a
eukaryotic promoter for expression in a mammalian cell. The transcription
regulation sequences typically include a heterologous promoter and optionally
an
enhancer which is recognized by the host. The selection of an appropriate
promoter,
for example trp, lac, phage promoters, glycolytic enzyme promoters and tRNA
promoters, depends on the host selected. Commercially available expression
vectors
can be used. Vectors can include host-recognized replication systems,
amplifiable
genes, selectable markers, host sequences useful for insertion into the host
genome,
and the like.
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The means of introducing the expression construct into a host cell varies
depending upon the particular construction and the target host. Suitable means
include fusion, conjugation, transfection, transduction, electroporation or
injection,
as described in Sambrook, supra. A wide variety of host cells can be employed
for
expression of the variant gene, both prokaryotic and eukaryotic. Suitable host
cells
include bacteria such as E. coli, yeast, filamentous fungi, insect cells,
mammalian
cells, typically immortalized, e.g., mouse, CHO, human and monkey cell lines
and
derivatives thereof. Preferred host cells are able to process the variant gene
product
to produce an appropriate mature polypeptide. Processing includes
glycosylation,
ubiquitination, disulfide bond formation, general post-translational
modification, and
the like. As used herein, "gene product" includes mRNA, peptide and protein
products.
The protein may be isolated by conventional means of protein biochemistry
and purification to obtain a substantially pure product, i.e., 80, 95 or 99%
free of cell
component contaminants, as described in Jacoby, Methods in Enzymology Volume
104, Academic Press, New York (1984); Scopes, Protein Purification, Principles
and Practice, 2nd Edition, Springer-Verlag, New York (1987); and Deutscher
(ed),
Guide to Protein Purification, Methods in Enzymology, Vol. 182 (1990). If the
protein is secreted, it can be isolated from the supernatant in which the host
cell is
grown. If not secreted, the protein can be isolated from a lysate of the host
cells.
The invention further provides transgenic nonhuman animals capable of
expressing an exogenous variant gene and/or having one or both alleles of an
endogenous variant gene inactivated. Expression of an exogenous variant gene
is
usually achieved by operably linking the gene to a promoter and optionally an
enhancer, and microinjecting the construct into a zygote. See Hogan et al.,
"Manipulating the Mouse Embryo, A Laboratory Manual," Cold Spring Harbor
Laboratory. Inactivation of endogenous variant genes can be achieved by
forming a
transgene in which a cloned variant gene is inactivated by insertion of a
positive
selection marker. See Capecchi, Science 244, 1288-1292 (1989). The transgene
is
then introduced into an embryonic stem cell, where it undergoes homologous
recombination with an endogenous variant gene. Mice and other rodents are
preferred animals. Such animals provide useful drug screening systems.
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In addition to substantially full-length polypeptides expressed by variant
genes, the present invention includes biologically active fragments of the
polypeptides, or analogs thereof, including organic molecules which simulate
the
interactions of the peptides. Biologically active fragments include any
portion of the
S full-length polypeptide which confers a biological function on the variant
gene
product, including ligand binding, and antibody binding. Ligand binding
includes
binding by nucleic acids, proteins or polypeptides, small biologically active
molecules, or large cellular structures.
Polyclonal and/or monoclonal antibodies that specifically bind to variant gene
products but not to corresponding prototypical gene products are also
provided.
Antibodies can be made by injecting mice or other animals with the variant
gene
product or synthetic peptide fragments thereof. Monoclonal antibodies are
screened
as are described, for example, in Harlow & Lane, Antibodies, A Laboratory
Manual,
Cold Spring Harbor Press, New York (1988); Goding, Monoclonal antibodies,
Principles and Practice (2d ed.) Academic Press, New York (1986). Monoclonal
antibodies are tested for specific immunoreactivity with a variant gene
product and
lack of immunoreactivity to the corresponding prototypical gene product. These
antibodies are useful in diagnostic assays for detection of the variant form,
or as an
active ingredient in a pharmaceutical composition.
V. Kits
The invention further provides kits comprising at least one allele-specific
oligonucleotide as described herein. Often, the kits contain one or more pairs
of
allele-specific oligonucleotides hybridizing to different forms of a
polymorphism.
In some kits, the allele-specific oligonucleotides are provided immobilized to
a
substrate. For example, the same substrate can comprise allele-specific
oligonucleotide probes for detecting at least 10, 100 or all of the
polymorphisms
shown in Table 3. Optional additional components of the kit include, for
example,
restriction enzymes, reverse-transcriptase or polymerise, the substrate
nucleoside
triphosphates, means used to label (for example, an avidin-enzyme conjugate
and
enzyme substrate and chromogen if the label is biotin), and the appropriate
buffers
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for reverse transcription, PCR, or hybridization reactions. Usually, the kit
also
contains instructions for carrying out the methods.
The following Examples are offered for the purpose of illustrating the present
invention and are not to be construed to limit the scope of this invention.
The
teachings of all references cited herein are hereby incorporated herein by
reference.
EXAMPLES
With the goal of identifying IBD susceptibility genes, a genomewide scan was
undertaken in 163 pedigrees, and three regions of suggestive linkage (3, Sq31-
33,
6p) and one of significant linkage to 19p13 (LOD = 4.6) were identified.
Higher
density mapping in the suggestive Sq31-33 region revealed a CD susceptibility
locus
of genome-wide significance (LOD = 3.9). Importantly, the Sq31-p33 localizes
to
the major immunoregulatory cytokine gene cluster and the 19p13 locus to a
region
containing numerous genes encoding cytokine/chemokine receptors and other
inflammatory-associated molecules that could have a direct role in disease
susceptibility.
In order to pursue the evidence of linkage to chromosome 5, a systematic
linkage disequilibrium (LD) approach was adopted. The approach that was used
in
the first stage of LD mapping was to genotype all known microsatellite markers
in
the 18 cM between DSS1435 and DSS1480, as these two markers delimit a region
of
a 2 LOD drop on either side of the linkage peak centered at marker DSS2497.
All
alleles for each marker were examined for evidence of excess transmission from
heterozygous parents to CD child using the transmission disequilibrium test
(TDT).
Only alleles at two of the 57 markers had significant CZ results (p<0.001):
IRFIpl
(CZ=13.3, p=0.0003) and D5S1984 (CZ=14.0, p=0.0002) (Table 1). A second stage
of mapping was then undertaken to confirm, as well as to better delimit, the
region
of LD surrounding IRFlpland DSS1984. The development of new microsatellite
markers was necessary. The marker with the most significant Cz result was
CAhl7a
(Cz=16.2, p=0.00006) and was located between IRF 1 p 1 and DS S 1984 (Table
2).
Furthermore, the alleles 193, 156, 373, 140, 222, and 307 at markers GAhl8a,
IRFIp, CAhlSa, CAhl7a, DSS1984, CSF2p10, respectively, define ahaplotype
conferring susceptibility to Crohn's disease (CD). In order to identify the
sequence
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variant that would explain the genetic susceptibility to CD provided by this
haplotype, a search was performed for all single nucleotide polymorphisms
(SNPs)
in this region of LD. The SNP discovery was accomplished by direct sequencing
of
overlapping PCR products amplified from DNA samples from eight individuals
(six
S CD patients, one unaffected family member, and one CEPH DNA as control).
Table
3 shows the results of the SNP discovery analyses.
139 triads were genotyped for a total of 241 SNPs thus far, where at least 50
trios were fully genotyped. Using a CZ value of 13 (corresponding to a p-value
of
0.05) as threshold, 12 SNPs were found to have a significant level of
association
with CD and extended over a region of 250 kb, from IRF1 to prolyl4
hydroxylase.
These were markers IGR2055a 1, IGR2060a 1, IGR2063b-1, IGR2069a 2,
IGR2078a 1, IGR2096a l, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a l,
IGR3096a 1, PROLYLex3_1 (see Table 4). Any of these best SNPs by themselves
are in strong association with CD and fully explain the microsatellite LD
observations. Furthermore, the best SNPs have nearly identical association
characteristics (that is, the allele at one SNP determines the allele of all
others on
any phased chromosome), confirming that a single risk haplotype extending
approximately 250 kb is the source of all the observations of association in
this
region. Specifically, this haplotype is defined by the alleles G, C, G, T, A,
A, G, T,
G, G, C, T at markers IGR2055a-1, IGR2060a 1, IGR2063b-1, IGR2069a 2,
IGR2078a 1, IGR2096a 1, IGR2198a 1, IGR2230a 1, IGR2277a 1, IGR3081a 1,
IGR3096a 1, PROLYLex3-1, respectively. The frequency of this haplotype is
estimated to be approximately 37% in the general population. Furthermore, this
haplotype is transmitted from heterozygous parents to CD patients at a ratio
of 2.5:1.
Families
For the linkage study, multicase families with 2 or more siblings affected by
IBD were identified by review of clinical charts of all patients registered in
the
Mount Sinai Hospital Inflammatory Bowel Disease Unit patient database and from
the Hospital for Sick Children IBD database. Patients were also referred by
physicians in the Greater Toronto Area (GTA). To confirm and update
information
obtained from these records, all patients were sent a questionnaire inquiring
about
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the presence of a family history of IBD. Individuals identified as having
other
affected first-degree relatives were invited to participate and asked for
permission to
contact other affected and unaffected family members. Endoscopic, histological
and
radiological reports as well as clinical data were obtained on all affected
individuals
and these reports were reviewed for verification of diagnosis based upon
standard
. criteria. Venous blood sampling was performed on affected individuals and
their
parents, and DNA was extracted using a salting out procedure. Ethics approval
for
this study was given by the University of Toronto Ethics Committee and written
informed consent was obtained from all participants.
All of the LD analyses in this study were performed with father-mother-
affected child (CD only) triads, where 0 or 1 of the parents was affected with
CD.
These triads either came from the multicase families used in the linkage stage
of this
study or were identified specifically for the purpose of the LD study.
Specifically,
for the microsatellite genotyping, 296 triads were genotyped: 95 of these
triads were
derived from families used in the original identification of the IBDS locus
(only one
triad per family), and 201 were from newly collected families. For the SNP
genotyping, 139 triads were genotyped: 18 were derived from families used in
the
original identification of the IBDS locus, and 121 were from the newly
collected
families. Individuals affected by CD were identified by review of the clinical
charts
of all patients registered in the Mount Sinai Hospital Inflammatory Bowel
Disease
Centre patient database and from the Toronto Hospital for Sick Children IBD
database. Written informed consent was obtained from all participants and
ethics
approval for this study was granted by the University of Toronto Ethics
Committee.
Microsatellite Genotyping
Genomic DNA was extracted from peripheral blood lymphocytes from
probands and family members from 163 Caucasian pedigrees. The genome-wide
scan, with an average inter-marker spacing of 12 cM, was carried out using a
modified version of the Cooperative Human Linkage Centre (CHLC) Screening
Set/version 6.0 that also included Genethon markers. These 312 loci were
amplified
using fluorescently-labeled primers (Research Genetics Inc., Huntsville AL) in
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separate polymerase chain reactions, and the products were then multiplexed
into
panels by pooling before electrophoresis on ABI 377 sequencers (PE Applied
Biosystems, Foster City, CA). Fluorescent genotyping gels were analyzed in an
automated system developed at the Whitehead Institute/MIT Center for Genome
Research. Further details of the genotyping system have previously been
described
(Rioux et al., Gastroenterology 115:1062-1065 (1998)).
The region of suggestive linkage on chromosome 5 and the surrounding
regions of poor information content were followed up with 34 additional
microsatellite markers. Specifically, 34 markers were genotyped between
markers DSS1470 and DSS1471, decreasing the average spacing between markers
to approximately 3 cM in this 125 cM region. This higher density mapping was
performed on the original samples and on additional 12 families, for a total
of 175
pedigrees analyzed. These new families consisted of 16 CD affected sibpairs.
In the first phase of the microsatellite LD mapping, a total of 57
microsatellite
markers were genotyped on 296 CD triads. Information regarding primer
sequence,
allele size range, and suggested amplification conditions for 55 of these
genetic
markers (all but IRFlpI and CSF2p10) can be obtained from the Genethon
(http://www.genethon.fr/), Marshfield
(http://research.marshfieldclinic.org/genetics/), or Genome Database
(http://www.genethon.fr) World Wide Web sites. The markers IRFIpI, CSF2pl,
and the 8 markers used in the 2nd stage of LD mapping, were designed during
the
course of this study. Genotypes for all of these markers were obtained as
described
above.
SNP Discovery
In order to identify all SNPs in the IBDS critical region, a tiling path of
overlapping PCR roducts was designed. Specifically, PCR assays were designed
using Primer 3.0 to be approximately 700 by in length, with 100 by overlap
with
adjacent assays. The -21 M13 forward and the -28 M13 reverse sequences were
added to each of the forward and reverse PCR primers, respectively. These PCR
primers were used to amplify 50 ng of genomic DNA from six CD patients, one
unaffected family member, and one CEPH DNA as control. The PCR products were
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purified using the solid phase reversible immobilization (SPRI) method and
then
sequenced using the appropriate -21 M13 or -28 M13 DYEnamic Direct Cycle
Sequencing kit (Amersham Pharmacia Biotech Ltd, Cleveland, OH). All sequencing
reactions were run on ABI377 automated sequencers (PE Applied BioSystems,
Foster City, CA); the gel files were processed using the BASS software,
available on
the Whitehead Institute/MIT Center for Genome Research FTP site. Sequences
were base-called by the Phred program, and then the forward and reverse reads
were
assembled by the Phrap program. All traces were visually inspected by at least
two
observers.
SNP genotyping
SNP genotyping was performed using length-multiplexed single-base
extension (LM-SBE) as previously described. Briefly, PCR primers were designed
as close as possible to the SNPs identified in the current study, resulting in
a product
of a maximum length of 150 bp. Forward primers had T7 tails at their 5' ends
and
reverse primers had T3 tails at their 5' ends. These T7 and T3 tails were used
for
secondary amplification. Primer pairs were checked for homology to all
amplicons
and sorted into pools consisting of up to 50 primer pairs. Loci were subjected
to two
rounds of PCR amplification. In the first round, 10 ng of genomic DNA was
amplified using a pool of primer pairs (0.1 mM) and 2.5 units of Amplitaq Gold
(Perkin Elmer). In the second round, a 3 mL aliquot of the primary
amplification
product was amplified with biotinylated-T7 and biotinylated-T3 primers. A 7 mL
aliquot of this secondary amplification product was purified from the
unincorporated
dNTPs using streptavidin-coated Dynabeads (Dynal). A multiplex SBE reaction
was then carried out on the purified product using SNP-specific primers, JOE-
ddATP (0.12 M),TAMRA-ddCTP (0.12 M), FAM-ddGTP (0.12 M),ROX-ddUTP
(0.60 M; NEN DuPont) and Thermosequenase (0.5 U; Amersham). Excess ddNTPs
were removed from the SBE products using 96-well gel filtration blocks (Edge
Biosystems) prior to electrophoresis on ABI 377 sequencers. The SBE gels were
analyzed using a system developed at the Whitehead Institute/MIT Center for
Genome Research as previously described.
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Statistical analysis
Nonparametric multipoint linkage analysis of the data from the genome-wide
scan and the higher density mapping on chromosome 5 was performed using the
MAPMAKER/SIBS functions implemented in GENHUNTER 2Ø It is important to
note that all sib pairs from sibships with more than 2 affecteds were counted
but
were conservatively downweighted by a factor of 2/n (where n =the number of
affecteds). Exclusion mapping was also performed with this software package,
and a
locus 8s > 2 was considered excluded at a LOD score of -2.
To establish appropriate thresholds for suggestive and significant genome-
wide linkage for these particular datasets, simulations were performed by
generating
artificial genotype data with the identical family structures. These
simulations
matched the datasets with respect to marker density, marker informativeness,
the
individuals genotyped, affected status, and the fraction of missing data.
To assess the significance of the TDT results for each marker, permutation
tests using the same genotype data were carned out. For each trio, chromosomes
were randomly reassigned as transmitted or untransmitted to form a permuted
dataset. The number of permuted datasets with values as significant as that
seen for
the best single-marker and two-marker tests were tabulated. In order to
quantify the
extent of LD in the IBDS region, 3-marker haplotypes were examined using the
TDT
and Pexcess (d)~ Pexcess represents the strength of LD and is calculated by
(paffected - pnormal) / (1 - pnormal). In our study, the Paffected is
calculated from
the frequency of the haplotype among the transmitted parental chromosomes and
Pnormal is the frequency among untransmitted parental chromosomes.
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Table 1. Summary of the first stage of LD mapping using microsatellite
markers.
MarkerMarkerSourceEstimatedDistancePrevious TDT results
# Name o Geneticto nextlinks
a
markerPositionmarker results AlleleXZ pvalue
' MLOD
'
1 D5S1435G 128.50 0.50 0.76 115 5.84 0.016
$ 2 AFMa113G 129.00 0.83
e9
3 D5S1505M 129.83 0.00 0.79
4 D5S1384U 129.83 0.00
5 D5S471G 129.83 0.57 0.79 238 7.58 0.0059
6 D5S632G 130.40 0.20 114 4.59 0.032
1 7 D5S818M 130.60 0.20
~
8 D5S2502M 130.80 0.10
9 AFMB35G 130.90 0.04
2XH5
10 D5S1975G 130.94 0.00
11 D5S622G 130.94 1.86
1$ 12 D5S2059G 132.80 0.85 190 5.83 0.016
13 D5S615U 133.65 0.00 1.8
14 D5S804M 133.65 0.00 1.8
15 D5S1495M 133.65 0.00 1.8 382 4.00 0.045
16 GATA68M 133.65 0.35 2.2
A03
17 D5S809M 134.00 0.40 2.1
18 D5S2120G 134.40 0.20
19 D5S642G 134.60 0.65 2.6
20 D5S2057G 135.25 0.00 3.1
21 D5S2110G 135.25 0.62 3.1
2$ 22 IRF1 S 135.87 0.19 156 13.27 0.00027
1
23 D5S1984G 136.06 0.16 222 14.04 0.00018
24 CSF2 S 136.22 0.58 307 4.00 0.045
10
25 D5S2497G 136.80 0.10 3.9 129 7.69 0.0055
26 w2429/24G 136.90 0.10
owa7
27 w866/057G 137.00 0.10
v
5
28 D5S1766U 137.10 0.10 3.5 245 6.48 0.011
29 D5S808M 137.20 0.10 3.3
30 D5S458G 137.30 0.00 3.1
31 D5S396G 137.30 0.09
3$ 32 D5S2053G 137.39 0.56 3.0
33 D5S1995G 137.95 0.69 2.8
34 D5S2115G 138.64 0.68 2.4
35 IL9 M 139.32 0.01 2.0
36 D5S816M 139.33 0.07 2.0
37 D5S393G 139.40 0.10 2.0
38 D5S399G 139.50 0.90 2.0 127 4.57 0.032
39 D5S479G 140.40 0.10
40 AFM350yG 140.50 0.10
b1
41 D5S1983G 140.60 0.12 116 4.55 0.033
45 42 D5S476G 140.72 0.00 1.7
43 D5S500G 140.72 0.28 1.7 211 4.15 0.042
44 AFMB29G 141.00 0.82
OYC9
45 D5S414G 141.82 0.98
46 D5S2009G 142.80 0.12 140 6.70 0.01
$0 47 D5S658G 142.92 0.00 2.0
48 D5S2116G 142.92 1.08
49 D5S2011G 144.00 0.06
50 D5S2119G 144.06 0.00
51 D5S1979IG 144.06 1.15 I - - I - I
I 1 X I I
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52 D5S2017G 145.21 2.19 2.2 91 5.40 0.02
53 D5S2859M 147.40 0.09
54 D5S436G 147.49 0.00 1.6
55 D5S207M 147.49 0.00
56 D5S1480M 147.49 1.6
I 1 I I II I I I I
' Abbreviations: G, Genethon; M, Marshfield; U, Utah; S, designed by authors
from genomic sequence.
Z Estimated from genetic (Genethon, Marshfield) and physical (data not shown)
map information
' Linkage data for the CD subgroup with early onset disease as seen in figure
1 and reference ##I#
' Results are shown only if pvalue < 0.05
Table 2. Summary of combined LD mapping information.
MarkerMarker DistanceLD TDT results
# Name to next ma in
marker stage Allele T:U XZ pvalue
kb
57 CAh14b 43 2
58 ATTh14c167 2
59 IL4m2 164 2 214 1.8 4.74 0.029
60 GAh18a 21 2 193 1.4 0.018
22 IRF1 24 1 156 1.7 13.27 0.00027
1
61 CAh 130 2 373 1.5 7.73 0.0054
15a
62 CAh17a 97 2 140 1.8 16.19 0.00005
7
23 D5S1984163 1 222 1.8 14.04 0.00018
24 CSF2 178 1 307 1.4 4.00 0.045
10
63 CAh81 85 2
b
64 CAh81 2
c
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U V ~p7 U f0 m ~, V ~ O O (9~a7
0
O Q)V f0U~ U V O '-' ~ U V U ( f0O 0707~O
0
U 07 m ~ f0 (0 O ~ fC N ... f9(D(0~.O f0NU
... .... ....
M M M M
r-
C C C C
Y Y ~ Y
7 7 7 7
O N O N
L L
L L _~ _~
C C C C
N M CO M InCO00~ N M M N ~ f~ ~t M O
CO CON O N N 00~ ~ CO O O DO N ~ O O
~ M C' ~t~ ~ r-to ~ M M N CO d0 M N M
N ca N f0
C C C C
U U U U U U UU U U_ U U_ U_ U_ U U_ U
_ _ _
O O O O O O OO O O O O O O O O O N N N N
C C C C C C CC C C C C C C C C C C C C C
N O O N N N ON N O N N O O N N N O N N O
O m O O ~ ~ 0707 ~ O m O m O O7 O O O O O O
'O 'O'O 'a'O'Oa~ ~ 'p 'O 'O 'a~'''O ~ "'.D"''_O 'p
N N O N N O N O N N N O O N O
O ~N N ~.NN N OO ~ ,~>,.~>..~>,.~>,.~>,.~>..~>,.~>..~ ~ ~ :~_
-
_ 4-~ ~r_.w w 4=~ ~O w v-O ~ .f-O ~ O~ O .r-O.= .~ w .
4- ~ . ~ . .~ ~ ~ ~ ~ ~ ~ ~ . N
O O~ ~ O~ ~ y ~~ O ~ ~ O ~ ~ O~ ~ ~ ~ ~ O N
~ Z Z Z Z Z Z Z Z Z Z Z > >
Z > > > > > >> > > > > > > > > > > >
>
Q
~ a
_ _ O
O O
Q d Q
3 3 3
U N +N + U ~ ~ O ~+ 07 ~ = W
U
O O f0 fB(0~ ~(a (0 ~ t L ~ f0 f6 f~L f~ (0 (9
O O O
~ N ~ r-N M ~~ ~ ~ N ~ c- N ~ r-
I I I I I I I I I
I I I I I I II ~ f0 (9 (0 (0 (0 f0 f0 (a O O O O
~ tnf~ ~ M M LOM O O O O O O O O ~ '~h I~
N I~ f~ O)
M M M ~ lOt17~CO O N N CO ~ ~ lO CO (D
M M ~ (D (O CO CD
Q'
C~ C_~C~ C~C_~C_~C_~C_~ C_~ C_~ C~ C~ C~ C~ C~ C~ CJ J J J J
O
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-82-
N m a7 U f0 ~ a7
p O p ~ p O m ~ U U ~ (0
V U U N V Z f9 Z Z ~ U
Z U U ~U, (0 ~ U V ~ Z V Z
Uma7zp07pfp4fU9~U ~mw V U U
p ~ ~ ~ ~ ~ (0 (9 U U O U ~ Z_ N
~ _~ U ~ ~ p ~ U U U~ ~ ~ U ... U ~ p
O p U (4 " U ~ U N ~ V a7 O ~ ~ p) ~ 07
N U ~ f0 V U ~ U ~ U (0 U ~p U fp U ~ _U
V U N U ~ N ~ ~ ~ ~ ~ ~ O ~ U ~ U U p ~ U
U ~ (B U ~ (~ U f9 U (B p N "'' ~. O U ~ ~ C ~ ~ ~ U
~ O) p p7 f0 U ~ U (D U U ~ N U a7 a7 ~U.. U C ~ ~ U O
U fU0 ~ O ~ ~ O ~ p~ f0 V U U ~ ~ (0 ~ C f0 ~ N
p ~ U O) p p _ "'' ~ a7 f0 U ~ p7 V ~~.. ~ N U p
(9 U f~ _ .... 07 U O .-. p) I~ .'' p) .-. ~ (0
U O U w ~ ~ (0 ~ ~ a7 ~ U N ~ ~ U (9 O ~ ~ U N O p ~ ~ (0 N
U p ~ f0 Q7 U U O U ~ ~. p
U a7 ~ (0 (0 p O ~. O (9 O (d f0 U (0 m ~ (B O N ~ U U V 07 ~ ~ ~ t0 (9
V Q7 U N ~0 O 07 (a ~ ~0 ~ f0 m ~ (0 U O O O) U w U p p~ ~. ~ (a
O (9 U f0 O
N 07 ~ U U ~ V N fp0 p p ~ ~ f0 ~ U~ W ~ ~ 07 ~ f0 V ~ ~ N ~ ~ ~' O
U (p0 ~ U' U m ~ (0 ~ N ~ ~ U U U f9 fB U (U0 f0 O U ~ ~ a7 ~ (p0
U U ... (U (0 O ~. ~ ~. 01 ~ (0 ~ O U U I9 f0 U U V m ~ ~ ~ O) ~. m U
_O O O O O O O O O
M ~f ~ lO ~ O ~ O (9 (0 f~0 ~ (~ (~0 (6 O
C C C C C C C C~~~~~~~~~~~~~~~~rt~~Uf~O~Nr
7 7 ~ > > 7~LL'L~L~L~L~L~L~U~NU
OOOOOOO~U_O~-U_O
N O N O O O N N C V C V C U C U C U C U C U O ~C N N C V~l
L. W '- W W L W ~ O (0 O f0 O (p O (B O N O (0 O (0
p N N ~ ~ ~ ~ ~ L ~ L ~ L y- L y-. L ~ L aH L y~ C_ p C C p C
c c c c c c c _c ~ 't '~t '~C '~ '~t ~ " N = ~ cv
N N O O O N N ~L ~ " L ~ L
C C C C C C C V U
(a (6 (B f0 (0 (0 N N N N N N (0 fB f~ N f0
w w ~ ~ w w w ~ w w w ~ w w w
C C C C C C C C C C C C C C C C C
N O O U7 N O O N N O O N O O O O O
C C C C C C C C C C C C C C C C C
N O N N O O O N p N N O N N N N N
~ O O ~ ~ m O ~ ~ O m 07 ~ ~ m m 07
O -O 'O 'O 'O 'p -O 'O 'p '~ 'fl 'O 'a 'O 'O 'O 'O
N ~ N N ~ N O O N N N O N N O N O
:=. :~ := :- w :- ~ 'v= w- :~ ~ ~ :C 'v=. :C w :
L L L ~L L ~L ~L ~L ~L ~L ~L L L ~L W ~L ~L
v W W v ~ ~ W W v W U m ~ ~ U ~ v
U U U U ~p ~p U U p7 U ~ ~ ~ ~p .~ (p p7
r
O N I
O ~' r- I ~ N ~ X
I °~ cfl co ~n ~n ~I ~ ~I ~I NI ~I r-I
~ 00 00 O
~ X ~Iv~~(00C00 ~ Q~~~ O O ~ Z
I G~ a a I I I I ~ ~ ~ ~ ~ ~ °-
J_ J_ J_ J ~ ~ ~ ~ ~ ~' Q' ~ Q' ~ ~ O O
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-83-
o~ ~ ~ a> co
(0 U U U
U ~ ~ _ (0 U p N
U
( N
m 0 ~ U U 07 f0 N
07
: f0 U Z p ~ V
~ U U
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Z m Z o> ~ ~
cp a W ' z ~
cv Z rn cv
~ V U U C f0 U f0
9 f
~
(9 . Z .. r N f0
. ~ U .. ~ ~ ~ O )
. V
U
U V ~ ~ O
f0 V U ~ N m ~ (U
~ N ~
V Ip p~ O) V U U
~ U 07 ~ ~ p
f6 ~ U V U ~ U ) f0
U (0
U
~ ~ ~ V (0U U ~ N ~ p N V N
07 0 w' ~ U
~ m ~ p~ p~ U 07 ... O)
07 ..-. (0 ~ U f0 ~p ~ ~ Q)~ ~ (6
f0
~ U
O) U ~ V ~ U O) ~ (gyp_p7 ~ ~
~
(~0 ~ ~ (d V U U ~ w m ~ ~ ~ U ~ V O ~ _
U ~
p
p U U ~ (0 m O) a7 ~ (0 U ~ U (0 U
~ ~ V O ~
U f~U ~ ~ U ~ U O U U U V (0 U (~
O) ~ ~ p ~
U ~ O) ~ ~ U w U f0 " ' U f0 U U fB + U
~ , ~ U
~
~ ~ U U ~ O)~ f0~ ~ a7U fd~ f0fC ~
f9 f0 U
L L L L L L L L L L L L
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
C C C C C C C C C C C C
O O O O ~O O OO ~ OO N OO N O O O O NO O NO O N OO N OO
~ r- N N
a . ~ a . a. Q o_. a n . ~Q . Q, ~ a. n..
~ L ~ L L L L L
L N ~ N ~ N~ N~ N~ L N ~ ~ ~ L~ ~ N ~ L N~ N~
N N L N N N N N O N N L
N O
C U C U ~C U CU ~ CU ~ CU ~ C U C U ~C U ~C U ~ CU ~ CU
~ ~ ~ N (0
(6UO N U O(BU0 fBU O (0U O f0U O f0UO fBV Of9U O(0U O ,~L,,U O ~UO
~L, L . L . L. ~. L. ~L,. L . ~L,. ~L.
.r ~. ... ~, ..,
.~ ~ a ~ ~ a ~ Q ~ Q ~ G a ~ a ~ a
Q N Q O N G1 N a O O N N O cnNtn
N ~ N ~ t4C ~ C~ fnCO fpCp fnC p C p VlC ~p!nC ~ C C~pC C~
fn fn C fn C C C
C
C C C ~ C C m C C~C - ~ m ~ m ~ O) 07
w O) !-'L N- ~ !-'L (d~'L N !rL ID!-'L ~ L N!-'L N- L IO!-'L CC!-'L
WD L (~
~
O~ ~ O wC O.L.~O ~ ~O ~ ~O r C O~L.. ~ O ~~ O ,YC O .~~O ~.L.~O
L L ~ L L~ Lv L~ L ~ L L ~ 'L~ Lv Lv
U U U U U U U U U U U U
f6 (9 N (0 N f0 N (B N N N (d
C C C C C C C C C C C C
p p N O N O O N N O N N
C C C C C C C C C C C C
N N N O N O O O O N N N
07 ~ a7 ~ Q7 ~ ~ m ~ O)
N O N O N O O O O N N N
w
' ' ' ' ~ ~ ~ ~ ~ ~
L L L L L L L L L L L L
~ U
(a N N fd
+~ ~
N .- ~ ~ N ~ N ~ N
I I I I I I
I I I I I I M ~i' ~ CC CO 1~
M CO CD O) ~ M X X X X X X
X X X
X X X N N N N N O N N O
N O O
r- .- ~ ~ N N N N N N N N
Z Z Z Z Z Z Z Z Z Z Z Z
H H H H H H H E- F- I- H H
U U U U U U U U U U U U
O O O O O O O O O O O O
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-84-
o~
m
O U~ V
f6(~~ U
U
~
Z O t0(~ ,
07 O ~ ~ ~~ ~ O
(6 O)
N Q7
O) O ~ O ~.,O ~ O
O ~ O ~ ~ (0~ O~ N ~f0
U O N ... O NN
~
."'. f0 f9(~ V IBOU O (0N 07U
U U O ~ (0 U Z Vf0Z w U
~
U ~ ~ Z OO
N
Q7 (d (0( U Z f9Z O U
~ (0 O fB0 U O U 07
(0
~ ~ ~ U ~ N (6(0~ N O' Z ~~
~ ~ ~ Zca
a7 U ~ ~ ~ Z V f0ca~~ U ZZ Q7~pV
~u U f0
O _ U ~ U ~ U O
" ~ f9
O) O ~ Z U U U U U~ U UU
m ~ ~ U U O
<O N ~ ~ f6U f ~ +~ NV,w
V O 9 .~ O ..
U U ~ a7O 07~ m ~(B~ O) ~07
O U U U ~ O mO N (B
~ _ ~ ~ N f0 ~ ~ (Df0~ f0_U U U
U N 07 f0
U ~ '-'U O ~ ~ U N f0~ ~ OU U(0
U U U ~ 0 U ~ a7 f0m~ ~ UU
Uf0
O) . (6... ( . ~.
O .
O O
(n N C
(9 N O
7 , 7,
Y YY Y Ya
O 0 0 0 0 O O O OY '
~ ~C C CC C C~
L
O
a ~ ~ ~ 0 ~ ~ 0 ~~ :~+..:-. - -C
~ d' O O OO O O
(l~(n(l~(n (n(n
> , ~,
_ _ U
O O
L L
d a.
f0 (B(6 (a(9 N N f0(0(6(~(0f0 (B(6N
C C C C C C C C CC C CC C CC
N N N O O N N N NN O OO O NO
C C C C C C C C CC C CC C CC
N O O N N N N N OO N NN O NO
O m Q) 07O Q)a7O)OO O OO m Q)O
O
N N O N O O O N OO O OO N NN
' ~''
w.~ :=:_~ w v-w w~ w ~_:~_ w.~_:C
~L ~L~L ~LL ~L~L~L~L~L~LL~L 'LL~L
U f0~. O
N
N d ~ d
~
N N
C ~ .C V
3 ~ 3
~ j ~ Nt ~ Nt j ~ N~ ~ ~O ~ ~U
H N N N f~ O
C ,C ~ ~
O O
N M I
I I I
I I I N ~ N ~~ v ~~I I I
CD COCO N I I IO O OO
I l N N N ~ ~ ~ ~X X __ X XN
~ ~ N XX
c,.) c0 c
O O OO O Op
X X O O O O O O ON ~ ~~ ~ ~I
N N <n lf7lf~ ~ ~ ~ l(7
7 . W p 'O'O 'aO ~ 'Od d dQ Q a.
0 o m cacu cocvm m u~ a~a~U
a d ~ ~ ~ ~ ~ ~ ~~ ~ ~~ ~ ~H
~ ~ ~
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-85-
Table 4. Summary of best SNPs in chromosome 5 region.
SNP ApproximSNP TranFrequenTrans UntraC' p-value
markerate type smittcy muted nsmitt
of
name Physical ed allele ed
2
position allel
'
a
IGR2055435.0 G/T G 0.357 87 39 18.290.000019
a 1
IGR2060437.5 C/G C 0.351 81 34 19.210.000012
a 1
IGR2063439.0 C/G G 0.359 87 37 20.160.000007
b 1
IGR2069442.0 C/T T 0.627 52 20 14.220.00016
a2
IGR2078446.5 A/G A 0.364 48 16 16.000.000063
al
IGR2096455.5 A/C A 0.349 75 32 17.280.000032
al
IGR2198506.5 C/G G 0.364 87 41 16.530.000048
a 1
IGR2230522.5 C/T T 0.415 67 28 16.010.000063
a 1
IGR2277546.0 A/G G 0.417 79 37 15.210.000096
a 1
IGR3081609.0 G/T G 0.338 79 35 16.980.000038
al
IGR3096616.5 C/T C 0.429 89 42 16.860.00004
al
PROLY 686.5 G/T T 0.383 79 39 13.560.00023
Lex3
1
' Position (kb) on the 850 kb reference sequence.
z Frequency of allele calculated from the untransmitted parental chromosomes.
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
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TABLE S
>IGR2001 a
ggcccgaaaggactgtgccccctccccgtcaaacaccccccccccgcgtcccccaccaag
ttctggccggggctgtggagcgtgggtcacctgggggcgaaggactccacatcacggtga
agtggaggtgctgcagcccccacaaagcccgagaagcctgccaggggcgccccgggcgaa
cggcagtgggcgtgggccgttctgcagcacccattggcgcgggggaggagagtgctgatc
ccatcaagccccgctccaggtcgcggccgctgggcctggcccaggagcctcccccggcct
cggggccccatgggactgacagggggctgagttctctttcctcccaacggcggtgtttat
aagaaatgaagctccgcagcggccatcagcggcagcccacactgtcaccccgccccgctc
tcagggggttccggaacagccctgagcactggagcaattccttggctcagtattctatca
tgaccccctagtgattttccagccagcttcagccccacattctgcatttaggaattttat
aacagtgcaacgtttattctgctgtgtcatacagcatattttgccaaacctttgagaggg
gaggggctggtctggtgccccagtgtatctccagaaccaaacctggggttcaccaaaaag
caggcctgcgtgattcatatgtgttgaatgaattaaggga
>IGR2002a
cagccagcttcagccccacattctgcatttaggaattttataacagtgcaacgtttattc
tgctgtgtcatacagcatattttgccaaacctttgagaggggaggggctggtctggtgcc
ccagtgtatctccagaaccaaacctggggttcaccaaaaagcaggcctgcgtgattcata
tgtgttgaatgaattaagggactttctttctctccagttaggctccttgcaggcagggtg
atgacccttggattctgccttcaagcttttggatgcttttatttctggcttgtgttctgc
aattcacagtttaggactgcctgcctcccaggtttctgtgaaaatcgagatgaaggattt
gagcatttcagagagccctactacttctggacctggaacctggaaggcatgctggggagt
ttgtctgctttggggaccgtggccccctctctgggtagcaggctccacaggtagcaggtc
tcccagtcgaaaacctagttcaggtcgggcgccgtggctcatgcctataatcccagcact
ttgggaggccgaggcggtggatcacctgaggtcaggagttggagaacagcctggccaatg
tggtgaaactccatctccaccaaaaatacaaaaattagctgggcatggtggcgggtgcct
gtaatcccagctacttgggaggctgaggcaggagaattgc
>IGR2003 a
tcaggtcgggcgccgtggctcatgcctataatcccagcactttgggaggccgaggcggtg
gatcacctgaggtcaggagttggagaacagcctggccaatgtggtgaaactccatctcca
ccaaaaatacaaaaattagctgggcatggtggcgggtgcctgtaatcccagctacttggg
aggctgaggcaggagaattgctgaacccctggaggtagaggttgcagtgagccgagatca
cgtcactgcactccagcctgggtgacagagcgagactccgtctcaaaaaaacaaaacaaa
aaaacacctagtttaaacctcactggcacctgcacctcagctctcacaaactctcatttc
tgagcacacactcatctctatcagcagaggatttaaccacaggttgccaagaaatgtctg
tatctgagagaattcataatctgagatagaaggaacactaaactccagaggaagaggggt
cacacatcaacttaactaggatttactgagtgcctaccatggtagccactcttcggggga
gtgcaaggatggcggcatcaccttagtgtggtccgtgtggccctgtgcattgatgtgtgt
gtgcatggtgacatgttgggagccatgcttctgggcttcaggactaactgcagcccactt
agggggtgaacagtgttttgagagcctgagggaggggact
>IGR2004a
gatttactgagtgcctaccatggtagccactcttcgggggagtgcaaggatggcggcatc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
_87_
accttagtgtggtccgtgtggccctgtgcattgatgtgtgtgtgcatggtgacatgttgg
gagccatgcttctgggcttcaggactaactgcagcccacttagggggtgaacagtgtttt
gagagcctgagggaggggactggggacaagaattgtctgtcagggtagaggctcccacag
ggtgtgtgaatgtgtgtgtgagatgatcttgccttcagcatcctgattgcagaagtcact
tcaaaggagcccctgccagccagttagcctcctcttgccagcacagaaaaatccaggtcc
caatacagagaggccacacaatgaattcaccctcattgagtgaggctatggatgagaggc
atctgtaaggaagaccttgcacagtgcagggtgctggctaccctcagctaacccctagct
cgcttcagctgctgggcatgaggaacctgcttagatttctcacagaaaacatggagagtt
ctttttctcacagaaaaaatgtagagtttgttccccagagtttgttcccaccatgtagaa
agtgaccagtggtgaaaaggaaacataggaaagttaaggaccaaagggtccaaggaggga
aaagaaaggacttctggttggttgctttgcgggcattttg
>IGR2005 a
gaggaacctgcttagatttctcacagaaaacatggagagttctttttctcacagaaaaaa
tgtagagtttgttccccagagtttgttcccaccatgtagaaagtgaccagtggtgaaaag
gaaacataggaaagttaaggaccaaagggtccaaggagggaaaagaaaggacttctggtt
ggttgctttgcgggcattttgaagagatcaggcatatgctctgggccttaaaaaaagaca
cagagattgaagtggtggggtgggcaagggagagagagatggagagagggtgagtgttgc
caagtatcctgaggagacagggatgaggggacaaacacattgtgttcagataatggaaat
acagtgaaaggttcatgcgttcctgttcatacatttcatttgacttatgtcttacagttt
ggaaataattttgatagtctaattttacaattaggagagatggagagagattatctctat
tttacagatgagaaaactgagccccagagagggacagtaacttgctaagatcacatagca
agtggaaaaagcacaataagaacccaggctttcagactcaaatcctgtgttctcttttca
tccccctttagtttcatctttcctactgccaagggtagggaagctgtcagggacagaagg
ttggaatgggaccccaggacaagactgagcagagatttga
>IGR2006a
agccccagagagggacagtaacttgctaagatcacatagcaagtggaaaaagcacaataa
gaacccaggctttcagactcaaatcctgtgttctcttttcatccccctttagtttcatct
ttcctactgccaagggtagggaagctgtcagggacagaaggttggaatgggaccccagga
caagactgagcagagatttgaatgtggggctgaatgtaggggagctcagaaggctcctgg
gtggccccgagtgttagggagatcatccgagttagggagatcattccagtgcagaggcac
catcttccccatctacctgggcaaggcaaggaggcccaaggggaggttggggcaacaata
gtctggtcctggactatgaaatcacaacccgatacagggaaggaagacccagaagaccag
gtgggaaagaaaagggctggctccgaattaataagagcctacaggagcctatgtgttctg
ctggggatcacagaatgttctacatcttagaatgtgattcatcaaaagccattacaataa
aaatgttgggtacttaaacatggcttagctttatttcactgatttggagtatagcacccc
tagtcataataagcatattcttacaggcttcaaaataaagtaagaatccctaaggttaaa
aaaaaaaaaaaggtcaaagatgtaaatgtaaatgacagtt
>IGR2007a
ctacatcttagaatgtgattcatcaaaagccattacaataaaaatgttgggtacttaaac
atggcttagctttatttcactgatttggagtatagcacccctagtcataataagcatatt
cttacaggcttcaaaataaagtaagaatccctaaggttaaaaaaaaaaaaaaggtcaaag
atgtaaatgtaaatgacagtttcattggtaaatcctaactggggaatttctcctaagcaa
aaaattattgatatgcacaaagatttagctaatagtgttgtttgtattacgaaaaaatgg
aaataacctaactgtcctacaataggggattaattgggtaaatttttatttatccttgtg
aaagaataatgtatacctattacaaatgacattgcataagtacatttcatgacatggaaa
CA 02394033 2002-06-10
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_88_
gatgctcattatggctaaatatacatatgcatatacgggtatatttatacctgtatctgt
gaattaaaattaagtttttgttttaaagcattttttatagtgtcctgttgccttcacagg
gtcactgtggtcaacttatcagaccacaaagatgcaaacttcctttccctaatctcatcc
tgaattttccagtggatgtgtcaggttctcaggggaaggacaagcatctatttgctgtac
caagaaaggatcccacgactcaggggtcacttgttttctc
>IGR2008a
gttttaaagcattttttatagtgtcctgttgccttcacagggtcactgtggtcaacttat
cagaccacaaagatgcaaacttcctttccctaatctcatcctgaattttccagtggatgt
gtcaggttctcaggggaaggacaagcatctatttgctgtaccaagaaaggatcccacgac
tcaggggtcacttgttttctcttattcttgctcagaaggtcttggtccctgtagcaagtc
cccacttccatttgtcacttaaagtaccccaaaacccacctttccattccagagtgtcat
tgccctccactttgcttaacactcagttaggttccttcctcagtttctcctacctccttt
cctctcctagctcctgacccacctctatctggtagacagttttgcccattcctgctggta
tcctgggaaccaggtttggcattggtcacagcactcagattgcaatgcgccagaatggga
ttaacccatgcatttcctctacgggagggaggtagagtgactggcaagtcgaatgttgca
tgggtgtgtctatttatagcctgcaaaatggggtgctgccctggagggagagctgcggtg
aaggaaatgacacgcctgggagagtaacttacttctgcaggagctctagggagatgaagg
aagaagcctcctgggccagagttttggatggaaaatgaac
>IGR2009a
tacgggagggaggtagagtgactggcaagtcgaatgttgcatgggtgtgtctatttatag
cctgcaaaatggggtgctgccctggagggagagctgcggtgaaggaaatgacacgcctgg
gagagtaacttacttctgcaggagctctagggagatgaaggaagaagcctcctgggccag
agttttggatggaaaatgaacacccagtcaagtctctaggactatacgtggggcggggac
tagttgtgcgcgagagttaagtaggggcccttaccaaggagcatgggacctgggctcccc
aaccctttggctagccccatggcgttgatcagccctgagctaattcctccatgctgccca
gaacctctctgggccaagccctggggactcagagatgacagcaatgcttccattgcggaa
ctcccatacgcgggccacagggaggctctggaggcggcctgaggcaagagtgctaggagg
gatcagagctagcccacccctaccctcactcagccgtctgggcttctctgaaccccttct
cctcctctgttccctaaagccagccagggggagtcccagggaggcagaccgaaaaggggt
ggggtgtcatcctggtcactattagaccctgcaacggcgaccttgaaaactactcagcgt
ctgttgcccgagtggagcatagtgctttacaatctcttcc
>IGR201 Oa
ctaccctcactcagccgtctgggcttctctgaaccccttctcctcctctgttccctaaag
ccagccagggggagtcccagggaggcagaccgaaaaggggtggggtgtcatcctggtcac
tattagaccctgcaacggcgaccttgaaaactactcagcgtctgttgcccgagtggagca
tagtgctttacaatctcttcccatcacagcaaaccatcaaggtagggctactgttatttt
atggttgaaaaacagaggtcctgcgtcccttgggggctgtgccagcagcggccaagttgg
gatttcccctggtccagcagccccagacagcacacggggcagggtaggctttctgcctcc
ttcacttccccagggcaggtgagtgacctggagggagggggtcacccctaaaaacagggg
tagtgctaggactgaaaccctcccttcttgatatcccactggcaagcttgaggagccagg
ctgccagtcgggagattcggcccagtgttcccactggagagggcggcaagtgcccgggcg
atcacctcgcctgcgttcgggagatatacctccgcccccgccccgccaggagggtgaaaa
gatggccccaggagccagccggctgggacaaggcggagtgagaggacaggctggggccgg
gggcgctgggctgtcccgggcagccctcctccgggcaagc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-89-
>IGR2011 a
gcccagtgttcccactggagagggcggcaagtgcccgggcgatcacctcgcctgcgttcg
ggagatatacctccgcccccgccccgccaggagggtgaaaagatggccccaggagccagc
cggctgggacaaggcggagtgagaggacaggctggggccgggggcgctgggctgtcccgg
gcagccctcctccgggcaagccggagcaggggtggattgggagcgctcggggcgggcccg
cggtggccccggggcggtggcgcccggccggagagggtggggcggagcagccgccctgta
cttccccttcgccgctagctctacaacagcctgatttccccgaaatgacggcacgcagcc
ggccaatgggcgcccgcgcggctgtccgggggcggggccggccagggctggggaatcccg
ctaagtgtttggattgctcggtggcgccgctgccctggcagagctcgccactccttagtc
gaggcaagacgtgcgcccgagccccgccgaaccgaggccacccggagccgtgcccagtcc
acgccggccgtgcccggcggccttaagaacccggcaacctctgccttcttccctcttcca
ctcggagtcgcgctccgcgcgccctcactgcagcccctgcgtcgccgggaccctcgcgcg
cgaccgccgaatcgctcctgcagcagaggtgagtacgcct
>IGR2012a
agccccgccgaaccgaggccacccggagccgtgcccagtccacgccggccgtgcccggcg
gccttaagaacccggcaacctctgccttcttccctcttccactcggagtcgcgctccgcg
cgccctcactgcagcccctgcgtcgccgggaccctcgcgcgcgaccgccgaatcgctcct
gcagcagaggtgagtacgcctttgaggcgcggggcaccggcggcgtcgaataaaaggcgc
gcggggcaccaggaagtggggggtcgaaagctccaggctggagactcgccggcgcgcggc
gttgcccgggcctccgcgcgggctccggggggcgccggaggagctgcgagccgcgggccg
cggcgcggggagggcgggacgcggcgtggaccgcccacccggacgaggctgccggcgccc
ggcagctttcgcagatctgcgtgcgcgcagccgccaggggcctgtaggtggcccgctatg
ttcgtcccgcgcatccacacgccgtgccggggaccgagtgtcagcccacgcgtgggcgcc
cagtgctcccggctttcggcggtcccagctccgcgcccaggcgacaggttttgggctccc
tgtgctggtggcaagggctggcttactgcccaggtggctggagggaatcgtgacctacgg
agactgcgggaagaggcgccacaggtgttccttgggccac
>IGR2013a
cgccgtgccggggaccgagtgtcagcccacgcgtgggcgcccagtgctcccggctttcgg
cggtcccagctccgcgcccaggcgacaggttttgggctccctgtgctggtggcaagggct
ggcttactgcccaggtggctggagggaatcgtgacctacggagactgcgggaagaggcgc
cacaggtgttccttgggccacttctccagaggaggggaaaccgggccggaagggttagcg
tcctggtcttagcgttgtgggcgctgtggctgtcaggaaggcgtagaatggattcagggg
ggcgggagggggctgttcagggtgacggctagccctttgctagctagtggttacaactca
agtcaagggaatttcttcttggcatcaagcaaaagaagtccctcccttcccaaaggattt
gaattttgagcgaaaagttctgaaattagggtatctgtgcattttgtctcttttcctgca
tatgaatcctgaagccatcacttgcatgcctgtctcctccagagactggctgggaggggc
tgaaggaaggggcaaaagcatttttgcctaagatgctgaaaaaatttggagagcagtttt
attccagcgcagctcccctccgcactgagtgtagtacctagcagctggctgaggtgaggg
gagggtaactaagtgacctcgggtggggcaggtcactgcc
>IGR2014a
acttgcatgcctgtctcctccagagactggctgggaggggctgaaggaaggggcaaaagc
atttttgcctaagatgctgaaaaaatttggagagcagttttattccagcgcagctcccct
ccgcactgagtgtagtacctagcagctggctgaggtgaggggagggtaactaagtgacct
cgggtggggcaggtcactgcccaggtactgttcaacagattccagactggagcctctgtg
ttctctttacagccaacatgcccatcactcggatgcgcatgagaccctggctagagatgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-90-
agattaattccaaccaaatcccggggctcatctggattaataaagtgagtgtaactcttt
gggttttcctgccactgttttaacccatgtacttctggagggaccaaagcttcagatgca
gctcaaaaagggaagtgataacgggacaagcaggtgtttctcccagtgggtcctgcatgc
agggagtgtgcacggcccagcctgggcctcacttgcatgactcctgccttcttcccttct
tgaggtagggcacccacctgaaggcacttccagtttccagcagcaagactttccagcatc
tgcagagctggagttctgctctcctctaagcgagacccttacaaacatacacagcactct
gcagggctccaatcgaacaaatagaagactgagaagtgga
>IGR201 Sa
gcctgggcctcacttgcatgactcctgccttcttcccttcttgaggtagggcacccacct
gaaggcacttccagtttccagcagcaagactttccagcatctgcagagctggagttctgc
tctcctctaagcgagacccttacaaacatacacagcactctgcagggctccaatcgaaca
aatagaagactgagaagtggatgctgctgggcagaaacgtgcctggcttagcagaggaca
aacgagttaatcttgcaccagtcactctggcccaagaagcctatagctggtgcacttggg
gcaacatagaccctatagacttagtagcaatgatagtattcataataatagctaatgctt
actgaacactccctgtgtgcctggcacctgctaagtatgttatttacattgtgtcattta
atcctcgcagtagtcctgtgggttagatcttactaatgtcatcattttcagataagtaaa
cagaggcactgagaggtagatcataagatcacacaaaaagtgatgaagccaagatttgaa
cttgaacggtctgactcagaaatctttactgttaaccataagtgatataataacagtaag
accttagacttcatatttgtcactgtgtccctacacatcctctggtttttaatcctcaaa
attttgttggatatgttttctcatttccgagaagagaaaa
>IGR2016a
atcataagatcacacaaaaagtgatgaagccaagatttgaacttgaacggtctgactcag
aaatctttactgttaaccataagtgatataataacagtaagaccttagacttcatatttg
tcactgtgtccctacacatcctctggtttttaatcctcaaaattttgttggatatgtttt
ctcatttccgagaagagaaaactgaggggcaaagagatacagtgacaatgccagggttac
acagtgttcaccatccaagtctagcccagagctccctcagtggtatgaccaggaccccct
gtgtaagagcccatgctcccaggtgtcctgaggagtcctttctaatggaagaagttctta
cttccatgtgggtgcttacaagccagagagaaacatcccagagcttcaaaaccagggctt
tgggggagggtgccctgtgtgggtcctagcacatgtgtaacaggcagagggaggtctttg
tgagctaataatgctgcagctcatccaaactaggtgtccctcctgagagatccagagtgg
tctgtttaagccagcctcaagatgggtgtccaagccagatgtcaggggaaaaaaggggaa
gtcagccttttctcagacctgtctggctgggcaggcctgggtctcagactcagcccca.aa
gtctgtggtctctgacctgacacagccttatgtgtatgtg
>IGR2017a
ctcatccaaactaggtgtccctcctgagagatccagagtggtctgtttaagccagcctca
agatgggtgtccaagccagatgtcaggggaaaaaaggggaagtcagccttttctcagacc
tgtctggctgggcaggcctgggtctcagactcagccccaaagtctgtggtctctgacctg
acacagccttatgtgtatgtgtgtattgttcaggaggagatgatcttccagatcccatgg
aagcatgctgccaagcatggctgggacatcaacaaggatgcctgtttgttccggagctgg
gccattcacacaggtgtgtgcctgggactcaggcctaggaagcccagggtagagacaaga
ggaggcactcacgttaacacagaggctcttcactggggtccctgagctccctgagacaac
atgcagaattactgggaagaggggctggtggcagacttgtgtttctggagaagagagtcg
atcatctcagcaaattctcaaagggaaaagccaagatcttagaaagtgtgtggcttcagg
gggtttgtggctagatgaaagttctccctggcaaaagcatctgtgaaaagcagctgtaag
ccagggcactgaaagagacccaggtctgcctttttcttcgtgttgaccaaggcccttggt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-91-
ccaagcctcatgtggttggtggcctcctttatccttgaga
>IGR2018 a
aaagggaaaagccaagatcttagaaagtgtgtggcttcagggggritgtggctagatgaa
agttctccctggcaaaagcatctgtgaaaagcagctgtaagccagggcactgaaagagac
ccaggtctgcctttttcttcgtgttgaccaaggcccttggtccaagcctcatgtggttgg
tggcctcctttatccttgagagatggagctctaggcccatctcagaacagtcagcccacc
catttagtaactgttctctgctgcccagtctgtgcccactctaccctctggctgctgata
gcccaaggaggaagactgggcatagtctgagacacagatagtacactttggggatatggg
gactctagtgcttctggctgggcccttcactgaggcccgctagatgtgtttaagccaagc
ctgggcatttgagaaggcccagggcctaggacctgcagagtgtcaccgggagtacctgct
ggtttgaccactgtggctctctggtagcataagaggtcaggggtaccttgccttcctcct
tcaggccaggggcagctgaggatccctacccatggccctgacgatcctcttttttctcct
gccctctaggccgatacaaagcaggggaaaaggagccagatcccaagacgtggaaggcca
actttcgctgtgccatgaactccctgccagatatcgagga
>IGR2019a
tctggtagcataagaggtcaggggtaccttgccttcctccttcaggccaggggcagctga
ggatccctacccatggccctgacgatcctcttttttctcctgccctctaggccgatacaa
agcaggggaaaaggagccagatcccaagacgtggaaggccaactttcgctgtgccatgaa
ctccctgccagatatcgaggaggtgaaagaccagagcaggaacaagggcagctcagctgt
gcgagtgtaccggatgcttccacctctcaccaagaaccagagaaaaggtatccaaggact
ctgggtccttgggaagccctcagggagggagggtagaaggaggtcagctggggctggaga
gcctgcaccaaggctgacagcccgtctgccccacagaaagaaagtcgaagtccagccgag
atgctaagagcaaggccaagaggaaggtgagtgtggtcctaagcagccaggcctttggtc
acctgtgggccagggtgagcagtggaagaaatgctaaggtgggcctgggcctaagctgct
ttctccctcgacagtcatgtggggattccagccctgataccttctctgatggactcagca
gctccactctgcctgatgaccacagcagctacacagttccaggctacatgcaggacttgg
aggtggagcaggccctgactccaggtgagctggtccaggt
>IGR2020a
cagtggaagaaatgctaaggtgggcctgggcctaagctgctttctccctcgacagtcatg
tggggattccagccctgataccttctctgatggactcagcagctccactctgcctgatga
ccacagcagctacacagttccaggctacatgcaggacttggaggtggagcaggccctgac
tccaggtgagctggtccaggtctggcaggagaccccacaggtcagtgggatgactctttc
tcttggaggcatggtgctggcacatggtggcccattagtgcaggctgcagggttggtcgg
agggcgctcgatgtcttgcaaactaagaaagcacacaaccttgacctgtggcttctgctg
ttccccagcactgtcgccatgtgctgtcagcagcactctccccgactggcacatcccagt
ggaagttgtgccggacagcaccagtgatctgtacaacttccaggtgtcacccatgccctc
cacctctgaaggttggtgctcctggggcctggcctgcctgcttgactgtctgggtcctgt
gaagggcttcctgagagagaaaagatgatcagaactccacctggcactgaattgattgag
ttgggcattgcccagtcttagccaccatagggggaggcaagcgacggggacactaggaag
gcagttcagagtgggctgcagtacagtgggggctggtgag
>IGR2021a
tcctggggcctggcctgcctgcttgactgtctgggtcctgtgaagggcttcctgagagag
aaaagatgatcagaactccacctggcactgaattgattgagttgggcattgcccagtctt
agccaccatagggggaggcaagcgacggggacactaggaaggcagttcagagtgggctgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-92-
agtacagtgggggctggtgagaggagggaagggggccaggggctgcattttggggtgctg
gttctccttcctcctctgtagcccagcatctgagggtgaggaaggaagtagggtaggggt
gggaagcggcgtggcttcagggtttgagaggctgagtcaccaggccagggtcctgttctg
gaatctctatggcagataggtccaccgggagggtgtgtgtgtgtgtgtgtgtgtcagaga
gacagagagacagagaaagggcagggggatctggtgggctggaactggaactgcagggtg
agtgtggctgactgccagccaacctctctgctttccccatccacagctacaacagatgag
gatgaggaagggaaattacctgaggacatcatgaaggtaaagccccttcctacctgggca
ctcttgaagtgaccgtttctcagtgaggagagagaaccagtgaagcttccaaatcagagg
atgggtagctgctgttgtcacctggctgcttgcattgtcc
>IGR2022a
caacctctctgctttccccatccacagctacaacagatgaggatgaggaagggaaattac
ctgaggacatcatgaaggtaaagccccttcctacctgggcactcttgaagtgaccgtttc
tcagtgaggagagagaaccagtgaagcttccaaatcagaggatgggtagctgctgttgtc
acctggctgcttgcattgtcccacaagtgccacattcacgtggcttgactggtgggaaag
ccaccatgggaagggaaggcaggtgggaggcctggcctctgacaggccgtcctgaagcaa
gccttggggcatcagacagctctgtgagtcaggcactatcagcgatgggtccctggcctg
catcctctgccccaacatgccccagccctgctagttcgggaaatgcacatcaggcttcaa
taatcagcctttaggatccgttaatatgatgatggctttatagaaaaagttagcaaatta
tcctccaggtttttttttctgcttcagttttgaaagtgaatatagtttttgcagccgggg
gcagtggctcatgcctgtaatcccagcactttggaaggcgaaggtgggtggatcacctga
ggtcaggagtttgagaccagcctgactaacatggtgaaacccatctctaccaaaaatata
aaaattagctgggcctggtggcgcatgcctgtaatcccag
>IGR2023a
tgcttcagttttgaaagtgaatatagtttttgcagccgggggcagtggctcatgcctgta
atcccagcactttggaaggcgaaggtgggtggatcacctgaggtcaggagtttgagacca
gcctgactaacatggtgaaacccatctctaccaaaaatataaaaattagctgggcctggt
ggcgcatgcctgtaatcccagctactctgaaggctgaggcaggagaatcgcttgaacctg
agaggcggaggttgcagtgagctgagattgtgtcattgcactccagcctgggcaacaaga
gcaaaactccatttcaaaaaaaagtttttgcagtagttgtacgccagctgttccattagc
ccaaaaaattgagacatggatgtcgttccttatctctagcttttctagtcatcttttctt
gatttattatgctaacctttgttttaagccacattccctcttactatgtccttacacagt
tgagagggaagtcgtggagatgctataccagagagtgggtgtgagaggggtgggaaaatg
aattgaggaccagtgccaacatgcatttctgcctcctccctcccgggcccttgtcctgac
tgcagtgcacttctgcatcctatctgagattgtgaaaatggccaagggtgtgatactggc
tgagaggagctggctcattgagggcagggccacagggtga
>IGR2024a
atgctataccagagagtgggtgtgagaggggtgggaaaatgaattgaggaccagtgccaa
catgcatttctgcctcctccctcccgggcccttgtcctgactgcagtgcacttctgcatc
ctatctgagattgtgaaaatggccaagggtgtgatactggctgagaggagctggctcatt
gagggcagggccacagggtgagtctgcactggaagggagttgatagcctcttgctcttct
gtccccagctcttggagcagtcggagtggcagccaacaaacgtggatgggaaggggtacc
tactcaatgaacctggagtccagcccacctctgtctatggagactttagctgtaaggagg
agccagaaattgacagcccagggggtaagaaggccctggatccttatggcttcttagatg
agggagaaccacgtagggatggagaaagcttgggggcagggccagggagcagggcggtaa
agcatctggggtactgacacattgtgaattagctacggctgccatgccttaaggtttgcc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-93-
tgaagctgagtggatgtttactgctgtgctgggaagagcagaggccatgtctatggcctt
caggggtagggggaagcacacctgatgccaccgtcccctaccctcatacaaccttcttca
catcttctaggggatattgggctgagtctacagcgtgtct
>IGR2025 a
cattgtgaattagctacggctgccatgccttaaggtttgcctgaagctgagtggatgttt
actgctgtgctgggaagagcagaggccatgtctatggccttcaggggtagggggaagcac
acctgatgccaccgtcccctaccctcatacaaccttcttcacatcttctaggggatattg
ggctgagtctacagcgtgtcttcacagatctgaagaacatggatgccacctggctggaca
gcctgctgaccccagtccggttgccctccatccaggccattccctgtgcaccgtagcagg
gcccctgggcccctcttattcctctaggcaagcaggacctggcatcatggtggatatggt
gcagagaagctggacttctgtgggcccctcaacagccaagtgtgaccccactgccaagtg
gggatggggcctccctccttgggtcattgacctctcagggcctggcaggccagtgtctgg
gtttttcttgtggtgtaaagctggccctgcctcctgggaagatgaggttctgagaccagt
gtatcaggtcagggacttggacaggagtcagtgtctggctttttcctctgagcccagctg
cctggagagggtctcgctgtcactggctggctcctaggggaacagaccagtgaccccaga
aaagcataacaccaatcccagggctggctctgcactaaga
>IGR2026a
gctggccctgcctcctgggaagatgaggttctgagaccagtgtatcaggtcagggacttg
gacaggagtcagtgtctggctttttcctctgagcccagctgcctggagagggtctcgctg
tcactggctggctcctaggggaacagaccagtgaccccagaaaagcataacaccaatccc
agggctggctctgcactaagagaaaattgcactaaatgaatctcgttcccaaagaactac
ccccttttcagctgagccctggggactgttccaaagccagtgaaatgtgaaggaaagtgg
ggtccttcggggcgatgctccctcagcctcagaggagctctaccctgctccctgctttgg
ctgaggggcttgggaaaaaaacttggcactttttcgtgtggatcttgccacatttctgat
cagaggtgtacactaacatttcccccgagctcttggcctttgcatttatttatacagtgc
cttgctcggcgcccaccaccccctcaagccccagcagccctcaacaggcccagggaggga
agtgtgagcgccttggtatgacttaaaattggaaatgtcatctaaccattaagtcatgtg
tgaacacataggacgtgtgtaaatatgtacatttgtctttttataaaaagtaaattgttt
ataaggggtgtggcctttttagagagaaatttaacttgta
>IGR2027a
cccctcaagccccagcagccctcaacaggcccagggagggaagtgtgagcgccttggtat
gacttaaaattggaaatgtcatctaaccattaagtcatgtgtgaacacataggacgtgtg
taaatatgtacatttgtctttttataaaaagtaaattgtttataaggggtgtggcctttt
tagagagaaatttaacttgtagatgattttactttttatggaaacactgatggacttatt
attggcatcccgcctgaacttgactttggggtgaacagggacatgcatctattataaaat
cctttcggccaggcgcggtggctcacacctgtaatcccagcactttgggaggccgagatg
ggtggatcacctgaggtcaggagttcgagaccagcctggtgaaactccatttctactaaa
aatgcaaaaattagctgggcgtggttgcgggtgcttgtaatcccagctactcaggaggct
gaggcaagagaatcgcttgaacctgggaggtggaggttgcagtgagccgagaacatgcca
ttgcactccagcccgggcaccaaaaaaaaaaaaaaaaaaaaaacctttcatttggccggg
catggtggcttatgcctgtaatcctggcactttgggaggccaaggtgggcagatcacctg
aggtcaggagtttgagaccagcctggccaacatggtgaaa
>IGR2028a
aacctgggaggtggaggttgcagtgagccgagaacatgccattgcactccagcccgggca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-94-
ccaaaaaaaaaaaaaaaaaaaaaacctttcatttggccgggcatggtggcttatgcctgt
aatcctggcactttgggaggccaaggtgggcagatcacctgaggtcaggagtttgagacc
agcctggccaacatggtgaaacctcatctctactaaaaatacaaaaattaggccgggcac
ggtggctcacgcctgtaatcccagcactttgggaggcagaggcgggcggatcacgaggtc
aggagatcaagaccatcctggctaacacggtgaaaccccgtctctactaaaaatataaaa
aattagccgggcctagtggcgggtgcctgtagtcccagctactcgggaggctgaggcagg
agaatggcatgaaccccggaggcagagcttgcagtgagccgagattgcaccactgcacta
cagcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaattagccgggcct
ggtggcgggcgcctgtaatcccagctactgtggaggctgaagcacaagaatcacttgaac
ccgggagatggaggttgcagtgagctgagactgtgccactgcactccagcctgggtgaca
agagtgagactttgtctcaaaaaaaaaaaaatccttttgt
>IGR2029a
agactccgtctcaaaaaaaaaaaaaaaaattagccgggcctggtggcgggcgcctgtaat
cccagctactgtggaggctgaagcacaagaatcacttgaacccgggagatggaggttgca
gtgagctgagactgtgccactgcactccagcctgggtgacaagagtgagactttgtctca
aaaaaaaaaaaatccttttgtttatgttcacatagacaatggcagaaggaggggacattc
ctgtcataggaacatgcttatataaacatagtcacctgtccttgactatcaccagggctg
tcagttgattctgggctcctggggcccaaggagtgttaagttttgaggcatgtgccatag
gtgatgtgtcctgctaacacacagatgctgctccaaaaagtcagttgatatgacacagtc
acagacagaacagtcagcagcccaagaaaggtcctcacggctgctgtgctgggtagcact
tgccatccagtttctagagtgatgaaatgctctgtctgtaccgttcaatacagtaggcac
tggcactagccacatgtgccagctaagcacttgaaatgtggccagtgcaataaggaattg
aacttttaattgcatttaataaactgtatgtaaatagtcacatgtggtcagtggttacca
tattgaacagtgcaggtagatactggactgggggcagatc
>IGR2030a
tgatgaaatgctctgtctgtaccgttcaatacagtaggcactggcactagccacatgtgc
cagctaagcacttgaaatgtggccagtgcaataaggaattgaacttttaattgcatttaa
taaactgtatgtaaatagtcacatgtggtcagtggttaccatattgaacagtgcaggtag
atactggactgggggcagatctgagggagaggggtttgagtagtgggaggacactgggga
taggggcttggggctatttacctgccattttgagtagtttgctattttagcagccaacaa
taactattggtgctgaataccagccctgcagtgtagcatgagacaggtccatgcacacat
gcattaggaaaacaccttcatgaagcaggattctgcctgggctgatgcacacaacctcta
tggagggtaaacagtgtttctgaagaccgtagtttgggaacccctgacatatgacaatgc
ccccttagataagctcaagttacaggaatgtctgagggtggaaggtgtggatatgtgctt
ttcctgtctccctcttcagtgtctggccatggggcataaacactacccagcagtaggtag
gctggccaagagaagccagcttgcatcaccagcatcatctagggaatggaatcatggcag
taatacgttgcttaggaaacaaaagctctatggacacatc
>IGR2031a
ttacaggaatgtctgagggtggaaggtgtggatatgtgcttttcctgtctccctcttcag
tgtctggccatggggcataaacactacccagcagtaggtaggctggccaagagaagccag
cttgcatcaccagcatcatctagggaatggaatcatggcagtaatacgttgcttaggaaa
caaaagctctatggacacatcttccaccttctcagtcccagaaaccatatgtactgtgac
cccgctcactaggcccagccctcgggaagagtgtgggcccttgaaaagggaagactgagt
gagaaaatgatgagaaaactacaaaatgggcagaggtcagtctgacacattcattctctg
tcaagctcaggaagtactggtccctgatcttggagatgctgtgtgagtggcagggggact
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-95-
cctgctgggtaaatattctatatgtggatgcctggacaggcccctatcccaggccctgct
tgtcagaagctccccttgggccgagcgcggtggctcacacttgtaatcttggcactttgg
gaggccgaggcaggtggattgcctgagttcaggagttcaaaaccaggctgggcaacatgg
tgaaaccctgtctctactaaaaaaaaactaaccaggcgtggtggtgcatgcctgtaattc
cagctactagggaggctgaggcaggccaatcacttgaacc
>IGR2032a
gccgagcgcggtggctcacacttgtaatcttggcactttgggaggccgaggcaggtggat
tgcctgagttcaggagttcaaaaccaggctgggcaacatggtgaaaccctgtctctacta
aaaaaaaactaaccaggcgtggtggtgcatgcctgtaattccagctactagggaggctga
ggcaggccaatcacttgaacccaggaggtggaggttgcagtgagctgagatcacgccact
gcactctagcctgggcaacagagcgagactctgtctcaaaaaaaaaaaaaaaaagaagtt
ctacttggaagctccacttggatttctcaagaatagcttcacctgggaacagaggaatag
acaggatggacttttccagctccttcagggaccagccctttttaagatttggattgaggt
ggctagccacctgtggcttccatctgggttctcctagtgggtgatggcaggtggtgcaga
gcaaggtagagtggactgacgggaggaaagtgataccacccagaacaagcagcagctctg
acttctttttctcctgcccttcaatctaatccctgatggagggtaggcagtgagtatgtg
aagtcttaggcagctgtggaaatctctcaagttctaaaagcaaagttaattgcttgtaaa
ttaccaaaaagagagaggaattatgtccatcagcttccaa
>IGR2033a
cgggaggaaagtgataccacccagaacaagcagcagctctgacttctttttctcctgccc
ttcaatctaatccctgatggagggtaggcagtgagtatgtgaagtcttaggcagctgtgg
aaatctctcaagttctaaaagcaaagttaattgcttgtaaattaccaaaaagagagagga
attatgtccatcagcttccaatctccacaaccaagatggagtcctcaatttccccatccc
ctctgatcccaggagtcctaaatgattggtagcaattgcttggaatctccagggagggac
ctcaaaactctcccctggcccccatcacaatggagctgggtcctagggaccaagcctgga
gtagtgtgggatagagccagacctttcaggatggagagctgtcccatcacatcctaccaa
gacttcagccttttcctaggaaaagaaactaaataaggtctgacagctcacctaaaggtg
atggcagctgacactaccgagtcattagccaaacagtgcctgaaacggagcagtattagt
aagatctgaaccaagtttgtgcttaataattagatcattctaaggacctgacagtgcttc
tgtgggtcattctcaagagtttcagtataagcactaatggtggaagttctaggttgaggg
agctaggaggttgttgaaagatctgttttgctggggttgt
>IGR2034a
agtcattagccaaacagtgcctgaaacggagcagtattagtaagatctgaaccaagtttg
tgcttaataattagatcattctaaggacctgacagtgcttctgtgggtcattctcaagag
tttcagtataagcactaatggtggaagttctaggttgagggagctaggaggttgttgaaa
gatctgttttgctggggttgtgatgagataactgtcatcaaggaccactttccactgggg
taaactgacaaaagtggtgctcagccacaccagctagatttctcatgttgggccaagttt
acagacatttgcgggcatttgtggttagtcatgggtttccttgccttaactccaaaaggg
tatagctggctggtcactttcattgggctggtttattcattcagctcacttggcaatagg
aagaaagctagaagctaataggcaaaccatcccttcttggtgtgtcagctttcaacatct
ctcagtgcactgtgtgcagggtgttgtgaccattacaactccaaaggaaagagctttctc
tgatttttctggaagtctccagtggggcctgccaaagtgggaactgaaatcctggggtag
ccctgggaagtggagtttttttctctaggagtgatgtctcctggttggtggggctgggaa
acagccaggttgtcattctctgggaccacttgatctttca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-96-
>IGR2035a
ggtgttgtgaccattacaactccaaaggaaagagctttctctgatttttctggaagtctc
cagtggggcctgccaaagtgggaactgaaatcctggggtagccctgggaagtggagtttt
tttctctaggagtgatgtctcctggttggtggggctgggaaacagccaggttgtcattct
ctgggaccacttgatctttcacactgtgtacagatccaaaactctgcccttatacttgga
ggggaaagggggtacagatgtcctccaggcagtcctgttggagcacccagggctaatata
gtgaccctatagaaagcttttgtctctgtcagatgtaatgctgttccttaacttgggcac
aactgatcttccaattcatcagaactcagcactaacctttccccagttctgctggctgtc
acagaggaaggaggcctggggtgggagaaggggaagctggtgccctccttttccaggggt
gaaagtacttggcagggtggagcttggctttatcatccggagctcccttgtggggccaag
tctaaggcctcagaagggtatagctggctggccgcatagttttcctagctccaggcagct
ctcaagagacccatttatgctggttttctcagggtaaggagttacagaagtccacctctg
ctggctcagtggtaagacacaagcctgcagagtctgctga
>IGR2036a
gagcttggctttatcatccggagctcccttgtggggccaagtctaaggcctcagaagggt
atagctggctggccgcatagttttcctagctccaggcagctctcaagagacccatttatg
ctggttttctcagggtaaggagttacagaagtccacctctgctggctcagtggtaagaca
caagcctgcagagtctgctgagtgaaacttcagctggggagatactggaggctatggagc
aaggacatggggactgaatgaaagaggggaggcagacgtccagcccaccattcctcaccc
aaggagatgatcccacaagctcacaaatgagcagaactggaaaagacctcaaagtgtggc
tggataatggcaacacaggcctcgagtgctcactttgtgctgggtgctatgccaagcacc
acgtgtgtaccacggcactggcaccccaccacggcccttgttcacagaccaggaaaccaa
ctctcaccacctaatcagtatggagccttggttccaacccacatcatctatctgtgccca
gaatccaggttggttccatatcaggctgcctgagagaagaacacggaggcctgcacaaga
agctggggagagctagcaaggggcagggcccgagcaccttatgccaagcaagcacttgtg
gatgctgagggaaggcggcaaaagctgcagctgctgtgct
>IGR2037a
atggagccttggttccaacccacatcatctatctgtgcccagaatccaggttggttccat
atcaggctgcctgagagaagaacacggaggcctgcacaagaagctggggagagctagcaa
ggggcagggcccgagcaccttatgccaagcaagcacttgtggatgctgagggaaggcggc
aaaagctgcagctgctgtgctgccctgccttcagctctcctcccttcccccagcacacac
accttccaacacccctggcaacatggctctgccgctacaggccccagggccccaacaggg
tagggtttgccccacctatgccctggaggccacctgcagtttcgaagggtggggccccag
ggggccgagacacagacaggcttgtaacttggcctcagtgcagggggcagcttggccaca
ccaggcctgtttggagcaaacgggggactctggcctgctaggccttatctcagctcccag
gatcaaagaggactttttagccatgtttctgtctcagcaagacaacctagtctcctgttc
tgctttaaaccagaccctctgttgggtcctggagttcctcagaggtctggaccctggatg
gctgtgagactcaggaccatgcacagatgcattctcattcccagccaccaggctcgggtc
agaccctatggctctggtgggcctaattcctggtttcttg
>IGR2038a
gccatgtttctgtctcagcaagacaacctagtctcctgttctgctttaaaccagaccctc
tgttgggtcctggagttcctcagaggtctggaccctggatggctgtgagactcaggacca
tgcacagatgcattctcattcccagccaccaggctcgggtcagaccctatggctctggtg
ggcctaattcctggtttcttgatccctgagaacacctggcacctctggctgctggccagt
tgccaccttacatcaggcgggcgctgggattcacctgcaggcttcctttagggaaggccc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-97-
tcccctgccctcctgtgccagcccagaggggcagcctgggtgaggtcttcacatccattt
cgggccaaatgccttggattggctggatcccctcctgtttctgccctccttctttccttc
aaagcaacaaggttgtgggggtgtccagttctgctaccacctctccctcacactgtcaat
ctggaatttgtccagaattggggcccaagtagtgagttcttacacagtggttaaacaaac
aaacaaacaaaaaccccacacaactcagctacaccttggctcagagaggccatgggatat
accgaggatctcagatcaggagggaggcccctggagaggtgtggcggggatcatgtgctt
ctctggtttcttggagaaagctgactttgtgtaacaaggg
>IGR2039a
ggggcccaagtagtgagttcttacacagtggttaaacaaacaaacaaacaaaaaccccac
acaactcagctacaccttggctcagagaggccatgggatataccgaggatctcagatcag
gagggaggcccctggagaggtgtggcggggatcatgtgcttctctggtttcttggagaaa
gctgactttgtgtaacaagggaggcatatggacatggagttggtgtttggggatgtggga
accattaggccagaattacaagaagtcctgtcatgtcggccacactagggcaacagtgga
ctggggcaggggctgatgacctgattgtggaggcagtggagggctgtttctgctggggac
ccagggctcccctccaagtgctcctgcttggcttgttgggatggggagaggagctggagt
tgggatggggagaggagctggagttgggatgggtcacagcgaaggctacagcctggcatt
cccatatggggtaggggtggggtggggtgggacagggaggaggacctgaaggggtgtcca
actttccgagacttggaacagcctggtgagtgttcatcaccattcttctgtcataggtgg
cgagcagccagagttctgggcacaggagaccatctacccccaagcttgtgcggcctgcct
caggtcactgaagaggaccccatttttggtctttggccat
>IGR2040a
gggtggggtgggacagggaggaggacctgaaggggtgtccaactttccgagacttggaac
agcctggtgagtgttcatcaccattcttctgtcataggtggcgagcagccagagttctgg
gcacaggagaccatctacccccaagcttgtgcggcctgcctcaggtcactgaagaggacc
ccatttttggtctttggccatcctaagacttgtacaatggagccctggggccctcccttc
tctgaccagtgacagccctcacaggcaaagcctcaccctctagggcctgtcccttcctgt
ctgccagtccccacagggtctgcggggtacccaatctcgccaaccagactggaagctccc
caggggcaagcagcttatctcttccatattctcacagtgttcagccaggattggcacttc
agagcatctcctgctgctcagcagagatgtagttagcatctctctatagtagcactttct
gagtccctcccctgggggaaccaggctagactctggggtccagaggagcaggcaggctga
gaggcaaaaagggcacagaggaataaccaaccctgcccctgcagtagagccctgggcaaa
acaggccatgaccaaccagcagccaaggtcaaagtccccagaacaagggccagtgtgtgc
atgacatgcagcaggaccgcttgtctctttcggcagtact
>IGR2041a
accaggctagactctggggtccagaggagcaggcaggctgagaggcaaaaagggcacaga
ggaataaccaaccctgcccctgcagtagagccctgggcaaaacaggccatgaccaaccag
cagccaaggtcaaagtccccagaacaagggccagtgtgtgcatgacatgcagcaggaccg
cttgtctctttcggcagtactggagatagaaggctgagtcattaacaactttcttttatt
aaaaatgtacataagtaaaaggaacatggtttaattgtgcaaagagtaagaaatacagat
gagcaaataacacgtattaaagccacctacgatataccacccagaagtaaccaggctgtt
gaatttttagagactggggtgcaaacacattttttcactcccttgtgcatatatctggga
gctctgccatatacagacacagacgcggtgtccacaggcgatgcctctgctgggaatgct
gcaagcaggagtctatcctttcctggtactggctcgggggccctcctcagcgcccaggtc
actctagcatccaggagtccaaaggcccggctgtgcaggctgcagaggtgatctagagta
gattaggaggtgcaaaaggcttggagataggctgaccaactgttccagtttgcttaggac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-98-
tgaggagtttcccaggatttgggactttcagtgctaaaac
>IGR2042a
ttcctggtactggctcgggggccctcctcagcgcccaggtcactctagcatccaggagtc
caaaggcccggctgtgcaggctgcagaggtgatctagagtagattaggaggtgcaaaagg
cttggagataggctgaccaactgttccagtttgcttaggactgaggagtttcccaggatt
tgggactttcagtgctaaaactgggaaagtcccaggcaaaccagggccagttggtcaccc
tccctgagggccaaaggctttgtcctgcccctcctgccctgtgctccccatctgccctcc
tgctggggttctggatcccccatccccacaccaagcagcccagggacagaggcctggctg
gggccttgcctcccgtggaagctcctgaaagttccagcctgaggcctagggagggacagg
ggaaagggaataaattaaggcagacagtctgtcatcacccaagaaaagggccaggtgaac
tgtggctgttaagggcagctagggatgtacaagcagaagggttccaatacttggctggcc
acccctccagccctggagctgagtgtgtggtccccagaggccccagagccagagaagtgc
agggtgtctggattgaaaggcctcagctccctgggctcccagagccctggtgcctcaggc
cttaccttccccctcctccatctccacaccccctggcact
>IGR2043a
tagggatgtacaagcagaagggttccaatacttggctggccacccctccagccctggagc
tgagtgtgtggtccccagaggccccagagccagagaagtgcagggtgtctggattgaaag
gcctcagctccctgggctcccagagccctggtgcctcaggccttaccttccccctcctcc
atctccacaccccctggcacttcctgctcagctcttctctacctaagactgggagcagag
gatgaaggaagaggaatccaggacagaccgagctgaaagaggagcaggcaggtgggaggg
gacttgggtagaaaggacctctctgatagtggcaggaacatcctgactgtggtctggccc
agccggctgtctatgcctgaggatgcctgaggatggggggcccttggaaaactcagaaga
gaggctaggtgtggaaggcagagtattggtccacagtggaataaagaggtccacgtccta
atgcatgagcctatgaatatgttgctacatggcaaagaggaattaaaactgcagatggaa
ttaaggttgctaaccagctcacttgcaaatagagagattaccctggattattggtgtggg
cccagtgtaatcacaagggttcttaaatgaagaaggaggaggcagaagggtcagaaccag
agagatcgcattgtgaaaaacctgaccagccagtgctggc
>IGR2044a
tgttgctacatggcaaagaggaattaaaactgcagatggaattaaggttgctaaccagct
cacttgcaaatagagagattaccctggattattggtgtgggcccagtgtaatcacaaggg
ttcttaaatgaagaaggaggaggcagaagggtcagaaccagagagatcgcattgtgaaaa
acctgaccagccagtgctggctttgaaagtggaggaaggggttgcaggccaaggaatgca
ggcagcctctaaaagctggaaagggaaaggaaggaaagggattctccactagagccccca
ggaagaaatgcagctctgttgacaccttgagtttagcccagtgagacctgttttggactt
ctgactacagaactataagaaaagaaacgggccaggtgcagtggcttacacctgtaatcc
tagcactttgggaggctgaggcaggcagattgcttgtgcccaggagtttgagaccagcca
gggcaacatagtgagaccctgtctctataaagtatacaaaaaattagccaggtgtggtag
cacgtgcctttagtcctggctacttgggaggctgaggtaggaggatggcctgagcccagg
agggagaggttgcagtgagtcaagattgagccactgcactccagcctgagtgacagagca
agaccctgtatccaaaaaaataaataaataaaaaattgtg
>IGR2045 a
tgtctctataaagtatacaaaaaattagccaggtgtggtagcacgtgcctttagtcctgg
ctacttgggaggctgaggtaggaggatggcctgagcccaggagggagaggttgcagtgag
tcaagattgagccactgcactccagcctgagtgacagagcaagaccctgtatccaaaaaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-99-
ataaataaataaaaaattgtgttgttttaagcccctgtttatgataatttgttagagcag
caataggaaactgatccactgggaaaccatttgggggatgcagctgcccaaaatccctgc
acgtgggttggactcagcctcacaaggctctacagcctctctgtgaaagactccattccc
tctgggagaagctcagactctaaagccctgggcagggaatgggcctccatggcatggagg
gggtcaagaaggatgccccccaggatagtgcctctgctggacctctctataggaagcagc
tgcctctttgagccccctccccaaacctcagtgagctgaggtgctggctctgagtggtca
tggaggggcttgcctgaggtcaggccacctaggacagctagtcagaggccacagggcttg
gcttaagattcccaggaaggagttgcatggcccctccacacatccgcaatactcataaca
ctctcagtccttggccttactaagggaatactaaggggac
>IGR2046a
cccaaacctcagtgagctgaggtgctggctctgagtggtcatggaggggcttgcctgagg
tcaggccacctaggacagctagtcagaggccacagggcttggcttaagattcccaggaag
gagttgcatggcccctccacacatccgcaatactcataacactctcagtccttggcctta
ctaagggaatactaaggggactcagtttagctctggaaaagctaggactactggaaaaaa
aagtatagaggaaaaaaaatagttactggatgccagccagatctgcaaaaagtccccact
ctgccacttactagctatgtggcctcaaataagccactagaccttttgtagcctcagttt
cttcatctgtaaaatgggtataacatcatttgtcttatctgtctcacagggtgtgtgagt
ctcaggtgagataacacacgagaaaacattgtgccgcacaacttgagatgcaaacagtaa
cgatcacaaccccacatgccttttgatagggtgaatgatcacagcatcctgtgttaggga
ggaaagggtgagcacagacgcttcaaaactctgtcttacccataggcagaagggtgtagc
ctggccaggggagaaaaggacccagccactgccaccgccccgcagctcacaccggatgtg
cgacagagccaccatgcagccccacaggatgtcctccaac
>IGR2047a
cttttgatagggtgaatgatcacagcatcctgtgttagggaggaaagggtgagcacagac
gcttcaaaactctgtcttacccataggcagaagggtgtagcctggccaggggagaaaagg
acccagccactgccaccgccccgcagctcacaccggatgtgcgacagagccaccatgcag
ccccacaggatgtcctccaaccactacagactgtggggctttgctttttttttttttttt
tttttttttaagaaaaaggttttctagtttcttctacattaaaaacaatccctccttctc
ataaagcacaattttacagaggaaaagggagatgtgaaactatacacaattcaaatctaa
ttaatatataatttttttgtggaatacagatggagggaatacatcacaatactaaaggtg
attatctttggatggtgggattacaggtgattatatattttttatatttctatagtttaa
aaatattccatgatgacctataattacttttacttattttttgagacaaaatctcaccct
gttgaccaaggctggagcgcagtggtgcaatctcggcttagtgcaatctcggtgtagtct
cgacctcacaggctcaagtgatcctcccacctcagcctccggagaagctgggactacagg
tacataccaccatgcccagctaattttttgtagagacagg
>IGR2048a
ataattacttttacttattttttgagacaaaatctcaccctgttgaccaaggctggagcg
cagtggtgcaatctcggcttagtgcaatctcggtgtagtctcgacctcacaggctcaagt
gatcctcccacctcagcctccggagaagctgggactacaggtacataccaccatgcccag
ctaattttttgtagagacaggatttcgccatgttgtccatgctggtctcgaactcctgag
ctcacataatcctcctgcctcggcctcccaaagtactgggattataggtgtgagccacct
tgactggcctataattacttttataatcagaaaaaaaattataaataaatatgaaaagtg
ccaggaactttcttttgtggagccacacactgggctcaaggaatcatttgagctgggttc
tgcaggggtgggagtcttggcgcgggccctggtccttgctgtgtgaccctggagactcac
tactttccctccctggcctttgtttgcctggtaagacaagatgctccctagggtcctttg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-100
cagcttaataagtaaagtattcgccttggtctcatccatcccagctctttgcccagcttc
cagtgactcctctgtgcctggagagaagggcaagcgccttactcatgccttgaggttgct
gaccacttccgtcaccagcctcgctccttccagacctgcc
>IGR2049a
ttgtttgcctggtaagacaagatgctccctagggtcctttgcagcttaataagtaaagta
ttcgccttggtctcatccatcccagctctttgcccagcttccagtgactcctctgtgcct
ggagagaagggcaagcgccttactcatgccttgaggttgctgaccacttccgtcaccagc
ctcgctccttccagacctgccctgggagtccctgcctcctggccttcacctgcatcacgg
tctgcacttctcagagccctgcccttccttgaagaacaaagcctggccaaattgtgtcag
ccttctggcctgcagtgacccctgcttacattgtacataacaatagctataacttattga
cattaacttcaggtcacatagcaaaagtgctctcatttaaatcttaggccaccagaggat
ccatagactaaaatgttaacagcatctcctggagttgtggagtgtggtgaccctatgtga
tcctcctgtgccactgagagatatattattaacccagtttcactgataagataactgagg
ctcagagaggtcaagtaacttgcccatggtcacacagtgggtccatggcagagctgggag
gtgatccctagtcagttccctccaagtccaggattttctcactcccacaatggtgtctcc
cttaatgactctcacattccagcctctgagggcaggaagg
>IGR2050a
gatatattattaacccagtttcactgataagataactgaggctcagagaggtcaagtaac
ttgcccatggtcacacagtgggtccatggcagagctgggaggtgatccctagtcagttcc
ctccaagtccaggattttctcactcccacaatggtgtctcccttaatgactctcacattc
cagcctctgagggcaggaagggtatgttctgagttgaacacacagagagcactcaatgat
gtctggtggtgaagatgttaatcatgagctcaatcaaggtttatcattaaatcaacaagt
cttcctagtgtgtctgggagctctggggcccagggacaggcctactgtagttcagtgttg
tattctggcacctggtggtttctggcacatagcccatgttcattaaatgacatgaattga
ttgtccattcaaataataaaacaataaataaataatactagctaacaggtatggagtgcc
tacaagccagccacctcagggagtttccaggacagttgaggagaaacataacactgttga
caagagctacaacgtagggttttacaccaaaacagtgtctacgtaaacagtgtctatcaa
agagagaaaaatgatgggcagacaccctgatccttcccacagtgctaaaggccatgccag
ccactgtccccattacgacttgcatatactgactgccgaa
>IGR2051 a
ggagtttccaggacagttgaggagaaacataacactgttgacaagagctacaacgtaggg
ttttacaccaaaacagtgtctacgtaaacagtgtctatcaaagagagaaaaatgatgggc
agacaccctgatccttcccacagtgctaaaggccatgccagccactgtccccattacgac
ttgcatatactgactgccgaagcacacaaacctgaattttccgtctgcatccatcgttct
gtctgttcggatcacatctggatactactgttgcctctccagactggataaccagtctgc
tgagggccagaagatggtgagatggaaactagtcatgtttacttggagaagagaaatgaa
gaccgtctttaacacctgacaggttgctcttcccaagaggggccagagggcaacagccat
ggtcaacagctccaggcacccctgaggaagcctgctccagctggcagggttgtctggcaa
gggaccagtccctcctctggagaagtggtgagcccagtgggctgcctctccagcaggatc
ctgtagagaccttactctctacaatgcacactccacacacttgctcacttgacaaacact
tattataactgtcaccctgggcccattccaggttagggacataaggatgaataaaacaag
gtctgtaccagtagagaacatcagtcccctaggggagaaa
>IGR2052a
gagaagtggtgagcccagtgggctgcctctccagcaggatcctgtagagaccttactctc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-101
tacaatgcacactccacacacttgctcacttgacaaacacttattataactgtcaccctg
ggcccattccaggttagggacataaggatgaataaaacaaggtctgtaccagtagagaac
atcagtcccctaggggagaaagtcaggaaagcctcatcctgagccttcgactccttactg
tccatcctctaggctcctgtctcagcttctgctgaaggctattttcttccttgtattctg
cagtgaccaggcatatggcagataatcaacaaatacaggcatccctgaagagggtatcct
gggataaaagccccagctggatcagtgctatacaggggccaactgggggtgggttccagg
cagggtcatttgcaagggtccctctgccccttcaagtcctgccagacaggccttggccat
ggtttcttcctgcccctgtcccctgaccacagttgatctcccctggctgttatgaaatgt
caaagaatgtcctgcaatcctaaattccataatgatctttatcttctgttccctctgagg
ctcctcaatctgcagtaacagctgtggttcagcaagcagtgcggcactctggagtgctgt
tctgaaacagggccggcgtggggcagagctcatctgctgc
>IGR2053a
cccctgaccacagttgatctcccctggctgttatgaaatgtcaaagaatgtcctgcaatc
ctaaattccataatgatctttatcttctgttccctctgaggctcctcaatctgcagtaac
agctgtggttcagcaagcagtgcggcactctggagtgctgttctgaaacagggccggcgt
ggggcagagctcatctgctgccctatccattcactgtgctgttcagggctagagaagatt
catgtgtgtatatgctttttaaaaattgtgaaacaataattatgcagaaaaatacataga
atatatgttcagtttaacaaataatcataaagcaaatctctataaaaccactgctgctct
gcagtgacacctgcttccccctaagtcgtgcataacaatagctacaatttactgaccatg
aacttcaggtcacacagcaaaggtgttctcatttaatctttggccaccagaggctgcata
gactaaaatgtgaacagtgtcccctgcagttgtggagtgtggtgaccctattggatcttc
tcacgccactgagggatatactgttttctgtagagaagtccagcagagtcactgtcctgg
ggggcatccttcttgatcgcccccatgccatgaaggcccattccttgcccagggctctag
agtctgagcttctccaagagggaatggagtctttcgcaga
>IGR2054a
tcccctgcagttgtggagtgtggtgaccctattggatcttctcacgccactgagggatat
actgttttctgtagagaagtccagcagagtcactgtcctggggggcatccttcttgatcg
cccccatgccatgaaggcccattccttgcccagggctctagagtctgagcttctccaaga
gggaatggagtctttcgcagaggggctgtggagcctcgtaaggctgaatctaaccacgag
cagggattttgggcagctgcatatcccagatggtttcccagtggatcagcttcctgttgc
tgctctaataaactaacataaacttaggggcttaaaacaacacaaatttcttttcttata
gttccgtaggtcagaagtccaaaacaggtctcactgggctaaactgaaggtgtcagcagg
gctgcattccttcctgggggctctagtagagaatctctttcctttcttcccctttccagc
ttttagaggctgcctgcattccttggcctgcggccccttcctccaccttcaaagccagca
ctggctggccaggtctttcatatattgcaatctctctgcttctgcttctgacccttctgc
ctctctcttctccatttaagaatgcttgtgattacattgggctcacccaccccagtttct
acccaataatccagggtaatctcccaaacttaaagagaga
>IGR205 S a
tccttggcctgcggccccttcctccaccttcaaagccagcactggctggccaggtctttc
atatattgcaatctctctgcttctgcttctgacccttctgcctctctcttctccatttaa
gaatgcttgtgattacattgggctcacccaccccagtttctacccaataatccagggtaa
tctcccaaacttaaagagagaaaacaatactagcacccccaaagcacctacgtgttcccc
tactaatcacaaccccaaccctcccttctgcataagtagacatttgtaataattctgtgc
tttttgtagtttgacctcctctgcatgtatccttaacaatacagttttgccagctgttaa
atttttgctaaaaggaattatactgtatgcattcttttgtaggttttattcattgatgag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-102
tcatttgttattacagtattattatccaatatgacaatattacagttattgcaagtcgct
gtagttcatttcactccaggaacactgcacaatttatttgtactctccacttttgatggt
catttggacattttctggtgctgtgtgggtattctggtgcacatgggtaagagtgtggtt
tgagaagattctgaggagtgggactcttgggttacagggtatatatatgttttcatcttt
taaaaaaatttatattattcatttttttaaagactagtca
>IGR2056a
gaacactgcacaatttatttgtactctccacttttgatggtcatttggacattttctggt
gctgtgtgggtattctggtgcacatgggtaagagtgtggtttgagaagattctgaggagt
gggactcttgggttacagggtatatatatgttttcatcttttaaaaaaatttatattatt
catttttttaaagactagtcactgggcgcggtggctcacacctgtaatcccagcactttg
ggaggccgaggccggtggatcatgaggttgggagattgaaaccatcctggctaacacggt
gaaatcccatctctattaaaaatacaaaaaattagccaggcgtggtggcaggcgcctgta
gtcccagctactcaggaggctgaggcaagagaatggcgtgaacccgggaggaagagcttg
cagtgagctgacatcgcgccactgcactccagcctgggtgacaaagcgagactccatctc
aaaaaaaaaacaaaaaacaacaacaaaaaaagactagtcaagggcagtagtgagaagggg
gaaaagagtagaacaaggagttcgatctgtaactgactgtgaagtcaattgagataattc
actaccttcagatcagccatgttttcatctttaccagatcacttatatgctttattttct
ttacttatatactttttaatcctgaaagtgtttctcaggg
>IGR2057a
acaacaaaaaaagactagtcaagggcagtagtgagaagggggaaaagagtagaacaagga
gttcgatctgtaactgactgtgaagtcaattgagataattcactaccttcagatcagcca
tgttttcatctttaccagatcacttatatgctttattttctttacttatatactttttaa
tcctgaaagtgtttctcagggaaacagtggtattacacccagttgtttaggtagaagaaa
tggggtatgtctgcccttacagtgtgaccttcccaccttctgtcttcagaaccctgtccc
ctccaccccagatagccctgtgccctctggaatccacaggctggcccctcagtagcctcc
ctaccttgcagttgggtggggggtgggaggaggtcaagaaagaggaagtgaaaaccaaat
acaagggctacagagaagtccggtccacaaacctcaatgtttcagcagcacacgctgtga
gaaaggaatgtgcaagctgtttgtggagcatgccttgggggtgccaaggccactggtgca
aaggtgtgcttctggacataagtcactccacacaatgctcaccccaaccctgtgaggtac
ggtactgtcatccccatgtcacagaatgaagacactgagctgcacggacattgagtgtct
gtcaatacagtgcaatggttaatagcatgggatctaggtc
>IGR2058a
tttgtggagcatgccttgggggtgccaaggccactggtgcaaaggtgtgcttctggacat
aagtcactccacacaatgctcaccccaaccctgtgaggtacggtactgtcatccccatgt
cacagaatgaagacactgagctgcacggacattgagtgtctgtcaatacagtgcaatggt
taatagcatgggatctaggtctgtttaaattgggtttaaattctgacttccccacttact
agtggtgcagtcacctgggccattactgacttcctttggtgtcagtttctgcacctgtaa
aatggggctaattggctcacagggttgttgagagaggtaaaagatgtaatgtgtagaagg
agcttagtcaagtgccaagcacaagggagaacccagtggaactaaaatgagcagagctat
gaaatgatgaccattatagagttcaaggttgacagggtggaatggggggttgtcctggca
agctgggaccaggccaccaaggtgctggtttggtgctatgtgagaatggaatgctggcca
ggtggactctgaaacatggacacctggacagtcctcccactgaccttgtccacctttgtc
cggagctctctacctatctgtggctgcttccaaggacggtgatttctgacagaggcagct
ggaccttggcacatgcagaagtttcagctcagcatcagtg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-103
>IGR2059a
aggtgctggtttggtgctatgtgagaatggaatgctggccaggtggactctgaaacatgg
acacctggacagtcctcccactgaccttgtccacctttgtccggagctctctacctatct
gtggctgcttccaaggacggtgatttctgacagaggcagctggaccttggcacatgcaga
agtttcagctcagcatcagtgctggccttcaggaggccgcattggcaggcggcagcagtg
acagccaatgggcagcaaagcttgttgctaaggtcactgtgagccttatttggtgacaca
gggctgaccctgcattcacctctgagaaccctgggaaacgccaaccacagatgtgaaata
tgaacatctcaaaaccacaactgcatttcctttgagaaaagattcggctgtcctcctctc
cagcctgcctccctccgctggatgtcttttgtacaatggctcactactgcaagaggcaag
agcctaggctacaagaagagtctgctacaagctagtcctgggcaggcctggacagggaga
gggcaggggctgctgtgcaggcggccccaggaccttcaaggacctccaagacttccgttc
acacccagcagctgccaacccctgcccaggcctcccccaacacagccggagggcctgttc
ctggccccacttcctgcagccttgggaagccggctagctt
>IGR2060a
gtctgctacaagctagtcctgggcaggcctggacagggagagggcaggggctgctgtgca
ggcggccccaggaccttcaaggacctccaagacttccgttcacacccagcagctgccaac
ccctgcccaggcctcccccaacacagccggagggcctgttcctggccccacttcctgcag
ccttgggaagccggctagcttgagaaaggcgtgtggcactcatggaggaagtgggccggc
actggggctctcaccatctgcaccagccacaccgcttcggtgcagcctggagctcaaacg
gttggcggtttcagtttttcacctccctttggtgcatcttccagcttatcattaaataag
taaaactgttgctccaccccagacaaatgtgggagggaagttgtgtcttcaatatttccc
aaataacactcactgctccctcccattcatacagcaccttcgggtctgggagctgtgctc
acatctgccatctcattacatccttgcaaccctggcaaaggtaatgactgagctcacacc
atgtgtcagggacatgaatgaattcacagaattcactgtaattgtccccattttacagaa
gagaaaatgagacagagaaattcagtcattggctcaaggtcatcacataactaggatttt
ctcccagatggctgagttccaaagtctgccctattctctt
>IGR2061a
atccttgcaaccctggcaaaggtaatgactgagctcacaccatgtgtcagggacatgaat
gaattcacagaattcactgtaattgtccccattttacagaagagaaaatgagacagagaa
attcagtcattggctcaaggtcatcacataactaggattttctcccagatggctgagttc
caaagtctgccctattctcttctgctacattgcctccatggcacatacacaagaatgagt
tccatttactgatgagaaagtgaggctgaggtgaaagggtggtgtggggcctgaggtcag
cgttgcttcctcagtccacatctcctcccagaggatggtccaccaacgtccttcatctgc
cctccccctttaaaaaccactgtcagcccggcacggtggctcatgcctgtaatcccagca
ctttgggaggctgaggtgggtggatcacctgaggttgggagttcgagactagcctgagca
acatggagaaaccccgtctctactaaaaacacaaaaattggctgggtgtgatggtgcatg
cctgcaatcccagctactcgggaggctgaggcaggagaattacttgaacccaggaggcag
aggttgcgatgagccgagatcacgccattgcactccagcctgggcaacaagagtgaaact
ccatctcaaaaaacaaacaaacaaacaaacaaaaacactg
>IGR2062a
ctactaaaaacacaaaaattggctgggtgtgatggtgcatgcctgcaatcccagctactc
gggaggctgaggcaggagaattacttgaacccaggaggcagaggttgcgatgagccgaga
tcacgccattgcactccagcctgggcaacaagagtgaaactccatctcaaaaaacaaaca
aacaaacaaacaaaaacactgtcatgcccccaccgccagcttgtctccctttctttttag
gtgtggcccacagagctcagtgccctgcctatctggaagaggctgtgaagcccatctatg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-104-
taggtaacggaggcaaagcaagggctagggagagtgtgccatgtgggacacctcccccta
tcacctccccactgcctgcacacactggggacagtcaaagcattcctcaggctgggggta
ggagctgtgggcggaagagctggggcatctgttcacagaatcctcccctgaagttgctcg
gaggggctgggatgcagtccagacactggggagcctgatgcagacgcctccctggagcac
tgtccttctcttgggctcttcaagcctgccctcactcatgaacacatattttttgtgtgt
acttcctgcatgccaggcactacccaggcactgtggatgcacagtgaacaacacagacca
ggtccacgcgtcacagactttacttccctgagggaggcag
>IGR2063a
cagacactggggagcctgatgcagacgcctccctggagcactgtccttctcttgggctct
tcaagcctgccctcactcatgaacacatattttttgtgtgtacttcctgcatgccaggca
ctacccaggcactgtggatgcacagtgaacaacacagaccaggtccacgcgtcacagact
ttacttccctgagggaggcagacattaggcaaataatcacatggatctctgaaaaacata
gctcctacgagagggtgcaacttcaggggtcttaacctacaaaggagtgtgtgggattag
ggggttagggcagctgttctaaggatgagacatttcaggtgaggagaggaatggggtgga
gttggcagtggggctggttctcggctctccccgactgccctccttccccgcattccagtc
gcttcaggaaatctgccgcttccatgagagcttctttggtggtgtcttccaagctgctac
caagcgatggctttgccagctgttgctttcagtgtttgtgcctgggtgagcacagccggt
atgaaatggcccagattaatcgagagccaggcccctcctaaagtacctctgaaaagagtt
tttcagcataagcatgacattagcttttcctagagaggaaaccacccccggggctgacag
caagcaggccaggcttaaaggaagcaagtgcagcgctggg
>IGR2064a
ctgttgctttcagtgtttgtgcctgggtgagcacagccggtatgaaatggcccagattaa
tcgagagccaggcccctcctaaagtacctctgaaaagagtttttcagcataagcatgaca
ttagcttttcctagagaggaaaccacccccggggctgacagcaagcaggccaggcttaaa
ggaagcaagtgcagcgctggggcccctccatgccctgctgcagacaggacaccctcactg
ccttcccccaacatgctcccccactcccactcctgcttctttctccctgggggactctcc
ttgtggaaaagaaaccccaacagtagggggagcgagtgaaactggaaaatgaaactgtga
tttacagtttcattttccagtttcaatttagaagcagctctgccagctttccagtgcccg
tgcctcagggcatcacagaggagctgaggggcaggaaaaagtgttccagccagcaagcac
cctgctccctgggcaccctcagagggcgggtactggactggtagaacccactgagcaggg
agttgttgcaatgccgattcctggctctccaggctctgaggccgtacgtttgggcccttt
ggtgattctgatgcaggctgtggacctcaccatggcagtcgtggcctcagagaccatcag
aacagctagagcacacctgaggcacggcctcatcctctcc
>IGR2065a
cagagggcgggtactggactggtagaacccactgagcagggagttgttgcaatgccgatt
cctggctctccaggctctgaggccgtacgtttgggccctttggtgattctgatgcaggct
gtggacctcaccatggcagtcgtggcctcagagaccatcagaacagctagagcacacctg
aggcacggcctcatcctctccaagtcacttcctgccacagatgctcgggaagtgctgctt
ctctgtgcagcatctcctgccctcctccatctggtgttggaggcatcttagatgttctct
gggacctgaggtctgtaggaaaccccggctgtggacttcacacaagggtcgctctttccc
acactccaggtttccctttaagctgctaatttgtaacaggcattcatagaaacagaataa
gatagagaaattctattaaaggaacttatgtgcttttgctctgtctgttgctccatttat
ttgcaatttatagcctaatccaagaggatttaaggacaattaaatatttctttcccctca
gtgtgtgtgtgcgagtgcacgtgtaagagtgtgtaggggttgggtcttccaatgtacctt
tgccctggtttgaccgtggggggagagggtgggcaggtctccaggcctgccagatgtaga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-105
cctttcctaatgtctacagcaaatttgttcttcagtgttt
>IGR2066a
ccaagaggatttaaggacaattaaatatttctttcccctcagtgtgtgtgtgcgagtgca
cgtgtaagagtgtgtaggggttgggtcttccaatgtacctttgccctggtttgaccgtgg
ggggagagggtgggcaggtctccaggcctgccagatgtagacctttcctaatgtctacag
caaatttgttcttcagtgtttctagtatcagtttttgatcaatcattaatcaaagttgca
ataaaaagataatcttctcaggactaggctataaaggtcctggctgcaaccttaaaaaac
ccttctgtggaggcctcagagccaagagaaaagggcgatgtgtctgtggctggatttgga
ggtaaatgaacgtgctgtccctctctaattggtgtgcacgaacatgaacttcagtcactt
gcgtggctatggcctctttcttcatctctccctgccaacgaagctggtggtgccctggct
cccaagccaggtggcaaagctggggaaggaggctgtagttgggcccaaatatgggggtct
gggggcacctccacaggttgtgaccactgcagcatgctctggggccaggcctatggcagt
ggaggcaggacagcccccaggaccacagagcccccatagtggagggagccactacttggg
cggctcagctcattcctgctgacttgctgctgtacagggc
>IGR2067a
ctggggaaggaggctgtagttgggcccaaatatgggggtctgggggcacctccacaggtt
gtgaccactgcagcatgctctggggccaggcctatggcagtggaggcaggacagccccca
ggaccacagagcccccatagtggagggagccactacttgggcggctcagctcattcctgc
tgacttgctgctgtacagggcagaggggtgcctgagacaaagaggagacacacttctccc
acgagaaataaagcaagcagctgttcctctcttgggcccagcaggggtcagaggctgtgg
gaccttcactccttccctctcagtggagagggcagatctgctctttggggtgtgagggca
cagcctcctgacaagctggagaagcaggatttaagagctagaatcaacggagaatgtgag
gcccagcatcaggttcaagaagcaaggggatcaaggttgggggggaggcagggagcctga
gcctagcgcagcccagaccaacagactgaggagtccagagagccaacatgctcactcggc
catcgctaagatgtgtagtgtgtgagaaggtgtgagaggtactcgcgtttctctctccaa
ccccttccaacatattattgggtcgtgggtgccatgtttttagtagacacataaaataaa
tgagtattttcagagaagtgcaaccctggaggtgcagggg
>IGR2068a
aacagactgaggagtccagagagccaacatgctcactcggccatcgctaagatgtgtagt
gtgtgagaaggtgtgagaggtactcgcgtttctctctccaaccccttccaacatattatt
gggtcgtgggtgccatgtttttagtagacacataaaataaatgagtattttcagagaagt
gcaaccctggaggtgcaggggagtgaactcagccatgagaaatcattcaaaggattgacc
tatggaacagggatagacttgctctccatggctccagcagggaagcagcagagaggggaa
cctttcctgaaagtccagtgtgacatctgaagacacacacacacacacacacactttttt
gagagagagaacgagaatgaaaagatacacactgatctttcaacagtcgttgtctctacc
tggtgattgcgaatgattttaatttttttcctcttgtgcttacagtattttctaaaatct
ctaaaatacacccaaattactttcttgttatggcaaaatagacataaaatgtctacatcc
attttaaccatttttaagtgcagagttccatagtatgaagtacattctcactgttgtgca
gccatcaccaccatccatctccagaactttttcatcaccctcaacataaactctgcatcc
actaagcagtatctccctgttcttcctccttccagcccct
>IGR2069a
ctttcttgttatggcaaaatagacataaaatgtctacatccattttaaccatttttaagt
gcagagttccatagtatgaagtacattctcactgttgtgcagccatcaccaccatccatc
tccagaactttttcatcaccctcaacataaactctgcatccactaagcagtatctccctg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-106
ttcttcctccttccagcccctggcaaccatccttctactttctgtctctatgaatttcac
tattctaggtacctcatataagtgggatcatctggtatttttccttctgtgtctggctta
tttcacttagcataatgtttttaaggttcatctatgttataacatgtaccagaatttcat
tcctttttaaagctgaattatgttccattgtacgtattcaccatattttgtttatccact
cctcttgtcatggacatctgggttgtttccaccttttggctattgtgaataatactgcta
caaacactggtgtacaaatatcactttgagtccctgctttcaattcttttgggtatattc
ctagaagtggaactgcgggatcatatgataactaagtttttgaggaaccaccacattgtt
ttcaacaaaggctgcatgattttacgttcccaatagcaatgcacaagggtatctatttct
tcacatccttgccaacacttattttcaggttgtttttgtt
>IGR2070a
atcactttgagtccctgctttcaattcttttgggtatattcctagaagtggaactgcggg
atcatatgataactaagtttttgaggaaccaccacattgttttcaacaaaggctgcatga
ttttacgttcccaatagcaatgcacaagggtatctatttcttcacatccttgccaacact
tattttcaggttgtttttgttgttttaaaatagccatcctaacagatgtgaagtggtatc
ttacttattatggttttcatttgcatttccctaatctaaattacgttttaaaatccaatc
ctctctgaattgaaccctttgttctttatttctcaataaaatggaccttgcccccttttt
ttccttctttgtacctatgctctgcattttaaaaaattgtggcaaaatacatataactta
aaactttaccatcttaaccattttcaagtgtagagttcagtattaagtatattcacattg
ttgtgccctaacccaaatatagtatataatggcaaaaagaaacaaaaggctctctaaaga
aaaagaaagccgtgaattcttggaccccagagatgttcacaaacagattggatcaatctc
agcagggactttcattcatcttctgagcatctctgctgggctgggctctgtgccaggcag
ggggctccgaggtgagtgtggcctggactctgcccttggg
>IGR2071 a
tagtatataatggcaaaaagaaacaaaaggctctctaaagaaaaagaaagccgtgaattc
ttggaccccagagatgttcacaaacagattggatcaatctcagcagggactttcattcat
cttctgagcatctctgctgggctgggctctgtgccaggcagggggctccgaggtgagtgt
ggcctggactctgcccttggggttcagcctctgtggggaacagttatacccaagggctgc
tgtgggcacagagggacaccctgttgtgtgggtgcggcattgggaaggggcataagtgag
gtggcacatgagttcaggtgggaaggatgagcagacatgtacatgtgcagagaagggaac
tggcatgtgtggctgggctgtggcagcacacctcacaaccgccattacaggagcatctat
taatcatttatgtctgtctctctacttgattataagctgcatgagagcagggctggtggt
tttgttcactgctgcattgctgccatgcccagcacaggcaagtgtaaaagaaacacttgc
tgaataaatgagtggttgatgacgaggaaaaaggagacatttctttccagaatcttggct
gtaagcagcagacagcatggctgtactccacggggaaggcaggatggcaggaagcattat
acaggtgatggagacaggagcacagcaggagccagtggag
>IGR2072a
ctgccatgcccagcacaggcaagtgtaaaagaaacacttgctgaataaatgagtggttga
tgacgaggaaaaaggagacatttctttccagaatcttggctgtaagcagcagacagcatg
gctgtactccacggggaaggcaggatggcaggaagcattatacaggtgatggagacagga
gcacagcaggagccagtggagaagaagagtttgaagattccctggttgagagaatggaag
ggcgtaattgctggggagaggtccctgaagaaaggggagaggctgggatgcaggctcagt
ggaaggagaggagtctccttatgagactcagatggccagtgtgaaaaagacagaagatac
caactgctggtaagaatgggaagcacactgcatggggaactctcctatactgctggaggc
gtgttcttcctgttattctagattcagacagcactctggtcgctggttggtgcaggccac
catttgggccaattagaggaaccccaatatctgcacttggactatcagaaatgagagctc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-107
tacgcccagagcaatttccaagatgggcctgaatccatgagtcatggcactaaatggagc
ccagggttggctctgagcctaacagcctccaaaatgtcaactttgttcacgtgccacttt
gtccctcatctcatgccatgcagctggcaggacttcagtt
>IGR2073a
aaccccaatatctgcacttggactatcagaaatgagagctctacgcccagagcaatttcc
aagatgggcctgaatccatgagtcatggcactaaatggagcccagggttggctctgagcc
taacagcctccaaaatgtcaactttgttcacgtgccactttgtccctcatctcatgccat
gcagctggcaggacttcagttgacagaaggtagaccctgctcttttcaaaaagcacacag
gacaggtgctgataggccagcccctcccactgagctctagttactgcggtgaacttcacc
aggaggttcagcacccactgtggctctgcctgaggggcctctgtgcacactcagtccagg
cactagcatcccagcgcccggccagtggtccaactccagactcactacacagagcccctt
gcaaccgatgtgtgccaacatggagcccacacagggcagctcagcgtgacacctgcacag
ctcaagactgagggaaggaaatgcatcttctttctcaagttggaagaggctgtactgaat
taccaaatggcattatactctctgtgggggagcacagatgagtgtccggcagtccctggg
atgatgttacagtccagaggtggggatgagatgagcccagatgatgcaatggggatgcaa
tcaagacacgatgtcattagaagccacagtgtgttctctc
>IGR2074a
aatgcatcttctttctcaagttggaagaggctgtactgaattaccaaatggcattatact
ctctgtgggggagcacagatgagtgtccggcagtccctgggatgatgttacagtccagag
gtggggatgagatgagcccagatgatgcaatggggatgcaatcaagacacgatgtcatta
gaagccacagtgtgttctctcatgccacgtgtttcccagcttagaggagtaaggggtcaa
ggagggggggggtggccccctgggaccctgctctaggacgcatgcataaggacccacatg
caaacgcacagaattcaagagctagccaggcctggacccatgtaggagagccccactggc
tgatttccaatctgggacaaaggccacagacaggaggcctcccttggccacacccaggtc
cccagaacatatgctccactgtccccagtctaaccacaaccccatatgagctgtgtccca
ttcatgttggcctagaaactgggaagtacctggcatggggccctccgcttcctccccatg
actgcctggagctctggggagaccaccaaggggccatttttgtggttaggaaatgtctgt
ggcagctgtggacaccacaggccctccctggacccttctgaagtagaggtcacattccta
aagattcttaactgccagctccaattgcttcttcctgaca
>IGR2075a
tgggaagtacctggcatggggccctccgcttcctccccatgactgcctggagctctgggg
agaccaccaaggggccatttttgtggttaggaaatgtctgtggcagctgtggacaccaca
ggccctccctggacccttctgaagtagaggtcacattcctaaagattcttaactgccagc
tccaattgcttcttcctgacaggctcatcttagtagggagtgaatataatcttttcccag
ttccacgaggtcctctcagatccaaaatgctctaagttcaaaggcaaatcatgaagaaag
ggagacgcagatactaatttgtggttttagttcagtggttttccaccttggctacacagt
agagttacctaaggagctttttaaaaatactcatgtccaaatattccaacaggcactttg
caaagagaagatctaaatggctaacaaacatatgaaaggttgctcagctgtattagtcat
cagggaaatgcaaattcaaaccacactgtgataccactacatacctgccagaatggctaa
catgaaaaagatagaaaatatctatggttggcaaaaatgtgaagcaaccagaactctcat
acattgctggagggagtgtaaatgggtacagccacctgggaacattatttggcataaggt
actaaagctgaacatactcatatccatgcttccccagcaa
>IGR2076a
accacactgtgataccactacatacctgccagaatggctaacatgaaaaagatagaaaat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-108
atctatggttggcaaaaatgtgaagcaaccagaactctcatacattgctggagggagtgt
aaatgggtacagccacctgggaacattatttggcataaggtactaaagctgaacatactc
atatccatgcttccccagcaatggatatacatgtactccaaaaatacacactagcatgtc
attgcaatagtcagaatagttccgaattataaataacaactcgaatatccaaaaatgcat
cacagtagaatggataaatcgaggaatatccatagagtggaatactctatagcaagaaga
gtgaataaactgcagctctaagtaacaacttggatgaatcatctcacaaacacaacaaga
ggatatatactgcctgattccatttacatcatataaagtttgaaaacaggagaaatgact
gtacaccattagaagccagaatggacattagcctttggagccaggtagtaagtggaaggg
gtaccaggggttgctggtgatgttctgtttcatgatttggatgctggttactcggggtaa
attcattttgtgaaaattcactgagctttacacttatggtttgtgctttttttttttttt
tgcatatatgtcatccttcaacaaacacttaaaaaatgtt
>IGR2077a
aatggacattagcctttggagccaggtagtaagtggaaggggtaccaggggttgctggtg
atgttctgtttcatgatttggatgctggttactcggggtaaattcattttgtgaaaattc
actgagctttacacttatggtttgtgctttttttttttttttgcatatatgtcatccttc
aacaaacacttaaaaaatgtttgaaaaccccatcaattcagtcagactctttgggtggga
gcaagatccaggcatcagtattttttaatatcccagatgatggtaatatgcagccaggat
ttaaagtcactggtttaatatcttgggaaaagcagatccactcaagacctcacagggtcc
tgacaaaggccacttccagctcagtggagtgagacactggggtgggaagatgtccatttt
ttggatgtgggtcagtctcttgcacaggcagaggtattgcagcatgctgttgtaatgtgt
atcttccttggcagtgtctgttgaaagctggttgcatcagritgtaatggggtgtaatgg
caacaaggtgggcccagccccccccaggaagtggatcactgagcacagcttctacagggc
catttgtagagaggtggcagctgggcttcccaggggctgccacccagggcagagccagtg
ctgaggctctgacaacctcggcagggtggggagaaggcca
>IGR2078a
gttgaaagctggttgcatcagtttgtaatggggtgtaatggcaacaaggtgggcccagcc
ccccccaggaagtggatcactgagcacagcttctacagggccatttgtagagaggtggca
gctgggcttcccaggggctgccacccagggcagagccagtgctgaggctctgacaacctc
ggcagggtggggagaaggccagactcagggtgtttatgtttgtgggtaatgacagtcagc
tctgggctccagatgatgcttactccctggcctctgtgttcagattaggaacttgcaaca
tcttgctgaggaccatgtcaggctcagctctaagtgctgtggctgagaattttccttcct
ctctgtgtggttagtggcagcctccctagcaatggctgacctctagcatactctgtcaaa
ctacaggcagctgggacaagacaggacatggggctcacagacaggtattccacaacctgg
gccctgtcaaccctcccagaaatgcatgggccatgaacctcctgctgtgggaggggcagt
gcagagaagtctcaataagcttctcttggccctctgggatctccaccatccacagtgtgt
agggctgagctgcaggctgggtcttcaggtggtgtccctgcacatctgctttgcagcgtg
gcgtctatagagcaagagtgaacaggaaggggcctcgggc
>IGR2079a
aaatgcatgggccatgaacctcctgctgtgggaggggcagtgcagagaagtctcaataag
cttctcttggccctctgggatctccaccatccacagtgtgtagggctgagctgcaggctg
ggtcttcaggtggtgtccctgcacatctgctttgcagcgtggcgtctatagagcaagagt
gaacaggaaggggcctcgggcctcctgtagctctgctgggcagggacgctgcggggcctc
agctgggcttccttggctaaagggcacagagtggcgtaggctgcaagaggacaagctaag
ctgatgaaggctctatcactcaagggtagccatgtaaaaaaaaatccctacaggtaaaag
aagcatgaataagacaggcggggcataacagtgtctccccactgaagctgcaactctctg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-109-
cttcactggcttcagcctcctctctgtgaaatgggggcaatgtcccctaggccttttcct
cctgtccagtagggctgagggtctacaggccagagggaggcctgggctctgaggcctgtg
cctgtgtggcctctggctgggacctcagcccccatgtgccatgtcacctcccttgtctgt
gaaataccacaacagcagctcttgccagccagtgacactaccccttcctgttgtcttctt
tacaaagcatttatgaaatgcttccttttcatgcttcagg
>IGR2080a
ggtctacaggccagagggaggcctgggctctgaggcctgtgcctgtgtggcctctggctg
ggacctcagcccccatgtgccatgtcacctcccttgtctgtgaaataccacaacagcagc
tcttgccagccagtgacactaccccttcctgttgtcttctttacaaagcatttatgaaat
gcttccttttcatgcttcaggaaaccggtggccaggaggagttcttgatttcattttctt
ccctagagatatgtgtgcttcgaaatacacaaattaaacaaaaacgagggctgactggga
ccaggagagtgagtgatcctggcttcccttgatttacatgcttattttccttctcaaatc
actccagtaagtacagaagtcactaatctattgccctctattatctgcattatagttaaa
aacatcgacatgaacaaacaaaagcccttgcgtagcctagagaagtcacaaagctcacac
ccagactctcgcctaagagagtctctcagggctcactcagggactatttattcttgtttt
atttttttaaatgttgataccctctctgcttgagtatccttgttttagatgcaaatcaga
aaaggttgctgtattgatcacagtcccagcaggaaacaaatgcacactccactggtaaca
ggagagactgaggaaaggaccgtttccaagggtgagcaag
>IGR2081a
agtctctcagggctcactcagggactatttattcttgttttatttttttaaatgttgata
ccctctctgcttgagtatccttgttttagatgcaaatcagaaaaggttgctgtattgatc
acagtcccagcaggaaacaaatgcacactccactggtaacaggagagactgaggaaagga
ccgtttccaagggtgagcaagatgaagagaaaccctcaaggaaaggtgaagcatcctgca
gccagcaacagtgggagctgtgaccaccaatccccagggaggaggtgggagggctcctgg
aacccagagagacctgtaggaggggactgccggcaggagctgtggttttagggtgaaaaa
cacaggcactattgacctgagacctggcaagggagggagctggggggataaagcacctcc
catttcccctcccagcctccaacctctggtcaggggaggggtcttcaattggccaaaccc
aactggaagcttggggacctggagcctggctgatggaatccacaaaggtcaaatcctggg
aggagtgggaaagagcagaaaatcaactggagcagggatgtgtgggggggtggcaaacaa
acaatgcccggcagagtcaccagggctggccatttgaaaagagtacatcagaagctaacg
tgctgtaatgtggcactctcaccacaaatacataggatga
>IGR2082a
tggagcctggctgatggaatccacaaaggtcaaatcctgggaggagtgggaaagagcaga
aaatcaactggagcagggatgtgtgggggggtggcaaacaaacaatgcccggcagagtca
ccagggctggccatttgaaaagagtacatcagaagctaacgtgctgtaatgtggcactct
caccacaaatacataggatgaaaggcagccagggacagaggcggccacgaagaaaggttt
aaagaatcccagcaaaatgactggggtcctcattatggaagaacaaatagctttacttaa
taattccaaggtaatagcttaatagcttaataattccaaggtaaacaagtattttcataa
ggaggactctgaatgatcaacagaaggttaaatgtcactgtactgcttcacagagctgtt
acagggcagggaagactataacacaatgtagagatagatccatacaagagaggtacaaca
gggtttccagttcaacacatcagttatttacactcctagtttcctttctctcctgaagca
ccactaaaatgctagtctagaaatcaaatggggccaggtgcagtggctcacgcctataat
tccagcactttggtaggccaaggcaggaggatcattagagtccagaagttcaagaccagc
ctgggcaacatagcaagaccctgtcttaaaaaaaaaattg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-110
>IGR2083a
tcagttatttacactcctagtttcctttctctcctgaagcaccactaaaatgctagtcta
gaaatcaaatggggccaggtgcagtggctcacgcctataattccagcactttggtaggcc
aaggcaggaggatcattagagtccagaagttcaagaccagcctgggcaacatagcaagac
cctgtcttaaaaaaaaaattggctgggtgtggtggtgtgtacctggagtctcagctactc
aggaggctgaggtgggaggatcacttgagcccaggagtttgaggctgcagtgagctatgg
tcacaccactgtactccagtctgggcgatgaagtgataccctgtctcttaaaaaaatcaa
atggggccaggcgcggtggctcatgcctgtaatcccagcactttaggaggatgaggaggg
tggattacttgagatcagaagttcgagaccagcttggccaacatggtgaaaccccgactc
tactaaaaatacgaaaagtagtcaggcatggtggcacatgcctgtagtcccaggtactcg
ggaggctgagatatgagaattgcttgaacccgggaggcagaggttgcaatgagccaagat
tgtgccactgcactccagcttgggtgacaaggcgagactctgtctcaaacaaccaaccaa
ccaaccaaatggtattaactctcaaaggcaaagagaatgg
>IGR2084a
agtcaggcatggtggcacatgcctgtagtcccaggtactcgggaggctgagatatgagaa
ttgcttgaacccgggaggcagaggttgcaatgagccaagattgtgccactgcactccagc
ttgggtgacaaggcgagactctgtctcaaacaaccaaccaaccaaccaaatggtattaac
tctcaaaggcaaagagaatggtaaaggagacatgagtggctgaaagagttccccaaacta
caggaagctgggaggcaggtggaggaataatgactgacatggaggaagctaggctctgaa
gggcttgcagaggggcacactgacaggaggcaagccactttacccctggaaccctgcagg
aggagctcagacttggggagtccaggtgttgtggctggtggggctgaggtacagcagcca
gtgggggtaatgaatggaggaaactggttgaaatcctccccaggtctcacctccacaccc
tgccccacacagctggagacaaagacactgaacaggagagagacaggcaggagggagggc
agatgaatacagggatgaaaacagggaggtgagggaaaagtctgaagaatgaagcgtggg
actcaatgtcccacccacttaccttgccccgccccaccccaggtatatatcactctggat
gagggtatggtgaatttaaaagatggttgcaaattctttg
>IGR2085a
caaagacactgaacaggagagagacaggcaggagggagggcagatgaatacagggatgaa
aacagggaggtgagggaaaagtctgaagaatgaagcgtgggactcaatgtcccacccact
taccttgccccgccccaccccaggtatatatcactctggatgagggtatggtgaatttaa
aagatggttgcaaattctttgacatttctccaatggagaggtgggtctgtgtctccttcc
ttgaacctatgtggatttctgactacagtggaaatgagctatgtgacttccaaggctggg
acatacacagccatgcagcttctgtcttgctggccagaacactcacaccagagacttgag
gtgcctcgtaagaggtccaatgaccaggccatggtgctggagacatcatgtgtagtctct
ctggtcaacagtcccaactgagcccagccttccagctctctttgccaagtgaacaaccat
cttacaagtggacccttcagccccagctgttccaactcccagttattccagtcacctcga
gtcattccagtcatcctagccgtcgtagagcagagaattgcccttctgactccttgacag
tggcccaaaaaatggttgttgttttatgctactaagttttgaggtggtttgttatgtagc
gttcaataactagaactaggagttagaatgcttctcttga
>IGR2086a
gccccagctgttccaactcccagttattccagtcacctcgagtcattccagtcatcctag
ccgtcgtagagcagagaattgcccttctgactccttgacagtggcccaaaaaatggttgt
tgttttatgctactaagttttgaggtggtttgttatgtagcgttcaataactagaactag
gagttagaatgcttctcttgaggagctgaatggcttcagggtggtggttctcaacagggt
gattttgtcccccaggggacatttggcaatgtttacagacattttggttatcacaactct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-111
gggaggggggttactactggcatttagtaggcagaagtcactggtgctgctaaacattct
acaatgcatgagacagcctctgacaacaaggaattctttggcccaacatgtcactagtac
caaggttaagaaacctagctctagagaaaaggtgctcattggaggcttgttaactaaaag
actgtcttgcttcctgtagtgaaaccccagttgataaattctccccaagcagagtttagt
tcagccttttattgctccattaataaataccaacagatagctgagatatttggcatttaa
ggaaagcctccaacaaggagagatggagagacagagagagggagaagaaaaagaaagcag
aaggaaaaaggaagaaggattaaagaagagggaagaagaa
>IGR2087a
tgaaaccccagttgataaattctccccaagcagagtttagttcagccttttattgctcca
ttaataaataccaacagatagctgagatatttggcatttaaggaaagcctccaacaagga
gagatggagagacagagagagggagaagaaaaagaaagcagaaggaaaa.aggaagaagga
ttaaagaagagggaagaagaagaacaagaggaagaggaggaggaagaagaagaagaagaa
gaaggatgacgacaacgacaacaacaacaacaacaagaagcagccaccaccgccgctgcc
acctccaggtagaaacaaaaacaaaatagagactagaagactattaagacaaatggacaa
atgaaaaataaatagtgcctcaagaagaataggatggagatagtatatgcataaaaaaga
atgtggtatttttgaaaaagaacaggaagaacaagaatgagtactaggatattagaaaaa
gaaagccaaaattaaaaaaaaaaatcaacagaagggttggagtatgaagtcaatgaaggt
ttcccaagaaagtagaccaaaaaggcaaagagatgaaaagtaggagagaaaatataagga
aactaaaacattaatccagatgatccaacagataaaatacagggaagaaaattattaaag
aaataatacaagaaaatcttccaggactcaaagatgctac
>IGR2088a
aaaaatcaacagaagggttggagtatgaagtcaatgaaggtttcccaagaaagtagacca
aaaaggcaaagagatgaaaagtaggagagaaaatataaggaaactaaaacattaatccag
atgatccaacagataaaatacagggaagaaaattattaaagaaataatacaagaaaatct
tccaggactcaaagatgctacataactcagcagtgacgaatatgtccacattcactattg
agttaaccacagattgtgttatgttcctattggaaggatggagagaggaaaagtggggat
ggttctgtaggaaagttcaatcctcatctatcacaagaagtcaacaaatgcctaaaatcg
gtagatcaaaaaatagtataaacagaaatggaaactagtaaatggttgaaagaggcagcc
tatagagagggggagtgagaaaggcggggaagggatttttattatgggcttctcagtaca
actgatatttaaaccatatgcatgcattattttttattttgtttttaatggatacataat
aattgtagatatttatgcagtgcagtgtgatgtttccagacatacatatagcatgacatg
atcaaatcagggtaattagcatatctatcaccttaaacacttgtcatttctttgtggtga
caacattcaaaatcatctcttccagctattttgaatttgt
>IGR2089a
gcatgcattattttttattttgtttttaatggatacataataattgtagatatttatgca
gtgcagtgtgatgtttccagacatacatatagcatgacatgatcaaatcagggtaattag
catatctatcaccttaaacacttgtcatttctttgtggtgacaacattcaaaatcatctc
ttccagctattttgaatttgtgcattattttgataaatttgatagaatagaaattaattt
aaaagggtacaattttaaaactgcaatgtgatgggatcaaatttaataatttggaaaatt
cgcttatgtagaagagtcatgcctctctaagaatgctcaatgaactggcataggtgggca
caagcaccatcagcatggaagggttcctcctgatgtcactggccactaaggcagttggtg
gggtgagggtggggatgagagccaggcatggcagcccttaggtggtcaccatttccctct
cctggcagcctgtatttgcttgggagacctatctcttgggtatagatcctattgggctgc
taaagaagagaggtgctaatccttttaggatgacttctgggaattcaccaggatgccctg
cctctcctactctggacatggaaaaaaatgctgggtttaccaaaggtggatgagtcaggc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-112
ccaggactagagccacggggcctctccctggacgtgccat
>IGR2090a
ttgggagacctatctcttgggtatagatcctattgggctgctaaagaagagaggtgctaa
tccttttaggatgacttctgggaattcaccaggatgccctgcctctcctactctggacat
ggaaaaaaatgctgggtttaccaaaggtggatgagtcaggcccaggactagagccacggg
gcctctccctggacgtgccatagtcaggctgtctcggcagctaaaagaggctacacacat
ttattgtcatcagaagctgggacagatgagccttgggttacaagatctcctacctggagc
tctcccgggaggtgccaatcataggggatgggaggacaaacacatgcttggtggggctcc
agcgttaccgccgaggtgcatctccttggccactagccctggggtctgacctccccttct
cttttccttcacccattgttctccctattccctttctttcccacctctctctcagttctc
cagagctctgtgcagggactacttagcaaacttacctgctgaaatgcactgttttttttt
ttaaccttttaaattgtcacttttttttaaactataccatccttagataagcaggagata
ttccttgtagaaaaataagaaaatattaataatcacccatgattctatcagtcagaaaac
tccactgctggtgtatgaatttccagaatgtttccaggct
>IGR2091 a
tacttagcaaacttacctgctgaaatgcactgtttttttttttaaccttttaaattgtca
cttttttttaaactataccatccttagataagcaggagatattccttgtagaaaaataag
aaaatattaataatcacccatgattctatcagtcagaaaactccactgctggtgtatgaa
tttccagaatgtttccaggcttataaacgggtaaaaatactatcacagtccatgtctcat
ctaagcacccagctactgagcaatcatcacctactgggctgtgctgaggcctttagatgt
gttaatctctcttaatccttccaacttcacaagataggtgttattgtgccccgtttacag
gcaggaaacaagttcagggagatcacattaattgcctgagttcccaagttggttaagaga
ctaagctagatctcaacccttcaggctgaatccaaagctactttccttgaatggtttgta
agatttttccatttcttttttaaaaaaatggtatgttcaaatatctttctcatcaataaa
tatttatcttcatcattcttcctaatgacattcccttgtatgaatgtgccaatgtggaat
aaccagttccgtcttgttgggctttcagatgttttctttttgtaaatgataaacaatgca
gttataactatctttatatataaactttgcaatagtatga
>IGR2092a
ttaaaaaaatggtatgttcaaatatctttctcatcaataaatatttatcttcatcattct
tcctaatgacattcccttgtatgaatgtgccaatgtggaataaccagttccgtcttgttg
ggctttcagatgttttctttttgtaaatgataaacaatgcagttataactatctttatat
ataaactttgcaatagtatgagtattttcctagaataaatactggaaagtgaaattgcgt
ggtcaaaggccagacacatttttaaaagctgcctctttcccaatcacacatttcccacat
ccatttatttgctgaggatcttcacaaaatttggactgagattaaacacagaatcagaga
agccctatgctggaaagatcttagtatatacctcttgaactaaaccagtcttactttaga
aaaaaaaaaaaaaaaggccaggcgcggtggctcatgcctgtaatcccagcactttgggag
gccgaggtgggcggatcatgaggtcaagagattgagaccatcctggccaacatggtgaaa
ccccatctctattacaaatacaaaaattggctgggcgtggtggcgtgtgcctgtagtccc
agctacttgggaggctgaggcggaagaatcgcttgaacccgggaggcagaggttgcactg
agccgagattgtgccactgcgcttcagtctggcgacagag
>IGR2093 a
gaggtcaagagattgagaccatcctggccaacatggtgaaaccccatctctattacaaat
acaaaaattggctgggcgtggtggcgtgtgcctgtagtcccagctacttgggaggctgag
gcggaagaatcgcttgaacccgggaggcagaggttgcactgagccgagattgtgccactg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-113
cgcttcagtctggcgacagagcgagactccatctcagaaaaaaaaaaaagccctagaccc
tctgcagcagcctgctgtgccttcagtgggccaggcagcacttctgggcaagtgaggaaa
gggagacccggagggaggtagggaagtgagggcaagagggccatgctgtgggcccacaac
caactggcttgggggaggctgctacattttcccaagtgcaacactgtcttcctgagtcta
aagacctcacagccatcactgactatactgagctgcctcactgtccccaggactctcact
ctatccaggaagtcaacgcaaagtctcttgggccttccctttatccagctgccaacactt
agcaccctggtcttccttggacagtttccaaggctacgttgggcagtcccaaacaagatg
tggtcttattgttgtcttaccttggtgtgttttcctccaataggctacaaactctggcac
ctgcaaaaaacaaggaaagtaaatgattgaagcagggcac
>IGR2094a
aaagtctcttgggccttccctttatccagctgccaacacttagcaccctggtcttccttg
gacagtttccaaggctacgttgggcagtcccaaacaagatgtggtcttattgttgtctta
ccttggtgtgttttcctccaataggctacaaactctggcacctgcaaaaaacaaggaaag
taaatgattgaagcagggcactgaaggtgggcctttgaacaacgcaagcctggatggaag
ttgaaagatgagagcccatctgtggtgagttctttgaaagctgctgaggtgtgagttggt
aggatgctggcccagggcagacacgggcacaagcttccacccagcggcattctccactca
gagggtttctttctcatttggcctgttaatgctcctatactggcagaaacctcagtgccc
ttcccactttgtctcaaggccttgtataaaaaataagttgtcccttcattcatttccatg
gatatatccattcatcagctatttactgagcacctactatatgccaggcactgtcctagg
gctctgggaatagagcattggactaaaaaggctaacaccctgccctcatggagcttgaag
tctactgggtaggggggtggggcggtggtggtagtgaagagtccaaaaactaacaagata
cataaattaaaaatataggaatcagaagtggtaaatccta
>IGR2095a
tatttactgagcacctactatatgccaggcactgtcctagggctctgggaatagagcatt
ggactaaaaaggctaacaccctgccctcatggagcttgaagtctactgggtaggggggtg
gggcggtggtggtagtgaagagtccaaaaactaacaagatacataaattaaaaatatagg
aatcagaagtggtaaatcctagggaggaaaaaataaggcaggagagagaggtaaggaata
ttggggcagaaggtgagaaggcgtgtaaaaattctaaaatgtgtgtccagagaaggctag
acacctgagaaggtaaattatgaacaaagttacctgaaaaaagtgaggacatgagccctg
agaattaacggggaagaagcttcccaggtggagggaatggcaagtgcaacagcctggcag
cgagggcctgtctgacatgttaacagataagtgaggagggtggtgtagccagagtagaga
gaataagggagaagcaggagagggatcagagaggtagcgagaggctccacagtgttcacg
gcattcaagggaggtccttgtgtgaacttgggctctgattctgagacaggagccactaga
gggttttttacagagaagtgacatgatgtaactcacattttaacaggatcactctggatg
ctgtgttgagaataaactgagagaaagagtagaaccagtt
>IGR2096a
gagggatcagagaggtagcgagaggctccacagtgttcacggcattcaagggaggtcctt
gtgtgaacttgggctctgattctgagacaggagccactagagggttttttacagagaagt
gacatgatgtaactcacattttaacaggatcactctggatgctgtgttgagaataaactg
agagaaagagtagaaccagttaggaggctatggcagaaatcttggcaagagacaatggtg,
gcttggaccagagcagtagcatggaggatttgctgatggattggaagtgagagattaaaa
agaatgggtttagaacctgactggggcaggttaaaaagaaaggagctgaagctgtgaact
aggagacagagttggctgggagcagcaggaagattcccagttttggcctgagcaactggg
aggatggaattgccattttctgaatggaagcgtacagatggagcatgttttgtggggaga
taaggaatacggttttggacgtaagtgtgagatgccttttaagcacttaagtggagaaga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-114
ctgtaggcaggtggaactgtgaatctggggagaggtccaggctggaaatgagtatttgtg
agttctcagcacatagttctttaaagctgtgacacaggatgagatcatcaagagggtgga
tgtcaatagggaagctgtcggccgggtgcggtggctcacg
>IGR2097a
cgtaagtgtgagatgccttttaagcacttaagtggagaagactgtaggcaggtggaactg
tgaatctggggagaggtccaggctggaaatgagtatttgtgagttctcagcacatagttc
tttaaagctgtgacacaggatgagatcatcaagagggtggatgtcaatagggaagctgtc
ggccgggtgcggtggctcacgcctgtaatcccagcactttgggaggccaaggcgggtgga
tcacctgaggtcaggagttcgagaccagcctggccaacctggtgaaaccccgtctctact
aaaaatacaaaaattagctgggtgtggtggcaggtgcctgtaaccccagatactcaggag
gatgaagcaggagaatcacttgaacccaggaagcagaggttgcagtgagcggagattgtg
ccattgtactccagcctgggtgacagagcaagactctgtctcaaaaaaaaaaaaaaaaaa
agaaaagaaaagaaaagaaaagaaaaaaaaaaaccagggaagctgtgcaaggggctgagc
cccattcagtagctcagcaaaagagactgaaaaggactagcaagtacagtaggagggaaa
cctggagaaagacttctgaggaggatggcatagtccactgtgatagatcaactatttaat
aatatgaagacagagatttagcatcttggagtcacaggtg
>IGR2098a
aagaaaaaaaaaaaccagggaagctgtgcaaggggctgagccccattcagtagctcagca
aaagagactgaaaaggactagcaagtacagtaggagggaaacctggagaaagacttctga
ggaggatggcatagtccactgtgatagatcaactatttaataatatgaagacagagattt
agcatcttggagtcacaggtgatcctggtcagggatgattcagtggaacagttggagtga
gaatctgactacagcaggttctaaagagaggagctgaatttgggagctgagggatggagt
tggctggtgacagcaggagggctggaagcagagggagagggatctaacctacattggttc
caccttaagagaaaacacaaagctggtacttcctcaacacctgtacgtggccgctgttgt
tactaacactgggccaggtcctccagcttgctgagcaccacccaggtctggtcctataag
ctagctctccacctgtttctagattcctatgaagttatttcctttttctcactgctgtgt
gtagccttaggataaatgcccatagcttggggctgctgagcaagtcctcagttgcttgtt
gaccaagatctggcttgggtcctttctcctaatgggaagtcagagtgagcaagggactct
gctcttggatagcttgccttctgtgcaggagataaataat
>IGR2099a
tagattcctatgaagttatttcctttttctcactgctgtgtgtagccttaggataaatgc
ccatagcttggggctgctgagcaagtcctcagttgcttgttgaccaagatctggcttggg
tcctttctcctaatgggaagtcagagtgagcaagggactctgctcttggatagcttgcct
tctgtgcaggagataaataatcaccaaggaaatggatatgcaggcaggtaacttcagatg
cagatgggtgctatgaagacagtaagctggggtgaaacacacagagtaagtgtgggagcg
acctcctttcgccaggctgtgtggtcaggtgcctctctgggaggtgacatttaggatgac
acctagacagcgatgcccagcttattctcctcaagctggcctctcctctgctgctcccag
ccttccccgtggcttctacaatatctgcactctgggaacaaggccaaggccttgggccat
ctaagtgcaaagccaaa aggaaacaatcctcttctctcgccaatacacaccatgggaact
ttttctccatgattacaaaatacgtgcattttcactgaaggaaacttggaaatattgaaa
acaggagaaaacgtgtcattctactacccagaaataactacaattaactttggatgcatc
cttctagacattcttctatgcatatatataggtatttttt
>IGR21 OOa
gaaacaatcctcttctctcgccaatacacaccatgggaactttttctccatgattacaaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-115
atacgtgcattttcactgaaggaaacttggaaatattgaaaacaggagaaaacgtgtcat
tctactacccagaaataactacaattaactttggatgcatccttctagacattcttctat
gcatatatataggtattttttttcttatttccttgggttaaaaatgagatcatgtacatt
gtgttttatgatctgaattttgactaaatctgttataaagcactcttctcatgaaattaa
ttttcttctacataatgagtttaaatggctgcattaaaagtatttcattatatgtagatt
tttaccatattttatttaattcctaaacattggccatttacattgtttcctatgattgtt
actaccagcaaatgctctaataaacaatcctgtatatttttccttggagaagggggtttg
ccaatctcttatttccttgggttaaaacaaaatgtcactgcccagtggcagtgccatggg
tctcatggcagcctgaggctgagggcatgggagggcaggaatgagccccaagcctaagga
gccactcagatgccagaggctgatttagtcctatgacatgccaggtcttgagttttcctc
ccctgagggcctgatcagtacgaaaacaataggcctctcc
>IGR2101a
ggttaaaacaaaatgtcactgcccagtggcagtgccatgggtctcatggcagcctgaggc
tgagggcatgggagggcaggaatgagccccaagcctaaggagccactcagatgccagagg
ctgatttagtcctatgacatgccaggtcttgagttttcctcccctgagggcctgatcagt
acgaaaacaataggcctctcccataaacccagagaaatccaaggggattccccacctcag
caggaagagggtgtcactctctgaccccagaatagagaccacctccatcctcccttgaaa
tcccctggggaagcttctcctgccctccctccctggggaaaacattggcacggtcaggcc
ttcaatctctctttggggaggggctgccagggaatgctcaggaaacagaaggttccatag
gaatagcagggcctgtcctatccctgacccagccttttccctaaatcctcaaattcccca
caggggctggcagggacagtctatgctccccgtaagaggatgtcctgagggctagtgagt
tctagggtaaggtgggaggccaccagatgagggtttgaatccaggctctgacattccagc
ctcgtcttgggcaagtgacttcacctgtggaatgtgagctacgaggaaggaacttagatt
tgcggcccttagcattcaacaggggctctataaataccag
>IGR2102a
tctatgctccccgtaagaggatgtcctgagggctagtgagttctagggtaaggtgggagg
ccaccagatgagggtttgaatccaggctctgacattccagcctcgtcttgggcaagtgac
ttcacctgtggaatgtgagctacgaggaaggaacttagatttgcggcccttagcattcaa
caggggctctataaataccaggccaggccaatgcatgatcctgtctgagcctcagctgct
catatgtgaaatggatgacacctatctcacaggtttgttgtagggactaaatacaactta
atacagttaacactctactgtttgagaaacattagagtccaaagccctggagggctactt
ccaccacgccccatgctttgtagtctcctctttttggcagaactagtttacctccacact
gctactaccacaccctagacatacctctggtgtagtatgcagcacattgtgtgtgtactt
gtccaactcctccatgaagcttcagggcagttaaagacaagaattttgcctctctatcgt
ctgtgcctctgaatgacactatgaagtaagcaagggcattatttccattctacaaatgag
aaaactgaggcttagaaagattagatgccttgcccaagtcacacagtggagagtaggaga
gcaagacctaaacctggttctcatttctgggcctgtgttc
>IGR2103a
cttcagggcagttaaagacaagaattttgcctctctatcgtctgtgcctctgaatgacac
tatgaagtaagcaagggcattatttccattctacaaatgagaaaactgaggcttagaaag
attagatgccttgcccaagtcacacagtggagagtaggagagcaagacctaaacctggtt
ctcatttctgggcctgtgttctgtaaaccaaaaagaaaattccaaggcaccccccagctg
tctgaatagacccctcctctcggccaagggcattccaaagttaacctgaaaaactagttt
aggccatgatgggaagggggagccagacatgcctcgttataccctcttcccttttggaat
tactgactctttaagactgataagagatatttacagtccattctctctgaagcctgctac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-116
ctggaggcctcatctgcataataaaaccttggtccccatagccccttatcgtaacccaga
cattcctttctgttgctttctattgataataactctttcaaccaattgtcaatcagaaaa
atttttgaatccatctatgacttgaaaccacccccactccccaacctagttgtcctgcct
ttttggacagaaccaatgtacatcttatatgcattgattgatggctatgtctccctaaaa
tgtataaaaccaaattgtggcctgaccactttgggtacat
>IGR2104a
ctattgataataactctttcaaccaattgtcaatcagaaaaatttttgaatccatctatg
acttgaaaccacccccactccccaacctagttgtcctgcctttttggacagaaccaatgt
acatcttatatgcattgattgatggctatgtctccctaaaatgtataaaaccaaattgtg
gcctgaccactttgggtacatgttctcaggatctcctgagggctgtctcacaggccattg
gttacttatatttggctcagaatagatgtcttcaaatattttacagtttgaccgacaact
ctattctagatgattctcttgcaaaagggagttggaggtgagaaggaagtgagccaattc
tcatgtccctgagaaaaaggcaggcagagcttcgagaggaaggaggtgcttggggaggca
gcaggacactgcacttgcctcagccccatcctgactccccgtggatcatcgtgcatgcag
cagctgtgacccccagaggcctctagttcagcataagctgaggcaaagggggcccccagg
ttccctctactggtgtggagcccagccggcaaggggactggggatcggcggcccagagtt
gattgttgtggccccagcagcaggatgatggctgtagagcacctgctcaggagttggcct
atctccagctatggggcgggaaggctccctaccagaccac
>IGR21 OSa
cctctagttcagcataagctgaggcaaagggggcccccaggttccctctactggtgtgga
gcccagccggcaaggggactggggatcggcggcccagagttgattgttgtggccccagca
gcaggatgatggctgtagagcacctgctcaggagttggcctatctccagctatggggcgg
gaaggctccctaccagaccacacacatcttgatgtactcaccctgtgagcccaggacccc
tgtgatacctgctgaggtgaaggctgaatgagtgagagctcccagcctccagcatcaggg
cattagggagaagaagcagctagactcaagccagggatgcagagggagggaacaggcatc
aggtagtaggtgttttaatgtcacctacctcttattatgttgtatgtttctggaggatgg '
gtccatggctgatccatccttgtgtctctactacaaccagcagattactttacagagagt
tgatactcagtaagtacagcttattgaaggtgtaaccaaaagccagtaggcaggatgaca
gatggcatccgccttgcatgtctgggtcatcagggaaagggccaatgtccagtgtgtcct
gaccaggatggttctgacaaggacatccatagcatccacagagggtgctccctccccagg
caacaaactctccctccctcctttctttcttccttccctt
>IGR2106a
cttattgaaggtgtaaccaaaagccagtaggcaggatgacagatggcatccgccttgcat
gtctgggtcatcagggaaagggccaatgtccagtgtgtcctgaccaggatggttctgaca
aggacatccatagcatccacagagggtgctccctccccaggcaacaaactctccctccct
cctttctttcttccttcccttttttttgagatggagtctcacttattgcccaggctggag
tgcagtggcacaatctcggctcattgcaaccttcgcctcctgggttcaattgattctctg
gcctcagcctcccgagtaactgggattacaggcatgtaccaccatacctggctaattttt
gtatttttagtagagataggcttttgccacgttggccaggctggtctcaaactcgtgacc
tcagttgatctgcctgcctgggcctcccaaagtgctgggattacaggcatgagccaccgc
tcccagcacactctccctttcttagccaaagagacaccacttggaggaaactacctggat
ctaggtgcttccctagtgacaaaaatggactggggatgtggtataaatccttgcccctgg
gaatctggaagggacctatgatatgagaaaaaacaaacaaacaaacaaacagaccaatta
tctctttattgagaccaaaactgctgcttttgcctgaatg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-117
>IGR2107a
tcttagccaaagagacaccacttggaggaaactacctggatctaggtgcttccctagtga
caaaaatggactggggatgtggtataaatccttgcccctgggaatctggaagggacctat
gatatgagaaaaaacaaacaaacaaacaaacagaccaattatctctttattgagaccaaa
actgctgcttttgcctgaatggtcagattgactgattcctcttccacttgccatccccac
tgcatgcatggctacaaataatcctgatgttgcacatttaaaatagtgccttgcttcaac
tgcttcagtctatcagtgtaaactgtgtctcccctggcaggtatgctgtgggggacagtg
cagggcttgtctctgtaggaccaaactcagtatgaacttatcacctgcctgtgtgtacag
ctttaagcttcaggtagagggtgttataaaccctggagtaggacttccctagagaacagg
tcattacactatgtccatctattgaggccctaaattaagtctacagaattaggcctaaac
tccgcagacagtagccaaaggtctcaggctctggcccactccacctgtccatccacacct
ccttctcatcttgcccttcactcacttaacacagtgcccaaagggagatgcagttgcctg
gacaggctggctttggcttaagctaggggttcttaaagaa
>IGR2108a
tattgaggccctaaattaagtctacagaattaggcctaaactccgcagacagtagccaaa
ggtctcaggctctggcccactccacctgtccatccacacctccttctcatcttgcccttc
actcacttaacacagtgcccaaagggagatgcagttgcctggacaggctggctttggctt
aagctaggggttcttaaagaatagtccccagaccagcagcatcagcatcacctgggactt
gttagacctcctgaattggaacctgtgggatgagactcagcaaactgttttaatgagtct
tctaggtgattttggttgcactaaagtttgagaaccactgggtgagccattccctgagcc
caggttgcctttctcagccattttctgcctattataatctcaaccacctttcaaagttca
gctcaataccatctcttttgggaagcccccgtagtcccccaagtacttgtgaaggcctct
tccttgaaccgacagcttctttgtcaccccatcccccattctagtgaaagaccttcattt
ctgcttctctttgcagcatgtattttctgctttgttttatagtaaactttgagcagttgt
taactgccttcccacactgattcccctctaacacacaaatgttactctgtaaaggccatg
tcttacttcactcattcttttttattttttatttttgaaa
>IGR2109a
tttgtcaccccatcccccattctagtgaaagaccttcatttctgcttctctttgcagcat
gtattttctgctttgttttatagtaaactttgagcagttgttaactgccttcccacactg
attcccctctaacacacaaatgttactctgtaaaggccatgtcttacttcactcattctt
ttttattttttatttttgaaacaaggtctggctctgttgtccaggctggagtgcagtggc
atgatgttggctcactgcaacctctgactcctgggctcatgtcatcctcccacctcagcc
tcccaagtagctgggattacaggcctgtgctactgcgcccggctaatttttgtattttta
gtagagacagggtttccccatgttggccaggctggtctcggtctagactcaagtgatccg
cccaccttaacctcccaaagtactgggattacaggagtgagccactgcgcctggtgcaat
ttgctcattctttgaataaatgtccactgaggatctgctctacatggcgggggctgtgct
aggcactggggttcagacaaaggtgcacccttatacttatcatccaggagccagtggggt
gaatggcaaggtggctggcaattgcaatactttgagtagcactgagacagaatgcttcca
accacagggggccccctcatgcccctccctgttgggaccc
>IGR21 10a
atgtccactgaggatctgctctacatggcgggggctgtgctaggcactggggttcagaca
aaggtgcacccttatacttatcatccaggagccagtggggtgaatggcaaggtggctggc
aattgcaatactttgagtagcactgagacagaatgcttccaaccacagggggccccctca
tgcccctccctgttgggacccacccaaaaagtaacctctgttctaacttccatcaccaga
gattaattttatctgtttttgccttttgtttgagacagggtcttgttctgtcgtccagga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-118
tggagtgcagtggtgcgatcatagcccagtgcagcctcaaacgcctagactcaagcagtc
ctcccacctcagcctcttgtgtagctaggactacaggcatgtgccaccatgcccagctat
tttttttttttttaaagagacagagtcttgctatgttgcccaggctggtctcaaactcct
ggtctcaagcattcctcctgtcttgacctcccagagtgctgggattacaggtataagcca
ccgcacccggccaattttatttgtttttaaacttcatataaatagaatcatacaatgtac
ctttcgggtgtctggcttcttcccactacacattatctgtgcgatccatgtatgctgtta
tgtatagacacagtttgttcttttttaagattgctgtgtt
>IGR2111 a
gtcttgacctcccagagtgctgggattacaggtataagccaccgcacccggccaatttta
tttgtttttaaacttcatataaatagaatcatacaatgtacctttcgggtgtctggcttc
ttcccactacacattatctgtgcgatccatgtatgctgttatgtatagacacagtttgtt
cttttttaagattgctgtgttgtatcccattgtgtagatatgacacaatttaaccattct
actgttgatggccatttgtgttgtttctagtttggggctcttatggagaaagatactatt
agacataagacaaaaacattttggtttatgtccgctggtggacattctggacattcgcac
tcattcctcttgagtatgtacctagaggtggaactgatggtttatggaatgggtatagtc
ttagctttagtagatactatcaaatagttttccaaagtgattgtaccaatgtacactcct
accagcatataaaagtgtttgccaacatttggtatcatcagtcttcaattttagtccttc
ctgtgggtatagagttgtatcttttacgttttaatttgcttattggctatttatatatcc
acttttaagatgttcctgtttaagacttttgcctatttgcttttttcttatttacttaca
ggaattctttggaccttctggatataagccccagtcgtct
>IGR2112a
tgccaacatttggtatcatcagtcttcaattttagtccttcctgtgggtatagagttgta
tcttttacgttttaatttgcttattggctatttatatatccacttttaagatgttcctgt
ttaagacttttgcctatttgcttttttcttatttacttacaggaattctttggaccttct
ggatataagccccagtcgtctgtcggatatgttacagagaatatcctctcctcttccagt
ctctggctcgcctttccactaggttttttgtttttttttttctgagacagagtctcgctc
tctcacccaggcfggagtgcatggcatgatctcggctcactacaacctccacctcccgag
ttcaagtgattctcctgcctcagcgtcccgggtagctgagactacaggtgcccaccacca
tgcccggctaatctttgtattttcagtagagacgggatttcaccatattggccaggctgg
tctcgaactcctgacttgtgatccgcccatctcagcctcccaaagtgccgggattacagg
tgtgagccaccgcacccagacgcctttccactctttaatggtatttttgatgaacaaaag
ttcataaatgttcaatttacccatcttttcatctatggctagtgtatcctgcttaagtaa
tcttagttccaagaagtccagttaacagaaataacaaaaa
>IGR2113a
gatccgcccatctcagcctcccaaagtgccgggattacaggtgtgagccaccgcacccag
acgcctttccactctttaatggtatttttgatgaacaaaagttcataaatgttcaattta
cccatcttttcatctatggctagtgtatcctgcttaagtaatcttagttccaagaagtcc
agttaacagaaataacaaaaattactaatattaaaaaagacaaagaagtgaaggaaaaaa
ttggatggtgggtgtgggagaaggactgcatcagatcgtgagagtgtgctcacttgactg
tgctgtgcaaagcccgggccttgtcctgtgttgtggtatggatgggagctgaacccccag
gcagtgcaacaaacatgccctctgtttggttcagatgctgcgccaggtggtggaaagggc
tctgtgggctgtagggggaccctggctcaatggcttaagagaaagatcactccttttcat
gtgtgttaagctgggtctgacccccaaaccctggagactccctttagtccaggccctgcg
cctctgtgccagagcctgcaaagacagcagtgctgacacttgtccagctggctcacaaag
gggaaattctcccctccttgagtcaccacatagacaggaggagcttcaaataacaagcgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-119-
tcgactccaaacgatccctatgctcatttcacgatgctgc
>IGR2114a
acccccaaaccctggagactccctttagtccaggccctgcgcctctgtgccagagcctgc
aaagacagcagtgctgacacttgtccagctggctcacaaaggggaaattctcccctcctt
gagtcaccacatagacaggaggagcttcaaataacaagcgctcgactccaaacgatccct
atgctcatttcacgatgctgcatcactttcaaaatcccctgtgatgcttgtgtatgaagt
ctagatccagaaacritccccatgttttccccagtttgagtagaacaataccctgggagt
cacaagctacatcatacaattgacttccctaaaaaaaaaaaaaaaaaaagagatcttgga
ctcaaggttatgagtttgcagtgtcctttgcagggtcttttaaatcccctagtggcatat
gaaactctggatgtttgtgaattttcctggggaaagggtctatgtgtgccatcagattcc
ggaaggggtgtatgacctcaaaaaaaggtaagactcactggaccgagtcccctttaagga
tagtttgcagtcctcttctgctgggaggtgatggtagtaggcttgccaagaggacctcaa
cctaccagatggatgcgatctgccatccacctccccagcataaagccagttcataaagcc
agctccagcatctctggggcagttttcttcccatccaggg
>IGR211 Sa
aaaaaaaggtaagactcactggaccgagtcccctttaaggatagtttgcagtcctcttct
gctgggaggtgatggtagtaggcttgccaagaggacctcaacctaccagatggatgcgat
ctgccatccacctccccagcataaagccagttcataaagccagctccagcatctctgggg
cagttttcttcccatccagggtcaagctcttggcggcttagagatgcagtgtgccagtcc
caacaccatggctgtgtgtcactgcagatgaaggcatactttttttctaggacgtgcagt
gaccccacttggcagcagacactcatttctgatatttttgtatgccaagtcttgggtaaa
acaactaagtgatctcttaaggacccaggttccttttttgtccctgttccttgcccctca
ccaccactttttccatgtgccaccctctcataagaactcagaagcccagggtggagtcaa
aggggtcttttaaatcccctagtggcatatgaaattctggatgtttgtgaattttcctgg
ggaaagggtctatgtgtgccattagattctggaaggggtgtgtgacctcaaaaaaaggtt
aagacccactggaccgagtcctctttaaatggaagtgcatggatcagtttgataaaatta
atttatagtaatgagctatgtatctttagctaactgcact
>IGR2116a
tagtggcatatgaaattctggatgtttgtgaattttcctggggaaagggtctatgtgtgc
cattagattctggaaggggtgtgtgacctcaaaaaaaggttaagacccactggaccgagt
cctctttaaatggaagtgcatggatcagtttgataaaattaatttatagtaatgagctat
gtatctttagctaactgcacttctaaaaagacatctgggaagggagaacgcttaactaaa
attattattataattattattttttgagatggagtattgctcttgtcgcccccaggctgg
agtgcaatggcacgatctcagctcactgcaacctctgcctcccaggttcatgcaattctt
gtgcctcagcctcctgagtagctggaattagaggtgcccaccaccatgcccagctaattt
ttgtatttttagtggagacagggtttcaccatgttgcccaggctggtctttaactcctga
cctcaagtaatctgcccacctcagcctcccaaagtgttgggattataggcatgagccact
gcacctgacctaaaattatatttctaatgacaaaactgaggtacagctcataactaaata
ggggagaatgacattaaagccactcccatcactaaaaaagaccaatttttctggtctaga
tggctttttagaggctcctggagcaggaacaaggggttag
>IGR2117a
ctcagcctcccaaagtgttgggattataggcatgagccactgcacctgacctaaaattat
atttctaatgacaaaactgaggtacagctcataactaaataggggagaatgacattaaag
ccactcccatcactaaaaaagaccaatttttctggtctagatggctttttagaggctcct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-120
ggagcaggaacaaggggttagtgactacgatgtgtcaaaagagacataggcatttctcag
ataaacctcagctcttccggcttgagagaaggaaacattcccaacatgacttaggggccc
aaggaccctgtttccacctcatatcagattgtcaaatgggaagggtgtgcctagggcaca
cactccctcccgaaagggctgagtccccagaagacctatgtctgctccatcctgggtccc
tgctctctcctggagacaagatacagctgcctgtatgagtagcagtctggggcctcctcc
tccctccctctgccccaccccactcctccctgcccgcccccatacacactgggttcttcc
tcccctgctctctctcaagaagccaggcccctgcccccactcacagtcagaaggaagtga
ttctgcaaggcctcccagggactcccaggactggctcaaggcatcagactgttaaataag
tgggattttttcagtgtttgtagaaactgttgtttaaaaa
>IGR2118a
ccactcctccctgcccgcccccatacacactgggttcttcctcccctgctctctctcaag
aagccaggcccctgcccccactcacagtcagaaggaagtgattctgcaaggcctcccagg
gactcccaggactggctcaaggcatcagactgttaaataagtgggattttttcagtgttt
gtagaaactgttgtttaaaaagatgtaaccatccaaactgtttatgtaacccttgggaag
tctcaacagatatggttccctatttataactgtggccaggactttaaaaatacaagtgga
gggggactgtcaaaatcagagaggttgtcacgttacagttgtatgcttgcataactgaat
tcagtattttgctctaatttgagaagtttctttttattcacttttctccttttctggttt
tctcttcctttgttgtccactgctgtgcaccatacactcctgacattttctgagaacatc
agaactatttctctgaagtggaggttcaaaataggggtttttagaatgaccaaataataa
tgaacactaaaattcatttcaaagcctaggactagtctattcatactgatattcctagtc
tacaagggtaaacatagctgtcttctcgccgccagcccctacacctgcaggggcctgctc
tgtctctgggttgtccgctctggaggtaggtgtcagacca
>IGR2119a
ggaggttcaaaataggggtttttagaatgaccaaataataatgaacactaaaattcattt
caaagcctaggactagtctattcatactgatattcctagtctacaagggtaaacatagct
gtcttctcgccgccagcccctacacctgcaggggcctgctctgtctctgggttgtccgct
ctggaggtaggtgtcagaccacctggtctcactttcctaggtccaatctctggatctatg
gcaacagaatccacaggtccctattcccatacagggggaatgcaaagttgctgggggaca
atcacagtgcaaagctgagatctgggcttctttctagagccattctgaggtcttcatcac
tcacactaacaatccaactaaaacctggctcttgtaggaacacatcctcttctttattag
ggaggctgttctctgagttaacatagtagcagtttcgttcacagatctttctggcaaaaa
agaatccgacgagagctatgcctccaccaaaggcacagtttgataacactttggggaagg
atggttcatagctcctgaagaagaaagagtctgtgataagaacctctggcccacaggctt
cttcacactacacaacttccaaaatccctaaccactgctaatagctaggaggaggatagt
gactgttcccaacacaaagagatgacaaacatttgagatg
>IGR2120a
gcctccaccaaaggcacagtttgataacactttggggaaggatggttcatagctcctgaa
gaagaaagagtctgtgataagaacctctggcccacaggcttcttcacactacacaacttc
caaaatccctaaccactgctaatagctaggaggaggatagtgactgttcccaacacaaag
agatgacaaacatttgagatggtggatatgctaattaccctgatgtgatcactatacata
atatgtattgaaacatcattatgtaccttgtaaatatgtataatcattataacacacaat
atgaggtcccagacaatgataatacataataattatacgtttatgggatacatagtgatg
tttcaatatgtataaattgaagtggtgtgaattatgtataaattttaactacattaaaaa
ttacagaaaaataaattttaaaaaacaaaacaaaaaaaattcttaactgctgtcaagcta
gcactgacaaccgaagcctcagcccagtacctccctgcttccacctgtgctgaccaccct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-121
aagagagaaggcagaggcacacagcccttacatcttggtggggaaaccctagggtttcct
ctgagggcctgacagattgaaggggttgaaaatgagtggagggtgtggccacctcagctc
tagcctccttctgctgagggacagtggccaaggaacatcc
>IGR2121a
cagcccagtacctccctgcttccacctgtgctgaccaccctaagagagaaggcagaggca
cacagcccttacatcttggtggggaaaccctagggtttcctctgagggcctgacagattg
aaggggttgaaaatgagtggagggtgtggccacctcagctctagcctccttctgctgagg
gacagtggccaaggaacatcctcatagatccaaaggaaggtggagagtccctctttgtcc
tctccacccacctcatccccaccacgccctgatgtcactccctgctgtacccaccccgga
aacccttagccacttcccacaggtccactcccagggaagttctttaattggtggatgtgg
gaaagaggaagaggaaaaatatcatttctaccttcccaattccctgtatcccatgagcct
ccagtctgaaaatgattacccatctgacctggagctctcatcctaggtatcataatggct
cttcttttacccataaggagaatgggtaatgaagaaatgcaaaatcccaactcatgaaaa
tgtggttgaaaaagggaagacccataaaagttctcatttgttgaccagagacaataaagt
gattacttaaaaaaaaaaaaacccacctctggggtctttccaaatcatggagaaaaataa
aaacaggggaagacatgctctagtcttaaaactccaatgt
>IGR2122a
gaatgggtaatgaagaaatgcaaaatcccaactcatgaaaatgtggttgaaaaagggaag
acccataaaagttctcatttgttgaccagagacaataaagtgattacttaaaaaaaaaaa
aacccacctctggggtctttccaaatcatggagaaaaataaaaacaggggaagacatgct
ctagtcttaaaactccaatgtggccccagactggtgagccccaacaacagtaaataccca
ccctcagcagccttctgcccacctcaccccaccaatactaggtcccagacaagtcaacaa
acacttattgaccatgtactgtgtgcttccaaccattccgggagttggaattctgcaacc
tcaaggtgctttgcgaggagcagggaaacagctcagtcaacatttactgtgtgctgacgt
tttgctaggtttagaggaggcaaaaatctgagaaaaaaacagctaagaatactccaatct
gggaagtactaatatacacatagcaccataggagcaaggaacaattaattctacatggtg
aggtcaaccagagaagatgatttttaagttgggccttgaaagcacattaggattttgctg
ggtataactgggaaggagtggcattccaggcagaaagaactgagtgagcaaaggtcaggg
ttggggttggtatgggcagttggttgtatgtgatacggcg
>IGR2123a
atagcaccataggagcaaggaacaattaattctacatggtgaggtcaaccagagaagatg
atttttaagttgggccttgaaagcacattaggattttgctgggtataactgggaaggagt
ggcattccaggcagaaagaactgagtgagcaaaggtcagggttggggttggtatgggcag
ttggttgtatgtgatacggcgtgtagtcaggccagtgttgccagaacacggggtcagaga
gcaagagcaaaggaggtaaggctaaaaggcaggctgcagtttatggcagccacgaacaca
tgccattcaaaggacctgttgcatggagtgcagacagctgacaggctgcagcctcggatc
cacaccattcaagtcagaccatgttgcctcctgggtggcccccagccaatgacagaacat
ggcagggttgctcgggcctgtccatttctgcccaaagtgcgactcttctcctgggcaatc
tttggctggaactccccactgggctcgttgagacactcttacagccgcatcacagtctga
tgctctttcaacagaattatccttccctctcttgcgtcccagagttagatctggactgca
gtctgaaagctgtcttttctctccgtacttctgctcctttctcctttatctttcataggc
attagctcttcttacccccaataaatcttctgcacttttc
>IGR2124a
tgggctcgttgagacactcttacagccgcatcacagtctgatgctctttcaacagaatta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-122
tccttccctctcttgcgtcccagagttagatctggactgcagtctgaaagctgtcttttc
tctccgtacttctgctcctttctcctttatctttcataggcattagctcttcttaccccc
aataaatcttctgcacttttcattctgttttggtgtctgcttcccagaggactccaactg
agaaggagcttagatgaatgtttgggttttgctgacagtgaggagccactgaggtatttt
aaacagggcaagccatggtcagatctgagtttcataaaagcaattctagcactagggtga
agagccggggggtggggagacagggaagcaacaggcaatgaaaagaccatttaaaaggac
actgcactgattggtacaaggtttcaacaaggggcaactggaagtatatacaacttacta
tgtatataccctttaactcaacagtctcaattgtagaaatctattttatagaaacactag
cacaaatgcataaaagtataaaaatgaggatgtagtggcctataaatattatcaggacat
tgaaaaactttgtggtcatctgtaggggaggagatgaactagcagtacatctacgtggtg
gaatacataccaagcagcctttaaaaagaagacagcaggt
>IGR2125a
aacagtctcaattgtagaaatctattttatagaaacactagcacaaatgcataaaagtat
aaaaatgaggatgtagtggcctataaatattatcaggacattgaaaaactttgtggtcat
ctgtaggggaggagatgaactagcagtacatctacgtggtggaatacataccaagcagcc
tttaaaaagaagacagcaggtctctatgtactgtcatagagaaatatacacaatagactg
ctatttgtaaaaagccggttgctagccgggagtggtggctcacgcctgtaatcccagcac
tttgggagactgaggcgggtggatcacctgaggtcaggagtttgagaccagcctggccaa
catggtgcaaccttgtctctactaaaaatacaaaaattagttgggcgtagtggcgggtgc
ctgtaatcccagctacttgggaggctgaggctggagaatcgcttgaacctgggaggtgga
ggttgcagtgagccaagattgtgtcactgcactccagcctgggcaacagagtgagactct
gtctcaaaaaaaaaaaaaaaaaaaaagccagttgctgtacaaagtatatagcatgctccc
attttcatgaacaaagctgtgcatacgtatatttataaagatccacatttgtttgtataa
ataagtctggaaagagatatatcaactgttgacagaggtc
>IGR2126a
tgtgtcactgcactccagcctgggcaacagagtgagactctgtctcaaaaaaaaaaaaaa
aaaaaaagccagttgctgtacaaagtatatagcatgctcccattttcatgaacaaagctg
tgcatacgtatatttataaagatccacatttgtttgtataaataagtctggaaagagata
tatcaactgttgacagaggtcacctcttgaaggtggtagggctttcactttttactttct
atgttgtttttattttctttggtgcttttctataatatattttctacttcttaaaatgat
gaagatggttcatttctcttatcagaacacaaaattttaatttaaaaagcttcatatcta
cttagaaaaccatataaaaattctttatattgtatttccagagaagaaataacaaaaatc
tcctagaatcgttgagagggctgtcagcggcctggtctcggtaaagagaaattagagatg
agttggaatagagccgaacacagggtggtgaagacagaagttccagaagaagccaagagt
gctatcttgagtagtgggcaggtgacccacagaagggcggtgggtgggaagtaggagtga
gaggggtctgtgctgaatgtgccagccttcaggaggctcaggccaggacagggtgtataa
acaagaggtgacgctggctcctgctttagaactcaggaga
>IGR2127a
acagggtggtgaagacagaagttccagaagaagccaagagtgctatcttgagtagtgggc
aggtgacccacagaagggcggtgggtgggaagtaggagtgagaggggtctgtgctgaatg
tgccagccttcaggaggctcaggccaggacagggtgtataaacaagaggtgacgctggct
cctgctttagaactcaggagagtatttaggcctaaacacttatgacctacaaaagattaa
aaacttaccaacagtactcaccaatggactaaaacgctaattgtaaacagtgaagtcatt
gaaaaaccagaaaaatattggtgaatacttatctaaggggggaagaattttggataaaag
agcaaacagcattttaaagaaattttagccatattaaaaacaaacaccaagactttaaaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-123-
acagaactcataaacaaaatcaaaagacaagcaaaaacaaggaattatatttacagcaac
actgacagaaaggacatgtccttcatatataaaaaacatatggttgggtgtggctcatgc
ctgtaatcccagcactttgagaggccagcatgggtggatcacttgaggtcaggagtttga
gaccagcttgggcaacatggtgaaaccgtgtctctactaaaatacaaaaatttagctggg
catggaggcttgcgcctgtaatgccagctactcaggaggt
>IGR2128a
ccttcatatataaaaaacatatggttgggtgtggctcatgcctgtaatcccagcactttg
agaggccagcatgggtggatcacttgaggtcaggagtttgagaccagcttgggcaacatg
gtgaaaccgtgtctctactaaaatacaaaaatttagctgggcatggaggcttgcgcctgt
aatgccagctactcaggaggttaaggaaggagaatcgctggaattgaggaggcagagttt
gcaatgagctgagattgcaccactgcactccagccaaggagacagagtgagacttcatat
aaaaaaaaaagcaaaaaacaaaacaacaacaacaacaaaacccaaaaaacacagatgagt
ttgtaatcagtaataaaaatacactctccaaagaaaaacagcactggagctgggcatggt
ggtatgtgcctgtaatcccatctactcagggggccaaggtgggaggattgcttgagccca
ggagttcaaggccagcttgggtaacacagcaagatcccatctctataaaaaataagttag
ccaggtatggtggtgcacacttgtagttctagctactctggaggctgaggtaaaaggatt
gcttgagcccaggagttcgaggctgcagtgagctatgattgtgccactgcgctccagtct
ggttgacaaagcaaggccctgtctcttaaaaaaagaaaga
>IGR2129a
ggtaacacagcaagatcccatctctataaaaaataagttagccaggtatggtggtgcaca
cttgtagttctagctactctggaggctgaggtaaaaggattgcttgagcccaggagttcg
aggctgcagtgagctatgattgtgccactgcgctccagtctggttgacaaagcaaggccc
tgtctcttaaaaaaagaaagaaaaagaaaaacagcattgattatggtattgtgtattata
aacattattttgtattggttagaattttgttcagttacataaaacagaaaacaatagtgg
cttaagcaagatgggattttctttctttctctcactgaaaaaaaaggtctagaaatgatc
agttcagggctggtttggtgacttcaggtgtcaccagggacctacgcttcttctggctca
tcctgcccctattcctaaagtgcagctctcattctcatgtcttgtggtagttgctagagt
gatagtcaccacatcctcatttaagaaagtaggatggagaaaggagggtgaataaagggc
acaccccctcctgttaaggagctggcttcgaagtcccatatgacacccacttgcatccat
tgtccggaacccagccacatgatcacactttgctgcaaaattgccaggggaacgtagttt
tcagctgggtggaaaagggatcagcaaaaaattggttttg
>IGR2130a
tttaagaaagtaggatggagaaaggagggtgaataaagggcacaccccctcctgttaagg
agctggcttcgaagtcccatatgacacccacttgcatccattgtccggaacccagccaca
tgatcacactttgctgcaaaattgccaggggaacgtagttttcagctgggtggaaaaggg
atcagcaaaaaattggttttgttactaagaaagagggaatggatactgtagagcaatgag
cagtttctaacatacatgtgaacaaaattatcaaaagaaatacaaatgtaaaagatttca
gggtcaaccttaccaacagtcaaatataagtaaagcaggtggccttttatggtcttgtct
ggctaaggtattgaagagctggccagacaagtcatgaagacagtcaagaactgactgtct
tcataaggaccgactgtcttcataagaaccttgggacaatgcacatgaacagaacagagt
ttcagggtaaaaatggccctttctccccaactagatggctcaaggacccaagggccactt
cctggctgttcccccaaagtctccctccaactcccaagtgacatcagattctgtaaatgc
tgggaagtagagaaaaattctgtacccagggattctctaactaaactatggctaaaatta
aattttaggtgtttttgaaagttcctttaaaaaagtaata
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-124-
>IGR2131a
tttctccccaactagatggctcaaggacccaagggccacttcctggctgttcccccaaag
tctccctccaactcccaagtgacatcagattctgtaaatgctgggaagtagagaaaaatt
ctgtacccagggattctctaactaaactatggctaaaattaaattttaggtgtttttgaa
agttcctttaaaaaagtaatatcctcatgcaaactgaatcagcagtttcagaacttaaaa
aaaaaaaaagaacctctgtcgtattcttggggtatcacaaattaaacatgaaaaccagcc
actaaaataaggaccagtgtttggatactacatgggggtgatgttaggcaacctcaagtt
atgtcttttggcagattcaggactttatgtgagctcccacagatggtgatgtcaatgcca
ccacccttcagaaggcacagagaaggaaagtgcagaggacacggcaagtgtggattccac
aggcttctgaagttcataggcctattttgaatagttattgtgcctttctcaatccagacc
agcatcagttacctctcacgatttatttgaaagcatttacttctagtgtttgctcttttt
aaatggttgctgattgggaaaaataccagagtaaactgatgtttcatgaagtctggggga
gacgatctttagggcatgggaagcaatatgatataatgac
>IGR2132a
gcctattttgaatagttattgtgcctttctcaatccagaccagcatcagttacctctcac
gatttatttgaaagcatttacttctagtgtttgctctttttaaatggttgctgattggga
aaaataccagagtaaactgatgtttcatgaagtctgggggagacgatctttagggcatgg
gaagcaatatgatataatgacgaaacgtgcccatgctttggaatcagaaacacctggatt
tgagacctagctctgtggtttaccagctgtgtgttctgggacaagttattaaacttctct
ggggctcaggttccttgtcttaagatgggctaatacagtgcttacctcgttgtatcatca
agttgggtaggaaacagatggtgaacttggactgggactgtttacaaaggtgtggggagg
gctcagggaaatcaagatgagacagtgaagcatatgggggctagcaacaatggggagctg
ttaccacttgtaacctgaaggtatgaaggaagggaataaatgggtaaggggacccaaagg
aggcagctattggaagggtgtctggcaggagctgtgggctccagtggaggatgcagttgg
cctaaagcgacctgatagggacccgggggaataacttaaccacttgccctcctcggggaa
ctcctgacctcatcttcctgagtccttccatctcttgcta
>IGR2133a
ggtatgaaggaagggaataaatgggtaaggggacccaaaggaggcagctattggaagggt
gtctggcaggagctgtgggctccagtggaggatgcagttggcctaaagcgacctgatagg
gacccgggggaataacttaaccacttgccctcctcggggaactcctgacctcatcttcct
gagtccttccatctcttgctaatgctccccatggaccaaatctaactagaatccagaggc
aagatagatgagtgatgtggcccattcaggtcagcctcccaacccagagcaggtagagag
gacggagagtggatctgcaggagcaaacagaagattaatcaaaatagagactgtgatgag
gttagcataatgcctggaacatagtaagtccacaagtcctcaacaaatgttaatttattt
tggactttggactctctgtctgcctgttttgcttattgcttacttcctggttttcatcag
ctcatgtatagttgagataacttccaaataatcaagtattgttatctatattggagtgtt
ttgaaggagtaatgagtgtataaaaaagataaccagatactctggggattagagatgaca
gagggaaacagaggaaggggagtaagtaagagaaaaggatggagaaaactgtatgttccc
tatgaggctggaatgaacgcaagattatcttactttaaaa
>IGR2134a
acttccaaataatcaagtattgttatctatattggagtgttttgaaggagtaatgagtgt
ataaaaaagataaccagatactctggggattagagatgacagagggaaacagaggaaggg
gagtaagtaagagaaaaggatggagaaaactgtatgttccctatgaggctggaatgaacg
caagattatcttactttaaaatcaaatcatgcacttattgggatgtgataacagtgcgtt
tgcaattttacagcccagtgagacttgccagaaagggattttgcaaggaaggtcttcctg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-125
ccctaaaggaaaacctagtgcttacttccagattaataagtcttaacccatcatgcctgc
tcccccaaaaccaagtagtcaaatgtgttaacctggatgtttaaatacctgcatgttcct
gcctgggtgcctgggtcaggtgaatgttctattctgatttgggaaatggctagagtgtgt
tggtcgtcgcctgggatagctcccaggtaggaagggagccccagagagtggtctgaacag
tgactcataaactcagtgtcctttcctccagcctttaccagctgctgacttggcccctta
ggaatctgtcttcattccgcaagctattctccagtgtctggttcaggctctagagcagag
cattccaggctttctgtgattcctggccacctgttccatc
>IGR2135a
ctcccaggtaggaagggagccccagagagtggtctgaacagtgactcataaactcagtgt
cctttcctccagcctttaccagctgctgacttggccccttaggaatctgtcttcattccg
caagctattctccagtgtctggttcaggctctagagcagagcattccaggctttctgtga
ttcctggccacctgttccatctccaagaccctccagcatccttctctcatttgcttaccc
taccctccaggcctttgcacaggccactctctgtgcctgggacatacattctccttctgg
ctaaccttccgcagcctccaggacctctcaggtgtcctctcctctgggagccctgctgga
ctgcccacggggagttgggaagcccttctgtatgctcctgttagccctctttgattctct
cactcacagcacttccacactgtcttggtttcctggctcatctctcccaacacactggac
accccttgagaagagacttgacatattcatcttgattttaatgccatccggcaaaattcc
tggcactcagagggcatgcaataaaactttactgaatgaaggtttagcgcgtaattcaga
aaataagcaagaaagtgtcacaaacaccaaagcaagttaaccaagctatatgttctagaa
cattcttcctctcctcctgtcactctggctctcctgcgcc
>IGR2136a
gacatattcatcttgattttaatgccatccggcaaaattcctggcactcagagggcatgc
aataaaactttactgaatgaaggtttagcgcgtaattcagaaaataagcaagaaagtgtc
acaaacaccaaagcaagttaaccaagctatatgttctagaacattcttcctctcctcctg
tcactctggctctcctgcgcctacagcagacaggacagagtctgctctttcacctgctct
tttctagtcttttctttcaggtatcccctgaaatgccacttcctcagaggctatccttga
ctacccaatccaaagcagtcactcagtcacttgattacacttcagtctattttaatttgt
tagagagcacttactgctagcaccaatgttttatttctgtgttttctttctatctccacc
attatgctgtagctccatttgagcagggaccttgtctgttcactactgtatgcccagcat
ctagtacagtgtgtggcagagagtcaagtgttcattaaatacttgttaaatgaatgcatg
ccactgttactgcatgctgagttaatttgatgtatggcttctatcactgctatcagatta
ggtgctctagagaaactcagaaagggctgagtctccttatgacattgcagggtgggaggg
ggacctcagttcccttcctaggcctaagtgggatatgctg
>IGR2137a
agagtcaagtgttcattaaatacttgttaaatgaatgcatgccactgttactgcatgctg
agttaatttgatgtatggcttctatcactgctatcagattaggtgctctagagaaactca
gaaagggctgagtctccttatgacattgcagggtgggagggggacctcagttcccttcct
aggcctaagtgggatatgctgcctgcttgcagcttccttgtggcctggacttccccatgg
aggccagatgctgagcaaccccagcccatgtgtctgaaggctctgaataccgaaatgttc
ctctagctttctgtgagagcagttggagctgcccattgcctacactgatagaggaatgtg
cccagggctcctggctggcctggcacccagcaggaggcaggcacagtggccagcacggtg
aggacacatcacacttcttctttttcccatatccctatgctgagagtgcatgcagctgcc
tggctgggagcagaaactggcctcactttctggggcctgctgggcagacaatgcagctct
ctagctgtgccacagaacagggcaaatctttactagctgtggactcactccctgcccctc
ccattcctgcagaaattgctctaccagctcagcagagggccaggtctggaatctctcacc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-126
tgtccctggcccttcctttaagccctctggtttactggaa
>IGR2138a
gcctcactttctggggcctgctgggcagacaatgcagctctctagctgtgccacagaaca
gggcaaatctttactagctgtggactcactccctgcccctcccattcctgcagaaattgc
tctaccagctcagcagagggccaggtctggaatctctcacctgtccctggcccttccttt
aagccctctggtttactggaaatcataaactgtgagacacagcctttatcacaccctgaa
cagttcactcttaatatttaatgctggaggctaaaacaaccagggacactggaggcctcc
tgcttactctcagtgactgatgtttgcacctggtaattgaggtcaggttgcttctcttaa
gtcacatgatttgcgtcaaagcaggaaggtgtcggggccacttgttgcaaagagaccagg
aggcgatcccagcaacgctgcaaaccagctttggcagcaaaggctgtgctttcatgggag
ccagccctaggagtgtggagctgggctggcagctggtaaatgaccctctcggggcctgaa
taaaccctagcttttcactcacagcaaactcaggatgccttcctccctctaaaagacctg
ctgaattgagtcactttcaatcctttctggagtaggatggggcattagttaattaacaaa
ttaattaagcatgctaaatagtcacccagaagatactggt
>IGR2139a
gctgggctggcagctggtaaatgaccctctcggggcctgaataaaccctagcttttcact
cacagcaaactcaggatgccttcctccctctaaaagacctgctgaattgagtcactttca
atcctttctggagtaggatggggcattagttaattaacaaattaattaagcatgctaaat
agtcacccagaagatactggtcacttaagggtctccaaatcacagtataggtcccaccct
acccagacacctaatcttgtttcagggtttgcttgacctcaggcatttatctcctggttg
tcatggaatctgctcagataaacagcagcacaccaacctggcccctctgccagcctcaga
tccttctaaggcagtggagctccctggtggccaccagccacccgggctccaggcagccca
acacacactcccatgctgaggtctctcgcatgacctctctaggcacacagtaggtgctca
gtaaatgctgtggcatgaaggaccctcctggagtgtctgagttctcaggcttcaaggccc
ctagataagcagatttctctcccctatcaccatagtcaccccagggactgcagggcaggc
cgaaatcagccagtgactcagctccttgggcaattcagctggcccacagaccacttcctc
tgctccccagcgccggatggatgcagatctgtgagtaagg
>IGR2140a
ggaccctcctggagtgtctgagttctcaggcttcaaggcccctagataagcagatttctc
tcccctatcaccatagtcaccccagggactgcagggcaggccgaaatcagccagtgactc
agctccttgggcaattcagctggcccacagaccacttcctctgctccccagcgccggatg
gatgcagatctgtgagtaaggagccagctgcaggcaagcagctcgagggcaggtgggcat
gatgtctggctaccactcgcactggacgccacacacacagccagggtggcagaaggcccc
acctgccatgtgccagtgggacaccaccctcatggtctgcgtttccaggtttccaactaa
ggactgagcacactctcaacatggacctcctaactgctctcgaggatggacagctggcct
caagggaacactgcaaagtggctctaggaagaagccactgtccctccagaccataaaaat
ggctaccaagggcagagccagcagctttcgctgtaaagtttctcaagaaaatcacagata
ttcccctctgtgatgttcagctcagcctggaaaggaggtaagaaagaccagactacctga
tctctcaaggtcaccaaattcaaccactgtcctgtttaaaagcgggtagtacagaggcca
gtgtgggctctggaatgagacatgtgaagcccgggtctgc
>IGR2141a
agcagctttcgctgtaaagtttctcaagaaaatcacagatattcccctctgtgatgttca
gctcagcctggaaaggaggtaagaaagaccagactacctgatctctcaaggtcaccaaat
tcaaccactgtcctgtttaaaagcgggtagtacagaggccagtgtgggctctggaatgag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-127
acatgtgaagcccgggtctgctgggtctgctgcacggtagcagtgtagtcttaggcatta
ttgaaactctgtttctaaatctggttatgtgaatgaaaggggctaatttatgtaacactt
ttagtatactaagccctcaatatagtttagctacttaactattgtcttctttgaaggacg
ctgaactaaacagaagagaaacagggaaataaacagcatggcaacctacatcaacagaaa
cttaattattcaccctggataactgagtgtgtgagtgtgactgcaaataacaatatagca
aagagaagtttgagatctttggctcagtcattctagaatcctgagtcacagcaaatgcac
agcctccatgaggctgagccacacatgaaagctgcttccacccacagactggtagaggcc
actgacatgcttaacgatgatgatgatgataaaaatagctaccacgggctaccacgtgca
cacacatgttaagcagttcaaacaggttattttgtttaat
>IGR2142a
tggctcagtcattctagaatcctgagtcacagcaaatgcacagcctccatgaggctgagc
cacacatgaaagctgcttccacccacagactggtagaggccactgacatgcttaacgatg
atgatgatgataaaaatagctaccacgggctaccacgtgcacacacatgttaagcagttc
aaacaggttattttgtttaattcataccacaaatctttgaggtaagtattcttgttcccg
ttttatagaggtagaaactgagagttgaagaggctgaataatttctcaagcacactccca
actcgaccacccacaagcaaaaaggcagagctgggattcaaacacaggtatgactgtgtg
tggacatctcccctgtgctatgctccctgaaggaaaattctaagtggtgttgtttctggg
agaaatctacctgtgtggtctttaaacctactctgacaggagcaagggccaccactctgt
atctaagaccactgggaacagtcttcaggcaacaaggtgaccagggcagctgcagagggt
atctatgcccctgccccctagcgcaaaagtctgtttctctttccaaatggcccgctggga
gcaactatttagggagaccatacctcctcccacactcagttcccaggcctgagccacaga
gtcctgccacaggagggaggacctgcctgtcctgctccct
>IGR2143 a
agtcttcaggcaacaaggtgaccagggcagctgcagagggtatctatgcccctgccccct
agcgcaaaagtctgtttctctttccaaatggcccgctgggagcaactatttagggagacc
atacctcctcccacactcagttcccaggcctgagccacagagtcctgccacaggagggag
gacctgcctgtcctgctccctccccactccaggttcctggaggcctctgtgatgattccc
caggaaggactacaggatctggcaggcagcaggtggcggtgggaggaggagagtcctggg
agcacagcactcctaaccccctctgcctctcacagaacaaagagggagtcatgccatgtc
ccctgctcccacaaatgccccacccagaggggctaatgcctaggattgagggtcttgtgt
gctgaggaagtcctgtcccccaatcccctacaaaagccagaaccagctactaaggggtta
gacacagacagaactgtctatattaacatttcctcctaaaaaacaacaggaatcctgggg
aaagaccactggcctgggactccatgagccctggcttctatctctggctttatcaggtga
ccacaggcaagtcacctagcctccatggtctaggccctcctgcctgttgggtgggaatca
ttacatatcacaatcattacagctgaccttcagggaggct
>IGR2144a
atattaacatttcctcctaaaaaacaacaggaatcctggggaaagaccactggcctggga
ctccatgagccctggcttctatctctggctttatcaggtgaccacaggcaagtcacctag
cctccatggtctaggccctcctgcctgttgggtgggaatcattacatatcacaatcatta
cagctgaccttcagggaggctgtactctgggtcaggaattgtgttgggtgcattatcata
tttattctcacagcaccctttgcagtagctactattttcatacccattctcagatgagga
aactgtggaacaggctggttaggggacatgcccaaagtgacaaacttagcaaaggtggac
ctggcactcagtaccacatctgtttttccatgctcttaaccactgtaacatacagagccc
ttttacagagatcaaggacagaggtaaaagtgttttgaaagcaaaaaaaaaaaagcgggg
aggatgcataaaataaacataaatcaccccctgccccgcccagacataattcagggaaga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-128-
gtcctaacccccaagaaccttctgtggaacttattcgcaacatcagagacctccaacata
gaaatgaccctcaataagtcatttctttcttcctctttcccttcaggcaggaataatata
actaactgaattatacaggtgagaccacgaaggtcaagca
>IGR2145 a
taaatcaccccctgccccgcccagacataattcagggaagagtcctaacccccaagaacc
ttctgtggaacttattcgcaacatcagagacctccaacatagaaatgaccctcaataagt
catttctttcttcctctttcccttcaggcaggaataatataactaactgaattatacagg
tgagaccacgaaggtcaagcaagggtgaccagcttaggcccctggctggcaggtaaggag
gagactgaccccagcctcctggctcctaggggaggaaacagtgatgacaaaggccccttt
gcatggccaaggtggagccctttctaccaaagtttaaacgttttagtataatatccaagt
gcatcttttccaaccttaaaaacatatttaatttccttataaagctggttggcactctcc
tcctcctccaaagctctgtattaggcagggttcatagttgtagacaacagaatgaacagt
ggttagttcagccagaaaagggatgatataggaggatactgggttgatcaaaggctctct
gggagggctgcagatttagagccagtcagccaggaacgatgcctgaaacataccttagag
ctggagaaagaacaaaaccctacctttcttcaatagctggcaaggtggcaaggtctggcc
ccatgcagcctgggctcttcccactctcctctctccctaa
>IGR2146a
gggatgatataggaggatactgggttgatcaaaggctctctgggagggctgcagatttag
agccagtcagccaggaacgatgcctgaaacataccttagagctggagaaagaacaaaacc
ctacctttcttcaatagctggcaaggtggcaaggtctggccccatgcagcctgggctctt
cccactctcctctctccctaatgcgttgccctactcgctgcttcccaggcaatcccacct
caggtctatgaacttgccattccctctgcctgcaacctagacattcacattgctagctcc
ctggctagctcaaatgccaggtttctgcacaaatgctcctccttagagaggccttcctgg
acctctaggtctctggccctagtactctatcccctctccctgctttcctcttctacttca
ctgctccttaacattgtgttatacattgtctgtctccccaactggaatgtaagtggcacc
agggcagggacttgggttgttttgttccttgctgtaagcccagggcccagggccagacct
ggaacaattaggtgctaagttatttgctgaatattctatgaaggaatgacaaaggaatgc
ataaagaacttcaaagttcaactcctcgaacttcaaacttcaaatccccaactcctcctg
cctatgctggacgattagggcagtaacaggagtcaacttg
>IGR2147a
ttttgttccttgctgtaagcccagggcccagggccagacctggaacaattaggtgctaag
ttatttgctgaatattctatgaaggaatgacaaaggaatgcataaagaacttcaaagttc
aactcctcgaacttcaaacttcaaatccccaactcctcctgcctatgctggacgattagg
gcagtaacaggagtcaacttgtgctgtgctgtcaccttgcctggatccgcatcagccctg
cagctcccactttggaggagacttgcccagggacctacagctctgaagcttctctgacag
cctctgcagctcttggaacttatctgggctgctgctgtgcagaccatggatgcgtagctg
agttcctgcccctgatttcctagagtctcagaaagacagggaagtgacttacccaaagtc
ccctttcaccctataaacagttcagcccagggagtgaggctgacacgcaaatgcagctat
gtatagactcagagtcatccaaggtcagggctgggtggagccttggtcacatgcaggcca
acctgtgtctggagataatgcaagccagtgcaggggttagcgtgtacatggactctggag
tctggcagatctaagccccacccaccaacctgtgaccttggagaattatttgaaaagaca
ttatttgaaaagcagatgtaaaatggaaataaaagttcct
>IGR2148a
caaggtcagggctgggtggagccttggtcacatgcaggccaacctgtgtctggagataat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-129
gcaagccagtgcaggggttagcgtgtacatggactctggagtctggcagatctaagcccc
acccaccaacctgtgaccttggagaattatttgaaaagacattatttgaaaagcagatgt
aaaatggaaataaaagttcctatttaaaacagtcagttgtcccccattcagaagcctatt
acagttgtccctcagcatcttcgaggaattggttccaggacagctcctcagataccaaaa
gccacgatgctcaaattccttataaaaagtgacgtagggctgggtacaatggctcgtgcc
tgtaatcccagcactttgggagaccgaggtgggcagctcacttgaggtcaggagttcaag
accagcctcgccaacatggtgaaaccccgtctcctctaaaaatacaaaaaataggcgggc
ttggtggcatgcacttgtagtcccagccactcgggaggctgaggcatgagaattgcatgg
atccgggaggcggaggttgcaataagccaagatcgcaccactgcactccagcctgggtga
cagagtgagacttcatctcaaaaacaaaaaacaaacaaacaaaaaatgtgtagcacagtc
agccctccgtatccacaggtccacacacagaacctgctgg
>IGR2149a
gtcccagccactcgggaggctgaggcatgagaattgcatggatccgggaggcggaggttg
caataagccaagatcgcaccactgcactccagcctgggtgacagagtgagacttcatctc
aaaaacaaaaaacaaacaaacaaaaaatgtgtagcacagtcagccctccgtatccacagg
tccacacacagaacctgctggtatggagggccaaccgtgcttcctattcttttttttttt
tctttgagacagagtctcactctgtcacccaggctggagtgcagtggcacaatcttggct
cactgcaagctccacctcccaggttcacgccattctcctgcctcagcctcctgagtagct
gggactacaggcacacgccaccatgcctggctaattttttgtatttttagtagagaaggg
gtttcaccatgttagccacgatggtctccatctcctgacctcgtgatccacccgcctcgg
cctcccaaagtgctgggattacaggcgtgagccaccgcgcccggccacttcctattcctt
atggtatcaaattcaaactccttggcttgatagtcaaactctcaccacgactgaaatctg
gttaaccaacctgtccaatacaatctctctgcactcctccaaataatgttcaagttggac
ctaagtgctccctagtccttctcacacctgtgtgcctgga
>IGR2150a
tacaggcgtgagccaccgcgcccggccacttcctattccttatggtatcaaattcaaact
ccttggcttgatagtcaaactctcaccacgactgaaatctggttaaccaacctgtccaat
acaatctctctgcactcctccaaataatgttcaagttggacctaagtgctccctagtcct
tctcacacctgtgtgcctggaaacaccacccaccttcttttctctcatctgaatttacta
gagccccagaggcaggtctcatagtcttccctgacttgggtttttttggcactgactact
gggcattcatgatgggacctgcccctggggctctagtatttggtgttacagggaggaaca
cagttttgattccccaaacagaacaaaggatccttgagggcaactgtctgttgtcatttc
atgtctcccccaaccaggcattaaaacacgcatagaaattcctgctgacgggctcttgtg
aagttacaagttacaatttggtgaaaatgcccccaagtatttcctctatttcccaaggaa
aggaaaagaaagatatagaaattaaattaaagacaaacttaaatcattcccatttctgca
tgcttggtctgtgtgggaaaaaaaaatcatttcatctctgtctgcaacgcagacttgaca
agttgagaaactccctaaaaacaaagcatacaaaaaaaaa
>IGR2151a
ggtgaaaatgcccccaagtatttcctctatttcccaaggaaaggaaaagaaagatataga
aattaaattaaagacaaacttaaatcattcccatttctgcatgcttggtctgtgtgggaa
aaaaaaatcatttcatctctgtctgcaacgcagacttgacaagttgagaaactccctaaa
aacaaagcatacaaaaaaaaaatcataccaattagtctcacttaaaggtttcaggaagga
aaacacagttaaactgaaaacggttaactggtgtttaaaaaaaagaaaccagcccggaaa
tgtttttaggactgcgtctatcgaagtcccttagggactgatttgtccttcaatatattc
atagcacctgctttcaccaaaacccagcagcccaacgctagagctttgtgagtgagatgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-130
agagtggaactggacatggagctacacagctctgaatcatgttccccaacagcaagcaac
agccacatgaaggattcctggcagtgccctctagccactacagtgggccatgggaagccg
tacaaacagcaaatggcatcctgcaaccccagcttctccttctgccgcattcctctctct
gtccatgcctctgcttccccattggcccactggccaaatacactcagaaaaaagtccatg
cacaagcctccacccaaattaattccacattctttcaaga
>IGR2152a
ggcagtgccctctagccactacagtgggccatgggaagccgtacaaacagcaaatggcat
cctgcaaccccagcttctccttctgccgcattcctctctctgtccatgcctctgcttccc
cattggcccactggccaaatacactcagaaaaaagtccatgcacaagcctccacccaaat
taattccacattctttcaagagaggccttgaaaggtactgaaattcagggaagctcttca
ctagacccctcactggaatgccaagaagtgatgtagtggcccttgacataagggcttatt
cccatttatgaaactgaaattattttattctaagcacaaagctaacaaatgtgatcaaaa
cagaaaataaacaatcctcattcaagtgctcagaatgcagcacaaataggatcttgggat
aaataagatagagctgtgaaattaataggggtgagaagaggggagggtcagcgggagaag
tccaccaaggggctgaaaggcctgtgcaggcagacggaaaccctgggttcttaggggcca
ggcatgacagtgcagaatagtccaccctgggagtgactggaagaaggactgcagggtccc
cgtgaagaacacctcacactcccagcttgccacacacttgttgaactattctgggtggat
acctcctacctggatggcaaaggagacaggcccaagatgc .
>IGR215 3 a
gcctgtgcaggcagacggaaaccctgggttcttaggggccaggcatgacagtgcagaata
gtccaccctgggagtgactggaagaaggactgcagggtccccgtgaagaacacctcacac
tcccagcttgccacacacttgttgaactattctgggtggatacctcctacctggatggca
aaggagacaggcccaagatgcagaagggaagggaagtcacacttacaatgcagaggatgc
gcccttgtccctcatactctctgaaacattgcaggaataattctggtttcactgctattg
tttgttgtttttgtaaataaaccgcaaaaatcaacaaatggcctcaaaattgaacacatg
tgatttacaccaattcatatatcaaaacacaaataatgcagaacaaattagagaaaaact
ccagtcaggctctccactcacccatggctggtggctggcattcaactctccagcagccag
ggagtccattttcttgtttctctgctggccatcctcaggacttgcggcggggagtggggg
gcccagggtgtgctgccacctgcaggccaaacaaggaaaaaacataagcaacggccacaa
tcatccgcctgaagcccctcctatatcctcaggccgctggaagacctggatgcccgtcgt
gggacaagagccagaagcactcacccagtgccaacacctg
>IGR2154a
ctctgctggccatcctcaggacttgcggcggggagtggggggcccagggtgtgctgccac
ctgcaggccaaacaaggaaaaaacataagcaacggccacaatcatccgcctgaagcccct
cctatatcctcaggccgctggaagacctggatgcccgtcgtgggacaagagccagaagca
ctcacccagtgccaacacctgctgggccacaaacagtttctgcttgggatcccaacacag
gcagcagagtcagcaaaaactctaagatatcaagaagtcaagcatttcttaacaacagca
gcaaactcttacacagggctgtggttaccagacactgctctaaataacttacacttgttt
acttatttcatcctcacaacaacgggtaaatattttaggtctctgccaatttgcctgatt
actgaattaggttgaatcattaaaatgaataacttgataatacccaatttcaaagagggg
tcacatatgaaaactctatgagagattctcagcatcttgcagacattcattccctaaata
ttcattgagtgtttgttatggacgagacactgttctaggacctgggaagagaggagcgaa
cacacaagacaaagtccctgttctcacgaagcttctgttccagtgcggggaggcaacagt
agaaaaggagacaaatgccatgcagaagaaaaagcaggga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-131
>IGR2155a
gagagattctcagcatcttgcagacattcattccctaaatattcattgagtgtttgttat
ggacgagacactgttctaggacctgggaagagaggagcgaacacacaagacaaagtccct
gttctcacgaagcttctgttccagtgcggggaggcaacagtagaaaaggagacaaatgcc
atgcagaagaaaaagcagggaaaaagagatagagcacaatgacaatgctgttaataccca
ttcatttattcacttatttccaaggacttactaaccatgtcatttcttgcccacagctgc
atgccaggcactatgccagataaaattgtgggtaagaaatagacatggtctctgcctgta
tggagtacttacataagaggaacatctattattagtcaaataatcacctaaataaatgca
aagatgttaatctgtgataggtgtgatagcagaattgcatgtagtccttgtgagagcatc
tcaaggaggcctgaccttgtctaaggggaggcctgaaatggagtgtggggaggagcaatg
tgttagtccattttgcattgctataaaggaatatctgaggctgggtaatttataaagaaa
agaggtttaaggcggggtgcagtggctcacacctgtaatcccagtactttgggaggctga
ggcaggtggatcatctgaggtcaggagttcgggaccaacc
>IGR2156a
tctaaggggaggcctgaaatggagtgtggggaggagcaatgtgttagtccattttgcatt
gctataaaggaatatctgaggctgggtaatttataaagaaaagaggtttaaggcggggtg
cagtggctcacacctgtaatcccagtactttgggaggctgaggcaggtggatcatctgag
gtcaggagttcgggaccaacctggccaacatggtgaaaccctgtcgctactaaaaacaca
aaaattagctgggtgtggtggtgcacgcctgtaatcccagctacttgggaggctgaggca
gaagaattgcttgaactggagaggctgaggttgcagtgagccaagatcgtgccaccgcac
tccagcctgggtgacagagcgagaatccgtctcaaaaaaagaaaaagaaaagaaaagagg
tttggctcacagttctgtagactgtacaagtgtggcaccagcatctgcttggcttctggt
caggcctcaggatgctcacaatcatggtgaaaggtaaagggggagctggcatgtcacatg
gcacaagaaggagcaagaaaggggaggaggtgccaagcctcctttaaacaaccagctctc
gcctgaacagagtaagaactcactcattacctcggggagggcaccaaaccattcatgagg
gatccagccccatgacccaaacacctcccaccaggcccca
>IGR2157a
aatcatggtgaaaggtaaagggggagctggcatgtcacatggcacaagaaggagcaagaa
aggggaggaggtgccaagcctcctttaaacaaccagctctcgcctgaacagagtaagaac
tcactcattacctcggggagggcaccaaaccattcatgagggatccagccccatgaccca
aacacctcccaccaggccccacctccaatgctggcgatcacatttcaacatgagatttgg
aagagacatgcatccaaaccatatcaagcagtgtccctgtcaaaagcacaccctgtgcac
aggctggatcatgggtagttggcagggacaggaggcagggtgaagctggagaagcagtgt
aggtgacccttgcatgacactcccagccacaagaggagttcgagccttaaccctggagaa
ctggagcaccacacaagggtcttaggcagaggattaatgcatttagatgtgtacttttaa
aagattatctatgtaggctgagtaatggccctgccaaagatgtctatgtgtgaatccctg
gaggttgtgtgtatgttcccctatatggcataagggacattgcaaatgtgatcgagttaa
gggtcctgagaaccggagattatccaggtgggcccaacataatcacaagtgtccttataa
gagggaggcagggggagatctgacttcagatgaggagcct
>IGR2158a
gagtaatggccctgccaaagatgtctatgtgtgaatccctggaggttgtgtgtatgttcc
cctatatggcataagggacattgcaaatgtgatcgagttaagggtcctgagaaccggaga
ttatccaggtgggcccaacataatcacaagtgtccttataagagggaggcagggggagat
ctgacttcagatgaggagcctcagaatgatgtggcacgagaaagacttggcttcgaagag
gaggaaggggccctgagccagggaatgcagtggcctctagaagctggaaaaagcaacaaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-132-
acgattctcctctagagcctccagaaggaacgcagccctgccaaagccttaatttcagga
cttctaaaagagtaaatttgtgttgttttaaggcactgattttgtggtaatttgttacag
cagcaataggagaataggacatactagctcctgtaaaaaaccagactggacgtaagggcg
aggcgaggcagggaccagctagaggtcactgctgtggtccaggcaagaggtgtgagagct
tgcaccacagtggtggccgtggggatggagaggagtggtgcagttgaaggaccccagcag
gggaagagctgaccagtcaaaggtctcgctgcaatctggcagatgttactggaatgccac
aacaggcctctttcaggctcaggccctggctggctcaccc
>IGR2159a
tagaggtcactgctgtggtccaggcaagaggtgtgagagcttgcaccacagtggtggccg
tggggatggagaggagtggtgcagttgaaggaccccagcaggggaagagctgaccagtca
aaggtctcgctgcaatctggcagatgttactggaatgccacaacaggcctctttcaggct
caggccctggctggctcaccctggctacagcccagcagctttacagaaggaggaagctca
caccagggctgtagaccactcccaggcagatgcaccatttactcacttaacctgccaacc
ccattcccacaaaaaagttcaagagtctccaggaacaagccctaagaaagaacacgtggg
gaatttttactaggcaaaaggtagcaattatttctgccaagcattaagccttgcagcgaa
ctttttttttttttccgtgaacagagattttgtaattctggaagagaggtgtccagattt
aaatatacacatctccaacacaggtgatacagaaccatgattaaatctaacatctaaaaa
cttcatggtcagcagaaaatgcagaaattaaagaaagactaaacaagaaactaggagact
cagcgtctactctattcttgcttaataatccagacctacttaaaaaatgggatcctaatt
tggtcctgtttaatggagctgtcaagaagaaaaagcaata
>IGR2160a
acaggtgatacagaaccatgattaaatctaacatctaaaaacttcatggtcagcagaaaa
tgcagaaattaaagaaagactaaacaagaaactaggagactcagcgtctactctattctt
gcttaataatccagacctacttaaaaaatgggatcctaatttggtcctgtttaatggagc
tgtcaagaagaaaaagcaataaaaattattcgagagaattttagaaacattctcccattc
tactccaaaaatataaatatgcacactccaaaaccaagtaccttggactgtactgagaga
tgacaatgacgtcttaaccgtactatttccccatgatgttgcagcaggccacagggacct
aactgaattgtaagaacatgaaaggacccaggaatgcctgcagatgacaaaataccaggt
agtcctgtcagtgtaggagcatgttaatttaaaaatagatatatttttctggtgacaaaa
gtgacatgtctattactggaaaacacaaacaactcctgtagtccaatgatccagagataa
cccatttggaaatattttcttccagtcttttttccccattgatttcggcacaggcgcgcg
cacacacacacacacacacacacacacacacacactcatacttcatttttaacaaaatta
caatactgtatatacttttataaccagttttatataacag
>IGR2161 a
aaaacacaaacaactcctgtagtccaatgatccagagataacccatttggaaatattttc
ttccagtcttttttccccattgatttcggcacaggcgcgcgcacacacacacacacacac
acacacacacacacactcatacttcatttttaacaaaattacaatactgtatatactttt
ataaccagttttatataacagtatataatcctccatgtattaaatacagtttttcataat
gctagtattccatcatatgaaagtaggaaaatcacttaaccaatccctaattgctgaaca
actgagtagtttctaactttatggtaacataagtcattgggaggaacctcctcatctacg
ggaatatccctagatataaatctatgtctatagctctgattatttccttagggtcctatt
tcctacatccatgcattgccattactattttgctataattaattaccatctgtaatgtac
ttaacatttctctttacatcaactcatttctgtccttaaacaaatgtattttaaaagcaa
acctgactcggtgtagtggctcacacctgtaatcctagcactttgggaaaacaaggcagg
cggattgcctgagctcaagagttcaagaccagcctgggcaacatggcgaaaccccgtctg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-133
tactaaaaatacaaaaaatcagccgggtgtggtggtgcgt
>IGR2162a
caactcatttctgtccttaaacaaatgtattttaaaagcaaacctgactcggtgtagtgg
ctcacacctgtaatcctagcactttgggaaaacaaggcaggcggattgcctgagctcaag
agttcaagaccagcctgggcaacatggcgaaaccccgtctgtactaaaaatacaaaaaat
cagccgggtgtggtggtgcgtgcctgtagtcccagctactcaagaggctgaggcacaaga
atcgcttgaacctatgaagcagaagttgcagtgagccaagatcatgccactgcactctag
cctggacaacaggacaagactctgtctcaaaaaacaaacaaacaaacaaacaaaccttat
ttaagtggaaaaccaacatcatatgccataaatgaaggcaatcataataggttttattgg
aataaaaaaacactgtggttaaaatatagtcaaaatactgctacccctttgcccattctt
ttatataaaatgggagattagagaggcttagagaggtgttaaaggtatgctagcaccaag
ctaaagtttttcaccttccgttgatcagaagactgaaaaggaattgagcatgggaataac
tttctcactgtgagtcagtgttagacaatgtggcaaatgtgtcccaactagaattaccct
gcgccacctgaaataacctcatatgaaaacatgccttagg
>IGR2163 a
agagaggcttagagaggtgttaaaggtatgctagcaccaagctaaagtttttcaccttcc
gttgatcagaagactgaaaaggaattgagcatgggaataactttctcactgtgagtcagt
gttagacaatgtggcaaatgtgtcccaactagaattaccctgcgccacctgaaataacct
catatgaaaacatgccttaggacatattcctggaagtagaactgggataaaaggcatgga
cactttaagcagcttctgataaccacagcccaaacaccatccaagttagttttaccacag
ttttactatgactgtgtccattttacttcacgttcacaaatattaagtactataaacaaa
atattaaaatagttaaaacgtttcagctttttgatgtaaaatatccagcagctgaatctt
caaaggctattttcatgctcttctagctagtccctgaccctagggcagggctattttatg
aacctttaattagtggtaagcttacaacaaactgatactgcacttggtttcaccaagctg
aagtaaactctgtaaaagatgaggaagtgactttagcatttgcaaatatttcagaatgcc
tttgtgccagcaaaggtcaaacaacgatcagaattgcatggattccaaagtatacttttg
ggaaataagagactcagagaagcattactcaagatacaat
>IGR2164a
gcttacaacaaactgatactgcacttggtttcaccaagctgaagtaaactctgtaaaaga
tgaggaagtgactttagcatttgcaaatatttcagaatgcctttgtgccagcaaaggtca
aacaacgatcagaattgcatggattccaaagtatacttttgggaaataagagactcagag
aagcattactcaagatacaattcactatgaattttcagcaattcaatgaaaagtctaaaa
gaaatacatgtttaaactttcctatcctggtataatatgcaattgcacaaataggttaga
ttgtagattaatgcaattgttaatatttctaacatagaaaaaggaaattgtattttgaag
caagaagaattaataacaattggaattgttcaggttattttaataattcccaggcagata
cctatgtgtatatgtgcctgtggggaaaaggtaaggaaaaagagacgtgagaaaacatac
ttatgtaattccagcactttgggaggctgaggcgggtggatcactaggtcaagagattga
gaccatcctggccaacatggtgaaaccccgtctctgctaaaaatacaaaaattagctggg
catggtgggacctgtagtcccagctactcgggaggctgagacaggtgaagtgcttgagcc
cgggaggtggaggttgcagagagctgagattgtaccactg
>IGR2165 a
tgggaggctgaggcgggtggatcactaggtcaagagattgagaccatcctggccaacatg
gtgaaaccccgtctctgctaaaaatacaaaaattagctgggcatggtgggacctgtagtc
ccagctactcgggaggctgagacaggtgaagtgcttgagcccgggaggtggaggttgcag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-134
agagctgagattgtaccactgcactccagcctgggtgacagagcgagactccatctcaaa
aacaaaaacaaaaacaaaaaataaaaaaaaagatttattatgtttggaaggaggttatag
gttctgattaatttttgccagagacaaaaatacaagtttatctaagcttaagaactaaat
gatggcctattgtaagatatagaacttccaactcactgaataaaaagaaggaaagaagaa
acaggggacaaatacactttgatgaatccatagagtcacaaggaaaaaaaaaacacacat
gataaatacatggcaaaacaagatggcaaaaataagaccacatttatcagtgatcaaaat
aaatatgaatgaattaaattccattgttaaaagaccaagactttcaccctaaatgcccat
aaatggaaaatggataaattatggtatgtattccattttaatggatgtgtatgtgtgtgt
atgtatgtgtatgtgtgtgtatacaccacagaaagaggcc
>IGR2166a
aagatggcaaaaataagaccacatttatcagtgatcaaaataaatatgaatgaattaaat
tccattgttaaaagaccaagactttcaccctaaatgcccataaatggaaaatggataaat
tatggtatgtattccattttaatggatgtgtatgtgtgtgtatgtatgtgtatgtgtgtg
tatacaccacagaaagaggcccatgagtttcagtttagaaagatgtagaaatatatttgt
ataagcataggaaagggtccagaaaaacacaccaatatgatatctgtggttgcctataaa
gagcagtttacctatgagtttcagtttagaaagttgtagaaaaatatttgtataagcata
ggaaagggtccagaaaaacacaccaatatgatatctgtggttgcctatggaggctgaagt
ggactttcctgtctcactttacaaatgtctatactgtttgaatttattacaaaagcatat
gactaaagaaacatgaaaaaatggaataataaacataagggcagaatcagcaaaatagag
gacatagaggaccaaaaaaaaggtggttaacaaaacttgaagtatttatttgaaagtaga
caaacctctagtgagactgatcaagaataactgacagaagattttttaaaaatgagatta
cagaaaaaggaagaaatgacaaataaaacagacattttaa
>IGR2167a
aatggaataataaacataagggcagaatcagcaaaatagaggacatagaggaccaaaaaa
aaggtggttaacaaaacttgaagtatttatttgaaagtagacaaacctctagtgagactg
atcaagaataactgacagaagattttttaaaaatgagattacagaaaaaggaagaaatga
caaataaaacagacattttaaaacttataaaggaataatataaacacatgataatacatt
tgaaaatacagatgaaatgaataatttctagacaataaaaattgccaaatttggcacaaa
aatgtgaataaccacttaagagactcaaataattttgaaacctcttccccatagagtttc
agacccagaagattttacaagtgcctcctactaacttccaaggagcagaaaatctctatc
ttaatggagttgctttagaaaatagaaaaaaagagaaaacattgcccaatttgttacttg
attttgaaatgttaaatatggactgtacaaataaagaaaaatacaggatagtttcactta
taaacatagatgttaaactcctaaataaaatattatctaatcaaatacgaaagtgtatta
caaatacatcatgataaagtaattcaccacattagtcgattgtggaagaggttactagtg
ctcaccagtctctcgttcttttcctcctgggaacaccacc
>IGR2168a
ggactgtacaaataaagaaaaatacaggatagtttcacttataaacatagatgttaaact
cctaaataaaatattatctaatcaaatacgaaagtgtattacaaatacatcatgataaag
taattcaccacattagtcgattgtggaagaggttactagtgctcaccagtctctcgttct
tttcctcctgggaacaccaccaggctacatttcccagccaccttacaattaggtgagacc
catgagactagtccatgccaatggaatgtgaatggaagtgcatctaattttctggctcat
gaaaacagcagcattttctctattttctttttttctttctttgttttttttagacggagt
ttagctcttgttgccgaggctggagtgcagtggcgcgatcttggctcactgcaacctccg
cctcccgggttcaagcaattctcctacctcagcctcccaagtagctgggattacaggcat
gtgccacaatgcctggctaattttgtatttttagtagagacggggtttctccatgtttgt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-135
caggctggtctcaaactcccgacctcaggtaatcagcccgcctcggcctcctgaagtgct
gggattacaggcgtgagccaccgtgcccggcaagagcagcattttctaaaagcaatcagt
actcaacaccatcctgctgaggtagggcagcggcggactc
>IGR2169a
attttgtatttttagtagagacggggtttctccatgtttgtcaggctggtctcaaactcc
cgacctcaggtaatcagcccgcctcggcctcctgaagtgctgggattacaggcgtgagcc
accgtgcccggcaagagcagcattttctaaaagcaatcagtactcaacaccatcctgctg
aggtagggcagcggcggactccatgttttgaaacttaggaacttagaccatcttttgtca
aattcagatggttttctcaaagtaaagatcattcaagttttgtttcagtaatgggccgta
tgatcagatctgtgtgattaggctgaattcattattattgagacaaaaattgagttaaag
gggattcttggtattggcctgcaaaacctgtcataacttaaatgtaaagtttctgatgat
ttagtcactttactctcagctcttagctctttcactcacctgtccttgttctacacaacc
tgcctgatgggtaacttgaatacatattttctctcttcaggggatgggaacgccctaagg
gcaggggctgtttccacagccctggggtggaacccccttcctgcataccaagaatgagtt
ggctatacttgacgaagggcaaagacaaggtggcacgcatctttcatgcttctgctggca
gatgcagtggactggaaatttcctggtctgggaaggactc
>IGR2170a
atacatattttctctcttcaggggatgggaacgccctaagggcaggggctgtttccacag
ccctggggtggaacccccttcctgcataccaagaatgagttggctatacttgacgaaggg
caaagacaaggtggcacgcatctttcatgcttctgctggcagatgcagtggactggaaat
ttcctggtctgggaaggactcggtctgtgagtgcacctatccctgacatctatgctagcc
ccgggatgggggccccagcagagtaaggccctgacttcacatggacagggccagggcaag
ggggccacatcctggcctagttgctctccatgcccgtgatcaagggagatgagctgccag
cttgctcggtcaaggaacacttggaaggcactccaagtgcccccaggtgcaccagatcta
ggaaacttaagcaaactacatgaggtatggggtggggcccagtgggaaaaatgagtctga
caggtcagagggagtagattatgagctcaggttaggcattctgttcagcattttacgtac
accctcccacttttgatttttaccaacacccagggaggtcggtgctctacaaaagggaaa
ggcgtgctcaggtggcccgacttgccacggttccagctcgaccccgggctgctagcccct
tggcacgcttgtctgaggcctcccaggtcttccagcctgg
>IGR2171 a
tatgagctcaggttaggcattctgttcagcattttacgtacaccctcccacttttgattt
ttaccaacacccagggaggtcggtgctctacaaaagggaaaggcgtgctcaggtggcccg
acttgccacggttccagctcgaccccgggctgctagccccttggcacgcttgtctgaggc
ctcccaggtcttccagcctggcctggaggctcaaagccacgaaacccaagggtgccgctt
ctcaggccctccccgcccccacggcagaacccctgaccctgcccgggtcaaacgcctggc
gtcgggcccgccgggtccgcaaggaggagcccgcgaggcggccgcgaaggggctgtgctt
acctcgcccggcgcgggttgcggccccagggcccgcgctccaggctggcggccgctgcat
tctgcgcccctcgcctgaaacggcagctgcgccagtcctggccacgaccgctttcatttt
cctcaacgacatcggcaggaaagcgaaagcgaaaccctccgggaggcgggaccggggccg
agcgcgcagtgaacgcggggcgcgcggcgggcgcgggccggcagccagaggcgggggccc
cgggctcgggtctgcgcgtggcctggcccggtggcgttcggggtggagctgggccagccg
agtgcccgagagctagtccgccacgcacacctgcctcggc
>IGR2172a
aaagcgaaagcgaaaccctccgggaggcgggaccggggccgagcgcgcagtgaacgcggg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-136
gcgcgcggcgggcgcgggccggcagccagaggcgggggccccgggctcgggtctgcgcgt
ggcctggcccggtggcgttcggggtggagctgggccagccgagtgcccgagagctagtcc
gccacgcacacctgcctcggcgggacccgggcccgggctgggcgggaggctgggcaggcc
cgccgtaagtggaaaggcgcccgcggcgcttcggccgaccgggacaggttcctccatctg
cccttcattcagcgtttacttgggcctgtggctggcagccggcccgggacctgaccgctg
gcggcgcctcgggctctggcctgaggaggcagatggcagcctgagcaactgggaccaagc
ctctgaggagtccccgttggaggggacttgaccatgaggtaccaggcatctcatctgggg
tcagcggagaacccaaaagtcaatgacgtcggtgaaatgggggtcccttcatccgataag
agaaactggaacagcaagcctatggtttggactccctggtctaagcggtgcccatcaata
tctaaacatttagagattccaggtttcagtgtctggccgtctcttactgtcagtgatttg
gggcaaaatattcaagtagttagacttaattacttcccct
>IGR2173 a
tcaatgacgtcggtgaaatgggggtcccttcatccgataagagaaactggaacagcaagc
ctatggtttggactccctggtctaagcggtgcccatcaatatctaaacatttagagattc
caggtttcagtgtctggccgtctcttactgtcagtgatttggggcaaaatattcaagtag
ttagacttaattacttcccctgtgggatgggaataataataatcatacctactgccagaa
ttttaggaatgaacaatagaaggaagaaaatacttaaaattttctgacagcctctaagtg
ggttccttgagggcagcaaccaagtcatttacctggatgcttgatagacattctctaatg
gccagtccatcaacttggagctatctccatgataacaggttagttgtcaaagtttggaca
atattatctggagtttaaagactgaggaagccctgcaattttttttggaaggtgtctgaa
acttagcctgacaattagcccccacaattatgccacggaaccaggtttttgttagagtgg
agcatggccacaacgtttgatggacattcctacagcggtgttcagcgctggccactgagg
tctgaaaatacttttgcaagcatttctattcacttgcttttagaaaacattggtaagaca
ccatactccaaacacagtttgccctgtctgtacgtttgtt
>IGR2174a
ccccacaattatgccacggaaccaggtttttgttagagtggagcatggccacaacgtttg
atggacattcctacagcggtgttcagcgctggccactgaggtctgaaaatacttttgcaa
gcatttctattcacttgcttttagaaaacattggtaagacaccatactccaaacacagtt
tgccctgtctgtacgtttgttgcaaagcaaacataaaagtttttgccatagagcaaacac
agagcagtctgttataactggaacaagaaaccaaaatgagctattaaatctgcccagagt
cactttggtttacctgtttgtaatttgggcacattccctgcaagatggaggccctggtct
gtgactgatgtaggggcttgtatgtgtccttgcaatagttccctcaagagcaggtgggaa
agtggggcaggccaaatgatgaccttagaaaaacaacagcctgtttctctgtccagaaga
tgctacttttagtctgtagtatgaaggaaaaagaaaaaacaaaaaaggcaagccttggag
cctcttcctccttataggacaattcttgactccaagatagcaaagtagagttaaatctgc
ttctgcataaaaactatgtttgggaagatgaagatcaggaaaagacaggaagagatgtaa
gcagataagccaaatcctggttaccttttatagacatcac
>IGR2175a
tatgaaggaaaaagaaaaaacaaaaaaggcaagccttggagcctcttcctccttatagga
caattcttgactccaagatagcaaagtagagttaaatctgcttctgcataaaaactatgt
ttgggaagatgaagatcaggaaaagacaggaagagatgtaagcagataagccaaatcctg
gttaccttttatagacatcacacatgtgaacagagagcatcaggaggtcaaggccggcct
gatgtttttcatcttggcaacttcccaaggtccaggtttggtccttgactttgtggggcc
aaaaatctcgtctgacttccagtgtaccagagtcgattagcactgttgcataaagtcaga
atgacaactgactgatttcattcactatttgctagagaagtgctatgctaaatgcattac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-137
atgcattattacctcattatttctccctactatcatgtggtatattataatctatttatt
tttcatttgggagaaaaaaagatgaaggaaatcccaaggtcacatggttactatgtatgt
tagtggcagggtttgaatcaaggccatctgaccccaaaacctgaagcttatccattcctg
ttagaagcaagactgtcgggaacactggactcgaggccacctgatgaacacattctcttc
ttgtagccatgcagtttggagccccatagtcagaaggtgg
>IGR2176a
agatgaaggaaatcccaaggtcacatggttactatgtatgttagtggcagggtttgaatc
aaggccatctgaccccaaaacctgaagcttatccattcctgttagaagcaagactgtcgg
gaacactggactcgaggccacctgatgaacacattctcttcttgtagccatgcagtttgg
agccccatagtcagaaggtggcttagtgagcctaaaatcagaatcggaagagtgaattgt
ctgacttaaatgtttgatgatatcaggctcgggcaatgtgggatgtctctttccacaaca
caggtcaaaacctataggaagtactgttcactcatccctgctggcctggccagcccttct
ccctagatggggcctggtggacaccatctgtttgtgtcaatgaggctctctgtattatgg
tacccaggccgcctctcctcagatggacatttttagatagagcaaggcgttactgagtaa
cattactcagtaaggtctcgcagcccttatttttctttatggagacattttgtatctttg
ctctgattggcttgatttataatttaacttctaaaggacagctttctatcccaccttttg
gagacagctctgttttccttactatccttcctgatctaaccctggaacaaaagtttgtgc
agtagcaagttctgcaacaagaactttatccaggcctgca
>IGR2177a
gcagcccttatttttctttatggagacattttgtatctttgctctgattggcttgattta
taatttaacttctaaaggacagctttctatcccaccttttggagacagctctgttttcct
tactatccttcctgatctaaccctggaacaaaagtttgtgcagtagcaagttctgcaaca
agaactttatccaggcctgcactgatagtcagtaaagacacaaaagaagcaaaagtccaa
gtccaaggccagtcccaaaagactttactacagaatcgggcaatggagggttggggggcg
gggcacagctgatgatcacgcaacccagctgaagaatgatataaatggaatgaaagcatg
gtgcaagcagcatctaacttaggagtcactggttaggaaaaaaaaatacctgatgtgtga
ttcagataaaaatgaaaaaaataacccttttagatatttcattcaacaaatattctgtgg
caactacaaaatgcagccaccctgctaatgctggggattcagtgatgagcaaaaataaat
gtggtctctgccctcgggaaacacacttgagtgaggtaataaagcaatcaaataattggt
caaatatagaatgccatcctaaatactacaagatgcgtttgacgctataagagggaatgc
cagaggcaaaactcctctaatgggccacctgtactctggg
>IGR2178a
ccctgctaatgctggggattcagtgatgagcaaaaataaatgtggtctctgccctcggga
aacacacttgagtgaggtaataaagcaatcaaataattggtcaaatatagaatgccatcc
taaatactacaagatgcgtttgacgctataagagggaatgccagaggcaaaactcctcta
atgggccacctgtactctggggcttcctgtcagtctggccagcactttctcagaatggct
ctgcagtctgaggctcttcctatctactcctccatccttccctcttctctttcacagggg
tcagacctgcattacggtgtggggctctctctgcttactcttgcttctgctcctctttat
tcttcataggcattttccccaataaactcttccaggtttaattccatcttggtgtctgct
ctaggaggacccaagctgacacaatgatgcccttcattgacttggagaaccttggaagag
gcccaagttttggagggctccaattctgcacatgttggcttaggtgtcaggtgggcaagg
aagctccatatctgctttcccactcagaagataatgcttgtgctttggtactaagctatc
aaccatgtcctctgtgggagctagggtctggtcttgtttttaaaatgcttgttccatgga
taatcagcaattctcagtttagatctcaatactagaacta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-138-
>IGR2I79a
ccaattctgcacatgttggcttaggtgtcaggtgggcaaggaagctccatatctgctttc
ccactcagaagataatgcttgtgctttggtactaagctatcaaccatgtcctctgtggga
gctagggtctggtcttgtttttaaaatgcttgttccatggataatcagcaattctcagtt
tagatctcaatactagaactatttccctctagaaaagcacaacctaccaatagcaaaaaa
catcccttaacttccttgaggaggagttaaaagtcaaaaaatcgaaaggagatgagcaat
tgttcctgaacagccaaagggaaataattttgatgtaggggggcccttagttttctggga
aaaggaagtctttttttttttttttttttttgagatggagttttgctcttgttccccagg
ctggaatgtgatggtgtggtcttggctcactacaatctctgcctcccaggttcaagtgat
tcttctacctcagcctcccaagtagctgggattacaggcacccgccaccacacctggcta
atttttgtatttttagtagagacagggtttccttatgttggccaagctggtggcgaactc
cagacctcaggtgatccacccacctcagcctcccaaagtgctgggattacaggtgtgagt
cactgcacccggcctggaagtcatcttttataagtgttcc
>IGR2180a
aagtagctgggattacaggcacccgccaccacacctggctaatttttgtatttttagtag
agacagggtttccttatgttggccaagctggtggcgaactccagacctcaggtgatccac
ccacctcagcctcccaaagtgctgggattacaggtgtgagtcactgcacccggcctggaa
gtcatcttttataagtgttccttaaggaaagaacttacatgtttggcagcacagatggaa
atctgtcattgttggtagaaagaagctagcactccaaaaggcacttttgctctgagctta
gcctccctgagcaaggtgcccttggagagctgggtgtcaaaggatgaccctgtcactgag
gttcagtcaccagcaacctgttgtgagtgaatcatctgtttgaaggcagagctcttcagg
tccaccgctggttcttcccatggaaggaggcttgaacacaaatcatgagtactacatgaa
tatttgaacgtggcactcagtcatagtcaagtatagcatttccctcaccaactgcacacc
ccagggagcccatatccatctcatggtggtgtggaggctgacagtaggcgagtttacatg
ctttgttcccaagctgtcaggaagcccagatactattagtctgcttggtctaaaaagaga
aagaagtaggtgtgggcttcatgaaggatgttttgctgag
>IGR2181a
gtcatagtcaagtatagcatttccctcaccaactgcacaccccagggagcccatatccat
ctcatggtggtgtggaggctgacagtaggcgagtttacatgctttgttcccaagctgtca
ggaagcccagatactattagtctgcttggtctaaaaagagaaagaagtaggtgtgggctt
catgaaggatgttttgctgagggctgtgtctctcattcaaggatgaatgagtaaaagcat
ttgttaagttttttttttttaaaactaccaaatgtacagtgagtgtactacttaagcacc
ttagggataagcctgtcttttccgccaaaggtagttacaatttccctcatggaaccaagc
ataatatgataaggactaattatttgtagagtcaataattacattataatttacacgcat
gatctaatttaatctttatagaaacctgatataggtaaggaattttacagttgaggaaac
agtctcaggaaagttaagtgacttccccaaagttatagagctagtaagtgaagacatcta
cttttggaccatatactttatctactctggatctgggcacttagccaaagccatagtgcc
tccaagaaagaggatgtcatggggtaaaccttgaacatgaatagaattgggataatcaga
gatgaagcaggacaacgtatggatggaggcaggagtgtca
>IGR2182a
gacttccccaaagttatagagctagtaagtgaagacatctacttttggaccatatacttt
atctactctggatctgggcacttagccaaagccatagtgcctccaagaaagaggatgtca
tggggtaaaccttgaacatgaatagaattgggataatcagagatgaagcaggacaacgta
tggatggaggcaggagtgtcaaggagaaatagagagctaaaagtgtgtcatatcaggagt
tgaaatgcattaaaaatatgtgaagtttggacccttttatcgtaatataatgaccttctt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-139-
tgtcttgttaaaatctatttgtctgatattaatacagccattcaaactctcttttggtta
tttgtatggaagatctttccaaccttttaattttcaacctatttgtgtctttgaatctaa
attgaaactgttgtagacatcataatagttgcatcatgattttaaaatctatttggtgaa
tctctgccttttaattgaagagttacatttaatataattactgaaaagggcttactcctg
ccattttgctatttgttttctatgtcttttatcttttttgctcctcaattccttcattac
tgctttcttttgtgttaaatccatattttctaggataattctaaatctgtatctttttaa
agtatatattatttatttattttcttaataattgccctag
>IGR2183a
gagttacatttaatataattactgaaaagggcttactcctgccattttgctatttgtttt
ctatgtcttttatcttttttgctcctcaattccttcattactgctttcttttgtgttaaa
tccatattttctaggataattctaaatctgtatctttttaaagtatatattatttattta
ttttcttaataattgccctagagattacagttcatatattaatttgtaacaacctggttt
agattaataccaagttaatttcaataatatgcaaacactttgttcttattcagctctact
ccctttatattatatttccacaaattacatctttacacattgtatgcccatcaacctaaa
tttttaattattgctttatgcagttgtcttttaaaattatgtaggaaaagagaggttagg
aaaaaaattaatactgccctttatatttacttaggtagctacctctccccatgttcatta
ttccttcatgcagattcaagtattcaagttactggccagtgtcctttcattttagcctga
aagactccctttagcatttttttttttttttgagatggagtctccttgttctgttgtcca
ggctggagtgcagtggcacaatctcagctcactgcaacctctgcctcccaagttccagtg
attctcgtgcctcagcctcccaagtagctgggattacaga
>IGR2184a
gtattcaagttactggccagtgtcctttcattttagcctgaaagactccctttagcattt
ttttttttttttgagatggagtctccttgttctgttgtccaggctggagtgcagtggcac
aatctcagctcactgcaacctctgcctcccaagttccagtgattctcgtgcctcagcctc
ccaagtagctgggattacagacatgtgccaccagcctggctaatttttgtatttttagta
gaggcagagtttcaccatattgaccaggctggtctcaaactccaaacctcaggtgatctg
cccaccttggcctcccaaagtgctgggattacaggcatgagccactgtgcctggcccttt
agcatatttttttaagtactttaagttctagggtacatgtatacaatgtgcaggtttgtt
acataggtatacatgtgccatgttggtttgctgcacccatcaacttgtcatttacattag
atatttctcctaatgctacccctccctcagcctcccaccccctgacaggccctggtgtgt
aatgttccctgccctgtatccatgtgttctcattgttcaattcccacctatgagtgagac
catgtggtgtttggttttctgtcgttgtgagagtttgctgagaatgatggtttccagcct
atccatgtccctgcaaaggacatgaactcatcctttttta
>IGR2185a
ccctccctcagcctcccaccccctgacaggccctggtgtgtaatgttccctgccctgtat
ccatgtgttctcattgttcaattcccacctatgagtgagaccatgtggtgtttggttttc
tgtcgttgtgagagtttgctgagaatgatggtttccagcctatccatgtccctgcaaagg
acatgaactcatccttttttatggctgcatagtattccatggtgtatatgtgccacattt
tcttaatccagtctatcattgatgaacaactgggttgcttccaagtctttgctattgtga
atagtgccacaataaacatacgtgtgcatgtgtctttatagtagcatgatttataatcct
ttgggtatatacccagtaatgggatggctgggtcaaatggtatttctagttctagatcct
tgaggaatcgccacactgtcttccacaatggttgaactaatttacactcccaccaacagt
gtaaaagctttcctatttctccacatcctctgcagcatctgttgtttcctgactttttaa
taatcgccattctaactggcgtgagatatctcattgtaattttgaattgcatttctctga
tgagcagtgatgatgagcattttttcatgtgtctattggttgcataaatgtcttcttttg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-140
agaagtgtctgttcatatacttttcccctgtttgtttttt
>IGR2186a
tccacatcctctgcagcatctgttgtttcctgactttttaataatcgccattctaactgg
cgtgagatatctcattgtaattttgaattgcatttctctgatgagcagtgatgatgagca
ttttttcatgtgtctattggttgcataaatgtcttcttttgagaagtgtctgttcatata
cttttcccctgtttgtttttttcttgtaaaattgtttaagttctttgtagattctagata
ttagccctttttcagatgggtagattgcaaaaattttctcctgttctgtaggttgcctgt
tcactctgatggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatt
tgtcatttttggcttttgttgccattgcttttggtgttttattcatgaagtccttgccca
tgcctgtgtcctgaatggtattgtctaggttttcttctaggtttttatggtgtttttttg
tttgtttgtttttgttttttgagacagtctcactctgtcgcccaggctagagtgcagtgg
tgcaatctcggctcactgcaacctccgacttctgggttcacaccattctcctgcctcagc
ctcccgagtagctgggactacaggcacccaccactacgcctggctaattttttatatttt
tagtagagatggggtttcaccatcttagccaggatggtct
>IGR2187a
tgagacagtctcactctgtcgcccaggctagagtgcagtggtgcaatctcggctcactgc
aacctccgacttctgggttcacaccattctcctgcctcagcctcccgagtagctgggact
acaggcacccaccactacgcctggctaattttttatatttttagtagagatggggtttca
ccatcttagccaggatggtctcgatctcctgacctcatgatccgccctcctcagcctccc
aacgtgctgggattacaggcgtgagccactgcgcctggcaggttttcatcgttttagatc
ttaacgtctaagtctttaatccatcttgaattaatttttgtataaggtgtaaggaaggga
tccaatttcagctttctacatatggctagccagttttcccagcaccatttattaaatagg
gattcctttccccatttcttgttatttcttgtttttgtcaggtctgtcaaagatcaaatg
gttgtagatgtgtggtgttatttctgaggcctctgttctgttgcattggtctatatatct
gttttcgtaccagtgccatgctgttttggttactgtagccttgtaatatagcttgaattc
agacagcgtgatgcctccagctttgttctttttgcttaggattgtcttggctatgcgggc
tcttttttggttccatatgaactttaaagtagttttttcc
>IGR2188a
atttctgaggcctctgttctgttgcattggtctatatatctgttttcgtaccagtgccat
gctgttttggttactgtagccttgtaatatagcttgaattcagacagcgtgatgcctcca
gctttgttctttttgcttaggattgtcttggctatgcgggctcttttttggttccatatg
aactttaaagtagttttttccaattctgtgaagaaagtcattggtagcttgatggggatg
gcattgaatctgtacattaccttgggcagtatggccattttcacgatattgagtcttcct
atccatgaacatggaatgttcttccatttgtttgtgtcctcttttatttcactgagcagt
ggtttgtagttctccttgaagaggtccttcacatcccttgtaagtcggattcctaggtat
tttgctctctttgtagcaattgtgaatgggagttcactcatgatttggctgtttatctgt
tattggggtataggaatgcttgtgaattttgcacattgattttctaacctgagactttgc
tgaagttgtttatcaacttaaggagattttgggctgagatgatggggttttctaaatata
caatcatgtcatctgcagacagggacaatttgacttcctcttttcctaattgaataccct
ttatttctttcccttgcctgattgctctgcccagaacttc
>IGR2189a
ttgtgaattttgcacattgattttctaacctgagactttgctgaagttgtttatcaactt
aaggagattttgggctgagatgatggggttttctaaatatacaatcatgtcatctgcaga
cagggacaatttgacttcctcttttcctaattgaataccctttatttctttcccttgcct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-141-
gattgctctgcccagaacttccaacaccatgttgaataggagtggtgagagagggcatcc
ttgtcttgtgctggttttcaaagggaatgcttccagtttttgcccattcattatgatatt
ggctgtgggtttgtcataaatagctcttattattttgagatacattccatcaatacctag
tttattgagagtttttagcatgaagggctgttgaattttgtcaaaggccttttctgcatc
tattgagataatcatgtgttttttgtcattggttctgtttatatgatgcattacgtttat
cgatttgtgtatgttgaaccagccttgcatcccagggatgaagccaacttgatcatggtg
gataagctttttgatgtgctgctggattcagtttgccagtattttattgaggatttttgc
atcgatgttcatcagggatattgatataaaattctctttttttgttgtgtctctgccagg
ctttggtatcaggatgatgctggcctcataaaatgagtta
>IGR2190a
cagccttgcatcccagggatgaagccaacttgatcatggtggataagctttttgatgtgc
tgctggattcagtttgccagtattttattgaggatttttgcatcgatgttcatcagggat
attgatataaaattctctttttttgttgtgtctctgccaggctttggtatcaggatgatg
ctggcctcataaaatgagttagggaggattccctctttttctattgattggcatagtttc
agaagaaatggtagcagctcctctttgtacctctggtagaatttggctgtgaatctgtct
ggtcctggcctttttttggttgataggctattaattattgcctcaatttcagagcctgtt
attagtgtattcagagattcaactttttcctggtttagtctagggaaggtgtacgtgtcc
aggaatttatccatttcttctaaattttctagtttatttccgtagaggtgtttaaagtat
tctctgatggtagtttgtatttctgtgggattggtggtgatatcccctttatcatttttt
attgtgtctatttgattattctctctttttttctttattagtcttgctggcagtctatca
attttgttgatcatttcaaaaaactagctcctggattcattgattttttttgaagggttt
tttatgtctctatctccttcagttctgctctgatcttagt
>IGR2191 a
tttctgtgggattggtggtgatatcccctttatcattttttattgtgtctatttgattat
tctctctttttttctttattagtcttgctggcagtctatcaattttgttgatcatttcaa
aaaactagctcctggattcattgattttttttgaagggttttttatgtctctatctcctt
cagttctgctctgatcttagttatttcttgccttctgctagcttttgaatttgtttgctc
ttgcttctctagttcttttaattgtgatgttagggtgttgattttagatgtttcctgctt
tctcttgtgggcatttagtgcataaatttccctctacacactgttttaaatgtgtcccag
ggatgctggtgcgttgtatctttgttctcattgttttcaaagaacatctttatttctccc
ttcatttcgttattcatccagtagtcatttaggagcaggttgttcagtttccatgtagtt
gttcagttttgagtgagttccttaatcctgagttctaatttgattgcactgtggtctgag
agacagtttgttgtgatttctgtacttttacatttgctgaggagtgctttgcttccaatt
acgtgttcaattttagaataagtgtgatgtggtgctgagcagaatgtatattctgttgat
ttggggtggagagttctgtagatgtctattaggtccactt
>IGR2192a
ccttaatcctgagttctaatttgattgcactgtggtctgagagacagtttgttgtgattt
ctgtacttttacatttgctgaggagtgctttgcttccaattacgtgttcaattttagaat
aagtgtgatgtggtgctgagcagaatgtatattctgttgatttggggtggagagttctgt
agatgtctattaggtccacttggtgcagagctgagttctagtcctggatatccttgttga
ttttctgtctcattgatctgtctaatattgacagtggggtattaaagtcttccattatta
ttgtgtgggagtctaagtctctttgtaggtctctaaggacttgttttatgaatctgggtg
ctcctatattggctgcatatatatttaggatagttagctcttcttgttgaattgatccct
ttaccattatgtaatggccttctttgtttcttttgatctttgttggtttaaagtctgttt
ttatcagaaactaggattgcaacccctgcttttgttttccatttgcttggtagatcttcc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-142-
tccatcccttcattttgagacaatatatatgtctttgctcatgagataggtcttctgaat
acagcacactgatgggtcttgactctttatccaatttgccagtctgtgttttgtaattgg
ggcatttagtccatttacatttaaggttaatattgttatg
>IGR2193 a
caacccctgcttttgttttccatttgcttggtagatcttcctccatcccttcattttgag
acaatatatatgtctttgctcatgagataggtcttctgaatacagcacactgatgggtct
tgactctttatccaatttgccagtctgtgttttgtaattggggcatttagtccatttaca
tttaaggttaatattgttatgtgtgaatttgatcctgtcattatgatgttagctggttgt
tttgctcgttagttgatgcagtttcttcctagcattgatggtctttacaatttggcgtgt
ttttgcagtggttggtacaagttgttcctttccacgtttagtgcttccttcaggagctct
ttaaggcaggcctggtggtgacaaaatctctcagcatttgcttgtctggaaaggatttta
tttctccttcacttatgaagcttagtttggctggatatgaaattctgggttgaaaattct
tttctttaagaatattgaatattgaatagtggcccccactctcttctggcttatagggtt
tctgcagagagatccactgttagtctgatgggcttccctttgtgggtaacccaacctttc
tctctggctgcccttaacattttttccttcatttcaaccttggtgaatctgacaattatg
tgtcttggggttgctcttcttgaagagtatctttatggtg
>IGR2194a
tattgaatagtggcccccactctcttctggcttatagggtttctgcagagagatccactg
ttagtctgatgggcttccctttgtgggtaacccaacctttctctctggctgcccttaaca
ttttttccttcatttcaaccttggtgaatctgacaattatgtgtcttggggttgctcttc
ttgaagagtatctttatggtgttctctgtatttcctgaacttgaatgttggcctgccttg
ctaggttggggaagttctcctggttaatatcttgaagagtgttttccaacttggttccat
tctccctgtcactttcaggtacaccaatcaaacctaggtctggtcttttcacatagtccc
atatttcttggaggctttgttcgttccttttcattcttttttctctaatcttgtcttcac
gctttatttctgatatcctttctcccgctagattgattcagctatggatacttgtgtatg
cttcacaaagttcttgtgtgtgtttttcagctctatcaggtcgtttatgttcttctctaa
actggttattctagttagtaattcctctaaccttttttcaaggttcttagcttccttgca
ctgggttagaacatgctcctttagctcagggggtttgttattacccaccttctgaaggct
gtcatttcgtcaaactcattctccgtctagttttgttccc
>IGR2195 a
gtgtttttcagctctatcaggtcgtttatgttcttctctaaactggttattctagttagt
aattcctctaaccttttttcaaggttcttagcttccttgcactgggttagaacatgctcc
tttagctcagggggtttgttattacccaccttctgaaggctgtcatttcgtcaaactcat
tctccgtctagttttgttcccttgttggcgaggagttgtggtcctttggaggagaagagg
cgttctggtttttggaattttcagcctttttgcactggtttttcctcatcttagtgcatt
tatctatctttggtctttgatgttggtgaccttcggatggggtttttgtgtggacgtccg
ttttcttgatgttgatgttgatgctgttcctgtttgctagttttccttctaatagtcaga
cccctctgctgcaggactgctagagtttgctggagatccactccagaccctgtttgcctg
ggtatcaccagcagaggctgcagaacagcaaaaatttctgcctgttcctacctctggaag
cttcgtcccagaggggcaccccccagatgccagccagagctctcctgtatgaggtgtctg
tcgacccctgttgggaggtgtctcccagttcggaggctcgggggtcagggacccacttga
ggaggcagtctgtcccttagcagagctcaagtgctgtgct .
>IGR2196a
gcagaacagcaaaaatttctgcctgttcctacctctggaagcttcgtcccagaggggcac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-I43-
cccccagatgccagccagagctctcctgtatgaggtgtctgtcgacccctgttgggaggt
gtctcccagttcggaggctcgggggtcagggacccacttgaggaggcagtctgtccctta
gcagagctcaagtgctgtgctgggagatccgctgctctcttcagcgccggcaggcacaac
atttaagtctgctgaagctgcacccactgctgccccttcccccaggtgctctgtcccaag
gagatgggaattttatctataagcccctgactagggctgctgcctttctttcagagatgc
cctgcgcagagaggaggaatctagagaggcagtctggctacagcggctttgccagactgc
agtccctgggggctttgtttacactgtgaggggaaaactgcctactcaagcctcagtaat
ggtggacgcccctcccaccaccaagctcaagagtcccaggttgacttcagacagctgtgc
tggcagcaagaatttcaggccagtggatcttagcttgctgggctccatgggggtgggatc
cgctgagcaagaccacctggctccctggcttcagccccctttccgggggagtgaatggtt
ctgtctcactggtgttccaggcatcactggggtatgaaaa
>IGR2197a
accaagctcaagagtcccaggttgacttcagacagctgtgctggcagcaagaatttcagg
ccagtggatcttagcttgctgggctccatgggggtgggatccgctgagcaagaccacctg
gctccctggcttcagccccctttccgggggagtgaatggttctgtctcactggtgttcca
ggcatcactggggtatgaaaaaaaactcctgcagctagcttggtgtctacccgaatggcc
gccctgttttgtgcttgaaacccagggtctggagatgtaggcacccaagggaatctcctg
gtctgcgggttgcgaagactgtggcaaaagcatagtatctgggccagagtgcactgtttc
tcatggcacagtccctcatggcttcccttggctaggggagggagttccctgtccccttgc
acttcctgggtgaggcgatgccccaccctgctttggcttgccctccgtgggctgcaccca
ctgtctaactagtcccaacgagatgagccgggtacctcagttggatatgcagaaatcacc
caccttctgcgttgatctcgctaggagctccagaccagagctgttcctggggctttaacg
tttttagtgctcatttgtttggcatggggtggggggcaattctatgaggacatttagaat
tttcagaactattttgctcataatcaggggttgcatgagc
>IGR2198a
gagatgagccgggtacctcagttggatatgcagaaatcacccaccttctgcgttgatctc
gctaggagctccagaccagagctgttcctggggctttaacgtttttagtgctcatttgtt
tggcatggggtggggggcaattctatgaggacatttagaattttcagaactattttgctc
ataatcaggggttgcatgagcattaagtttcaaatctcttcagtagacgaaccatgcaaa
ataccaatatcactgtgtattagtatttagcagtcttatccttgatgtggagtgtatcct
cacacttcctctatgagaagtcttttgtgagacttattcccaggtaaagagccagtcagg
ggcctggctgctgccctctggctggcgcaacagacagatgatgtcccagtgtctctggcg
gcttcttacagaactctgtccctgaggttatgtcccttcttcatgaggtgacaccttcag
gggtgggtctgcctgagagctccaaaacatgatttctgctgagaaacctgtgtctgtcat '
cagtgcatcctctgttaatctcatgagattttattttccaaagtgcttttaaagcaatgg
catagaacataaggtgttgccagtgcattgcatcaagcctctatcagcctaaaagccctt
taggaaaagaattaaaagacaaacccccagaagaaagttc
>IGR2199a
ctccaaaacatgatttctgctgagaaacctgtgtctgtcatcagtgcatcctctgttaat
ctcatgagattttattttccaaagtgcttttaaagcaatggcatagaacataaggtgttg
ccagtgcattgcatcaagcctctatcagcctaaaagccctttaggaaaagaattaaaaga
caaacccccagaagaaagttctattgtgctatttactacctggcagggaatagggtcttg
tgcccacctcattgaccgtcacttagaccaggtattaagcagaataattctctttgacaa
acaacagccttatggaatccatgagaatgttcagggaaccctgacagagataagaattag
tttccaagaataggaaaagatggtatggcaaatctttgcctttactttgatctgtggcag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-144-
gaaactggtttttaagaaaatctgggttgttcctccacctccttttctttgtcttttata
tttctgtgggtatgctggtttctagttatacacattaactgaacacctcatcactcacca
actctgcccctgtggctacagtttgtgtatgcctctctcctggagcagaggagatccttg
gtctgataacacactcagtcttcccaaagtcatggctctaagggaaacaagccacacacg
aatccaacaggcttcgacagaggacttggaattccacatg
>IGR2200a
ttctagttatacacattaactgaacacctcatcactcaccaactctgcccctgtggctac
agtttgtgtatgcctctctcctggagcagaggagatccttggtctgataacacactcagt
cttcccaaagtcatggctctaagggaaacaagccacacacgaatccaacaggcttcgaca
gaggacttggaattccacatgcttggctcaaccctggaagtgacttgggctcttgcctca
ccacatgaagagctctaagcattcaggtaattatggtttttgccctcagaaggccacaaa
tgactggaatcagtggcatggagaataagagagaaaatgcagaaactattcactcctgct
acaggacaatgggtagacagaactgcaattcagattctagagcccctgggaagacagtta
atcagtagtccagcacagaaccatgtttgaggagagtggagaagccaacagtgttccaga
agacgtgctgccttccttctcccccaagtttgatgctgcttgttttgttatgcaacatgc
ccttgagtttctatccaacactggagctttttacccaggtccatccacaccttctagccc
aaaatgccctgtgcaaattgtatatagattaagacacctcttgtgcaccacactcaaccc
ccaatcctctcagcccaccacttactccagccactgttgc
>IGR2201 a
tcccccaagtttgatgctgcttgttttgttatgcaacatgcccttgagtttctatccaac
actggagctttttacccaggtccatccacaccttctagcccaaaatgccctgtgcaaatt
gtatatagattaagacacctcttgtgcaccacactcaacccccaatcctctcagcccacc
acttactccagccactgttgcagtgaccagttctgatgggctctggcaacccctacttca
gccctgcaatgtattctctcttgctttctacccacgggacagaacttatttgggactcat
gcatgtgcagcctggaaacatgtggagctgacacctgtgggctgcctttacaaatggatg
ccaacagagaaatgcttcccccttttactcaaggtacagatggtgttgagatgcatttca
taagcttcttctgaagtccttgctggatggagcatccctgcctttggtgctagtcaacct
gaaaatgcatctttgtattcagcctccctccttccctgttctcctcctgtcctttattgc
tgctccctggaatcttgtccccaaagcataaactgcttaactgcacagaagcacttgtct
cagtctctactttcaagggaacccaagatacatttgtgcaagaaggctggctcagcccat
agtcaattaataaagtgaagaattctagtgcacaagaatc
>IGR2202a
cagcctccctccttccctgttctcctcctgtcctttattgctgctccctggaatcttgtc
cccaaagcataaactgcttaactgcacagaagcacttgtctcagtctctactttcaaggg
aacccaagatacatttgtgcaagaaggctggctcagcccatagtcaattaataaagtgaa
gaattctagtgcacaagaatcaaatcttagtcttagagattaatcccaaccattgctaga
attagcccaagctgatacagagaaaaggcagatgacagtgtggcacaggctcactaaatt
ctagaaataaagattctaggcagttgctgatatttaaaaaatcattttacttattaaaac
tttctcatttcccaaggcacttcagtagctttcacaaaaacatgtttgttcttttttaac
caggtgaggcatatgctttaggagtaccatggtaacataatcagcaaagagaagacaatt
acactgaacacaaaatatcacccaataaagttacaggactaaagtgagctactctgaaag
actatgaacacaatttaaatttcttttttgtaatatcctcccatgactaagtatcaagaa
aggaacacacacaatgacactgtttttggcacttagagaagtgctagaggctagggctgg
taaggccttgcaccagtggcagctgcagacaattgccaga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-I45-
>IGR2203a
acccaataaagttacaggactaaagtgagctactctgaaagactatgaacacaatttaaa
tttcttttttgtaatatcctcccatgactaagtatcaagaaaggaacacacacaatgaca
ctgtttttggcacttagagaagtgctagaggctagggctggtaaggccttgcaccagtgg
cagctgcagacaattgccagagtgattctgtgtttaaaaaaaaaaaaaaaaagacacaaa
ccaggaggctaaggaaccagcctttcccaagtgcattctgaagggcaaataacaaggaga
aaaggatacaacaacaaacaaataaacagtaaaacaaaacccacattacagctttgagag
aaaagacaacgttgctcatctctctcacctgataaatttcctttaaaccatacataagac
gctatagtagcaaggaggtttccacagcagtggaaaacaagaatagtagattcaatggag
catttattatgagcctggacaagcccagtgctttgatcagatgtaaacaagtctactcag
tcgtcatgctgagtggtcttaagagctcacacatcagtgcactttgctggtgatctgcat
ctgctcattctgctccatcttcattacctttcactttccctagctctgcgctctcctgcc
ctggggaagcaatgatccagttaatgtcctctgtaactga
>IGR2204a
caagcccagtgctttgatcagatgtaaacaagtctactcagtcgtcatgctgagtggtct
taagagctcacacatcagtgcactttgctggtgatctgcatctgctcattctgctccatc
ttcattacctttcactttccctagctctgcgctctcctgccctggggaagcaatgatcca
gttaatgtcctctgtaactgagaaaaggtaagaatcaaactccttgtgcaattacttcct
tttcctctaaagttcaccactagaggggagtggggaaaggggtgggggacttagacctct
agccttattaggggccttttcaagtagtctaaaattaaaatgtacatttagcatatgctt
ctcacattcctccagatctcactggttctagtgaaaaattaactgctttggaggtgctga
gtccatcattgtaatagttaggacttagatgaagttgtctgtaggtagccccagtgtccc
tagaggaaggtggtgctctagggccatatgtagcctctgagtgtgggtgcccatccagga
gcaagtcagacacaggtcaagaggacaaacagcaaaggcctttgtcactgaaggactcgg
agtctgcacaagctggccatttctggcaagacagtctttcctcttcagtttctcccttac
tggaagcgatgttagaaggctgtgcttttaaggattgtgg
>IGR2205a
agggccatatgtagcctctgagtgtgggtgcccatccaggagcaagtcagacacaggtca
agaggacaaacagcaaaggcctttgtcactgaaggactcggagtctgcacaagctggcca
tttctggcaagacagtctttcctcttcagtttctcccttactggaagcgatgttagaagg
ctgtgcttttaaggattgtgggcctttcttgaccatcttttaacatccttgtgtgacttg
gagtttttctgtgtttcattctataaaaacaagcaaaaatatgtcagtaacacattttaa
aaagatgcctcccagtctccaaacaaacaagaactgaggatatcttccctgggaagagaa
tcctgcagcagattctgaaaggtttcttctagcctctgagttatccagtgcggctactgc
catggagatgtgtatagtgacatgtccacacaggaacagaccagagaggatgggctataa
gtaagcaccttgccatttacaaccctttaatggctaaactagtccatggtgtctgtgaga
gggagtttgcgagtagctctattgtgaggggctcctgagacctggccagacccagaccca
gtgcatcaacactgacagaggaggtcttcttaccctttgactcttagcatctggtcaatg
gtgtctgggagtggggtaccgaagctctctgggagaaaca
>IGR2206a
caaccctttaatggctaaactagtccatggtgtctgtgagagggagtttgcgagtagctc
tattgtgaggggctcctgagacctggccagacccagacccagtgcatcaacactgacaga
ggaggtcttcttaccctttgactcttagcatctggtcaatggtgtctgggagtggggtac
cgaagctctctgggagaaacaaggtgaggatggctgtcaggatggtcagacttcccatga
gaatgtagggcaggaagcggtcgtaggcacctatggcaaagcagacggagcctcaggccc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-146-
agggctgcagttagacttggtctctcatctacccctttatgctcccaggactctggaagg
ggatcactttccttcttggtctcacatctctcacagtctgagcagtcagattagaatctg
gcatctagacaggtttcagaacccagagctggcacaggcatgcccagagcccagcagtgt
tccaccatgcaggggaggagtacaaaggggcggttgcaggagaagagctgggccatgctg
attattcctatttctgggccatgctgattattcttatttaccaaggttgggtttccaagg
aacctgaggtacttgtccagggatggaaataactcttccacctctgcagatgtgtcccag
cccatgtgatctgccttcagattaggcagggtgcttttgc
>IGR2207a
gtacaaaggggcggttgcaggagaagagctgggccatgctgattattcctatttctgggc
catgctgattattcttatttaccaaggttgggtttccaaggaacctgaggtacttgtcca
gggatggaaataactcttccacctctgcagatgtgtcccagcccatgtgatctgccttca
gattaggcagggtgcttttgcttgctttgagatctacatagcatgttcacaaagcactct
gagtactctcaggtgggtgccaccctccctaaagaggtactggctagggatgtgcaggga
aaccacaggtgctatgaagacataattctgagaagagaaaactggagacctgctacataa
aatggcatggggtggatcttcacacaagataaaatcactctatagtgctctaggttataa
taattttacgttcatcagacctcttgcatggacatctttcccctcatgttccttttaaac
tctgattccaagaaatttctccaactaagcacactggctccctaaaccactctgtaggtt
cttaggataaaggaattgtagtctctgatggaaggcctgggatggctaaaacagaaacaa
accctctaatattctcatcaatttctaggtaatctataggttgttttccatttgaaagtg
agggccagtgcactgggacaagaacccttcccggccaaag
>IGR2208a
tccaactaagcacactggctccctaaaccactctgtaggttcttaggataaaggaattgt
agtctctgatggaaggcctgggatggctaaaacagaaacaaaccctctaatattctcatc
aatttctaggtaatctataggttgttttccatttgaaagtgagggccagtgcactgggac
aagaacccttcccggccaaagatccagtactggatggagcccatgtactgtatgaacttg
ttttcctgttaacacgcaacctccagctcacattcaagccagttagtacttccatcccgt
tgctctagtgtgcccttggctcatgggacttaccaaggtaaacgaagtagggagacagga
tgctgcccaggcgggatgctgtggagctgactcccacacccatgtttctcaccactgtgg
gatacagctcggctgtgtacacgtagaccatggaaaaggcagccgtgactccaaacttgc
ccaccatcaccaggactgtagccaaataatacaagtctggagaagcaaaggaaagagggt
aggagtaggtaccaacccatggcatgcagctattgagagcaaaacaaacatactttcttc
ccaaattttttggggagtcagtttctatcacttcctattgtgggggaaggggctatagcc
aagatttccctccaaattgattgctgaaaggaggctggga
>IGR2209a
agccaaataatacaagtctggagaagcaaaggaaagagggtaggagtaggtaccaaccca
tggcatgcagctattgagagcaaaacaaacatactttcttcccaaattttttggggagtc
agtttctatcacttcctattgtgggggaaggggctatagccaagatttccctccaaattg
attgctgaaaggaggctgggacctgcagctataaggacatgcactttcctcaacctggag
accaccagagtaagctccttaatagtccaatcaacctgcttcccagtctataagtcatta
aagacatgtctgtcagggattaactgtcaccccagaacctcacactgcaggcactatgga
attaactcatgatgtttagatgaatggagaattcagttctaactcatttcatgctttcct
cccactcagacctcaaaaaaatcataggccatcagaatctcgagttgatcttctaatctc
tctgtgctgtgctgatgggagagctatgtgtgacctgaaggtcactctgagctcagctgt
gagcctctacatcagttctgggctcctcctgccacatcccatggggagctgttcccgtgc
agtgttctcagcctgatgggcccaaaagtgaccatcagaggctcccaaatctacaggtac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-147
actgaagtctctgggcacagtgatggagagggagagatga
>IGR221Oa
agagctatgtgtgacctgaaggtcactctgagctcagctgtgagcctctacatcagttct
gggctcctcctgccacatcccatggggagctgttcccgtgcagtgttctcagcctgatgg
gcccaaaagtgaccatcagaggctcccaaatctacaggtacactgaagtctctgggcaca
gtgatggagagggagagatgagggcccatgaactgttctataaattattggaaatggcta
cctcccacccatctgtgggatactaagatagtttcagaaataaaatcctgctaagggtct
gtgaggccctctcagtggtctggcccctccccttctccctcctcctcaaacatgccaggc
tcatcccctgctcagggtcgctgcctttgccatttcttcttcctaaaatgttctcctaga
ctttttcagggctttctgtcactttatgtacatttctactgaactgccccctgttcaggg
acactatctgtgactatgtaaactaactcggcattgtccttcatttgtattcctagaagg
taacacagtctgaactatattaagcattttatttacttgtttgttgtctgtcttctcatc
tagggtgtacgttccatgagggcctggggttctgcctggcttgttttcttgtgtatcgtt
atcaccgagcacagtgcccagcccatggtaggcatgccat
>IGR2211a
aaactaactcggcattgtccttcatttgtattcctagaaggtaacacagtctgaactata
ttaagcattttatttacttgtttgttgtctgtcttctcatctagggtgtacgttccatga
gggcctggggttctgcctggcttgttttcttgtgtatcgttatcaccgagcacagtgccc
agcccatggtaggcatgccatagctatttgttgaataaataaagaagacagggccaggaa
aaaaaggaatgggatagctatttcttccctcttcttctgcagtggaaaacagtatgagca
cattaacttgggtacagagtaaaattaaccaacagccccaatggctgctttttcccactc
cctcaaagcccaggccataagtgttctagtctcagaagacactttctattgatttttagg
ccaagaatgtatataagcaagggagctgtgatgggcttgattttattctctttattaatt
gagacagcctggtagacagtaagagactcagtgaagaccccaaaccatagatgcacatgg
tccctacctgggggtaccagctgcatgaagagaaggacactgccacccaggaagagggca
gtggccatggaatagcgccggggcaaatattgcagcagcagccaggccaacacatatgct
gggacttcaaccatcgctgaaaggaagcagttcacaaaga
>IGR2212a
taagagactcagtgaagaccccaaaccatagatgcacatggtccctacctgggggtacca
gctgcatgaagagaaggacactgccacccaggaagagggcagtggccatggaatagcgcc
ggggcaaatattgcagcagcagccaggccaacacatatgctgggacttcaaccatcgctg
aaaggaagcagttcacaaagatgtccccatgcaagttaggagtatcaagcgaaagcccaa
aatagcccactgatatggtcatcctgaaacagagtgcagaagaaagctggaaaagcagta
tccacatctttcccaacctgtacaacttttacaatgcaattatttcagtaaattccaaac
catctttaagcagagactagtaaggcagcagtaactgtaaccctgcgtcttacttcatag
atcaaaagataattttccccagcccaagtggtacagtgtaaaccctgcgccagtgcgctc
tcagagccttccatatagacagtgtcccagcaaaaaagcttgtataattcagatagattt
acttcattgaaaagaaaaattccaacctgcctttcagctttaaaaatcctaagctgaacc
tcctcaaatccagcaactgcagaaggagctagagaatgagtcaggaggcagacatcaa.gt
gaggtgtgataggatttgggggataagataacaaaaggaa
>IGR2213a
cagtgtcccagcaaaaaagcttgtataattcagatagatttacttcattgaaaagaaaaa
ttccaacctgcctttcagctttaaaaatcctaagctgaacctcctcaaatccagcaactg
cagaaggagctagagaatgagtcaggaggcagacatcaagtgaggtgtgataggatttgg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-148-
gggataagataacaaaaggaacaacattaggtcaaacacttggagagagaccctcacaca
ctacctgtggtgaccagtcaggaagaggctggtcagagacagctgacaccagccccgcgg
tacttgtggagcagagaggtggctcccaatggaggggccacactgcctctcatcaggatg
ccctgcagtacccctgacctgggcatccccagtaggcattctctctgttgatgacccaca
ctctttgacaaaccagacctttatggattagactgttttgactcatctgcaggtggaaca
cacagctggtacaataaaaagagtatgtgcatgagtccccaggaaatccagagcagggag
gagagcctgggtgaacacaaaagtgggtgactcatcacaggcttgcatgtctgtggtgca
ggctacatgctgctcctgtcttgaggccaactcagggaatggtgaactgcctggagggat
cctgggccattccttggaagcgggtgactcatagcactcc
>IGR2214a
agagtatgtgcatgagtccccaggaaatccagagcagggaggagagcctgggtgaacaca
aaagtgggtgactcatcacaggcttgcatgtctgtggtgcaggctacatgctgctcctgt
cttgaggccaactcagggaatggtgaactgcctggagggatcctgggccattccttggaa
gcgggtgactcatagcactccctcagtaggcacagtggctgactgcctcaaagctggatg
agactagtaataaggactctgagatgaagtccgccctcctcgcccatcttctcaccgcta
acccaccaggctccagaagtcgcctagaatcccagggttcggccgctgagcaaaagctag
cgatgtgcacttggacatgtttcctctccctggtaattcacaaatccctttctgacatac
tttgcctcattagtgggaacctggtaaggacatctaggctatagccctgactccaggacc
gtttatggacatcccaggaggagcacatcccacttccacatttccagaaagtaactggca
gcctctgcagcctacaggacatggtgtcttcactcagatccttcttaaaagccctacctg
gcctcctcagccactgtcggtaactgggtaggagacgggaactaaatgacccaaattggg
caaggattcatcttaagatctggagagattccccacgaga
>IGR2215 a
ggagcacatcccacttccacatttccagaaagtaactggcagcctctgcagcctacagga
catggtgtcttcactcagatccttcttaaaagccctacctggcctcctcagccactgtcg
gtaactgggtaggagacgggaactaaatgacccaaattgggcaaggattcatcttaagat
ctggagagattccccacgagagtccatatttcccacaacagcctccacaattgttttcat
tctccttttctgaggttccatcccattaagaattgtgacatgcccattttttccatctaa
cacaagacatatccttttcactctctgatgacataggctttgaattttgtctgaggcatg
tctgtaaacaagaggcccaatggccacttcaagaagctttgtctggaagcctcaggcagg
tctcttttacataccacagcattatggacatgatggtgaccatccggatattccaggttc
gaagcagatccagaatgttgtgggactgctgcttcttggaacttaggtcttgtaactgca
ggaacaacatcataagtgtatgggaagaagaggtggtcagagactcagagcacacaataa
catacttgaatccctggcatcttagctgtctgcatctcagcgtcggggagtgttacgttt
ctaagaacagtaagtatactgactgtgttttaggctgtga
>IGR2216a
gtgggactgctgcttcttggaacttaggtcttgtaactgcaggaacaacatcataagtgt
atgggaagaagaggtggtcagagactcagagcacacaataacatacttgaatccctggca
tcttagctgtctgcatctcagcgtcggggagtgttacgtttctaagaacagtaagtatac
tgactgtgttttaggctgtgaaaacttccctaggccttgtcagtaacaaatcagagtgaa
tgaaaatgaggaaaagtaagtgaccagtccctcaagggtacaggaagacagaggcccagg
ctgacagcttcctcactgcacccccacatattcctgtcggtggccacattccaaggaggc
ctctaagtattcctcccgaagcctggctccctgccctctgggtcagagagagtacctggc
tgtgtggtttattggtctgatattttttaaaagttaatgttttgagtccttatactatgt
agttactggtgtgcttccagggaaaaagaattcaaatagaaaaacaggaaaattgacctg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-149-
agcttcacccagagtgacttcctatgaaattcagcacagccaaggccattaataaaccac
acgtctaaacacactgatgttgctttcttaagcaaacccaggtttggagcttgtttttcc
agagttagaagttcaacaaaaggtcaactttggactgaaa
>IGR2217a
gggaaaaagaattcaaatagaaaaacaggaaaattgacctgagcttcacccagagtgact
tcctatgaaattcagcacagccaaggccattaataaaccacacgtctaaacacactgatg
ttgctttcttaagcaaacccaggtttggagcttgtttttccagagttagaagttcaacaa
aaggtcaactttggactgaaagtatcccctgaaatagcctcatttcctcaaagatgccag
tggggcttatgcattcacccagattgacccctcacttaaaagcccccaaaaccacctaac
ttaaaagccctctgccacactcctgcctgacctttgcgcacaggacccctttctggtgca
tgctgacagtggctgctgggccaccactcactgggaagtctgcagggctggcagtggcca
ttggcctccgctgtctacaataactgttccctcttttccaagcccaaccatgcctgcctc
tcacacttcagcagggctgcttgtggctgttcccacacccaacccctcatcttccagtca
gaccacagacacattccagaaccccaccaggcagcatttacagcttctaacctctcatag
tcacgagaccaaggaaaactgcctgctacagagatggtaggagagggaacgggaaggaaa
agcaagaaccaggaactaggtagagccaagaaatgagtca
>IGR2218a
cttgtggctgttcccacacccaacccctcatcttccagtcagaccacagacacattccag
aaccccaccaggcagcatttacagcttctaacctctcatagtcacgagaccaaggaaaac
tgcctgctacagagatggtaggagagggaacgggaaggaaaagcaagaaccaggaactag
gtagagccaagaaatgagtcatggtgtgtgagaacagggctgacgggaggggtggggtag
ggggaagaggtggacatcaaaaaggacctgactccaagatgatatgcaataattaaccat
tggagggcagaaagagactaaacactttttttttctttttaatgaataattgctaatact
caagagatgaaatacttctaactccaaatctatttgtgctttacattttacgtttggggt
tagctttgtaaggtgacaagccaccttaggtataagaaacaatgattttcccaaatgctg
actttatgaaaggcctattactcaaaaagagtatttattgttagaagtaatggttaaaat
atatgattgcctagaaaggaagtaaaaaatgaaaatctgaaacccgtggtgaaaagagtg
aggcagctgtaacctattcctcaacttctgagtgttaacagggcccgtgtgggggtgggg
agtggggggatggggggaatgggcagttggggcttgggca
>IGR2219a
actcaaaaagagtatttattgttagaagtaatggttaaaatatatgattgcctagaaagg
aagtaaaaaatgaaaatctgaaacccgtggtgaaaagagtgaggcagctgtaacctattc
ctcaacttctgagtgttaacagggcccgtgtgggggtggggagtggggggatggggggaa
tgggcagttggggcttgggcagagagagggctgggctgctgtgagcagggaggacttcag
ggctgggtgctgctgctctcaaatcacggtcagtctgtccctctcacccacacccacatg
gtgcttacctcactcgggtcaaagatagtggaaggcacaacaatcccattggctttggca
gccttgcggatgatcacctctgcctcttcaaatcgtccctgagagatgagccatcggggg
gactcagggatgaacctggcagtacaaggtccaatctcagtgaggcctccctgccaacag
cagacccacagaccaggtagagcacagccataggtgggaataaggttgcagaaccagagc
ttgtggaatgtttggtgatcacaagccagaagcaaagagctgatccacacgcagcaataa
cctggggtggatgagcttatgtgtaccccacaccgcacaaaaatgggagagccctgcacc
ccctgacggcatccccatgctggctggccacctccatttc
>IGR2220a
gagcacagccataggtgggaataaggttgcagaaccagagcttgtggaatgtttggtgat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-I50
cacaagccagaagcaaagagctgatccacacgcagcaataacctggggtggatgagctta
tgtgtaccccacaccgcacaaaaatgggagagccctgcaccccctgacggcatccccatg
ctggctggccacctccatttctgaagagcagtgttgccatctgctgggctgaggagatgg
gtgcaagatgggctccggaagcctggcttctgtgcatgtctatgtcagcccaggccctgc
tacactctcctccctgtccccggcaccaacagaagcttctgcactggccttttagcttct
cttctctcctcaccctacccctgatttatccaacagattagtcagatactctacctaaaa
tagcatgtttggccaggtgcagtggttcactcctataatcccagcactttaggaggccaa
ggccggtggatcatttgaggctaggagttccagaccagcctggccaacgcagtgaaaccc
gtctctccaaagaaatacaaaaaaaattagccaagtgcggtggcaggcacctgtagtccc
agctactcgggaggctgagacatgagaatcgcttgaactggggaggcggaggttgcagta
agtggaaatcacgccactgcactacagcctgggcaacaga
>IGR2221 a
gctaggagttccagaccagcctggccaacgcagtgaaacccgtctctccaaagaaataca
aaaaaaattagccaagtgcggtggcaggcacctgtagtcccagctactcgggaggctgag
acatgagaatcgcttgaactggggaggcggaggttgcagtaagtggaaatcacgccactg
cactacagcctgggcaacagagactttgtctgagaaaaaaaaaagaaaaaaaaagaaaaa
gaaaagaaaaaaaggaaaaaaattagcatgtttatcaaggcacttgagtgctctatggat
attattttccaccttgctgggaccaggtagccgccccccaccctcggtcatgactgggcc
ccatgatgtgcggcttactctcccactatgccctgaaatgctctctgctccacttgggct
ggtgatctcaccttctccacctgcaaggggtgattcccaccttagcacctctgcagtgtt
cccctcttggtctggaatggcctcttctctgcctgttcaactcctctaccttggtggtgc
agaaggagcctggcttcctccatgtggctaccctgaggactcttgcttttggtgccagtg
cctgtggcatgaggcttcagcagcacacagccagaactagggcctacactgtcctgccct
gaggcttgggaacttcctacagggcatgctggaccccatc
>IGR2222a
gcctcttctctgcctgttcaactcctctaccttggtggtgcagaaggagcctggcttcct
ccatgtggctaccctgaggactcttgcttttggtgccagtgcctgtggcatgaggcttca
gcagcacacagccagaactagggcctacactgtcctgccctgaggcttgggaacttccta
cagggcatgctggaccccatcttctcacagctactgctatttttccccacacttggggca
acccagcacagggctgagagcaagtctgttgctgtcatgggattctgttttgttttggct
cttttgagtgtggagaaaacattctgaaataatttataatctatgcttcctgtctctggg
agacaaaatagggattcatgggttgttgctgccctctagtgaaggccagacagaaatcat
cctgccagtgggcacatggggcacagggtcacactcaccaccagagtgccacgcacagca
cccccggcatcgtcagcgccaccagcagcatccgccagtctcggatgaagtaagcaaaca
gtggcagcaccatgtagccaaatgcataaaatatgcacactcctaacgtagagaatatta
tacgaactgacttgccaagaatttctgtccctgttcaaaacaagggaggtcgagttagca
gtttaatttgggttccttccttattaattttttatggtat
>IGR2223a
caccagcagcatccgccagtctcggatgaagtaagcaaacagtggcagcaccatgtagcc
aaatgcataaaatatgcacactcctaacgtagagaatattatacgaactgacttgccaag
aatttctgtccctgttcaaaacaagggaggtcgagttagcagtttaatttgggttccttc
cttattaattttttatggtatctttgtgaatacacagacaagaaaacagcgagaactctc
tctaagttcatggcgctagggagcggatggcgttctgaacccctcctgtctgactgtctc
ctgggggtacatccctgtggcctctcaggcccccaagcaacagttctctcttgaaaattt
cgccatgttctgaagccatgtgctaaagatgccatggtaggccccctttaatcctcacat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-ISI
gaggaagaatttattaaaagtgaagtcattactaagtcagcacatgctgacttaagcctc
aaggaaagaatattaaatataaaaagaaaaaacaaccctttcaacaatacaacccaagga
actcaaaggccttatcagctagagtcaggttcctccaaacacaggccggcctggcagctt
ctcagtgacaacaggctggcacatttgagacaaagccctgcagtgtgcactctgaattaa
aaccctgaaggtgacgaaagccccttcctatcaatttatt
>IGR2224a
taaaaagaaaaaacaaccctttcaacaatacaacccaaggaactcaaaggccttatcagc
tagagtcaggttcctccaaacacaggccggcctggcagcttctcagtgacaacaggctgg
cacatttgagacaaagccctgcagtgtgcactctgaattaaaaccctgaaggtgacgaaa
gccccttcctatcaatttattcttgtccgtagatatcaccagccacagtgctctgcagac
aaggggttctctaccttagcaagcttgccagtcacagcccctcctcctccaaccatgccg
ccctctttctggggctggctcagccctgtgcagtggcaggccctttttgtaaatggagga
tctctggtgagtcctagtaaattgactaccaagtactaagaccaaggagccacagcccag
aggccagaaaagaactggaaatcagaagtcaggccattgtgctgctggggaccccaggct
ggtctcatgtctggctcagtttccctgcctgtaagtaaggttcaccaggaagctctggct
agttttgttagaaaccctgtcccccttgagggacatcacagctgtctccagaaaggtagg
tgatgggatgatggtgaaatacaggatcaagtactcaactccaacctgatggccataccc
aggacaaatgctgccacatagttggagatctggcccatgc
>IGR2225a
tttccctgcctgtaagtaaggttcaccaggaagctctggctagttttgttagaaaccctg
tcccccttgagggacatcacagctgtctccagaaaggtaggtgatgggatgatggtgaaa
tacaggatcaagtactcaactccaacctgatggccatacccaggacaaatgctgccacat
agttggagatctggcccatgcctacaaggacaaacagcacgacaaacatctcaaaattct
tcgagaagatctgcaggaagctgaagcctgtctgcatgcccatggtcacgaacagcacat
tcttccggccaaacctgggaagaaaaggagagtgacagataaccagctggaaaagggcag
caggaatgggctccaccaagtggggctttctcaagatccatccagtaagtgggtgtgaac
agtgttgccagaatactggctgccagggacagtctcggtctcacagtgcccatgctattt
ctccccctccccactccccatgacaaatgtacagcctgggtaccagggttgcctaaaaag
caatgctacaattatgataatgattgcaagagactgaaatacatcaattatttaatccat
acattcataatgatattttttttaaaaaagaatctgccaaatttggagaataacagagaa
acaattcattataaatgaaaactggcaaataaagagaaag
>IGR2226a
atgacaaatgtacagcctgggtaccagggttgcctaaaaagcaatgctacaattatgata
atgattgcaagagactgaaatacatcaattatttaatccatacattcataatgatatttt
ttttaaaaaagaatctgccaaatttggagaataacagagaaacaattcattataaatgaa
aactggcaaataaagagaaagaagcatttgtcctgattttcctttgtaaactatgtgaac
agcaaccaataatagataagaggtagtatcatgtacaaaagtattctaacttttaaatga
aaaggtaataaaattagaataataccatttatagcccccaatggattaatagatctatgc
attatatactaattactgttaacatcataaagagacagtcaggaattgcatgcttcctat
ggtcttgccaaaaggactgaacctgaatcagaacctgaatctcaagtctctggatccaac
tgccaattttgaggaaatgcagagcatagaggaatgtgctgaactgcatcatcagtgtgc
aatcaacaaatccagactgggaaattctataggtggaatagctcaggttcttcatagata
atcagtaaggcatagaaggcgatagaaggagaatccatagattaagtagactaaaagaca
tcaaatatattaagtgggcaacactaaatttgtgtcaagg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-152-
>IGR2227a
cagagcatagaggaatgtgctgaactgcatcatcagtgtgcaatcaacaaatccagactg
ggaaattctataggtggaatagctcaggttcttcatagataatcagtaaggcatagaagg
cgatagaaggagaatccatagattaagtagactaaaagacatcaaatatattaagtgggc
aacactaaatttgtgtcaaggatgcatatttcgataataaaactaaaaaaactcacaagg
aagtgattattacaggagtcaggctagcggttacttaatggggagagagagaggatgctg
taattgggatggggcacatggacagggcttcttagtggacagcaaagttctactgctcga
cttggtggtggtcataaggttatttctctgaaaaaaattcattaagctacacatttgttc
tgtgtggttttctgtatccgtgctcattttaaaaagtttttaaaattgggtttattttgg
tttgttttaaagagagtgccacaaacaggaggaaaaagtcaagctagtgggaagcagtgg
gttcagtttgagtctggccagtactggctgacacccactttcattcaatgtttattgagc
atctattatagagggcacttggatatcaataaattaaaaaagatgctgtttctgccctta
aggagtgtcatagtataactggtgaaacacatattaacca
>IGR2228a
cacaaacaggaggaaaaagtcaagctagtgggaagcagtgggttcagtttgagtctggcc
agtactggctgacacccactttcattcaatgtttattgagcatctattatagagggcact
tggatatcaataaattaaaaaagatgctgtttctgcccttaaggagtgtcatagtataac
tggtgaaacacatattaaccacattttaatctaacaacacgctactgaatatacaattac
acactgagtcaagtgcactgaaggatcggcatgcaggttaatgagaggcacaaggaagga
agctaccctggactgggggtaagggttggggaactggacattcagggagggtctccttga
tcatgggacactgagatgggaaaaaatagttgacgatgggggatttaaggtgtagggacc
aagctctcaatgatattcacagtatagtggggaagaccaacattaatcctataataacac
tttttttcccccaatttctggtagacgttttaaaggaaagtcataaggaactagggatcc
tgaattagccagcatggttaaagaaggccacagggggtgggttggggtgggtggggaatg
cttcagactctgagaagaccacacacccccatggctggagggggcatggtgaacatgagg
aaccagtgtggttggcatcaggcgtgcaattcaagagtac
>IGR2229a
ggtagacgttttaaaggaaagtcataaggaactagggatcctgaattagccagcatggtt
aaagaaggccacagggggtgggttggggtgggtggggaatgcttcagactctgagaagac
cacacacccccatggctggagggggcatggtgaacatgaggaaccagtgtggttggcatc
aggcgtgcaattcaagagtacagtggtggctaggaggcaaattgcacaaggtcttgcaac
tatgtggaagagtttggtgtttttcctcaataaaagaggtttttttctgttgttgttttt
tttttccatcacttggggttcactggcatctaatgagtagaggccagatatgttgttaaa
tattctaaaatgcccaggaaaatgccctagaacaaaattatttggctcaaaatgttaata
gggtcgaggttgagaaactctcgcctggtagtagactctactttcccctgcatggttttt
ttaacaagcatgttctatatgccaaccaaggggtggttcctaaccacaaggcaggctggt
ataatctctatgccctttcccttcctaagagctccctgggatggtagggaagagacagat
ccagagaaccctttacatagcaccagtccttggcagttcagggttggggccagaaatgtt
tgcttttaaagtctgtcaacaaaatggcaaacacacacat
>IGR2230a
tgccaaccaaggggtggttcctaaccacaaggcaggctggtataatctctatgccctttc
ccttcctaagagctccctgggatggtagggaagagacagatccagagaaccctttacata
gcaccagtccttggcagttcagggttggggccagaaatgtttgcttttaaagtctgtcaa
caaaatggcaaacacacacatacctggaaacaggacacagcagtctacttcttcctagag
ttgtgcatctcttacaagtcagacgcataaagataactcaatagtgttacataaagggct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-153
ttgacaacccaggagtactttaattgctcttgaatttcagacatattcataggccagaaa
gaaggtgaaacctttatactatataaaaagttacattgatgtcctagacaagttagggca
tgaattgattgctttcaggtaatctacttagcttaggttttagaactggtttactcagaa
gtaatgcactcagaagctgtccatcccacagggccctgggccttccaagggggcacagac
aggcttgaggcagggcattgggaattgaaggcaggggctgcaggcagaacagccatactt
ttagccacttagggtgtatttcatttactagacttaaattatcctactttaatgaaagtt
ctgtggccaaaatgtttagaaaggtttgaaaaacactata
>IGR2231a
tccatcccacagggccctgggccttccaagggggcacagacaggcttgaggcagggcatt
gggaattgaaggcaggggctgcaggcagaacagccatacttttagccacttagggtgtat
ttcatttactagacttaaattatcctactttaatgaaagttctgtggccaaaatgtttag
aaaggtttgaaaaacactatattagcccttctgtagactaaagtggtcctaaacacactc
acaaattttgtttccactttccctgggaatagaccttttggaacttaaatgctttcctca
ggtaatcattgtgtcacatggcaagaaggttcttaagctgacccatgacacagctgaccc
agaaaaatacactgcatttctactctgaacttggggtatctccttttcacatcaagggca
ttcttctgagccgcagctgtcacttagctccgtgagaaggaatctcccatgtccactcag
gtggcctctaagcatagcacaatcctcccccagttcccccctcccctccccactcccctc
tccccaggcaacctcatccctatctggggctctgctgagggttctatatgctgacaaatc
ctacatgtgtttctctagccaaaacctctcatgcagtaccatatccatacagccagcttc
acactctacttctccacttaggggtctcatagtcacccca
>IGR2232a
caatcctcccccagttcccccctcccctccccactcccctctccccaggcaacctcatcc
ctatctggggctctgctgagggttctatatgctgacaaatcctacatgtgtttctctagc
caaaacctctcatgcagtaccatatccatacagccagcttcacactctacttctccactt
aggggtctcatagtcaccccaaatttagtacacacaaattgaactcaatatccatgaacg
tggttcttttccagcattctctgtcttagagaagtgtaccttcattcacccagttactca
ggccagaaagctttcttcccccaattccgacatccagcccatcggcaagtcttgttgatt
ttacctcttaccacttccctccatttctaccaccgtcatgctaggccatgccaccatcat
ctctggcatgaactactgtgacaaccttttaattggtctctctacaacaccttttgcttc
ccttcaattctttcttcacaaggttgtcaaagcatctttaaaaaaaaaaaaaggacaaat
ctgattgtcacactattgctttaaaaaatctcagtagcccaccgctgctctgtggctgaa
gcccaaagtcctaactgtgatccactaagccctggttgctcatctgcccagggctctgcc
tgcctctccccttcatcttaacaccactctccgcacctct
>IGR2233a
aaggttgtcaaagcatctttaaaaaaaaaaaaaggacaaatctgattgtcacactattgc
tttaaaaaatctcagtagcccaccgctgctctgtggctgaagcccaaagtcctaactgtg
atccactaagccctggttgctcatctgcccagggctctgcctgcctctccccttcatctt
aacaccactctccgcacctctaccacacggactttgtcctgctcccatgccttttcatga
gccccggctttagcacttgctattctccctgcctggatgttctttctcctctctacccct
cagctggctactttcgactcatcttcccactctcgctcatgcttcaccttctcagggatg
ctgcccctgacctcctctgttagacactcctgtggcaccctgcacttctctgtatctctt
accatggccaaggacaacaacgacttcctcacttggttgtttaatacattccaccttgct
agaaagcaagttttaggacagcagggacctagaacagtagtccatacacaatagaggagc
aagactacctgggtccaaatcctaactctgccacttgccagctgtgaaaccttggggaag
ttatttaatccctctgtctcactttctccatctgtaaagtaggaataataaacaggttaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-154-
cctgctttttaaaaaaaaatctggctgggcaggtgcagtg
>IGR2234a
agcagggacctagaacagtagtccatacacaatagaggagcaagactacctgggtccaaa
tcctaactctgccacttgccagctgtgaaaccttggggaagttatttaatccctctgtct
cactttctccatctgtaaagtaggaataataaacaggttaacctgctttttaaaaaaaaa
tctggctgggcaggtgcagtggctcgcgcctgtaatcccagcactttgggaggccgaggt
gggtggatcacctgaggtcgggagtttgagaccagcctgaccaacatggagaaaccttgt
ctctattaaaaatacaaaattagctgggcatggtggtgcatgcctgtaatcccagcaact
caggaggctgagacaggagaatctcttgaacctgggaggcagaggttgcagtgagccgag
atcgtgccattgcactccagcctgggtaacaagagtgaaactccttttccaaaaaaaaac
aacaacaataaaaaatatctggctgcgcatggtgtctcacgcctgtaatcccagcacttt
gggaggttatggagggaggattgcttgaggccaggaattaaaaaccagggaagatgctgg
gactcctttccaccggctaacccaccgatttgtggggtgttctcacatgtgccatgtggc
caaggacttgctgaaggctgctactctcttcacagtcttc
>IGR2235a
tggctgcgcatggtgtctcacgcctgtaatcccagcactttgggaggttatggagggagg
attgcttgaggccaggaattaaaaaccagggaagatgctgggactcctttccaccggcta
acccaccgatttgtggggtgttctcacatgtgccatgtggccaaggacttgctgaaggct
gctactctcttcacagtcttctctgacagaccctgaagctccagggaaagaagacacaac
ataatggacccctctaagaacttcatgaaagctacggacctctctccaaaaaaatgctca
catgtagtctctaacattgtgcatataatttcgaggggtttgggattctctaagccgtta
atgtttccttgagttaaaagctttagaattatacaaataacctgcttataagaaatggat
caaaacactattctccctcctgtcataaagtaaatgccaaaaccacaggccacttagcta
aggggcatcagccttgtggacaaaagagttctgcttttcataccactagtggctggtgag
agctcctttcactttgcagagagaatgctggtcttcttgggactacagaggcagacaccg
tggcactactacagatctacaatctagcacatgtgcatgtgtgcatgatgtcaacctctc
ccatgctcaggggcatgacagagtcacagtgacccagggg
>IGR2236a
acaaaagagttctgcttttcataccactagtggctggtgagagctcctttcactttgcag
agagaatgctggtcttcttgggactacagaggcagacaccgtggcactactacagatcta
caatctagcacatgtgcatgtgtgcatgatgtcaacctctcccatgctcaggggcatgac
agagtcacagtgacccaggggaggcaagccaggctactgcagaagtgaatcatggcatat
tacctagtcaaccggatcacagatacattcagcttagacagctcaggtttctttacttag
caagaattacggagtcagatgatttgttggctcttcttactaggcatggagtctatatca
cagacatagcttcctcttctttaaaatacagggccctgcgctgaaagaatactaccaact
gaaatcaagggccaggcacacgcttcttcctcagtgctgaggtcccctggtgctccagaa
gacagacaccttacctgtctgacagctgccctgaaatgaaggagcccaacagcacaccca
cgaagaacaaggagattgtgagtggggccttccagtcgtcctcacacaccaggttccact
gcaagatgagcaaagggggtgtatcattcacttctttttaaaaggttttaaagcaaaggc
atcctggaaaatgaagtcagaacatcctgccatccccaca
>IGR2237a
tgacagctgccctgaaatgaaggagcccaacagcacacccacgaagaacaaggagattgt
gagtggggccttccagtcgtcctcacacaccaggttccactgcaagatgagcaaaggggg
tgtatcattcacttctttttaaaaggttttaaagcaaaggcatcctggaaaatgaagtca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-155
gaacatcctgccatccccacacgctctgagtgtgaactcacttagtcaggtgatggctca
cctgggcaggaaggcagagagcaggcttctttcccatcctgtttttcatagcattgtagg
ccccactgtcttgcttccattttgaggaggagagacaggcagagagtaagtgttctgtcc
acatgctgaccctggagaaagcaaggcctctaacgcttgctcctaaaaatctgagcggag
cccagggctgtggaagaggcagggcaccctcgctcagtggggttcaggccattggcatga
acgtcactggagtggttctggaagcagggctctggggctctacgggccaaagcatccagc
aagaaactaaggccagggcacagagtgcaccatctggacctgctctgctcaggttcccac
cctgggccaatgacccccgggtcctttttgtgacctttagagctggaatccctgatgctg
cacaccaactatactaggctcaattacagctgaaagccct
>IGR2238a
ggaagcagggctctggggctctacgggccaaagcatccagcaagaaactaaggccagggc
acagagtgcaccatctggacctgctctgctcaggttcccaccctgggccaatgacccccg
ggtcctttttgtgacctttagagctggaatccctgatgctgcacaccaactatactaggc
tcaattacagctgaaagccctgagcttggaggtaagaaactgggttttagctcccactct
actattaactcttccaacctcagataagcatcaccccatgctgtgccttgatttccccat
ttgtaaaacagggattggggtaaggaataggctgcaccgcttgagtttccagcttccaat
gtgtggttccatctatagttaccatgaacagaaaaagaggtctgaagacatggggaagca
gccagacgcttggatctggctacgcctgcctaaacaagagccaaaagcaggaagaaagcc
caaacgggaaacttagtggttcacagaaaaatgaaaaatgtttttcagacagagagatgg
tgctcagtagtaacctttgcagacttctcacatgagcaaccaccctcctaggaactcaga
cccttgcctccctggtgccaggctgctagcctgccctccacggagcctgctggctcctca
ccaacaacgcaggcaaggggacatgcggctccctagaaca
>IGR2239a
ttcacagaaaaatgaaaaatgtttttcagacagagagatggtgctcagtagtaacctttg
cagacttctcacatgagcaaccaccctcctaggaactcagacccttgcctccctggtgcc
aggctgctagcctgccctccacggagcctgctggctcctcaccaacaacgcaggcaaggg
gacatgcggctccctagaacaaagcatctcttccaagccagtgacagggaaaaacaagcc
tgcttctccgcactgctgggcagtgtgggcgcacagcctccgggcacctctcagaggggt
tggcaggcaaccctcaggctggacacggagaactcccgcagcaggcacactgctggtgct
ccgctttggaataagcgtgaacctggatgggctgggagtagggtggcaatccccaaccca
gggaagaactggagcatccaacccctaatcaggaggcagcccagactagcaggagtcaag
aacatgggaggaccacagcctgactgcccaggctgccacagcctccaacctccacagcct
cagaagggccagcacccacaggccatctctctggtaggtgggtaagtatccctgcagtgg
cccccacccacacatggctgctaaatctaggactgggagtggaggcggagaaaaagctga
gggaattgatgacagggtgccggcctctgtgtgtgaggcc
>IGR2240a
ctgactgcccaggctgccacagcctccaacctccacagcctcagaagggccagcacccac
aggccatctctctggtaggtgggtaagtatccctgcagtggcccccacccacacatggct
gctaaatctaggactgggagtggaggcggagaaaaagctgagggaattgatgacagggtg
ccggcctctgtgtgtgaggccaagcttcaggggccaggacctggctcctgccactcttga
gtatgatgggctctatttcccagctagcatgtcttttatagtggaaaagatgaaaacatg
aacaaagggtcagcagcggtttctcacaggactatcatgaggtgagggttggggacccat
atggctgagctagactagcaatccacgtgggcttctgcagtgagttctggggttgtagac
cccaggacaggtctcccaatatcaggcttctaaagactccttggctggcaaggttgggtg
tgacctaaaaccaggtcagacaatctctgcaggggacagggtgactatagtgctcatttt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-156
gagacaggccccagagcatctctcaggctcccttagccccaccctctctacttggtccag
cctgtccttagtctaggcaggtgtgtaactccttggttaactctgccatccacccaccac
tgaccgcccttgacaactctctgggcctggctttgggccc
>IGR2241a
acaatctctgcaggggacagggtgactatagtgctcattttgagacaggccccagagcat
ctctcaggctcccttagccccaccctctctacttggtccagcctgtccttagtctaggca
ggtgtgtaactccttggttaactctgccatccacccaccactgaccgcccttgacaactc
tctgggcctggctttgggccctccaaaagcaaatatgcattaacacttctttcctattgg
ccgcagggggtctgtgagcaggatcaggaaaggtgctaggtctcaaaactgaacacaagg
gcaaacatagattgggtcccagcctgccaatccgtccacatatctgtcaaccaccagatg
gactgcagtaggttccaggacttggccagaatctccctgagaagaggtggatgagaagca
catagagtccaggctaagtaccccctacttaaattgtttacaaaggagtctagcattcct
tagctcctggctccccagctgtgattaaagctgctacagaccagcttattgatgcctccg
cctggcacatgggatgggctatactggctgatgatcacaggtatcaatgttaaaatggaa
tgtgtgggtttaagatttgggtcacgagtctaatgctgtcacccttcagctggctgagct
gtgaatgcaggcccaacctgaaaacaatctgggagcaact
>IGR2242a
tgtgattaaagctgctacagaccagcttattgatgcctccgcctggcacatgggatgggc
tatactggctgatgatcacaggtatcaatgttaaaatggaatgtgtgggtttaagatttg
ggtcacgagtctaatgctgtcacccttcagctggctgagctgtgaatgcaggcccaacct
gaaaacaatctgggagcaactctggcaaagggcctagacttgcccctcttcctggggaga
aatgcacctttctagtggtgatggtttcaagggtgtagagatacatgtgtgccaaattgc
atgctttagctacatgcagtttttatgtcatttacaccttaataaagctattaaacattt
ttaaaaagagggagaattgtgtctcctatacctcatacataattggcactgctttttcag
ttatgagaagtagagagatgacatagttccctgggactaaatgttcttacctgtgaattg
gcaggaagggaaaaaagatagggtgtgtgcccctaagacagaagttcttccctgagggga
tgtacctagcctgaccgtatcaacagtcagacatgctgctaggtaccacatgttactgat
tgccatgtattcctatattcctacacacattttatcctgcctcctgctgaaatcaatgat
gaatccttgccccaccgttgtcagagcaaagagaaaaggt
>IGR2243a
agggtgtgtgcccctaagacagaagttcttccctgaggggatgtacctagcctgaccgta
tcaacagtcagacatgctgctaggtaccacatgttactgattgccatgtattcctatatt
cctacacacattttatcctgcctcctgctgaaatcaatgatgaatccttgccccaccgtt
gtcagagcaaagagaaaaggtatttcctatctttgctatcacatcctctacaactcctgg
cagtgccccctgtatcgaagagaggctcaggagctctttggtacataggtgagtgaatga
atcgataaataaaaaggtatcaaccttcaacatcttggtatactttagttcttgcttggc
tgcccaaagtcgagatgaaccctgaactcctgaacttcaatctccagaatactctttttt
ttcttttgaaacagagtcttgctctgtctcccaggctggagtgcagtggcacaatctcgg
ctcactgcaacctccacctcccgggttcaagtgattctcatgcctcagcctcctgagtgg
ctgggactacagggatgcaccaccagcctggctaatttttgtatttttagtagagacggg
gttttgccatgttgaccaggctggtcttgaactctgacctcaggttatctgcccaccttg
gcctcccaaagccctgggattacaggcaagagccaccaca
>IGR2244a
cccgggttcaagtgattctcatgcctcagcctcctgagtggctgggactacagggatgca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-157-
ccaccagcctggctaatttttgtatttttagtagagacggggttttgccatgttgaccag
gctggtcttgaactctgacctcaggttatctgcccaccttggcctcccaaagccctggga
ttacaggcaagagccaccacacctggccatttttttttttggctccctgaccccctgctt
tgtgtcaactgtcagaaatttgacccaggatgacaggtgtcagctagctagagagtggct
caatctgaccactcatggccagatgtgtctactatgtacgtgcatagtgggccacgggac
cccgcaagtggcttctctgccttgccatatagctgcaaaaggctggatgagggtctgtgt
gtcccctgagtgagagaaatcaacaaaggcgtaacagtgaggttcaagttccaggtctct
cgggtctctgctgcccagagtcagccccggtcccagctcccaggttgctctggcttttcc
tccaggcagctttggggataacagtgagggctctctcatcttctaagactatctgtctct
acacaagataaggctgatagaaaagctagtccaggacaatggggagggagtgggagtccc
acccaggactgggccgagggcttcttagaagcagacaggt
>IGR2245a
gtcagccccggtcccagctcccaggttgctctggcttttcctccaggcagctttggggat
aacagtgagggctctctcatcttctaagactatctgtctctacacaagataaggctgata
gaaaagctagtccaggacaatggggagggagtgggagtcccacccaggactgggccgagg
gcttcttagaagcagacaggtggagagcaaggcgatgcagagcagcttggaagtttcttt
tctttttctttttttttttttgagacggagtcttgctcttgtcacccaggctggcatgca
atggtgcgatcttggctactgcaacccccacttcccaggttcaagaaattctcctgcctc
agcctccctcccgagtagctgggattacaggcacccgccaccacgcagggctaatttttg
tatttttagcggagacgaggtttcaccatgttggccaggctggtctcgaactcctgcctt
gtgatccacctgcctcagcctcccaaagtgctgggtttacaggcatgagccaccacaccc
agccggaagtttctcaaggaacctgtctgtccataggctggacagagctatggtgaaacc
aaagagcggacagcccagacaacctcagaaacaacccaggtttccagcagatggggcagt
ccatggccaagaagcactgcatgatgggttggctaattcc
>IGR2246a
ctcccaaagtgctgggtttacaggcatgagccaccacacccagccggaagtttctcaagg
aacctgtctgtccataggctggacagagctatggtgaaaccaaagagcggacagcccaga
caacctcagaaacaacccaggtttccagcagatggggcagtccatggccaagaagcactg
catgatgggttggctaattccccagtaccccagggatgactgaggggccagaggagaggc
cagccgagaaccatgtggaccaccaaactattcctggaacatgggggcataaaactcttt
tacctcataaatcatttttatttattaatattattattattcttttgagatggagtctcg
ctttgtcgcccaggctagagtgcagaggctcgatctcggttcactgcaaagcccgcctcc
tgggttcaagcgattctcctgcttcagtctcccaagtagctgggaatacaggcatgtgcc
accacacccagctaatttttgtatttttagtagagatggagtttcaccatgttggccaga
ctggtcttgaactcccgacctcaagtgacctgctgccttggcttcccaaagtgctgggat
tacaggcgtgagccaccacgccctgccaatatttatttatttattaattgctagcagatt
ccctctgccaatcccaacacctcattccacatccatgtgg
>IGR2247a
tgtatttttagtagagatggagtttcaccatgttggccagactggtcttgaactcccgac
ctcaagtgacctgctgccttggcttcccaaagtgctgggattacaggcgtgagccaccac
gccctgccaatatttatttaritattaattgctagcagattccctctgccaatcccaaca
cctcattccacatccatgtggcatcaaagccccagtcagtgggcagggggagtcacattt
cctttaaaaaattccagtcaatccttttcagccaccctcaagtttcccttctaagaactg
aactatttttctttagttctcaaactttagagatgatttcttaaattattcattaactca
ttcaataaaaattttcctgagaacctccctctgcatccagaattgtgtcagaaattgagg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-158
aagacgcaaagatctaaatccaccacaaagtttggtactacatgtatgtactttaacttg
aacaaattaaaaaaatccaaacaggacacctgaggttccagtcttcagtggaaaaaatat
gactagtaattcaataccagtgtacttacaaacacctttatgtatgatttggggcagagg
gcaggcttagagacatttagcaggcatgggactagatgcagtgttcagcaggccaggttt
gggttgaaagacaacaggccatagaaaaagccattagaat
>IGR2248 a
aacaggacacctgaggttccagtcttcagtggaaaaaatatgactagtaattcaatacca
gtgtacttacaaacacctttatgtatgatttggggcagagggcaggcttagagacattta
gcaggcatgggactagatgcagtgttcagcaggccaggtttgggttgaaagacaacaggc
catagaaaaagccattagaatgttgatgcagcaacttccagcagtagctgttcacctggg
aacaagcagctctgaacttcaagtcaagcattccagtagcccaaaacaaagatctaagca
ttaatctggcctccctgcaaagactgacaacatataagtaggtgaaagggcacataactc
ctttgaaactgctaagacagctaaataaatagtctaaatattaaaaaacaaaaggctgac
attggcagcaagataaggtcagaccccctggcacagctggcctttgggagctcatcaatg
ccaccatcactcagcccaatgtgggatggaggcagcaaagcaggaacaagtgactagagt
aagccggggaaccctcaggggtcaatgtaaaactccaagagatgccatgtgcttcttctt
gcttcactacttccctcttctttaggcagccccaagtagaatttgtagggattcctgtgt
catgttcccctctgtggcctctgcctgcaacctcagggac
>IGR2249a
tgtgggatggaggcagcaaagcaggaacaagtgactagagtaagccggggaaccctcagg
ggtcaatgtaaaactccaagagatgccatgtgcttcttcttgcttcactacttccctctt
ctttaggcagccccaagtagaatttgtagggattcctgtgtcatgttcccctctgtggcc
tctgcctgcaacctcagggacagcctctgctttcatagtactcactggcttccgggaagg
taacacacccacctgtgaggctaggacccaggatttgtggcaactgaaagttccaatttc
ctgtggattcatgggccagaaagcacagttggctacctccaaggagtgcctcttttgtca
agccatgatgcctctggacactgaagctatgtcactagctaagaaatcccagtggggctc
cggtcacactcccactacatatatgtggagaaagcaggtccaaatgctggggacatcaaa
tttccaaaaagaaaaaacacacacatgcacacacacttggatctcccagggtagctctca
gactccattgaagggtgatgacgccaagaagcaacacagttgggatctccagagcccctg
taagcccctctgaggctccaggaggggaggctcagcaccaacatccagcagggcttgaag
ctgtgccagggcctgtggcactctccctctctatgaactc
>IGR2250a
cacacatgcacacacacttggatctcccagggtagctctcagactccattgaagggtgat
gacgccaagaagcaacacagttgggatctccagagcccctgtaagcccctctgaggctcc
aggaggggaggctcagcaccaacatccagcagggcttgaagctgtgccagggcctgtggc
actctccctctctatgaactctcccctctctgtgaactccgccgtcctgctgggtggttt
cttgctgctgcattggggccttcagctcactattatgctgagctgaacaccctaggctca
ctgagaggcctcctcttctgggaagccttctctaacctgcgaattggtcatctgcacatt
tagtgagcctatctatcaatgagggctactcactggctacttactcaatgctgctgaaac
ttcagggagctagagtgccagtgtctaaaaaagacacaaaacacatacatcattaacatc
atgttcctacatccagctccaacaactgctccaacaggttcggaggggacagacaaaacc
acccagagggaaaatccaaggggatgagaaatgagaaaggctcccccacaccctatgacc
taaggctgtatgctttaactaaatctggccgacagccttgcctcataatacctgagaaaa
tattccaggtcaacaagtcaccctgaacccatcttcagat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-159
>IGR2251a
caacaactgctccaacaggttcggaggggacagacaaaaccacccagagggaaaatccaa
ggggatgagaaatgagaaaggctcccccacaccctatgacctaaggctgtatgctttaac
taaatctggccgacagccttgcctcataatacctgagaaaatattccaggtcaacaagtc
accctgaacccatcttcagatgaatggatcttaaagagtgacaactgacggcctggcgtg
gtggctcacggttgtaatcccagctttgcaggcagaagcaggcagatcacgaggtcaaga
gatcgagaccatcctggccaacacggtgaaaccccgtctctactaaaaacacaaaaatta
gctgggcgtcgtggctcacagctactcggaggctgaggcaggagaatcacttgagcccgg
aaggcgaagattgcagtgagccaagaacgcacgactgcgaaggttgcagtgagccaagaa
cacacgactgcgctccagcctggtgacagagggagactctgtctcaaaaaaaaaaaaaaa
aaaaaaagactgacaactgaccatgggaaaaggcaaacaattacttacagggcatgacca
gattgtcgtttttgggttgtggacggtaggggaaggagtaactagaggaaaaagggaaga
ggcagttgtatacacatgctttatttaacttttaaaagtt
>IGR2252a
ctggtgacagagggagactctgtctcaaaaaaaaaaaaaaaaaaaaaagactgacaactg
accatgggaaaaggcaaacaattacttacagggcatgaccagattgtcgtttttgggttg
tggacggtaggggaaggagtaactagaggaaaaagggaagaggcagttgtatacacatgc
tttatttaacttttaaaagttcaggaaagagaagtatttcttctcttctaaaaagaaatc
aagagactagaggaaaaacgggatagcccctggcccaagtcctggctctgctacttacca
cccccaaccccaactagagtaagtcctggacacacagggccatagagcatcgcccaggga
ccgccaggaccttcctggtaccctcttcaaagtggccatcaggacgggaggccagactga
ccacctgtgcagggaggagcacactgtggctggaggtcacctcgtgaagcgttcccaagc
cacctggctggagggtctccatcgctagggtgttgaccgttgggggagggggagtgacag
cgtccagtgcgcatctgggagagaggagctcgggttcaaggaccgcgacaggtcctccga
gccctggtctcagccccagcaggggccggcacccacctcggtcacaatggtggacaggta
gacgtcctgactgaactcccagccatccagacagctctcc
>IGR2253a
catcgctagggtgttgaccgttgggggagggggagtgacagcgtccagtgcgcatctggg
agagaggagctcgggttcaaggaccgcgacaggtcctccgagccctggtctcagccccag
caggggccggcacccacctcggtcacaatggtggacaggtagacgtcctgactgaactcc
cagccatccagacagctctcctgctccagctgccccaggtccacgtcgcgccccggctcc
agcccgagcgccgagaagttggcgatggtggcgagccggtagcggcggcagctgtggggc
acctcgcggccgtcccgcagccgcagtgggacagtgtggttgcgccaggcgctgctcagg
ttcgcggcgtccggcacccggcagcggtgctccggggtcgctatcaggaacacggaggac
aggccggtgaagccattggggatgatgctggcgctgagcaggaagaagatgaggcgctgg
aagggcccccactcgcccaggaaggcggtcacctcgtcgtagtcccgcatgccgccctca
gaggcccacagagcgcggcctggggtctgggaacgcggcgggctttgcgcgtgcgcgcgg
ggcacccgccgccgaccaggcaagccaggcagcaggcgacccaagaccgtccgcggaggg
taggctcgcgagctgacaccgccgccttggtcctgccgcg
>IGR2254a
ggaaggcggtcacctcgtcgtagtcccgcatgccgccctcagaggcccacagagcgcggc
ctggggtctgggaacgcggcgggctttgcgcgtgcgcgcggggcacccgccgccgaccag
gcaagccaggcagcaggcgacccaagaccgtccgcggagggtaggctcgcgagctgacac
cgccgccttggtcctgccgcggctggccttacatatggcgcacgaccagggaaggttccg
ggcctgggccgcaaggcgcgccccgctggcaggcagagcggcgccggcgaaggcggagct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-160
ggggcgggacgcgagggcgcggggcgggccgggagtgcacctgaggcccgggcggggcct
gtcctggggacctggcgaggcccggcctctgccagccacgcctgctggggacgaccgagg
tagcccggggtcggcttaggaaggcagcgggactcgaggccttggggtccgagtccgaac
tcgctcctctagcgccgggcggggagcgagtgggagagcggccgcgaagctccagtgttg
aaaacgcacccctcccagctttttgcaaggcctacttgggggcggaggtaaggagaaagt
cactggcccagggtctcacagatagttgctcttgacaccgcctaatcttataagagggac
ggggattattttgaacctgggactgttaactaccctagta
>IGR2255a
cggggagcgagtgggagagcggccgcgaagctccagtgttgaaaacgcacccctcccagc
tttttgcaaggcctacttgggggcggaggtaaggagaaagtcactggcccagggtctcac
agatagttgctcttgacaccgcctaatcttataagagggacggggattattttgaacctg
ggactgttaactaccctagtagagaggctgggagctatgacttttcattctagtccagat
gccctttccacattttcgtctgtaacaagccattttgttcatgcagatgtaaaaatttaa
cttcacgattaacgatcctagcctagggttaaatattccccacagattagttatttccgt
gcagagtttattcagaagctaactggaaaaaaaaaaaaagcagcgaggtgattctaaagc
agcaatgttccataggataaggagctacatttgttatgttaacttttctagtagccatat
taataaaattgccagatttagcaaataaaaatataggactcctagttaaatttgaatttc
agatatagaatgaataatttttaaatattatgtcccaagcaggaatatataaaataaaaa
tgtaactggttgtcctgtattttattgggcaatgctgcatatttaaaaagtaaaaataaa
agatgaaattaactttagtggtatatttaatcaagtatat
>IGR2256a
agcaaataaaaatataggactcctagttaaatttgaatttcagatatagaatgaataatt
tttaaatattatgtcccaagcaggaatatataaaataaaaatgtaactggttgtcctgta
ttttattgggcaatgctgcatatttaaaaagtaaaaataaaagatgaaattaactttagt
ggtatatttaatcaagtatatccagaacatgatcatttcatcatataatcaatatagaaa
ttattgatattttacattgttatatgtaaatcattgatctttttttcccctcctcatact
aaatcttaagaattcagtgtgtttcacaggttctcaggatttgaaaaaaaaaaaaaaagg
aatccagtgtgtattttacagcacatttcaatttggactagccacactttttatttttta
atatttatttattcatttatttattggagacacggtcccactgtgtcacccaggctagag
tgcagtggcacaatcatagctcaccgcagccctgaactcctaagcttaagtgggcctcct
gcctcagcctgctgagtagctaggactacaggcacatgccaccgtgcccagctaattttt
ttattttttttattttacagagacaaggcatccctgtgttgcccaggctggtctcagact
cctgggtttaagcaatcctcccacctcagcctcccaaaat
>IGR2257a
ctcaccgcagccctgaactcctaagcttaagtgggcctcctgcctcagcctgctgagtag
ctaggactacaggcacatgccaccgtgcccagctaatttttttattttttttattttaca
gagacaaggcatccctgtgttgcccaggctggtctcagactcctgggtttaagcaatcct
cccacctcagcctcccaaaatgctgaattacagacgtgagccactatgcctggccagact
cattttttaagtgctcagtagccacatgtagctattggttatcttattggacagcaccat
tcctaaggcctttaagaatttgggctgctaaacttaacaatgcaagatattcctttttaa
aatagtagtggcttagtgatagaaacagaactaagtgtatatttttacaatataatgtgt
tgggtaaagaatatttaatagtcactatattatgagttgaaaataaagctacagaaaggg
aacctaacctggccagcagatttttaataaggaaatctaaacatttgcataaagcataat
agacttaaaaaaattatgataaagatgttatcacaggacttgtttgtttctttatactta
ctattcactattcttacttcgtgaagatggatggttataccttcagcaatgtacttaaat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-161
ccttctaacatcttatgtgaagttatagttcttatctaga
>IGR2258a
atttttaataaggaaatctaaacatttgcataaagcataatagacttaaaaaaattatga
taaagatgttatcacaggacttgtttgtttctttatacttactattcactattcttactt
cgtgaagatggatggttataccttcagcaatgtacttaaatccttctaacatcttatgtg
aagttatagttcttatctagaactaactgaaaaagaaagcaaagcttcttgaaaataaac
tccttttttgtgtgctaaaatattattttaatgcttcaaaagaaatgaaagcttttatga
gaagaatgttgacctctgtccagaccaaacaagatgaagaagtcttattttaacatttga
gaaatatcagttgggcatcagataacattcctgaaagggactgaaaacaatgcagtatac
tacaaaagaagctgcatatccttaggaagaaaagaaactatttgtcatagatggcttgtc
cacatgcgcaaagcagagagcaacctaagatggtgccgtccagttccaggtgcactgtga
ttactatctgaatgccattactatttaaattgcattttttttttgagacagggtctcctt
ctgtcacccaggctggagtgcagtgaggtggtcttggctcactgcagcctcaacctcctg
ggctcaagcaatcctcccacctgagccttccaagtgcctg
>IGR2259a
gcaacctaagatggtgccgtccagttccaggtgcactgtgattactatctgaatgccatt
actatttaaattgcattttttttttgagacagggtctccttctgtcacccaggctggagt
gcagtgaggtggtcttggctcactgcagcctcaacctcctgggctcaagcaatcctccca
cctgagccttccaagtgcctgggactacagccacgcgccgctacacccagctattttttt
tgtatttttggtagagacagggttttgccattttggccaagctggtctcaaattcctgac
ctcaagtgatccccccgtcttggcctcccaaagtactgggattataggtaggagccacca
tacccagccttaaatttcatcttttaaaagagaaagagagcttagaatcttaatcagtta
cctgaggccctttatcctgcaatattctgaattgggatgttcctattttacatattaaaa
aatgtaaaactgatttatatggtagataaccctacagttcagggctagaactttagatta
aatgcattcataccctggcagatgtggtagcttgcctccaagatggcacccaatgaatga
tccctgtaccaggattggtctatgtgaccaaaagcatacagcattagtgatgatacttat
atcacttgggtaattacattataaaagatgtccatcatgg
>IGR2260a
tggtagataaccctacagttcagggctagaactttagattaaatgcattcataccctggc
agatgtggtagcttgcctccaagatggcacccaatgaatgatccctgtaccaggattggt
ctatgtgaccaaaagcatacagcattagtgatgatacttatatcacttgggtaattacat
tataaaagatgtccatcatgggtgttcttttccctttctcttgctcagagacaagcaagc
tgtcatgttataagcagccctttgaggggtccatgtgatgtcaaggaatgaagtctctag
ccaacatttaatgaggaactgaggcccaccaacaaccttgagtgagcttggaagtagctc
cttcagcatcagttgggtgtcgagatgactactgacagcttgactgcaacttcatgagag
tcttctggaccagaaccactcagttaagtggctcccagattcctgatcctcagaaactct
gagaaataatgaatgttggttgttttaaaatggtaaattttgaggtattatgttatgtgg
caatagatagctaatatataaattatttgaatcaaacaatacgttaaattaaagctcaga
agaataaacatctgtaattccttaatttgttttcccttctattctacagaatagaatttt
acagatgaaccttgtagttacttgtgcaataagagacagt
>IGR2261a
ttgttttaaaatggtaaattttgaggtattatgttatgtggcaatagatagctaatatat
aaattatttgaatcaaacaatacgttaaattaaagctcagaagaataaacatctgtaatt
ccttaatttgttttcccttctattctacagaatagaattttacagatgaaccttgtagtt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-162-
acttgtgcaataagagacagtatgttgtattgattaagtgcagagcctctggatgtatga
tagaagaaagaccaatattcaattgctttcttcttcaattccaagcttgtgagcttgagc
aaattttaaaagtgttttaagcctcagtttcctgggatggtagtgcttagctcgagctcc
tagcatatattaactacaaactaaatattagctataattattagttttactttgattatt
gactctaaataaataccttaagaactttgtgttctccacagatttggatatgtctggacg
ttatgtaggctggagtagtcagcaattacttgcctgaggaagggaaggcctcctccttta
agaaaagaataggctgggtgcggtggctcatacttgtaatcccagcattttgggaggctg
aggagggtggatcacctgaggtcaggagtttgagaccagcctaaggaacatggtgaaacc
ctgtctctactaaaaatacaaaaattagccaattgtggca
>IGR2262a
cagcaattacttgcctgaggaagggaaggcctcctcctttaagaaaagaataggctgggt
gcggtggctcatacttgtaatcccagcattttgggaggctgaggagggtggatcacctga
ggtcaggagtttgagaccagcctaaggaacatggtgaaaccctgtctctactaaaaatac
aaaaattagccaattgtggcacgcgcctgtagtcccggctactcaggaggctgaggtgag
aggattgcctgagcctgggaggtggaggttgcagtgagccgagatcgcgccactgcactc
cagcctgggcaacagagtaagactccgtctcaaaaaaaaaaaaaagaaagaaagaaaaga
gtagaaggcccaagcttagtccaatattatagcttcagcatcagagtagagaatgattca
gagcatctgtccagtgtctgctgtagatccctcaaatccgtgtttggacgcttctggtaa
ggggtgtatggcagatgcacccgacagatgcacttggcagcaataacttatgcatacctg
aagaatgaccctatggtctaagaagaatgtgtgttcagagctccaagctaaggaatctgg
gagtggccaacccagatatttcatttcttatctatgacgaacttctgaactgctcccacc
cccagcccatcctgtagaatgcaggccctacgaggcgatc
>IGR2263a
cccgacagatgcacttggcagcaataacttatgcatacctgaagaatgaccctatggtct
aagaagaatgtgtgttcagagctccaagctaaggaatctgggagtggccaacccagatat
ttcatttcttatctatgacgaacttctgaactgctcccacccccagcccatcctgtagaa
tgcaggccctacgaggcgatcaaagccctttgttttaggttaaatgaaggttgcctggtg
gaggttgctaggggaaaggtgttaagtaaaaatgttatataaactgcatggtgttttttg
tttgtttttgtttttttgagacagagtttttgctcttgttgcccaggctggagtgcaatg
gtgcaatctcggctcactgcaacctccgcctcctgggttcaagtgattctgctgtctcag
cctcccaagtagctgggattacaggtgcccaccaccaggcccggctaattttttgtattt
agtagagtcagggtttccccatgttggtcagcctggtctcaaactcctgacttcaggtga
tccacctgcctcagcctcccaaagcgctgggattacaggtatgagccaccacgcctggcc
aattgcatgctttttacaaggagttttggttctcctgcccagcccactgccactggactg
ccctgtattgtaagtcccctcaataaaccttatgtctcag
>IGR2264a
catgttggtcagcctggtctcaaactcctgacttcaggtgatccacctgcctcagcctcc
caaagcgctgggattacaggtatgagccaccacgcctggccaattgcatgctttttacaa
ggagttttggttctcctgcccagcccactgccactggactgccctgtattgtaagtcccc
tcaataaaccttatgtctcagtttctggttctaggtctcttcttcagcctcttgaacatg
gtgccatccctactgaagtcaatggggtctgacatgactaggggaacttgaacaaaatct
gaaatagctgtttttttgttgccaaaatcactgtaagacattatttgcctcagccccaga
acattgaattatatgacccaagagtggagaaacagagaagtctgtctgtgtcatcagaca
atatcccaagtgggatgtcatcaccccaatgcatattggcatttgggcagagtagagcag
cgtcagcctagcaagacttggcacaattctgttggattgcacaatagaatgagaaatcac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-163-
atttctgctgttatgtgattctgcattttaactccagtttgtttggcctggacagacagg
taactagccatgaagacaatggaccttgaaacattctgaagactagaaaaagtatgtaat
aaaatactttgaacaactgtttaaggacttaaatgtccag
>IGR2265a
ggcacaattctgttggattgcacaatagaatgagaaatcacatttctgctgttatgtgat
tctgcattttaactccagtttgtttggcctggacagacaggtaactagccatgaagacaa
tggaccttgaaacattctgaagactagaaaaagtatgtaataaaatactttgaacaactg
tttaaggacttaaatgtccagactgtttctttagatgagtgtaatttccaatgtgaaacc
ccacaattcggcttcaagaggtacaggacagtttttgaattccacagaaaaaattttgca
ttgcaacaaacttgaccatcctatttgtggtagtagaaatgtaaattcattcccctcaga
gatacctgcaaaaatgaaatgtgaaatattctgcttgcattttaaagactggttattgca
ttctagaatagatggaaaagacattagtgagggccaatatagaaatatgagttttcccaa
aagacttttatgtatatatatgacatggcaggaaaattgggtcactagtggtttttactt
cttcgttcatttggcaaacatatgaatagactgatgtgtgccaaacactgttccgagttc
tgggaactgaggaaagaaacaagctatctgttttcatggagctcgtattttacttggagg
atggagaggctgacaataaacttgtacaaataaatacaaa
>IGR2266a
atgacatggcaggaaaattgggtcactagtggtrittacttcttcgttcatttggcaaac
atatgaatagactgatgtgtgccaaacactgttccgagttctgggaactgaggaaagaaa
caagctatctgttttcatggagctcgtattttacttggaggatggagaggctgacaataa
acttgtacaaataaatacaaacttcaagtagtggtaattgccaaggtgaaagaaaagaga
gtaatggtatagaatgacagtcattgggtagctgctttagatgaatggtaagtgaacatg
tttctgagaaagtgatatctgagctgagaggcaaaggacgagaaggaatctgtcatgtga
agatctgggaagcaggtgtactaagcagaagagcagcaagtacaaagactgtgaggtaag
ggatgtgctcggggtgactaagtaacggagagaagaccagcgtgactagaacatagtgat
caaagtgagtaatgttggaacataagtcagagacattggcaggaggccagtttttatgga
agccaaattgtctagtgccttgtagatagtggcaaggagtttggattttattctagatgg
aacactaccagaatattttttcttttttgagacagggtctcactgtcacccaggctggag
tgcagtggcatgatcttgactctctgcaacttctgcctcc
>IGR2267a
acataagtcagagacattggcaggaggccagtttttatggaagccaaattgtctagtgcc
ttgtagatagtggcaaggagtttggattttattctagatggaacactaccagaatatttt
ttcttttttgagacagggtctcactgtcacccaggctggagtgcagtggcatgatcttga
ctctctgcaacttctgcctcctgggcttaagtgatcctcacacctcatcttccccagaag
ctaggactacacgcaccacacctggctaatttttgtattttttgtagagatgggattttg
ccatgttgcccaggctggtcttgaatgctgcccactttggcctcccaaagtgctaggatt
ataggtgtgggccaccgtgcctggcctatcagagtattttcaggcagagaaaagcataag
gtcttacttctagcataaaaggaacattctggctgctatatagagaagggactgtagagg
acaagaatgaaagcaggttgactgattagaaagcattgcagcattataggcaagagctta
tgatggcctgaactagagtggtaactgtggaagagataaatggatgaattcagaatattt
ttggaggaaaaaggtgacatgatttactattggatgtgggcatgagggaaggaaattaag
gatgactcctggatttttagcctgagcaactttatagctt
>IGR2268a
gactgattagaaagcattgcagcattataggcaagagcttatgatggcctgaactagagt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-164
ggtaactgtggaagagataaatggatgaattcagaatatttttggaggaaaaaggtgaca
tgatttactattggatgtgggcatgagggaaggaaattaaggatgactcctggattttta
gcctgagcaactttatagcttttcatgtttgtttttgaaatggggagatttgatggggtg
ggggtttgggaaattaagagttttttatttttattttttgctttttaaaaattgtggtga
aatacacataacataaaatttaccattttaaccactcttaagggcattaagtacattcac
attgtgcaaccatcaccatcatccatctgtagagaactcttttcatcttgcaaaattgaa
actctgtacctattaaacactaactccccactcccctccttaccctagccccgaaaaccc
ttctataatacagaagtctctatgaatttgaccactctcataagtggaatcacatagtat
ttgtccttttgtgactcgcttttattgtcacttagcataatgtcttcaaggttcatccat
gttgtagcatatgtcagaatttccttcctttttaagactgaataatatgccattatatat
gtatactacattttgtttacccattcatccactgatggac
>IGR2269a
ctatgaatttgaccactctcataagtggaatcacatagtatttgtccttttgtgactcgc
ttttattgtcacttagcataatgtcttcaaggttcatccatgttgtagcatatgtcagaa
tttccttcctttttaagactgaataatatgccattatatatgtatactacattttgttta
cccattcatccactgatggacacttgggttgcttccatcttttgcctgttgtgactaatg
ctgctgtgaacatgtatgtacaagtatctatttgagtacttgcttttaattctttgggta
tatacccagaagtggaattgctggatcatgtggtaattctatgtttaatttttttaagga
attgccatactgttttccccggtagctgtaccattttacattcccaccaacagtgcacaa
gagttccagtttctccacgtcctcgccaatacttgttattttctgtggttttgctgttgt
tgttgttttgtttgtttttgtttttttacagaagctatcctaatgggtataaagtggtat
ttcattgtggttttatttgcatttccctaattattaattatgttgagcatcttttcatgt
gcttattggcaatttatatattttctttggagaaatgtctactcaactcttttgcccatt
ttaaaatcaggttttttttttgttgttgttgaattgtagg
>IGR2270a
gtttttttacagaagctatcctaatgggtataaagtggtatttcattgtggttttatttg
catttccctaattattaattatgttgagcatcttttcatgtgcttattggcaatttatat
attttctttggagaaatgtctactcaactcttttgcccattttaaaatcaggtttttttt
ttgttgttgttgaattgtaggagttctttacatatttgggatatgaaccacttatcagat
acatgatttgcaaatattttctcccattctatgccttttcactattgattatatcctttt
acgcacagaagttttacatttttgatgtagcccaatttttctattttttcttttgttgcc
tgtgcaagagttttattttaaatgcaattttgggatgtctattagacatccaagtcaaaa
tgtcaaatagacggctggatatatgagtctgaaggtcataaaagagatcagaatgagata
taaattagggaatcattcacatatagatggtatttaaggccatgggtctggacagaatca
cccaggagagaagtcatataggaacacataggtttccctagggaatacagtcatcttaga
gtaaaattccatcgaaggagatcaggaggtcttggctgagttaaatttggataatataag
ttattaactatgttaatgtgttctaagctagatgccaggt
>IGR2271 a
catatagatggtatttaaggccatgggtctggacagaatcacccaggagagaagtcatat
aggaacacataggtttccctagggaatacagtcatcttagagtaaaattccatcgaagga
gatcaggaggtcttggctgagttaaatttggataatataagttattaactatgttaatgt
gttctaagctagatgccaggttaaggcagaaattaggaggtcctgggcaagtatcaattt
gctctgctattgtattattacaagaataatactaacaatagtacatgacctcatttcatc
ctcacaatagctttacgcgattgatattcttgtcttcactttacaggcaaagaaacaaaa
gagaagtaaagtaatttacccagttgctatagttagcatgtggtaggtccatattagagg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-165
tctggtctgtctgcatgatggttaattttatgagatagcaagtaaaacattatttgtgtc
tgtgtctgtgtctgtgaggatgtgttcggagaggttcacaagcatttgaatcagtagacg
gagcaaataaggtccgccctcaccaatgtgggcaggcatcatccaattcactgaggactc
ctgctcacacagaacaaaaagtcagaggatgtgcctatagttccagcttcttggaaggct
gcggcaggaagatgctggggcccaggagtttgaggccagc
>IGR2272a
atgtgttcggagaggttcacaagcatttgaatcagtagacggagcaaataaggtccgccc
tcaccaatgtgggcaggcatcatccaattcactgaggactcctgctcacacagaacaaaa ,
agtcagaggatgtgcctatagttccagcttcttggaaggctgcggcaggaagatgctggg
gcccaggagtttgaggccagccagggcaacatagtaagacctttctctttaaaaaaattt
tttttggctgggtgcagtggctcatgcctgtaatcccagcactttgggaggccgaggcag
gcggatcatgaggtcaggagatcgagaccatcctggctaacatggtgaaaccccgtctct
accaaaaatacaaaaaattagccgggcgttgtggtgggcacctgtagtacccgctactca
ggaggctgaggcaggagaatggagtgaaccccggaggcggaggttgcaatgagtggagat
tgcaccactgcactccagcctgggcgacagatcaagactccgtctcaaaaaaaaaaaaat
ttttttttaaggcataggaagggcaaattctctcattctctctcttcttgagctgggaca
tccattttctcctgccttcaggaaatcagagctccatgttcttggatctcccgactctgg
gacttacaccttacccttttcccctcagtctttcagactt
>IGR2273a
ctgggcgacagatcaagactccgtctcaaaaaaaaaaaaatttttttttaaggcatagga
agggcaaattctctcattctctctcttcttgagctgggacatccattttctcctgccttc
aggaaatcagagctccatgttcttggatctcccgactctgggacttacaccttacccttt
tcccctcagtctttcagacttggactgaattacaccatcacctttcctggttctccagct
tgcagatagcatgtcatgggacttcttagcctctgtaatcatatgagccagttcatatag
taaatctcctcctattgatctatacctatatctgtaatcctattagttgggtttctttgg
aaaactctaatacccccttatccacagtttttttttttttctgcagtttcagttatctac
ggccaactgggtaaaccaaataggtgagtacagtacaataaaatattttgagagagagat
gcacatttgcatgacttctattacagcatattgttataatcattctattttattagctat
tgttagtctcttattctgcataatttataaattaaattttatcttaggtacgtatgtatg
tatgtataggaaaaaacctagtatatatagtgttcagtactatctgaggtttcaggaatc
ccctggtgttcttggattgtagccccctgccttcaagcct
>IGR2274a
attacagcatattgttataatcattctattttattagctattgttagtctcttattctgc
ataatttataaattaaattttatcttaggtacgtatgtatgtatgtataggaaaaaacct
agtatatatagtgttcagtactatctgaggtttcaggaatcccctggtgttcttggattg
tagccccctgccttcaagcctgcactctcaattactgatgctacatctcattaccctgaa
agatgaaatctagccttgagcccttaccaactggctgcattagatcattttagatctcca
tgtcaccgcagtcacatttgtgtgtggtgaatggtccaggagagatggtgctattcctgc
caccttcattagcctggcttgcattctcttctgaacacttgggtcttattaacactgtgc
caggttctcatataccccaaataaagaaaaagaaagtagatggatacagtgtacatacta
ggcccaacagaagttatgcttttactccctttcctcttcaatttagatactactatggcc
ctttgcttccgtctatctcagttccttcgttgtcttatcattccattcacctctactgca
aggccctaaatccaaccatttggtcactgtactcctaccctgggtcactggaggaaatca
cacaaccatgtgagttggtgtcttgacacatttacatttc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-166
>IGR2275 a
ttttactccctttcctcttcaatttagatactactatggccctttgcttccgtctatctc
agttccttcgttgtcttatcattccattcacctctactgcaaggccctaaatccaaccat
ttggtcactgtactcctaccctgggtcactggaggaaatcacacaaccatgtgagttggt
gtcttgacacatttacatttccaatcacaattggaccctcagcccacttgttactctctc
aacccatgtttccttgcacccatcaacagccccccttctttcttgtatcttaagtcagca
tcctggattgagagtgaagagtaaaatggtttgacttattgtgagcttagcctttgcaag
actagtaaacaaaaggactggggtagtggcaagagtatgaatgggctggagggatcacaa
ggtataaactgaaagggaaaggaaatgatatcaggtgagagctgaagagttgggaggaaa
acaaaggtcctagagtgagatggagctgttgtgactgatgagaggcccagggtgtgtcct
cagcagcaagagtgtgaagtataggtgaaggtcaagtactgcgaggctaaggtgtagcac
tactcatcttcctgagcacaaaagtcaccagcaccttgggctgggtgtcagagagctcac
agaatgtggataaccaaccaggcagatgttggtaacagca
>IGR2276a
atggagctgttgtgactgatgagaggcccagggtgtgtcctcagcagcaagagtgtgaag
tataggtgaaggtcaagtactgcgaggctaaggtgtagcactactcatcttcctgagcac
aaaagtcaccagcaccttgggctgggtgtcagagagctcacagaatgtggataaccaacc
aggcagatgttggtaacagcaaccaggagggcacagcacaaacctgagcaggtcttttat
gtatgtgaaggtgaaggagttatgatttagaaatggcagtgggaagcaaggagaatgctg
agagcctgctcagctcttgtcttccaggatcatggatagtgcaaaatgagtagccttcct
ttgagagacagagccatgaggctagtggagtgctcagaaagaagccagatctctatcaag
gaaaggagatggagagaacaaccagggatgtacttgaaagaggagagttgcatgtctaca
atggaatatgtgttgcagaggactcagtcacagagaagacaactgcaggagggtgagctg
gagggctctgcaggggcaggagcacagtagggcattagaatgggagttttagatgagaag
gattacatttgcagtgctggaggaagatcatctcaaggttcacaaaatcaagctttaaac
ttgtctgtgtcaacagacggaggcattgggtgatagttca
>IGR2277a
ggactcagtcacagagaagacaactgcaggagggtgagctggagggctctgcaggggcag
gagcacagtagggcattagaatgggagttttagatgagaaggattacatttgcagtgctg
gaggaagatcatctcaaggttcacaaaatcaagctttaaacttgtctgtgtcaacagacg
gaggcattgggtgatagttcaaatccccataattttttataatcctttcagcagtctgtt
aaatataaccttggtgataagctaagttacctcagcatagcaagcttggcttggtctaaa
tcagggtagaggtgattgctgctcaaaggaagtgagagagacacccagctctggattgga
gaacatgactttgacctgggtttcagcctccacagggctaagccccaggggagcactggg
caagttgctaaggccacaagcaggagtttataaccaggctagactaagcccactgatgca
agaattttttttttttttttttgagacagagtctcactctgtcacccgggctagagtgca
gtggtgtgatcttggctcactgcaacctccgcttccctggttcaagtgattctcctgcct
cagcctctcaagtagctgggattacaggcacccgctaccatgcctggctaaattttgtat
ttttttagtagagacagggtttcaccgtgttggccaggat
>IGR2278a
tttgagacagagtctcactctgtcacccgggctagagtgcagtggtgtgatcttggctca
ctgcaacctccgcttccctggttcaagtgattctcctgcctcagcctctcaagtagctgg
gattacaggcacccgctaccatgcctggctaaattttgtatttttttagtagagacaggg
tttcaccgtgttggccaggatggtcttgagctcctgacctcaagtgatccacctgccttg
gcctcccaaagggctgggattactggcttgagccaccatgcccagcctgatgcatgaatt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-167
tgcattcttcatgctcttcatctatgcttctgaagacctggcacttagtcaacactcagt
aagtttttattttttaactgctttatgattataaaagtaatatatgaagcatttgtaaag
tatggaaatctggaaaaaataaaacagaagtcatctataatctgaccatccaaacatacc
tactgttaataccttagtctacgttctttctttttttcctttttttgagatggagtcttg
ctgtgttgcccaggctggagtacaatggcatgatttcggctcactgcaacctctgcctcc
caggttcaagcagttctcctgcctcagcctcccaagtagctgggcttacaggcatccacc
accatgccctggtaatttttgtatttttagtagagatggg
>IGR2279a
tacgttctttctttttttcctttttttgagatggagtcttgctgtgttgcccaggctgga
gtacaatggcatgatttcggctcactgcaacctctgcctcccaggttcaagcagttctcc
tgcctcagcctcccaagtagctgggcttacaggcatccaccaccatgccctggtaatttt
tgtatttttagtagagatggggtttcgccatgttggccaggctggtctcaaactcctgac
ctcatgtgatctgcccgcctcagccttccaaagtgctaggattacaggtgtgagccaatg
cgcctggcctttttttttttttaagacagttttgctctttttgcccaggctgtagtgcag
tggtgtgatcttggctcactgcaaccaggttcaagtgattttcctgcctcagccttctga
gtagctgggactacagacgccaccatgcccagctaatttttttgtatttttagtagagat
gggggtttcaccatattggccaggttggtctccaactcctgactttgggtgatccgccca
cgttggcctcccaaagtgttgggattacaggcatgaaccactgtgcccagctgagcctac
tttcttctggtctttttctcatgcctccccaccaccaccccagccccccgccattacata
cgtatatatgtttattttttttttaaagagatgaagtctt
>IGR2280a
ccaggttggtctccaactcctgactttgggtgatccgcccacgttggcctcccaaagtgt
tgggattacaggcatgaaccactgtgcccagctgagcctactttcttctggtctttttct
catgcctccccaccaccaccccagccccccgccattacatacgtatatatgtttattttt
tttttaaagagatgaagtcttgctctgttgcccaggctggtaggctgatctcaaactcct
ggcttcaggtgatcctcctgtgttggcctcccaaagtgctgttgttacaggcataagcca
tcacacctggctatttttcacgctttaaaaactcactttattcattcatttattcactca
ttctttgattaacactcatatactggttttattttattattttatatttttagctacagg
gtctcactctgtgcccgaggctggagtgcagtggcatgatcatgactctgcaaccccgaa
ctcctgggctcaagggatcctcccaactcagcctcccaagaagttaggattacaggcaca
tgctaccacaccctgctaatttttttaaattaatttttttcttccttttttttttttttt
tttttttgtagaaccagtgtgtgttaggccattcttgcattactataaagaaatacctga
gactgggtaatttattaagaaaagaggtttaattgactca
>IGR22 81 a
ctcccaactcagcctcccaagaagttaggattacaggcacatgctaccacaccctgctaa
tttttttaaattaatttttttcttccttttttttttttttttttttttgtagaaccagtg
tgtgttaggccattcttgcattactataaagaaatacctgagactgggtaatttattaag
aaaagaggtttaattgactcacgatttcacaggctgtataggaagtgtggcactaggcat
ctgctcagcttctagggaggcctcagggagcttttactcacagtggaaggtgaaggggga
gcaggtgtgtcacatggtaaagacaggagcaaggtggggggaggtgccacacccttaaac
aaccagatttctcaagaactcacttattatggtggggacagctccaagccatgagggatc
tgcccccatgaccaaaacacctcccagcaggccccacctccaacattagagattacattt
ccacatgcgatttggacagggataaatatccagactatgtcattttgcccctggccctcc
taaatctcatgtccttctcaagttgcaaaatacaatcatgccttcccaagagttccccaa
agtcttaactcattccaatgttaactccaaagcccaaaattcaaagtctcatctgagaca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-168
aggcaagtctcttccacctatgagcctataaaatcaaaaa
>IGR22 82 a
ggataaatatccagactatgtcattttgcccctggccctcctaaatctcatgtccttctc
aagttgcaaaatacaatcatgccttcccaagagttccccaaagtcttaactcattccaat
gttaactccaaagcccaaaattcaaagtctcatctgagacaaggcaagtctcttccacct
atgagcctataaaatcaaaaacaagctatatacttccaagttacaatgggtgtataggca
ttgggtaaacatgcccattccaaaagagaaattggccaaaagaaaggggctacaagctcc
atgcaaattcaaaacccagcagggcaattattaaattgtaaagctccaaagtaatcttct
ttgactccgtgtcccatatccagggctcactggtgcaagaagtgggctcgcaaggccttg
ggaagcttcgcccctgtagtttgcatagtacagcctccacagctgctcttatgggctaga
gttgagtgcctgtggcttttccaggcacagggtgcaagctgccagtggatctaccattct
caggtctggagggtggtgacccctttctcacagctccaccaggcagttccccagtggaga
ctgtgtggggccttcaaccccacatttcccctccaaactgccctagtaggggttctctgt
gagggttccacccctacagcaggcttctgcctgggtaccc
>IGR2283a
tccaggcacagggtgcaagctgccagtggatctaccattctcaggtctggagggtggtga
cccctttctcacagctccaccaggcagttccccagtggagactgtgtggggccttcaacc
ccacatttcccctccaaactgccctagtaggggttctctgtgagggttccacccctacag
caggcttctgcctgggtaccctggctttcttgtacatcctctgaaatctaggtagaggct
gccaagcctccttcactcttacagtctgcatgcctgcatgcttaacaccacatggaagct
gccaaagcatatggcttttgctctttggagcagcagcctgagctgtacctgaggcccctt
gagccacagctggagctggaacagcctggatgtagggagcactgtcctaaggaggctgtg
cagagccatggggtcctaggcctagcccatgaaatgattcttcctcctaggtctctgggc
ctgtgcctgtgatggcaagggctgcccctgagatctctgaaatgccttcaaggccttttt
cccattgtcttagctattagtacctggctctcttttagttattcaaatttctctagcaag
tggttgctccacagcctgcttgaattcctctactgaaaatgcttctgctttctctatcac
atggccaggctgcaaattttctaaagttttacactctgct
>IGR2284a
ggctgcccctgagatctctgaaatgccttcaaggcctttttcccattgtcttagctatta
gtacctggctctcttttagttattcaaatttctctagcaagtggttgctccacagcctgc
ttgaattcctctactgaaaatgcttctgctttctctatcacatggccaggctgcaaattt
tctaaagttttacactctgcttcccctttaaatataacttctaactttaagtcatttttt
ttgctctcacatctgagttaagctgttagatgcagccatgtaacttcttgaacactttgc
tgcttagaaatttcctctgccagataccctagttgtcactctgaagttcaaacttccaca
gatccttacagcatgaacaaagtgcagccaagttctttgctaggccataatgagggtggc
ctttgctccatttctaggttcctcatttccatctgagacctcatcagccacgccttcact
ttccatatcaccatcagcattctggttacaaccatttgaccagccaagtactattctaac
ttctgagaatacagaagtgctcctcatggaacttacagtctagtggaggaagaaggacaa
taaatgcaacaaagaagtaaattagtcaggatgtcagagagtgataagtcccatggagaa
aaatgaagcaggagaaaaatgaagcagggatgcataaagt
>IGR2285a
ttctggttacaaccatttgaccagccaagtactattctaacttctgagaatacagaagtg
ctcctcatggaacttacagtctagtggaggaagaaggacaataaatgcaacaaagaagta
aattagtcaggatgtcagagagtgataagtcccatggagaaaaatgaagcaggagaaaaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-169
tgaagcagggatgcataaagttagttcagagagagaacaggatacaattttaaatagtgt
ggtcagataagggtttattaaggaggtggcatttgggccaagacactaaggaagtaagag
aacaagctatgtagatagctgggaagagcattcctaggaagagggaacaagtatctaata
gagaagcatgtctagtatgttcaaagaatagcaaagccttggtagccttaatgaagaaag
caatggagagagtaataagagatgatgtcagcgagctaaaggagggcatgaagattagag
tagggccctataaactggatgaccactgtcaaatgaaattaaggctgttgaggcagaaat
gatttgataaaagtttattggaagccaaatgtgaggatgaacccaggaaaacacaccaac
aaagttgagagtgttctggagtctgttacaagttggaaagttagaagacaggagggggac
tcttcatacaggagttgtcctttttcactggagggtacaa
>IGR2286a
tgaccactgtcaaatgaaattaaggctgttgaggcagaaatgatttgataaaagtttatt
ggaagccaaatgtgaggatgaacccaggaaaacacaccaacaaagttgagagtgttctgg
agtctgttacaagttggaaagttagaagacaggagggggactcttcatacaggagttgtc
ctttttcactggagggtacaatacaaaggttacaataattggctacagattgcaacatgc
agactaacatgtctacatgcaagacaatcagtaaaatgttatgactcagaaataaatcag
tgtccttttcagtgtcagtaggtggtgcattgatcagtacatcaacaatttgaggaactt
ctaagattccttactcaggacaaggtatcgccatgaatcacaagaccttcccaagatggg
ttaatttggaagctgtttacttttaaagtaaactgtcaaatgtgacctgtaggttattgc
catatataatttgtcatccaaattaggagacttctagaatgaaagttggaggtgagggtt
attaatcattaacactagggctggttgccgtggctcacgcttgtaatcccagtactttgg
gaggctgaggcaggcagatcacgaggtcaggggattgagaccatcctggccaacatggtg
aaaccccgttctctactaaaaaatacaaaaaaaaaaaaaa
>IGR2287a
aaattaggagacttctagaatgaaagttggaggtgagggttattaatcattaacactagg
gctggttgccgtggctcacgcttgtaatcccagtactttgggaggctgaggcaggcagat
cacgaggtcaggggattgagaccatcctggccaacatggtgaaaccccgttctctactaa
aaaatacaaaaaaaaaaaaaatttagctgggcatggtggcacatgcctgtaatcccagct
actcagaaggctgaggcaggagaattgcttgaaccagggagtcggaggttgcagtgagct
gagatcatgccactgcactccagcctggcaacagagcgagactccgtctcaaaaaaaaaa
aaaaaaaaagttaacactagttcagtggagagaagccaggactgtgctggacaaactctg
acgtgtaatcattctacttatagaccattgtaaggacttgggctttcaaaaaatctgact
gagatgggaagcgattggaaggttttgagcagaaaagtaacatgatgtgattgagatatc
cctgactactatgctgagagtagattgaaggggcgtaggagcagccttaatgaagaagga
ttggctgggggctaacagaatgcagggaagaaactggattctgcatatgttgaaattatg
gcaaaagattttattgacagattggatgtggagtacaaga
>IGR2288a
aggttttgagcagaaaagtaacatgatgtgattgagatatccctgactactatgctgaga
gtagattgaaggggcgtaggagcagccttaatgaagaaggattggctgggggctaacaga
atgcagggaagaaactggattctgcatatgttgaaattatggcaaaagattttattgaca
gattggatgtggagtacaagaggaagagcagccaggaaaataaagtttccatttactgag
ttggggaggacttcaggaagagcagatttgggatgaaattaggagcacatgttaaatttg
acatgttatgtttgagacacctattatatatccaagtgaggatatcaagtgggcagttat
tatgtgagcctggagttcactctctctatgtgttggtggtcatcagtgcagagatgatat
ttaaatcatgagactggattttttaaaaaggaagaggactgaagactaagttctgggcac
tccaattttgggcagtagcggagatgaagaaaaaccagcacactagatggtaaaggagca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-170
gccaacaaggtaagaggaaaaccaagcaagtgtcatttttgttgatttttttgatacaga
gtctcactctgtcactcaggctggagtgcaatgacacaatctcggctcactataacctct
gccttctgggtccaagtgtttttcttgcctcagcttccca
>IGR2289a
ggagatgaagaaaaaccagcacactagatggtaaaggagcagccaacaaggtaagaggaa
aaccaagcaagtgtcatttttgttgatttttttgatacagagtctcactctgtcactcag
gctggagtgcaatgacacaatctcggctcactataacctctgccttctgggtccaagtgt
ttttcttgcctcagcttcccaagtagctgggactgcaggtgtgtgccaccacgcctggcg
caagtgtcatgtagaaagcagttcaaggatgaaagagaaatgagtttgtcaaatgccttg
agaggtcaggtaagatgatgactgtgaattgactattgaattcagaaacatgcaggtcac
tgcggaccttgatagaggtgctctggtgaaaggtgagggctaaagcttaattgtagtggg
gccaagtgaaaattggaagaacaaagttgaaagtagcaagtagatatagcaatcttccaa
ggagtttcactgctaagggacagggagaaatggggcaggagctgacagcagaaactgggt
caagagagagcttttacagcctctttgcatactgaatgggaaagatccagtagagaggga
aaagatttatgatgggggagtcaggagaattgctagagcaacatgtgctcctaatttcat
cccaaatctgctcttcctgaagtcctccccaactcagtaa
>IGR2290a
acagggagaaatggggcaggagctgacagcagaaactgggtcaagagagagctritacag
cctctttgcatactgaatgggaaagatccagtagagagggaaaagatttatgatggggga
gtcaggagaattgctagagcaacatgtgctcctaatttcatcccaaatctgctcttcctg
aagtcctccccaactcagtaaatggaaactttattttcctggctgctcttcctctcgtac
tccacatccaatctgtcaataaagtcttttgccataatttcaacatatgtagaatccagt
ttcttgcctgtattctgttagcccccagccaatccttcttcattaaggctgctcctacgc
cccttcaatctactctcagcatagtagtcagggctatctcaattacatcatgttactttt
ctgctgttggtaagggagtagggggtgggggaggggtaagaagtatataaggctggggcc
gggcacagtggctcacacctataatcccagcactttgggaggctgaggcaggccaatcac
ttgagcccaggagttcagtactagcctagccaacatggcaaaaccctgtctctactaaaa
atacaaaaattagctgggtatggtggtgcatgcctgtaatcctagctacttcggaggctg
aggcatgagaatcgtttgaacctgggaggcagaggttgca
>IGR2291a
tataatcccagcactttgggaggctgaggcaggccaatcacttgagcccaggagttcagt
actagcctagccaacatggcaaaaccctgtctctactaaaaatacaaaaattagctgggt
atggtggtgcatgcctgtaatcctagctacttcggaggctgaggcatgagaatcgtttga
acctgggaggcagaggttgcagtgagccactgcactccagcggggaggagagaccattca
ggagaaacgggagaaaagacagagggtgtgggtacagatggagttaggctggtggattat
gctgcttgtagaggttctctccattgcttctattttctaggtgaaataggaagccaaggc
acagctgagggtgatcatgggggaggaggtgatggagttctgaagagaaagaaggtcttc
caggatagagaatgaaccagggcaattaggatcctcttgaagtcactgatggtcagttta
aagtgaaaccagtcagatggaatatattttccatctacatttggctatgcaggtgctagc
aagaagtaggagggaggttagatttaaccagctttatagtttcccacaaaagcaaggcag
ataagaaaggggcaaggaagatgattatgatgattaagcatggaatttaagctggccaag
aaggggtgtgaggacatgagtaagatgagagatagcaaaa
>IGR2292a
gaatatattttccatctacatttggctatgcaggtgctagcaagaagtaggagggaggtt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-171
agatttaaccagctttatagtttcccacaaaagcaaggcagataagaaaggggcaaggaa
gatgattatgatgattaagcatggaatttaagctggccaagaaggggtgtgaggacatga
gtaagatgagagatagcaaaaacgtggacatctttgccaggtatggagccaaacacagta
tgcattgtctcatgtaatccccacccaaatggaattgttatcatccctctttacagatga
agaagctgagttttagggaagactgtaacttgctcaaagtcacacagctgatagagaagt
gacacacccagcatcaggtcctggaacacttgtctccaaaggctatgtacttagccctat
ttgctttaactggagtattagtgggcattacaaaaattgatgcatatgtacaaaggatgg
taattttgtccagtatgtttttgttaatacttttccaacttgagttaattttaagatttt
ctgttgtacagaattctttaaaagtttatagtaaaatctatttatcttcaatttcctatt
catcttaaaattaaatgtcacctatattttcttctagcttttgatttatttactcttggc
tctattttatttacatttattacatttggctctttagttg
>IGR2293a
tttgttaatacttttccaacttgagttaattttaagattttctgttgtacagaattcttt
aaaagtttatagtaaaatctatttatcttcaatttcctattcatcttaaaattaaatgtc
acctatattttcttctagcttttgatttatttactcttggctctattttatttacattta
ttacatttggctctttagttgatcaggaattaatttggtatgtggtttatggtgggatac
tatttattcccccagtttttccatttttaccagttcttcagcttgtcgattgtcccagca
ccagtcttcaacaatgtatcattttcttgataatttataattcatctttatcatatgtta
caatttttcaacacttgggtctgtttctgtgatacctcttctatttcgttgattgattta
tcttttgtgtgtgtgtctgtgtgtgtgtgtgtgtgtttgtgtgttttccaggaaacccag
agtagtgtagtcattgtgtgtttttatatatgtaagagaacatttccccttatcaatgat
ctttttcaaaaatttcttaaacatattacatatttcttttttcagatgctctttacaaat
attttttaacttcttaaaatatctcattgaggattccgttccaagatggccaaataggaa
cagctctggtctgcagctcccagtgtgatcgacgcagaag
>IGR2294a
gtttttatatatgtaagagaacatttccccttatcaatgatctttttcaaaaatttctta
aacatattacatatttcttttttcagatgctctttacaaatattttttaacttcttaaaa
tatctcattgaggattccgttccaagatggccaaataggaacagctctggtctgcagctc
ccagtgtgatcgacgcagaagacggatgatttctgcatttccaactgaggtacctggttc
atcttactaggactggttggacagtgggtgcagcccacggagggtgagccgaagcagggc
agggcatcgcctcacctgggaagcgcaaggagtcaggggatttccttttcctagccaagg
gaagccgtgacagatggtacctggaaaaacgggacactcctgcccaaatactgcgctttt
ccaaagtcttagcaaatggcacaccaggagattatatcctgtgcctggctcgacagatcc
tatgtccatggagccttgctcactgctagtgcaacagtctgagattgacctgcaaggcag
caacctggcatggggaggggcatccgccattgctgaggcttgagtaggtaaataaagtgg
ctgtggaagctcgaactgggtggagcccaccacagctcagcaaggctgactgcctctgta
gtctccacctctggggcagggcatagctgaacaaaaagca
>IGR2295a
tcactgctagtgcaacagtctgagattgacctgcaaggcagcaacctggcatggggaggg
gcatccgccattgctgaggcttgagtaggtaaataaagtggctgtggaagctcgaactgg
gtggagcccaccacagctcagcaaggctgactgcctctgtagtctccacctctggggcag
ggcatagctgaacaaaaagcagcagaaacttctgcagacttaaacatccctgtctgacag
ctctgaagagagcagtggttctcccaggatggtgttttagcttggagaacagacagactg
cctcctcaagtgggtccctgacccccatgtagcctaactgggagacacctcccagtagcc
gactgacacctcatacaggcaggtgcccctctgggatgaagcttccagaggaaggatcac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-172-
tcagcaatatttgctgttctgcaatatttgctgttctgcagcctctgatggtgataccca
ggcaaacaggtctggagtagacctccagcaaactccaacagacctgcagctgagggacct
cactggtagaaggaaaactaacaaacagaaagaaatagcatcaacatcaacaaaaaggac
atccacaccaaaaccccatctgtaagttaccaacatcaaagaccaaaggtagataaaacc
acaaagatggggagaaaccagagcagaaaagctgaaaatt
>IGR2296a
gacctccagcaaactccaacagacctgcagctgagggacctcactggtagaaggaaaact
aacaaacagaaagaaatagcatcaacatcaacaaaaaggacatccacaccaaaaccccat
ctgtaagttaccaacatcaaagaccaaaggtagataaaaccacaaagatggggagaaacc
agagcagaaaagctgaaaattctaaaaaccagagcacctcttctcctccaaaggatcaca
actccttgccagcaatggaacaaagctgggtggagaatgactttgacgagctgacagaag
tggacttcagaaggtcagtaataataaacttctcccagctaaaggaggatgttctaaccc
atcgcaaggaagctaaaaaccttgaaaatagattagacgaatggctaactagaataaaca
gtgtagagaagaccttaaatgacctgatggagctgaaaaccatggcacgagaactttgtg
acacatgcacaagcttcaatagccgattcgatcaagaaaggatatcagtgattgaagatc
aaattaatgaaataactcaagaagattagagaaaaaagagtaaaagggaacgaacaaagc
ctccaagaaatatgggactatgtgaaagaccaaatctacgtttgattggtgtacctgaaa
atgacagggagaatggaaccaagttggaaaacactcctca
>IGR2297a
tagccgattcgatcaagaaaggatatcagtgattgaagatcaaattaatgaaataactca
agaagattagagaaaaaagagtaaaagggaacgaacaaagcctccaagaaatatgggact
atgtgaaagaccaaatctacgtttgattggtgtacctgaaaatgacagggagaatggaac
caagttggaaaacactcctcaggatattatcaaggagaacttccccaacttagcaaagca
ggccaacattcaaattcaggatatacagagaatgccacaaagatactcctcaagaagagc
aaacccaagacacataattggcagattcaccaaggttgaaatgaaggaaaaaatgttaag
cgcagccagagagaaaggtcgggttacgcacaaagggaagcccatcagactaacagcgga
tctctcggcagaaaccctacaagcccgaagagagtgggggccaatattcaacattcttaa
agaaaagaattttcaacccagaatttcatatccagccaaactaagcttcataagtgaaga
ataaaatcctttccagacaagcaaatgctgagagattttgtcaccaccaggcctgcccta
aaagagctcctgaaggaagcactaaacatggaaaggaaaaaccggtaccagccactgcaa
aaatatgccaaattgtaaagaccatcgatgctatgaagaa
>IGR2298a
agaatttcatatccagccaaactaagcttcataagtgaagaataaaatcctttccagaca
agcaaatgctgagagattttgtcaccaccaggcctgccctaaaagagctcctgaaggaag
cactaaacatggaaaggaaaaaccggtaccagccactgcaaaaatatgccaaattgtaaa
gaccatcgatgctatgaagaaactgcatgaactaacaagcaaaataaccagctaacatca
taatgacaggatcaaattcacacataacaatattaaccttaaatgtaaatgggctaaatg
ccccaattaaaagacacagactggcaaattggataaagagtcaagacccatccgtgtcct
gtattcaggagacccatctcacgtgcagagacacacataggctcaaaataaagggatgga
ggaagatctaccaagcaaatggaaagcagaaaaaagcaggggttgcaatcctagtctctg
attaaacagactttaaaccaacaaagatcaaacgggacaaagaaggccattacataatgg
taaagggatcaattcaacaagaagagctaactatcctaaatatatatgcacccaatacag
gaacacccagattcataaaacaagtccttagagacctacaaagaaacttagactcccaca
caataataatgggagactttaacaccccactgtcaatatt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-173
>IGR2299a
aacaaagatcaaacgggacaaagaaggccattacataatggtaaagggatcaattcaaca
agaagagctaactatcctaaatatatatgcacccaatacaggaacacccagattcataaa
acaagtccttagagacctacaaagaaacttagactcccacacaataataatgggagactt
taacaccccactgtcaatattagacagatcaatgagacagaaggttaacaaggatatcca
ggacttgaactcagatctgcaccaagcagacttaatagacatctacagacctctccaccc
caaatgaacagagtatacattcttctcagcaccacatcacacttattccaaaattgacca
catagttggaagtaaagcactccttagcacatgtaaaggaacagaaatcacaacaaactg
tgtctcagaccacagtgcaatcaaattagaactcaggattaagaaactcactcaaaactg
cacaactgcatggaaactgaacaatctgctcctgaatgactactgggtaaataacgaaat
gaaggcagaaataaagacgttctttgaaaacaatgagagcaaagacacaacgtgccagaa
tctctggaacacacttaaagcacggtatatagggaaatttatagcactaaatacccacaa
gagaaagcaggaaagatcaaaatcaacaccctaacatcat
>IGR2300a
aacaatctgctcctgaatgactactgggtaaataacgaaatgaaggcagaaataaagacg
ttctttgaaaacaatgagagcaaagacacaacgtgccagaatctctggaacacacttaaa
gcacggtatatagggaaatttatagcactaaatacccacaagagaaagcaggaaagatca
aaatcaacaccctaacatcataattaaaagaactagagaagcaagagcaaacaaattcaa
aagctagcagaaggcaagaaataactaagatcagagcagaactgaaagagatagagacac
aaaaacttcaaaaaaatcaacgaatccaggagctcgttttttgaaaagatcaacaaaatt
gatagactgttagcaagactaataaagaagaaaagagagaagaatcaaatcgatggtata
aaaagtgataaaggggatgtcaccaccaatcccacagaaatacaaactaccatcagagaa
tactataaacacctctacacaaataaactagaaaatctagaagaaatggataaattcctg
gacacatacagcctcccaagactaaaccaggaagaagttgaatctctgattagaccaata
acaggctctgaaattgaggcagtagttaatagcccaccaaccaaaaacagtccaggacca
gacagattcacagccaaattctaccagaggtacagaggag
>IGR2301a
caaataaactagaaaatctagaagaaatggataaattcctggacacatacagcctcccaa
gactaaaccaggaagaagttgaatctctgattagaccaataacaggctctgaaattgagg
cagtagttaatagcccaccaaccaaaaacagtccaggaccagacagattcacagccaaat
tctaccagaggtacagaggagctggtaccattctttctgaaactattcctagcaatagaa
aagagggaatcctccctaattcattttatgaggccagcatcatcctgataccaaagcctg
gcagagacacaacaaaaaaaagagaggccgggcgcggtggctcacgcctgtaatcccagc
actttgggaggccgaggcgggtggatcatgaggtcaggagatcgagaccatcctggctaa
caaggtgaaaccccgtctctactaaaaatacaaaaaaattagccgggcgcggtggcgggc
gcctgtagtcccagctactcgggaggctgaggcaggagaatggcgtgaacccgggaagca
gagcttgcagtgagccgagattgcgccactgcagtccgcagtccggcctgggcgacagag
cgagactccgtctcaaaaaaaaaaaaaaaaagagaattttataccaatatccctgatgaa
catcgatgcaaaaatcctcaataaaatactggcaaaccga
>IGR2302a
cgggaggctgaggcaggagaatggcgtgaacccgggaagcagagcttgcagtgagccgag
attgcgccactgcagtccgcagtccggcctgggcgacagagcgagactccgtctcaaaaa
aaaaaaaaaaaagagaattttataccaatatccctgatgaacatcgatgcaaaaatcctc
aataaaatactggcaaaccgaatccagtagcacatcaaaaagcttctccaccacgatcaa
gtgggcttcatccctgggatgcaaggctgtttcaacatatgcaaatcaataaacataatc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-174-
catcacagaaacagaaccaatgacaaaaaccgcttgattatctcaatagatgcagaaaag
gccgtcgacaaaattcaaaagcccttcatgctaaaaactctcaataaactaggtattgat
agaacgtttctcaaaataataagagctatatatgacaaacccacagccaatatcatgtgg
aatgggctaaagctgttgacctgatagatatgggttcaagaggacacagctgaatactgt
gcttaggaaaagaacagtttcaaaggctttccagattgtcagatttgatgatatcctcct
tggtgcacacctctcttggctatggggcacataaaccacctctaccaatctaactggttt
gtgcagtttttctgattttgtatctaccggcaaaatatat
>IGR23 03 a
cctgatagatatgggttcaagaggacacagctgaatactgtgcttaggaaaagaacagtt
tcaaaggctttccagattgtcagatttgatgatatcctccttggtgcacacctctcttgg
ctatggggcacataaaccacctctaccaatctaactggtttgtgcagtttttctgatttt
gtatctaccggcaaaatatatcttaagccatttttaggaaacaggaggtttagtcacgtg
ctcaacaaaagcacaacaaatggggagcatttaatggtgtaagggctgtgaggtgtagct
gctgaaactgtagctaggagctgccttgctgccttcttgcaggcagattggccagatgag
ccaggctaaaatacaattaatatctaccattgtggtttaatatgaaatatggatacctgg
tctttgtctcagttcttgtcatagagttccccaaacctttagaacttcctgagtggtagg
aatatctcattagtgataatgagcccctttgattcgataactcctgagtttatgctaatg
aggttacttaatgtggggccctagatattcttaggatggggctagttcccggaaagacca
ggtcatttgaggattagagggttggaacttttagctctacccactgatctctgggtgggg
aaggtgctggagatcaagctgcctaaaaactcttgaacaa
>IGR2304a
tgagcccctttgattcgataactcctgagtttatgctaatgaggttacttaatgtggggc
cctagatattcttaggatggggctagttcccggaaagaccaggtcatttgaggattagag
ggttggaacttttagctctacccactgatctctgggtggggaaggtgctggagatcaagc
tgcctaaaaactcttgaacaacaagatttgaggagcttccagtaaatgcgtccacaagct
gggagggcactgcaccccagtttcactgggacagaagctcttgcacttggaatctttcca
gacctagcccttcatgctgcttcatctggctgttcatctgtatcctttataataaattgg
caaatgtaaaggtttagctgaatttggtgagcctttctagaaaattaattgaacctaaga
aggggtctgtggaaaccctggtttgtagttggtaggtcagaggtgcgtgtggcttggatg
ttcgaatggcatctgaagagggacagagcacacaacctgtgggatctgacactatctccc
cgcagatagggtcagagcttaattctattagagaacaccccattggtatctgctggagaa
ttacttggtgtatgagaagccccccaccacatctggtcacagaagtattgtgggttgagt
gtgacagtacagggtaaaaagtggtttgttttttcctcta
>IGR2305a
gggacagagcacacaacctgtgggatctgacactatctccccgcagatagggtcagagct
taattctattagagaacaccccattggtatctgctggagaattacttggtgtatgagaag
ccccccaccacatctggtcacagaagtattgtgggttgagtgtgacagtacagggtaaaa
agtggtttgttttttcctctaacagtgatcactccctctcaaaggagtgtggaaggtttt
ctggataggaatactgcatataatcatttggttcacttcagaaactactataattttgac
tgtgctggttcacttccacatgtacaaacacacacacatacacacacattgttgtcacct
aatatttgcgttaatacaatgatgttatttttatttggatagtatttgtatgattggaaa
tgagtgttaatctttatatgtattttaccagtccttgactaacatgttttcaagacatct
taccaatccatttcattgaattaatgagtaaggagactctctagaaatggttggtttgta
aagcaaggacattatctggaagaatcatccagagtttactgtatgacgagcatttcttga
tagcaaggttcattttggtgtcaatcgttacagtcagtccatttcagtgggaacaacgaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-175
tttctccacagggtcttatttttctgtttttcacttcacc
>IGR2306a
attaatgagtaaggagactctctagaaatggttggtttgtaaagcaaggacattatctgg
aagaatcatccagagtttactgtatgacgagcatttcttgatagcaaggttcattttggt
gtcaatcgttacagtcagtccatttcagtgggaacaacgaatttctccacagggtcttat
ttttctgtttttcacttcaccaaatggggtagatattttttcagaatgcagttattagaa
ccttgggattttcttctgtctccattgagtctcttgtttttttcccagatctgaacctga
aaataaaatagatgctaaggaaaattaaatattcaagactttcctcctcaaaatgctcca
tccaaattgacattgaaaaatatttctccaatcaatgaacaagtaactatttgaactcta
atgagaacctcatggtgtagatctaatattttatgcttttaaacatctgaggctactttc
ttaattaagcatagaagccagaatttaaactctttcacagttttcccaagcaaaggatag
agagggaggcatgaaattcttggcaattaaagttgatactgaagtagttctatcattaga
agaaaacaacttatcaacaatgggcactttttgctataaatgttctgtcagggatcagaa
ttaattcatatgcagagttacctttatcaaggccaggcac
>IGR2307a
agaatttaaactctttcacagttttcccaagcaaaggatagagagggaggcatgaaattc
ttggcaattaaagttgatactgaagtagttctatcattagaagaaaacaacttatcaaca
atgggcactttttgctataaatgttctgtcagggatcagaattaattcatatgcagagtt
acctttatcaaggccaggcactgggaacactttatcttttataacctcaaaatagccgta
tgaaatatcccatatagcagatgggaatactgaagcttagtgaatattaagtgatatgcc
caaatttttgcagtagatttgggatttaaagccaggcagtgttactcgaaactctaaact
tctcctaaataccactaatcttttaaatgtttgctgtggtgtcataaaaagatactggtc
tttgtccctggctcctaacatagagatcctaaatctcttataatttctggagtgataggg
agtgataaaagcttcttttgttctaatgaggcaacccttggctgggcccttagatagctt
cagggtgggggctggtcaccagaagactaagcctggattagaagcctggaacctctgggg
agaggagagaggctggggatagacttaataatccatcatgccaacatgactaaacctcca
tgaaaacctctaaatgatggggtttggagaacttccgagt
>IGR2308a
gttctaatgaggcaacccttggctgggcccttagatagcttcagggtgggggctggtcac
cagaagactaagcctggattagaagcctggaacctctggggagaggagagaggctgggga
tagacttaataatccatcatgccaacatgactaaacctccatgaaaacctctaaatgatg
gggtttggagaacttccgagttggtgaccacatccacatgccaggagggcagtgcacctt
aactccgtagggacagaacctctgcactcaggacccttccagacctctctgtatgtacct
cttcatctggctgttcatttgtatcctttgtaagaaaccgctagtggccagtgttctgag
tgctgtgagtcattctagcaaataatcaaacccaaggaggggatttgttggaaccccaga
cttggtagcaaagtcagagagaaatgtgggtaacctggggacctgacatttgtgagtggc
aagtgaagcaaggcagtattgtgggactgagtctttacacctgtggagtctgatgctaaa
tttaggtattgtcaaaattgaactgcattataggacactcaataggtgtcagaattggtt
tgcgtcaagaagaaaaacccttgcgcaatctcataagccaaaaaaagatgttgaattgtt
ttatttttgcatttccttattaatgtggacaaataacttt
>IGR2309a
tgtgggactgagtctttacacctgtggagtctgatgctaaatttaggtattgtcaaaatt
gaactgcattataggacactcaataggtgtcagaattggtttgcgtcaagaagaaaaacc
cttgcgcaatctcataagccaaaaaaagatgttgaattgttttatttttgcatttcctta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-176-
ttaatgtggacaaataacttttttcatgtatatattggacactgaagtgacttcttctgt
aaactgtctgttcttgtcctttgctggttttcctactgaattgtttgtctttttctcact
ggttactatgagctttttgtatattaagtatattagccttatgtttaggttttgtgtagc
aaatattttctcctggcttattgacttttgtctttgtgggtggtttctttttgccttgcc
aataatttaaaaaatgtacaatcagatatatcaatctgttcctttatggttctttgattt
tatgttatgctcagtaagatcttctctaaggttataaaaatgtttgtttcctcctggtat
atttatgattttacatttttaggcctaaattttttaactgtctggattttatcttgatgt
gttttttttttggagacggagtctcgctctgtcacgcagactggagtgtagtggcgcgat
ttcggctcactgcaacatccaccaccctggttcaagcgat
>IGR23 I Oa
tcttctctaaggttataaaaatgtttgtttcctcctggtatatttatgattttacatttt
taggcctaaattttttaactgtctggattttatcttgatgtgttttttttttggagacgg
agtctcgctctgtcacgcagactggagtgtagtggcgcgatttcggctcactgcaacatc
caccaccctggttcaagcgattctcctgcctcagcctcccgcgagctgggattacagggg
tgcgccaccatgcctggctaatttttgtatttttagtagagatggggtttcaccatgttg
gacagactgttctcgaactcctgacctcaagcaatctgcctgcctcaatctccctaagtg
ctgggattacaggtgtgagccaccatgcccagccaatgcattttttaaagagacaacttt
ttaatttattcaaaatgtctagctgaatgttctaataccttttactgaataactattccc
ccttgactttgctactttttattacatactgaatttttatattttcttgggttttatcct
gaactctatcctattccattggtttctattcctataccattatcacattgttttaattac
tattgctcaacaatatgctttattactattattattatttttgagacagagtctagctct
gttgcccagtctggagtgcggtggcatgatgttggctcac
>IGR2311 a
tattacatactgaatttttatattttcttgggttttatcctgaactctatcctattccat
tggtttctattcctataccattatcacattgttttaattactattgctcaacaatatgct
ttattactattattattatttttgagacagagtctagctctgttgcccagtctggagtgc
ggtggcatgatgttggctcactgcaacctccacctcccgggttcaagcaattctcctacc
tcagcctcctgagtagctgggactacaggtgtgtgccaccatgcccagctaatttttgta
tttttagtagagacagggtttcaccatgttggccaggatggtctcgatctcttgacctca
tgatccgcctgcctcagcctcccaaagtgttgggattacaggcatgtgccaccgcgcctg
gcctattatttatttattttttttgagacggagttttgctcttgttgcccaggctggagt
gcagtggtgtgatctcagctcactgcaacctctgcctcctgggtcaagcagttctcctgc
ctcagcctcctgagtagctgggattacatgtgactgccaccacacccagctaattttttg
tatttttagtaaagatgaggtttcacta
>IGR 1 OOOa
ggctctgactaaagaatatgacagatcagatattcctctccacctgctcccctcccccat
ccctttttagagggctggggaaattttagtttttaatcaaaggctttatttctccagttg
tgcaaaggaatttaactgggactttacaactgaataaagtatttctcagagtcgatacta
atcttagcaagaggatattgcctaacccaacctaaaagcagcagagtcattacagaaata
ttatgttggccttgatttctaccccaccatgagttatgctactcaccaggtagcctgttt
tgtttttcatttttagagacagggtctcactctgtcacccaggttggagtgcagtgtcac
aatcatagcttactatgacctcaaactcttaggctcaaatgatccacctcagcctcccaa
gtagctgggaccacaggtgtctgccactacacttggctaattttttaattttttgtagag
ataggagcttgctaagttgcccaggttggtttggaactcctggcttcaagcagtcctccc
gccttgggctcccaaagtgctgaggttacaggcgtgagccactgtgcccagcatgtgccc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-177-
tgttttaagtgtatctcctgctgtagtccgttacatgtgcacatctcttctgtgtttact
gtgtacctgctctatgctgagaagaatgtcttttcaaaac
>IGR1001a
cccaggttggtttggaactcctggcttcaagcagtcctcccgccttgggctcccaaagtg
ctgaggttacaggcgtgagccactgtgcccagcatgtgccctgttttaagtgtatctcct
gctgtagtccgttacatgtgcacatctcttctgtgtttactgtgtacctgctctatgctg
agaagaatgtcttttcaaaactcacaccctcccttaggagagagaggtggccacatgaat
ggagaatgactgcatagcatgctgagggctgtggtaaaagaggctgaatggtgagctgcc
aggtacggcatccttcctgtgcagctgacatggtgcctgacacatgtctgcctgaccaaa
ggggcagaagaggcttctcaggggaagttctgtttgaggtcttcagcagttcaacagctg
gggaaaggtattccaggagcgagtgagtttggatgccatgtgcgttggtggtgtgcttga
agtagagcaaacggggtggaggcaaatgagcctgaaaaggaaagagatgggacaggatcc
tactgtggaagagttttctgtaagcagtgggaagccacagaaggattttaagtgggccat
tcacattgtgttttattttgagacagggtctcactgtcacccaggctggagtacagtggc
atgatcaaggctcactgaagcctcaacctcccaggctaaa
>IGR1002a
aggcaaatgagcctgaaaaggaaagagatgggacaggatcctactgtggaagagttttct
gtaagcagtgggaagccacagaaggattttaagtgggccattcacattgtgttttatttt
gagacagggtctcactgtcacccaggctggagtacagtggcatgatcaaggctcactgaa
gcctcaacctcccaggctaaagcaatcctcctgcttcaacctcccaattagctgagagca
cagctgtgtaaaaatttaattttttttttttttgtagagacaggatgttggccaggctgg
tctcgaacttttgggttcaagcgaagctcccatctcagtctcccaaagtgccgggattac
aggcgtgagccactgcacctggcctatttgtgttttagaaaaacaactgctgggccgggt
gtggtggctcacccctgtaatcccagcactttgggaggttgaggcaggtggatcacgagg
tcaagagattgagaccatcctggccaacatggtgaaaccccgtctctactaaaaatacaa
aaaaatttacctgggcgtggtggcatgcacctgtagtcccagctacttgggaggctgagg
caggagaatcacttgaatcccgggggcggagattgcagggagccgagatcgcaccactgc
actccagcctagtgacagagtgaaattctgtctcagaaaa
>IGR1003a
ctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaatttacctgggcgtg
gtggcatgcacctgtagtcccagctacttgggaggctgaggcaggagaatcacttgaatc
ccgggggcggagattgcagggagccgagatcgcaccactgcactccagcctagtgacaga
gtgaaattctgtctcagaaaaacaaaacaaaacaaaaagaaacaactgctggagagtttg
tgaaggattagagggagcaagacgggatgctggttgggatggtggttgggagagcagatg
ctatacacacctgtgtcccggaggtggaaagggtcatcagccagaggagtaaccgccctc
tcttctcagctgttttgcttgcactcgtgattggtataaactgagggagcaaatgtgtgt
cctcttattcacgttgcctagtaagtacccaggtgtgcagtgagcatacaaaacatcaaa
acatattttcgtttggctgaactctggctaatcagaaactagaaggaacagacagcttag
agacttaaagttggactaggaagaagttgacaggatggattagaagatagccactttagg
ctgggtacagtggctcatgcctgtaatcccagcactttgggaggccgaggtgggtggatc
acctgaggtcaggagttcaagaccagcctggccaacacag
>IGR1004a
aactctggctaatcagaaactagaaggaacagacagcttagagacttaaagttggactag
gaagaagttgacaggatggattagaagatagccactttaggctgggtacagtggctcatg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-178
cctgtaatcccagcactttgggaggccgaggtgggtggatcacctgaggtcaggagttca
agaccagcctggccaacacagtgaaaccccatctctactaataatacaaaaaaatgaggc
aggtgtggtggcaggcacctgtaatcccagctactcaggaggctgaggcaggagaatngc
ttgaanctgggaggtggaggttgcagtgagccaagatcnngccantgcactcnagcctgg
gngncagagcgagantctgtntnannaaaaaaaaaaaaaaaaaaaaaaaaannncaacac
tttagagagccaaggagagggtgtctgggtacttagggcaaaagcccagttgaggaaacg
ctgggcgtgacagctaactggggattttagtactccacctgggaatggaactcaaacttg
agctaataaattgaatctagaaatcagccccaaggctagagaaagtgcctgccttgctcc
tagtggaagctactagaaactgagaagccaaccctgtgtgtcataggccaggctgtgcct
agctccataaggaagctctgcgttgtgcttagccttgaga
>IGR 1005 a
ggggattttagtactccacctgggaatggaactcaaacttgagctaataaattgaatcta
gaaatcagccccaaggctagagaaagtgcctgccttgctcctagtggaagctactagaaa
ctgagaagccaaccctgtgtgtcataggccaggctgtgcctagctccataaggaagctct
gcgttgtgcttagccttgagattcccatccttagataatgtgggcaccctgagattatgt
gaaggagggcagagaaaaaccaagagcagggtcaatgacatggacagcaacaagcagagc
ccccttggcatttgtaacagaggtgaccctttgtaactgtagcccaacaatgtttccata
aaagacagccatagatttgagccaaatcattttttgattcatttttccaataaataatta
ttaccccctagatgccagttacagatagtttattcattggcaaaaggtggaggtatgata
gccaggagggaaaggttcagacttactgtcaatgtcatattccacacacagacaaaaggc
atgtcccatgaagcaggcacgggctgtggctgagtttgctacataaatgtgctcagatga
caagcatcttaactttcacttaatcctgaaggtttttcaccctctgttttttgttttgtt
tttttttttttgagacagaatctcgctctgccgcccaggc
>IGR1006a
gacttactgtcaatgtcatattccacacacagacaaaaggcatgtcccatgaagcaggca
cgggctgtggctgagtttgctacataaatgtgctcagatgacaagcatcttaactttcac
ttaatcctgaaggtttttcaccctctgttttttgttttgtttttttttttttgagacaga
atctcgctctgccgcccaggctggagtgcaatggcacgatcttggctcactgcaacctcc
acctcccaggttcaagcgattctcctgcctcagcctcccgagtagctggattacacgtgt
gcactagcatccccagctaatttttgtatttttagtagagacggggtttcgccatgttgg
ccaggctggtcttgaactcctgacctaaggtgatccgcctgcttcagtctcccaaagtgc
tggaattacaggcgtgagccactgcgcccggcctcacccactgtttttataagtatcccc
ctcaatttgtgttctcattgtcttcggaaattcaaaggcttgttgttgttgcatgtttgc
atccagagtccaggactgcctgactgggagtaaatggaaatgtgagttgcatcttgccta
atgaagcttatgtgatgacagacctgcttagagtctgcatgtgtcctttccatggcgtgc
tctaaatcttcctactttcctttaccatcctgtcctcata
>IGR1007a
gtcttcggaaattcaaaggcttgttgttgttgcatgtttgcatccagagtccaggactgc
ctgactgggagtaaatggaaatgtgagttgcatcttgcctaatgaagcttatgtgatgac
agacctgcttagagtctgcatgtgtccritccatggcgtgctctaaatcttcctactttc
ctttaccatcctgtcctcatatacaaactgtaacccactacccatatcctgtggcagact
acaactcacattagccattgaatgcaaatgagcctcaatcaaagaagaaaggaaattaaa
atttacagtatgtgtcttctccggttggcctgaggagcctccatgactctcatagctatt
tattgcccttggcatgctggtattttatgtgggcagggtgaaactggctgtggtcagggt
gagacttgaagcttttgatttgttcccttattttgaaagggttaaaaagatgttacatgt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-179-
tttggtgtaattttagtactcatattaattttgtcacatctctgtaagcgaggatgaaaa
gagagtgctcaatcactgttactagatccatattcttacagagaacaagtcttcaaaagg
caagttttgatgacacttgggtttttttcccccttttaatttcttttaaataacagcttt
attgagatagaattcacctactacgaaatttatcctttta
>IGR1008a
tcatattaattttgtcacatctctgtaagcgaggatgaaaagagagtgctcaatcactgt
tactagatccatattcttacagagaacaagtcttcaaaaggcaagttttgatgacacttg
ggtttttttcccccttttaatttcttttaaataacagctttattgagatagaattcacct
actacgaaatttatccttttaaagtgtacgagtcagtgctttttagtatgttcatagaat
tgtgcaaccatcaccattatctaatatccgaacattttcatcacccctgaaagaaacccc
accccccattatcagtcactccccatgcctccacacccgcctcccacccacagcctgtag
caatcaatattctatttttgcctctgtggattctcctgttctgaataattcatatcagta
gaatcataccatatgtggtcttctgcatttggcttctttcccgtcacatactgtttccaa
ggttcatccgggttgtggcctctgtcagtacttcatttctttttattgacaaataatatg
ccattgtatggatatgccactttttgtttatccatcagttgattgacattttggttgctt
ctacttttttttttttttctttgagacagggtcttattctgtcgctcaggctggagtaca
gcagcgcagtcatagctcattgtagcctcaacctcccagg
>IGR 1009a
ctctgtcagtacttcatttctttttattgacaaataatatgccattgtatggatatgcca
ctttttgtttatccatcagttgattgacattttggttgcttctacttttttttttttttc
tttgagacagggtcttattctgtcgctcaggctggagtacagcagcgcagtcatagctca
ttgtagcctcaacctcccaggcttgagccatcctcccacctcagcctctccagtagctgg
gactacaggcatgtgccaccatgctcagctagttttttgtagagacagggttttgccttg
ttgcccaggctggtcttgaactcctggcctcaagtgatcctcctgcctcggcctcccaaa
gtgctgggattacaggtgtgaaccactgctcccagccacttctacttttttgctattatg
aataatgttgctatgaacatttgtgtagaggtttttgtgtggacatgtgttcctagttcc
cttgggtatatacctaggattggaattgctggatcgtaaactattttatccttttgagga
actgccaattgttttccaaagtgactacaccatttttcaatcactccagcaatgtaggag
ggttccaatttttctacatcttcaccaacagttattgtcttttaaatgttatttctttaa
tgaaaaaacttcatttatgcacataacacacacacacaca
>IGR1010a
ttggaattgctggatcgtaaactattttatccttttgaggaactgccaattgttttccaa
agtgactacaccatttttcaatcactccagcaatgtaggagggttccaatttttctacat
cttcaccaacagttattgtcttttaaatgttatttctttaatgaaaaaacttcatttatg
cacataacacacacacacacacacacacacacacacacacacacacacacacacacacac
acacacacacacacacacacacacacagacttataatggaaagccgaaagtctccagccc
tgtttcacccctccttagtccaagtcccattcccagcaaaccatcttccatttttatttt
tagtttttccagtgactatcattataattccaaagattgcttgattcattattttttctt
ctctttttattatgaaaactttcaattatgtataaaaggagaatagtataaccaaccccc
tgtacacatccccagctgcaacaactgtcaacccatgaccacttttacccactgtttttt
gctttatcagtgttagatgtcatacattgatttccctattgaagaaagagaatttaccta
attctatcacttccaaatttttatagtaaattatttttagttcttctattacctttgtga
ttttgataaatccctaaaccttgtgttcttgttccatcca
>IGR 1011 a
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-180-
aacaactgtcaacccatgaccacttttacccactgttttttgctttatcagtgttagatg
tcatacattgatttccctattgaagaaagagaatttacctaattctatcacttccaaatt
tttatagtaaattatttttagttcttctattacctttgtgattttgataaatccctaaac
cttgtgttcttgttccatccactgtgcacagtgttatttaactgccctcttgtccatgca
agctggagatagcaatgcccacctctcttttcttctgctttcacctcccagccatttcca
gctatagctcttatattattcagtggatagcaatttatagtctgttctccaaccatcatc
aagtcttctgtgctttgtctattggttggttctaagacttgagaatcaagagaatttaca
ttattatgactttaaatatcgttcactgtagagccatatggtgtactgaggattacttct
tttttctgtagactcagtataacaatccttgtgccaatgggggaagaacgttttagacat
ccagttgataccttttctgttcagaaatatatggtaatccatagcactcttggacccaag
gtgtcttatttacatcttgtatggccttgtgttctttaattatcttgtgtgttatgtccc
taactcgagagggaacccctcgagggggaagtggtctttc
>IGR1012a
taacaatccttgtgccaatgggggaagaacgttttagacatccagttgataccttttctg
ttcagaaatatatggtaatccatagcactcttggacccaaggtgtcttatttacatcttg
tatggccttgtgttctttaattatcttgtgtgttatgtccctaactcgagagggaacccc
tcgagggggaagtggtctttcctgttttgctcccatagcatttatagtctcttggtaaac
taaattgatttccctaaaagttgcaaaccataatttcatttgtcaagtaaacatagccaa
tacattaaatgccattgctgttagattctatatatactttattttatgatgagttataaa
tatataaatacttaaannataaagctatcaaaaactcataaattaaaatattcagctcga
acactttgaatatttctctctcatgatcgtctttagcctttccaagaagttttccaacgt
actctggttggcttccttcacaggacaggaattctgcaaaanaaacatttcattagcttg
cattggtaagcatttgtcttgcctgcctgtctacttgatcaagcctactgtggcacttgt
cacctgaacacttataaaaccaaggcctccagtctagcctgactgggagttgtctctatc
actaggccagcaggttttgcctattttgggtgcatactac
>IGR1013a
acaggacaggaattctgcaaaanaaacatttcattagcttgcattggtaagcatttgtct
tgcctgcctgtctacttgatcaagcctactgtggcacttgtcacctgaacacttataaaa
ccaaggcctccagtctagcctgactgggagttgtctctatcactaggccagcaggttttg
cctattttgggtgcatactacttacacttctagaaatggttactgtataccattacctat
ctgcttttggggtgggtggcgcgggggggagtgcagtctctggagaggtgtgtcacagct
aggtgcttgctcagagggtggaacttgaagatgctggctcagacctgcccggtgctctac
tgggccttctgcatgactgcctggactgctgagagagattcagtcatgtggccctcctgt
gccattaaacagcagcaccgcagcacagcagccctaaaggtgggaaggattccagatgct
acccccaggccactgcttcagtttgaatctcagctctaccatttattaattgtattgctt
aggatgtactacttaatttataaaagcttcagtttcttttgtaaagttgggacaattgtt
tgcctacttgcctgcttcataagataatggagagaattaaaagagagaacatgtgttgtg
ccaagttcctatcccatgacctatcccattgtctacaagg
>IGR1014a
agtttgaatctcagctctaccatttattaattgtattgcttaggatgtactacttaattt
ataaaagcttcagtttcttttgtaaagttgggacaattgtttgcctacttgcctgcttca
taagataatggagagaattaaaagagagaacatgtgttgtgccaagttcctatcccatga
cctatcccattgtctacaaggtgataggcccagagaggggatacatgtccttgttctcct
ctaaagccaattaattcctccactcgatattagataacatccactctgggctacaaggac
ttctgccccctaatgattcttcctctttctgctctcttcagttcttcctgctccactgga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-181
ccattcccccaggtgcattaacatgctgggtatacccccaaccttaaaagagcttccctc
actccataaccaccctgcagctgtgggtcagtttctctgcagccttatagctaaacatct
tcaaagagtgttctgccctcactgttccttctttgtctcctctcgccaccctatcctcgg
tgagcccactccagctgggctttccttcctgcctctccatttacatcagcctcacccatg
gcctccatcagccaaacccaggggcctttcttggtcctcacctgacctgtcctttcagta
catttgacacagtcaaccctccctccttgagtgtcctcaa
>IGR101 Sa
cactgttccttctttgtctcctctcgccaccctatcctcggtgagcccactccagctggg
ctttccttcctgcctctccatttacatcagcctcacccatggcctccatcagccaaaccc
aggggcctttcttggtcctcacctgacctgtcctttcagtacatttgacacagtcaaccc
tccctccttgagtgtcctcaacggcttcctggggtaccgcccactctccagtgttctcct
gcctcactggtcactcctcctcaggccccttggctggatcctcctctcctgacctccatg
tgttgatctcaggctcagtcctttgatctctccctttctgtcattcagattttcagcagt
atctatctaaggactctcctttttgtattgcaagttctgacctctcccctaagttccaga
cttttctaaccatcttctcaacaccttcacttggctatccaagagccaccttacatgtac
gatgtacaaaattgaactcttgatcttctgctgaacctccagccctgccttgccgccagt
ctttcatctctctgtaaacagtactgaccatcgccagaggggtttgggcaggaacaaaga
ggtcatcttttcctcccctgtatcttaccccctacaaccgatctgtcagcaaatccttct
ggttttatttttagtcatatcccaaatctgttcacctcaa
>IGR1016a
ttgatcttctgctgaacctccagccctgccttgccgccagtctttcatctctctgtaaac
agtactgaccatcgccagaggggtttgggcaggaacaaagaggtcatcttttcctcccct
gtatcttaccccctacaaccgatctgtcagcaaatccttctggttttatttttagtcata
tcccaaatctgttcacctcaactgctcccattctgtccacgccaccatcatctctagcct
ggtttactgtggtagcctcccaacaggccatcttgcttcattctgtccacgccaccatcg
tctctagcctggtttactgtggtagcctcccaacaggccatcttgcttcattctgtccac
gccaccatcatctctagcctggtttactgtggtagcctcccaacaggccatcttgcttct
atgctttccccctttcagcctatttaccacacagtagccagactgacccttttaaatcac
gtaaatcagattgtacagtctttgtcctgcccaaagctctgcaggtgttccctgccatac
tcgtggtggaatctaaaggccttgtgtgatctgctgtcctggaaactacccctcactcac
tctgatccagccacactggccttcctactggtctttaaatacaggaagttagttcatttc
catcctaaggcctttgcatacctcctccttctgcctggaa
>IGR1017a
ctttgtcctgcccaaagctctgcaggtgttccctgccatactcgtggtggaatctaaagg
ccttgtgtgatctgctgtcctggaaactacccctcactcactctgatccagccacactgg
ccttcctactggtctttaaatacaggaagttagttcatttccatcctaaggcctttgcat
acctcctccttctgcctggaatggtctccctagttagtcatgtggcctgctccctcaatt
caaatatctgctcagataatgtcaccagctcctaagtcagccccctcccccatgactctt
atgttctttatttctatgtttttctttgtagcacgtatcactgctggccatcattttaca
tgtttgtttttctaactctcccattagaacattccatgagaacagggactcggcctgcgt
gtctttagtgacacgtcctcagcacctagaaccacacccagcacttgtggaacttcagca
aatacttattgaatgagtgaatgaatgaatgggttgaccaagggtgctgcagctcccaag
gagtgtttagaagtgaggctgctgtccaccaggagccacgcggccggcttgccaggaata
cagtgcagcttaccaagcccgccaggccccagaggttcctgtcgagccgtttcaggaatc
ggatcagctgcttgtgcctgtggaactgctgtgcagtcgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-182
>IGR1018a
aatgaatgaatgggttgaccaagggtgctgcagctcccaaggagtgtttagaagtgaggc
tgctgtccaccaggagccacgcggccggcttgccaggaatacagtgcagcttaccaagcc
cgccaggccccagaggttcctgtcgagccgtttcaggaatcggatcagctgcttgtgcct
gtggaactgctgtgcagtcgcacccaggcagcgagtgtccttctcatggtggctgtagaa
ctgccggagcacagtcgcagccctgcagaaggtttccttctcagttgtgttctggaaaga
caaatgccacagatagcaatgtgccagctccatttggaggatgggagagagatttttcct
cttgatttcttctttccaggaggacaaatggaggtgagtttgctcaactacagacctgtc
ttcaagtattccactgaaggaaggctgcttgccacagacataaacctctgtcaacaacct
ctcccaattgcaaacgcagcagccttctccccagaacctcccagtttcctttctcttgga
ggattttgccgaaagggtacctgaataaagtcatcccatgaggaaaaggcacagtgggga
ctagaatgcaggaccatctgtcgctacagcccacgttctgcgtccgtgtctctatacctc
atgagctattctgctatgaaaagtgcccacatgagctctc
>IGR1019a
cagccttctccccagaacctcccagtttcctttctcttggaggattttgccgaaagggta
cctgaataaagtcatcccatgaggaaaaggcacagtggggactagaatgcaggaccatct
gtcgctacagcccacgttctgcgtccgtgtctctatacctcatgagctattctgctatga
aaagtgcccacatgagctctcagtcaggttctgctcttgttcccagaggttttaaaatcc
agctttccctggaaatcctgcatgcctgttgaataaatgagtgcacatcctttggcctga
actctgctgctttggccagcactctccgtgtggctctccccatgggagaggagagcagca
catggcccaagtgaggagctaagacattttgccaggcagcaagagataagtgcacagatc
agggaaaggtgtcctgggagatcagaggaggctctgggagcaggtgccattgatctgagc
cttgggcagagcttctgtaaggggccttttggccccaaatgatgcggagtgagaatctcc
ttggaatgccagcaactgtgagggtctggccacatggctcttcctgggggcccttagcct
tagagaagggaatggacaagagacaagtcattgggaacccaggagagggattgtgtctca
gtctgaacctggcctggtgtgtcctctcatttttcactga
>IGR 1020a
aggggccttttggccccaaatgatgcggagtgagaatctccttggaatgccagcaactgt
gagggtctggccacatggctcttcctgggggcccttagccttagagaagggaatggacaa
gagacaagtcattgggaacccaggagagggattgtgtctcagtctgaacctggcctggtg
tgtcctctcatttttcactgaagaacaaagatgcagaacctggagagggttcttagcttg
agcccagttcctttatccagttcagataaagaaagctatccccagcctctcccccgacat
gctctggtcccttgatactcaaagtgtggtccatggaccagcagcatggacatcactggg
agcttcttagaaatacagaatctcagaccacccctgccccacccagaccctctgaatcag
aagaacagtgacaagatgctcaggggtttctatcagcagcgctgtccaagcagctttcaa
gttcttacatatttttttttctgatgatcaagataacatatatttactataaaggtaaca
tatattcaacaaaaatacattcactcatcccaccagccagaggtaactattgctgttaat
attttggtaaatatcgtcacacttttaaaaatactttttaaaataggggtcaactgttga
tactgttttgtaacttctttactctttacatataccataa
>IGR1021 a
tctgatgatcaagataacatatatttactataaaggtaacatatattcaacaaaaataca
ttcactcatcccaccagccagaggtaactattgctgttaatattttggtaaatatcgtca
cacttttaaaaatactttttaaaataggggtcaactgttgatactgttttgtaacttctt
tactctttacatataccataagcatttcctaagcccttcggtggtattagagaacatggg
attgagagctgcgtagaaacgcattgcacagtggtactgtcatttgtcaggcccctatcg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-183
tggcagatttttgcttctgtaaataagcggcagtgagtaaactatagaaatctttgtgtt
catctcttatttatgtaggctaaattctaggaatgcagttcatattttaacgttttttca
ggaaagtctagacccagactgaggcaccagaatcccaggctacagaagcttcccctttcc
cctgtggggcgtgatgtcccatgggcagagcggttagaaagacatttacttaatgaactg
actgagagtcactcctcgttcctgattctagttggaaatgtaagagtgtgtcagtatctt
tgggctctgggggccaagaaacagacctctctgggctttgtaggcgagtcgaggtggaag
ggacacgggctgatggggggcggcagatggtgcctgtgtg
>IGR 1022a
catgggcagagcggttagaaagacatttacttaatgaactgactgagagtcactcctcgt
tcctgattctagttggaaatgtaagagtgtgtcagtatctttgggctctgggggccaaga
aacagacctctctgggctttgtaggcgagtcgaggtggaagggacacgggctgatggggg
gcggcagatggtgcctgtgtgtctggaggtgggcagacatgcatgctgctgcagagggaa
cagtgagattcaagaaaaccaaaaagtcagccctttgcttcttttaccacaaaccttggt
gagatttttctgaaacgctggcttggagcctggaaattaaacttaattttgacccgtata
tggccacatagtataggaaaaaaccctctaaagatatttttgaaaggactttctaaagga
aacaaggataaaataagaattgaaaagagtctgcattaaatggaaaaactttaaaagaat
gcatcctaagggcagctttagtgcaaggccttaacgttttagttgctctggtatcgcagc
gagggggcgacactccatccctgccgtggccctggactcctaccacctgcctgtctagct
ctggctgctgagtgtgtctgccagtggctcagggagtgcacttggacagcctggctgacc
tcacagttcagaactgcttagggagtgactcagaaggagg
>IGRl 023a
agtgcaaggccttaacgttttagttgctctggtatcgcagcgagggggcgacactccatc
cctgccgtggccctggactcctaccacctgcctgtctagctctggctgctgagtgtgtct
gccagtggctcagggagtgcacttggacagcctggctgacctcacagttcagaactgctt
agggagtgactcagaaggaggcctgtccctcccgggaatgtcaggaaacagccacttggg
agatttcttctgtggcagtgactctgtgagagttctaactcggttcttgaccagcctcac
tgaggaccatataaatccagcccgattggcactgcattcattatctcccatcctgcccag
gatagtcagctagtgctgtatatgagaaactccttcaaaaaacagaggtatttgaggttc
attatggaactctctgtagaattatgaactttagctctctttggtaaataggaaatngct
ccaactacttgtccacccaagaaacccttcatcagccagccagcttgcttcttcccactt
tgctgttcctcagacagccttgacttcatagacaccctgacaggtgttacctgtgaagcc
caggacctagaccagtgccttctttccagcaactgccaagagtagaatgctacccaactt
agagatactaaaattcttgttcccccgaagaaataaaatc
>IGR 1024a
agaaacccttcatcagccagccagcttgcttcttcccactttgctgttcctcagacagcc
ttgacttcatagacaccctgacaggtgttacctgtgaagcccaggacctagaccagtgcc
ttctttccagcaactgccaagagtagaatgctacccaacttagagatactaaaattcttg
ttcccccgaagaaataaaatcaataggctggattttggaaagatgttttctttgggaaca
caaagaagtaccttttcctctgcataccacctttgtaggtttttgaaaatagcaacattt
cactgttctgaaatatcttaacatgtaagtaagcagtgctgaatcttcgaggggaagaaa
agagtgaagagtgagatcgtgaactccaggaggatgaagttcaggggaggcaaatgagac
gggtaagagtgaaggcaggcagtggggattattctaggagatgtttgtgtgtgtgagagg
gaggtgagtgaggactgagtgaagaggggagttaaggacgggagggcagcagtgtcctgg
cctgcacccgggggtcttccagaaacagcccagatggattgccccagactcggcatcctg
gatggtttgatcctttccaacccggtcccctccttcttagaatcatcgcttctctgcacc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-184
tgttcttgcttttaatcgtggttatatcatctcacaataa
>IGR1025a
tgaagaggggagttaaggacgggagggcagcagtgtcctggcctgcacccgggggtcttc
cagaaacagcccagatggattgccccagactcggcatcctggatggtttgatcctttcca
acccggtcccctccttcttagaatcatcgcttctctgcacctgttcttgcttttaatcgt
ggttatatcatctcacaataacactttgcactaactcaagagctggattccaatcaacct
tgcaatcaccttcagaatcactttcatatcttcacatgtggaaactgaggtgcagagagg
tgtgaagatgtgctgaaggccagccacacagctagtcagtggcagagctgggtctaaaac
cacaggcagtcttacctccaggccctcagccctcacccttcctccaggcctggcttctag
tgaggtggcccttcccttggctttgttagagccttctcagcagtgccacaggcctccaga
gacccagtgctcaacccggtggactcttggcttctagtaggagccatctcggttggatgg
acttggagattttatacacacacacacacacacacacacacanananatacanananata
natacanacananatatananacacacananananananacacacacacacacacacaca
cataaactgttgcccaggtgcagtggctaatcccagcact
>IGR1026a
tggactcttggcttctagtaggagccatctcggttggatggacttggagattttatacac
acacacacacacacacacacacanananatacanananatanatacanacananatatan
anacacacananananananacacacacacacacacacacacataaactgttgcccaggt
gcagtggctaatcccagcactttgagaggccgaggtggacggattgcttgagcccagaag
ttcgagacaagcctgggcaaaatggcaagactccatctctacaaaaaaatacaaaaatta
gccaggcgtggtggtgcacacctgtcgtcccggctacttgggaggctgaggtaggaagat
agcttgagcctgggaggtggaggctgctatgagctgaaatcgcaccactgcactccagcc
tgggtgacagaacaagaccctatctcaaaaaaaaaaaaaagtgtgtatttgcccttcaga
atctcatcctgtatcggactcccgggataactaatgaaatgagatagtccagctaaaggc
ccgaagagcagtttccctcatgaagcaggatgggccctgttctatggtctgggtgctgga
gtgtgaccctgcccaacacacagggcttcactcctggccatatcatctccctagtttgca
tggaaagcaggtagttaggagaccactgtgaaattgaggc
>IGR1027a
tcccgggataactaatgaaatgagatagtccagctaaaggcccgaagagcagtttccctc
atgaagcaggatgggccctgttctatggtctgggtgctggagtgtgaccctgcccaacac
acagggcttcactcctggccatatcatctccctagtttgcatggaaagcaggtagttagg
agaccactgtgaaattgaggctttggggctttcattctcagccgtgtgtttccatgaaaa
caggaactgaaatgcacaaaactattgatacggctgtagtcatgtgtttgtcagagaaaa
tgcactatcagctgtcaaatctatctcctcccactacagatagaggggtgggggtgaggc
agcacaggaggcagagaggcgaggtgcccaggcagcccgaagcagggatgtgctggacgc
tgcccagcaggatggttccagaccgagctggaggggagttcggccggccagagcaagctg
aggagctctggacggcgagccccggaacccagagggctgttaggtggccaggctgtggaa
gaggaggggctctggcgataccttttctgttgccataggaagtctcttagacaaaatgaa
agctccctcaacctgtcatctcaatatctgtttctgtgagagtatttggtttttcagaaa
tgtatgggccagaaaaattctctcattcaacaggcattta
>IGR1028a
ccccggaacccagagggctgttaggtggccaggctgtggaagaggaggggctctggcgat
accttttctgttgccataggaagtctcttagacaaaatgaaagctccctcaacctgtcat
ctcaatatctgtttctgtgagagtatttggtttttcagaaatgtatgggccagaaaaatt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-185-
ctctcattcaacaggcatttattgagtgcctcctacgttccaggcactatgccaaagcta
agtaaaacccaagagggcttttctttgaccaggatctgagtcaggactacagcatgtaag
ctttctattacatgtcttctaaatcaagtgaaaccagaaagaccaaaacatgcttaagag
taaagatcagacttctcgttctttgaaaacatctaacaccttagagttaatttgggcccg
ctcgttttccattagacaagtttcttgttcagacatttggggatggatcnccccatttgc
taaaacagaccgtgggacggcttcttaccttggaggcagcaaagatgtctgttacggtca
actcggtgcacagagtcttggtccaggcagaaatgagagagcaagagacagagttaacct
ccaaccggacagagaagtccttgatgagcagctctcactccctccaactgaggaaacttc
ctacaaaccctcagaaaaaagagtggcaggggagaagcct
>IGR1029a
gcttcttaccttggaggcagcaaagatgtctgttacggtcaactcggtgcacagagtctt
ggtccaggcagaaatgagagagcaagagacagagttaacctccaaccggacagagaagtc
cttgatgagcagctctcactccctccaactgaggaaacttcctacaaaccctcagaaaaa
agagtggcaggggagaagcctcgctgtgtgccctggactgccaccaaccaccagttccaa
cttctctagcagctgttaacgttttcatgcctagaaatactgagagcatcaccagaacat
ctggagagatggtgccagataggtactcaccttctgctctgtgaggctgttcaaagtttt
gatgatctcctgtaaggtgatatcgcacttgtgtccgtggacaaagttgccggcacatgc
tagcaggaagaacagagggggaagcagttgggaggngagacccattaataggtgtcgatt
tgcagtgacaatgtgagncaattagtttatcaggagaagctaacgatncaatgctgacaa
agatatctctatatatagatttaaaattgctgaaaccgagggaaaatgagtttacattgg
aaattttcgttacaccagattgtcagtcacttggggccaatcagcacctctcttccagga
gaaaaaatgcctcacaaacaggtaaaatgttcctgtgaaa
>IGR1030a
aattagtttatcaggagaagctaacgatncaatgctgacaaagatatctctatatataga
tttaaaattgctgaaaccgagggaaaatgagtttacattggaaattttcgttacaccaga
ttgtcagtcacttggggccaatcagcacctctcttccaggagaaaaaatgcctcacaaac
aggtaaaatgttcctgtgaaatcagaccaataggaaaatgaaacctttttaaaaaattaa
ctacaaagtttcagcataggaaattacaccataatttgctctttagattaatcttatcag
cttggggctgctgctggctttttgctttgcatagaagggagaggccacaggtgtccgaat
ttgttgtaatgcagtcctcctggggaaagatagagtaatatcaagaaagttttacttgaa
aagtattttaacctggcttcttccaagtacaggtggcatcttggaaactgtcctgtcatg
gaaaagctgatctggggctccttctctgcatagaggcagaataacaggcagactctccta
ccccagcactggggnacaatgttctcccaagtttaggtgttttgagaaggacaggtcgta
tcaggtgaggcctagtttgggtcccagcaggtccataaggtccttacccataaggaagcc
cttggcaaggtaggtctattctgaggtttcaggaatgact
>IGR1031a
ccttctctgcatagaggcagaataacaggcagactctcctaccccagcactggggnacaa
tgttctcccaagtttaggtgttttgagaaggacaggtcgtatcaggtgaggcctagtttg
ggtcccagcaggtccataaggtccttacccataaggaagcccttggcaaggtaggtctat
tctgaggtttcaggaatgacttttttttttttttttctgagacagggtctcactctgtca
cccaggctgaaatgcaatgttgtgatcagggatcactgcagcctcaacctcccaggctca
agtgatcctcccacctcagcccccctagcagtaggtgcgtgccaccgcaccatgcctggc
tcatttttatttttattttttgatagagataagagtctcactatgttgcctaggctcatc
tcaaattcctgggctcaagtgatcctcctacctcagtctcccaaagctctgagattacag
gtgtgagccaccatgcctggccaggaatgcccactttttgaatggaacctaaacacatcc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-186-
tcagctaattaggaaaaagagctacagtcttaccaacttacaaatcagccctcctagtca
gtgccccaccacccgccctgcttgttttttattgaattcatgtggacacaataaggtgct
cattgcctcaccccagcagtgaacgtaaggaccccaccac
>IGR1032a
gccaggaatgcccactttttgaatggaacctaaacacatcctcagctaattaggaaaaag
agctacagtcttaccaacttacaaatcagccctcctagtcagtgccccaccacccgccct
gcttgttttttattgaattcatgtggacacaataaggtgctcattgcctcaccccagcag
tgaacgtaaggaccccaccactcactcaggtgcctgggccctgtgcaaggccaccccacc
tcccagtaagggctcatgggcagcaggattcttgggccctgcctgccccctgcttttctc
ccagaaccttcccttcccttggtctctgaccttcttttccctatgaatttcttttttttt
tttttttttttgagatggaatcttgctctgtcacccaggctggagtgcagtggcgtgatc
ttagttcactgcaagctccgcctcctgggttcatgccgttctcctgcctcagcctccccg
agtagctgggactacaggcacctgccaccacgcccggctaattttttgtatttttagtag
agacggggtttcaccgtgttagccaggatggtctccatctcctgacctcgtgatccgcct
gcctcggcctcccaaagtgctgggattacaggcgtgagccactgtgcctgggcctcccta
tgaatttattctggaagatcatctaaaaatgtgtgttgct
>IGR1033a
acctgccaccacgcccggctaattttttgtatttttagtagagacggggtttcaccgtgt
tagccaggatggtctccatctcctgacctcgtgatccgcctgcctcggcctcccaaagtg
ctgggattacaggcgtgagccactgtgcctgggcctccctatgaatttattctggaagat
catctaaaaatgtgtgttgctaaggttttgcctctgttccacttccccgcccccccctca
ccaccccctgcccccatactctgtcacccaggctggagtgcagtggtgatcatagcttac
tgtagccttgatctcctgggctcaaggcattctccagcctcagcttcccgagtagctggg
attacaggcacatgccaccacgcctggctaatttctgtattttttttttttttttagtag
agatggggtttcaccatgttggctaggctggtgtcgaactcctggcctcaaaatgatcca
cccacctcagcctcccaaagtgctgggattataggcgtgaaccaccatgcccggccaagg
ttttgcctctgttttggatcttttcttcccttattattattattattaaattgacaaata
agtattgcacatatttgtgctgtatgatataatgttttgaaatgtgcatgttatggaatt
gctacatcaagctacttatacaatacttcacatatttatt
>IGR1034a
gtgctgggattataggcgtgaaccaccatgcccggccaaggttttgcctctgttttggat
cttttcttcccttattattattattattaaattgacaaataagtattgcacatatttgtg
ctgtatgatataatgttttgaaatgtgcatgttatggaattgctacatcaagctacttat
acaatacttcacatatttatttttggtaagaacatttaaaatctactctgtgatttattt
atttattttgagatagagtcttgctctgttgcccagactggagtgcaatggcgcagtctc
agctcactgcaacctctgcctcctgagctcaagcaattctcctgcctcagcctcccgagt
agctgggattacaggtgcctgccaccacgcccagctaatttttgtatttttaatagagac
agggttttaccatgttggccaggctggtctcgaactcctgacctcaggtgatctacccac
ctcagcccctgcaaagtgctgggattacaggtgtgagccactgcgcctggcctgtcttca
tgatttttaagtatacaagacattgatatcaactgttgtcaccatgtcgtacaatggctc
tctttaacttaactcctcccagttgaaattttatatcctttgaccaacatcttcctgatc
accaccctcccagcccctggtgaccatcatcctactctct
>IGR1035a
tgggattacaggtgtgagccactgcgcctggcctgtcttcatgatttttaagtatacaag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-187-
acattgatatcaactgttgtcaccatgtcgtacaatggctctctttaacttaactcctcc
cagttgaaattttatatcctttgaccaacatcttcctgatcaccaccctcccagcccctg
gtgaccatcatcctactctctgcctccctgagtttggcttttttatatttcacatatgcg
tgagatcatgtggtatttgtctgtctgtgcctggattttttcacttagcataatgtcctc
caggttcatccatgttgtggtgaatgacagcgtttccttcttttttaaggctgtatagta
ttccactgtctatatatagttttggatcttatcgcagtgcctcaagttctgtgaaggaga
gaatctggataattgtatcaggaggtccttagaccatatttaggatccttccattgggac
tgggcagcaaggttaccaaactaaatgcagtggcttcagatgccaaaccacctgagatga
gccacacctcacaggtgaggggtatggtcccccacaacactgcccttgcttcagacgcca
gctgcacattcaggggttcccagcccaccctcactgctgactggctgcaaatctgggagt
ttccactacccctcaggttccagaatgcactaggatgact
>IGR1036a
actaaatgcagtggcttcagatgccaaaccacctgagatgagccacacctcacaggtgag
gggtatggtcccccacaacactgcccttgcttcagacgccagctgcacattcaggggttc
ccagcccaccctcactgctgactggctgcaaatctgggagtttccactacccctcaggtt
ccagaatgcactaggatgactgacagaactcaggagagtgctatacgtaaggccacagtt
ttatcataacaaaagcattcaaatcagaaccagccaaaagaggagacacaggggcgagat
ggaggaggggcccaaacacaaagctctcattgtcttccccgtgtggcgtcagaggcatca
ccttctcagcactttgacgtgtgacaaaatgctgactatttctaagcagggaggctcact
tgagctttggggtccagagtttttatttgagtcttatcatataggtgtggttgatggact
cattggccactgggttgaactcatcttcctggtctccttccgggaggccaggctgatatc
acagaacctcagtggcgtggccagcccctccatggtcgtattgtcagcaaaaactaccta
gggcccaccatgagtcacttcactcgcataaactctcagagaccaccatgaataataaga
tactcctatcacttgggaaatccctaggaatttggggcta
>IGR1037a
ctcatcttcctggtctccttccgggaggccaggctgatatcacagaacctcagtggcgtg
gccagcccctccatggtcgtattgtcagcaaaaactacctagggcccaccatgagtcact
tcactcgcataaactctcagagaccaccatgaataataagatactcctatcacttgggaa
atccctaggaatttggggctacctcctgggaactggtgacaaggactagccacgttgttt
actccaagggtttgtagctggtaggacctcccaagagccaggacaaaggccagacttctt
ggataaaggttgattcttcactgcacaaactggaggagagttatgagaagagcaggtggt
tgcttccaaagcaggtggggactttggatccgatgaactattatgtggaatgaagtacag
cagcggttccagttaacacaggagggagctcatcaagctgcggacttgctgggtggagag
cttctgccaaataggttctcaaggagagtcggggatgcagaaggggagctggtggggagg
gcggggttctggggcgtctgtgggggcagtggaacagccatttatgtgtccatctggtgt
ttttctaagcacccactaaagggcagaccctgggcttgaggctctgagggcagagctggt
gagtgaaaagggaatattaggtgggcaccttcagctcaga
>IGRl 038a
caaggagagtcggggatgcagaaggggagctggtggggagggcggggttctggggcgtct
gtgggggcagtggaacagccatttatgtgtccatctggtgtttttctaagcacccactaa
agggcagaccctgggcttgaggctctgagggcagagctggtgagtgaaaagggaatatta
ggtgggcaccttcagctcagaagcagaatccagcttgttttgtttgtttcaatggtgaaa
tgaggccaaagatgaaaggataaactgtccagaacattcgagagtgaccaggagtctccc
cagagggcagaagtgggggatgggccatcctcgcctgcagggacagcaccatggcagctg
caggtgcggcaggtgggtagagatggggaaggtgggtgcctgcattgtcagggacaaaga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-188
ggagggcagtgatcaccaccactaccaccactgcgaaggagtctccgagcctgcagggcc
atgggcagtgccttggcggggtgtggtgggcctgacaccaaagttcaggagggaggttga
atactgctgtctctggctgtgtcggtcacaggccccttcccctcccctgtgtgagagctg
agaaccagcgccggcccctccatggatgcagagtttttccttcaggccctggaacgtagc
agttatgagcactgcgtttgggagtccagcaaatgagccc
>IGR1039a
ggtgtggtgggcctgacaccaaagttcaggagggaggttgaatactgctgtctctggctg
tgtcggtcacaggccccttcccctcccctgtgtgagagctgagaaccagcgccggcccct
ccatggatgcagagtttttccttcaggccctggaacgtagcagttatgagcactgcgttt
gggagtccagcaaatgagcccttatcaactctgtgaccatgagtagatcattaactctct
ctgggtctcgattttctcacctgtgaaatgggaataatgtggctcttccttgtgaggagc
aagtgagtggttccatggaaagtacttggcatgtgtcatccagaaagggggtctgttaac
agaggctgctatagtacacggtggctaagagagcggacgctgggcccaggtggtctgtca
ggcctggctgctgtgcctcctggctgtgtgaccttgggcacgctactcagcctcatctgt
gaaataggggtcatagctgtccctgtctcatgaagttgctctgaggaatgaatacattta
aagttttcaagtatttagaatagtgcctggcacacagtgagtgtgatgatgataatgatg
actcctatcttgagttgctgaaatgactgatgcttcatctattaggcaagcccaagtctg
gacagggcagtggagatctggccagacgggccctccccac
>IGR 1040a
tccctgtctcatgaagttgctctgaggaatgaatacatttaaagttttcaagtatttaga
atagtgcctggcacacagtgagtgtgatgatgataatgatgactcctatcttgagttgct
gaaatgactgatgcttcatctattaggcaagcccaagtctggacagggcagtggagatct
ggccagacgggccctccccacaggttcctcctggatgtgcctcctccgtctttgagttgc
cgtccttgtttctggtgggtcacggtctccacactgcagcccgcctactttagtatctgg
attcattacagggaacagacacagctgtgggtgctttagtcaggaaaggatttcatgcag
gaaagtaggtgcttctaagaatgtcaggagggctggaggggcaggctccaggctgggccc
agaaccctaaagacctgacccactcagcgagccacccctgaggctgcagtgccgggattc
caaagctgctgcctctgctgaccccctacactgtgagtctgctccaggagactcccggtc
tgacttccacaccatgagtctgctcaaggacacccctagtctgaatgaccaggtacatgg
tatctgccgccctcccctccacagcttgtcagccttcatctaattggaaaagccagatgc
tcgcttcaaaggagtcagaaacgcggcagtcaactaggag
>IGR1041 a
gaccccctacactgtgagtctgctccaggagactcccggtctgacttccacaccatgagt
ctgctcaaggacacccctagtctgaatgaccaggtacatggtatctgccgccctcccctc
cacagcttgtcagccttcatctaattggaaaagccagatgctcgcttcaaaggagtcaga
aacgcggcagtcaactaggagaaaggaatacaggtcgcacaatgcagcccagtctccacg
ggcctcgttcattgatgcttgctgtcccagccattcctgtggtccgagtcgggtgaatct
cacctccctcctcttctgtcagtcctgcaggccagcacccaggagagtgctttccaaccc
ccacaggcttagtcatggaaaaaggtgagacttctctgagggaggggcacttaagcagag
ttagggatgagccggctttagccaggagcaggggctgcagggtggggtgagtgcgggcaa
gggacagcaggtggaaggccccgaggtcactgaagagagggctcccaggaggggagcacg
ggccgaggggacccagccagagcattgcaggcgcccgtgacagaggcagctggcgcgaat
cgggtgggatggtggcagggagagctgtgggctcttgagtcatttggcccagcacagtgt
ctaggttaagacctggtgtcttggtgcccacgggacctga
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-189
>IGR1042a
cccgaggtcactgaagagagggctcccaggaggggagcacgggccgaggggacccagcca
gagcattgcaggcgcccgtgacagaggcagctggcgcgaatcgggtgggatggtggcagg
gagagctgtgggctcttgagtcatttggcccagcacagtgtctaggttaagacctggtgt
cttggtgcccacgggacctgactggttctgaatcccagctctgggtgaccttggaaaagt
tcccccatccaggcttctctgtaaaactgggctgattacaggggcgagggaatactatag
aaggtgacaaatatgaagtgtttggtgtggtgaccggcatattgcaagcccccggaaaat
gccagcaatcaccatcaccaccaccatcatcattaatagcacttggaagtgactgaatgt
gggggtgagggagagcaggaagtcgcaggtggccccaggtctctggcttggggaggaggc
aggggagagggcaggcggcgggtggnagccaccagctgaggggctgctacgggccatact
ctgagaacaggggagggtccagcctgcaggcagtagacatggagggtgactaagccaagg
ggaagaacacagtgttgctggaaaaaggggtcccgattcagaccccgagagagttcttgg
atctcgcacgggaaggaattcaaggtgagtcgtggtgtgt
>IGR1043a
gggtggnagccaccagctgaggggctgctacgggccatactctgagaacaggggagggtc
cagcctgcaggcagtagacatggagggtgactaagccaaggggaagaacacagtgttgct
ggaaaaaggggtcccgattcagaccccgagagagttcttggatctcgcacgggaaggaat
tcaaggtgagtcgtggtgtgtggtaaagaaaggatgtagaaaactactcagagtagggtg
tcctcagaaagcatgagcaggaacgccttgtctgcttaaagcttttcttatataggggtc
ttgtctatacaaaagccaagctacattatgtctatgtgcaggtgggctgacagtgtcaca
aaatttagtactttgttgatttaaataatgttttatccttggccttttagtgagtaagta
catcaaagcattactgtaaatagcttgaaagcatatattgttatgagacatcaggacacc
cagacattctgctgttgtaggagtttgtccttgcgggcgtgactaaactgcttccttggc
gtaaacatctcatgaccatgggtagtgactggcaaggaatatgcctagctagttttaaga
tggagttgattttaaaatggtgtcaccctggctctcctccactcctgttgacctaacaat
atggccaaggggtgagagaagacaggggacaagaaatgag
>IGR 1044a
ggagtttgtccttgcgggcgtgactaaactgcttccttggcgtaaacatctcatgaccat
gggtagtgactggcaaggaatatgcctagctagttttaagatggagttgattttaaaatg
gtgtcaccctggctctcctccactcctgttgacctaacaatatggccaaggggtgagaga
agacaggggacaagaaatgagccagggcactcctgcgacactggaaggtggtgaggcagg
gtgcagagtccaggcatgagagaggcccagggaggaggagcagtggtcagcggcagcaat
gttcctcgtaggtgaggctagataagggcagacatgcgttgctgcacggagtggagttga
taatcagtgacctcatgagatatctgagtgcagttgggggcacaggaagtggccagatga
ggtggaactcagtatgggcatctgggagggcagctgtgttgggctgcaggctgcgtcgta
ggttgtcagctgtgttctgaatgggacacaatcaagcacaggctgccccagctcagcgag
cggcagcttcatccttgcagttgttcacacacaacacgggaagacctcacacgctcatat
ccaagccaccccaaagcctctcctttcactgatgtgacatctcggattggtggtggtggg
gaaggggcgggggtagagatggaacaaaattgacaaaact
>IGR 1045 a
aatgggacacaatcaagcacaggctgccccagctcagcgagcggcagcttcatccttgca
gttgttcacacacaacacgggaagacctcacacgctcatatccaagccaccccaaagcct
ctcctttcactgatgtgacatctcggattggtggtggtggggaaggggcgggggtagaga
tggaacaaaattgacaaaactggccatgagttgctcattgttgacgctgggcaatggatg
cttgggagtgactttcgtgtatatttgaaattttctgtaatagaagattttaaaattgta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-190
attgcatagcaaatgtaaatattaacatatatgcacatttatatattatatatttanatc
tatactttatggattatataatatactatttaagtaaataatgtatacgatagcagtata
atgtatacatgcatcttacacacacgcccctctccagtcctccactaccacaagcaccat
cgctccccaccagcatctctgcaggcaccttggcgctcatctccctgctccgccttcgcc
ctgcgttgcgttctccacacagcagccacggtgactttgttaaaatgtgagtcagaccac
atcactccattccacttagaatgaagcccggtcctggcctctgaggccctgctgggntcc
tgctgcccttgccgtggcctctgctccagcccgagggcca
>IGR 1046a
tgcaggcaccttggcgctcatctccctgctccgccttcgccctgcgttgcgttctccaca
cagcagccacggtgactttgttaaaatgtgagtcagaccacatcactccattccacttag
aatgaagcccggtcctggcctctgaggccctgctgggntcctgctgcccttgccgtggcc
tctgctccagcccgagggccacccgtgagtgctgggaagggcatccccagctcgctcttg
ctcaagaccttagcacctgcagttccctttcccttgatgactttgccccgatctgtgcat
gggngtcccctnccccttgtttcgtcccgatctctgttcccatcttatctcatggggagg
atttctccaacctcctcgcataacacagcactctccctgctgtgcagccccggactgttc
tatttcccacggtagcggctaccaccgcccgacacactgagtgttctctcgttggcttat
tctgtctccctgctagaagcaaccttgttttgtttagtggacccccagcacctagagcag
ggtctggcacccaggcaaggcctcaatccatacttgttgaatgaatgagtggagctccat
ttccacggagccactgagacgtggctgaagtaacaacactagaagtcagggacacagctg
gggcttgaagctgggactagtttcaccctgagcccccggc
>IGR1047a
caaccttgttttgtttagtggacccccagcacctagagcagggtctggcacccaggcaag
gcctcaatccatacttgttgaatgaatgagtggagctccatttccacggagccactgaga
cgtggctgaagtaacaacactagaagtcagggacacagctggggcttgaagctgggacta
gtttcaccctgagcccccggctatatgctctgcctgtgttcctgagaggggaggggatgg
ggcccagagcacanacacatggagggccccatccaagggcacagggaccgaggggaggag
agaaacgaggctggcaggcagtggcatagactccgctttgcggagctgtggggaagtagc
tctgcaggctgttggcttctcttgcctttcagaagcaggtggaaggtccttctcccaaga
gaggcagagctgctgaggagtctgcaggaatgctccatctgtccccatagtgttaatgtc
acttcagcctcagagctagatgggcggcctaccctttcccttcccactcccgctggctcc
tgtgccctggcaggccagggcctagtgaagacccccaagaaggcagcaccttcctctgtc
tttggcaatgtgggatctgatgggtccaagagtgcccaacccatgggaggagcggtgcta
gtcctgtctggctgaggggctgccttgcaggcccctgcag
>IGR1048a
atgggcggcctaccctttcccttcccactcccgctggctcctgtgccctggcaggccagg
gcctagtgaagacccccaagaaggcagcaccttcctctgtctttggcaatgtgggatctg
atgggtccaagagtgcccaacccatgggaggagcggtgctagtcctgtctggctgagggg
ctgccttgcaggcccctgcagacccccacctcctctcccgagagggccggctccccaggg
aggacttaggctggtctgaggggtgctggtgctggtccagccgggggatgctgcaaccag
gtctcctcactggcctgtctcggtccacatcctccatggagcagacatcacgttcatgtt
ctttttgctttttaaaaatgaaatttatccttgtctcccattggaaaatgaatgcatgct
cattatagaaaatgtgggaaacagatcagaagaaagaagagtaaataaaaattgcctttt
ccaatgtggcatcaccacagctcctctggcacagggccctgggctgggcagggagttgtg
gactgtgtngccaacaggccatcgggctgtgggtctacaggggatgccatcggtggcttg
ggccttcctcccttgagggtttggggaaatggtgtccagcccccgcacagttgtccacag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-191
tgatgcagagagtggagctgacgagagttgctatatttaa
>IGR1049a
gctcctctggcacagggccctgggctgggcagggagttgtggactgtgtngccaacaggc
catcgggctgtgggtctacaggggatgccatcggtggcttgggccttcctcccttgaggg
tttggggaaatggtgtccagcccccgcacagttgtccacagtgatgcagagagtggagct
gacgagagttgctatatttaattttggtgcctgcgtcacctctgaccacacagcagcgtc
tgcccaggcaggcagcacatggctgggggtgtttctgaacgacgctgtgagagaatcact
ttccccaagaaaaggtatagcagaggggaagggagagacagcaacagaaagtgaggtcgt
aagtagaaaattgcttctgggatttcaaatggctttgtcatggggccctcccttnctgcc
gagaaatcagttgatctgggaaagtttgttgcaaacccttgccctcttgcttttgggtgg
agctgagaaatgaatgaagataatggggctttatgagtgtgggggagggtagctgaggag
acagccaccagtcctgaccccagcttggacccctagaaaggccagataggagctggccag
tgtgtccctggccaggctgtcctgtctggaacatagtcagcctgnccccagccggacctt
cttagaagggaggcaggcgaagtgggaaacaggtttggag
>IGR1050a
ataatggggctttatgagtgtgggggagggtagctgaggagacagccaccagtcctgacc
ccagcttggacccctagaaaggccagataggagctggccagtgtgtccctggccaggctg
tcctgtctggaacatagtcagcctgnccccagccggaccttcttagaagggaggcaggcg
aagtgggaaacaggtttggagtgtgttacaatgcaccagctagatgaagggcataggcag
aagacatttctctttgaccctaatgaaaaagcgataagccgctgggccaggtgaaggcca
ggcttcaagctgctgcctcggtcacaaggaaataagatgcgggcctggtccccttggggc
ctgctccttctcgtcctgcgcaggacagggggccagcctcggagaaacctgccaagtgac
tgggagcattttctgacacctcatctgagcagcaaactgaggtgtttggtgccgagttca
ccggaaactcgcgtgtgtctcacttctcactcaagcccagcctctcttccagtgaaacct
cctgggctggggttcccgaggtgccaaggggctccccgccctgggccccatggccagcat
cttcctcccactcaccaagcactcttctcccttctcaacccccttctctctgagtcctgc
tgagggcttgccttgtttatgaaagaacttaggccacgtg
>IGR1051 a
tcacttctcactcaagcccagcctctcttccagtgaaacctcctgggctggggttcccga
ggtgccaaggggctccccgccctgggccccatggccagcatcttcctcccactcaccaag
cactcttctcccttctcaacccccttctctctgagtcctgctgagggcttgccttgttta
tgaaagaacttaggccacgtggttagagaaaactcccagcaaacaccaccagggctcagt
ccccagggagggaggttcccagccacagttgcagtgctgacacttacctaccttgttctg
tcttcctttctcattcctgacagggccccttccctgtcgccaccagctgcagcttggttc
tgtggctcagtaaggtgtcactcatccctggagagccccacgccctctccagcccagggc
acactgccagtgaccacaggtcccccttcctggggagcagcctggaaggtgtgagggaca
ggagctcggcggtggctgaggaagtggcgagctgcagacccctagtggggcccgggacgg
ccatccgcactgtgcacctgcctcgcaggctgtcctgaatgtgtggctcagagcacggcc
ttggaggatcccgaggaaccttgccccacatcagcctcaattccagtctttgttcttgag
ggagtcacgtggaatttcactggaagggtttccatctttc
>IGR1052a
ggaagtggcgagctgcagacccctagtggggcccgggacggccatccgcactgtgcacct
gcctcgcaggctgtcctgaatgtgtggctcagagcacggccttggaggatcccgaggaac
cttgccccacatcagcctcaattccagtctttgttcttgagggagtcacgtggaatttca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-192
ctggaagggtttccatctttctggataggcagggcaatactttggctgggcagagaggac
atgggtcaaagatgatgctactgggagatagatttctaggtcttgtttacaaagtcatta
ccctccgtaaatatccttccagccttaaaccctaggctctggatggagaagaatgccgag
accctgactcccacccacctcccctggcttccaagactctctcgtcctttgcggaagcag
ccactgctcacctccagaggggaggccctcccgagggaggacatacagctcccccaaccc
gaccctctgttgtttctacagagttctttcaggggctaaatcttgagtgcatgtggtgtc
ttggttgtcactagcccaggtgtctgctgtggggtggtcccccgcaggtatttcctcagc
aaacgtggcaggacttaataggcttggcaccagagagccggtcctgtctcctgcccggga
cagcctgctggagacccagctcttgcaccatcaccctctt
>IGR1053a
agagttctttcaggggctaaatcttgagtgcatgtggtgtcttggttgtcactagcccag
gtgtctgctgtggggtggtcccccgcaggtatttcctcagcaaacgtggcaggacttaat
aggcttggcaccagagagccggtcctgtctcctgcccgggacagcctgctggagacccag
ctcttgcaccatcaccctcttcacccccacagtcttctctcctctaggccaagtgtcccc
tgccccctgcactgtcaggtttgccttcttccgtcgcctctccctggggaaagtgagtgg
ttctggagtagctggccaccatcatcagccccctggcgaactccctgccacgtcctctgc
tgttgcgtgaatgacacagccatgagcagtcgagggcggctgncttcagggacttctgag
catcactgtggtgttcccatagggctctgggctccccagggagggcacctgcctgtcact
acaagtttgagactggttcttgaagaccatcacccactgcaaaggcatcccatcctggag
tcaccctctgccctgggcacctcccagagagtcacagtgaaaagtgttgctgacgggcat
ggcctggagctgtggcttggtaaggcccgctggtctctgcactccagctgctgaccaggg
ccatggggaagcaacaagagctgctgaggagtggcctagc
>IGR1054a
ttgaagaccatcacccactgcaaaggcatcccatcctggagtcaccctctgccctgggca
cctcccagagagtcacagtgaaaagtgttgctgacgggcatggcctggagctgtggcttg
gtaaggcccgctggtctctgcactccagctgctgaccagggccatggggaagcaacaaga
gctgctgaggagtggcctagccagagccctgttcacagaggtggtgcgtgtgtgcaccct
aatggcgagagctgtccagaaatgcaatgggctgcccctcaaatataggtagggacctgc
ctgtcagtgagagggcccgaacaggttgatgacagttgtacagggggaaaaactccattc
aggacaggtgacatttgganagaaataggnagggtggttaagtgtgtgggctttggagtt
aaagtgaattttggaccccaatcccaactttgctcctttacctcagatgaggctctgagg
ccccaggaccccagtgaggaagtagctacgtgaccttaggcaaaccgcccacgctttctg
agcctcacagttctcatcggcctcctgggttgtgagggagacatggatgtgtgggtggtg
ccagacacagctggccagtcctcaggagatgtgattgtgagacttcctgggtctccgtct
gctcctgatgccctccttgaaccctgacagtctggcccaa
>IGR1055a
aagtagctacgtgaccttaggcaaaccgcccacgctttctgagcctcacagttctcatcg
gcctcctgggttgtgagggagacatggatgtgtgggtggtgccagacacagctggccagt
cctcaggagatgtgattgtgagacttcctgggtctccgtctgctcctgatgccctccttg
aaccctgacagtctggcccaagcctctccgtccttgctggtgcagcagacagaaggtggg
gcttccttcaggccatgtccccaccctcgggagctagcttgcattcagcccaggtcactg
caccctaccctcgctgtaatccatcccagtcccctcctccaacccaccagcctcccgaag
agctcctcagagtcttcagaccacagaccagtgtccccaaaggccaaaatgaaagacaaa
tacaatcaggcctatctgtcaccaactttatttctggcttcagtttgatagtcaatgaaa
caacttgttcaatgtcccctcccccagtgttcaaggtacccttctatatattaactcttt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-193
gctaacatatttaatatttaaatacnaggaaaaacaataaattactcgttggctgagagc
tggctgctggctggcagacaggagcggctgttctgcccctctcctgaccctgcctcggat
gaggctccgaggccccaggaccccagtgaggtagcagaat
>IGR1056a
tcccccagtgttcaaggtacccttctatatattaactctttgctaacatatttaatattt
aaatacnaggaaaaacaataaattactcgttggctgagagctggctgctggctggcagac
aggagcggctgttctgcccctctcctgaccctgcctcggatgaggctccgaggccccagg
accccagtgaggtagcagaattctgtacacagtacttattaccagggactcctggngtnc
actgctttagtgctgnggncctgagtctctgaacccttggctccaagtgcnagcagccac
agtcttccccaatccccaacggtgacaaacacactcatttaaataacacacaataataaa
taagaccaagaagaagtgtgcctgagctgctgtctgcctcagttgcctgtgtgtgaagtg
ggtccctgtcccaccacatgtctggcaaggggggcanccactgtaatgctacagtgtgct
ctagggcaggggaggggtgtagggacatgtcatccctgggtccaccgagctcagggccct
ggacagaggaggcccaccaggctgagccctgggcaaggggaaggctgaggtcggctaggc
tgaanacgggcagcacaggctgaggtctaagctaaggaattttacccctccctaaccctc
cttcccgcctacccaagacatttttgacatcagaaagaaa
>IGR1057a
tagggacatgtcatccctgggtccaccgagctcagggccctggacagaggaggcccacca
ggctgagccctgggcaaggggaaggctgaggtcggctaggctgaanacgggcagcacagg
ctgaggtctaagctaaggaattttacccctccctaaccctccttcccgcctacccaagac
atttttgacatcagaaagaaaaatgaatctgcaacttcaatagtcaggtcctgtctctgc
aaataatgatgctttcgaagtttcagttgaacngtccctcgcgaaaaagtttctttaaat
gtaagagcaggtcctttacaaactgggccacctcgattttggtgtctcgganatgcaagc
tggaaaactgctgcaggacaaagaggtcagcacntgagtagaannccagaggccgggacg
actcgcacaaaccaggggctttccagggactgtctcattcagtcctcacggaagtcccca
tgaggtgggtactgttagtacctctactgtacagatgtggaaattgaggcccaggtagga
gttaggagcccttgagcccagatcctgtaaatcccgaaggccacgtccctgctgccacaa
tggccccacccctgggtgnacacacaccatggatattcagccagcttcccttcagcgagc
ccagggttggcaggagggggtgcagggtgggtgtgagagg
>IGR1058a
acctctactgtacagatgtggaaattgaggcccaggtaggagttaggagcccttgagccc
agatcctgtaaatcccgaaggccacgtccctgctgccacaatggccccacccctgggtgn
acacacaccatggatattcagccagcttcccttcagcgagcccagggttggcaggagggg
gtgcagggtgggtgtgagagggtgggggatgccttaccccagctgagaccctgtgcgggc
agaatccgctcagcatcctctgggtcttctcgatggcactgcagcctgacacgttgatca
gggattccagggctgcacagtactgtggggaggggacaccgaggggtcaggccctgcttg
ggcagctgccttttgtgagtctgcaggaagatggggctgagatgcctggcgcaggtgagt
ctgggtggtgggcgggaaggggccagattatggcgggagggaggagancacttgaagctt
gcttggaaccccagccatggaagggaggctcagagaagataagcccaaggcctggagcct
ctgccccatcctccctgcacccaaaggtccttaccatgccagctgtcaggttgatgctcc
ataccatgctgccattgcagagcggancctnntgggagcaaagtgacagtgagcagagtg
ctggcaggggttgtgggcctgccctggcagcccaggccag
>IGR1059a
gaagggaggctcagagaagataagcccaaggcctggagcctctgccccatcctccctgca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-194
cccaaaggtccttaccatgccagctgtcaggttgatgctccataccatgctgccattgca
gagcggancctnntgggagcaaagtgacagtgagcagagtgctggcaggggttgtgggcc
tgccctggcagcccaggccaggtctgccccagcacaggncccacaagcatccctggtgtg
gcacagaggcaggcctggcancccctcancattcctgagcttcgttttctgctttgaaca
gcangcataggggtgaggtcccactgtttagggtcttggagctgagagaaaaaaattgac
accactagtaagggacaagctgcatgcaaggcttgccatagtcagggcaggaggacaggg
gcctgcgggaagggccagggtggggacgagtgaagtaggagtggcctgggccactgttga
ccaagacaaatcagatgggaggcggtggggatctggtgtattaaatgccctgccttctga
tggtgagggaacactgcagttaggagcatggacactctggtgttggccaggcctggcttg
aatccagcctctgtcacttaacctcactgaaccttagcagaatgggttcatcgtacctgc
ctcttgaggtggctggcagtgatgaaatgacacataaagc
>IGR1060a
aggcggtggggatctggtgtattaaatgccctgccttctgatggtgagggaacactgcag
ttaggagcatggacactctggtgttggccaggcctggcttgaatccagcctctgtcactt
aacctcactgaaccttagcagaatgggttcatcgtacctgcctcttgaggtggctggcag
tgatgaaatgacacataaagcacgtgcaccaggcctggtgtaagcagtgctcagacatgt
gagctgttactagtggggcaaggagcggactctactaaggaatcctcctgtaagggcggg
cctatgatggtgctggggagaatggctgcattgttatggtcaaaatccagttggcaaatg
ccacatggttctgggagggtgctggcccttctctgctgtcctctgttcaggaatggctga
gtaggagctggcagtggcagacaaggccaggccaggagagcaggtagtccctggggagtc
tgccagacacctccataggtccatccacagtgctgagccccccagcccagctcctctctc
cctcatggctgggccgggccttggtccatggagatttttcctgacctacaggcatcttag
gaccaggcccagcctgctcatgacctcatcttgggaatcacccaccctggagccctcata
gctaggaccctggctagccgacactcaccttctggttctg
>IGR1061a
tccatccacagtgctgagccccccagcccagctcctctctccctcatggctgggccgggc
cttggtccatggagatttttcctgacctacaggcatcttaggaccaggcccagcctgctc
atgacctcatcttgggaatcacccaccctggagccctcatagctaggaccctggctagcc
gacactcaccttctggttctgggtgatgttgaccagctcctcaatgagctccctgagggc
tgtagagggaggcacagggcctggggaggcaaagccgccaaggcaagtgagagcaatgac
cgtggtcaacaaaagcgccatgaggcccagtgccaacaggagaggattgaggagcggatg
cnnangctgggtggcttgtggccttggcgtcttgtggcagcttttataggcccaagtggt
gacgcctgacaccatggtctctgctttttcaggcactatctagaaaccacatctttactc
atcttgattttactttgtggaaaatccagtgtcgcataaaggaaagagtttgatttctca
tggacttattgagaagggtccagggcagagtttccaagatctgggtgggtttaattccag
cggcaggcaaggggccctgagagcggcgtggcatttgcaatgctgccctgagttccagca
gttttgcctgtgacaaccctgagtacctggacagctgacc
>IGR1062a
gaaaatccagtgtcgcataaaggaaagagtttgatttctcatggacttattgagaagggt
ccagggcagagtttccaagatctgggtgggtttaattccagcggcaggcaaggggccctg
agagcggcgtggcatttgcaatgctgccctgagttccagcagttttgcctgtgacaaccc
tgagtacctggacagctgacccaactctgagctcctgtcctcagacccttttgggtcacc
agaagtgctgagcagatagtcttagtgcactgtggctgtgaccacagtctaccagctatg
ggaatttggggagttttattttttcgatgaaccagtctcttaaattacttaagtaacact
tgcttggatacaaaattcaaacaggcaatagaagagtaaagttcacttcttttggcttgc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-195
ctaattcctccttggccccactgtgagagggattgtcaaagttcagatttccaggtctcc
actgagagatccagaaagattcagaggtctttctgggagcttttttggtgtttttttgtt
ttgttttgttttgtttttttggagatggggtctcactatgttgcctgcctaggctggcct
ccaactcccagactcaagcgatccccccacctcagcttccagagtggctggaagtagtgt
gcacgtgtctggcccctttaatttaaagtgtatgggccat
>IGR1063a
ttcagaggtctttctgggagcttttttggtgtttttttgttttgttttgttttgtttttt
tggagatggggtctcactatgttgcctgcctaggctggcctccaactcccagactcaagc
gatccccccacctcagcttccagagtggctggaagtagtgtgcacgtgtctggccccttt
aatttaaagtgtatgggccatccttctgggaaactcttaactgggccaggctggcagcct .
tagtccaggtcagagantgtnnrmrintnctagtgncactggggcttggggtgatcccttt
gctcaccagtctctgcaggatcaacccctgccgtctgggggcctcaaatttcccttctgc
agaatgagtgctgtggagggcggctcctgggcttggcccctgcagccatgtcgccttttc
ctgctcttccctcnttttcctagaagtcctccagaaacccccacagcagaggccacggca
tttgcctgttgggtgttgatgtcaagatttctcccctacccacttcctccccgaaccagc
gcctccccaggccccctctctgcctgctcaggctccctccgtcctgtcctcgatggggct
caacctcctcacaagggtgtgcttgtgaccctcctcacaaggcatgctggattcccgctc
agaggcatcccaggcttgcccaccctctcttcccacaggg
>IGR 1064a
tgtcaagatttctcccctacccacttcctccccgaaccagcgcctccccaggccccctct
ctgcctgctcaggctccctccgtcctgtcctcgatggggctcaacctcctcacaagggtg
tgcttgtgaccctcctcacaaggcatgctggattcccgctcagaggcatcccaggcttgc
ccaccctctcttcccacagggaacgtcattcccaccctctctgtccacactcgaagcttc
ccagcccagctgctggctctgactcccagaagtctgccccttcccctcgagggcccccag
tgcctggagtgccgctacttggccgtgtgaccccnctacgggcctgtttcctaatctgta
gtagagggcccacggcatctcccacagggtctccgtgatgggggaaggagcggggaacta
ccttggtctgtgcaactcccggagccccgcccgggtgagtcaacgccccttatcccccat
ggccaccaaaagccctgccgggagcggtgggcaggggcgcccccgcgcgtgggagaaggc
gctggcgcggcggttgcggcggcgatggcccgcggagataggggggtggccttatgtaac
gggagatgggcccgataagcgggatctgcgcggccgggccctcctccgcggcctccggcg
gtggccggtccgggaggcaggggtgggcgcgcagaccggc
>IGR 1065 a
gggagcggtgggcaggggcgcccccgcgcgtgggagaaggcgctggcgcggcggttgcgg
cggcgatggcccgcggagataggggggtggccttatgtaacgggagatgggcccgataag
cgggatctgcgcggccgggccctcctccgcggcctccggcggtggccggtccgggaggca
ggggtgggcgcgcagaccggccagtctggaagctgcggaggctggcgagggggcggcaaa
ggtggcggtccgagcgccaggcagggcaagggccggctggacacccgggccagcggctcc
ccgagcgccggtgcgcaccggcgaggggcgggagcggccgaggggccgaggcgcgcacgt
gccgctccagcaccggccatgtcaggccgagggaccccgcgggcccggccgagcggcagc
ccctgccctggagggtggtctccagggaccaaggcgtggcgggcggtgcggagaggcgcg
gcacagatggctacatcagagggtctgttgcttgtttctagattgtcagcggggatccac
tcccgtgcgggtaattttaattaacactaactaccaaagggccgctccgggcacttggcg
catgtggctcgcacctgcctgcaatgcgctgcgtgggccgcccgcttatggccatgggga
gcctcttcgctttgctctggccccgaagcgctgggattgg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-196-
>IGR1066a
agggtctgttgcttgtttctagattgtcagcggggatccactcccgtgcgggtaatttta
attaacactaactaccaaagggccgctccgggcacttggcgcatgtggctcgcacctgcc
tgcaatgcgctgcgtgggccgcccgcttatggccatggggagcctcttcgctttgctctg
gccccgaagcgctgggattgggacctcccttcctcccgaccagctcatcctgggaaagct
ggggttgctttttcgggtttctctggactctgggtctccgttggcaaagacatgatgccc
agtcaggaggagtaaggcctgagagagttgtttttgtaagtgaaaggatttaatttttta
gatttttatttttaggaaagttacgaatgcagataattttaaaaatcaagaaggctgatt
atgtaaaacggcagcgctgggaatccgtgctctatgggcctctggcattgctgctcctct
tgtgagtgaggcacttactgccctgctgtgtcccttactgtcttttaaaggttgtttata
ggccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgagatgggcgga
tcacgaggtcaggagattgagaccatcctggctaacacggtgaaaccccgtctctactaa
aaatacaaaaaaattagccgggcgtggtggtgggcgcctg
>IGR1067a
gccctgctgtgtcccttactgtcttttaaaggttgtttataggccgggcgcggtggctca
cgcctgtaatcccagcactttgggaggccgagatgggcggatcacgaggtcaggagattg
agaccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaaaattagcc
gggcgtggtggtgggcgcctgtagtcccagctacccaggaggctgaggcaggagaatggc
gtgaacccgggaggcggagcttgcagtgagccgaaatcgcgccactgcacttaagcctgg
gcgacagtgtgagactccgtcttaaaaaaaaaaaaaaaaaaaaaaaaaggttgttaagaa
aatcacaaggaaggaggaaaaaatatatttcctattcattaagtggaggtggaacatcac
aaaggtcttcagcgtcactgtcttcacgttgagcaggccgaggaggaagaagaggagggg
tcggtcttgtcatctcaggggtggcagaggcaggagagaatccgtggataagtggatctg
tgcagttcagaacctgctgttcaagggtcaactgtgtatgtaaaaaattcagtggaatct
ccaccttccctcacaagtaactatttttcttaggtgttgtttttttttttttttggtatc
ctattagtttatgtaaatacaagcaactgtgaatatatgg
>IGR1068a
ggtggcagaggcaggagagaatccgtggataagtggatctgtgcagttcagaacctgctg
ttcaagggtcaactgtgtatgtaaaaaattcagtggaatctccaccttccctcacaagta
actatttttcttaggtgttgtttttttttttttttggtatcctattagtttatgtaaata
caagcaactgtgaatatatggtcttattttcccttgtccctacatgtgaagtggcatcat
atacaccttttgcaccctgtttttctcacttactataaaaataatatatttttgtattca
cacttagattgggacattttatgacttttcttctttgttctctcttattggaactgccat
tttttttgactatatacctcttggacttgtcctttaattttctttttattctattttcca
tttaaaaaatttctcttctctgggatattctcatagctttatcttcctgagggtatttga
ttctttgtgtgtgtgtgcgcatgtgcacatgcacgctaacagcactatgttcttgtttca
ttgatatcttctaagtttcctttttcatacataatctttattttctgcaagttttcttta
aaaaattgttttgaactgggcgcggtggctcacccctgtaattccagcactttggggggc
cgatcgcttgagcccaggagtttgacaccagcctgggaaa
>IGR 1069a
catgtgcacatgcacgctaacagcactatgttcttgtttcattgatatcttctaagtttc
ctttttcatacataatctttattttctgcaagttttctttaaaaaattgttttgaactgg
gcgcggtggctcacccctgtaattccagcactttggggggccgatcgcttgagcccagga
gtttgacaccagcctgggaaacatagggagactttacttctacaaaacataaaaaaaact
tagccaggcatggttgtgcatacctgtgatcccagctacttgggaggctgtgtgggagca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-197-
tcacttgagctcaggagtcgaagctgcagtgagttgtgatcacaccacttcactccagcc
tgggtgacagagccagaccctgcctcaaaaaaaattttttttccatcttataggctttcc
ttgcacgttaggtaatcctggattgcctgcacatgttaaaacagggatctctgagggtaa
ttgtgtgggagggggctgtttcctatagggcaggtggctgactgttttcacttggggaac
ctcctgtggcagtttctttgtcgtttttttggcaggcaggtcagctcgcgcagaaaagat
tctccctgtctccagcattccagcagcaagggtggagagagggctggggtgggggcctca
gcatctgttgactgttcctgatttcagcatatttcgaccg
>IGR1070a
ttcctatagggcaggtggctgactgttttcacttggggaacctcctgtggcagtttcttt
gtcgtttttttggcaggcaggtcagctcgcgcagaaaagattctccctgtctccagcatt
ccagcagcaagggtggagagagggctggggtgggggcctcagcatctgttgactgttcct
gatttcagcatatttcgaccgccctctactgtgtctagtgtttcttggtccagatatcct
atccggagaaaaccctgctgcaggagagtcactcgactttgatgaacaaaaatggatatc
taactgtttcttaaactgagtttcaacaactttccttattttcacccccttctcttctga
tgtccttggtcttctcccagttcctgagcattcttgggattctgtaaatcaacataggtc
tcagctggcctaggattcagttttcttgggtcagccaagtagtctgcccaccgtccctcc
actttccacctttcaaacgctggtgctgtcatccatttctcccattttggtgggtttaaa
actttagaaaattcagttactgtcattttagttggttataaagtgggagtttgtgtttat
tccattgttttcatttggaatttatatttttaatgtagagaatttataaacaagacaaga
aataagaggcaaacactagtcttgcaccccttttccctgg
>IGR1071 a
ctggtgctgtcatccatttctcccattttggtgggtttaaaactttagaaaattcagtta
ctgtcattttagttggttataaagtgggagtttgtgtttattccattgttttcatttgga
atttatatttttaatgtagagaatttataaacaagacaagaaataagaggcaaacactag
tcttgcaccccttttccctggcactataacacctctgtatctttgctatgcacatttaca
ttttgttagaaaaatgagataatacattatatagtttttactcctttttcacttaaaata
tatgaagagcattctccaatgtcagtattctgcatttaaaaaaagattacacaaaatgtt
attgtgtaaagtacagatatgcaaaaaaataaaaagccccatagtcccagcatccagaga
taataatcattgtaatattttggtatctgtcatgctagtatgtggatatgtacagggtaa
gtaccttattcctaaaataaaagggaaataactttttttctttttctttttttttttttt
gagacagagccttgctctgtcacctacgttggagtgcagtggcaccatcttggctcactg
caacctctgcctctcaggcacaagcaatcctcccacctcagcctcctgagtagctgagac
tacaggtgagccaccacacctggctaatttttgtattttt
>IGR1072a
aaagggaaataactttttttctttttcttttttttttttttgagacagagccttgctctg
tcacctacgttggagtgcagtggcaccatcttggctcactgcaacctctgcctctcaggc
acaagcaatcctcccacctcagcctcctgagtagctgagactacaggtgagccaccacac
ctggctaatttttgtattttttgtagagaccaggtttcaccatgttgcccaggctggtct
catactcttgggctcaagcaatttgcctgccttggactcctgaagtgctaggattacagg
tgtgagccactgtgcctggctgacatattttatttacttattagtattttttttgagatg
gggtctcactctgacacccaggctgaggagcaatggtgcaaacacggctcactgcagtct
caaacccctgggttcaagtgatcctcccacctcagcttcctgcgtagctgggactacagg
gcaccatcatgcccacacacattggctgatttttaatttttttttgtagagatagggtta
aacctttagacttaccacggttttactaataccagatcaaagaggtgcaagataaatgtt
tgccttttattgcttgtctcttttataaattctctgcattaaaaatataaattccaagta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-198-
aaaacaatggaatgaacataaactcccacttcataaccac
>IGR1073a
cattggctgatttttaatttttttttgtagagatagggttaaacctttagacttaccacg
gttttactaataccagatcaaagaggtgcaagataaatgtttgccttttattgcttgtct
cttttataaattctctgcattaaaaatataaattccaagtaaaaacaatggaatgaacat
aaactcccacttcataaccactcaaaccatagtagcaacaaccttatcctgttgcccagg
ttggtcttgaactcctgtgctcaagtgatcctcttatcttggcctcccagtgtgctggaa
tcacaggcatcagccactgcacctggcctattacttaatctaatacatttctgcgccaag
ccccggaagacaaataattacaaataattcccataacaatgataagttcatacattcatt
aagtaaatgtttattgagtgcttactgtgtaggtgctaaacaaaacagcacagtctctgc
cctcttagagatacattctagtgggtagagataatgaacaaacacatgatatatagtatg
ttagaccgtgaaaagtacagtggagagggaaaaaaaagagggcaggtagaatgagtgagt
acactattatatatgggatggtgacgtaaggcatcactgagaaggtgttatttgagcaga
gacctgaaggatgagaggaagtggccatgcagatatttgg
>IGR1074a
agtgggtagagataatgaacaaacacatgatatatagtatgttagaccgtgaaaagtaca
gtggagagggaaaaaaaagagggcaggtagaatgagtgagtacactattatatatgggat
ggtgacgtaaggcatcactgagaaggtgttatttgagcagagacctgaaggatgagagga
agtggccatgcagatatttgggggaagaaatttccaagctgaaggcacaagtaagtgcaa
aggcccttttcttattttgttcatgctgctgtaacagaacacctaagactgagtaattta
taaataataaaaatttattgcttacagttctggaggttgggaaatccaagatcaaggctc
cagcagaattcgtgtctggtgagggctgctctctgctcccaagatggtgccttcttgctg
tgtcctcatgtggtagaagagccaaagggaagaactttctccctcaagcccttttatgag
gtcatgaatcccattcctccatggcctaatcaccttttaagtgccccacttcttaatagc
atcaccttggggattaagttccaatgtatgaattttggagggaa acatacactcaaacca
tagtagcaccaaagcaggaaaatgcccactgtgctgagaattagcaaggaaagccagaag
gagtgaggggaggcatgggagaagatactgtcagagaagt
>IGR1075a
catggcctaatcaccttttaagtgccccacttcttaatagcatcaccttggggattaagt
tccaatgtatgaattttggagggaaacatacactcaaaccatagtagcaccaaagcagga
aaatgcccactgtgctgagaattagcaaggaaagccagaaggagtgaggggaggcatggg
agaagatactgtcagagaagtatgtccagagcatatggagacttgtaagccattgagagg
actgaggatttcatgatgagtgacatagggagccactggaggttttgagcagaggagtga
catgactcaatttaccttttttctttttttaaaaaaatttgaattaacgttatatttacg
gaaaagatacaaaaatagtacagacagtttccatatcccctccacttacccagcttctcc
caatggtaacacattacataatcatagtgcaatgatcaaaaacagaaaaatgagcatgga
tttattaagtaaactggatcctattctaatctcaccagtgtttccattcacatccttttt
cagtttcaagatcaacccaggatctcacagtgcattgagttaattctctttggtctcctg
cagtctgaatggttcctcagtcttgtctttcataacgcttacattttccaggaatactga
tgagttatgctgtcaaatgttcctcagtttggtccccttg
>IGR 1076a
cctattctaatctcaccagtgtttccattcacatcctttttcagtttcaagatcaaccca
ggatctcacagtgcattgagttaattctctttggtctcctgcagtctgaatggttcctca
gtcttgtctttcataacgcttacattttccaggaatactgatgagttatgctgtcaaatg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-199
ttcctcagtttggtccccttggtgttttctcctaattgcactgaggttctacattttcac
agagatgaagttggggccttctcactgcatcaggtcacagggttcatgaggtacatgcct
tcttattggtgatgttgaccctgaccacttggttaagatggtttctgtcaggttcttcca
tgataaaattactatctttccctttttagttaatatattgggaaagatagtttgagatta
tataaattttttctcagatttgtgcctactaatattagcttcatcagtgactcttgtctg
aaatgatttttattgtggtatttgcctagtgatgacttttctttttccctttccttctac
atttattacttgtaattctactataaagaagtgctgtccttgtccctcattttttttaaa
gtaagtacttgtgtatagccacataagttcatgaatatttattttactctatcggttata
atccaatactgtctttattttgtttctcaaattgttctac
>IGR1077a
atttgcctagtgatgacttttctttttccctttccttctacatttattacttgtaattct
actataaagaagtgctgtccttgtccctcattttttttaaagtaagtacttgtgtatagc
cacataagttcatgaatatttattttactctatcggttataatccaatactgtctttatt
ttgtttctcaaattgttctacctttgatcattgggagttacttcaggttgggttctgtgt
tctttgaacaaactctacctttttttttaaaaaaaatattttcttaatttctggcaccac
aaaaaattctagggtcattttgtattttccttgcctcagccctgaagtcaaccacttcac
caaggagccagagttctttttattgaagagcgtgttttaaaatcgagatcttggaagtag
gtgtcctcattattactggggtgtcatcacactgggccctctttaaataactttgttact
ttcactataagttttcattattttcttagtggttaccctggggattacaaatgaacacct
taatttagatgaatgtcaacttaatttccatttcaaaagttcctatatagctctgttgcc
tctctcttttgtagcattattgtcatataaattatatttttatacattataagcccatca
acagtgttaaaattcttaatgcagttccctttcaatcatg
>IGR 1078 a
attttcttagtggttaccctggggattacaaatgaacaccttaatttagatgaatgtcaa
cttaatttccatttcaaaagttcctatatagctctgttgcctctctcttttgtagcatta
ttgtcatataaattatatttttatacattataagcccatcaacagtgttaaaattcttaa
tgcagttccctttcaatcatgtaggaaaagagttacaacccaaaatactttttttttttt
tttgagaccgagttttgctcttgtcaccaaggctggagtgcagtggcgtgatctcagctc
accgcaacctccgcctcctgggttcaagagattctcctgcctcagcctcctgagtagctg
ggattacaggcgcccaccacaacgcctggctgattttttgtatttttagtagagacaggg
tttcaccatgttgggcaggctggtctcaaactcctgacctcaggtgatccgcccacctcg
gcctctcaaagtgttgggattacaggcatgagccactgctcccagcccccaaaatacatt
tatacttttatattacctatatatttacctttaccagtactctttatttgagtattcatg
agcatttgagtctagtttcattttaccctaaaggattcattctccttttatatttcttgt
agggcaagtctggtgaagacagattatcacaatgtttgtt
>IGR 1079a
ttacaggcatgagccactgctcccagcccccaaaatacatttatacttttatattaccta
tatatttacctttaccagtactctttatttgagtattcatgagcatttgagtctagtttc
attttaccctaaaggattcattctccttttatatttcttgtagggcaagtctggtgaaga
cagattatcacaatgtttgtttatatgggagtgtcttcatttcttgtttttgaaggacag
tttttctggatacagaattcttgattgaggctgggcacagtagcccacaccttaatccca
gcactttgggaggccaaggtgggaggactgcttaagactaggagtttaagaccagcctgg
gcaagacagcaagaccccctgtctcttaaaaaatttttttttttgagtgtggtggcacat
gctggtagtcctatttgagaggctgaggaaagagaattgcttgagcccaggagtttgaag
ctacagtgagctatgattgcaccactgcaaaaataattcttggttgatagtctttttcat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-200-
tcagcactttgaatatgtcatctcactgctttcaggcctgcattgtttcttaagagaagt
cacttcttagctttacttgcttctttcgtttgagatctctttttcaacaatttgaccatg
atgcatctaaatgtgaatccctttgagtttaccctacttg
>IGR1080a
caccactgcaaaaataattcttggttgatagtctttttcattcagcactttgaatatgtc
atctcactgctttcaggcctgcattgtttcttaagagaagtcacttcttagctttacttg
cttctttcgtttgagatctctttttcaacaatttgaccatgatgcatctaaatgtgaatc
cctttgagtttaccctacttggagtttgttcaatttcttggatacgaagattaatgtttt
cataaaatttgggaagttttgggctactatttcttcaaatagtctttctgctcctttctc
tctctctctcttctgggattctcattatgattggtatacttggcattttggtacacttga
tagtgtctcaaaggtctctgaagctctcttcatttttcttcattcttctgtctattcctc
agactgtataatctcaattgaccggtctttgaactcactgattctttcttctgccagttc
aaatttgctgttgacccccatctagtgaatttttatttccattactgtatttctcaactc
cagaatatctatttgattcttttttataatgtttgtctccttactgatagtcctgataat
ttggtgaaacatcattctcataatttcctttaattctttagactttgtttctgttagttc
cttgaacatgtttataatagctgatatctaaagtctttgc
>IGR1081a
atctagtgaatttttatttccattactgtatttctcaactccagaatatctatttgattc
ttttttataatgtttgtctccttactgatagtcctgataatttggtgaaacatcattctc
ataatttcctttaattctttagactttgtttctgttagttccttgaacatgtttataata
gctgatatctaaagtctttgcctagtaagtctaacatctgggcttcctcatagattgttt
ctattgactgttttttaaattgctgtttatggcatgggtcagatgttcctgttctttgtg
tgtcttgttttaaatactctatcaattattgaagtcagattacctactctccagggcttg
cacctgttactatttcttattgttgctgctgttggtttgttctgtgtctttcctggacta
attctgcaaattctatatgctttgtcatgtttggttcctgaagtctctactcagcctagt
gggtaagcgaataattggacagatatttctttctaatgccttgaaccaataaattttcta
gcttttgtcaagtgtgtgcatgtgtgtgtatttgtggagtcatgtcattgatgtgtcagc
agacagtttacaactgcctttatcttcatttctggcatgaattgagtttcaaggtcagtc
agagatgagagcttaggaccctctcaggacatgcatacat
>IGR1082a
cagatatttctttctaatgccttgaaccaataaattttctagcttttgtcaagtgtgtgc
atgtgtgtgtatttgtggagtcatgtcattgatgtgtcagcagacagtttacaactgcct
ttatcttcatttctggcatgaattgagtttcaaggtcagtcagagatgagagcttaggac
cctctcaggacatgcatacatccctgcacatgcacatggacttctagattcccaggaata
tgcttgagcttgtcaaagctcccgtggacatcttcttcccagatttttccttttaagttt
cttggtcagccttttgttagctccacctggtaacgctgcctcaggcagccacagggttaa
tcagttgccactgattattctgcaggaagggctgttttcagagtgagctctgagttaagt
caaataaagataggtcctgaaaatggagcttttcagtgagttgccagacaagacaaatag
aggcagttctctagtagtggagatctgggggacctccaaatctattctgtctcctccagt
ggctactaggttgctgattttcacagatactaagagggctgttggttttcaagttaccat
ggattaagagagaagggcatgggattagggcaacttaaaatgccactttctgctctgaga
ttcagctgttttcctttaataaacacacctcagtttgtcg
>IGR1083a
gagatctgggggacctccaaatctattctgtctcctccagtggctactaggttgctgatt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-201
ttcacagatactaagagggctgttggttttcaagttaccatggattaagagagaagggca
tgggattagggcaacttaaaatgccactttctgctctgagattcagctgttttcctttaa
taaacacacctcagtttgtcgctatccattagttaatttccaaagttctgaaaaagttga
ttttgacatttttgccagtcttattgcttttatgaagaagcagattttggatggctttta
ctccacccttatggaagtagaaatcctttagatattaaaattataaatttgtacagatcc
tttggattcaatcaacaccaaggggttctttttatggcctcctttcctgatatgcaaaca
cctttttccaacagtgagaaactcagttcgtattatctacaacacaggtatgtatttgtt
tgactttagtatgtacataaaaatttcgaaattgctaacccacacccctgtgagaaacac
attttcttgagttactttttaaaaagatcactggctgctgtgttgagaactacagggagc
aggccccaaatcagtgggagcagttacgtggttactcagattattcaggttagagatggc
agtggcttggaccagagcaatgatggtttagatcaggggt
>IGR1084a
aaaatttcgaaattgctaacccacacccctgtgagaaacacattttcttgagttactttt
taaaaagatcactggctgctgtgttgagaactacagggagcaggccccaaatcagtggga
gcagttacgtggttactcagattattcaggttagagatggcagtggcttggaccagagca
atgatggtttagatcaggggtccccaacccccgggctgcagaccattacctgtcctcagc
ctgttaggaacagagtcgcacaacaggaggtgagtgacaggtgagggagcattaccgcct
gagctctacctcctatcagattggtggtggcattagattctcacgggagtgcaaactcta
ttgtgaatttgcacgtgagggatctaggttgcgtgctccttatgagaatctgactaatgc
ctgatgatctgagatggaacagtttcatcccgaaaccatccccctcaccccacccgtcca
tggaaaaattgtcttccactaaatcggtctctggtgccaaaatggttggggactgctggt
ttaaatggtgaggcatggtcagattccggatgttttgaaaattgaacccatagtattaaa
ctgacgaattagatataagatgtaagataaagaatcaaggataatgccaatttttgcctg
agcaattggaataatggagttgccattaacagaagagatt
>IGR1085a
taaatcggtctctggtgccaaaatggttggggactgctggtttaaatggtgaggcatggt
cagattccggatgttttgaaaattgaacccatagtattaaactgacgaattagatataag
atgtaagataaagaatcaaggataatgccaatttttgcctgagcaattggaataatggag
ttgccattaacagaagagattcaagttctgggagaaagactggttttggtcattttaagt
tttagacgtttattagatattcaagtgcagatagatgcccagttatccacaggcagctga
atatatcagtcaagcatttaggagagatctggattggacacaaacatttatgagttatca
gtgtatagatggtggttgtaggagtggtcagtgccctgcctatatcctatgatcctagga
actgccagtgtgctcctgccaactttcagctgctgctgcttttttttttttttttttttt
gtctttttagacagggtctcactctgccacccacccaggctggggtgcagtggcacaaat
cacagctcactgcagccttgaaccctcagactccagggatcctatctcagccaagtagct
gagactacaggtgtgcaccaccatgccttgctaattttttaaaaattttatgtaaagatg
ggatgtcactatgttgctcagactttctttttaaactgtg
>IGR1086a
cactctgccacccacccaggctggggtgcagtggcacaaatcacagctcactgcagcctt
gaaccctcagactccagggatcctatctcagccaagtagctgagactacaggtgtgcacc
accatgccttgctaattttttaaaaattttatgtaaagatgggatgtcactatgttgctc
agactttctttttaaactgtggaaagcagctgtgtcggtacacatggcaagccagtaact
aacatgtgctagaatagccttcactcagtaaccctggcaagttgttatataaatactcca
ggtctcttgccccttaggtgggataattctgaggtatatattttgccaaactccccagag
tctccctggggcaccaaactctaattgcccacttaccgtagctggcttaatagtaaactt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-202
ttcattggctgctttctctttcatacacaatttccccaatttcctactgattactttcac
gtgaagcattgttttacgctctgcttctgggagaacccaaactaagataatttaaagcta
tgagactggatgagatcaccaaataagtgagcacagagaagaaaagaggtgcagactctg
agtactaaaacctgtgacattgaggggccagggaaatgaggaggaaacagcaaaggaaac
gggatgtgcaggtgttgcagggaggaggcagagctggatt
>IGR1087a
tctgcttctgggagaacccaaactaagataatttaaagctatgagactggatgagatcac
caaataagtgagcacagagaagaaaagaggtgcagactctgagtactaaaacctgtgaca
ttgaggggccagggaaatgaggaggaaacagcaaaggaaacgggatgtgcaggtgttgca
gggaggaggcagagctggattccagtagggctggggattgtcgggacagtttgagtacaa
tgcagtggagggtgacataatgatgagccatggaatttaagttgaataaggagagaagta
caggcatcagggaaacaacctgtgaaaaagccatagaatcaatggattgaaatctcagtg
gggtcaaagaattgctggggttgaggaccacaggaaaattgtagacaccatggggttatt
ggagagtgagatgcttaaaactgagattttggaggggtgcagttattgttattaaaagga
cggggctctagaataagaccatagaactgagtatcttctcactggaggaaacaaaaaggg
gctgagggaggccaaggtaggcagatcacttgaggccagacgttcaagaccagcctggcc
aacaaggcgaaaccctgtctctactaaaatacaaaaattagcctggtgtggtggtacatg
cctgtaatcctagctacttgggaggctgaggcaggaggat
>IGR1088a
catagaactgagtatcttctcactggaggaaacaaaaaggggctgagggaggccaaggta
ggcagatcacttgaggccagacgttcaagaccagcctggccaacaaggcgaaaccctgtc
tctactaaaatacaaaaattagcctggtgtggtggtacatgcctgtaatcctagctactt
gggaggctgaggcaggaggattgcttgtatcagggaggcagaggttgcagtgagctgaga
tggtgccattgcactccagcctgggtgacagagcaagactccacctcaaaaaataaaaaa
gactgagaggccaaggagttgtattagaccatcacttggatattgaaatcagcaatgatt
attagtaatggggtgacactgaaccgggagctaaactcttcaacaaataagagggagtga
ccaagctgggaatgaaagataactgcaacaagagtgaaatgaagacagctttttcttgaa
cacttacacagtatttagtaggtggcaagcagttctaagcagtttgtaaataatgtcatt
caatcttcataacaaccctacaaaatatgtaccattttacccacttttacatataaggaa
acagaaaacaggacaaataacttgctcaaggtccccagctagtgagtggtgtgctaggat
ttgagcccaggcagtctggctcattctaacctccatccat
>IGR1089a
aggtggcaagcagttctaagcagtttgtaaataatgtcattcaatcttcataacaaccct
acaaaatatgtaccattttacccacttttacatataaggaaacagaaaacaggacaaata
acttgctcaaggtccccagctagtgagtggtgtgctaggatttgagcccaggcagtctgg
ctcattctaacctccatccatgctgtgatggctattcattccaatgtggggaagggggat
atttggagactgatctagaagcagcaatgagaagccagaaaggcacctatcccacctcca
aacccatgggcttcttggaatgaaagcagccactctcagaagtgctgccaaggatgccac
atattcagggggaaaccagatttaaaattgggaagtctgttttaacttgcaaatgatact
tttgtttcactgcctatattgatcgtgtattgcctttgttattctttgctgcaacaacta
gcactttcattaacatgttgatagaaggtaactggctttaatatttactgagaaatgttt
tattttgcagttaagatgactgtttaattttgatttagcaacagataacattaagaaaat
attatttgcaaaactgtgagtttgctaaagctaggagatgttgaattttatcaaatatag
ctgctaganttttttcagaatttttttcaccttcggtttt
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-203
>IGR1090a
gatagaaggtaactggctttaatatttactgagaaatgttttattttgcagttaagatga
ctgtttaattttgatttagcaacagataacattaagaaaatattatttgcaaaactgtga
gtttgctaaagctaggagatgttgaattttatcaaatatagctgctaganttttttcaga
atttttttcaccttcggttttattatagtgatggatttatcaacagatttttcattttct
gaaatcttgcattcttgggataaaaatatcttggttattgtggatgtttaatatatgact
agaattgatttgctcttaatcttactcgtgattacatttaggacccccccccaccccacc
accacccccaggatactctgtcttaaggtccttagctttaatcacatctgcaaagtttcc
tttgctgtataaagtaacagtcacgggttctagaaatcaggacctgtctatctttggggg
ccaaccatttaacctagcacagatagatgccttaggaccttagggcttaattctcttctg
gacccagttgagaaaagctgtctaggcaaacatgctcattatagctacagatggcacaaa
accatgccatgtgactgaatcaagacccggtatggtcctggctgactctgaatgacaaaa
ctctacaaagcataattcaaaagcgtgtgacttggttgca
>IGR1091a
cagatagatgccttaggaccttagggcttaattctcttctggacccagttgagaaaagct
gtctaggcaaacatgctcattatagctacagatggcacaaaaccatgccatgtgactgaa
tcaagacccggtatggtcctggctgactctgaatgacaaaactctacaaagcataattca
aaagcgtgtgacttggttgcattctgtgtggaatggaaggattcaagatgtcagctggca
attccaggaaaaactgtgattaggcttttcttagaagtggcatctgaagagcaaatggag
aggcctgttcttccaggtctggttggaccctacagggagcaggccttgactctgtgagtg
agcctggcttgccttccacatggcaatgcccacttagagaggaatcaggattgatggtga
agccagtatgctacacaggatagacgcagaggagtgttacaggcttcttcacgatgggca
gatcaggcctcaagtggtcagagctttccaaaggtgggtgtgcacagtggagaatttcct
ctctgtagagagagctctgagtctggatgaccatctggaagggatatgtaggagaagaag
gtggtgggtactgacttagatgattacttaaggttcctgtcaaactttgagaccccattc
aactacttcaaattttagttggggaaaccaagtcccagag
>IGR1092a
agagctttccaaaggtgggtgtgcacagtggagaatttcctctctgtagagagagctctg
agtctggatgaccatctggaagggatatgtaggagaagaaggtggtgggtactgacttag
atgattacttaaggttcctgtcaaactttgagaccccattcaactacttcaaattttagt
tggggaaaccaagtcccagagagagaggtcactggatttataaagttaaaagcagagcca
aacatacatctcaccatttctggtcatcctcagatattaatactcagtttttcaaaccac
atgcaaggaagtaaattcagaggtaacatttaactatgatttaaaaaaataccaaaacca
taaattttcaaggcagtaattatctccttctcaacagtgctttgagaagaagcatgcatt
tgcactggggagggaggcacagagtcgagtctcggctgtactgctgaaccctgaaggcct
gacagaggctgcctggaatgggatgaagagcagcaaatcagaaacaggcaatctgtccaa
ttttcagtgaaacaagtttcatgattttagaacctctcaacatccaaaatcctagacaca
atgttcctttgaaagaatatattttcttattgactaagttgatatgagaaataagtttct
tattatacactttctgaggacctacatttctatggcattt
>IGR1093a
gggatgaagagcagcaaatcagaaacaggcaatctgtccaattttcagtgaaacaagttt
catgattttagaacctctcaacatccaaaatcctagacacaatgttcctttgaaagaata
tattttcttattgactaagttgatatgagaaataagtttcttattatacactttctgagg
acctacatttctatggcatttaaatcttggatatttttaatgaacattgaatcccaggga
gctaacactgcatttcacaatctctgagcactgatcgatgttctttttaatcctgtagaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-204
tttctccacatattcagaacgtcctaaaagctccacaaaatcttcatcatgagtgattac
cagaagctggaagttacgctgctgtgagcgactttttattatcctgcaacaatatattca
gaacatattattagtaaagagcataaccccttctttgatttgaaaagtcaccgcaaacct
tgtcagacacatgaacttgtgctgtgtgtcagggccccagctaccctgcaggaagtggag
gggtggccccaggccttcaggccagccaggcaggagtctcttctcctctccagacagtag
ggacacatggcctgactcctcacttaggtctggcttagggactcacaggaatacaagaac
tagtttcttccagatcagaagttctcactaaagcaggtat
>IGR1094a
tgctgtgtgtcagggccccagctaccctgcaggaagtggaggggtggccccaggccttca
ggccagccaggcaggagtctcttctcctctccagacagtagggacacatggcctgactcc
tcacttaggtctggcttagggactcacaggaatacaagaactagtttcttccagatcaga
agttctcactaaagcaggtataaatattttattgagttttccttaatatccaaactgttc
aactatagaaggcttactccttcgcctgggattttcctgacctgttactacttttctctg
gaagaaaaatttaaaagtaataaagacaaactacaggtaaggggaataacactgctttct
taagagctgggtctacttagaattctgccaccaccagtcactagatgcatcattactatg
acacacagggacctgagtgggtgttctgggaacattttgctgaggtaaccagcaatgtga
ctgaaacctgaaagactttttcttttagctagccacttatccccttcctggagctggatg
catttgaggtttcaaaagcactcgcccttacttgtgatgatggctgcagaaaggtggccc
tgcgctgctgagctctccttctggccctctctgccagaaagggactgtctggagccagga
gtgcctgaaacacctcctttgacctcagggaaactgcctt
>IGR1095a
ttcttttagctagccacttatccccttcctggagctggatgcatttgaggtttcaaaagc
actcgcccttacttgtgatgatggctgcagaaaggtggccctgcgctgctgagctctcct
tctggccctctctgccagaaagggactgtctggagccaggagtgcctgaaacacctcctt
tgacctcagggaaactgcctttttctctgccagcatagtccttatgcaagagctgcttga
caaccttggcgtctacactgaccccaggtgaatgtggtaaaaggtgtgcaattttaccct
cactggactttacctaatctcaaataagctttttgagtaagagctctgtcattcctcaca
gttctctgacacatgtggaaagctggggagacagtcctaaacccactaccactacctgca
gatgtcttagcagggcatgctaattgctgtgcatgacatgtgggttcctctggtaggttt
acaggaaaaccaggccaggaacccctcacagtgactctctccctgtgaacacacttgggg
agctgcaggatgtgtctggggctgctgttcaccatctagttcctttaggagggatctgaa
gaattactatcaaaaggtaaagcccagggcctggcaccaactggcttccccaagaagtgg
ggaacacagctagagaacgttttcatcacagaactctctt
>IGR1096a
aacccctcacagtgactctctccctgtgaacacacttggggagctgcaggatgtgtctgg
ggctgctgttcaccatctagttcctttaggagggatctgaagaattactatcaaaaggta
aagcccagggcctggcaccaactggcttccccaagaagtggggaacacagctagagaacg
ttttcatcacagaactctcttggttttgaagaactatcacaacctgtccccaaatgtgag
atacttactcaaccagagcatgtgcaagagatacttactcaaccagagcatgtgcaagag
attcaatgttttctcggtcaagatttgttgttggctcatccaaggcaatgatgccacagt
tgaggcagaacgtttcagccagggccaggcgaatgatgagtgaggctaatacctggaaaa
aagcccctatgtgagaagcccagcacagaccttctcatctcatggcaggcaagcagtcct
gacatgatcttttcagcagggaaaagtgggaaacgtcacaggttcactgttaggtaaagc
actgccctctgggagagcccagcactgggaccagattcttatgtcctccagaaggagaac
ctgcatgatctcagcctatcattcaccacaaaacaaaatgctcagaacaacgctgatgct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-205
ctcacataaaaaattacatcagctacaaccaacttgagac
>IGR1097a
ggaaaagtgggaaacgtcacaggttcactgttaggtaaagcactgccctctgggagagcc
cagcactgggaccagattcttatgtcctccagaaggagaacctgcatgatctcagcctat
cattcaccacaaaacaaaatgctcagaacaacgctgatgctctcacataaaaaattacat
cagctacaaccaacttgagaccaaaggctagaaacagagacaatgccatttatctgtaat
tttaataatcctgtaagatgagcaaccttaaaaattcttgacctggctatttgcctgata
atgggatctgttagaaaacttcgacacgttttctagagcctctcactttttctctgctac
ctttaaatttccatattcttgtgtataatcctgagactgagagaataaaaaagaaaatcc
taggtcaaagtatcaggagtatagaaatgtggtttcagttaagcttacctgtagaaaatc
caagtaactggaactgttaggcattttcgtggttactagaaacctaatactaaaaccctc
agacccactgaaaccatctgaggatacaagacacacagaattgagagagtagggctattc
taggaagtataaactactctggtgtgagctgtaagtcccctttccccctcagtttgtggg
tgggtgcgcacacatcagtgagttggtaattttagaatag
>IGR1098a
ggcattttcgtggttactagaaacctaatactaaaaccctcagacccactgaaaccatct
gaggatacaagacacacagaattgagagagtagggctattctaggaagtataaactactc
tggtgtgagctgtaagtcccctttccccctcagtttgtgggtgggtgcgcacacatcagt
gagttggtaattttagaatagtttatgtcttttctttaatgcctaggcaagccagaagac
agggccacagcttggccctgtgagggacaggcatttccttcctgtctttgaatccaaact
gctgtcaactctaccaccacccactcacatgcagagcccctggctggctgctagagcctc
agcaaaagccagtgttaggtaggctggaggcccacctccattatttgttctctcccctca
caccaaggagacaattattgctaattaattttcataactcagaatagctacaaaaaatct
ttttcctcaagatatttttgaaagtatttttaattcaaagagaccatgtttcaaactctg
tattttctcatttataattaccactaaaaatcatcaaagcacgtagggatactgattaca
gatcacaagtttgtcatttttgtagactatgatttagacagtaatctgcagatgctttaa
attgggatcagctgtctaggctgacaacataatacatata
>IGR 1099a
gaaagtatttttaattcaaagagaccatgtttcaaactctgtattttctcatttataatt
accactaaaaatcatcaaagcacgtagggatactgattacagatcacaagtttgtcattt
ttgtagactatgatttagacagtaatctgcagatgctttaaattgggatcagctgtctag
gctgacaacataatacatatatgcatggcatgttcttttttttttttttttttgagacgg
agtttcgctcttgttgcctgggctggagtgcaatggcacgatctcggctcactgcaacct
ccgcctcccaggttcaagcaattctcctgcctcagcctcccgagtagctgggattacagg
cacatgctaccatgcccagctaatttttgtatttttaatagagacggagtttcaccatgt
taggctggtctcgaactcctgacctcaggtgatctgcccgcctcggccttccaaagtgct
gcgattacaggtgtgagacaccatgcccagctgcatggcatgttctttaagcaaaaactg
caaactatgaaaatgagttagataatgtaagcatctatttctatgattttagaattttat
ttaaaaaaagtcaagggcctagaggtgttatcaagtgtaatcttctgccttgatctgaaa
gcagaaagctcaagtatctgtgacatctttgttacaaacc
>IGR1100a
accatgcccagctgcatggcatgttctttaagcaaaaactgcaaactatgaaaatgagtt
agataatgtaagcatctatttctatgattttagaattttatttaaaaaaagtcaagggcc
tagaggtgttatcaagtgtaatcttctgccttgatctgaaagcagaaagctcaagtatct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-206
gtgacatctttgttacaaacctgtgcacagtgaaggatccagccttgttccccaaggatg
ccatattcctgattctttaaaacttcattcctcttcctgatttccaatgtaggctgtcct
cacagagccttacctgaagccagatggcctgacccagcagctaagtctttgtgtatgctg
tggtagggacttagttctatgaggggctactttcttaatgagactccttactatactgga
atattcattctagcttaagctagaatctggtttgcaatactattatgtcattgattctga
aacatcttatggttataattgcattttttcattcctgctggcacataaaatagtggtatg
tcttataactgatgagacagtgaccttattctgataaggagtgccatgaaaactctaacg
ggtcttcagcttcttgttctacatttagcctatcctgtgagaatgcttcaggcccttctt
ttaaaagtctacataatgttgcaggaaatgttggttagct
>IGR1101a
tgcattttttcattcctgctggcacataaaatagtggtatgtcttataactgatgagaca
gtgaccttattctgataaggagtgccatgaaaactctaacgggtcttcagcttcttgttc
tacatttagcctatcctgtgagaatgcttcaggcccttcttttaaaagtctacataatgt
tgcaggaaatgttggttagcttcaggagagtgtaataatagtagctgagcctgattcatt
ttatatagcagcaaagagcttcccaccattcaggtgtagccttgggtgcttccactgcac
tgatgtttgtttctctctttcagttacttgggtgagttggctccccaggcttttgagata
cctgccttttgtccagcactgcatcgtcctcgcatatccaaggctgtgtctcccttcagc
atcaccactcggtagttataattccgccttttatcagaagctgatacattttcatcggca
tcagaccgtatttctatgtattcaatatctgacacaggaagaagaatattttagaggaac
ctatgctctgtagccttttgtcatttacaaacatatcaagtaagcctaggaacaacagat
gaggctgacattaccagaggaaaacaatggctggtgtggaaactctttctctggctggga
ggattcaagagcctggtggtctggccagaagcaacccaga
>IGR1102a
attcaatatctgacacaggaagaagaatattttagaggaacctatgctctgtagcctttt
gtcatttacaaacatatcaagtaagcctaggaacaacagatgaggctgacattaccagag
gaaaacaatggctggtgtggaaactctttctctggctgggaggattcaagagcctggtgg
tctggccagaagcaacccagatgccccagttcctcagcctcaactctttcttagtttccc
tgttaagagtttcctccaggccaggcgcggtggctcacgcctgtaaacccaacactggga
ggccaaggtgggcagatcacctgagggcaggagtttgagaccagcctggccaacatggtg
aaaccccatctctactaagaatacaaaaaattagccaggtgtgggagcgcgcacctgtaa
ttccagctactactcgggaggctgaggtgggagaatcacctgaacccaggaggtggaggt
tgcagtgagccaagattgcaccactgcgctccagcccgggtgacagagaagtgcgagact
ccatctggaaaaaaaaaaaagaaaaagaaaaaaaaaagagtttcctctggatggtttttc
ttattgcattttggcttatccctatctacactatgacagaacctattatgtcatcagcta
aatataatgcctactgcagtcaaatatgtaagtcctgtta
>IGR1103a
accactgcgctccagcccgggtgacagagaagtgcgagactccatctggaaaaaaaaaaa
agaaaaagaaaaaaaaaagagtttcctctggatggtttttcttattgcattttggcttat
ccctatctacactatgacagaacctattatgtcatcagctaaatataatgcctactgcag
tcaaatatgtaagtcctgttaggctctggaacagaaaactttacattttcttgctacaag
atgttgccaagataagaattcttagaaaatctcaaagacatgcttagaaaggggtccagg
gaggtaatgctggcatgatgagaggtcataaggggaagagctgcggagagggctttggaa
agagcatttgtgatacaccatggtactcaccttgtccacgataggtacttcgccacaggt
cacgtataattttattgatttcttccattttcatactgtgaaatttcattattgctctgg
aaaaggaagtcattggtacttcatatatataaaaaataattatgtgtaatagtaatatta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-207
aaatacataaaatatataatatataaaaaatagaaatataaataacttcctcaatatttt
caatggtaaaagtagaatatagtaagagctacaaaaataaacagcagcaaaactttgctg
cttggctaatactgaaaattggcaggcttatttctagtgc
>IGR1104a
ttcatatatataaaaaataattatgtgtaatagtaatattaaaatacataaaatatataa
tatataaaaaatagaaatataaataacttcctcaatattttcaatggtaaaagtagaata
tagtaagagctacaaaaataaacagcagcaaaactttgctgcttggctaatactgaaaat
tggcaggcttatttctagtgctccaggggtacccttctccatattcactctctaggatac
aacaaatactcctttacgtaaatacttaaatactgtgaaaacttcaggaaacataatttt
ttagacttttttcttaggccgtggtaacttattggagggaatgcttccactgatactcac
gggtcacaggaaggcctgctgaatggacgacagggagttaaagggtagaaggtttacggt
tagccaaggggcctgcagtctatggggaaaataggagaatcgaactgccaccttgtccct
cttctatcactgttaaggcttaccaaaagtcagcttcttatgttggttttattcctcaga
tcttagatttttaccaactggaagctttggttcagcgagaatgatttagaagcttaagct
gaactgacatcaaaattttattttacctttccttcacagattcagaaatcctaattctaa
atattaacttccatatttatattccaaatcctaactctaa
>IGR 1 l OS a
ttaccaaaagtcagcttcttatgttggttttattcctcagatcttagatttttaccaact
ggaagctttggttcagcgagaatgatttagaagcttaagctgaactgacatcaaaatttt
attttacctttccttcacagattcagaaatcctaattctaaatattaacttccatattta
tattccaaatcctaactctaagcactaaattccacttagtccagacatgtccctgtcctc
aactctcttttaaggtagtagtttctaaacactaaaaacaaagaggagaaatgtttgtaa
aagcaaaagtagcctgtcaaaacctaacattgttcccaccacagtcacctttcatcaaaa
agcccttaggttctttggaagcgggtttatgaactaataaatgttgcaccagtggtaaaa
aggcaaacattactgcgatcatcatacaaaggatgtgaggatgtgaggcgacttacttcc
atttgcaggcctcttatctgatgcatacaaaaaaagaaactgaatataatgctactgcct
ctgtagaatcatttcgtgatcttctggttcaccagcaagagagaaagaaatgactcaaca
taaatacattttaaatatcagatgaaggactgtgaagtagtagaagactggaaaaaacca
tattctgcttgttgatgagaatgcaacaagtctccatttt
>IGR1106a
gatgcatacaaaaaaagaaactgaatataatgctactgcctctgtagaatcatttcgtga
tcttctggttcaccagcaagagagaaagaaatgactcaacataaatacattttaaatatc
agatgaaggactgtgaagtagtagaagactggaaaaaaccatattctgcttgttgatgag
aatgcaacaagtctccattttctaccttatacatttatctcagcctaacattttatgctc
ctttcaaaaggagacaaaacatctaagtatttcctaaaaacaaaacaaaactgatggaat
gttagaccaatcatgtaaagactgcctttccatagcttatatatcatgatcctgattttt
caaatgacattaaaaaaaagttatctttccattcaagttaaaaatcttcaaaaactaaca
taagcattctaatgtggagaacaagctccagacaaggcaggggtggccaaggcgcacacg
tgcagtctgccttggctcccttatacaacacaggtggtgcatcctgtcccatggccaggt
ctgctgagacacagcactgcgggaaaaagatctagttcagggagaggtctcaacccacca
aagagtgtgtcggatggagttgatgactaccactgtgggacggaccattaactcatcttc
gtatcctctctgtctactatggaatttacagctgtactgt
>IGR1107a
cttatacaacacaggtggtgcatcctgtcccatggccaggtctgctgagacacagcactg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-208
cgggaaaaagatctagttcagggagaggtctcaacccaccaaagagtgtgtcggatggag
ttgatgactaccactgtgggacggaccattaactcatcttcgtatcctctctgtctacta
tggaatttacagctgtactgtgtaagagatggggatgactaaggtcgctacagtaatcta
cataagggaataacaatgataataatgattattattgatgaccatttaccatatgcgaga
caaaactatgctaaataatcaatttcatttaatccttacgacaatactgggaattagata
ctgttatctctatttaccattaacaaaactaagattcaatgaaatcagtgacttgttcaa
gatcagagaaaagtggctaggatattaacagcccttgaatatgacagttaaaattgaaaa
ggcagtcaaaattccatcttttaaagccaccagactcagttttatgagggaatgttatca
aatcttcaagacacacctagctcccaagtatataaggtatgacacagcaaggagaaacat
aaggggaaaaaagtacaaggctatttttcttatgaatataaacattctaaataaaacgaa
atttagtagtaagggtagtaaaaagaatatatcatgacca
>IGR1108a
tttaaagccaccagactcagttttatgagggaatgttatcaaatcttcaagacacaccta
gctcccaagtatataaggtatgacacagcaaggagaaacataaggggaaaaaagtacaag
gctatttttcttatgaatataaacattctaaataaaacgaaatttagtagtaagggtagt
aaaaagaatatatcatgaccaagtagtgtttacaacaagaaagaaacagtaaaactgggg
aaaataattcaactaatatagtagcagattaaaaagaaaaaaataatttttcaatagatg
tcataaaaacatttgatacactgtaacactgaattttgataaaatatcttaagtgaaaaa
tcaaagaatgttttcttaactggacaaaatgactccctcagatatccacagcaagcatca
aatttaatttaaaatctatagaagtgttcctcctaaaactaagaagagaaagatgcctcc
tattatggctgctctaaaataaggtcctggaaatccctaacgattcagggatttcacgat
tcaaatccctacctaaaaagaaatgagaaatgaaaaaaagagagaaaagcctgtcattat
ttttgcaggtgacagaattgtatgcttagaaaatccaagaaaatcaactgaaaaattatt
cagactaatgagatagccagagataaatatataaaaatga ,
>IGR1109a
taaggtcctggaaatccctaacgattcagggatttcacgattcaaatccctacctaaaaa
gaaatgagaaatgaaaaaaagagagaaaagcctgtcattatttttgcaggtgacagaatt
gtatgcttagaaaatccaagaaaatcaactgaaaaattattcagactaatgagatagcca
gagataaatatataaaaatgaagttttattatctagaggcaaacaccaataggaaaggca
atagaaaaaaaaaggatcctattcacagtggcgataaaaaccctaaaatgcctaggaata
agtctaacaaaagggtataggagctagaggaaaaagctgtaaaactttacaataggataa
aaggaaatgattgagcaggagatgcatactaaggagtccagaatggtagatgtgatatta
caaagatgtccgttctcctcaaataatccataaattaaatgcaatccaaacagaaacccc
aataaaattaaaaaatgcttaacagaatccataagctgactctaaagttcatatagaaga
gataatacaaaagaaaaaaaataaattttaaaagttggtatacaaaggaaaatccagaaa
caaacccaaatgcatatagaacgttagtttataactgcaacagttcaaatcaactggaaa
gttttcaacagtgttacaaaagataaaaaaaaaattatta
>IGR 111 Oa
taacagaatccataagctgactctaaagttcatatagaagagataatacaaaagaaaaaa
aataaattttaaaagttggtatacaaaggaaaatccagaaacaaacccaaatgcatatag
aacgttagtttataactgcaacagttcaaatcaactggaaagttttcaacagtgttacaa
aagataaaaaaaaaattattacccgttatccaacctcaaaataaaatccaaatgaatgaa
aggattaaaagctaaagtatttgggcagctgaggtgggaggattgcttgagcctggagtt
tgagaccagcctgggcaacatagtgagatcccatctctacaaaaaaatttaaaaattagc
tgggtgtggtggtgagtgcctgtagtcccagctacttgggaggctgaggtgagaggatca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-209
actgagcccgggaagttgaagctacagtaagctgtgatcatgccactgcactccagcctc
ggtgacagagtaagaccctgtctgaaaaaacaaaaaacaaaaaacaaaagctaaggtaaa
ataaaacaatcagatgaaaacattttgataattttaggattgggaagcctttctaaataa
ggaacaaaattgagaagccataaatcaaaagactaaagatttgactacctaaaaattaaa
agttacaaaagataccataaagaaagctgaggcagctggg
>IGRlllla
gtctgaaaaaacaaaaaacaaaaaacaaaagctaaggtaaaataaaacaatcagatgaaa
acattttgataattttaggattgggaagcctttctaaataaggaacaaaattgagaagcc
ataaatcaaaagactaaagatttgactacctaaaaattaaaagttacaaaagataccata
aagaaagctgaggcagctgggtgcggtggctcacacctgtaatcccaacactttaggagg
ccaaggcaggcagatcacttgaggtcaggagtttgagaccagcctgaccaacatggtgta
accctgtctctactaaagatacaagaattagccaggcgtggtggtacatgcctgtagtcc
cagctactcgggaggctgaggcaggagaatcgcttcaacccgggagatggaggcggaagg
aagtaagctgagattgtgccactgcactccagcctggacgacagagctagactctgtctc
aaaaaaaaaaaaaaaaaaaagaaaaaacgaaagaaaattgatggacaaacgataaactgg
gaataggtacttgcaatgtatgtgaaaataattaacatctagaatctattaaaatgtgac
aaatcaagaaacagacaacctagtagaaaaactggcaaagagatatgaataggtaattct
tggagaagaaatacaaatagacaacatacaaaaagacatt
>IGR1112a
agaaaaaacgaaagaaaattgatggacaaacgataaactgggaataggtacttgcaatgt
atgtgaaaataattaacatctagaatctattaaaatgtgacaaatcaagaaacagacaac
ctagtagaaaaactggcaaagagatatgaataggtaattcttggagaagaaatacaaata
gacaacatacaaaaagacatttaacttcactagtaaagagggaaatgtaaattaaagtgc
aagctttttttgtgcagccaataaaatgtcagtaacaaaatccagacatggaatgggcac
tttcatatactattggtggaaattttctaagtgtttttagaaggcaatttggcattaact
aaaaaatatacataacatctgagccagtaactccatttctaggaagctgtctttttgaca
tatctgctttagtgtgcaaagacacactctgcagcattatctgtagtagcacatatttaa
aagctttctaatatgttcaatagtggttaaataaagtagatatcatgcattttacagaat
atgcagccattaaaaatacaaggtacttgaatatatgaacgtaaaagattatcaccacgt
taaatggaaaaaaaaactcagaaaaatatctaccttgtgataatgcttacaaagaacaaa
aaagatgtatttgggtgtactatgtgcaaagccattgtga
>IGR1113a
atagtggttaaataaagtagatatcatgcattttacagaatatgcagccattaaaaatac
aaggtacttgaatatatgaacgtaaaagattatcaccacgttaaatggaaaaaaaaactc
agaaaaatatctaccttgtgataatgcttacaaagaacaaaaaagatgtatttgggtgta
ctatgtgcaaagccattgtgagggaaatgaaaatatgtcaccaacttaataattcttaag
ggctgaatcaaagttagacactgtcatggaaatgagcctaagtctaccttgaagtgtgtt
ctgtggtttgcagttatggagcgtggggaagcccaaatatctgtaatacaaggctgaatg
gctttagttgtataagtggtacaaaatattattaagtacaaaggtaggaaaaaaatcaca
tatgtttgggaagggcttaatcaacataacattccaaggatgggagagatagcacaggaa
aatatgggacaaaattgtttggttagaacacacttggtagtaggaattgaaatgggaaag
cccaggtatggaagtcattcctaaaattagaagggaatagggaccaccagctttaggaaa
atgaagctggcagaagtataatgggtggaggtgggggtaggaaggacggtaagagataag
aggtgggaaaggtgccacggtaataggtgagagttactta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-210
>IGR1114a
tggttagaacacacttggtagtaggaattgaaatgggaaagcccaggtatggaagtcatt
cctaaaattagaagggaatagggaccaccagctttaggaaaatgaagctggcagaagtat
aatgggtggaggtgggggtaggaaggacggtaagagataagaggtgggaaaggtgccacg
gtaataggtgagagttacttaggctgaagccatggaaagaaggcagctctgggctgggtg
cggtggctcacacctgcaatcccagcactttgggaagctaaggtgggaggatagcttgat
cccaggaagtcaaggctgcagtgagctgtgatcatagcactgcactccagcctgggtgac
agagtgagatcctgtacaagaaccctataggagctattgagtgacatatagtggcccaat
taacttaacacgcttttatcacttggactttacaggcatttaacatcaaataacttacag
aatgaccttgaaagtccatgactgtctggtgaggcaaagatttgaatttcatgggctgca
aactgttatggtcaagtagccatctggctagtgtatcagctccaccacctgcctggagta
tgcacatctctcagttaaatgcatatactaactcatgcgaagtagtatgatttctttgtg
aaaactggctcttaaagtgagaggccaggtgaggtggctc
>IGRl 115a
gactgtctggtgaggcaaagatttgaatttcatgggctgcaaactgttatggtcaagtag
ccatctggctagtgtatcagctccaccacctgcctggagtatgcacatctctcagttaaa
tgcatatactaactcatgcgaagtagtatgatttctttgtgaaaactggctcttaaagtg
agaggccaggtgaggtggctcacgcctgtaatcccagcactttgggaggccaaggtgggt
aaatcacttgaggtcagatgttagagaccaccctggccaacatggtaaaactctatctct
actaaaaatacaaaaattagccggtgtggtggtgggcacctgtaatcccagctatttggg
aggctgaggcaggaggatcgcttgaacctgggaggtggaggttacagtgagccgagtttg
caagaatgaactccagcctgggtgacagagccagactctgtcttaaaaaaaaaaaaaaaa
aaaagtgagactctctcggagctcagaaaataatgatttataaattactttagtctgata
tttaaatactcattaagagtctgaaagatttcattaaaaatttcagtaacaatcgattgc
attttatgaggaaaaatgatggctttaatggcatttatatttctggtaatccatgaaagt
cttaacaagcttgtccagcctgccttattttgttgttctg
>IGR1116a
agctcagaaaataatgatttataaattactttagtctgatatttaaatactcattaagag
tctgaaagatttcattaaaaatttcagtaacaatcgattgcattttatgaggaaaaatga
tggctttaatggcatttatatttctggtaatccatgaaagtcttaacaagcttgtccagc
ctgccttattttgttgttctgttttgttctaggcttttagcagactgaagccatggtttt
tagttttgtctctagtgatgagcagaaaagagggatgaggaagaggctttactggtccaa
ccagaaagagaagctaagaacccatgactggattctctcccttggacaccccacagacca
atatctcaccttccaggagaagacccttccagctcttgcttctttaaacctattaactta
gttttctttagctagactcccaaacatcagcttttacaattcagcctatggttcaatcac
tatggcaagataaacatttgtttaggtgtgaaacaccactggctatctttgggttttgta
atctaccctcttgaggttgcaggagctactgtgaaaccttactgcatccatggtcatgat
agagatggtgactctaaggtgagccctgaataaagccctcatctgaagctcccctcgaat
gcagggacccaggctctgaagagcctcacagaaagctggc
>IGR1117a
gtttaggtgtgaaacaccactggctatctttgggttttgtaatctaccctcttgaggttg
caggagctactgtgaaaccttactgcatccatggtcatgatagagatggtgactctaagg
tgagccctgaataaagccctcatctgaagctcccctcgaatgcagggacccaggctctga
agagcctcacagaaagctggctaccttggatgcaaaactgtaaaggttacgtgtttacaa
tgagtcttaaaagaagcatgacctggccaggtgcgtggctcatgcttgtaatcccagcac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-211
tttgggaggccaaggcaggtggatcacaaggtcaagagatcaagaccatcctggccaaca
tggtgaaaccccgtctctactaaaaatacaaaaaattagccgggtgtggtggcaggcgcc
tgtaatcccagctacttgggaggccgaggcagaagaattgcttgaacccgggaggtggag
atggcagtgagctgagatcgcaccattggagtccagcctgggcaaaaagagcgaaactct
gtctcaaaaaaaaaaaaaaaagtattacctaatatgcaaccttccacatctggggaaaaa
tgagagtagaacattttgggcatggggtagaacaccatatcttgagtgatatattctaac
atcatttaaattggtatattgtattagtatggggtaatac
>IGR1118a
gcaccattggagtccagcctgggcaaaaagagcgaaactctgtctcaaaaaaaaaaaaaa
aagtattacctaatatgcaaccttccacatctggggaaaaatgagagtagaacattttgg
gcatggggtagaacaccatatcttgagtgatatattctaacatcatttaaattggtatat
tgtattagtatggggtaatacattccaaatgatggataatttcccccttttcatctatgt
gtctctgaccactgccaatgcttatacttagtgatgtttttagatgattactaataacag
atggtaatcagcttttcttgaaaatgcactgctgacttcctgtgttaccttaaatagaca
gctgaacgcaacaattacactgactgcatgctttattctaagacgtgaaagaatgaggga
aattttgtaccttactttcttctgggtgagaaggcaaatttagggctcaccgtataaatc
ttgagaaggccactgtttgcgagcataagccacaaagactcaattttggggaaatttgta
tcacctcttttcatttagaagaatccatctgagtaccaggtaagagaactcagtaaacag
cctggctttgttccttaacaagcctaaattgctagaaagcactcctgtacctctccaccc
cgccaggctccaccaagctccctcataggtcctcattctg
>IGR1119a
cgagcataagccacaaagactcaattttggggaaatttgtatcacctcttttcatttaga
agaatccatctgagtaccaggtaagagaactcagtaaacagcctggctttgttccttaac
aagcctaaattgctagaaagcactcctgtacctctccaccccgccaggctccaccaagct
ccctcataggtcctcattctgctcagcatgcctctgtgactgaggcacttttctctgctg
aaaagcccttccttcttatcccaggcccaggtcaaaaacagactatggagcacctaccaa
ggtctccatcagacagactgtcagcagtttggaggagggacagggaaagatattcctgtt
ttcccagagcctgacaagaaagtggcagagcaagggttgttgaattcttttttatttttt
ctcttatagcctaatcttggaagtgaagggaattcttattcctgctgccactggttctca
gggtatgcagggatagctggagagctcctacgtatgtttttctattcagtgaatacatat
gaaaccccaggtctgcaggtcaatgggctgtaagagaagagctgaccttgcagcaaaata
cttacaagtaaaattgaaaacaaaaccaacctgcctatttaacttggtccctggtccact
ctaaccattgccccatttttcttgctccccgtcacaggag
>IGRl 120a
gagagctcctacgtatgtttttctattcagtgaatacatatgaaaccccaggtctgcagg
tcaatgggctgtaagagaagagctgaccttgcagcaaaatacttacaagtaaaattgaaa
acaaaaccaacctgcctatttaacttggtccctggtccactctaaccattgccccatttt
tcttgctccccgtcacaggagaagttgttataagaattatctatattctctgtctccatt
tctttttcttttttttttctgagacagtttttttctcttgttgcccaggctggagtacaa
tggcacgatcttggctcactgcaacctccgcctcccgggttcaggcgattctcctgcctc
agcctcctgagtagctgggattacaggctaggcaccaccaggcccagctaatttttgcat
ttttagtagagacgtggtttccccatgttggtcaggctggtctcgaactcctgacttcag
gtgatccacccgccctggcctcccaaagtgctgggattacaggtgtgagccaccgtgccc
ggctgctgtctccatttcttactacccattctctccccacccaacttgaccgggcttcag
ttccaactgtgccactgactgctcctcagtcattaacaacttccattttgtcaaatttaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-212-
gggccacttcttagtccttatcttatttgactccaaatag
>IGR1121a
ctcccaaagtgctgggattacaggtgtgagccaccgtgcccggctgctgtctccatttct
tactacccattctctccccacccaacttgaccgggcttcagttccaactgtgccactgac
tgctcctcagtcattaacaacttccattttgtcaaatttaagggccacttcttagtcctt
atcttatttgactccaaatagcattagattcttgatatatttgcttcacttggttttcaa
gataccacatcttttaaaatcttttcccacatcaccagctgcttatttactggatttgca
aacataactagtggtgggacctttcccttctctctctatgctcattccacatgtgatctc
atctcatgggttaaatgccgtggatatgctgatgactccccagtgtacacctttcacttg
aactctaggctcgaggttatatatccaactgcctgcttgacagctctgcttagatatcta
caggcacttcaaacttaaagtgtacaaaacggaactactgattttctctccccagtccca
cccattttagggaatggcaacctgttctcccaatatcctgttgttcaagcaaaaatatgt
aggagcaacctttggttattttactttccctcccttacactcaattcagaagcaaggcct
gtcaactctctctccagaacaaatcccaagtctatcactt
>IGR1122a
gtgtacaaaacggaactactgattttctctccccagtcccacccattttagggaatggca
acctgttctcccaatatcctgttgttcaagcaaaaatatgtaggagcaacctttggttat
tttactttccctcccttacactcaattcagaagcaaggcctgtcaactctctctccagaa
caaatcccaagtctatcacttctctccattttcactgctaccacctgatctagcccacca
ccatctcttggttactacaagtctcctcatcagtctctgcttttactcttgccctttaca
atccattctccacacccagcagccagtgcaatttcttccaactagaaatcagattatatt
acttccctgcttcaaaccctccagtgactgcccaatgcagttagaatgaaataaaactgt
ttgtttaccaaggctacaaggcatgacatactctgggaatggtctatccctgactatatt
ccacccatgcttgccttcttcctggtccttgaacactttctgttcgtactggtcttggct
gctgcagtaactattctctctacctggaacgcctgcaccccattttttgcatatcttgct
cccttctcatcaatcaggtcccagcttaaaggcccatctgttatgctcacattgttcatt
ttcactgtaatacctaccactactacccattttgttatta
>IGR1123a
tcctggtccttgaacactttctgttcgtactggtcttggctgctgcagtaactattctct
ctacctggaacgcctgcaccccattttttgcatatcttgctcccttctcatcaatcaggt
cccagcttaaaggcccatctgttatgctcacattgttcattttcactgtaatacctacca
ctactacccattttgttattaatttatttcttaattttgtttcttcatccttatatactt
agtatctagaacagtatcaagcatttatgtactcaaatttttattgaacaaaatcctaat
atacaactatgtattatgtacacaagcacctcactgaagagttacaaaatatatagaaat
aagttatggttctaaaccaggaagtataagtaacagttaaaatgcttttatataaatact
agttttttaacggttataaaaaaaggtcatgcccgtaatcccagcactttgggaggctga
ggagggtggatcacttgaggccaggagttcaaaactagcctggtcatcatggcgaaacct
cgtttctactaaaaatacaaaaattagcccagtgtggtagcacatgcctgtaatcccagc
tacttagaaggctgaggcatgagaatcgcttgaacccaagaggcagaggttacagtgagc
agagatcacgccactgcactccagcctgagagagctgaga
>IGR1124a
gccaggagttcaaaactagcctggtcatcatggcgaaacctcgtttctactaaaaataca
aaaattagcccagtgtggtagcacatgcctgtaatcccagctacttagaaggctgaggca
tgagaatcgcttgaacccaagaggcagaggttacagtgagcagagatcacgccactgcac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-213
tccagcctgagagagctgagagaaccagtgagactccgtctccagaaaaataaaaaaaaa
agcagggggccactatggtagcagcatgtcacagtggttctgatatctaattttatctct
accatttacctgggtaatcttgggtagcctgcttaatctgtctgataaatacttgccctt
taaaacagagttagatacaataattaaatcgattatgctatcatgtagtattcaattgct
attattgtcttctatgcacagccctcaacctcaaagaatgtttaaatgggaacagaaacc
tacgttttcttaatgaatttagttctttagtgctattaaagaatagagaatttaagaact
taacttacattaaagaatggaacatgacaaaggaagctggactaaatcgcctctgagctt
ttctgactctatactgaataatagtatagatttttaaaaattctattttatagatgagga
aacggaaactcagagtgtctaaataatttgctaaatatct
>IGR 1125 a
tagttctttagtgctattaaagaatagagaatttaagaacttaacttacattaaagaatg
gaacatgacaaaggaagctggactaaatcgcctctgagcttttctgactctatactgaat
aatagtatagatttttaaaaattctattttatagatgaggaaacggaaactcagagtgtc
taaataatttgctaaatatcttcagtcaggactcaaaatcaccactatggagaatagtat
ggaggttcctaaaaaaactaaagacagaactaccatatgattctgcaatcccacttactg
gatatttacgcaaaggaaatgaaatcattaggttgaggagatatctgcactcccatattt
attgcagcactgttcataatacctaagatttggaagcaacctaagtgtccatcaacagat
aaatggataaagaaaatgtggttcctctcgggcgcggtggctcacgtctaattccagcac
tgtgggaggctgaggcgggtggatcatttgaggtcaggagttcgagatcaatatggccta
catggcaaaaccctgtttctactaaaaatacaaaaattagccaggtgtggtggcaggaac
ctgtaattccagctactcggaggctgaggtggaggttgcagtgagctgaaatcacaccac
tgcacttcagcctgggagacagagactccgtctcaaaaaa
>IGR1126a
tggatcatttgaggtcaggagttcgagatcaatatggcctacatggcaaaaccctgtttc
tactaaaaatacaaaaattagccaggtgtggtggcaggaacctgtaattccagctactcg
gaggctgaggtggaggttgcagtgagctgaaatcacaccactgcacttcagcctgggaga
cagagactccgtctcaaaaaaaaaaaaaagttgttcatatatacaatggagtgctattca
gccataaaataaaatgagatcctgtcatctggaataacatggatggaactgaaggacatt
atgttaggtgaaataagccaggcacagaaagacaaactttgcatgttctcattcatttgt
gggagtgaaaaattaaaacaattgaactcatggagatagtggagatgatagttaccagag
actaggaagggcagtggagatggttaacaagtacaaaaatatagtaagaataagatctag
tatattatagcacaacagagtgactacagtcaacaatgtattgtacatttaaaaataact
aaatagtataattggaatgtctgtaacaaaaggaaggataaatgcttgaggtgatggaaa
cctcatttaccctgatgtgattattatgcattgtatgcctgcatcaaaatatctcacgta
ccacataaatataccggctatatagccataaaaaataaga
>IGRl 127a
gtgactacagtcaacaatgtattgtacatttaaaaataactaaatagtataattggaatg
tctgtaacaaaaggaaggataaatgcttgaggtgatggaaacctcatttaccctgatgtg
attattatgcattgtatgcctgcatcaaaatatctcacgtaccacataaatataccggct
atatagccataaaaaataagaataaaactttttttaaaaaaaagaattcggccgggcgcg
gtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcggatcacgaggtca
ggagatcgagaccatcccggctaaaacggtgaaaccccgtctctactaaaaatacaaaaa
attagccgggcgtagtggcgggcgcctgtagtcccagctacttgggaggctgaggcagga
gaatggcgtgaacccgggaggcggagcttgcagtgagccgagatcccgccactgcactcc
agcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaagaattcaaaatctgg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-214
acatctgtagtgttcagagacagcacttttaaccatgtattatggacttctgaggctttt
taaaaaaggtaaaacttatcatgttggacttttatacaaagtccaatgtcttgcttttaa
tatccatttttatttttccatcacaaccaacttatcttat
>IGR1128a
gactccgtctcaaaaaaaaaaaaaaagaattcaaaatctggacatctgtagtgttcagag
acagcacttttaaccatgtattatggacttctgaggctttttaaaaaaggtaaaacttat
catgttggacttttatacaaagtccaatgtcttgcttttaatatccatttttatttttcc
atcacaaccaacttatcttattccaaatagaagttttggtgatttttttttttttttttt
ttttgagacagggtctctttctgtcacccacgctggagtgcactggcacaatcttggctc
attgcaacccgccacgggcttctgagtagctgggattacaggtgtgtgctaccacgccca
gataatttttgtatttttttgtagtgatggggtttcgccatgttgcccaggttggtctca
aactcctggacttaagcaatccacccactttggactcccaaagtgctaggattacaggcg
taagccactaagcctggcaaaataggtttttaccaacaaaaatctgttttgatttgtgtc
tcttcaaataaactataatatccttgctagaagttactggatctcctattccttaatgct
caatgaatgtttgataagtctattagatacacagcatctgttgttaaagaactaagaaaa
actaaaaagtcccctaaaggcataaatgaggtagctgaga
>IGR1129a
aaataggtttttaccaacaaaaatctgttttgatttgtgtctcttcaaataaactataat
atccttgctagaagttactggatctcctattccttaatgctcaatgaatgtttgataagt
ctattagatacacagcatctgttgttaaagaactaagaaaaactaaaaagtcccctaaag
gcataaatgaggtagctgagaagactaaaaagaattattaaaggcaaaaaaaaccaaaaa
acaaaaaacaaatatatgtatgtgtagtctactgggcaagaattccttaagttttgctta
tgttcttgtttcagcaccttaaattccaagactaaccactttaaactgctggatctaata
tctaggagagatggcaatattcaaagaagttaaaaaacaaaagttctcatttggtgcagg
catataattctatgagccattttggacccagggaacattgtaatgttaacgtacccactc
acaatgaaatgggacaaaagatatatccatggaatactctcaaaaaattgttttaaaagt
taaacttaatctaacaaaaatcttagtataatttatttttaaaaaataacatgttaattg
gctcactcccaatatttcacagtaaatggatctaatttgtcttacatgattacgtacttc
ctaaaacttgtatatgccaaaaatatgcctaggcaattct
>IGR1130a
gatatatccatggaatactctcaaaaaattgttttaaaagttaaacttaatctaacaaaa
atcttagtataatttatttttaaaaaataacatgttaattggctcactcccaatatttca
cagtaaatggatctaatttgtcttacatgattacgtacttcctaaaacttgtatatgcca
aaaatatgcctaggcaattctgggaccacctttgttatcatcactaactaaaaaagtcct
catactgaaaccagagttctcctgtcttcctgagccctgtggtctgaatgccactgctca
ggttggtctgttgactatgctgtatctgaccagaagtcttagaagagaagctctctgtgt
aactctcttagtgctaaggaagatatttgccattctggaaaaaacaaccaccaccaaaat
ctaaggtaagtaataattctcctgccacaaatgaacagaactactagatagacttataac
aaaacttattttaaattcatagttgagctcacaagaaagaaagggaaatccctacataat
agaaacgaagatagaagtgaaaaccagaccagtcagtatgtaacctgacagacaaactaa
acttggggttattattattactgttattgttagttttgagacagagtctcgttctgttgc
ccaggctggagtgcagtggtgcaatcttggctcactgcaa
>IGR1131a
tagttgagctcacaagaaagaaagggaaatccctacataatagaaacgaagatagaagtg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-215
aaaaccagaccagtcagtatgtaacctgacagacaaactaaacttggggttattattatt
actgttattgttagttttgagacagagtctcgttctgttgcccaggctggagtgcagtgg
tgcaatcttggctcactgcaacctctacttcccagttcaagcgattctcctgcctcagcc
tcctgagtagctggcattacaggtgtgcaccactacagccagctaatttttgtatttttt
ttagtacagacggggtttcaccatgttggccaggctggtcttgaactcctcacctcaagt
gatccgcccacctcggtctcccaaagtgctgggcttacaggcatgagccaccgtgcccag
ccatgaacttggcgttattgtttttataacctagggattggttcttatcatccaggacag
aagatgaaggataggacccaagtaaggaagaagattagaagtgactcccaacacacaaaa
aatgggactcttcaagagctataacatcaatcctcaatgaaagagtggaaaattaatgag
ttgaaaattcaaagtcttgggcaaatgctttatatagttttggggttcaaagttatgcta
ccagtgagtatagtctaggaacctaccaactaagaaatta
>IGR1132a
aagtaaggaagaagattagaagtgactcccaacacacaaaaaatgggactcttcaagagc
tataacatcaatcctcaatgaaagagtggaaaattaatgagttgaaaattcaaagtcttg
ggcaaatgctttatatagttttggggttcaaagttatgctaccagtgagtatagtctagg
aacctaccaactaagaaattaacaaaaaccctacatgcaggccaatgttttctctggagc
tcttagttaatataaaaccaaaatttctgtgtagatggacctctacaaggaaaggtcaca
agggagtctcatagaaaaaacaacactactaaagataagcacacaattaaatgttaataa
aacacagaaacttcactaggggatagaatcaacatacaaaacagcagaagcagactcctc
aaaatgtgaaattaaaaaataacaatctgaaagagaatataaaatgtgtatagttaaaat
gagtaaagacacattcaagaaggaatcaaaatactaaggaagaaaatacatcataagcct
ggcacagtggctcacatctgtaatcctagcactttgggaggcctaggtataaaatgtgta
taaaatgagtaaagacacattcaagaaggaatcaaaatacaaaggaagaaaatacatcat
aggcctggcgcagtggctcgcatctgtaatcctagcattt
>IGR1133a
aaggaatcaaaatactaaggaagaaaatacatcataagcctggcacagtggctcacatct
gtaatcctagcactttgggaggcctaggtataaaatgtgtataaaatgagtaaagacaca
ttcaagaaggaatcaaaatacaaaggaagaaaatacatcataggcctggcgcagtggctc
gcatctgtaatcctagcattttgggagacctaggcaggaggatcgcttgaggccaggagt
tcaagaccagccggggcaacatgacaaaaccccatctgtaataaaaatacaaaaattagc
cgagtggtggcatgcatctgtaattccagctatctgggaggctgaggaatgagaactgct
tgaactcaggaggtggaggctgcagtgagccgagatcatgccactgcactctagcctggg
cgacagagccagactctgttttaaaaaaaaaaaattataaaaaaaccatgtgagtttctg
aaaaagaacaaaatagaacttatagaaaaaaatggaggaaaaaatgacaactcaataggc
agtataagtagcagctaaataatttatttaacaagatatttacccagagcccagtatatg
caagaggggttaagcaatgtagaggaaagaggaggttatgtctaataaaaagtgaagaag
gggaaaatagtgagaaatggagaaagaataatatttgaag
>IGR1134a
ttatagaaaaaaatggaggaaaaaatgacaactcaataggcagtataagtagcagctaaa
taatttatttaacaagatatttacccagagcccagtatatgcaagaggggttaagcaatg
tagaggaaagaggaggttatgtctaataaaaagtgaagaaggggaaaatagtgagaaatg
gagaaagaataatatttgaagagataatgtatgaaaaatccccaaaattgatggaagata
tcaatcctcagatcaaaaagcataatttatgagcagaagaactaaagctgagtctagaca
cactattataaaaatacagaacactgaagacaaagggaaaaatcctaagagaaccagggg
aaaaaggcagattacttttaaaggaataattaaaatgatttctcaactgtaaccatagag
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-216-
gccaacaaaaaatgaaatattttcaaagtgccaagagaacaaaactgtcaatctagaact
ctatgctcagctaaactatcaaattaaggggaaaaacttctcaaagactgattgtttacc
actaacagtcattcactgaaaaaactattgaagaatatactccaaaaaaagaaaactgaa
cctaaagaagggaggagtgggatttaaaaagcaagaatgaacaaagaaattgggaaacat
gcgggcttatgaaaccaccacaataattattactcatttg
>IGR1135a
caaattaaggggaaaaacttctcaaagactgattgtttaccactaacagtcattcactga
aaaaactattgaagaatatactccaaaaaaagaaaactgaacctaaagaagggaggagtg
ggatttaaaaagcaagaatgaacaaagaaattgggaaacatgcgggcttatgaaaccacc
acaataattattactcatttgtgatgatttaaaaacaaggtaaaactaaaatattagaca
aaagaaataatgcagatgagagaagataattagtattcaggaaaaagataaaacaattca
cattaaagctatggtttttaaactttgatgtgcatcagaatcacccaaaatgtctgtcaa
aaatagactgctgggccctacctctcaaatttttgatcgaggtctggggtagaagctgag
aggcatttctaacatgttccaaggtgatactgataatggtgctccacgaccactttgaga
actaatgcatatgattttaagtcaaataagtatttaaaaattaaaaagtaaacactcaaa
taactaaagtagaatacaaccgatccttgaacacaggtttgaaccatgtgggtctatgtt
tatgtagattttcttccacctctgccatccgagacagcaagactgacccctcctcttctt
cctcctcctcttcaatgtgaagaggacaaggatgaagacc
>IGR1136a
agtcaaataagtatttaaaaattaaaaagtaaacactcaaataactaaagtagaatacaa
ccgatccttgaacacaggtttgaaccatgtgggtctatgtttatgtagattttcttccac
ctctgccatccgagacagcaagactgacccctcctcttcttcctcctcctcttcaatgtg
aagaggacaaggatgaagacctttatgatgattcatttccacttaacagaaaatatattt
tcccttataattttttcttgtctccagtttactttattgtgaaagaatactgcatataat
acacataacatacaaaatatatgttaatcaactgtttctgttatcagtaaggcttccagt
caacagtaggctattagtagttaagttctgagggaatcaaaagttatatgtggatttctg
actgcgtggggggcttagtgtccctaatccccatgttatatggtcaactggataacccaa
agaagggaaaaaggaggagtcaagaaaaataaatccatctcaaaaaggcaggaaaggaaa
aaaagatggcagaaataaatccaactcaattgagtaatcagaatgaatatgaaaggccta
aattcactggttaaaagacagacatacactggataaagaaaattctgctatatgtaatta
agatggtgagagaaatggcacagagatagacaaagtgatg
>IGR1137a
tcaagaaaaataaatccatctcaaaaaggcaggaaaggaaaaaaagatggcagaaataaa
tccaactcaattgagtaatcagaatgaatatgaaaggcctaaattcactggttaaaagac
agacatacactggataaagaaaattctgctatatgtaattaagatggtgagagaaatggc
acagagatagacaaagtgatgaattaagtagaacagagaacccaggccaacccaggcaca
tagggaattctgatatatgacagaaatgacactgtaggtcactgagagaaggatagtcta
caataaatagagccaagacaaccagttattcataacggaaaaaattcaacttagaattaa
atacttaaatgtacttacatgtgaaaggcaaaatttaaaacttttagacaaaaatataga
agtagggcgtggcagctcacgcctgtaatcccagcactttgggaggccaatacaggtgga
tcacgaggtcaggaaatcgagaccatcctggctaacacggtgaaaccccatctctactaa
aaatgcaataaaattagccgggcgtagtggcgggcgcctgtagtcccagctactcaggag
gctgaggcaggagaatggcgtgaacctgggaggcagagcttgcagtgagccgagatggcg
ccactgcactccagcctgggcgactgagtgagactccgtc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-217-
>IGR1138a
agaccatcctggctaacacggtgaaaccccatctctactaaaaatgcaataaaattagcc
gggcgtagtggcgggcgcctgtagtcccagctactcaggaggctgaggcaggagaatggc
gtgaacctgggaggcagagcttgcagtgagccgagatggcgccactgcactccagcctgg
gcgactgagtgagactccgtctcaaaaaaaaaaaagatatatctctctctctctctctct
atatatatatatatctttatatatatatatctttatatatatatatatagagagagagag
agagagagaggagtagagagagagagagagagagagagagaggagtagggaaggatttct
taacaagacacacaaagagctaaccagaaaaggctgctaaattcaactaactcaaaatca
aatccagtgtcatcaaaagatgctaagtaaaaaagataagcataatgtttgaaaagacat
ttgtaatacatataactgaaaaggaattgaaatgcagaagagataaagaacacatttaaa
tcaataagaaaagaccaatagggccaggaacaatgcctcacacctgtgaccccagcactt
tgggaggccgaagtgggaggaatgcctgagcccaggagtttgaggttacactgaactatg
attgcaccattgcactctagcctaggtgacaaagagagac
>IGR1139a
aaaggaattgaaatgcagaagagataaagaacacatttaaatcaataagaaaagaccaat
agggccaggaacaatgcctcacacctgtgaccccagcactttgggaggccgaagtgggag
gaatgcctgagcccaggagtttgaggttacactgaactatgattgcaccattgcactcta
gcctaggtgacaaagagagactctgtcccaaaacacacaaaaagacaagactaataatgt
ataaacaacgattcatcattttaaacctatgaggttggcaaacattaagaaatttataaa
accaatgtcagaggatccatcaaataaacccttatatactgctagtggtataaatcagta
gtcatttctggaaaacaatattattttgtaaaattgagcatactccacaatgcactccca
caaatataaccttatacctttcctccagaagacatgacaagacctggaaaaaaaccccaa
atgtccatctgtaggagaatgaatgcattgtggtctattcccatagtagattatgtacat
cagtgaaaatgaatcaactacggccataaacaacatggataaacaaaagcaaatccaaat
aaaaaagcaagtcctagaatatcatatcatttttaaaaagctcaaaatatgacatatata
tgataaaactgttttttaaaaaagcagagaaagtaaaaat
>IGR1140a
tgaatgcattgtggtctattcccatagtagattatgtacatcagtgaaaatgaatcaact
acggccataaacaacatggataaacaaaagcaaatccaaataaaaaagcaagtcctagaa
tatcatatcatttttaaaaagctcaaaatatgacatatatatgataaaactgttttttaa
aaaagcagagaaagtaaaaatctttgtcactggttatagggaatggggatgacagaaggt
tgagataagaagggagcatctaagtggatgccaatcagtgataatggtagattggttaga
gggaggtagtatcatgaatactcgtagatattaatatgctttatatcttaacttcataac
ttaagctagtgtgtgtttacatacatacatacatatattttccaatccatggtatacata
aaataccatatttaaagagaaaaaatgaggggctgggcgcagtggctcatgcctgtaatc
ccagcactttgggaggccgaggcgggtggatcacctcaggtcaggagttcgagaccagcc
tgancnacatggngaaaccnngtctctactaaaaatacaannattagcnnngcgtggtgg
cangcncctgtaatnccagntacttgggaggntgaggcagnnnaatcnnttgaacccggg
aggcagaggttgcagtgagcngagatngtgccattgcact
>IGR1141a
aggcgggtggatcacctcaggtcaggagttcgagaccagcctgancnacatggngaaacc
nngtctctactaaaaatacaannattagcnnngcgtggtggcangcncctgtaatnccag
ntacttgggaggntgaggcagnnnaatcnnttgaacccgggaggcagaggttgcagtgag
cngagatngtgccattgcactccagcctgggnaacaanagtgaaactctgtctcaaaaaa
nnntaaaannnnnaagaaaaaaagaaaaanannnnanaanngnnnannaannnannttnn
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-218
nnnatntnaantgcantannnaaatccccagtctaatacttactggtcaagagtcttata
ataaatatccagatccttgttcacaagttctgttgtcctcataacaatcatcatttctct
atacttttcctcagcatcccgaaattgtggttctcgaagttctttcttaaaatgaataat
ttcttcttcataacctttctgtcgccctaatgccaaattatgatttctttttatattgtc
tatgttctcttccaacttctgatgttcactgtaaaaaagaaaaatgacaaatgaggacca
ttttttagcttttaacaacctgaagtggaaaagtcatagatttctttagataggttaagt
atcattctccttagcaatcagtatattataacagagtctc
>IGR 1142a
tgtcgccctaatgccaaattatgatttctttttatattgtctatgttctcttccaacttc
tgatgttcactgtaaaaaagaaaaatgacaaatgaggaccattttttagcttttaacaac
ctgaagtggaaaagtcatagatttctttagataggttaagtatcattctccttagcaatc
agtatattataacagagtctctccttgcttattatttagggctttggtactaaagaaaac
ccctctcttccttccatatctctgccgcacataggttgctaaatagctaattttgtgtat
tacagaaccctcatagcatgtgatcactgataaagttcctggcctttagacgctaagtaa
agcactctggtgattaatattacaaattcacaatcttctgattgtgaactgagaatgcac
aattatcaacactaagaagttatggataacaggcttcatcatcattttgctcatgtcaaa
ggcacaatacgaattaaatcatatattaattttctgcagtaatacttattaaaaatttag
attcctccatgaaaacaaaatttctcttgcacaagtgtaaaaaccataataatgaccaaa
aaagtaaaatattcaaacttttctgatattttggcagattatacaaatttcaatgtatgc
tttaaaaatcttcatttatttattatcacttattaagcat
>IGR 1143 a
catatattaattttctgcagtaatacttattaaaaatttagattcctccatgaaaacaaa
atttctcttgcacaagtgtaaaaaccataataatgaccaaaaaagtaaaatattcaaact
tttctgatattttggcagattatacaaatttcaatgtatgctttaaaaatcttcatttat
ttattatcacttattaagcatcctcttatgtgtcaggcactactctcaagcttatgggca
tccttacagagtcgactggattacaagtcttgttggcatttctgttatgtcctggttgaa
gaaacgtttgaaaaatagttgtacttagtaatgtgaatgaatgtaaaaagtactgttatg
taccaattacagaagaaattttttaaatatctggttttggtctttagtagccacgaatat
attattttatatcaaaatttcttctagaagcattacttttccaacttgccatggagagta
tcgtgtaaaagaactgaggcttgggaactaggatattagggtcacattcttggctttcat
cataatttcctctgtgatttttctgggtctaagtgtgcataatgcatacaaaaatgaaga
ctctgaagatgatgagctcttctagttaaaaatctgatttccctgatataggaaagagat
tttaaatagctaagagtacttaaccaaaacacaggattaa
>IGR 1144a
cttgggaactaggatattagggtcacattcttggctttcatcataatttcctctgtgatt
tttctgggtctaagtgtgcataatgcatacaaaaatgaagactctgaagatgatgagctc
ttctagttaaaaatctgatttccctgatataggaaagagattttaaatagctaagagtac
ttaaccaaaacacaggattaaccatttgttaggctttataaattaaaattcactttacta
tatcctttagaaaagcctgggcattttttcattcagatttctgtataaattcaagaagac
atgaaaactctacaaggaagggtttaataaatgagaggcctggatttaaccagctgaggt
ggttgacaatctaagtatttgcctagtacaaccttttataccagtctagtgccttagcat
caacaaggttcttacagaattcctaaggcaactaactctaaggcagtcaaggcaggaata
aaatcttttctgctgtaccaggaaggtagcaactacaataagtaacaataagaccagata
aaggaagaatgaggctcatctttcaaaagaaatgctctggtggacacataattacaaatg
agaaaatctaaaatgaatctctgtggataaatcactctggcaacaactccattgacaata
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-219
ttatagactgtacaagctctgacccagacaaggtccacag
>IGR1145a
aggaaggtagcaactacaataagtaacaataagaccagataaaggaagaatgaggctcat
ctttcaaaagaaatgctctggtggacacataattacaaatgagaaaatctaaaatgaatc
tctgtggataaatcactctggcaacaactccattgacaatattatagactgtacaagctc
tgacccagacaaggtccacagctccatattctttatgcttagtaccactattctgtgcag
caggctagcagatgtatgggggctaagcatgttcaatactgaataactaaggcccatcac
tacagtgtgattaccaattctatatcacttcttcagtaataaagttcttaaggccatgaa
atataattgtatcaaaacactgttcaccttctagtaactctcaaaggataccaggctgag
gctaaaattcttttaaaacaggtatttaatattcttcacattccagtaataaagacgttt
atttaaactgaagattattttaaaagcataccttttcatttgcaaaacctgcatttgacc
catttccttcaaatgttgttttctttcttcttcaacttcttttagttcctcatttctttt
tcttaaagtaaggttatcttgtagccacctttcttgtatctaaaggtaaacattaaatta
gttaacaaaaataaccaagttactaacatgaaatctgtaa
>IGR1146a
ttaaaagcataccttttcatttgcaaaacctgcatttgacccatttccttcaaatgttgt
tttctttcttcttcaacttcttttagttcctcatttctttttcttaaagtaaggttatct
tgtagccacctttcttgtatctaaaggtaaacattaaattagttaacaaaaataaccaag
ttactaacatgaaatctgtaacaggcaactggtgacagcaagtgccatttctgtcttact
tagaatcatgtgaaattcaacagagggagaataagccagtgtgaaggaatctacaggtct
ggggcaatctggatggcccatccccatccacagtgacaagtgtaatacctcctgtagcgc
agcttttactgctctttcacaaccataatctaaaaaccaggtctactgtttgatggggag
tctcataaagatttgagcatatatctgtgtacttatttacttataaagtattaaaaacat
acaaaacagacattttaaatggtgaaattaaaaatataactagatattttaatacctaca
tccccagtggatcattttgcataggaaccccatgataaagcctactgacctgaaagatta
taagagatcaatactactactgaagtcttccccaactttttcgtcctagttctgtctccc
aacatgtaccaagaccattagaacctgttaggtatatgtt
>IGR1147a
tggtgaaattaaaaatataactagatattttaatacctacatccccagtggatcattttg
cataggaaccccatgataaagcctactgacctgaaagattataagagatcaatactacta
ctgaagtcttccccaactttttcgtcctagttctgtctcccaacatgtaccaagaccatt
agaacctgttaggtatatgttacctgcaacttctacctttaggttgacaaattgtaatca
ctcaaggcagtaagaagtgccacaatagtagcatatatctatgaacttggtacctcctta
gccaccgaaatgaaatttcaaaaaattggctgttcttgttgagtagttttgtccttcaaa
agagactcaataacacttagcagcagcagcaacaacaacaaaattatttcagtggttttc
ctggtgattaaaatgaactatgttgtcaagagacaatcattagaaaacagtttttaagtt
gattctttggaatttagaggaaaaaaaatttcctgcagaaagaagggtgatttggcccac
aaatcatgtgtatagaaaacttattctgaatttggagtaaggatttctcaaagagggagc
tgggaccctcctgcaatagcccttgcagctaagctaaactcagtgacatgggaagtgaga
gagatggacagacctgtggcaatatcttgcaccaacagta
>IGR1148a
gaaaaaaaatttcctgcagaaagaagggtgatttggcccacaaatcatgtgtatagaaaa
cttattctgaatttggagtaaggatttctcaaagagggagctgggaccctcctgcaatag
cccttgcagctaagctaaactcagtgacatgggaagtgagagagatggacagacctgtgg
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-220
caatatcttgcaccaacagtaaaggccagggactggtagatgagagagggaaatcaagga
tttctctcacatgcttaatgttcatatccaatcctgcccctctatgcgtgactattttta
gagttttttttttcttttttaacagtcacaaagtaaggctactttcatttttcctggaaa
taatataaacatacaatttatccacagggtccacatctacggattcaactaaccatggat
caaaaatattggggaaaaaaaataaaaagtaatagtacaataaaaaaatacaaatttaaa
ataatacaatataaaaactacgtatcatttacatattaatatcaaaagcaatctagagat
taaagtatatcagaggatatggataggctatatgtaaacactagatatgccattttatat
aagggacttgagcatcctagatttcggtatctgttttatcgggggatcctggaaccaatc
cctcccagagataccgagacaactgaatatgtatctacta
>IGR1149a
acgtatcatttacatattaatatcaaaagcaatctagagattaaagtatatcagaggata
tggataggctatatgtaaacactagatatgccattttatataagggacttgagcatccta
gatttcggtatctgttttatcgggggatcctggaaccaatccctcccagagataccgaga
caactgaatatgtatctactaaaggcattattataggcagttaaaggtgactaaaatgac
atggttataaatgtcctttgttgctaaagcaatctaatgtaccactgtagctggtgtgac
ttaccaaggttctactatggggtactatgcttgttgttccttattaggaacaagggaatg
tgctactgcttactttcatctaataccccagaacatttgaatttgttttcacaattgcat
gaaaggactctttaaagtgctatcacatttttagatgagactgatttttggcacaaaata
ttgttgctggtctgtctacctgcattgttaccagacagctaggcatttctttgttttagg
tcagcttccattattcttctagttttgaaagacagtatataccacatcaagagtgtaatg
ctttgaagtcagatacatctaggctcaaatcacagtgttattacttttaaactggataac
tttgggcaaattagtttaaattctctgaacctcagtttgc
>IGR1150a
ctgcattgttaccagacagctaggcatttctttgttttaggtcagcttccattattcttc
tagttttgaaagacagtatataccacatcaagagtgtaatgctttgaagtcagatacatc
taggctcaaatcacagtgttattacttttaaactggataactttgggcaaattagtttaa
attctctgaacctcagtttgcttataacatggtcaataatgatactatctatcataaaga
actattgtgtggccgggcgtggtggctcatacctgtaatcccagcactttgggaggccaa
ggcagatggattacttgaggtcaggagttcgagatcatcctggccaacatagtgaaaccc
cacctctactaaaaatacaaaaattagccaggcctggtggcactcgcctgtagccccagg
caggttgaggcaggagaatcacttgaacccgggaggcgaatgttgcagtgagccgagatt
gtgccactgcactccagcctgggtgagagagcaagactccatctaatttaaaaaaaaaaa
aaaaaaaaaaaagactattgtgaagattaaaggaatgagtgtatgtaatcagtatagtgc
ctgactcaataattgctaataaaatgccttttgggtcaaatttgtcctttgtactgtaag
cagtgagaattccaattatagtctacaaaatgtatcagag
>IGR1151a
tgggtgagagagcaagactccatctaatttaaaaaaaaaaaaaaaaaaaaaaagactatt
g2gaagattaaaggaatgagtgtatgtaatcagtatagtgcctgactcaataattgctaa
taaaatgccttttgggtcaaatttgtcctttgtactgtaagcagtgagaattccaattat
agtctacaaaatgtatcagagaaaggaagggaaaaaaaatcagatgcagttatagtatac
cacaaatgtttttccattctactagaaatttgatagtgtagggtccagttctacctgtta
ctactttttgtgaccttggacaagtcaggtcacctacagttctcttcatatattccttca
gctgaaaactgagaaaggcagttaagtttccaaattattttattctgtggactaaattta
gcagggcttaaatcagtacgtaaataagtgactgttaggctcctcagctcttaaatatta
accccaatcatccaactcagatgacagttaatgcatgcagctggtcacctatggaaacat
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-221
aaaaattagctgcattctagatacctgtgagagagtggcatgctgaacagattacagtcc
aatgtccaccaaaagtctagctgggaataacaccacttctacaagactgcctgaaagcta
tgcagtccatccagtgctggctcagttattgacagctaaa
>IGR1152a
gatgacagttaatgcatgcagctggtcacctatggaaacataaaaattagctgcattcta
gatacctgtgagagagtggcatgctgaacagattacagtccaatgtccaccaaaagtcta
gctgggaataacaccacttctacaagactgcctgaaagctatgcagtccatccagtgctg
gctcagttattgacagctaaagggatatattagaacctctaaggaatttcaacaaaacac
acatatctctgcccaaacccccaagattctgatttactggtgtggattggagacatagac
atatatatatatatattttttgagacagggtcttgctctgttgcccaggctggagtgcag
tggcgtagtaagggctcactgcagccttgaactccccagctcaagcaatcctcccacctc
agcctcctgagtagctgggactacaggtatgcaccatcacacctggctaatttttttgta
gagatggggtttcgccatattgcccaggatagtctggaactcccaggctcaagcaatctg
cccgcctcggcctcccaaagtgctaggattacaggcatgagccactgtgcccggccaaca
catgtatttttaataacctaagtcattttttaaaaactgagatgtaattaatattccaca
aaattcactgtttaaacgtgtacaatttagcagttttact
>IGR1153a
ttgcccaggatagtctggaactcccaggctcaagcaatctgcccgcctcggcctcccaaa
gtgctaggattacaggcatgagccactgtgcccggccaacacatgtatttttaataacct
aagtcattttttaaaaactgagatgtaattaatattccacaaaattcactgtttaaacgt
gtacaatttagcagttttactttatttacaaggttatacaaccatcaccactatccaatt
ccagagcatttgatcatcccaaaaggaaatctcatattcaatagcagtcactctattcct
tcctcacctctagccccctggaaacattaatctgctgtcactggatttacctaatctgta
catttattataagtggaatcgtacattatgtgaccttttgtgactggcttcttttgctta
gcatgttttaagggttcattcatgtggtagcatgtatcctttttatggctgaataatatt
ccattgtatgggtataccacattttgtttatctgatcatcagttgatggccatttgggtg
tgtccatattttgactattacaaataatgctgctatgagcattcttgtacaagttgttgt
gggaacatatgttttcaattttcttagttctatacctagaagtggaaaaactcagacgat
ttacaggtgcccctagctaagaacctttgctttctaaaca
>IGR1154a
cattttgtttatctgatcatcagttgatggccatttgggtgtgtccatattttgactatt
acaaataatgctgctatgagcattcttgtacaagttgttgtgggaacatatgttttcaat
tttcttagttctatacctagaagtggaaaaactcagacgatttacaggtgcccctagcta
agaacctttgctttctaaacattaacatttacttcaggcttcaatcataccaccctctac
agaacctcgtatcaaggaataatgatgctgagatacactgtattttttttaaagccctgc
gaagtctgttgaagactatacatgtcttcctttctatgaatagagacattatcctgtagt
cagtataggaaactggttttcttttagcattgacacaatgtgaatcttgactaattgtga
cttttttttttttttttttttttttaagacggagtctggctctgtcacccaggctggagt
gcagtggtgcgatctcggctcactgcaagctctgcctcccaggttcacgccattctcctg
cctcagcttcctgagtagctgggactacaggcgcccaccaccaggcctggctaatttttt
gtattttttagtagagacggggtttcggcgtgttagccaggatggtctcgatctcctgac
ctcgtgatctgcccgccttggcctcccaaagtgctgggat
>IGR1155a
tcactgcaagctctgcctcccaggttcacgccattctcctgcctcagcttcctgagtagc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-222
tgggactacaggcgcccaccaccaggcctggctaattttttgtattttttagtagagacg
gggtttcggcgtgttagccaggatggtctcgatctcctgacctcgtgatctgcccgcctt
ggcctcccaaagtgctgggattacaggcgtgagccaccacgcctggctgtttttgtttct
gtttgtttgtttgtttgtttgagacggagtttcactcttgtcacccaggctgaagtgcaa
tggtgtgatctcggctcactgcaatctctgcctcccaggttcaagcgattctcctgcctc
agcctcctgagtacctgggattacaggcgcgtgtcaccacacctggctaatttttctatt
ttcagtagagatggggttttaccatattggccaggctagtcttgaactcctgacctcagg
tgatccgtctgccttggcctcccaaagtgctgggattacaggcatgagtcactgcgcctg
gcctcctctctttatttgactactagaatcttcagcaagcatatcagacttcatgcatac
tttttatacacttctctcctggtttcattactttcttgcccttatttctacactgccttg
ttttcccattaatttgaaatacatttatctttgctctatt
>IGR1156a
tcccaaagtgctgggattacaggcatgagtcactgcgcctggcctcctctctttatttga
ctactagaatcttcagcaagcatatcagacttcatgcatactttttatacacttctctcc
tggtttcattactttcttgcccttatttctacactgccttgttttcccattaatttgaaa
tacatttatctttgctctattgtatataactaagtaaataatttctggaacaaggaaggt
tacaaagtaaactaataccatcagatccactaagtttagaccatcactttaaaaggggtc
atagatcattaatcttaacaatttcgtatatatatacagagagctgctgcgaatttacag
attgtgatttttatataggcaactacataaaagctagtgataattattttgttatatatg
catcataaatttatacagttattcaatatgtattaggccaggcagagatttgatctccct
ttgactgatatttcatatatttgaaattcttggtggtacagaaagagacccagcagaaaa
ctaatgtaactaatcttccaaatgattttaagcaaccacttataaccaagtggttaaggc
attcaaatagtaaattttgtttaaaacagtaagaacagagaaatggtatagtttttaaag
gcattaactaccatgcttgcataaagcatgtgatgatggc
>IGR1157a
tttgaaattcttggtggtacagaaagagacccagcagaaaactaatgtaactaatcttcc
aaatgattttaagcaaccacttataaccaagtggttaaggcattcaaatagtaaattttg
tttaaaacagtaagaacagagaaatggtatagtttttaaaggcattaactaccatgcttg
cataaagcatgtgatgatggcttcttaatatgattttgattatactatagaaattaattt
ctttaatagagaaaataaatgatataggaatcaactggaaaatgacttaatatataaata
ttttccttacagattactttcaagattattaaaccttaatccgtcttttgtgaatttatg
ctacataaagatatgttagaataagaaaagatacagatacatgttaaagatgttcattgt
cacacagtttgtgataaggaaatgaaatcaatctgagtaagtgctggtatatacacaaaa
tggactattttataatcattaaaaagaatgtgatacatctgtgagttgataggtaaaatc
aaattatgttaagtgaaaaaaggtacagaataacatgatacgaccccatccataaaagta
aatttaaatatatatatatatatatacacacacacctaaatttatctacctatctgctgg
tatatgaataaaaaacttctttaagaacaaataagtgtaa
>IGR1158a
taaaaagaatgtgatacatctgtgagttgataggtaaaatcaaattatgttaagtgaaaa
aaggtacagaataacatgatacgaccccatccataaaagtaaatttaaatatatatatat
atatatacacacacacctaaatttatctacctatctgctggtatatgaataaaaaacttc
tttaagaacaaataagtgtaacagttaatgacatgtagaagtaagattgagaattaggag
aaggggaggaacacttttatgcctttatgttcgaacttttaccatgagtcttttactgaa
aataaaaataaaaaataaatgaagtaagaatgttattggaattatttttctttacttttt
gcatttctttttagagacagagtctcgctgtgtcgcccaggctagagtgcagtggtacaa
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-223
tcacagctcactgcaacctctgcctcccaggttcaggtgattctcatgcctcagcttccc
gagtagctgggactacaggtgcgcgccgccacggccagctaatttttgtattttcagtac
agacagggtttcactgtgttggccaggctggtcttgatctcctggcctcaagtgatccac
ccgcctcggccttccaaagtgcagggattacaggtgtgagccaccacgcttggcctcttt
cctttttgcatttctattcaatggatcttctattgaaaat
>IGR1159a
tgcgcgccgccacggccagctaatttttgtattttcagtacagacagggtttcactgtgt
tggccaggctggtcttgatctcctggcctcaagtgatccacccgcctcggccttccaaag
tgcagggattacaggtgtgagccaccacgcttggcctctttcctttttgcatttctattc
aatggatcttctattgaaaataaaactatagaaaagaatgtcataggtgtaagtgatatc
ataagcaaaacagacctaccttctgtgtatcaatatcttgtctcatgagtctcatatctt
catttatcttttctttgtgtttctcgcattcacttagttgagctattactttattaagtt
cagtttctttttgctacaaaaaagaaaattctttaagcacatgaataaaaatacaatcaa
ataaataattttaagttttaaattaccttcttatagtcgtctttcccatcttgaatataa
ttctcaatgtctttcatatagccatgaatatttttaaccttctctttaatatcattcagc
tgtagaaaaatattcattaaatttacactggttgtacttaagggcacataacaggagagc
acagtaaaacactggctgggaagttatgaacattgggttccagtttccaccactactgaa
ttttatgatcgcagacaagtccctttctcacctataggaa
>IGR1160a
agccatgaatatttttaaccttctctttaatatcattcagctgtagaaaaatattcatta
aatttacactggttgtacttaagggcacataacaggagagcacagtaaaacactggctgg
gaagttatgaacattgggttccagtttccaccactactgaattttatgatcgcagacaag
tccctttctcacctataggaattgattaattagtctcatttcttaacttctattgtagat
caagcagcaaaataatttacatcaaatccttgttctaacaagaatttctaatgtcaaaat
tataccatgaatctgaaaatactatttatcttatgctatttaatttcatgtgaaataagt
gtccgacgtggtgctatgaacataagtttaatacagatatttgataagtaaatatataaa
tgaaatcttactttatcctgtgctattttgttgcttgtattttttttgttgattaattct
tctttttcttgctggaacttttccaatgttgtttccaaagggcttacctgctctttagca
tcctaaaaatataaaaaagataaagtattatataatattccattatcttactttaggggt
cagacttcacagtcttaataaaagcactttctatgtgccaggctctaaaagtcaactcat
ttgctcctttcaatgaccctatgaggacagtaccatcatt
>IGR1161a
tttccaatgttgtttccaaagggcttacctgctctttagcatcctaaaaatataaaaaag
ataaagtattatataatattccattatcttactttaggggtcagacttcacagtcttaat
aaaagcactttctatgtgccaggctctaaaagtcaactcatttgctcctttcaatgaccc
tatgaggacagtaccatcattttcagtcctatatttcaaacgagcaaacagacacagaga
atgatttgtccagggtcacaacagccagtaaatgaagcagccaagattttaacccagtcc
agctccagagttcacgctcttaaccactacgcatgctatactgcatcaaccactaatttg
attcttaatctaggccatgtgctcccaattatattagcgtgtggcttcaagcatgagttt
tcatgattttataggtgcccgtcactgctgcatgatcaaagaataggaaagctcattcag
tccagacttttctttttcagatgaaaacatgatggtaaaaacacttctgtccttaagctt
agcctgctaaggctacgcagatatttcatggtaataaaagcatactgttaaactaatgtt
ggtgtctccacaactattttggaaggaacggggctttcaagtaataaactattttactaa
atagaagtccccattatttagccttgtaacactaaatcta
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-224
>IGR1162a
gatgaaaacatgatggtaaaaacacttctgtccttaagcttagcctgctaaggctacgca
gatatttcatggtaataaaagcatactgttaaactaatgttggtgtctccacaactattt
tggaaggaacggggctttcaagtaataaactattttactaaatagaagtccccattattt
agccttgtaacactaaatctacaacgtagttatatgataaccacagttcaaaacagaggt
cctcaagcactttaagattctgaagtactgagtgaatctatagaggtagatacaattatt
tagtaattacttcaatataggtctattttatcatactgggaagtggtatggtgtgttagg
aagtcaaatgccctcagtgtcaaaagatctatcagaaaatcaactctgcttcctattagc
tgcataaacttaggcactcatgagacatttgtaaatctcaatttttctataaagagattt
catcatctaaatagggttgctgaggcactgaatggttcaatgtcaaagtgctttataaat
agtaaaaaattatacagatgcaagtactattttatattatattctgaacctctgatattt
tgtaatctaaaatttaataaaaatttatagtaattattcagtaatatacttagtgcttat
tgaatgagtacgcataattatataaacctaggtaagattg
>IGR1163a
ctgaggcactgaatggttcaatgtcaaagtgctttataaatagtaaaaaattatacagat
gcaagtactattttatattatattctgaacctctgatattttgtaatctaaaatttaata
aaaatttatagtaattattcagtaatatacttagtgcttattgaatgagtacgcataatt
atataaacctaggtaagattgtttataactgtttataactggttgagtcttagatgtgat
taatctatataagggatgtcaaatgcattccagtggcaactgagtgcctgctcactgtat
tggtaagggttctgaaaccacatccggaatcaaatggaaagagtgctatgactgagagtg
accgccatagataaaggatctgcagataagacaaacctcctgtacaagcaggaatcctta
tacagaattaaccaaccaccacctgaccacctccaataacatttactacttaaccaggca
gccagttcttccttattatggcaaactccttcttccagaaatctttacttactagtacaa
gttctatcacttaggaaccacacaaataattattataccattttcatttgatcctcataa
tagctggttttcaaagggaatgcttccagtttttgcccattcagtatgatattggctgtg
ggtctgtcataaatagctcgtattattttgaaatacattc
>IGR1164a
ggcaaactccttcttccagaaatctttacttactagtacaagttctatcacttaggaacc
acacaaataattattataccattttcatttgatcctcataatagctggttttcaaaggga
atgcttccagtttttgcccattcagtatgatattggctgtgggtctgtcataaatagctc
gtattattttgaaatacattccatcgatacctagtttattgagagcttttagcatgaagc
ggtgttgaattttatcgaaggccttttctccatctattgggataatcatgtggtttttgt
ctttggttctgttcatgtgatggattacatttattgatttgcatatgttgaaccagcctt
gcatcccaggaataaagccgacttgatcgtggtggataagctttttgacgtgctgctgga
ttcggtttgccagtattttattgaggatttttgcatcgatgttcatcagggatattggcc
tgaaattttctttttttgttgtgtctctgctaggttttggtatcaggatgatgctggcct
tataaaatgagttagggaggattccctctttttctattgttaggaatagtttcagaagga
atggtaccagctcctctttgtacctctggtagaattcggctgtgaatctgtctggtcctg
gacttcttttggttggcaggctattaattactgcctcaat
>IGR1165a
tgtgtctctgctaggttttggtatcaggatgatgctggccttataaaatgagttagggag
gattccctctttttctattgttaggaatagtttcagaaggaatggtaccagctcctcttt
gtacctctggtagaattcggctgtgaatctgtctggtcctggacttcttttggttggcag
gctattaattactgcctcaatttcagaacttgttgttggtccatttggggatttgacttc
ttcctggattagacttgggagggtgtatgtatccacgaatttatccatttattattttct
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-225
agtttatttgcgtagaggtgtttatagtattctctgatggtagtttgtatttctgtggga
tgggtggtgatatcccctttatcattttttattgcatctatttgattcttctctcttttc
ttctgtattagtcttgctagtggtctattttgttgatctttttaaaaaaccagttcctgg
attcattgatttttttgaagggtttttcgtgtatctccttcagttctgctctaatcttag
ttatttcttgtcttctgctggcttttgaatttgtttgctcttgtttctctagttctttta
attttgatgttaaggtgttgaattcagttatttcctgctttctcttgtgggcatttagtg
ctataaatttccctctacacagtgctttaaatgtgtctca
>IGR 1166a
gggtttttcgtgtatctccttcagttctgctctaatcttagttatttcttgtcttctgct
ggcttttgaatttgtttgctcttgtttctctagttcttttaattttgatgttaaggtgtt
gaattcagttatttcctgctttctcttgtgggcatttagtgctataaatttccctctaca
cagtgctttaaatgtgtctcagagattctggtacattgtatctttgttctcactggtttc
aaagaacatctttatttctgccttcatttcgttatttaaccggtagtcattcgggagcag
gttgttcagtttccttgtagttgtgcggttttgagtgagtttcttaatcctgagttctaa
tttgattgcactgtggtctgagagactgtttgttatgatttctgttcttttgcatttgct
gagagtgttttacttccaattatgtggtcaattttagaataagtgcgatgaggtgctgag
agttctggccattacactaataaagagcatttcatattaaagaaacatgggctgggtgag
gtgatgtaagcctgtaattttgggaggccaaggctgcattgcttgaggccatgagtttga
gaccagcctgaacaacatagtgagaccctgtctctagaaaaattttaaaaattagccagg
cgtggtggtgtgtgcctgtagtcccatctacttgagaggc
>IGRI 167a
ataaagagcatttcatattaaagaaacatgggctgggtgaggtgatgtaagcctgtaatt
ttgggaggccaaggctgcattgcttgaggccatgagtttgagaccagcctgaacaacata
gtgagaccctgtctctagaaaaattttaaaaattagccaggcgtggtggtgtgtgcctgt
agtcccatctacttgagaggctgaggcaggaggattgcttgagctcaggaggtcgaggct
gcagtgagtgagctgtgactgtaccactgcattccagcttggaagactgatgaagactct
gtctctaaaagagaagaatggggcggggcatgctggctcacgcctgtaatcccagcactt
tgggaggccaaggtaggcggatcaccttagttcaggagtttgaaaccagcttgtccaatg
gcgaaaacccgtctctactaaaagaacaaaaattagccaggcatggtggtgcacgcctgt
aatcccagctactccagaggctgaggcaagagaatcacttgaacccaggagatggaggtt
gcagtgagccgagatcgtgctactgcactccagcctgggtgacagaacgagactgtctca
aaaaataaaaataaaaataaataattaaaataattttacaaaaaacatgtatggatattc
ttacctttatctctctgtacaaagactgaacttcagtgga
>IGR1168a
gctgaggcaagagaatcacttgaacccaggagatggaggttgcagtgagccgagatcgtg
ctactgcactccagcctgggtgacagaacgagactgtctcaaaaaataaaaataaaaata
aataattaaaataattttacaaaaaacatgtatggatattcttacctttatctctctgta
caaagactgaacttcagtggataattccacagtctgctcctccagttgctgacgacgttg
caaattagtggatatctgaagtttctcagattttagctcatttgttgtactttttagatg
ttgaatctgttcctgctggtcctgtataagcttacgattcaattcaatcttactagaaac
tacacaaaaacatattatcacagtaattaatgtaagggcatagaaaatactatttgtatc
attcttcccatttttatcggtctatggaatccacaaatgctatttctgtgggccccaccc
actgcaacaaaaatacaatgagaaccctgctagttctcaaatcagcttgatgttccctgc
tggccactcacagggaaagcttacagggcaggtatgaatgagaaagaatacagctcatgg
ccaggcgcactggctcacacttgtaatcccagcactttgggagactgaggcaggtggatc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-226
acctgaggtcaggagttcgagatcagcctgacaaacacag
>IGR1169a
gagaaccctgctagttctcaaatcagcttgatgttccctgctggccactcacagggaaag
cttacagggcaggtatgaatgagaaagaatacagctcatggccaggcgcactggctcaca
cttgtaatcccagcactttgggagactgaggcaggtggatcacctgaggtcaggagttcg
agatcagcctgacaaacacagtgaaaccccatctctacgaaaaaatacaaaaattagctg
ggcatagtgatgtgtgcctgtaaccccagctactcaggagggtgaggcaggagaatcact
tgaacccgggaggcggaggttgcagtgagccaagattgcaccattgcactccagcctggg
cgacaaaagtgaaactctatcttaaaaaaaaaaaaaaggaaaagagaatacagcttattt
catactctcctactgttcaaaatctgttgtgcaaagtaagagaacaaagagaagtgatgc
ttttcagaaaaaaagagcaaatatatgtggacaggaaggaacttcgttgtccatgtaaca
gatataaaattgactgtaaaaggcatgtgctcgcaatgtcaaagtctctatgagtacaga
aggacacagactgtattacctgtgtctaacttgtgctgtttctcttgtttctcctggttg
acttgttggacagttcgatctaagtctattccttgtagct
>IGR1170a
aatatatgtggacaggaaggaacttcgttgtccatgtaacagatataaaattgactgtaa
aaggcatgtgctcgcaatgtcaaagtctctatgagtacagaaggacacagactgtattac
ctgtgtctaacttgtgctgtttctcttgtttctcctggttgacttgttggacagttcgat
ctaagtctattccttgtagcttagctgcttgttgtgcaatttttctttcaacatctttaa
gttccatcttaagaatataacaaaatgatttcctttaataaacttactgcattattcaaa
atctttaaaaattaattgctcttatcatttattttttaaatctaaacttataaaccattt
ctagatacaattttagcaaagtttaataggataaaagtgaaattaattatcagcaattca
aatgatgtaaacaaaaggaagctgactaaagatgaaaaacaaacagaactgtcttaattt
ttaaatttatgaattaaaaagtttaaacccagggatgtaaactaagcagtttctccctga
gggtatctgaaattcaggatggggaattctaaacacaacctgtacctgaatactagctac
tatttttaactctcacacttcaaattcaagccaccatggaacaagttttattctgcctta
aactacaataaacttacctggaacctctccataattgtaa
>IGR1171a
agtttaaacccagggatgtaaactaagcagtttctccctgagggtatctgaaattcagga
tggggaattctaaacacaacctgtacctgaatactagctactatttttaactctcacact
tcaaattcaagccaccatggaacaagttttattctgccttaaactacaataaacttacct
ggaacctctccataattgtaacatctgtcaggcatactttggcactttcttcttcaggca
ttattgtacccaagagtgtttcttgttcttctatgtcgttctttaggcgctgtatgtctc
tattgacattctgcagtttgtttcttaattctggtatttccttctccttcaaatcaatta
tgctttgcctaaatagaaaacacaattaaaaataaagtatctgatgtttctcacagttag
actgaggttatgtatttttaggaagaataccacagaagtgacattgtgttcttttcaggg
tatcatatcagtggatatggaatcatgatatcaatatgtcttattactgatgatgttaat
ccttattcacttggcttagatggtgttggccaggtttctccactgtaaagttactgtttt
agtctttgtaattaacaagtatcttaggagagaaatgttgagactatgtaaatatcttgc
ttctcaactttctgcctactgattttagtatccactgaca
>IGR1172a
gaatcatgatatcaatatgtcttattactgatgatgttaatccttattcacttggcttag
atggtgttggccaggtttctccactgtaaagttactgttttagtctttgtaattaacaag
tatcttaggagagaaatgttgagactatgtaaatatcttgcttctcaactttctgcctac
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-227
tgattttagtatccactgacagatcttgcttgcaataattattactgtggtgtttgtcaa
actgagaaatattctactaatgaactggtcatattgaccaaaagtgttaaggtcatgaaa
gataaagacagattgttacagactgcaggagcctaaggagaaataacaactagatgctac
gtgggatcctgcatggaaccctgaaacagaaaaggcattgatggaaaaactgctaaattc
gatatggtctgtaatttagttagtagcattatatcaatgttaatcctggttttgataact
gtattataacagagtacataaattgttaacatcaggaggagctggatgagggatatatat
gaataatttgtattatttttataatttttctgtaatcctaacattatttcaaaataaaaa
ttttttaaattacaggaaaaaaaggaaggaagccagccactaagtgaaatgctacatggg
tttaaggtacaaaatgtcaacccattttactggtactcac
>IGR 1173 a
aaattgttaacatcaggaggagctggatgagggatatatatgaataatttgtattatttt
tataatttttctgtaatcctaacattatttcaaaataaaaattttttaaattacaggaaa
aaaaggaaggaagccagccactaagtgaaatgctacatgggtttaaggtacaaaatgtca
acccattttactggtactcactactgtagctaatgaattaccacctccatggcaggtact
gacaactatttttgctgatgcctctgaaacaataatatgtatttaatcttttaaaaaaaa
tttacttcagaaatattccaaattcttatttaaaattatattgaattagtatgacaaagc
agtagaataaattaaactggtctctaataggagtcttattataaacttaaagaataacca
gaaactcaagtggctattacttaatgattttttaaaaatgcaaactatgaccaagaaatg
ccaacctgacctgtggcaacagacctatagttttttaaaattttttaattatttatttat
ttttatgctttaagttctgggatacacgtgcagaacgtgtgggtttgttacataggtata
cacgtgccatggtggtttgctgcacccatgaacccatcatctacattaggtatttctcct
aatgctatccctcccctagccccccaccagcagacaggcc
>IGR1174a
cagacctatagttttttaaaattttttaattatttatttatttttatgctttaagttctg
ggatacacgtgcagaacgtgtgggtttgttacataggtatacacgtgccatggtggtttg
ctgcacccatgaacccatcatctacattaggtatttctcctaatgctatccctcccctag
ccccccaccagcagacaggccccagtgtgtgtgatgttcccctccctgtgtccatgtgct
ctcattgttcaactcccatttatgagtgagaacatgcaatgtttggttttctgctcctgt
gttagtttgctgagaatgatggtttccagcttcatccatgtccctgcaagggacatgaac
tcatccttttatatggctgcatagttactccatggtgtatatgtgccacattttctttat
ctagtctatcattgatggtcatttgggttggttccaagtctttgctatcgtgaacagtgc
cgcaataaacatatgtgtgcatgtcagacctacagtttttttttataccacagaaatagg
aggtatttgtattccacataataaatatgaaggtatgcaggttatgagtaattccatgcc
aatgtttcctcttgaacactgttgtcacagattagtagttggccttaaattatgtgccca
atatctaaaaagtgacacagctatgacagcctaataatga
>IGR 1175 a
catgtcagacctacagtttttttttataccacagaaataggaggtatttgtattccacat
aataaatatgaaggtatgcaggttatgagtaattccatgccaatgtttcctcttgaacac
tgttgtcacagattagtagttggccttaaattatgtgcccaatatctaaaaagtgacaca
gctatgacagcctaataatgatggccaagcatttattaaactggggacatctctgtgaag
aactgtaggtatacatacaattttaaccctatttttacattttcctacacacacacaaaa
tctttcatcaatatggtctaggttttggtgccttcttttttgatgattacataagatgtt
aaaagaagttttctggccgggtgtgacggctcacgcctgtaatatgagcactttgggagg
ctgaggctggtgaatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaa
accccatctctactaaaaatacaaaaaatcagttgggcgtggtgaagggcgcctgtaatc
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-228-
ccagctacttgggaagctgaggcaagagaactgcttaaacccgggaggtggaggttgcag
tgagctgagattgtgccactgcactctctgggtttgtttttcttttttttaaatttatga
cattttattttttattttcaagagttaatttttctcacga
>IGR1176a
tacaaaaaatcagttgggcgtggtgaagggcgcctgtaatcccagctacttgggaagctg
aggcaagagaactgcttaaacccgggaggtggaggttgcagtgagctgagattgtgccac
tgcactctctgggtttgtttttcttttttttaaatttatgacattttattttttattttc
aagagttaatttttctcacgattcacaaggttttttaaaattattttcaatagataaatc
ataattgcaaacatttatggggtacaatgtgatgttctgatatatgtacacaatgcacaa
tgattaaataaaggtaatttaacatatccattaccttgcctgcctatcattttttataga
cagacatttgaaatttactctttggatttctgttttttcagaaactcaattcacctattt
ttagacaacattccttttctaaggggattgtgtgtaaaaaggctcacacagatatggtac
tgaaaaaaacctgtgggagaaataccaattgagtttgcatttaaatgaggtgctataata
aatgaatctgagtcagtactagacaaaatgataaacaggtacattttcagctgagatctc
agtcatgatgttaggtttatattagatactggcgaatttgaggctttaaatgaaaatatt
tcccgcaaagaagataagcaagatatggctccccactacc
>IGR1177a
aaataccaattgagtttgcatttaaatgaggtgctataataaatgaatctgagtcagtac
tagacaaaatgataaacaggtacattttcagctgagatctcagtcatgatgttaggttta
tattagatactggcgaatttgaggctttaaatgaaaatatttcccgcaaagaagataagc
aagatatggctccccactacctctctgagctcatcttccacaacttttccctttggcctt
caggtcaaatatgtctcagagattttgcactgcctagaatattcttcttatggacaactg
catggctgactccctcacttctctcaagtttccactccactgccaccttcatcaagtccc
ctcctaccacccttcagctagtccctattcccttatcttgctgtagttttctcaatgccc
ctgatcatcccctggcatattatatatttacttatttgtcatccatctcctccccactgg
gatataaactccatgagggcagggactttgtccattttgtttactgctgtattacctgca
ctccagtagactgcctatattggttgcatgaatagacagttctcatgatagtggtggcat
caagggcatattctaaaggtgaaaaagcaaatggtgcacagataaatttaatcttgttac
tttacccctcttcaccaataaccttccacctaagtgacta
>IGR1178a
cagggactttgtccattttgtttactgctgtattacctgcactccagtagactgcctata
ttggttgcatgaatagacagttctcatgatagtggtggcatcaagggcatattctaaagg
tgaaaaagcaaatggtgcacagataaatttaatcttgttactttacccctcttcaccaat
aaccttccacctaagtgactatcataaatagacctccacaatgtctctgaaagtgacccc
acgggatatttgaaagtagtatcctaaccagaggtggaaggaagcttaatgatcatgtaa
atcaatcccctcactttacgtgggggatacgaaggcccaaatgggttaagtaacatccct
aaggtcacccagcagagttggaatttgaagtcaacctgactgcactcttaggcaattgct
ttcccatatttaaaaaaaaaaaaagtcctcttggttgggcatggtggcttatgcctgtaa
tcctagcactttgggaggctgaggtaggaggattgcttgagcttaggagttcgaggcttc
gatgagctataatcaatcacaccactacactccagcctgggtgacaggagcaagacccta
tctatcaatcaatcaagtcctcttaattcattattgacctttcatttgtggatttattta
aacttaaaaaaagtgttttataatgttatttcctactatt
>IGR1179a
tgaggtaggaggattgcttgagcttaggagttcgaggcttcgatgagctataatcaatca
CA 02394033 2002-06-10
WO 01/42511 PCT/US00/33632
-229
caccactacactccagcctgggtgacaggagcaagaccctatctatcaatcaatcaagtc
ctcttaattcattattgacctttcatttgtggatttatttaaacttaaaaaaagtgtttt
ataatgttatttcctactattgggaagaagacttcctctctcatttgtcccaaactcatc
cttctccagttttccagaatggcccactgacattctgttagagcttgctaaacaaacagg
ggttcatcatttccctgctcttcgggtcttcaagttttggtttctttataaaaatggttt
cctcacacatgtgtcctcacttagcagccctgccagcatcttggtccattttcagtgctt
cctgtaggccttttctagcttcaggttctcttaaaatgtgtggtaaccagccatttacct
ggctaacctagctgagcccagtcatcccatgaaaccatgaaaaactaatcactgcgagac
agttttgagggggtttgttacaagcaatcaataacgggaatagacactacagttctcatt
cattcagcaaatagttatcaaagttacaatatagaatatacaaatgtgtggttgcctagt
ctctaggtaaccagaatggcacacagatgctactgcagat
>IGR1180a
agtcatcccatgaaaccatgaaaaactaatcactgcgagacagttttgagggggtttgtt
acaagcaatcaataacgggaatagacactacagttctcattcattcagcaaatagttatc
aaagttacaatatagaatatacaaatgtgtggttgcctagtctctaggtaaccagaatgg
cacacagatgctactgcagatatagggttaggcagattcaagtcagccacaagtacttcg
acactcttcccatcaagagatacagtatcctccctcactgaatcttgggagtttctgtga
ccactctaaccaacagaaaaagaagtgtcaccatgccagtttcttggtctaggccttaaa
ggacttgcagcttctacttcctgttcatggaatacttacccttaggatactctgtttagt
aacccagtcactgtgctgccaaaagcccaagacgcatgcagaggccatgtgaagatgtcc
tattttgacagccccagctgagctcccagacaatagtgagcatcactgtcagtcatgtga
gccatcaagaacatccagctcggttatgctttgagacgactgcagccaacatctgactgc
aaccgtaagaccccaagtgaaagccacctagctgagcccagtcataccacagaaccatga
aaaattattgtgagacagatttgaggtttgttacatagca
>IGR1181a
gagctcccagacaatagtgagcatcactgtcagtcatgtgagccatcaagaacatccagc
tcggttatgctttgagacgactgcagccaacatctgactgcaaccgtaagaccccaagtg
aaagccacctagctgagcccagtcataccacagaaccatgaaaaattattgtgagacaga
tttgaggtttgttacatagcaataaataattggaacagacattacagttctcattcattt
agcaaatagttatcaaagttgcaatatacaaggaactgtggagatacaacgagtaagaca
tgcaccttactcttagaggggaaactgtggcccagcacggtggctcacgcctgtaatccc
agcactttgggaggctgaggcaggcgattgcctgaggtgaggagtttgaaaccagtctgg
ccaacatggtgaaaccctctctctactaaaaatacaaaaaaaattagccgagcctggtga
cgtgcgcctgtaatcccagctacttgggaggctgaggcaggggaattgcttgaaccgggg
aggtggagattgcagtgagccaagactgcgccactgtactccagcctgggcgacaaagca
aaactctgtctcaaaaaaaaaaaaaaggagccgtgatagctagggtcctaaaatataata
cgatgttaatttctgccatttattgtataacagtctaaca
>IGR1182a
ctacttgggaggctgaggcaggggaattgcttgaaccggggaggtggagattgcagtgag
ccaagactgcgccactgtactccagcctgggcgacaaagcaaaactctgtctcaaaaaaa
aaaaaaaggagccgtgatagctagggtcctaaaatataatacgatgttaatttctgccat
ttattgtataacagtctaacacagaactaagctcatatttctactacgtgtactttctac
caatttcaaattttatccatttgatctttttcttttcaagatactaccttattcctctcc
ttcctttttattctcaaactactgcctctgtctcctcatctctgtggccccaataatctg
gttttcacccttgatgcttgtgttggttatctattgttgcataacaaagtatcccaaaac
CA 02394033 2002-06-10
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-230
ttagcagcttaaaataacagcacttattatttctcagagatatgaggatcaagagatacg
cttctgactcagggtctcgcatgaagtcgcaatcaagctgtcagccaggactgcagtcat
cttaaggcttgactgctacaaagtctgcttccaaactcacttgctcaaaggcctcaggtc
cttggcatatgggcctctccagagggctgcttgcaacatggcagctagcttccctcagac
aagagacagagggagacagagtgagtgagagaggggagga
>IGR1183a
catgaagtcgcaatcaagctgtcagccaggactgcagtcatcttaaggcttgactgctac
aaagtctgcttccaaactcacttgctcaaaggcctcaggtccttggcatatgggcctctc
cagagggctgcttgcaacatggcagctagcttccctcagacaagagacagagggagacag
agtgagtgagagaggggaggagtgggggagagtgagcgagttcacacaagggtacaagca
cattgcgagaacagaagaagccatagtaccttaaataacctaatgttggaaaggccatgc
tatcacttctgcctgttttatcagttatatagaccaatcatgcaacagcatgagatggga
ctatacaagagtataaataccaagaggccgagattactagggaccatcttagaagttggc
tgccacaaaccacatcttcttaggcctttctttctccttttcctgaaactcctccttggt
tttccaggacaatcactttcactctcctggtttttctgcttcctgagcttttctcagcct
gtttcagtcaatatattaatattagattaattttcctaaaatacatctttcactaactcc
cttaggttggctcctcatcacctatcagagttacaactagacctgaatataatgtagccc
tatctccccaacatacaggactcaatccctataaataatt
>IGRI 184a
cactctcctggtttttctgcttcctgagcttttctcagcctgtttcagtcaatatattaa
tattagattaattttcctaaaatacatctttcactaactcccttaggttggctcctcatc
acctatcagagttacaactagacctgaatataatgtagccctatctccccaacatacagg
actcaatccctataaataattccccaaactccagataacatttctactgcagcataggtc
atactcctcttccctttgcaccgtgttctgacttccgtctcctctcagttgagctgaatg
aacttctccaggtcttatattcctcttcctgcctcattctcaaaatattcttctcattct
gtatccattggctcctcccttcttacctaacacatctgtttgaatcattttttaagcact
ttattaagcctagctttctaaatgttgaattctgagagcttgtcttcttaatcagaccat
tagctcctggagggtcatgtcttaggtctctggcactagccttgttctctatgttctggg
agacactaaggcaatcatcacatatttcctgacttgatttttgtttgtaaacagaacata
acacgaatttcttgtataagtgatggaaaatataaacaaccgaaaatcatctatgattca
ttcttttagcaagtggaaaagacattaaaaacatagttta
>IGR1185a
tcttaggtctctggcactagccttgttctctatgttctgggagacactaaggcaatcatc
acatatttcctgacttgatttttgtttgtaaacagaacataacacgaatttcttgtataa
gtgatggaaaatataaacaaccgaaaatcatctatgattcattcttttagcaagtggaaa
agacattaaaaacatagtttaaaatctgtcttctgggagaacttttcaatacttaaattc
ttttgctgggttcagaaagtggcatgtcaacagacagtcctaaatctgtgaaaatctatg
cccacaagctaagtcttgggaattaaacacacatacaaaagaacgtaaagactgtgtcta
cctcatagtttaagaaataagcttactggctatgcacggtgctcacacctgtgatcccag
cactttgggaggccgaggtgggccaatcactttgaggccaggagctcgagattagcctgg
ccaacatggtgaaactccatctctactaaaaattacaaaaattagctgggcgtggtggta
catgcctgtaatcccagctactgaagaggctgaggcatgggaatcgcttctgggaggtgg
aggttgcaatgagccaagatcatgccactgcactccagcttaggtgacagagagagactc
tgtctcagaaaaaaaaaagaaaaagaaaaaaagacaggaa
CA 02394033 2002-06-10
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-231-
>IGR1186a
tctctactaaaaattacaaaaattagctgggcgtggtggtacatgcctgtaatcccagct
actgaagaggctgaggcatgggaatcgcttctgggaggtggaggttgcaatgagccaaga
tcatgccactgcactccagcttaggtgacagagagagactctgtctcagaaaaaaaaaag
aaaaagaaaaaaagacaggaaacaagcttatctttaaacaaaataattgaatcttcttat
catagaagtgatataagacagggcataccagctcagagtccttactgagtaactaccatc
tgcccaggcatgagatgggtaccttttacaatgtgctgctacatgtacagtgaaggtaaa
tcccattcttacctcatgggcacaagtcccagcatttcatcacgccgcttttcctttttt
tttagctctgattctgttgacttgagtttatctggagcaagtcgcagtttagactgcaaa
tcactgatgacttcttgtaactcagcctctgtctgaaaaactctctgacaaacggggcaa
catgactggttttcgtctgttagctgagtaatgaactgggagtaaactgctgtggctcca
gccagcatggctattttaagaaaataaattatatcaccaatgagaaaaaaacataaaata
cagtattctgaatacggttgtatctttttctataaatata
>IGR1187a
actcagcctctgtctgaaaaactctctgacaaacggggcaacatgactggttttcgtctg
ttagctgagtaatgaactgggagtaaactgctgtggctccagccagcatggctattttaa
gaaaataaattatatcaccaatgagaaaaaaacataaaatacagtattctgaatacggtt
gtatctttttctataaatatatgattattcttgctttataaatatattataaaagaaata
aaaattctgatatttaaaattccgatattcgcttccaaagagcatgatacattcagattt
gtataaatattttttggtaacacattataagtataacaaaatgcctactgagagctttct
atgtgccaggcactgttctaagggctttataattacaatctcattcacacctcagtacca
caggtggtagttgtgtcctcattttatagacaatgaaacacaggaaggtttcagtaactt
gcctaaagtcacacagtgagtaagttgtagagccaggactgaaatccaagccattaggct
ccataaccaggtttttaaattccccatccttaacagttacctgtgaatgaaaattcaaag
gtgtcaaagtatcctgataatataaagtagacaacttacctcgctgttttgatgattttt
caatttcctctttaagcctgtctaaatcactttcaaaatc
>IGR1188a
gtaagttgtagagccaggactgaaatccaagccattaggctccataaccaggtttttaaa
ttccccatccttaacagttacctgtgaatgaaaattcaaaggtgtcaaagtatcctgata
atataaagtagacaacttacctcgctgttttgatgatttttcaatttcctctttaagcct
gtctaaatcactttcaaaatcctggctaccacaaacatcaaacagcttgtcttcgtaact
ggacaactgctcttcctttctttttagttcattatttatatgatttttattctgctcaga
tgaagctagttccttgctaaaataagagcaaatatggattttcattttaaaataggagaa
attagtttgaaaatttgagtaggcaaaaacaagacaaattctgccaacaaatcatgacaa
gagtttggtatgaccaaataatttttttcagaagttgagggactagtccacttctgcctt
aactctccccctaggacactgactcacctgccagtcctactcatgggcctgctcccagaa
aaatgtacacagaattctgcctggtttctgggggttcatggtctttgatcccaggttaag
cctcagcaagatgcttgctaggactattggacagaaagaagacaagagaacatccccgta
attccctttagtcctttcacaaatactacttccttactct
>IGR1189a
tgactcacctgccagtcctactcatgggcctgctcccagaaaaatgtacacagaattctg
cctggtttctgggggttcatggtctttgatcccaggttaagcctcagcaagatgcttgct
aggactattggacagaaagaagacaagagaacatccccgtaattccctttagtcctttca
caaatactacttccttactctcctgtaaatactgtttcttttgtatcctccccctccttg
ttgctgtcatccacttgcgtccagatcagtcattccctctcattcatcaaagattttgct
CA 02394033 2002-06-10
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-232-
tactagtacaatttatccccactttaattcttaaacatcatcctagccaacctcaatact
cacacataacatggtttttcaatttgcaggtttagatgcattagctaccatgtaatcaat
ttaatgtattcagcatattttttaaaaatgaaacagaatagacggtaatatattggagta
ggctgtatgtatatgtactactttgagaaatttgtttcagataaatgtgtgtgactgcac
acatgcttcttcatcatgactacccatcctgagtcacagtaaacatttggaaaaaagtaa
ctaatatgatgatattttcattatcctagactcccttgagcacttctcatcaagatcacc
agtgacctaagtgccaagtacagtcttcatcttactctac
>IGR1190a
actttgagaaatttgtttcagataaatgtgtgtgactgcacacatgcttcttcatcatga
ctacccatcctgagtcacagtaaacatttggaaaaaagtaactaatatgatgatattttc
attatcctagactcccttgagcacttctcatcaagatcaccagtgacctaagtgccaagt
acagtcttcatcttactctacctctacgtagcaccaaacactgttgaccttctccttgaa
gactattttcccaaggcacctagacaccacagctatctggctctcaccctggttccctgg
gcacatcccagtttccttcacttgctccttttcctttgcctgctaacattttaaatgttt
gtgcttcccaggaatctaattgtaactccttccctttgcataactctctcaaggtgacat
actaatgactttgagtatcccttacatagcaacaacttccaatctcctgaatttcaaact
ccaatattgtattccctcacagatacttccacaagaaacacagattaaacaccaccaaag
ccaagtccttctactttcctcaaaaatctgtgtggaatttttgacccgcttatccaacca
ctatccaaggtaacatctgagaaacatgatcactttttataatggattactcacagaaat
gaaaatagaatttttaaattttaatcttcataggtctaca
>IGR1191a
cagatacttccacaagaaacacagattaaacaccaccaaagccaagtccttctactttcc
tcaaaaatctgtgtggaatttttgacccgcttatccaaccactatccaaggtaacatctg
agaaacatgatcactttttataatggattactcacagaaatgaaaatagaatttttaaat
tttaatcttcataggtctacaaattttcaagggacaagaggcctaaattactatccgtta
ccattttacttaatttgcaaaatatgaggggtcttcaaaatgttcatggaaaatgtgtat
tataaaaaaaactatgcatgaagttcaaaatgttttgcactgaaacaaactcatactaac
ttgttataacatgtctgaataggatctagtttaaggcactaacaaggttaagacatcagt
ttgaaaagagccccaattaaactgaagcaagaacaagtatcaaatttatggtgaagtgtg
ggtggaagaatggtgaaatcattgatactttacaacaagtttatgagatcaatgccccaa
acaaatcagcagtttacaaatggataactcagtttaagaagggatgagacgatattaaag
atgaagcccacagtgacagactgttcacatcaatttgtgaggaaaaaaaatcatcttctt
catgccctaactgaagaagatcaatgattaacagcagaaa
>IGR1192a
cattgatactttacaacaagtttatgagatcaatgccccaaacaaatcagcagtttacaa
atggataactcagtttaagaagggatgagacgatattaaagatgaagcccacagtgacag
actgttcacatcaatttgtgaggaaaaaaaatcatcttcttcatgccctaactgaagaag
atcaatgattaacagcagaaacaatagccaacaccatagacacctcaattgattcaggtt
acacaattctgactgaaaaattaaagttgagtaaacgttctacttgatggatgcccaaaa
tcactgcttccagatcagctgcagacaacagcagaacttcctcaataagtgggatcaagt
tcctaaagcatttcttcaaagaattgtaacaggaggtgatggaatgtggctttaccagta
caatcctgaagacaaagcacaatgaaagcaatggctaacaagtggtggaagtggtccagt
caaagcaaaagcagaccagataagagcaaaggtcatggcaacagttgttggggatgctca
aggcattttgcttgctgactttctggagggccgaagaaaggtaacaactgcttattatga
gagtgttctgagaaagctagccaaagcattagcagaaaaatgcccaggaaagcttcacca
DEMANDE OU BREVET VOLUMINEUX
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CECI EST LE TOME 1 DE 3
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