Note : Les revendications sont présentées dans la langue officielle dans laquelle elles ont été soumises.
DEMANDE OU BREVET VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.
CECI EST LE TOME 1 DE 2
CONTENANT LES PAGES 1 A 343
NOTE : Pour les tomes additionels, veuillez contacter le Bureau canadien des
brevets
JUMBO APPLICATIONS/PATENTS
THIS SECTION OF TRE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME
THIS IS VOLUME 1 OF 2
CONTAINING PAGES 1 TO 343
NOTE: For additional volumes, please contact the Canadian Patent Office
NOM DU FICHIER / FILE NAME :
NOTE POUR LE TOME / VOLUME NOTE:
CLAIMS
What is claimed is:
1. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 2 mg per day, and the
weight of the companion animal is about 1 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
2. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 3 mg per day, and the
weight of the companion animal is about 1.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
3. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 4 mg per day, and the
weight of the companion animal is about 2 kg;
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Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
4. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 5 mg per day, and the
weight of the companion animal is about 2.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
5. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 6 mg per day, and the
weight of the companion animal is about 3 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
6. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
59
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 7 mg per day, and the
weight of the companion animal is about 3.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
7. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 8 mg per day, and the
weight of the companion animal is about 4 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
8. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 9 mg per day, and the
weight of the companion animal is about 4.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
9. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 10 mg per day, and the
weight of the companion animal is about 5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
10. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 11 mg per day, and the
weight of the companion animal is about 5.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
11. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 12 mg per day, and the
weight of the companion animal is about 6 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
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12. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 13 mg per day, and the
weight of the companion animal is about 6.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
13. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 14 mg per day, and the
weight of the companion animal is about 7 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
14. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 15 mg per day, and the
weight of the companion animal is about 7.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
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Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
15. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 16 mg per day, and the
weight of the companion animal is about 8 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
16. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 17 mg per day, and the
weight of the companion animal is about 8.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
17. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 18 mg per day, and the
weight of the companion animal is about 9 kg;
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Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
18. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 19 mg per day, and the
weight of the companion animal is about 9.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
19. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 20 mg per day, and the
weight of the companion animal is about 10 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
20. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
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Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 21 mg per day, and the
weight of the companion animal is about 10.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
21. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 22 mg per day, and the
weight of the companion animal is about 11 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
22. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 23 mg per day, and the
weight of the companion animal is about 11.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
23. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 24 mg per day, and the
weight of the companion animal is about 12 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
24. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 25 mg per day, and the
weight of the companion animal is about 12.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
25. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 26 mg per day, and the
weight of the companion animal is about 13 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
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Date Recue/Date Received 2021-07-07
26. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 27 mg per day, and the
weight of the companion animal is about 13.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
27. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 28 mg per day, and the
weight of the companion animal is about 14 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
28. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 29 mg per day, and the
weight of the companion animal is about 14.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
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Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
29. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 30 mg per day, and the
weight of the companion animal is about 15 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
30. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 31 mg per day, and the
weight of the companion animal is about 15.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
31. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 32 mg per day, and the
weight of the companion animal is about 16 kg;
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Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
32. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 33 mg per day, and the
weight of the companion animal is about 16.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
33. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 34 mg per day, and the
weight of the companion animal is about 17 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
34. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
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Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 35 mg per day, and the
weight of the companion animal is about 17.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
35. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 36 mg per day, and the
weight of the companion animal is about 18 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
36. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 37 mg per day, and the
weight of the companion animal is about 18.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
37. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 38 mg per day, and the
weight of the companion animal is about 19 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
38. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 39 mg per day, and the
weight of the companion animal is about 19.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
39. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 40 mg per day, and the
weight of the companion animal is about 20 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
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40. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 41 mg per day, and the
weight of the companion animal is about 20.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
41. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 42 mg per day, and the
weight of the companion animal is about 21 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
42. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 43 mg per day, and the
weight of the companion animal is about 21.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
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Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
43. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 44 mg per day, and the
weight of the companion animal is about 22 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
44. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 45 mg per day, and the
weight of the companion animal is about 22.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
45. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 46 mg per day, and the
weight of the companion animal is about 23 kg;
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Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
46. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 47 mg per day, and the
weight of the companion animal is about 23.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
47. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 48 mg per day, and the
weight of the companion animal is about 24 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
48. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
74
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 49 mg per day, and the
weight of the companion animal is about 24.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
49. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 50 mg per day, and the
weight of the companion animal is about 25 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
50. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 51 mg per day, and the
weight of the companion animal is about 25.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
51. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 52 mg per day, and the
weight of the companion animal is about 26 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
52. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 53 mg per day, and the
weight of the companion animal is about 26.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
53. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 54 mg per day, and the
weight of the companion animal is about 27 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
76
Date Recue/Date Received 2021-07-07
54. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 55 mg per day, and the
weight of the companion animal is about 27.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
55. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 56 mg per day, and the
weight of the companion animal is about 28 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
56. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 57 mg per day, and the
weight of the companion animal is about 28.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
77
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
57. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 58 mg per day, and the
weight of the companion animal is about 29 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
58. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 59 mg per day, and the
weight of the companion animal is about 29.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
59. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 60 mg per day, and the
weight of the companion animal is about 30 kg;
78
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
60. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 61 mg per day, and the
weight of the companion animal is about 30.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
61. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 62 mg per day, and the
weight of the companion animal is about 31 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
62. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
79
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 63 mg per day, and the
weight of the companion animal is about 31.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
63. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 64 mg per day, and the
weight of the companion animal is about 32 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
64. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 65 mg per day, and the
weight of the companion animal is about 32.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
65. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 66 mg per day, and the
weight of the companion animal is about 33 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
66. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 67 mg per day, and the
weight of the companion animal is about 33.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
67. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 68 mg per day, and the
weight of the companion animal is about 34 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
81
Date Recue/Date Received 2021-07-07
68. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 69 mg per day, and the
weight of the companion animal is about 34.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
69. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 70 mg per day, and the
weight of the companion animal is about 35 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
70. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 71 mg per day, and the
weight of the companion animal is about 35.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
82
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
71. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 72 mg per day, and the
weight of the companion animal is about 36 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
72. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 73 mg per day, and the
weight of the companion animal is about 36.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
73. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 74 mg per day, and the
weight of the companion animal is about 37 kg;
83
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
74. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 75 mg per day, and the
weight of the companion animal is about 37.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
75. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 76 mg per day, and the
weight of the companion animal is about 38 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
76. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
84
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 77 mg per day, and the
weight of the companion animal is about 38.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
77. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 78 mg per day, and the
weight of the companion animal is about 39 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
78. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 79 mg per day, and the
weight of the companion animal is about 39.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
79. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 80 mg per day, and the
weight of the companion animal is about 40 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
80. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 81 mg per day, and the
weight of the companion animal is about 40.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
81. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 82 mg per day, and the
weight of the companion animal is about 41 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
86
Date Recue/Date Received 2021-07-07
82. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 83 mg per day, and the
weight of the companion animal is about 41.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
83. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 84 mg per day, and the
weight of the companion animal is about 42 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
84. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 85 mg per day, and the
weight of the companion animal is about 42.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
87
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
85. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 86 mg per day, and the
weight of the companion animal is about 43 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
86. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 87 mg per day, and the
weight of the companion animal is about 43.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
87. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 88 mg per day, and the
weight of the companion animal is about 44 kg;
88
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
88. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 89 mg per day, and the
weight of the companion animal is about 44.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
89. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 90 mg per day, and the
weight of the companion animal is about 45 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
90. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
89
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 91 mg per day, and the
weight of the companion animal is about 45.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
91. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 92 mg per day, and the
weight of the companion animal is about 46 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
92. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 93 mg per day, and the
weight of the companion animal is about 46.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
93. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
Date Recue/Date Received 2021-07-07
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 94 mg per day, and the
weight of the companion animal is about 47 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
94. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 95 mg per day, and the
weight of the companion animal is about 47.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
95. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 96 mg per day, and the
weight of the companion animal is about 48 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
91
Date Recue/Date Received 2021-07-07
96. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion aninial in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 97 mg per day, and the
weight of the companion animal is about 48.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
97. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 98 mg per day, and the
weight of the companion animal is about 49 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
98. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 99 mg per day, and the
weight of the companion animal is about 49.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
92
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
99. Use of a pharmaceutical composition in the manufacture of a medicament for
treating pain or inflammation in a companion animal in need thereof, the
pharmaceutical composition comprising a therapeutically effective amount of
grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 100 mg per day, and
the weight of the companion animal is about 50 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
100. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 2.5 mg per day, and
the weight of the companion animal is about 1 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
101. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 3.75 mg per day, and
the weight of the companion animal is about 1.5 kg;
93
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
102. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 5 mg per day, and the
weight of the companion animal is about 2 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
103. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 6.25 mg per day, and
the weight of the companion animal is about 2.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
104. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
94
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 7.5 mg per day, and
the weight of the companion animal is about 3 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
105. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 8.75 mg per day, and
the weight of the companion animal is about 3.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
106. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 10 mg per day, and the
weight of the companion animal is about 4 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
107. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 11.25 mg per day, and
the weight of the companion animal is about 4.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
108. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 12.5 mg per day, and
the weight of the companion animal is about 5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
109. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 13.75 mg per day, and
the weight of the companion animal is about 5.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
96
Date Recue/Date Received 2021-07-07
110. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 15 mg per day, and the
weight of the companion animal is about 6 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
111. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 16.25 mg per day, and
the weight of the companion animal is about 6.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
112. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 17.5 mg per day, and
the weight of the companion animal is about 7 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
97
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
113. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 18.75 mg per day, and
the weight of the companion animal is about 7.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
114. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 20 mg per day, and the
weight of the companion animal is about 8 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
115. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 21.25 mg per day, and
the weight of the companion animal is about 8.5 kg;
98
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
116. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 22.5 mg per day, and
the weight of the companion animal is about 9 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
117. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 23.75 mg per day, and
the weight of the companion animal is about 9.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
118. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
99
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 25 mg per day, and the
weight of the companion animal is about 10 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
119. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 26.25 mg per day, and
the weight of the companion animal is about 10.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
120. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 27.5 mg per day, and
the weight of the companion animal is about 11 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
121. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
100
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 28.75 mg per day, and
the weight of the companion animal is about 11.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
122. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 30 mg per day, and the
weight of the companion animal is about 12 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
123. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 31.25 mg per day, and
the weight of the companion animal is about 12.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
101
Date Recue/Date Received 2021-07-07
124. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 32.5 mg per day, and
the weight of the companion animal is about 13 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
125. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 33.75 mg per day, and
the weight of the companion animal is about 13.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
126. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 35 mg per day, and the
weight of the companion animal is about 14 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
102
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
127. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 36.25 mg per day, and
the weight of the companion animal is about 14.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
128. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 37.5 mg per day, and
the weight of the companion animal is about 15 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
129. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 38.75 mg per day, and
the weight of the companion animal is about 15.5 kg;
103
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
130. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 40 mg per day, and the
weight of the companion animal is about 16 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
131. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 41.25 mg per day, and
the weight of the companion animal is about 16.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
132. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
104
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 42.5 mg per day, and
the weight of the companion animal is about 17 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
133. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 43.75 mg per day, and
the weight of the companion animal is about 17.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
134. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 45 mg per day, and the
weight of the companion animal is about 18 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
135. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
105
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 46.25 mg per day, and
the weight of the companion animal is about 18.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
136. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 47.5 mg per day, and
the weight of the companion animal is about 19 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
137. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 48.75 mg per day, and
the weight of the companion animal is about 19.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
106
Date Recue/Date Received 2021-07-07
138. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 50 mg per day, and the
weight of the companion animal is about 20 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
139. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 51.25 mg per day, and
the weight of the companion animal is about 20.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
140. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 52.5 mg per day, and
the weight of the companion animal is about 21 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
107
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
141. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 53.75 mg per day, and
the weight of the companion animal is about 21.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
142. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 55 mg per day, and the
weight of the companion animal is about 22 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
143. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 56.25 mg per day, and
the weight of the companion animal is about 22.5 kg;
108
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
144. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 57.5 mg per day, and
the weight of the companion animal is about 23 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
145. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 58.75 mg per day, and
the weight of the companion animal is about 23.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
146. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
109
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 60 mg per day, and the
weight of the companion animal is about 24 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
147. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 61.25 mg per day, and
the weight of the companion animal is about 24.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
148. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 62.5 mg per day, and
the weight of the companion animal is about 25 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
149. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
110
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 63.75 mg per day, and
the weight of the companion animal is about 25.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
150. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 65 mg per day, and the
weight of the companion animal is about 26 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
151. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 66.25 mg per day, and
the weight of the companion animal is about 26.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
111
Date Recue/Date Received 2021-07-07
152. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 67.5 mg per day, and
the weight of the companion animal is about 27 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
153. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 68.75 mg per day, and
the weight of the companion animal is about 27.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
154. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 70 mg per day, and the
weight of the companion animal is about 28 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
112
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
155. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 71.25 mg per day, and
the weight of the companion animal is about 28.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
156. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 72.5 mg per day, and
the weight of the companion animal is about 29 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
157. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 73.75 mg per day, and
the weight of the companion animal is about 29.5 kg;
113
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
158. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 75 mg per day, and the
weight of the companion animal is about 30 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
159. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 76.25 mg per day, and
the weight of the companion animal is about 30.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
160. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
114
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 77.5 mg per day, and
the weight of the companion animal is about 31 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
161. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 78.75 mg per day, and
the weight of the companion animal is about 31.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
162. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 80 mg per day, and the
weight of the companion animal is about 32 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
163. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
115
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 81.25 mg per day, and
the weight of the companion animal is about 32.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
164. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 82.5 mg per day, and
the weight of the companion animal is about 33 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
165. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 83.75 mg per day, and
the weight of the companion animal is about 33.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
116
Date Recue/Date Received 2021-07-07
166. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 85 mg per day, and the
weight of the companion animal is about 34 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
167. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 86.25 mg per day, and
the weight of the companion animal is about 34.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
168. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 87.5 mg per day, and
the weight of the companion animal is about 35 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
117
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
169. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 88.75 mg per day, and
the weight of the companion animal is about 35.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
170. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 90 mg per day, and the
weight of the companion animal is about 36 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
171. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 91.25 mg per day, and
the weight of the companion animal is about 36.5 kg;
118
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
172. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 92.5 mg per day, and
the weight of the companion animal is about 37 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
173. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 93.75 mg per day, and
the weight of the companion animal is about 37.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
174. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
119
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 95 mg per day, and the
weight of the companion animal is about 38 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
175. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 96.25 mg per day, and
the weight of the companion animal is about 38.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
176. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 97.5 mg per day, and
the weight of the companion animal is about 39 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
177. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
120
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 98.75 mg per day, and
the weight of the companion animal is about 39.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
178. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 100 mg per day, and
the weight of the companion animal is about 40 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
179. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 101.25 mg per day,
and the weight of the companion animal is about 40.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
121
Date Recue/Date Received 2021-07-07
180. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 102.5 mg per day, and
the weight of the companion animal is about 41 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
181. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 103.75 mg per day,
and the weight of the companion animal is about 41.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
182. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 105 mg per day, and
the weight of the companion animal is about 42 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
122
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
183. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 106.25 mg per day,
and the weight of the companion animal is about 42.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
184. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 107.5 mg per day, and
the weight of the companion animal is about 43 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
185. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 108.75 mg per day,
and the weight of the companion animal is about 43.5 kg;
123
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
186. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 110 mg per day, and
the weight of the companion animal is about 44 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
187. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 111.25 mg per day,
and the weight of the companion animal is about 44.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
188. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
124
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 112.5 mg per day, and
the weight of the companion animal is about 45 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
189. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 113.75 mg per day,
and the weight of the companion animal is about 45.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
190. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 115 mg per day, and
the weight of the companion animal is about 46 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
191. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
125
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 116.25 mg per day,
and the weight of the companion animal is about 46.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
192. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 117.5 mg per day, and
the weight of the companion animal is about 47 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
193. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 118.75 mg per day,
and the weight of the companion animal is about 47.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
126
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194. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 120 mg per day, and
the weight of the companion animal is about 48 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
195. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 121.25 mg per day,
and the weight of the companion animal is about 48.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
196. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 122.5 mg per day, and
the weight of the companion animal is about 49 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
127
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
197. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 123.75 mg per day,
and the weight of the companion animal is about 49.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
198. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 125 mg per day, and
the weight of the companion animal is about 50 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
199. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 3 mg per day, and the
weight of the companion animal is about 1 kg;
128
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
200. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 4.5 mg per day, and
the weight of the companion animal is about 1.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
201. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 6 mg per day, and the
weight of the companion animal is about 2 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
202. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
129
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 7.5 mg per day, and
the weight of the companion animal is about 2.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
203. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 9 mg per day, and the
weight of the companion animal is about 3 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
204. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 10.5 mg per day, and
the weight of the companion animal is about 3.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
205. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
130
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 12 mg per day, and the
weight of the companion animal is about 4 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
206. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 13.5 mg per day, and
the weight of the companion animal is about 4.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
207. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 15 mg per day, and the
weight of the companion animal is about 5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
131
Date Recue/Date Received 2021-07-07
208. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 16.5 mg per day, and
the weight of the companion animal is about 5.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
209. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 18 mg per day, and the
weight of the companion animal is about 6 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
210. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 19.5 mg per day, and
the weight of the companion animal is about 6.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
132
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
211. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 21 mg per day, and the
weight of the companion animal is about 7 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
212. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 22.5 mg per day, and
the weight of the companion animal is about 7.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
213. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 24 mg per day, and the
weight of the companion animal is about 8 kg;
133
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
214. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 25.5 mg per day, and
the weight of the companion animal is about 8.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
215. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 27 mg per day, and the
weight of the companion animal is about 9 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
216. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
134
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 28.5 mg per day, and
the weight of the companion animal is about 9.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
217. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 30 mg per day, and the
weight of the companion animal is about 10 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
218. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 31.5 mg per day, and
the weight of the companion animal is about 10.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
219. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
135
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 33 mg per day, and the
weight of the companion animal is about 11 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
220. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 34.5 mg per day, and
the weight of the companion animal is about 11.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
221. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 36 mg per day, and the
weight of the companion animal is about 12 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
136
Date Recue/Date Received 2021-07-07
222. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 37.5 mg per day, and
the weight of the companion animal is about 12.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
223. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 39 mg per day, and the
weight of the companion animal is about 13 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
224. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 40.5 mg per day, and
the weight of the companion animal is about 13.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
137
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
225. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 42 mg per day, and the
weight of the companion animal is about 14 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
226. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 43.5 mg per day, and
the weight of the companion animal is about 14.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
227. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 45 mg per day, and the
weight of the companion animal is about 15 kg;
138
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
228. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 46.5 mg per day, and
the weight of the companion animal is about 15.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
229. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 48 mg per day, and the
weight of the companion animal is about 16 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
230. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
139
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 49.5 mg per day, and
the weight of the companion animal is about 16.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
231. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 51 mg per day, and the
weight of the companion animal is about 17 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
232. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 52.5 mg per day, and
the weight of the companion animal is about 17.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
233. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
140
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 54 mg per day, and the
weight of the companion animal is about 18 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
234. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 55.5 mg per day, and
the weight of the companion animal is about 18.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
235. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 57 mg per day, and the
weight of the companion animal is about 19 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
141
Date Recue/Date Received 2021-07-07
236. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 58.5 mg per day, and
the weight of the companion animal is about 19.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
237. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 60 mg per day, and the
weight of the companion animal is about 20 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
238. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 61.5 mg per day, and
the weight of the companion animal is about 20.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
142
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
239. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 63 mg per day, and the
weight of the companion animal is about 21 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
240. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 64.5 mg per day, and
the weight of the companion animal is about 21.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
241. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 66 mg per day, and the
weight of the companion animal is about 22 kg;
143
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
242. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 67.5 mg per day, and
the weight of the companion animal is about 22.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
243. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 69 mg per day, and the
weight of the companion animal is about 23 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
244. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
144
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 70.5 mg per day, and
the weight of the companion animal is about 23.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
245. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 72 mg per day, and the
weight of the companion animal is about 24 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
246. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 73.5 mg per day, and
the weight of the companion animal is about 24.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
247. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
145
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 75 mg per day, and the
weight of the companion animal is about 25 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
248. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 76.5 mg per day, and
the weight of the companion animal is about 25.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
249. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 78 mg per day, and the
weight of the companion animal is about 26 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
146
Date Recue/Date Received 2021-07-07
250. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 79.5 mg per day, and
the weight of the companion animal is about 26.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
251. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 81 mg per day, and the
weight of the companion animal is about 27 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
252. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 82.5 mg per day, and
the weight of the companion animal is about 27.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
147
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
253. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 84 mg per day, and the
weight of the companion animal is about 28 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
254. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 85.5 mg per day, and
the weight of the companion animal is about 28.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
255. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 87 mg per day, and the
weight of the companion animal is about 29 kg;
148
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
256. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 88.5 mg per day, and
the weight of the companion animal is about 29.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
257. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 90 mg per day, and the
weight of the companion animal is about 30 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
258. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
149
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 91.5 mg per day, and
the weight of the companion animal is about 30.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
259. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 93 mg per day, and the
weight of the companion animal is about 31 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
260. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 94.5 mg per day, and
the weight of the companion animal is about 31.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
261. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
150
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 96 mg per day, and the
weight of the companion animal is about 32 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
262. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 97.5 mg per day, and
the weight of the companion animal is about 32.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
263. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 99 mg per day, and the
weight of the companion animal is about 33 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
151
Date Recue/Date Received 2021-07-07
264. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 100.5 mg per day, and
the weight of the companion animal is about 33.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
265. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 102 mg per day, and
the weight of the companion animal is about 34 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
266. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 103.5 mg per day, and
the weight of the companion animal is about 34.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
152
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
267. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 105 mg per day, and
the weight of the companion animal is about 35 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
268. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 106.5 mg per day, and
the weight of the companion animal is about 35.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
269. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 108 mg per day, and
the weight of the companion animal is about 36 kg;
153
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
270. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 109.5 mg per day, and
the weight of the companion animal is about 36.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
271. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 111 mg per day, and
the weight of the companion animal is about 37 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
272. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
154
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 112.5 mg per day, and
the weight of the companion animal is about 37.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
273. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 114 mg per day, and
the weight of the companion animal is about 38 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
274. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 115.5 mg per day, and
the weight of the companion animal is about 38.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
275. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
155
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 117 mg per day, and
the weight of the companion animal is about 39 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
276. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 118.5 mg per day, and
the weight of the companion animal is about 39.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
277. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 120 mg per day, and
the weight of the companion animal is about 40 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
156
Date Recue/Date Received 2021-07-07
278. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 121.5 mg per day, and
the weight of the companion animal is about 40.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
279. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 123 mg per day, and
the weight of the companion animal is about 41 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
280. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 124.5 mg per day, and
the weight of the companion animal is about 41.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
157
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
281. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 126 mg per day, and
the weight of the companion animal is about 42 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
282. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 127.5 mg per day, and
the weight of the companion animal is about 42.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
283. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 129 mg per day, and
the weight of the companion animal is about 43 kg;
158
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
284. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 130.5 mg per day, and
the weight of the companion animal is about 43.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
285. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 132 mg per day, and
the weight of the companion animal is about 44 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
286. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
159
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 133.5 mg per day, and
the weight of the companion animal is about 44.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
287. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 135 mg per day, and
the weight of the companion animal is about 45 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
288. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 136.5 mg per day, and
the weight of the companion animal is about 45.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
289. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
160
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 138 mg per day, and
the weight of the companion animal is about 46 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
290. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 139.5 mg per day, and
the weight of the companion animal is about 46.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
291. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 141 mg per day, and
the weight of the companion animal is about 47 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
161
Date Recue/Date Received 2021-07-07
292. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 142.5 mg per day, and
the weight of the companion animal is about 47.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
293. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 144 mg per day, and
the weight of the companion animal is about 48 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
294. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 145.5 mg per day, and
the weight of the companion animal is about 48.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
162
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
295. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 147 mg per day, and
the weight of the companion animal is about 49 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
296. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 148.5 mg per day, and
the weight of the companion animal is about 49.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
297. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 150 mg per day, and
the weight of the companion animal is about 50 kg;
163
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
298. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 3.5 mg per day, and
the weight of the companion animal is about 1 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
299. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 5.25 mg per day, and
the weight of the companion animal is about 1.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
300. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
164
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 7 mg per day, and the
weight of the companion animal is about 2 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
301. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 8.75 mg per day, and
the weight of the companion animal is about 2.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
302. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 10.5 mg per day, and
the weight of the companion animal is about 3 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
303. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
165
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 12.25 mg per day, and
the weight of the companion animal is about 3.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
304. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 14 mg per day, and the
weight of the companion animal is about 4 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
305. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 15.75 mg per day, and
the weight of the companion animal is about 4.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
166
Date Recue/Date Received 2021-07-07
306. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 17.5 mg per day, and
the weight of the companion animal is about 5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
307. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 19.25 mg per day, and
the weight of the companion animal is about 5.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
308. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 21 mg per day, and the
weight of the companion animal is about 6 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
167
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
309. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 22.75 mg per day, and
the weight of the companion animal is about 6.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
310. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 24.5 mg per day, and
the weight of the companion animal is about 7 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
311. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 26.25 mg per day, and
the weight of the companion animal is about 7.5 kg;
168
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
312. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 28 mg per day, and the
weight of the companion animal is about 8 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
313. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 29.75 mg per day, and
the weight of the companion animal is about 8.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
314. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
169
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 31.5 mg per day, and
the weight of the companion animal is about 9 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
315. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 33.25 mg per day, and
the weight of the companion animal is about 9.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
316. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 35 mg per day, and the
weight of the companion animal is about 10 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
317. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
170
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 36.75 mg per day, and
the weight of the companion animal is about 10.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
318. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 38.5 mg per day, and
the weight of the companion animal is about 11 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
319. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is 40.25 mg per day, and the
weight of the companion animal is about 11.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
171
Date Recue/Date Received 2021-07-07
320. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 42 mg per day, and the
weight of the companion animal is about 12 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
321. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 43.75 mg per day, and
the weight of the companion animal is about 12.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
322. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 45.5 mg per day, and
the weight of the companion animal is about 13 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
172
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
323. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 47.25 mg per day, and
the weight of the companion animal is about 13.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
324. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 49 mg per day, and the
weight of the companion animal is about 14 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
325. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 50.75 mg per day, and
the weight of the companion animal is about 14.5 kg;
173
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
326. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 52.5 mg per day, and
the weight of the companion animal is about 15 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
327. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 54.25 mg per day, and
the weight of the companion animal is about 15.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
328. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
174
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 56 mg per day, and the
weight of the companion animal is about 16 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
329. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 57.75 mg per day, and
the weight of the companion animal is about 16.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
330. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 59.5 mg per day, and
the weight of the companion animal is about 17 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
331. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
175
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 61.25 mg per day, and
the weight of the companion animal is about 17.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
332. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 63 mg per day, and the
weight of the companion animal is about 18 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
333. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 64.75 mg per day, and
the weight of the companion animal is about 18.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
176
Date Recue/Date Received 2021-07-07
334. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 66.5 mg per day, and
the weight of the companion animal is about 19 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
335. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 68.25 mg per day, and
the weight of the companion animal is about 19.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
336. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 70 mg per day, and the
weight of the companion animal is about 20 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
177
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
337. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 71.75 mg per day, and
the weight of the companion animal is about 20.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
338. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 73.5 mg per day, and
the weight of the companion animal is about 21 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
339. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 75.25 mg per day, and
the weight of the companion animal is about 21.5 kg;
178
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
340. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 77 mg per day, and the
weight of the companion animal is about 22 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
341. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 78.75 mg per day, and
the weight of the companion animal is about 22.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
342. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
179
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 80.5 mg per day, and
the weight of the companion animal is about 23 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
343. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 82.25 mg per day, and
the weight of the companion animal is about 23.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
344. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 84 mg per day, and the
weight of the companion animal is about 24 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
345. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
180
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 85.75 mg per day, and
the weight of the companion animal is about 24.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
346. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 87.5 mg per day, and
the weight of the companion animal is about 25 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
347. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 89.25 mg per day, and
the weight of the companion animal is about 25.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
181
Date Recue/Date Received 2021-07-07
348. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 91 mg per day, and the
weight of the companion animal is about 26 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
349. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 92.75 mg per day, and
the weight of the companion animal is about 26.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
350. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 94.5 mg per day, and
the weight of the companion animal is about 27 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
182
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
351. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 96.25 mg per day, and
the weight of the companion animal is about 27.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
352. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 98 mg per day, and the
weight of the companion animal is about 28 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
353. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 99.75 mg per day, and
the weight of the companion animal is about 28.5 kg;
183
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
354. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 101.5 mg per day, and
the weight of the companion animal is about 29 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
355. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 103.25 mg per day,
and the weight of the companion animal is about 29.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
356. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
184
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 105 mg per day, and
the weight of the companion animal is about 30 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
357. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 106.75 mg per day,
and the weight of the companion animal is about 30.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
358. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 108.5 mg per day, and
the weight of the companion animal is about 31 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
359. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
185
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 110.25 mg per day,
and the weight of the companion animal is about 31.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
360. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 112 mg per day, and
the weight of the companion animal is about 32 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
361. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 113.75 mg per day,
and the weight of the companion animal is about 32.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
186
Date Recue/Date Received 2021-07-07
362. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 115.5 mg per day, and
the weight of the companion animal is about 33 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
363. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 117.25 mg per day,
and the weight of the companion animal is about 33.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
364. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 119 mg per day, and
the weight of the companion animal is about 34 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
187
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
365. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 120.75 mg per day,
and the weight of the companion animal is about 34.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
366. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 122.5 mg per day, and
the weight of the companion animal is about 35 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
367. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 124.25 mg per day,
and the weight of the companion animal is about 35.5 kg;
188
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
368. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 126 mg per day, and
the weight of the companion animal is about 36 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
369. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 127.75 mg per day,
and the weight of the companion animal is about 36.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
370. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
189
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 129.5 mg per day, and
the weight of the companion animal is about 37 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
371. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 131.25 mg per day,
and the weight of the companion animal is about 37.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
372. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 133 mg per day, and
the weight of the companion animal is about 38 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
373. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
190
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 134.75 mg per day,
and the weight of the companion animal is about 38.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
374. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 136.5 mg per day, and
the weight of the companion animal is about 39 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
375. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 138.25 mg per day,
and the weight of the companion animal is about 39.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
191
Date Recue/Date Received 2021-07-07
376. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 140 mg per day, and
the weight of the companion animal is about 40 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
377. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 141.75 mg per day,
and the weight of the companion animal is about 40.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
378. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 143.5 mg per day, and
the weight of the companion animal is about 41 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
192
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
379. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 145.25 mg per day,
and the weight of the companion animal is about 41.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
380. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 147 mg per day, and
the weight of the companion animal is about 42 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
381. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 148.75 mg per day,
and the weight of the companion animal is about 42.5 kg;
193
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
382. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 150.5 mg per day, and
the weight of the companion animal is about 43 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
383. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 152.25 mg per day,
and the weight of the companion animal is about 43.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
384. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
194
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 154 mg per day, and
the weight of the companion animal is about 44 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
385. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 155.75 mg per day,
and the weight of the companion animal is about 44.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
386. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 157.5 mg per day, and
the weight of the companion animal is about 45 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
387. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
195
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 159.25 mg per day,
and the weight of the companion animal is about 45.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
388. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 161 mg per day, and
the weight of the companion animal is about 46 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
389. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 162.75 mg per day,
and the weight of the companion animal is about 46.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
196
Date Recue/Date Received 2021-07-07
390. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 164.5 mg per day, and
the weight of the companion animal is about 47 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
391. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 166.25 mg per day,
and the weight of the companion animal is about 47.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
392. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 168 mg per day, and
the weight of the companion animal is about 48 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
197
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
393. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 169.75 mg per day,
and the weight of the companion animal is about 48.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
394. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 171.5 mg per day, and
the weight of the companion animal is about 49 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
395. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 173.25 mg per day,
and the weight of the companion animal is about 49.5 kg;
198
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
396. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 175 mg per day, and
the weight of the companion animal is about 50 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
397. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 4 mg per day, and the
weight of the companion animal is about 1 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
398. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
199
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 6 mg per day, and the
weight of the companion animal is about 1.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
399. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 8 mg per day, and the
weight of the companion animal is about 2 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
400. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 10 mg per day, and the
weight of the companion animal is about 2.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
401. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
200
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 12 mg per day, and the
weight of the companion animal is about 3 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
402. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 14 mg per day, and the
weight of the companion animal is about 3.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
403. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 16 mg per day, and the
weight of the companion animal is about 4 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
201
Date Recue/Date Received 2021-07-07
404. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 18 mg per day, and the
weight of the companion animal is about 4.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
405. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 20 mg per day, and the
weight of the companion animal is about 5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
406. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 22 mg per day, and the
weight of the companion animal is about 5.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
202
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
407. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 24 mg per day, and the
weight of the companion animal is about 6 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
408. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 26 mg per day, and the
weight of the companion animal is about 6.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
409. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 28 mg per day, and the
weight of the companion animal is about 7 kg;
203
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
410. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 30 mg per day, and the
weight of the companion animal is about 7.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
411. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 32 mg per day, and the
weight of the companion animal is about 8 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
412. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
204
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 34 mg per day, and the
weight of the companion animal is about 8.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
413. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 36 mg per day, and the
weight of the companion animal is about 9 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
414. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 38 mg per day, and the
weight of the companion animal is about 9.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
415. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
205
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 40 mg per day, and the
weight of the companion animal is about 10 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
416. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 42 mg per day, and the
weight of the companion animal is about 10.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
417. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 44 mg per day, and the
weight of the companion animal is about 11 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
206
Date Recue/Date Received 2021-07-07
418. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 46 mg per day, and the
weight of the companion animal is about 11.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
419. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 48 mg per day, and the
weight of the companion animal is about 12 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
420. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 50 mg per day, and the
weight of the companion animal is about 12.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
207
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
421. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 52 mg per day, and the
weight of the companion animal is about 13 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
422. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 54 mg per day, and the
weight of the companion animal is about 13.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
423. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 56 mg per day, and the
weight of the companion animal is about 14 kg;
208
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
424. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 58 mg per day, and the
weight of the companion animal is about 14.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
425. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 60 mg per day, and the
weight of the companion animal is about 15 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
426. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
209
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 62 mg per day, and the
weight of the companion animal is about 15.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
427. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 64 mg per day, and the
weight of the companion animal is about 16 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
428. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 66 mg per day, and the
weight of the companion animal is about 16.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
429. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
210
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 68 mg per day, and the
weight of the companion animal is about 17 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
430. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 70 mg per day, and the
weight of the companion animal is about 17.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
431. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 72 mg per day, and the
weight of the companion animal is about 18 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
211
Date Recue/Date Received 2021-07-07
432. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 74 mg per day, and the
weight of the companion animal is about 18.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
433. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 76 mg per day, and the
weight of the companion animal is about 19 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
434. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 78 mg per day, and the
weight of the companion animal is about 19.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
212
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
435. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 80 mg per day, and the
weight of the companion animal is about 20 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
436. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 82 mg per day, and the
weight of the companion animal is about 20.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
437. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 84 mg per day, and the
weight of the companion animal is about 21 kg;
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wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
438. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 86 mg per day, and the
weight of the companion animal is about 21.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
439. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 88 mg per day, and the
weight of the companion animal is about 22 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
440. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
214
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wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 90 mg per day, and the
weight of the companion animal is about 22.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
441. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 92 mg per day, and the
weight of the companion animal is about 23 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
442. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 94 mg per day, and the
weight of the companion animal is about 23.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
443. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
215
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 96 mg per day, and the
weight of the companion animal is about 24 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
444. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 98 mg per day, and the
weight of the companion animal is about 24.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
445. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 100 mg per day, and
the weight of the companion animal is about 25 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
216
Date Recue/Date Received 2021-07-07
446. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 102 mg per day, and
the weight of the companion animal is about 25.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
447. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 104 mg per day, and
the weight of the companion animal is about 26 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
448. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 106 mg per day, and
the weight of the companion animal is about 26.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
217
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
449. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 108 mg per day, and
the weight of the companion animal is about 27 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
450. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 110 mg per day, and
the weight of the companion animal is about 27.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
451. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 112 mg per day, and
the weight of the companion animal is about 28 kg;
218
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
452. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 114 mg per day, and
the weight of the companion animal is about 28.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
453. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 116 mg per day, and
the weight of the companion animal is about 29 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
454. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
219
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 118 mg per day, and
the weight of the companion animal is about 29.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
455. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 120 mg per day, and
the weight of the companion animal is about 30 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
456. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 122 mg per day, and
the weight of the companion animal is about 30.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
457. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
220
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 124 mg per day, and
the weight of the companion animal is about 31 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
458. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 126 mg per day, and
the weight of the companion animal is about 31.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
459. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 128 mg per day, and
the weight of the companion animal is about 32 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
221
Date Recue/Date Received 2021-07-07
460. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 130 mg per day, and
the weight of the companion animal is about 32.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
461. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 132 mg per day, and
the weight of the companion animal is about 33 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
462. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 134 mg per day, and
the weight of the companion animal is about 33.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
222
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
463. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 136 mg per day, and
the weight of the companion animal is about 34 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
464. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 138 mg per day, and
the weight of the companion animal is about 34.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
465. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 140 mg per day, and
the weight of the companion animal is about 35 kg;
223
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
466. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 142 mg per day, and
the weight of the companion animal is about 35.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
467. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 144 mg per day, and
the weight of the companion animal is about 36 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
468. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
224
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 146 mg per day, and
the weight of the companion animal is about 36.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
469. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 148 mg per day, and
the weight of the companion animal is about 37 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
470. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 150 mg per day, and
the weight of the companion animal is about 37.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
471. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
225
Date Recue/Date Received 2021-07-07
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 152 mg per day, and
the weight of the companion animal is about 38 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
472. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 154 mg per day, and
the weight of the companion animal is about 38.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
473. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 156 mg per day, and
the weight of the companion animal is about 39 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
226
Date Recue/Date Received 2021-07-07
474. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 158 mg per day, and
the weight of the companion animal is about 39.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
475. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 160 mg per day, and
the weight of the companion animal is about 40 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
476. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 162 mg per day, and
the weight of the companion animal is about 40.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
227
Date Recue/Date Received 2021-07-07
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
477. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 164 mg per day, and
the weight of the companion animal is about 41 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
478. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 166 mg per day, and
the weight of the companion animal is about 41.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
479. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 168 mg per day, and
the weight of the companion animal is about 42 kg;
228
Date Recue/Date Received 2021-07-07
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
480. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 170 mg per day, and
the weight of the companion animal is about 42.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
481. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 172 mg per day, and
the weight of the companion animal is about 43 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
482. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
229
Date Recue/Date Received 2021-07-07
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 174 mg per day, and
the weight of the companion animal is about 43.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
483. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 176 mg per day, and
the weight of the companion animal is about 44 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
484. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 178 mg per day, and
the weight of the companion animal is about 44.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
485. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
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thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 180 mg per day, and
the weight of the companion animal is about 45 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
486. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 182 mg per day, and
the weight of the companion animal is about 45.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
487. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 184 mg per day, and
the weight of the companion animal is about 46 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
231
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488. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 186 mg per day, and
the weight of the companion animal is about 46.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
489. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 188 mg per day, and
the weight of the companion animal is about 47 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
490. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 190 mg per day, and
the weight of the companion animal is about 47.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
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consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
491. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 192 mg per day, and
the weight of the companion animal is about 48 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
492. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 194 mg per day, and
the weight of the companion animal is about 48.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
493. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 196 mg per day, and
the weight of the companion animal is about 49 kg;
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wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
494. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 198 mg per day, and
the weight of the companion animal is about 49.5 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
495. Use of a pharmaceutical composition in the manufacture of a
medicament for treating pain or inflammation in a companion animal in need
thereof, the pharmaceutical composition comprising a therapeutically
effective amount of grapiprant and an excipient;
wherein the medicament is formulated for oral administration, the
therapeutically effective amount of grapiprant is about 200 mg per day, and
the weight of the companion animal is about 50 kg;
wherein the use causes no clinically significant adverse gastrointestinal
effects or changes in drug related effects in mortality, body weight, food
consumption, ophthalmology, electrocardiogram, hematology, coagulation, or
gross pathological findings in the companion animal.
496. The use of any one of claims 1 to 495, wherein the medicament achieves
a Cmax of grapiprant of 375 ng/mL tO 10000 ng/mL at a Tmax of 0.4 to 3.4
hours.
234
Date Recue/Date Received 2021-07-07
497. The use of any one of claims 1 to 495, wherein the medicament achieves
a Cmax of grapiprant of 675 ng/mL to 5000 ng/niL within 4 hours after
administration and a half-life of less than 14 hours.
498. The use of any one of claims 1 to 497, wherein the medicament achieves
a Cmax of grapiprant of 750 ng/mL to 4000 ng/mL.
499. The use of any one of claims 1 to 497, wherein the medicament achieves
a Cmax of grapiprant of 1300 ng/mL to 4000 ng/mL.
500. The use of any one of claims 1 to 499, wherein the medicament achieves
the Cmax of grapiprant at a Tmax of 0.7 to 1.7 hours.
501. The use of any one of claims 1 to 499, wherein the medicament achieves
the Cmax of grapiprant at a Tmax of 0.5 to 1.0 hours.
502. The use of any one of claims 496 to 501, wherein the Cmax is achieved
within 1 hour after administration.
503. The use of any one of claims 1 to 502, wherein the pharmaceutical
composition further comprises 1% to 30% flavorant w/w of the total
composition.
504. The use of any one of claims 1 to 502, wherein the pharmaceutical
composition comprises 5% to 15% flavorant w/w of the total composition.
505. The use of any one of claims 1 to 504, wherein the pharmaceutical
composition is for administration at least once daily.
506. The use of any one of claims 1 to 504, wherein the pharmaceutical
composition is for administration at least twice daily.
507. The use of any one of claims 1 to 506, wherein the pharmaceutical
composition is for administration for 6 days to 9 months.
508. The use of any one of claims 1 to 506, wherein the pharmaceutical
composition is for administration for 9 to 21 days.
235
Date Recue/Date Received 2021-07-07
509. The use of any one of claims 1 to 506, wherein the pharmaceutical
composition is for administration for 12 to 14 days.
510. The use of any one of claims 1 to 506, wherein the the pharmaceutical
composition is for administration once daily for 28 days.
511. The use of any one of claims 1 to 506, wherein the pharmaceutical
composition is for administration once daily for 9 to 21 days.
512. The use of any one of claims 1 to 506, wherein the pharmaceutical
composition is for administration twice daily for 9 to 21 days.
513. The use of any one of claims 1 to 504, wherein the medicament is for
administration from about 10 hours to about 18 hours before a surgery is
performed on the companion animal.
514. The use of any one of claims 1 to 513, wherein the companion animal is
a dog or a cat.
515. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 2 mg per
day, and weight of the companion animal is about 1 kg.;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
516. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
236
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 3 mg per
day, and weight of the companion animal is about 1.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
517. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 4 mg per
day, and weight of the companion animal is about 2 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
518. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 5 mg per
day, and weight of the companion animal is about 2.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
519. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
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Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 6 mg per
day, and weight of the companion animal is about 3 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
520. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 7 mg per
day, and weight of the companion animal is about 3.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
521. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 8 mg per
day, and weight of the companion animal is about 4 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
238
Date Recue/Date Received 2021-07-07
522. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 9 mg per
day, and weight of the companion animal is about 4.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
523. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 10 mg per
day, and weight of the companion animal is about 5 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
524. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 11 mg per
day, and weight of the companion animal is about 5.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
239
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weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
525. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 12 mg per
day, and weight of the companion animal is about 6 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
526. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 13 mg per
day, and weight of the companion animal is about 6.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
527. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 14 mg per
day, and weight of the companion animal is about 7 kg:,
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Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
528. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 15 mg per
day, and weight of the companion animal is about 7.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
529. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 16 mg per
day, and weight of the companion animal is about 8 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
530. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
241
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 17 mg per
day, and weight of the companion animal is about 8.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
531. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 18 mg per
day, and weight of the companion animal is about 9 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
532. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 19 mg per
day, and weight of the companion animal is about 9.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
533. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
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Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 20 mg per
day, and weight of the companion animal is about 10 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
534. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 21 mg per
day, and weight of the companion animal is about 10.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
535. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 22 mg per
day, and weight of the companion animal is about 11 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
243
Date Recue/Date Received 2021-07-07
536. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 23 mg per
day, and weight of the companion animal is about 11.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
537. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 24 mg per
day, and weight of the companion animal is about 12 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
538. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 25 mg per
day, and weight of the companion animal is about 12.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
244
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
539. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 26 mg per
day, and weight of the companion animal is about 13 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
540. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 27 mg per
day, and weight of the companion animal is about 13.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
541. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 28 mg per
day, and weight of the companion animal is about 14 kg:,
245
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
542. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 29 mg per
day, and weight of the companion animal is about 14.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
543. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 30 mg per
day, and weight of the companion animal is about 15 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
544. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
246
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 31 mg per
day, and weight of the companion animal is about 15.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
545. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 32 mg per
day, and weight of the companion animal is about 16 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
546. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 33 mg per
day, and weight of the companion animal is about 16.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
547. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
247
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 34 mg per
day, and weight of the companion animal is about 17 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
548. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 35 mg per
day, and weight of the companion animal is about 17.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
549. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 36 mg per
day, and weight of the companion animal is about 18 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
248
Date Recue/Date Received 2021-07-07
550. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 37 mg per
day, and weight of the companion animal is about 18.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
551. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 38 mg per
day, and weight of the companion animal is about 19 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
552. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 39 mg per
day, and weight of the companion animal is about 19.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
249
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
553. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 40 mg per
day, and weight of the companion animal is about 20 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
554. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 41 mg per
day, and weight of the companion animal is about 20.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
555. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 42 mg per
day, and weight of the companion animal is about 21 kg:,
250
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
556. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 43 mg per
day, and weight of the companion animal is about 21.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
557. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 44 mg per
day, and weight of the companion animal is about 22 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
558. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
251
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 45 mg per
day, and weight of the companion animal is about 22.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
559. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 46 mg per
day, and weight of the companion animal is about 23 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
560. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 47 mg per
day, and weight of the companion animal is about 23.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
561. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
252
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 48 mg per
day, and weight of the companion animal is about 24 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
562. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 49 mg per
day, and weight of the companion animal is about 24.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
563. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 50 mg per
day, and weight of the companion animal is about 25 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
253
Date Recue/Date Received 2021-07-07
564. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 51 mg per
day, and weight of the companion animal is about 25.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
565. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 52 mg per
day, and weight of the companion animal is about 26 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
566. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 53 mg per
day, and weight of the companion animal is about 26.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
254
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
567. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 54 mg per
day, and weight of the companion animal is about 27 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
568. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 55 mg per
day, and weight of the companion animal is about 27.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
569. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 56 mg per
day, and weight of the companion animal is about 28 kg:,
255
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
570. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 57 mg per
day, and weight of the companion animal is about 28.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
571. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 58 mg per
day, and weight of the companion animal is about 29 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
572. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
256
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 59 mg per
day, and weight of the companion animal is about 29.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
573. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 60 mg per
day, and weight of the companion animal is about 30 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
574. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 61 mg per
day, and weight of the companion animal is about 30.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
575. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
257
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 62 mg per
day, and weight of the companion animal is about 31 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
576. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 63 mg per
day, and weight of the companion animal is about 31.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
577. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 64 mg per
day, and weight of the companion animal is about 32 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
258
Date Recue/Date Received 2021-07-07
578. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 65 mg per
day, and weight of the companion animal is about 32.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
579. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 66 mg per
day, and weight of the companion animal is about 33 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
580. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 67 mg per
day, and weight of the companion animal is about 33.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
259
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
581. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 68 mg per
day, and weight of the companion animal is about 34 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
582. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 69 mg per
day, and weight of the companion animal is about 34.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
583. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 70 mg per
day, and weight of the companion animal is about 35 kg:,
260
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
584. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 71 mg per
day, and weight of the companion animal is about 35.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
585. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 72 mg per
day, and weight of the companion animal is about 36 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
586. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
261
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 73 mg per
day, and weight of the companion animal is about 36.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
587. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 74 mg per
day, and weight of the companion animal is about 37 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
588. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 75 mg per
day, and weight of the companion animal is about 37.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
589. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
262
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 76 mg per
day, and weight of the companion animal is about 38 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
590. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 77 mg per
day, and weight of the companion animal is about 38.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
591. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 78 mg per
day, and weight of the companion animal is about 39 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
263
Date Recue/Date Received 2021-07-07
592. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 79 mg per
day, and weight of the companion animal is about 39.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
593. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 80 mg per
day, and weight of the companion animal is about 40 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
594. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 81 mg per
day, and weight of the companion animal is about 40.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
264
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
595. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 82 mg per
day, and weight of the companion animal is about 41 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
596. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 83 mg per
day, and weight of the companion animal is about 41.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
597. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 84 mg per
day, and weight of the companion animal is about 42 kg:,
265
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
598. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 85 mg per
day, and weight of the companion animal is about 42.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
599. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 86 mg per
day, and weight of the companion animal is about 43 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
600. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
266
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 87 mg per
day, and weight of the companion animal is about 43.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
601. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 88 mg per
day, and weight of the companion animal is about 44 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
602. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 89 mg per
day, and weight of the companion animal is about 44.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
603. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
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0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 90 mg per
day, and weight of the companion animal is about 45 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
604. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 91 mg per
day, and weight of the companion animal is about 45.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
605. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 92 mg per
day, and weight of the companion animal is about 46 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
268
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606. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 93 mg per
day, and weight of the companion animal is about 46.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
607. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 94 mg per
day, and weight of the companion animal is about 47 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
608. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 95 mg per
day, and weight of the companion animal is about 47.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
269
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
609. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 96 mg per
day, and weight of the companion animal is about 48 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
610. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 97 mg per
day, and weight of the companion animal is about 48.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
611. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 98 mg per
day, and weight of the companion animal is about 49 kg:,
270
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
612. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 99 mg per
day, and weight of the companion animal is about 49.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
613. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 100 mg
per day, and weight of the companion animal is about 50 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
614. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
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Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 2.5 mg per
day, and weight of the companion animal is about 1 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
615. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 3.75 mg
per day, and weight of the companion animal is about 1.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
616. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 5 mg per
day, and weight of the companion animal is about 2 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
617. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
272
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 6.25 mg
per day, and weight of the companion animal is about 2.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
618. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 7.5 mg per
day, and weight of the companion animal is about 3 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
619. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 8.75 mg
per day, and weight of the companion animal is about 3.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
273
Date Recue/Date Received 2021-07-07
620. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 10 mg per
day, and weight of the companion animal is about 4 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
621. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 11.25 mg
per day, and weight of the companion animal is about 4.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
622. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 12.5 mg
per day, and weight of the companion animal is about 5 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
274
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
623. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 13.75 mg
per day, and weight of the companion animal is about 5.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
624. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 15 mg per
day, and weight of the companion animal is about 6 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
625. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 16.25 mg
per day, and weight of the companion animal is about 6.5 kgi
275
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
626. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 17.5 mg
per day, and weight of the companion animal is about 7 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
627. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 18.75 mg
per day, and weight of the companion animal is about 7.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
628. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
276
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 20 mg per
day, and weight of the companion animal is about 8 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
629. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 21.25 mg
per day, and weight of the companion animal is about 8.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
630. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 22.5 mg
per day, and weight of the companion animal is about 9 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
631. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
277
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 23.75 mg
per day, and weight of the companion animal is about 9.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
632. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 25 mg per
day, and weight of the companion animal is about 10 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
633. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 26.25 mg
per day, and weight of the companion animal is about 10.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
278
Date Recue/Date Received 2021-07-07
634. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 27.5 mg
per day, and weight of the companion animal is about 11 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
635. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 28.75 mg
per day, and weight of the companion animal is about 11.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
636. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 30 mg per
day, and weight of the companion animal is about 12 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
279
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
637. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 31.25 mg
per day, and weight of the companion animal is about 12.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
638. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 32.5 mg
per day, and weight of the companion animal is about 13 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
639. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 33.75 mg
per day, and weight of the companion animal is about 13.5 kgi
280
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
640. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 35 mg per
day, and weight of the companion animal is about 14 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
641. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 36.25 mg
per day, and weight of the companion animal is about 14.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
642. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
281
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 37.5 mg
per day, and weight of the companion animal is about 15 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
643. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 38.75 mg
per day, and weight of the companion animal is about 15.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
644. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 40 mg per
day, and weight of the companion animal is about 16 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
645. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
282
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 41.25 mg
per day, and weight of the companion animal is about 16.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
646. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 42.5 mg
per day, and weight of the companion animal is about 17 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
647. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 43.75 mg
per day, and weight of the companion animal is about 17.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
283
Date Recue/Date Received 2021-07-07
648. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 45 mg per
day, and weight of the companion animal is about 18 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
649. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 46.25 mg
per day, and weight of the companion animal is about 18.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
650. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 47.5 mg
per day, and weight of the companion animal is about 19 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
284
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
651. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 48.75 mg
per day, and weight of the companion animal is about 19.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
652. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 50 mg per
day, and weight of the companion animal is about 20 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
653. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 51.25 mg
per day, and weight of the companion animal is about 20.5 kgi
285
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
654. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 52.5 mg
per day, and weight of the companion animal is about 21 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
655. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 53.75 mg
per day, and weight of the companion animal is about 21.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
656. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
286
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 55 mg per
day, and weight of the companion animal is about 22 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
657. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 56.25 mg
per day, and weight of the companion animal is about 22.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
658. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 57.5 mg
per day, and weight of the companion animal is about 23 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
659. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
287
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 58.75 mg
per day, and weight of the companion animal is about 23.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
660. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 60 mg per
day, and weight of the companion animal is about 24 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
661. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 61.25 mg
per day, and weight of the companion animal is about 24.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
288
Date Recue/Date Received 2021-07-07
662. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 62.5 mg
per day, and weight of the companion animal is about 25 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
663. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 63.75 mg
per day, and weight of the companion animal is about 25.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
664. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 65 mg per
day, and weight of the companion animal is about 26 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
289
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
665. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 66.25 mg
per day, and weight of the companion animal is about 26.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
666. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 67.5 mg
per day, and weight of the companion animal is about 27 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
667. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 68.75 mg
per day, and weight of the companion animal is about 27.5 kgi
290
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
668. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 70 mg per
day, and weight of the companion animal is about 28 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
669. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 71.25 mg
per day, and weight of the companion animal is about 28.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
670. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
291
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 72.5 mg
per day, and weight of the companion animal is about 29 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
671. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 73.75 mg
per day, and weight of the companion animal is about 29.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
672. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 75 mg per
day, and weight of the companion animal is about 30 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
673. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
292
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 76.25 mg
per day, and weight of the companion animal is about 30.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
674. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 77.5 mg
per day, and weight of the companion animal is about 31 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
675. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 78.75 mg
per day, and weight of the companion animal is about 31.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
293
Date Recue/Date Received 2021-07-07
676. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 80 mg per
day, and weight of the companion animal is about 32 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
677. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 81.25 mg
per day, and weight of the companion animal is about 32.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
678. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 82.5 mg
per day, and weight of the companion animal is about 33 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
294
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
679. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 83.75 mg
per day, and weight of the companion animal is about 33.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
680. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 85 mg per
day, and weight of the companion animal is about 34 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
681. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 86.25 mg
per day, and weight of the companion animal is about 34.5 kgi
295
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
682. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 87.5 mg
per day, and weight of the companion animal is about 35 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
683. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 88.75 mg
per day, and weight of the companion animal is about 35.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
684. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
296
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 90 mg per
day, and weight of the companion animal is about 36 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
685. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 91.25 mg
per day, and weight of the companion animal is about 36.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
686. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 92.5 mg
per day, and weight of the companion animal is about 37 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
687. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
297
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 93.75 mg
per day, and weight of the companion animal is about 37.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
688. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 95 mg per
day, and weight of the companion animal is about 38 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
689. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 96.25 mg
per day, and weight of the companion animal is about 38.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
298
Date Recue/Date Received 2021-07-07
690. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 97.5 mg
per day, and weight of the companion animal is about 39 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
691. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 98.75 mg
per day, and weight of the companion animal is about 39.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
692. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 100 mg
per day, and weight of the companion animal is about 40 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
299
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
693. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 101.25 mg
per day, and weight of the companion animal is about 40.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
694. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 102.5 mg
per day, and weight of the companion animal is about 41 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
695. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 103.75 mg
per day, and weight of the companion animal is about 41.5 kgi
300
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
696. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 105 mg
per day, and weight of the companion animal is about 42 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
697. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 106.25 mg
per day, and weight of the companion animal is about 42.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
698. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
301
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 107.5 mg
per day, and weight of the companion animal is about 43 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
699. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 108.75 mg
per day, and weight of the companion animal is about 43.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
700. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 110 mg
per day, and weight of the companion animal is about 44 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
701. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
302
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 111.25 mg
per day, and weight of the companion animal is about 44.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
702. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 112.5 mg
per day, and weight of the companion animal is about 45 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
703. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 113.75 mg
per day, and weight of the companion animal is about 45.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
303
Date Recue/Date Received 2021-07-07
704. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 115 mg
per day, and weight of the companion animal is about 46 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
705. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 116.25 mg
per day, and weight of the companion animal is about 46.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
706. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 117.5 mg
per day, and weight of the companion animal is about 47 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
304
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
707. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 118.75 mg
per day, and weight of the companion animal is about 47.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
708. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 120 mg
per day, and weight of the companion animal is about 48 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
709. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 121.25 mg
per day, and weight of the companion animal is about 48.5 kgi
305
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
710. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 122.5 mg
per day, and weight of the companion animal is about 49 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
711. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 123.75 mg
per day, and weight of the companion animal is about 49.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
712. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
306
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 125 mg
per day, and weight of the companion animal is about 50 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
713. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 3 mg per
day, and weight of the companion animal is about 1 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
714. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 4.5 mg per
day, and weight of the companion animal is about 1.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
715. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
307
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 6 mg per
day, and weight of the companion animal is about 2 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
716. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 7.5 mg per
day, and weight of the companion animal is about 2.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
717. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 9 mg per
day, and weight of the companion animal is about 3 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
308
Date Recue/Date Received 2021-07-07
718. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 10.5 mg
per day, and weight of the companion animal is about 3.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
719. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 12 mg per
day, and weight of the companion animal is about 4 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
720. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 13.5 mg
per day, and weight of the companion animal is about 4.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
309
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
721. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 15 mg per
day, and weight of the companion animal is about 5 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
722. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 16.5 mg
per day, and weight of the companion animal is about 5.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
723. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 18 mg per
day, and weight of the companion animal is about 6 kg:,
310
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
724. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 19.5 mg
per day, and weight of the companion animal is about 6.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
725. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 21 mg per
day, and weight of the companion animal is about 7 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
726. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
311
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 22.5 mg
per day, and weight of the companion animal is about 7.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
727. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 24 mg per
day, and weight of the companion animal is about 8 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
728. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 25.5 mg
per day, and weight of the companion animal is about 8.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
729. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
312
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 27 mg per
day, and weight of the companion animal is about 9 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
730. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 28.5 mg
per day, and weight of the companion animal is about 9.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
731. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 30 mg per
day, and weight of the companion animal is about 10 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
313
Date Recue/Date Received 2021-07-07
732. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 31.5 mg
per day, and weight of the companion animal is about 10.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
733. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 33 mg per
day, and weight of the companion animal is about 11 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
734. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 34.5 mg
per day, and weight of the companion animal is about 11.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
314
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
735. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 36 mg per
day, and weight of the companion animal is about 12 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
736. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 37.5 mg
per day, and weight of the companion animal is about 12.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
737. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 39 mg per
day, and weight of the companion animal is about 13 kg:,
315
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
738. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 40.5 mg
per day, and weight of the companion animal is about 13.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
739. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 42 mg per
day, and weight of the companion animal is about 14 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
740. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
316
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 43.5 mg
per day, and weight of the companion animal is about 14.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
741. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 45 mg per
day, and weight of the companion animal is about 15 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
742. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 46.5 mg
per day, and weight of the companion animal is about 15.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
743. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
317
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 48 mg per
day, and weight of the companion animal is about 16 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
744. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 49.5 mg
per day, and weight of the companion animal is about 16.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
745. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 51 mg per
day, and weight of the companion animal is about 17 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
318
Date Recue/Date Received 2021-07-07
746. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 52.5 mg
per day, and weight of the companion animal is about 17.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
747. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 54 mg per
day, and weight of the companion animal is about 18 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
748. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 55.5 mg
per day, and weight of the companion animal is about 18.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
319
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
749. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 57 mg per
day, and weight of the companion animal is about 19 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
750. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 58.5 mg
per day, and weight of the companion animal is about 19.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
751. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 60 mg per
day, and weight of the companion animal is about 20 kg:,
320
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
752. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 61.5 mg
per day, and weight of the companion animal is about 20.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
753. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 63 mg per
day, and weight of the companion animal is about 21 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
754. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
321
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 64.5 mg
per day, and weight of the companion animal is about 21.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
755. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 66 mg per
day, and weight of the companion animal is about 22 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
756. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 67.5 mg
per day, and weight of the companion animal is about 22.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
757. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
322
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 69 mg per
day, and weight of the companion animal is about 23 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
758. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 70.5 mg
per day, and weight of the companion animal is about 23.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
759. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 72 mg per
day, and weight of the companion animal is about 24 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
323
Date Recue/Date Received 2021-07-07
760. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 73.5 mg
per day, and weight of the companion animal is about 24.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
761. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 75 mg per
day, and weight of the companion animal is about 25 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
762. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 76.5 mg
per day, and weight of the companion animal is about 25.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
324
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
763. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 78 mg per
day, and weight of the companion animal is about 26 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
764. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 79.5 mg
per day, and weight of the companion animal is about 26.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
765. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 81 mg per
day, and weight of the companion animal is about 27 kg:,
325
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
766. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 82.5 mg
per day, and weight of the companion animal is about 27.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
767. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 84 mg per
day, and weight of the companion animal is about 28 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
768. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
326
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 85.5 mg
per day, and weight of the companion animal is about 28.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
769. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 87 mg per
day, and weight of the companion animal is about 29 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
770. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 88.5 mg
per day, and weight of the companion animal is about 29.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
771. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
327
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 90 mg per
day, and weight of the companion animal is about 30 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
772. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 91.5 mg
per day, and weight of the companion animal is about 30.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
773. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 93 mg per
day, and weight of the companion animal is about 31 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
328
Date Recue/Date Received 2021-07-07
774. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 94.5 mg
per day, and weight of the companion animal is about 31.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
775. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 96 mg per
day, and weight of the companion animal is about 32 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
776. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 97.5 mg
per day, and weight of the companion animal is about 32.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
329
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
777. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 99 mg per
day, and weight of the companion animal is about 33 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
778. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 100.5 mg
per day, and weight of the companion animal is about 33.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
779. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 102 mg
per day, and weight of the companion animal is about 34 kgi
330
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
780. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 103.5 mg
per day, and weight of the companion animal is about 34.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
781. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 105 mg
per day, and weight of the companion animal is about 35 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
782. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
331
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 106.5 mg
per day, and weight of the companion animal is about 35.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
783. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 108 mg
per day, and weight of the companion animal is about 36 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
784. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 109.5 mg
per day, and weight of the companion animal is about 36.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
785. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
332
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 111 mg
per day, and weight of the companion animal is about 37 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
786. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 112.5 mg
per day, and weight of the companion animal is about 37.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
787. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 114 mg
per day, and weight of the companion animal is about 38 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
333
Date Recue/Date Received 2021-07-07
788. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 115.5 mg
per day, and weight of the companion animal is about 38.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
789. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 117 mg
per day, and weight of the companion animal is about 39 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
790. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 118.5 mg
per day, and weight of the companion animal is about 39.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
334
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
791. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 120 mg
per day, and weight of the companion animal is about 40 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
792. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 121.5 mg
per day, and weight of the companion animal is about 40.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
793. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 123 mg
per day, and weight of the companion animal is about 41 kgi
335
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
794. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 124.5 mg
per day, and weight of the companion animal is about 41.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
795. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 126 mg
per day, and weight of the companion animal is about 42 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
796. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
336
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 127.5 mg
per day, and weight of the companion animal is about 42.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
797. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 129 mg
per day, and weight of the companion animal is about 43 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
798. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 130.5 mg
per day, and weight of the companion animal is about 43.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
799. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
337
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 132 mg
per day, and weight of the companion animal is about 44 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
800. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 133.5 mg
per day, and weight of the companion animal is about 44.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
801. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 135 mg
per day, and weight of the companion animal is about 45 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
338
Date Recue/Date Received 2021-07-07
802. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 136.5 mg
per day, and weight of the companion animal is about 45.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
803. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 138 mg
per day, and weight of the companion animal is about 46 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
804. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 139.5 mg
per day, and weight of the companion animal is about 46.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
339
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weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
805. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 141 mg
per day, and weight of the companion animal is about 47 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
806. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 142.5 mg
per day, and weight of the companion animal is about 47.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
807. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 144 mg
per day, and weight of the companion animal is about 48 kgi
340
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
808. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 145.5 mg
per day, and weight of the companion animal is about 48.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
809. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 147 mg
per day, and weight of the companion animal is about 49 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
810. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
341
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 148.5 mg
per day, and weight of the companion animal is about 49.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
811. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 150 mg
per day, and weight of the companion animal is about 50 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
812. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 3.5 mg per
day, and weight of the companion animal is about 1 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
813. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
342
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 5.25 mg
per day, and weight of the companion animal is about 1.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
814. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 7 mg per
day, and weight of the companion animal is about 2 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
815. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 8.75 mg
per day, and weight of the companion animal is about 2.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
343
Date Recue/Date Received 2021-07-07
816. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 10.5 mg
per day, and weight of the companion animal is about 3 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
817. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 12.25 mg
per day, and weight of the companion animal is about 3.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
818. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 14 mg per
day, and weight of the companion animal is about 4 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
344
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
819. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 15.75 mg
per day, and weight of the companion animal is about 4.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
820. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 17.5 mg
per day, and weight of the companion animal is about 5 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
821. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 19.25 mg
per day, and weight of the companion animal is about 5.5 kgi
345
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
822. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 21 mg per
day, and weight of the companion animal is about 6 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
823. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 22.75 mg
per day, and weight of the companion animal is about 6.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
824. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
346
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 24.5 mg
per day, and weight of the companion animal is about 7 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
825. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 26.25 mg
per day, and weight of the companion animal is about 7.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
826. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 28 mg per
day, and weight of the companion animal is about 8 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
827. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
347
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 29.75 mg
per day, and weight of the companion animal is about 8.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
828. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 31.5 mg
per day, and weight of the companion animal is about 9 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
829. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 33.25 mg
per day, and weight of the companion animal is about 9.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
348
Date Recue/Date Received 2021-07-07
830. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 35 mg per
day, and weight of the companion animal is about 10 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
831. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 36.75 mg
per day, and weight of the companion animal is about 10.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
832. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 38.5 mg
per day, and weight of the companion animal is about 11 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
349
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
833. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 40.25 mg
per day, and weight of the companion animal is about 11.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
834. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 42 mg per
day, and weight of the companion animal is about 12 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
835. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 43.75 mg
per day, and weight of the companion animal is about 12.5 kgi
350
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
836. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 45.5 mg
per day, and weight of the companion animal is about 13 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
837. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 47.25 mg
per day, and weight of the companion animal is about 13.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
838. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
351
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 49 mg per
day, and weight of the companion animal is about 14 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
839. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 50.75 mg
per day, and weight of the companion animal is about 14.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
840. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 52.5 mg
per day, and weight of the companion animal is about 15 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
841. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
352
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 54.25 mg
per day, and weight of the companion animal is about 15.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
842. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 56 mg per
day, and weight of the companion animal is about 16 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
843. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 57.75 mg
per day, and weight of the companion animal is about 16.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
353
Date Recue/Date Received 2021-07-07
844. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 59.5 mg
per day, and weight of the companion animal is about 17 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
845. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 61.25 mg
per day, and weight of the companion animal is about 17.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
846. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 63 mg per
day, and weight of the companion animal is about 18 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
354
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
847. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 64.75 mg
per day, and weight of the companion animal is about 18.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
848. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 66.5 mg
per day, and weight of the companion animal is about 19 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
849. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 68.25 mg
per day, and weight of the companion animal is about 19.5 kgi
355
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
850. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 70 mg per
day, and weight of the companion animal is about 20 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
851. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 71.75 mg
per day, and weight of the companion animal is about 20.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
852. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
356
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 73.5 mg
per day, and weight of the companion animal is about 21 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
853. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 75.25 mg
per day, and weight of the companion animal is about 21.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
854. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 77 mg per
day, and weight of the companion animal is about 22 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
855. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
357
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 78.75 mg
per day, and weight of the companion animal is about 22.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
856. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 80.5 mg
per day, and weight of the companion animal is about 23 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
857. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 82.25 mg
per day, and weight of the companion animal is about 23.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
358
Date Recue/Date Received 2021-07-07
858. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 84 mg per
day, and weight of the companion animal is about 24 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
859. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 85.75 mg
per day, and weight of the companion animal is about 24.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
860. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 87.5 mg
per day, and weight of the companion animal is about 25 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
359
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
861. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 89.25 mg
per day, and weight of the companion animal is about 25.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
862. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 91 mg per
day, and weight of the companion animal is about 26 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
863. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 92.75 mg
per day, and weight of the companion animal is about 26.5 kgi
360
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
864. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 94.5 mg
per day, and weight of the companion animal is about 27 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
865. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 96.25 mg
per day, and weight of the companion animal is about 27.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
866. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
361
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 98 mg per
day, and weight of the companion animal is about 28 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
867. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 99.75 mg
per day, and weight of the companion animal is about 28.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
868. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 101.5 mg
per day, and weight of the companion animal is about 29 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
869. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
362
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 103.25 mg
per day, and weight of the companion animal is about 29.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
870. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 105 mg
per day, and weight of the companion animal is about 30 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
871. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 106.75 mg
per day, and weight of the companion animal is about 30.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
363
Date Recue/Date Received 2021-07-07
872. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 108.5 mg
per day, and weight of the companion animal is about 31 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
873. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 110.25 mg
per day, and weight of the companion animal is about 31.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
874. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 112 mg
per day, and weight of the companion animal is about 32 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
364
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
875. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 113.75 mg
per day, and weight of the companion animal is about 32.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
876. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 115.5 mg
per day, and weight of the companion animal is about 33 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
877. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 117.25 mg
per day, and weight of the companion animal is about 33.5 kgi
365
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
878. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 119 mg
per day, and weight of the companion animal is about 34 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
879. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 120.75 mg
per day, and weight of the companion animal is about 34.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
880. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
366
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 122.5 mg
per day, and weight of the companion animal is about 35 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
881. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 124.25 mg
per day, and weight of the companion animal is about 35.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
882. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 126 mg
per day, and weight of the companion animal is about 36 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
883. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
367
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 127.75 mg
per day, and weight of the companion animal is about 36.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
884. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 129.5 mg
per day, and weight of the companion animal is about 37 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
885. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 131.25 mg
per day, and weight of the companion animal is about 37.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
368
Date Recue/Date Received 2021-07-07
886. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 133 mg
per day, and weight of the companion animal is about 38 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
887. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 134.75 mg
per day, and weight of the companion animal is about 38.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
888. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 136.5 mg
per day, and weight of the companion animal is about 39 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
369
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
889. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 138.25 mg
per day, and weight of the companion animal is about 39.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
890. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 140 mg
per day, and weight of the companion animal is about 40 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
891. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 141.75 mg
per day, and weight of the companion animal is about 40.5 kgi
370
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
892. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 143.5 mg
per day, and weight of the companion animal is about 41 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
893. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 145.25 mg
per day, and weight of the companion animal is about 41.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
894. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
371
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 147 mg
per day, and weight of the companion animal is about 42 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
895. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 148.75 mg
per day, and weight of the companion animal is about 42.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
896. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 150.5 mg
per day, and weight of the companion animal is about 43 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
897. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
372
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 152.25 mg
per day, and weight of the companion animal is about 43.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
898. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 154 mg
per day, and weight of the companion animal is about 44 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
899. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 155.75 mg
per day, and weight of the companion animal is about 44.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
373
Date Recue/Date Received 2021-07-07
900. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 157.5 mg
per day, and weight of the companion animal is about 45 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
901. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 159.25 mg
per day, and weight of the companion animal is about 45.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
902. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 161 mg
per day, and weight of the companion animal is about 46 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
374
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
903. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 162.75 mg
per day, and weight of the companion animal is about 46.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
904. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 164.5 mg
per day, and weight of the companion animal is about 47 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
905. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 166.25 mg
per day, and weight of the companion animal is about 47.5 kgi
375
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
906. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 168 mg
per day, and weight of the companion animal is about 48 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
907. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 169.75 mg
per day, and weight of the companion animal is about 48.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
908. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
376
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 171.5 mg
per day, and weight of the companion animal is about 49 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
909. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 173.25 mg
per day, and weight of the companion animal is about 49.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
910. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 175 mg
per day, and weight of the companion animal is about 50 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
911. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
377
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 4 mg per
day, and weight of the companion animal is about 1 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
912. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 6 mg per
day, and weight of the companion animal is about 1.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
913. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 8 mg per
day, and weight of the companion animal is about 2 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
378
Date Recue/Date Received 2021-07-07
914. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 10 mg per
day, and weight of the companion animal is about 2.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
915. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 12 mg per
day, and weight of the companion animal is about 3 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
916. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 14 mg per
day, and weight of the companion animal is about 3.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
379
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
917. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 16 mg per
day, and weight of the companion animal is about 4 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
918. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 18 mg per
day, and weight of the companion animal is about 4.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
919. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 20 mg per
day, and weight of the companion animal is about 5 kg:,
380
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
920. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 22 mg per
day, and weight of the companion animal is about 5.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
921. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 24 mg per
day, and weight of the companion animal is about 6 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
922. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
381
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 26 mg per
day, and weight of the companion animal is about 6.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
923. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 28 mg per
day, and weight of the companion animal is about 7 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
924. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 30 mg per
day, and weight of the companion animal is about 7.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
925. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
382
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 32 mg per
day, and weight of the companion animal is about 8 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
926. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 34 mg per
day, and weight of the companion animal is about 8.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
927. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 36 mg per
day, and weight of the companion animal is about 9 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
383
Date Recue/Date Received 2021-07-07
928. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 38 mg per
day, and weight of the companion animal is about 9.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
929. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 40 mg per
day, and weight of the companion animal is about 10 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
930. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 42 mg per
day, and weight of the companion animal is about 10.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
384
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
931. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 44 mg per
day, and weight of the companion animal is about 11 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
932. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 46 mg per
day, and weight of the companion animal is about 11.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
933. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 48 mg per
day, and weight of the companion animal is about 12 kg:,
385
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
934. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 50 mg per
day, and weight of the companion animal is about 12.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
935. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 52 mg per
day, and weight of the companion animal is about 13 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
936. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
386
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 54 mg per
day, and weight of the companion animal is about 13.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
937. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 56 mg per
day, and weight of the companion animal is about 14 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
938. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 58 mg per
day, and weight of the companion animal is about 14.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
939. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
387
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 60 mg per
day, and weight of the companion animal is about 15 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
940. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 62 mg per
day, and weight of the companion animal is about 15.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
941. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 64 mg per
day, and weight of the companion animal is about 16 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
388
Date Recue/Date Received 2021-07-07
942. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 66 mg per
day, and weight of the companion animal is about 16.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
943. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 68 mg per
day, and weight of the companion animal is about 17 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
944. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 70 mg per
day, and weight of the companion animal is about 17.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
389
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
945. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 72 mg per
day, and weight of the companion animal is about 18 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
946. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 74 mg per
day, and weight of the companion animal is about 18.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
947. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 76 mg per
day, and weight of the companion animal is about 19 kg:,
390
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
948. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 78 mg per
day, and weight of the companion animal is about 19.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
949. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 80 mg per
day, and weight of the companion animal is about 20 kg1
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
950. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
391
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 82 mg per
day, and weight of the companion animal is about 20.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
951. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 84 mg per
day, and weight of the companion animal is about 21 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
952. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 86 mg per
day, and weight of the companion animal is about 21.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
953. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
392
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 88 mg per
day, and weight of the companion animal is about 22 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
954. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 90 mg per
day, and weight of the companion animal is about 22.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
955. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 92 mg per
day, and weight of the companion animal is about 23 kg:,
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
393
Date Recue/Date Received 2021-07-07
956. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 94 mg per
day, and weight of the companion animal is about 23.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
957. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 96 mg per
day, and weight of the companion animal is about 24 kg;
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
958. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 98 mg per
day, and weight of the companion animal is about 24.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
394
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
959. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 100 mg
per day, and weight of the companion animal is about 25 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
960. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 102 mg
per day, and weight of the companion animal is about 25.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
961. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 104 mg
per day, and weight of the companion animal is about 26 kgi
395
Date Recue/Date Received 2021-07-07
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
962. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 106 mg
per day, and weight of the companion animal is about 26.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
963. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 108 mg
per day, and weight of the companion animal is about 27 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
964. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
396
Date Recue/Date Received 2021-07-07
wherein the therapeutically effective amount of grapiprant is about 110 mg
per day, and weight of the companion animal is about 27.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
965. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 112 mg
per day, and weight of the companion animal is about 28 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
966. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 114 mg
per day, and weight of the companion animal is about 28.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
967. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
397
Date Recue/Date Received 2021-07-07
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 116 mg
per day, and weight of the companion animal is about 29 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
968. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 118 mg
per day, and weight of the companion animal is about 29.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
969. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 120 mg
per day, and weight of the companion animal is about 30 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
398
Date Recue/Date Received 2021-07-07
970. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 122 mg
per day, and weight of the companion animal is about 30.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
971. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 124 mg
per day, and weight of the companion animal is about 31 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
972. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 126 mg
per day, and weight of the companion animal is about 31.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
399
Date Recue/Date Received 2021-07-07
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
973. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 128 mg
per day, and weight of the companion animal is about 32 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
974. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 130 mg
per day, and weight of the companion animal is about 32.5 kgi
wherein the composition causes no clinically significant adverse
gastrointestinal effects or changes in drug related effects in mortality, body
weight, food consumption, ophthalmology, electrocardiogram, hematology,
coagulation, or gross pathological findings in the companion animal.
975. An oral pharmaceutical composition for treating pain or inflammation
in
a companion animal in need thereof, comprising:
a therapeutically effective amount of grapiprant;
0.1-5% surfactant; and
at least one excipient;
wherein the therapeutically effective amount of grapiprant is about 132 mg
per day, and weight of the companion animal is about 33 kgi
400
Date Recue/Date Received 2021-07-07
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