FILM ANTIMICROBIEN A DESTRUCTION RAPIDE

ANTIMICROBIAL QUICK KILL FILM

Abrégé français

L'invention concerne la prévention de la propagation de bactéries et d'une maladie infectieuse par préparation d'un film polymère présentant des propriétés bactéricides immédiates. Dans la présente invention, l'agent antimicrobien est stocké dans un support qui peut réguler la vitesse de libération de l'agent antimicrobien, d'une heure à plusieurs mois. Il convient d'observer que les propriétés antimicrobiennes du film produit par la présente invention sont personnalisables. Ce produit peut être utilisé dans des établissements de santé sous forme de revêtements intelligents, afin de prévenir la transmission de microbes/d'infections à chaque individu par contact direct et indirect. De plus, il peut être utilisé en tant que bâches intelligentes dans les zones recevant du public et le transport public.

Abrégé anglais

The purpose of the invention is preventing the spread of bacteria and
infectious disease by preparing a polymeric film
with immediate bactericidal properties. In this invention, an antimicrobial
agent is stored in a carrier which can regulate the antimicrobial
agent release rate from an hour to several months. It should be noted that the
antimicrobial properties of the film produced in this
invention are customizable. This product can be used in the health-care
facilities as smart coatings to prevent the transmission of
microbes/ infections to every individual by direct and indirect contact.
Moreover, it can be used as a smart covers in public areas and
public transportation.

Revendications

5
Antimicrobial quick kill film
Claims
1. Antimicrobial quick kill film which is consisted of following components:
a. LLDPE / EVA Polymers
b. PEG
c. Benzalkonium chloride
2. According to claim 1, the percentage of LLDPE / EVA / Oil polymers in
antimicrobial quick kill
film ranges 70%/28%/2%.
3. According to claim 1, PEG has molecular weights 400 and 4000 with the
volume fraction of
50%/50%.
4. According to claim 1, benzalkonium chloride is added with the volume
fraction of 0.13%.
5. According to claim 1, the film has different percentages of LLDPE / EVA /
Oil polymers,
about 90%-10% / 10%-90% / 1% - 30%.
6. According to claim 3, PEG can be used alone or in a combination with a
molecular mass of 300
g /Mole up to 10,000,000g with a composition of 1% - 30%.
7. According to claim 4, benzalkonium chloride has composition of 0.01% -20%.
8. To prepare an antimicrobial quick kill film, PEG and benzalkonium chloride
are first mixed in
a dry blender.
9. According to claim 8, subsequently, EVA and LLDPE are added into the final
blend in the
dry blender, respectively.
10. According to claims 7 and 8, next, the final blend is processed in Twin
screw extruder
11. According to claims 7, 8, 9 and 10, finally, a film blowing machine is
used to provide smart
films at temperatures between 135-140 ° C.
12. According to claim 1, in the present invention, for the preparation of the
antimicrobial films
polymers such as ethylene-based polymers (high-density polyethylene (HDPE),
low density
polyethylene (LDPE), linear low density polyethylene (LLDPE) ), polypropylene
(PP),
polyamide (PA), polystyrene (PS), Polyethylene terephthalate (PET), polyvinyl
chloride (PVC),
Ethylene vinyl acetate (EVA) (8%, 18%, 28%, 38%) and natural polymers such as
starch, poly
lactic acid (PLA), natural rubber (NR) and Acrylonitrile butadiene rubber
(NBR), or a
combination of one or more polymers by percentages 5% to 50% can be used.
13. According to claim 12, all films contain one or more carriers that hold
antimicrobial agents,
polymer's-compatible oils such as polyethylene glycol (PEG) with a molecular
weight varies
from 300 g / mol to 10,000,000 g / mol, Polypropylene glycol (PPG), Dioctyl
phthalate (DOP),
diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), with a composition
of 1% to 30%.
14. According to claim 1, antimicrobial agents such as ethanol, isopropanol,
chlorhexidine,
propyl alcohol, benzalkonium chloride, peracetic acid, hydrogen peroxide,
Didecyldimethylammonium chloride, Polyhexamethylene Biguanide Hydrochloride,
chlorhexidine gluconate, alkyl dimethyl benzyl ammonium chloride, Sodium
hypochlorite,
iodine, 70% alcohol, glutaraldehyde, Sodium iodide and chloramine T, with the
composition of
0.01% to 20% can be used.

Description

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Antimicrobial Quick Kill Film
Technical field:
The technical field of this invention is related to medical, public healthcare
products and health
care facilities.
Technical issue:
Nowadays, given increasing trend of infections, there is an urgent need to
antibacterial agents
and films. For example, about 2 million people in the United States suffer
from illnesses
associated with nosocomial infections, of which around 900,000 people die each
year.
In recent years, common additives such as ceramic nanoparticles, metal
nanoparticles, silver
nanoparticles, iron oxide nanoparticles, zinc oxide nanoparticles, titanium
dioxide, magnesium
oxide, and copper oxide are used to prepare antimicrobial films and coatings.
Antimicrobial
coatings and films available on the market have a killing time over 24 hours.
Therefore, they are
not able to use in infected areas because they cannot kill bacteria and germs
immediately.
Antimicrobial additives such as ethanol, isopropanol, chlorhexidine, propyl
alcohol,
benzalkonium chloride, peracetic acid, hydrogen peroxide,
Didecyldimethylammonium chloride,
Polyhexamethylene Biguanide Hydrochloride, chlorhexidine gluconate, alkyl
dimethyl benzyl
ammonium chloride, Sodium hypochlorite, iodine, 70% alcohol, glutaraldehyde,
Sodium iodide
and chloramine T, or a combination of these additives have immediate effect
(under 24 hours) on
bacteria. Usually these additives are used in gels and sprays and antiseptic
tissues and so far
these additives have not been used to produce antimicrobial films with self-
antiseptics surface.
Prior arts:
= WO 2014/001541 is an invention related to an antimicrobial package
suitable for
containing materials which are susceptible to microbial growth or spoilage. In
particular,
the invention relates to an antimicrobial package for food and drink products
= WO 2006/000032 refers to an antimicrobial polymeric package in which an
antimicrobial
additive has been used. This invention can be used in food packaging. In this
invention,
the polymeric materials are ethylene vinyl acetate (EVA), low-density
polyethylene (PE),
polyethylene glycol oil (PEG) and volatile antimicrobial oils.
Previous inventions dealt with food and fruit packaging, aimed at preventing
entry of essential
nutrients for bacterial growth, which ultimately leads to prolonging life span
of the package
content. It should be noted that market's available films with antimicrobial
properties do not
have the ability to remove bacteria instantaneously and immediately. They are
used only for food
and fruit packaging. Up to this time, an anti-microbial film with the aim of
killing bacteria in a
fraction of second has not been produced.

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Description of the invention:
The purpose of the invention is preventing the spread of bacteria and
infectious disease by
preparing a polymeric film with immediate bactericidal properties. In this
invention, an
antimicrobial agent is stored in a carrier which can regulate the
antimicrobial agent release rate
from an hour to several months. It should be noted that the antimicrobial
properties of the film
produced in this invention are customizable. This product can be used in the
health-care facilities
as smart coatings to prevent the transmission of microbes/ infections to every
individual by direct
and indirect contact. Moreover, it can be used as a smart covers in public
areas and public
transportation.
In the present invention, polymers such as ethylene-based polymers (high-
density polyethylene
(HDPE) , low density polyethylene (LDPE), linear low density polyethylene
(LLDPE) ),
polypropylene (PP), polyamide (PA), polystyrene (PS), Polyethylene
terephthalate (PET),
polyvinyl chloride (PVC), Ethylene vinyl acetate (EVA) (8%, 18%, 28%, 38%) and
natural
polymers such as starch, poly lactic acid (PLA), natural rubber (NR) and
Acrylonitrile butadiene
rubber (NBR), or a combination of one or more polymers by percentages 5% to
50% can be used
for the preparation of the antimicrobial films.
All films contain one or more carriers that hold antimicrobial agents,
polymer's-compatible oils
such as polyethylene glycol (PEG) with a molecular weight varies from 300 g /
mole to
10,000,000 g! mole, Polypropylene glycol (PPG), Dioctyl phthalate (DOP),
diisodecyl phthalate
(DIDP), diisononyl phthalate (DINP) with a composition of 1% to 30%.
Moreover, antimicrobial agents such as ethanol, isopropanol, chlorhexidine,
propyl alcohol,
benzalkonium chloride, peracetic acid, hydrogen peroxide,
Didecyldimethylammonium chloride,
Polyhexamethylene Biguanide Hydrochloride, chlorhexidine gluconate, alkyl
dimethyl benzyl
ammonium chloride, Sodium hypochlorite, iodine, 70% alcohol, glutaraldehyde,
Sodium iodide
and chloramine T, with the composition of 0.01% to 20% can be used. Based on
the type of the
polymer oil and antimicrobial agents, the effective film performance time
range can be tuned.
In support of this claim, the polymers that were used to prepare the films for
this invention were
LLDPE / EVA/ Oil with the volume fraction of (70%/28%/2%), respectively. The
combination
of PEG 400 and 4000 with the volume fraction of 50%/50% were used as an
antimicrobial
carrier and benzalkonium chloride was used as antimicrobial agent with the
volume fraction of
0.13%.
It should be noted that the films prepared by combining different percentages
of polymers
LLDPE / EVA / Oil ( 90%-60%/10%-40%/ 1%-20%) and PEG as carrier material alone
with a
molecular mass of 300 g /Mole up to 10,000g / mole with a composition of 1% -
30% of PEG or
a combination of them with different molecular weights ranging from 300 g!
mole to 10,000 g!
mole with a composition of 1% -30% and benzalkonium chloride as an
antimicrobial agent with
a composition of 0.01% 20% is within the scope of this invention.

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After preparing different specimens, antimicrobial activity of the films was
investigated. E.coli
bacteria with the concentration of 106 x 1.5 CFU / ml was prepared. 100 pl of
fluid was
contacted for 24 hours before inoculation with the sample. After culturing the
medium for 8
hours, according to the optical density method, each sample series was
evaluated using three
biological replications at 600 nm wavelength. The results of microbial tests
taken at different
time intervals from films prepared with different composition percentages
showed that 98.9% of
bacteria were killed.
In addition, Performance repeatability of the films was tested by the
Luminometer device with
the general swab. The dirty object was rubbed several times with specific
intervals on the
armchair covered with the antimicrobial film and on the armchair without the
antimicrobial film.
The results show that the covered-armchair is in the sterile range after
rubbing the dirty object.
To prepare the samples, PEG and benzalkonium chloride were first mixed
together in a dry
blender, then EVA was added and then LLDPE was added to the final blend in a
dry blender.
Finally, the final blend was processed in a twin screw extruder. Finally, a
film blowing machine
was used to make smart films. The temperature range was applied to all the
machines has been
set between 135-140 C.
Advantages of the invention:
= The absence of antimicrobial film with instantaneous killing action.
= Reduce the necessary time to wash or clean the surface
= Cost-effectiveness
= There is no need to clean surfaces with detergents over time
= Production of various antimicrobial smart films with complex shapes and
dimensions
= Production of antimicrobial smart films with the potential of tuning and
adjusting the
release of effective antimicrobial agents
A practical approach to invention implementation:
The film produced in this invention can be used in disposable and multi-use
applications in
various industries and locations. Generally, the user should choose the
appropriate film based on
the sensitivity of the desired location. Generally, based on the type of film,
the user must, at the
beginning of each shift (or based on the time period written on the film) ,
according to different
places, the consumer should covers the desired location and then depending on
the determined
time collects the film covers and replaced them with the new covers.
(according to the place the
films are consumed, they can be in the different forms such as rolled-films,
pre-shaped films,
shrink films and etc.)
Briefly, some of the applications of this film are as follow.

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For example, in the hospital, the film can be stretched over on the seating
chairs in waiting
rooms, beds, hospitals equipment that are frequently touched by patientsõ
nurses, doctors,
medical specialists and health care facilities, etc. It can be used in public
transportation, for
example, subway and bus handles and escalator handles. In educational centers,
for example, it
can be wrapped up in a kindergarten on a children's playground, on children's
play toys such as
chute, swings and so on.
Explicit industrial application of invention
= The medical and dental industry
= Medical and dental equipment industry
= Healthcare equipment industry
= Public Transportation Equipment Industry
= The retail industry
= Educational Centers
= Public area